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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV4</accession>
    <name>F9UKV4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bla1</name>
        <name evidence="3" type="ordered locus">lp_0469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101017.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888483.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0469"/>
    <dbReference type="EnsemblBacteria" id="CCC77969">
        <property type="protein sequence ID" value="CCC77969"/>
        <property type="gene ID" value="lp_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0469"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.386"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_9_4_9"/>
    <dbReference type="OMA" id="NWTSTRD"/>
    <dbReference type="PhylomeDB" id="F9UKV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-390-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388961" evidence="1">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="110"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="31559" checksum="0A410155C6508CC4" modified="2011-10-19" version="1">MQTKKWIRGLVCGLALLGGWSLALPVHATSVKSEQTAVKKIAQRDLKSLGGRWSVKVTRLGRRKLTVQTGNQRMTRQRSASTIKVYVMLTIYRRVQQRKLRLTQQDQNDLKLMIHNSDNSAANRLIKRAGGFRGVNAAIKHYRFKQTVLQRYMLDTNALRWGRDNYTSVADLTRFLTLTYQHKLLGKTYDKKMLTLLKGCRNHSKLPYLVKHVTVYNKTGEYPDKGVQNDAAIFKTKQGTYSIVVMAQNGKQYQQYQGMNRLGRDVVTYLNQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ0</accession>
    <name>F9UKZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888519.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0513"/>
    <dbReference type="EnsemblBacteria" id="CCC78005">
        <property type="protein sequence ID" value="CCC78005"/>
        <property type="gene ID" value="lp_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0513"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.422"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044180_1_0_9"/>
    <dbReference type="OMA" id="GPFVTIM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-426-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040628">
        <property type="entry name" value="BaeRF_family6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18848">
        <property type="entry name" value="baeRF_family6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="378" mass="42505" checksum="0A1426E8F3FB2FE5" modified="2011-10-19" version="1">METMVKNDLNQLMQQREDGPYIAIYLNTAVVLNDLNRRRLQFKQLVNEAETQMAHHFPKTEFAPYATQLEQLINDNAFWLQHTGPQTGIITNSRDLHIFDLQYPTDNHVSVNSMPAIRPVLADRQHQFDFDLLALNEDSMALYAQRDGSFVELDLPAEAPRTLTEALGTEKRGGDLNFNASPVHGANYHGHNAKAEERDIDQRNYYQQVAQYVQAHSQKTRRPLILMGLPHNQAVFRAVNKNPYLSQHLMINKSPKNLTVGAMQTATEPVQTMWHTQLADILLERYDQAKSRQLALADPFDMIKPALSGRIDTLIVAADANVAGSLPAADVQLNDPIAAPDNLIDDLVDVVIAMNGQIRIIPADRMPVETAALAIMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL26</accession>
    <name>F9UL26_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640889.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888555.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0554"/>
    <dbReference type="EnsemblBacteria" id="CCC78041">
        <property type="protein sequence ID" value="CCC78041"/>
        <property type="gene ID" value="lp_0554"/>
    </dbReference>
    <dbReference type="GeneID" id="57024336"/>
    <dbReference type="GeneID" id="66448608"/>
    <dbReference type="KEGG" id="lpl:lp_0554"/>
    <dbReference type="HOGENOM" id="CLU_1720032_0_0_9"/>
    <dbReference type="OMA" id="KKRANHA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-471-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="18170" checksum="74FC3B3066B02A42" modified="2011-10-19" version="1">MTAITIIMSRSYKSTPIFKAHMGYGKKRANRAVRNRMNRGEFDVLPANSHAWYKRCYEQYDVVDYCSRETYSQVQLELETMRLEITRNGGIIRRIPQHLVVTYTFDPVISDIVHMQRTEELIPAQDVQMFVGTFEQWCRERRNCWAKAYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL40</accession>
    <name>F9UL40_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription accessory protein, contains S1 RNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tex</name>
        <name evidence="2" type="ordered locus">lp_0569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="KEGG" id="lpl:lp_0569"/>
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        <property type="entry name" value="RuvA_2-like"/>
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        <property type="entry name" value="Tex-like_dom_sf"/>
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        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="723" mass="80069" checksum="29E4664A33B3474E" modified="2011-10-19" version="1">MDNQILTLVNQTLTKFKPQQIKAVLGLMDEGNTVPFIARYRKERTGNLDEVEIREIKDNYDRLASLESRKADVMKLIAEQDHLTPALKQAIEKADKLQDVEDLYLPYKQKRRTKATIAKDAGLEPLAAWLLRFPASGIQEHAAQFVNEAQDITDANTALAGAHEILAEAFGDNAGLRNWVRNYTRDRGLLVAKVKPKGKAADEQGVYQQYYDFNSPIKQMVPYRVLAINRGEAEKVLKVSIDVDRAGIDRYCHFRFIGQHHGPAIELVEAAYQDAYKRFIGPAIERELRNELSAAANEQAIKVFGDNLYHLLMQAPLKGRVVLGFDPAYRTGCKLAVMDANGKFLDKLVIYPHKPAPTAKREAAAGEFKAFLEKYHVEMIAIGNGTASRESEEFVAQVLKTMTRPVYYVIVNEAGASVYSASAKARAEFPELHVEQRSAISIGRRLQDPLAELIKIDPKSVGVGQYQHDVPQKELTTQLDTVIETAVNQVGVNLNTASSELLTHISGLSSTIAQNVITYRDENGEFTSRPQLKKVPRLGPKAYEQAVGFLRIIDGKNVFDNTDIHPESYPAAKALLAAAGLKTTDVGTTKAQQLNQLDLAQLATSTGVGELTLKDIISSLQKPGRDVRDTMPAPLLRQDVLKMSDLKPGMQLQGTVRNVVDFGAFVDIGVKQDGLVHVSKLTDKFLKDPRQAVAVGDIVTVWVEEVDEQRQRIALTMIAPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL53</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0583</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888582.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0583"/>
    <dbReference type="EnsemblBacteria" id="CCC78068">
        <property type="protein sequence ID" value="CCC78068"/>
        <property type="gene ID" value="lp_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0583"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.486"/>
    <dbReference type="eggNOG" id="COG4687">
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    <dbReference type="HOGENOM" id="CLU_132588_0_0_9"/>
    <dbReference type="OMA" id="IASVMFK"/>
    <dbReference type="PhylomeDB" id="F9UL53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-499-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF956"/>
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    <dbReference type="Pfam" id="PF06115">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021265">
        <property type="entry name" value="DUF956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <dbReference type="EMBL" id="CCC78068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="14845" checksum="69A33303C0EBB72F" modified="2011-10-19" version="1">MVESLNTKVELVIKGNSHLGLTDYGQIMVGDKGFEFYDERNVRNYIQIPWAEVDSVVVSIMFKGRWIPRYALKTKKNGMYAFSSKNPKRVLRAIRKHVDPDKIVRSLTFFDVLKRAFKGKNRDNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB1</accession>
    <name>F9ULB1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose 5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araD</name>
        <name evidence="2" type="ordered locus">lp_3555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891032.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3555"/>
    <dbReference type="EnsemblBacteria" id="CCC80518">
        <property type="protein sequence ID" value="CCC80518"/>
        <property type="gene ID" value="lp_3555"/>
    </dbReference>
    <dbReference type="GeneID" id="57026754"/>
    <dbReference type="KEGG" id="lpl:lp_3555"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2965"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_9"/>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="PhylomeDB" id="F9ULB1"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="26471" checksum="18E22D818E211CDD" modified="2011-10-19" version="1">MLEALKQEVYEANMQLPKLGLVTFTWGNVSGIDREKGLFVIKPSGVDYGELKPSDLVVVNLQGEVVEGKLNPSSDTPTHTVLYNAFPNIGGIVHTHSPWAVAYAAAQMDVPAMNTTHADTFYGDVPAADALTKEEIEADYEGNTGKTIVKTFQERGLDYEAVPASLVSQHGPFAWGPTPAKAVYNAKVLEVVAEEDYHTAQLTRASSELPQYLLDKHYLRKHGASAYYGQNNAHSKDHAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC7</accession>
    <name>F9ULC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80534">
        <property type="protein sequence ID" value="CCC80534"/>
        <property type="gene ID" value="lp_3572"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3572"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2980"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_0_9"/>
    <dbReference type="OMA" id="IHHFWTF"/>
    <dbReference type="PhylomeDB" id="F9ULC7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3022-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="44453" checksum="49C05D145415D909" modified="2011-10-19" version="1">MSDLDQTNNYRYVIVGGGMVAGYAIKGIRQEDPEGAILVISQEADVPYERPALSKKLWLDDEFTEENIRIGAENYPNVTFKFKTTVTAINRQDKVITLTDSEQIKYEQLLLATGGEPRQIQGPADPHVLVFRQWSDYRKLRKFSGPNKRVVIIGGGYVGTELASSLTQNGTKVTMIFPEKALGEGKFPESIRAEYEATFKRNGVTLMSGQFVQSYQRQGDHLTLLTKDGTAIAADTIIVGLGVTPRISLAEDSSLDLADGGVKVDEYLNTSDPAIWSAGDIASYPDHILGRQRIEHVDHARLSGELVGRNMAGAHMSYQHTPYFYSMIFDISWQAIGNIDPKLQLIFDRRTHGLLVYFIDADKLVGVLVWNVKVNLDDVRALLANAPATDDLVGSIREQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ5</accession>
    <name>F9ULJ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3647"/>
    <dbReference type="EnsemblBacteria" id="CCC80602">
        <property type="protein sequence ID" value="CCC80602"/>
        <property type="gene ID" value="lp_3647"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3647"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3046"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="ERANASC"/>
    <dbReference type="PhylomeDB" id="F9ULJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3089-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="582" mass="65973" checksum="481A0A83515A392E" modified="2011-10-19" version="1">MNPYQWVWQYARHSRWQITLASLLIIVNALGVVAVPLLGGIIVDVVINQRHLNLLLPLLAGMVGITLIRTVMRYCYIILWERVGQNSLYDIRHDLFTKLQSLDYPFFNSVTNGDIMARLTGDTDAIRHFLCWVTYNTAECVLWFLTAVIVMGWLNWQLMLALIILTPIIAWLTTRMSTEAHTVFFDIRQSFAHLNAMVEENISGNRIVRAFAREDYEIEKFQQLNHDYKEKNMASAAVSRRYLPTLDFLASLLSVIVLLLGSILVINHQMSLGQLVSFNGFLWMLNQPMRMSGWLINDIQRFSAATIKIRSMLNTQPTIITTKSQQVVPIRGAVQFQHVDFAFPDTPQVNALLDINFTVEPGQTLGILGETGSGKTTLMNLTARFYDPTNGRILIDGRDIQQWSAQDLRNQITIVTQDLFLFSDTITDNINYGNHDASIPFIREMAAIADANNFIDQMPDGYDTVVGERGVGLSGGQKQRISLTRALVKDPRILILDDTTSALDMETEATIQQRLKTITKNKTVFIIASRISSLRHADHIIVLRHGEIIEQGNHESLLAQNGYYAETYRRQLGLIKDAKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULM6</accession>
    <name>F9ULM6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102291.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3684"/>
    <dbReference type="EnsemblBacteria" id="CCC80633">
        <property type="protein sequence ID" value="CCC80633"/>
        <property type="gene ID" value="lp_3684"/>
    </dbReference>
    <dbReference type="GeneID" id="57026859"/>
    <dbReference type="KEGG" id="lpl:lp_3684"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3077"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_9"/>
    <dbReference type="OMA" id="HCIDNGV"/>
    <dbReference type="PhylomeDB" id="F9ULM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3120-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="56"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="417" mass="45330" checksum="991C4057B1F00CBD" modified="2011-10-19" version="1">MTKTNYINASIYSSEKQTFIDNQFMTVDDATGKIIAVGTGTPDTIAEQTTDMQGKYVMPGIMNAHTHITSIPTYWWHDGQEDRHPESREYNTMYAIHNMQDMVNHGVTYIRNVGAQYDIDVAISKMQREGKIAGPRVMTSGQAFSITGGHGADGGHEVDGVDAVVQGVRQALKMGVDNIKMMVTGGVLRNGETPDDIQFNFEEVQAAVAEAHHKGKTVAAHAQGNAGVKEAVQAGVDTVEHAFDIDDETIEMMRQHGTVIVPTMNAMYAIYKYGEKTVPAWAREKVIVNIKKHFASITKAAAAGIPIAMGTDAGTPYNGFEDESAYEMQLYVDKAGMTPAQAIDTATINCARAMHVADEYGTISAGKFADFIAMTANPIEDIRVIQQDKDVFQHGIQVHQAAKTAGVDEQVPVRQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN7</accession>
    <name>F9ULN7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888640.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0648"/>
    <dbReference type="EnsemblBacteria" id="CCC78126">
        <property type="protein sequence ID" value="CCC78126"/>
        <property type="gene ID" value="lp_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0648"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.542"/>
    <dbReference type="HOGENOM" id="CLU_2649949_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-559-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="8882" checksum="69BA27A55E4DFC85" modified="2011-10-19" version="1">MTSLSMVLGKEAVVAYMVVLTFQGEITKNYPKIYKRYGDAFKRCEHLNHVIKSDDYRWKLMCAKGWYDVDPNDKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN9</accession>
    <name>F9ULN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888642.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0650"/>
    <dbReference type="EnsemblBacteria" id="CCC78128">
        <property type="protein sequence ID" value="CCC78128"/>
        <property type="gene ID" value="lp_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0650"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.544"/>
    <dbReference type="HOGENOM" id="CLU_2012353_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-561-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="13920" checksum="DA289725CFCF9096" modified="2011-10-19" version="1">MMKIVGKLYCIDGNVHSPRDQTLYVVGTNEVDKEQVREACIAYIDDYFGKEYFEKERGTSLKDLVESADLSISYERHIPINEASFDYDIWGSGMYTVGNASGRGARKVWVLSFNDDPFGTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ3</accession>
    <name>F9ULQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 42, major capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101115.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0665"/>
    <dbReference type="DNASU" id="1062012"/>
    <dbReference type="EnsemblBacteria" id="CCC78142">
        <property type="protein sequence ID" value="CCC78142"/>
        <property type="gene ID" value="lp_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0665"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.557"/>
    <dbReference type="eggNOG" id="ENOG502Z97E">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066432_0_0_9"/>
    <dbReference type="OMA" id="PENWGAY"/>
    <dbReference type="PhylomeDB" id="F9ULQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-576-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045404">
        <property type="entry name" value="Gp13-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20036">
        <property type="entry name" value="Gp13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="356" mass="38732" checksum="0D3711A1CE378DE3" modified="2011-10-19" version="1">MVNGNITQLSDMQIPENWGAYLAEKSTQNNAFFTSGVVQNVPQIAALLGAGKVANMPLFKPLADDDPQVPDDTTDLLVNKITTDLAQARKLGFDQAWSATDLSAELSGADPLSAIGDQVSDYWSHVYEKLLLQTLTGVFSSTSMKGVNQLDTTTDKTDTTFSLKNFNKARFLLGDRYKDLAIVAVHSDILRQLQDANLVDAKNNSTFVLNGNSNVPTAIQTPDAGDKIKGVQIVVDDSLPVDNGKYTSYLFAQGAVGYSELPVTNAVETNRDPLKNHGIDYLVNRRRFVFAPQGLSWNESNFVTKNPGKTYPSMTDLADGTNWSKVYDHKLIPMAQFVTSADAIVPSTTADPQTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS5</accession>
    <name>F9ULS5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA entry nuclease</fullName>
            <ecNumber evidence="3">3.1.30.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0688</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.30.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101137.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888678.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0688"/>
    <dbReference type="EnsemblBacteria" id="CCC78164">
        <property type="protein sequence ID" value="CCC78164"/>
        <property type="gene ID" value="lp_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0688"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.577"/>
    <dbReference type="eggNOG" id="COG2169">
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    <dbReference type="HOGENOM" id="CLU_054350_4_2_9"/>
    <dbReference type="OMA" id="NYYETKI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-598-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
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        <property type="entry name" value="Endonuclea_NS_2"/>
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    <dbReference type="Pfam" id="PF13930">
        <property type="entry name" value="Endonuclea_NS_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="CCC78164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="36236" checksum="BC42E75BC55ADF37" modified="2011-10-19" version="1">MALIGTILLFATLYWFWRLHRRYRGRQWWRHSWPAIIALLVSFSILGTSDESTQPTVKTKTVTKTHLVTANNDKQLTALQAANRASASSLKQAAKKLSSSQQHIDKLKATNKQAGATSTTAPTKVNSDHNPSNTTLASKTYNGQQTITINQNQPAFTAKELSTSQGAWQQYGNLDSLNRVTAANALLNQSLMPKAEREALNVRPTGWHNKRISSGWLYNRSHLIGYQLTGQNNNIKNLMTGTRSLNDPEMTTYENQVAAYLKESPKNYVRYQVTPIFKGNELLARGVQMRGQSVGSNAVSFNVYIFNIQPGMTLNYTDGTSQVSH</sequence>
</entry>
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    <accession>F9ULW5</accession>
    <name>F9ULW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Late competence protein,phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">comFC</name>
        <name evidence="2" type="ordered locus">lp_0736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643951.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888718.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0736"/>
    <dbReference type="EnsemblBacteria" id="CCC78204">
        <property type="protein sequence ID" value="CCC78204"/>
        <property type="gene ID" value="lp_0736"/>
    </dbReference>
    <dbReference type="GeneID" id="57024439"/>
    <dbReference type="KEGG" id="lpl:lp_0736"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.620"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_054549_4_0_9"/>
    <dbReference type="OMA" id="DYFSRYK"/>
    <dbReference type="PhylomeDB" id="F9ULW5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-639-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="224" mass="25410" checksum="CF469C23885D6CA1" modified="2011-10-19" version="1">MLACLLCHNIITTKFTLPWILSWQPVMRPVVCSVCWRQFVRIDRATACSKCGRAQKRPQPCTDCQRWPEIGPFHNEALFEYNDAMHDYFQRYKFQGDYQLRQVFAKIMQQAVVQRCAEICLVVPVTPTTLQTRGFNQVAGWLAAPLAPGLMTQATAKSVPQSKKDRQARLRTPQPFKMAPNTILAGRRVLLVDDIYTTGRTMRHAATLLLENGAKSVTGLTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX4</accession>
    <name>F9ULX4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstD</name>
        <name evidence="11" type="ordered locus">lp_0747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643955.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888727.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0747"/>
    <dbReference type="EnsemblBacteria" id="CCC78213">
        <property type="protein sequence ID" value="CCC78213"/>
        <property type="gene ID" value="lp_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="57024447"/>
    <dbReference type="KEGG" id="lpl:lp_0747"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.628"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_9"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="PhylomeDB" id="F9ULX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-648-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="33277" checksum="F86078B0D9F0B111" modified="2011-10-19" version="1">MDKIRESLLKKSVASKIERRGKAISLVCLALIVGIVFLIFYFVASRGLATFFQNHINLWQFLSGTQWNPGTVGTNGQPAVGALPMIVGSFLITILSALIATPFAIGTAVFMTEISPRRGAKILRPVTELLVGIPSVVYGFIGLQVVVPFVRNTFGGSGYGILSGTFVLFVMILPTVTSMTADALNSVPRYYREASLALGATRWQTIYKVVLRAAIPGMLTAVVFGMARAFGEALAVQMVIGNATLLPHNLVSPAATLTSILTMGIGNTVMGSLQNNALWSLAMILLLMSLVFNLVIRYIGRKGKLNHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA6</accession>
    <name>F9UMA6_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888859.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0903"/>
    <dbReference type="DNASU" id="1061741"/>
    <dbReference type="EnsemblBacteria" id="CCC78345">
        <property type="protein sequence ID" value="CCC78345"/>
        <property type="gene ID" value="lp_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0903"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.765"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887930_0_0_9"/>
    <dbReference type="OMA" id="HASEAFW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-781-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="211"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="357" mass="40055" checksum="9E35155842679B1C" modified="2011-10-19" version="1">MSTAVQLKYYRSNFLKGMSFLFKTTQKVYPFNDLFEWRDSMQPIQLTAYQSDWQKQATEYQTLLRQQLQANLLKSSHVGSTAMPQLLARPTIDLALLVKDQAAAVATLHARPVAGTTHTYATQLAANDIHVIITTDKQHYQQLLTFRDYLNAHRTDGRKYTAIREKGVRNGQADLAAYLQTKAAFMASINDKAQDWLATKDQHEHHDRTVRAELVNMCLITNPATGDVLVENKIDAQWSGLTFPGGHVDRGESQVTAMKREVLEETGLHVDQLKLVGTVTWVENADGDVSLGTLYTTSHYHGDLLAGSYEGAISWQPLSQLTPDKLAPGVDQILKVFTDAHASEAFWGFDDDQLRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME9</accession>
    <name>F9UME9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641193.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888902.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0954"/>
    <dbReference type="EnsemblBacteria" id="CCC78388">
        <property type="protein sequence ID" value="CCC78388"/>
        <property type="gene ID" value="lp_0954"/>
    </dbReference>
    <dbReference type="GeneID" id="57024629"/>
    <dbReference type="KEGG" id="lpl:lp_0954"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.811"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_11_2_9"/>
    <dbReference type="OMA" id="IYYHITT"/>
    <dbReference type="PhylomeDB" id="F9UME9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-824-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17660" checksum="B3C9FEAFE8CD3CD2" modified="2011-10-19" version="1">MSISTEQTILTQLKTIRTKRASTTGEQKWLQQHITEANLRRLLPDISIVGLHLLSELEAGPQTGIDLATNLGVTRGGVTRAAKRLVTQGLIGSFQQPDDHKKIFYRLTPSGRKLARYHDKMHATRNHQAITLLHEHYSPAELAVIQRFLADLTDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG7</accession>
    <name>F9UMG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase (Short chain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="4">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e92257" last="e92257">
            <title>Esterase LpEst1 from Lactobacillus plantarum: a novel and atypical member of the alphabeta hydrolase superfamily of enzymes.</title>
            <authorList>
                <person name="Alvarez Y."/>
                <person name="Esteban-Torres M."/>
                <person name="Cortes-Cabrera A."/>
                <person name="Gago F."/>
                <person name="Acebron I."/>
                <person name="Benavente R."/>
                <person name="Mardo K."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
                <person name="Mancheno J.M."/>
            </authorList>
            <dbReference type="PubMed" id="24663330"/>
            <dbReference type="DOI" id="10.1371/JOURNAL.PONE.0092257"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2-338</scope>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888920.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="4C87">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.65 A"/>
        <property type="chains" value="A/B/C/D=2-338"/>
    </dbReference>
    <dbReference type="PDB" id="4C88">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.65 A"/>
        <property type="chains" value="A/B/C/D=2-338"/>
    </dbReference>
    <dbReference type="PDB" id="4C89">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B/C/D=2-338"/>
    </dbReference>
    <dbReference type="PDBsum" id="4C87"/>
    <dbReference type="PDBsum" id="4C88"/>
    <dbReference type="PDBsum" id="4C89"/>
    <dbReference type="SMR" id="F9UMG7"/>
    <dbReference type="STRING" id="220668.lp_0973"/>
    <dbReference type="EnsemblBacteria" id="CCC78406">
        <property type="protein sequence ID" value="CCC78406"/>
        <property type="gene ID" value="lp_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0973"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.829"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-842-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="102"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4C87"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4C88"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4C89"/>
        </source>
    </evidence>
    <sequence length="338" mass="36827" checksum="C825587EB023161F" modified="2011-10-19" version="1">MMPTINSIQTTVNGVVKIVKPFNNDIAGEQFDPHVLQTLTAFKQPAILENDLAALRSGSLTPAIADPVGDAVTVQSRNITALNRTVSVEWLTPQNVINHTVLVYFHGGAFYGGVPGNNTVLLKLVAAKSHCEILNVDYSLAPEAPAPAGILDGLAIFQYLEQRDAETMITVAGDSAGANVIMAATNLNQQLGSNRINQQLLLYPVTAPNADHAGPLWDLAAFPIIDSQRAILTNYHDLFRQLDSIMTDYYVPENFDSHSPLISPLHQENFTMTPPTTIMVGEFDPFRPQAWAYAQRLAAADTATTFIQYQGLNHAFAPLVDQYWQSQDVAQVMAAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMN4</accession>
    <name>F9UMN4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heptaprenyl diphosphate synthase component II</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hepB1</name>
        <name evidence="3" type="ordered locus">lp_1066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1066"/>
    <dbReference type="EnsemblBacteria" id="CCC78473">
        <property type="protein sequence ID" value="CCC78473"/>
        <property type="gene ID" value="lp_1066"/>
    </dbReference>
    <dbReference type="GeneID" id="57024719"/>
    <dbReference type="KEGG" id="lpl:lp_1066"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.900"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_9"/>
    <dbReference type="OMA" id="NIVAVMS"/>
    <dbReference type="PhylomeDB" id="F9UMN4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-916-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="330" mass="37124" checksum="B287C2547390F7B7" modified="2011-10-19" version="1">MQSATQLHPIWRDYPALQPELQQVMQLMTANINIQDADINDAILEMIHGGGKLLRPAYCLLFSQFTTTDRQRMVALAASLETLHTATLIHDDIVDDAALRRHHVTIQERFGKDTAVYAGDYLFVVVFKILAHYSSSFKSIQMNSENMEKILVGEVQQKDRHYHLDITMAEYLQQIQGKTAELFALSCFLGAYESGQSSHFAQRARKAGLAIGMAFQILDDILDYQEVSQETGKPILEDVAEGVYTSPLIFALQTEAKHDLLPLMRLQGAISDTQRQEVQRLVINAGGVVQAQELATKYTQDALAIMRKLPDQPAKTDLISLTKRLLDRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ3</accession>
    <name>F9UMQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tartrate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ttdP</name>
        <name evidence="7" type="ordered locus">lp_1087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1087"/>
    <dbReference type="EnsemblBacteria" id="CCC78492">
        <property type="protein sequence ID" value="CCC78492"/>
        <property type="gene ID" value="lp_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1087"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.921"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_7_3_9"/>
    <dbReference type="OMA" id="AMAHISA"/>
    <dbReference type="PhylomeDB" id="F9UMQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-935-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="PTHR42826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="473" mass="50830" checksum="29CBCAA92CDCD35F" modified="2011-10-19" version="1">MTKLQSVNYQQLTWPLIIGLIIWLSAPFRPAGLSLLAWHMLALFVGTIIGCITQPLPIAGVAIIGLTLGVLLGVTSMTDAMAGFGDNTVWMIAMAYFLSRGFVKTGLGRRVALVFVKLFGKKTLGLAYALIGVDLVTSPATPSNTARAGGIVFPIIESLAKAYGSDPQNGTQRKVGSFLIMSAFHGNIATSGLFMTAMAPNLVAVALAQAMQIHITWMDWLLAALLPGLICLISVPAIIYWLYPPEIKDTPNAHAWAANELEQMGAMTLAEKLMGGIFMLALFLWISASLTGLDATLVAFIAVTLLLLTGVLSVDDLLHENGAWNTLVWFSILIFMAGKLNSLGFIPWLSQTMGQALQGISWLWVLAALMLVYFYSHYLFAGATAHVSAMYGAFLGVAISAGAPPMLAALLLGFDGAIFSSTTHYANGPASIMFGSGYITQSEWWRLNLCLGGFYLLVWGVGGTLWMKLLGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ7</accession>
    <name>F9UMQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator tartrate operon, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttdR</name>
        <name evidence="5" type="ordered locus">lp_1092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101255.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1092"/>
    <dbReference type="DNASU" id="1063361"/>
    <dbReference type="EnsemblBacteria" id="CCC78496">
        <property type="protein sequence ID" value="CCC78496"/>
        <property type="gene ID" value="lp_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1092"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.925"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="OMA" id="YHPAYYS"/>
    <dbReference type="PhylomeDB" id="F9UMQ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-939-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="39633" checksum="E612ED52152DE111" modified="2011-10-19" version="1">MIPSQHFQSTPTVQFDLLTYMIGSYHYNWHPQIELLWLLQGTVEVNVDGTRHQLHANDLILINANRGHATFALTPECIALRLHILPDFYTNQGIDLSSGAFLLNSVTTPQHRDYQTIRQILAQLYLGLHQQDWPIFDLNALYFQLTNLLHHDFFDTGITMTYPQPKTQSSLNRVIDYINQAYDRPITLNEAAKISHYSPAYLSRIFKAELGLNFYEYLTRCRLQHAIYDLENPTTRVADLALANGFQEVKSFNLMFKKHFGQTPSSYRQHLSHGQRPEYDQFKQPLTPTQTTIVQKQLNHWAQLTSTDQLSACESCMYKLHFQEYQALKQKIAQLKTLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMU1</accession>
    <name>F9UMU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall hydrolase/muramidase</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acm1</name>
        <name evidence="5" type="ordered locus">lp_1138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 73 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1138"/>
    <dbReference type="EnsemblBacteria" id="CCC78530">
        <property type="protein sequence ID" value="CCC78530"/>
        <property type="gene ID" value="lp_1138"/>
    </dbReference>
    <dbReference type="GeneID" id="57024776"/>
    <dbReference type="KEGG" id="lpl:lp_1138"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.961"/>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013771_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-972-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="4">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="24309" checksum="4C62A88D16BCACCA" modified="2011-10-19" version="1">MMAGKRRKSRRKQRTKTQLFVKKGRLQWVNILLVLAAMVGMVWYIQHNWAVKSRVTATTPTTTHAAFIKKLVPAAQQLDQQYHVLASITLSQAILESDWGQSTNATENNNLFGVKSTSGRLMTTQEYYDGAYHTVKRRFAVYDSWHASLVDHAKKLAYGTTWDSQHYAAVIKATDYQTAAQALQTAGYATDPSYAQKLINIIQKYDLQRYDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMU4</accession>
    <name>F9UMU4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole carboxylase,ATPase subunit</fullName>
            <ecNumber evidence="7">4.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purK2</name>
        <name evidence="7" type="ordered locus">lp_1141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Purine metabolism.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641337.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1141"/>
    <dbReference type="EnsemblBacteria" id="CCC78533">
        <property type="protein sequence ID" value="CCC78533"/>
        <property type="gene ID" value="lp_1141"/>
    </dbReference>
    <dbReference type="GeneID" id="57024779"/>
    <dbReference type="KEGG" id="lpl:lp_1141"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.964"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_9"/>
    <dbReference type="OMA" id="CVLKPIQ"/>
    <dbReference type="PhylomeDB" id="F9UMU4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-975-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043727">
        <property type="term" value="F:5-amino-4-imidazole carboxylate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="389" mass="42832" checksum="A0D5FF723AB82D46" modified="2011-10-19" version="1">MDNSILNPGGTLGIIGSSTNGVGLVIAARNAGINVGVYGDNENTETMELADFRVVGALNDQQQLQNFAERCDMVTYESETIDASVINFLAAHTRVPQGADALEITQDRSLERAFFSQLNLNVAPSATIVSLDDVYQSIGSIGYPSILKPIQKGLGQNRQLVIKTQTDIVKAADLLDWGTYLLESLIPYDKELSVFGAKSGDTTAFFPTVENRYRNHELVASIVPAQIDSAVNDEMLRITKEISDNLSYTGVFEVAFFLTKSGNLYVKRIVPAMHQAGYVFERATNISMAEQHLRAIAGLPLMPVKQLMPVVAAYFTPAQESGIRTQWQIKTNWFFNFYHRTLLQAHRAPVAGHVLVEAPSVKEALEQIEDTSIWQFGQTTPADNEPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ8</accession>
    <name>F9UMZ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP N-acetyl glucosamine 4-epimerase, NAD dependent</fullName>
            <ecNumber evidence="2">5.3.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps2D</name>
        <name evidence="2" type="ordered locus">lp_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.7" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101301.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1200"/>
    <dbReference type="EnsemblBacteria" id="CCC78587">
        <property type="protein sequence ID" value="CCC78587"/>
        <property type="gene ID" value="lp_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1200"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1018"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_9"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="PhylomeDB" id="F9UMZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1030-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050089">
        <property type="term" value="F:mannose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="315" mass="35272" checksum="85BC1CA155A07BDB" modified="2011-10-19" version="1">MKALVTGGAGFIGSHLVDHLVSEGLDVVVVDNLSMGDLHNIKYQDEVTIYVEDVRNEKFMQQLLQEERPDYIYFLAAVASVADSIERPAETHSVNQTAVFNMLEYIRKTNLPIKQFLFTSSAAVYGNLPELPKKEDSRVDPLSPYAIDKYATERFVLAYGELYDLPTVCVRFFNVYGPGQNPSSPYSGVLSILTDCLNNKKPFTLYGDGSQTRDFVYVEDVIQALWLITKSDTEHEVFNIANGNEASLNAIIETYEKVAETSLQIKKAPGREGEVKRSVANIGKLIKLGYTTKWSLEAGLSKYWEGAQQREASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN14</accession>
    <name>F9UN14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glf2</name>
        <name evidence="5" type="ordered locus">lp_1219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1219"/>
    <dbReference type="EnsemblBacteria" id="CCC78603">
        <property type="protein sequence ID" value="CCC78603"/>
        <property type="gene ID" value="lp_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1219"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1033"/>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_9"/>
    <dbReference type="OMA" id="FRVSQYG"/>
    <dbReference type="PhylomeDB" id="F9UN14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1045-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="151"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="377" mass="43234" checksum="C787CF9653332230" modified="2011-10-19" version="1">MNEQYDYLVVGAGLFGAVFAHEAALRGKRVKVIEKRDHIAGNIYTKEVAGIQVHQYGAHIFHTSDREIWDYVNQFAEFNRYTNSPVANYKGHMYNLPFNMNTFSELWGIRTPAEAAAKIAEQRAAANLGDHQPRNLEEQAIALIGTDIYKKLIKGYTEKQWGQKATDLPAFIIRRLPVRYTYDNNYFNDTYQGIPIGGYTQIVEKMLAHPEITVETNTDFFAHKAEYLAQYPKVVFTGMIDQFFDYQLGELAYRSLRFETETVPVDNYQGNAVVNYTDAETPYTRVIEHKHFEFGKGDAGQTVITREFPANWQRGDEPYYPVNNQTNNTLYKQYAKLAAAEPQVIFGGRLGQYRYYDMHQVIHAALVTVASEFATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN32</accession>
    <name>F9UN32_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101329.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889135.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1239"/>
    <dbReference type="EnsemblBacteria" id="CCC78621">
        <property type="protein sequence ID" value="CCC78621"/>
        <property type="gene ID" value="lp_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1239"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1051"/>
    <dbReference type="eggNOG" id="ENOG50309S9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164690_0_0_9"/>
    <dbReference type="OMA" id="MADTDHE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1062-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="28738" checksum="5E4394F9F5D69F29" modified="2011-10-19" version="1">MLERNTDFEGDLPSMNQNIDVPHHVNTFWQCHAGTWDTRQPQRLLVIAQRSELATIDVLETLFLLDIKHLTCVENTLIFDRQRGLIKTKLTTRQIMMNYAGRLGLSGTQLIKQLAGELGLSKHKLPVIHGDAILMPLSTAKRGTTSWYNRHYLNHIEAQGFMTALVYDGQITIQVDMSERVVTRQLVKAGQLQAALQEHHRRRLVPDQSVPSMADTDHEMMQSYTDQVLKHFGILALPGEISCLTRRFFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN41</accession>
    <name>F9UN41_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gntP</name>
        <name evidence="2" type="ordered locus">lp_1249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889144.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1249"/>
    <dbReference type="DNASU" id="1062978"/>
    <dbReference type="EnsemblBacteria" id="CCC78630">
        <property type="protein sequence ID" value="CCC78630"/>
        <property type="gene ID" value="lp_1249"/>
    </dbReference>
    <dbReference type="GeneID" id="57024870"/>
    <dbReference type="KEGG" id="lpl:lp_1249"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1060"/>
    <dbReference type="eggNOG" id="COG2610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027949_0_0_9"/>
    <dbReference type="OMA" id="LMRIGIP"/>
    <dbReference type="PhylomeDB" id="F9UN41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1071-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="451" mass="47177" checksum="D46325CE12D66D84" modified="2011-10-19" version="1">MPFVVLTLGILLLLLLIIKFKLNTYIALIVTAVVVGIGLGMPLTKIATSIQNGIGSQLGELALVFGFGAMLGRLVADAGGAYTISTTLLDIFGRKRLQIAIVVASFIIGIALFFEVGIVLLIPIVFAIAIEAQVPVLYLGIPMGAALSVTHGFLPPHPAPTAIATTLNANVGHVLLFGIIIAIPTVYIAGPLFSRWAQKMVPDAFTGKPHLPLSSNKRQFKVSEAPGFGLSVLTALFPVILMTITTVYELVVDHGVTPKNPSTLDQIIRLIGAPGIAMLISLLFALWSMGIHQHKTNKAITATIEDATKSIAMLLLIIGGGGAFKQILIDGGVGKAVAQLFSGSSISPLILGWLVAVILRVSLGSATVAALTAAGLVAPLMTQAGIDPALMVIAIGSGSVAASHVNDAGFWMFREYFDLTVKQTLLTWTMLETIIAVCGLGGVLALNAIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN54</accession>
    <name>F9UN54_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppD</name>
        <name evidence="7" type="ordered locus">lp_1264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889157.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1264"/>
    <dbReference type="EnsemblBacteria" id="CCC78643">
        <property type="protein sequence ID" value="CCC78643"/>
        <property type="gene ID" value="lp_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="57024883"/>
    <dbReference type="GeneID" id="66449140"/>
    <dbReference type="KEGG" id="lpl:lp_1264"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1074"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="PhylomeDB" id="F9UN54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1084-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="359" mass="39728" checksum="D8F5720B19B9ADD6" modified="2011-10-19" version="1">MEKPENVIEVRNLEINFHTYAGEVKAIRDVSFDLRKGETLAIVGESGSGKSVTTRSLMGLLAPNAEIKRGSIMFHGEDIIKKSEKDMQHIRGKDIAMIFQDPMTSLDPTMRIGMQIAEPLMKHKGLKKKEAIAQALEMLKLVGITNPEGRINDYPYQFSGGMRQRIVIAIALVCYPEVLIADEPTTALDVTIQAQILDLMKDLQNRIDTSIIFITHDLGVVAGMADRVAVMYAGKIVEYGTVDEIFFNPQHPYTWGLLNSMPTLDTESGSLSAIPGTPPDLLEPPVGDAFAARSDYAMKIDTEKEPPFFKVSDTHYAATWLLHPDAPKVTPPAEIVRRQQKFAAMQKPQAPISNPVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN64</accession>
    <name>F9UN64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dacA2</name>
        <name evidence="11" type="ordered locus">lp_1278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889167.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1278"/>
    <dbReference type="EnsemblBacteria" id="CCC78653">
        <property type="protein sequence ID" value="CCC78653"/>
        <property type="gene ID" value="lp_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1278"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1085"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_8_2_9"/>
    <dbReference type="OMA" id="RNMMSAS"/>
    <dbReference type="PhylomeDB" id="F9UN64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1095-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388049" evidence="9">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="412" mass="45206" checksum="4E2F53F5BDDBA977" modified="2011-10-19" version="1">MLKLIKQRLVWGLVLTATVSGVLGCNVAAHATSSKADEVKAAYVMDAKSGQVVYAQNADQKLPIASLSKLMTLYLVERAIEHGQIKWTDAVPIRKNVRKMATSATLSVMPMPAKETFTVRELFAATLVGSSNSGAIALGEYVAGSNDKFIKLMNQQAAKWHLDASFISASGLDNTDLKNYDLKIKGTSDQDQNLVSARAVTTIAQHLIDAYPDVIQVANQRSVKIHKYTVPTSVEILKGAEYYDPRVPVDGLKTGYTNQAGACLVATYRQNGHRMIATTLGGAWQFTANNNLRLMLKTTEQYKQVVPKSINYQIPGTQTKVRLVTKYNSKLWVNSKQPMTQTKIALWPLHRTAPNYLAANTAVLKLRLTDPLSGTTKEVIYRTPEALTMLGPLQWATAPAKRTTTGTYAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG7</accession>
    <name>F9UNG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889270.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1417"/>
    <dbReference type="EnsemblBacteria" id="CCC78756">
        <property type="protein sequence ID" value="CCC78756"/>
        <property type="gene ID" value="lp_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1417"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1188"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006135_1_0_9"/>
    <dbReference type="OMA" id="YHEVHLP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1217-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_27" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="825" mass="91959" checksum="487E0E707BBCC006" modified="2011-10-19" version="1">MQIKRLEIAGFGKFQQQQFEFGDGLQVIYGLNESGKSTMRAFILGMLFGFPSRRHPLERHEPQGTNQYGGSMELVVDETTYRLTRLGDQPATLVNVQTQAAQPLALLDKWLAPYDRDQYLRLFTFNQAELTALKTMRASDLNVQLQQVGLVGSAPWRETATTLRTDAEALYKPRGRKPRLNQALQHYRMLTEQVKAAKQRYPEYETLQNRLLDLQAQRTSTQRDLTKLDHEQQQLANLRNQWPVYQQLQQLQATNMTTTLTTATRTRYQQLSQQRTELQHALASARQQLSQQPVDTQSQGLVGFYVQHQDQFDQLEAQLPTLQQTLGQYQTLTQQGSAAKADFQAQSNAHPELLGCLSPHKQAAIETLKATLAATANTRRQHPAPNSPSLDWRLIGGAIGIVAGLLLPLGGFKWILMLAGVALLGWFGMTRSQGKPVQATDHLSDQLVAAGLAPNLTASEALQQLELVAALQRAQAAVTTADQALATQAAKLWQLIQPYQFAAGWIPVDQDHLTTSVTRIAQFYDQVHQVMQQQTMSGPDFAFVQRQVQQLTQQVRDLTEQLQALATTNGLADVDALTQAVSDAEKQTANATSRQQLQQQLSSAELSALKQYTSLEALQAVLAERQQQRTQTAQQLTQLATDIATAQAQLQELTADGQYATLRQQQADLQTEITVMARQWLTRQLGANWIDTALQALTQQQLPTVLAAATTIFAQLTAQRYNKIDLDGDEMVVKTATTQFMVVELSTATKEQLYLALRLALINHLGQAAQLPLMIDDGLVNFDEQRKQAAWQVLAAVAQHHQVLYFTNETAALTQLKTATVQQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN4</accession>
    <name>F9UNN4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">moaB</name>
        <name evidence="8" type="ordered locus">lp_1495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889337.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1495"/>
    <dbReference type="EnsemblBacteria" id="CCC78823">
        <property type="protein sequence ID" value="CCC78823"/>
        <property type="gene ID" value="lp_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="66449383"/>
    <dbReference type="KEGG" id="lpl:lp_1495"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1257"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_9"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="PhylomeDB" id="F9UNN4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1284-MON"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="7">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="17107" checksum="327A93D7AE12E667" modified="2011-10-19" version="1">MSRACILTVSDTRDLNTDKSGKLIAERLQHHGVTVMARHVVIDDIVDIQQQFLTFEQLGPDLIITNGGTGIAQRDVTITALTPLLPTMIPGFGEAFRELSFAEIGTRALASKAEAGFNNRNQLCYCLPGSTNACQTALDRLILPEFEHLLFERHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNX8</accession>
    <name>F9UNX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640353.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1603"/>
    <dbReference type="EnsemblBacteria" id="CCC78917">
        <property type="protein sequence ID" value="CCC78917"/>
        <property type="gene ID" value="lp_1603"/>
    </dbReference>
    <dbReference type="GeneID" id="57025187"/>
    <dbReference type="GeneID" id="66449487"/>
    <dbReference type="KEGG" id="lpl:lp_1603"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1352"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_9"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="PhylomeDB" id="F9UNX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1379-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="272" mass="29797" checksum="72AC156857D6234C" modified="2011-10-19" version="1">MEKERVDVLLVQQGLFDTREKAKRAVMAGEILGVNEERLDKPGMKIPVATELHLKGKPMPYVSRGGLKLEKALKSFEIDVTDKTVLDIGSSTGGFTDVVLQNGAKMSYALDVGSNQLVWKLRQDPRVVVMEHTNFRYSKLADFTQGQPNFASIDVSFISLHLILPPLHAIIENGGSVVALIKPQFEAGRENVGKHGIVRDPAVHQAVLTDIVEFAQANGYNVLGLDYSPIKGGEGNIEFLIHLQATDETPRIAPTVSIEKTQAAAYEQLNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB4</accession>
    <name>F9UPB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1763"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79053">
        <property type="protein sequence ID" value="CCC79053"/>
        <property type="gene ID" value="lp_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1763"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1487"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670474_0_0_9"/>
    <dbReference type="OMA" id="ICEREDW"/>
    <dbReference type="PhylomeDB" id="F9UPB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1517-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="410" mass="46741" checksum="CA98BEDB0092307F" modified="2011-10-19" version="1">MVDDGSTDGTATICDQYCARWPHLFRVIHQRNQGQGPARNAGITAAHGRYLGFVDADDWVEPTMYATLVATAERSHAQIVVCDVRKIYAATHRTTSLLSLPDATDHVAIATYLKYGLNNAYSGNKLYARSCWQKYRYQRMVYEDLDILLDMLSCCERVAYVQQPFYNYYKHAGSTTLDYTNPRLFDIMTAYQDAIEHAKVTYQDAVTYCVAKRILINLATPGFADYLAEFIELIRQLRPIFEASPSIMSDPAIKKICDYAGQLTLPRRFICEREDWAQSWHQYSRNFKTIIPVAKALPADLRQRSNHFKLDYWLLKTLFEQGGLLILGTVKLHRPFGRLRAGGDVLAFEGEHCLLVGAQPRSPLISELLQQLIVGSESLTELLTMVKAQPERWSAGTHKIRLVDIKDWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE2</accession>
    <name>F9UPE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640522.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889595.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1795"/>
    <dbReference type="EnsemblBacteria" id="CCC79081">
        <property type="protein sequence ID" value="CCC79081"/>
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    </evidence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2009-12" db="PDB data bank">
            <title>Crystal structure of Putative RNA-binding protein (NP_785364.1) from Lactobacillus plantarum at 1.45 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS)</scope>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="3KWR"/>
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</entry>
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    <accession>F9UPF6</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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            <dbReference type="EMBL" id="CCC79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
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    <accession>F9UPM6</accession>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF2929 family</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="RefSeq" id="YP_004889679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79165">
        <property type="protein sequence ID" value="CCC79165"/>
        <property type="gene ID" value="lp_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1900"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1601"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF2929"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79165.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7171" checksum="7DDFF450410DFC17" modified="2011-10-19" version="1">MMRQLTIIFWSVLFGEVIGYIGGALEQLSYNPGEIGIVAAIFALIVVNSITYITNHSQPAKGSDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPU8</accession>
    <name>F9UPU8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
            <ecNumber evidence="1">3.6.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EC" id="3.6.1.40" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889751.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1985"/>
    <dbReference type="EnsemblBacteria" id="CCC79237">
        <property type="protein sequence ID" value="CCC79237"/>
        <property type="gene ID" value="lp_1985"/>
    </dbReference>
    <dbReference type="GeneID" id="57025562"/>
    <dbReference type="KEGG" id="lpl:lp_1985"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1677"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_5_9"/>
    <dbReference type="OMA" id="HDAVYQR"/>
    <dbReference type="PhylomeDB" id="F9UPU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1701-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008894">
        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23029" checksum="97CD5B8F55826E03" modified="2011-10-19" version="1">MREFLWDLDGTLLDTYPAMVQAFQKAVAELGGTIPADTTYQLMRQQSVGYAERMVAAQYGWDWHDLRAGYQRWEPQLQHAPAAFAGAQAVLEKVIAVGGHNYLMTHRDESAQAYLQRAGLAQYFTDAVTAAQPFPRKPDPAALNYLLNKHQVDCQRAVMVGDRNLDIDAGHNAGIAGYLFDIDRLITVTSAPEVQVTDLNDLLTFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV2</accession>
    <name>F9UPV2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmE</name>
        <name evidence="7" type="ordered locus">lp_1989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889755.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1989"/>
    <dbReference type="EnsemblBacteria" id="CCC79241">
        <property type="protein sequence ID" value="CCC79241"/>
        <property type="gene ID" value="lp_1989"/>
    </dbReference>
    <dbReference type="GeneID" id="57025566"/>
    <dbReference type="KEGG" id="lpl:lp_1989"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1681"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_9"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="PhylomeDB" id="F9UPV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1705-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="26894" checksum="778BCAFA921126EC" modified="2011-10-19" version="1">MQRYFLSTPITTTIGQTFTITGETVKHWVKVMRAQPGDTAEFVTTTHQVVLADLVKSDGRTATATITAVTTPHVELPLPVTIACGLSKGDKPEQIVQRGTELGASAFVFFDSQWAVAKWAANKRARKLARLAKIAQGAAEQSHRTMIPSVSYATDLNQLLAHVSYDTGVVAWEESAKQGESSQLVQTLKTMTAPQRLLAIFGPEGGLAPQEVATLQTAGIAAVGLGPRIMRAETAPLYLLSSVSFWCELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPZ1</accession>
    <name>F9UPZ1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tyrA</name>
        <name evidence="9" type="ordered locus">lp_2034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889794.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2034"/>
    <dbReference type="EnsemblBacteria" id="CCC79280">
        <property type="protein sequence ID" value="CCC79280"/>
        <property type="gene ID" value="lp_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2034"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1719"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_2_1_9"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="PhylomeDB" id="F9UPZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1741-MON"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="365" mass="39132" checksum="2A767650010E2B7B" modified="2011-10-19" version="1">MTTVLIKGLGLIGSSLALSIKQAHPTVHIIGIDRDDVSLSYARQQGMIDASGTDLAAVASDADVIILAGPVDVIVADLHRLAMMPLKAGVLVTDVGSTKQVVMHAALAIQQHGVTFIGGHPMAGSHKSGVTAGRANLFENAFYLLVPGRTNQAAVQRLQALLQATHVKWLTVTAIQHDRIVGQLSHLPHIVAAALVDQTQVALADSALGLRLAAGGFKSITRIASSDPTMWAAILMTNAELITNQLQGYIDQLLRIKTAIRVHDQATLYEFFATAKVTRDHLGPEQLGGLPNFYDLFLNVPDRVGALADVTQRLAQAQLSLVNIHILEIREEIDGVLQLTFSDLKTRTQASSLLADAGYQIVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE2</accession>
    <name>F9UQE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, glucitol/sorbitol-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts17A</name>
        <name evidence="2" type="ordered locus">lp_2218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101685.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2218"/>
    <dbReference type="EnsemblBacteria" id="CCC79431">
        <property type="protein sequence ID" value="CCC79431"/>
        <property type="gene ID" value="lp_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2218"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1873"/>
    <dbReference type="eggNOG" id="COG3731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138435_1_0_9"/>
    <dbReference type="OMA" id="WITYEHR"/>
    <dbReference type="PhylomeDB" id="F9UQE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1892-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004716">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036665">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40398">
        <property type="entry name" value="PTHR40398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03829">
        <property type="entry name" value="PTSIIA_gutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141530">
        <property type="entry name" value="SSF141530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51097">
        <property type="entry name" value="PTS_EIIA_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="119" mass="12586" checksum="3785730FC4DC1BD4" modified="2011-10-19" version="1">MTITATVQSIGANAIDSKEPILVLFDETATAPLQQIAVIQKFEQPIASLSLVAGSTITIDRQTYTVALAGGLVEANLTSIGHATLYFKPVPAKPMENGIYLTPNQLPTIKVGSVITYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE7</accession>
    <name>F9UQE7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2223"/>
    <dbReference type="EnsemblBacteria" id="CCC79436">
        <property type="protein sequence ID" value="CCC79436"/>
        <property type="gene ID" value="lp_2223"/>
    </dbReference>
    <dbReference type="GeneID" id="57025746"/>
    <dbReference type="KEGG" id="lpl:lp_2223"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1878"/>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077095_2_1_9"/>
    <dbReference type="OMA" id="VWATIEH"/>
    <dbReference type="PhylomeDB" id="F9UQE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1897-MON"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
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        <property type="entry name" value="RelA_SpoT"/>
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            <begin position="43"/>
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        <location>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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    <accession>F9UQV9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890112.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2419"/>
    <dbReference type="EnsemblBacteria" id="CCC79598">
        <property type="protein sequence ID" value="CCC79598"/>
        <property type="gene ID" value="lp_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2419"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2045"/>
    <dbReference type="eggNOG" id="ENOG502ZZVZ">
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    </dbReference>
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    <dbReference type="OMA" id="IFKHANN"/>
    <dbReference type="PhylomeDB" id="F9UQV9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006528">
        <property type="entry name" value="Phage_head_morphogenesis_dom"/>
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    <dbReference type="Pfam" id="PF04233">
        <property type="entry name" value="Phage_Mu_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01641">
        <property type="entry name" value="phageSPP1_gp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="314" mass="35391" checksum="9685EEC2D177813C" modified="2011-10-19" version="1">MDINKLAHALAKILDVKDPVFQQLINIIEHSHHAQVKNLTYFLHKNVTWQDDADAADIKELTDTVLELKQSANREEEQVLATLLNNLPYKTNLDVAQAQARVNIANMGLKVNKLVQAKQADIVQQVTKLTGSGLGGYNKQLRHRALYRVAAQNEPENTSLDLIFKHANNLAIDLDNIIKFQMQNHVNPNSISKIVAKELGVAGKPNPNEDLWETAMQKRYMSTKADMERILVTESKATQTRECAKQYSNLGFTKLKIVTRDNPHVCRYCEGHDGTIVEIKDAVVGMNVPPFHPRCHCNVIPVQTDYKDVLSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW9</accession>
    <name>F9UQW9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2429"/>
    <dbReference type="EnsemblBacteria" id="CCC79608">
        <property type="protein sequence ID" value="CCC79608"/>
        <property type="gene ID" value="lp_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2429"/>
    <dbReference type="HOGENOM" id="CLU_3235301_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2094-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="43" mass="4991" checksum="BF03F2D8AE5D54C8" modified="2011-10-19" version="1">MKQIFEVIWNATPWQLVSWIGSIVLGVVIAFGLILLFLSMYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ6</accession>
    <name>F9UQZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2b protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101786.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890149.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2460"/>
    <dbReference type="EnsemblBacteria" id="CCC79635">
        <property type="protein sequence ID" value="CCC79635"/>
        <property type="gene ID" value="lp_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2460"/>
    <dbReference type="HOGENOM" id="CLU_2287943_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2127-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="101" mass="11498" checksum="0922ECC042DBB551" modified="2011-10-19" version="1">MNSFIKKWLFEVTLNITLLIVPAYLIVSSIFQDGPIVLCLSTPVPVFGIKLLTFNFMVLSVLDFLHWPSDYHEPKTIRKVIFVIHITIAVIALIISVRLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR13</accession>
    <name>F9UR13_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P2b protein 1, integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101803.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1062638"/>
    <dbReference type="EnsemblBacteria" id="CCC79652">
        <property type="protein sequence ID" value="CCC79652"/>
        <property type="gene ID" value="lp_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2480"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2088"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_6_9"/>
    <dbReference type="OMA" id="ITTIECQ"/>
    <dbReference type="PhylomeDB" id="F9UR13"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2144-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="385" mass="45171" checksum="707334387C362B3D" modified="2011-10-19" version="1">MATIKKYQDKDGNTRYQFQVYLGVDPLTGKKKNTRRRGFKTKKEAQIVLSRLELDIYNHGLPTKNDNTIFKDIYQLWFTQYKQTVKESTWVTTQRLFRLHILPIFSDYRIAKISIKDCQKAINQWFNAGLAKYHTLMNYVAKVLDYAINIDLISENPAKRVIVPVNKNDRSRKNLENYFDKAELQHFFECLTDDDNTPQASVFFRLAAFTGMRKSEMLCLEWSDIDFSNHTIRVNKTQSRGDGARLLVQAPKTARSNRTVYLDPTTIKILQHWQVDQKKWLLRFGFNINQGNHYVFANENNEMFQPSKPRKWLEHTLTKYDLKHVTVHAFRHTYATLAFEAHASIKSVQDQLGHSSYRTTLDIYTAVTAKQKNEATEKLANYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR33</accession>
    <name>F9UR33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101808.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2504"/>
    <dbReference type="EnsemblBacteria" id="CCC79672">
        <property type="protein sequence ID" value="CCC79672"/>
        <property type="gene ID" value="lp_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2504"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2109"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_1_2_9"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="PhylomeDB" id="F9UR33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2164-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_3" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="165"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="393" mass="43758" checksum="69FC7D8E615572AB" modified="2011-10-19" version="1">MQRVQITGNSQRKVKDGYPLLVQDDLKDPSMKLTDGSFVALMASSQFMGYALIAKHRRQLGWVLSLDESETPTTDYFRKLFKQALVRRATSMDPQLPQRVFNADGDGLGGLAIDRYQDYYVFTWYAQGVYQQREMIYAAFEAATEHQFKGIYAKLRFNVEEANLKSQLVTGEAAPEPLLVTEGAVTYPLHLADDLTTGLLLDMRPIREWLAGAELQGKTVLNLFSQENGVTAAAAVAGAAKTISIETSKKGAKETADQLAVNNIDPDKQEIRAIEVNSYLDYAQKHRLSYDVVVVTAPTFARVKKQKFQVATDLTDLLTATLPVVRRDGQLVIATTANNFSMKKFKAAVTAAFVGSDRHFTLSETFRLPADFVTRKAYLASNYLKVLVLTLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC9</accession>
    <name>F9URC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101859.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79768">
        <property type="protein sequence ID" value="CCC79768"/>
        <property type="gene ID" value="lp_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2630"/>
    <dbReference type="eggNOG" id="ENOG5030A39">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1904051_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2259-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="131" mass="15271" checksum="BA268C6A6DD77B72" modified="2011-10-19" version="1">MMKDKAINILTAELSALPVLIMTYYALTAKPTGQWQLTFSLPVYWLISSDLLAYPWLLTRIPRLRHNPLKMNSLALKASSRYNCRLNERVARWDDEMNLAIFLLERGCLMLLSEPLLLGDLGYHSVRRLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL2</accession>
    <name>F9URL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-asparaginase</fullName>
            <ecNumber evidence="10">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890365.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URL2"/>
    <dbReference type="STRING" id="220668.lp_2738"/>
    <dbReference type="EnsemblBacteria" id="CCC79851">
        <property type="protein sequence ID" value="CCC79851"/>
        <property type="gene ID" value="lp_2738"/>
    </dbReference>
    <dbReference type="GeneID" id="57026111"/>
    <dbReference type="GeneID" id="66450388"/>
    <dbReference type="KEGG" id="lpl:lp_2738"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2291"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_1_0_9"/>
    <dbReference type="OMA" id="RKNHTSR"/>
    <dbReference type="PhylomeDB" id="F9URL2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2342-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="9">
        <location>
            <begin position="204"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="34446" checksum="05A4ACD74654E2BE" modified="2011-10-19" version="1">MKKILVLHTGGTIAMSADESGNVTPGDENPLDNYQSSFGTDIELETEDVFNVPSPHITPARMLQLKQRIDKAAHEGVDGVVVTHGTDTLEETAYFLDLTLPNELPVVITGAMRSANEIGSDGLHNLETAIQTASTPDAAEKGVLVVMNDEIHSARYVTKTHTTNVATFRTPTFGPIGLVANKGIVFFESLLRSTVCPIQTVTDNVFLIKAYAGMGPELFDAIAQPTTHGVVIEALGAGNLPPATLPAVQKLLDMQIPVVLVSRCFNGIAQDVYAYEGGGVQLKQMGVIFCQGLNGQKARIKLLVGVSAGMSTDELARFVATANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP0</accession>
    <name>F9URP0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, biotin repressor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101910.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890393.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2770"/>
    <dbReference type="EnsemblBacteria" id="CCC79879">
        <property type="protein sequence ID" value="CCC79879"/>
        <property type="gene ID" value="lp_2770"/>
    </dbReference>
    <dbReference type="GeneID" id="57026140"/>
    <dbReference type="GeneID" id="66450417"/>
    <dbReference type="KEGG" id="lpl:lp_2770"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2319"/>
    <dbReference type="eggNOG" id="COG1827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108798_0_0_9"/>
    <dbReference type="OMA" id="HTPEQTK"/>
    <dbReference type="PhylomeDB" id="F9URP0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2370-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035922">
        <property type="entry name" value="3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004173">
        <property type="entry name" value="3H_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026043">
        <property type="entry name" value="NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40068">
        <property type="entry name" value="PTHR40068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02829">
        <property type="entry name" value="3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037847">
        <property type="entry name" value="NiaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF75500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="3">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="3H" evidence="2">
        <location>
            <begin position="71"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037847-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="18701" checksum="AFB755F1C21B8A2C" modified="2011-10-19" version="1">MTGSERREQIRSKLSQTQIPVSATTLAKQFNVSRQTIVGDISLLRAHGTAIVATLQGYELEKADQPTAVLVCRHFPNEAMQEMALIIHAGGIIKDVEVEHPLYGRLRGELEIRSVGDVNLFMGRLKKLQGHLLSELTDGVHSHTVAYQTPEQLTAIKAALRDAGYLYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX6</accession>
    <name>F9URX6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2877"/>
    <dbReference type="DNASU" id="1063265"/>
    <dbReference type="EnsemblBacteria" id="CCC79965">
        <property type="protein sequence ID" value="CCC79965"/>
        <property type="gene ID" value="lp_2877"/>
    </dbReference>
    <dbReference type="GeneID" id="57026243"/>
    <dbReference type="GeneID" id="66450505"/>
    <dbReference type="KEGG" id="lpl:lp_2877"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2408"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="FRFAMNR"/>
    <dbReference type="PhylomeDB" id="F9URX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2462-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16287" checksum="96FE7CF4EBF75CA5" modified="2011-10-19" version="1">MSEMSPKEFKHILVGVDDSDDAQLAFRYAINRAKSDGAKLTIVSILEQDNMNVYEAMSKDFVHGQRKDLEEHVQQYQKLARDFGVTDVNAVVDEGDPGETIVKTVIPALKPDLLVIGSVAKHGVRKYFGSQAAYMAKHAPISVLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ6</accession>
    <name>F9URZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-entry nuclease</fullName>
            <ecNumber evidence="4">3.1.30.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">endA</name>
        <name evidence="4" type="ordered locus">lp_2906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.30.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101964.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890499.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2906"/>
    <dbReference type="EnsemblBacteria" id="CCC79985">
        <property type="protein sequence ID" value="CCC79985"/>
        <property type="gene ID" value="lp_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2906"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2427"/>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054350_3_0_9"/>
    <dbReference type="OMA" id="GNELMPR"/>
    <dbReference type="PhylomeDB" id="F9URZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2481-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044927">
        <property type="entry name" value="Endonuclea_NS_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13930">
        <property type="entry name" value="Endonuclea_NS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394310" evidence="2">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease_NS" evidence="3">
        <location>
            <begin position="95"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="34320" checksum="E51535E671257895" modified="2011-10-19" version="1">MVKLMRRVGIAGLLSLSLLLGGCSLLTSGTDTTSSTTSQQSESSRNQTTSATGNTQQTYKQLAKMTYQSGSAAAIKVNSGKSTLAASQWKNSKIDYGNLDSLNRTTTDTAYLSKANLGRSEGRTAQTWSPTGWHNQPITVNGKRVYPQNRGHLIAYTLSFNLTSNGQYRASEDGSLDNPKNLATQTAYSNQKTMQIYEDQVRTALEQGKKVIYRVTTVFRGNELMPRGYWSQAVSTDGSVNFNVYIWNVEPGVSFDYATGRGKADSTMQVAGADKVSSSQNTSTSRSSQSTTTSKQVERELVKYGYKYVKKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ8</accession>
    <name>F9URZ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2909"/>
    <dbReference type="DNASU" id="1063301"/>
    <dbReference type="EnsemblBacteria" id="CCC79987">
        <property type="protein sequence ID" value="CCC79987"/>
        <property type="gene ID" value="lp_2909"/>
    </dbReference>
    <dbReference type="GeneID" id="57026260"/>
    <dbReference type="GeneID" id="66450522"/>
    <dbReference type="KEGG" id="lpl:lp_2909"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2429"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_9"/>
    <dbReference type="OMA" id="FIDYLAH"/>
    <dbReference type="PhylomeDB" id="F9URZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2483-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="175" mass="19716" checksum="80EACD474F6D629C" modified="2011-10-19" version="1">MTQFETERLILRPMTAADHDALADMIFDPQVVAYLRYRRVQSPAAFEQLFTTHFLADTTTVFGIERRRDHQLIGFYEFHGSGATGELTYALSPAAWGHGYVAEAGNCLMHYGFETLNYETIEAHYASANPNSGRVMAKMGMQAAGELHTFTSDKGEVIHVMRYLLTKATWRQLSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9US27</accession>
    <name>LPDC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gallate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gallate decarboxylase catalytic subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protocatechuate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.63</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lpdC</name>
        <name evidence="6" type="synonym">ubiD</name>
        <name evidence="6" type="ordered locus">lp_2945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Appl. Environ. Microbiol." volume="79" first="4253" last="4263">
            <title>Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation.</title>
            <authorList>
                <person name="Jimenez N."/>
                <person name="Curiel J.A."/>
                <person name="Reveron I."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
            </authorList>
            <dbReference type="PubMed" id="23645198"/>
            <dbReference type="DOI" id="10.1128/AEM.00840-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in tannin degradation. Catalyzes the decarboxylation of gallic acid and protocatechuic acid to pyrogallol and catechol, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2</text>
            <dbReference type="Rhea" id="RHEA:12749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16164"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16918"/>
            <dbReference type="EC" id="4.1.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3,4-dihydroxybenzoate + H(+) = catechol + CO2</text>
            <dbReference type="Rhea" id="RHEA:22416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="EC" id="4.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN (prenyl-FMN) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="induction">
        <text evidence="5">By gallic acid.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells lacking this gene are unable to decarboxylate gallic acid and protocatechuic acid.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Gallate decarboxylase does not form a complex composed of Lpdc, LpdB and LpdD. The term subunit has been used in reference to the three-gene operon. Gallate decarboxylase LpdC is the only protein required to yield the gallate decarboxylase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.59" evidence="2"/>
    <dbReference type="EC" id="4.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890530.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9US27"/>
    <dbReference type="SMR" id="F9US27"/>
    <dbReference type="STRING" id="220668.lp_2945"/>
    <dbReference type="EnsemblBacteria" id="CCC80016">
        <property type="protein sequence ID" value="CCC80016"/>
        <property type="gene ID" value="lp_2945"/>
    </dbReference>
    <dbReference type="GeneID" id="57026287"/>
    <dbReference type="GeneID" id="66450552"/>
    <dbReference type="KEGG" id="lpl:lp_2945"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2459"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_9"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="PhylomeDB" id="F9US27"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2512-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-19902"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018798">
        <property type="term" value="F:gallate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050223">
        <property type="term" value="F:protocatechuate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444026" description="Gallate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AAB4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="490" mass="54259" checksum="266E54023E02B8AD" modified="2011-10-19" version="1">MAEQPWDLRRVLDEIKDDPKNYHETDVEVDPNAELSGVYRYIGAGGTVQRPTQEGPAMMFNNVKGFPDTRVLTGLMASRRRVGKMFHHDYQTLGQYLNEAVSNPVAPETVAEADAPAHDVVYKATDEGFDIRKLVAAPTNTPQDAGPYITVGVVFGSSMDKSKSDVTIHRMVLEDKDKLGIYIMPGGRHIGAFAEEYEKANKPMPITINIGLDPAITIGATFEPPTTPFGYNELGVAGAIRNQAVQLVDGVTVDEKAIARSEYTLEGYIMPNERIQEDINTHTGKAMPEFPGYDGDANPALQVIKVTAVTHRKNAIMQSVIGPSEEHVSMAGIPTEASILQLVNRAIPGKVTNVYNPPAGGGKLMTIMQIHKDNEADEGIQRQAALLAFSAFKELKTVILVDEDVDIFDMNDVIWTMNTRFQADQDLMVLSGMRNHPLDPSERPQYDPKSIRFRGMSSKLVIDGTVPFDMKDQFERAQFMKVADWEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9US42</accession>
    <name>F9US42_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888103.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0012"/>
    <dbReference type="DNASU" id="1061126"/>
    <dbReference type="EnsemblBacteria" id="CCC77589">
        <property type="protein sequence ID" value="CCC77589"/>
        <property type="gene ID" value="lp_0012"/>
    </dbReference>
    <dbReference type="GeneID" id="57026873"/>
    <dbReference type="KEGG" id="lpl:lp_0012"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.10"/>
    <dbReference type="eggNOG" id="COG3887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018278_0_0_9"/>
    <dbReference type="OMA" id="STCELVT"/>
    <dbReference type="PhylomeDB" id="F9US42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-10-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106409">
        <property type="term" value="F:cyclic-di-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="183"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="670" mass="75995" checksum="EE6B796EB6E52249" modified="2011-10-19" version="1">MKKIFSREKIPFFLQNQQLRLLALVIFSLSLIMLVTGYLMNWIFGTVVLILIVMAVVISYNTLIELSSSANEYISDLSYRIKRGEQEALIQMPIGVMIFNSDQTIEWINPYLQRYFGDKDVLGYRLEDIEPTLAATLNAHLDEPATIRWQDYQFDVRVQQSTNTVYMMDVTKYAELTDQFEDEKLVIGQIFLDNYDEITQSMTDTDISNLNNYVTNELSKWTQMFGMYLKRLDDDHFFLLGYASSLRRVEENKFRILDRIRESTSKQNFPLTLSIGIAYGERNMNNLADLAQSNMDLALGRGGDQVVVKSEDEPARFYGGKTNPMEKRTRVRARMISQTLQELMNQSDQIFVQGHRQPDMDAVGACLGIRRIAEMNGKQCWIVLDEQNVHSDIQRLLDQLKSDENIESAIISPEEALEKATDQSLLIMADHSKPSISMSQALYERLENRVMIIDHHRRGEEFPENPVLVYIEPYASSTCELITEMFEYQSHDAEPINKIEATAMLTGIVIDTKSFSLRSGSRTFDAASYLRSAGADSLLVQQFMKENVDSYLQRNHLIETVEFVNQDMALCVGEDDQVYDPVTAAQAADSLLSMSGVDASFVITRREDGRVGISARSLGEINVQVYMEKLGGGGHLSNAATQIEGQSVEAVKQSLIDLLTATDEPTTESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB8</accession>
    <name>F9USB8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80048">
        <property type="protein sequence ID" value="CCC80048"/>
        <property type="gene ID" value="lp_2987"/>
    </dbReference>
    <dbReference type="GeneID" id="57026319"/>
    <dbReference type="GeneID" id="66450586"/>
    <dbReference type="KEGG" id="lpl:lp_2987"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2493"/>
    <dbReference type="eggNOG" id="ENOG5030AFD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183692_0_0_9"/>
    <dbReference type="OMA" id="EANNHDT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2543-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="72" mass="8197" checksum="9A74E9E12F209D40" modified="2011-10-19" version="1">MAAAVEMNSMLDEKMTDVFDWSDSKLPVRDAIWNHFMDADSHDTDKTADEVAPYMSMDEAKLKSEVEKLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE0</accession>
    <name>F9USE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890584.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3013"/>
    <dbReference type="EnsemblBacteria" id="CCC80070">
        <property type="protein sequence ID" value="CCC80070"/>
        <property type="gene ID" value="lp_3013"/>
    </dbReference>
    <dbReference type="GeneID" id="57026340"/>
    <dbReference type="KEGG" id="lpl:lp_3013"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2516"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_9"/>
    <dbReference type="OMA" id="MPHIDRS"/>
    <dbReference type="PhylomeDB" id="F9USE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2564-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16546" checksum="2B113F21B3EE0010" modified="2011-10-19" version="1">MTYTIKEVADKVGLSAYTLRFYDKQGLLPFVSRNESGYRAFTDGDLHLLHTIICLKNTGMAISAIRQYISYVMAGPQSIAQRRELLTTHRNAILAQQAQIMKNLKEVDYKLNLYSDPHARELVQGEIAQAKSEKQALGLADPFPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF6</accession>
    <name>F9USF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, subgroup 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890600.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3029"/>
    <dbReference type="EnsemblBacteria" id="CCC80086">
        <property type="protein sequence ID" value="CCC80086"/>
        <property type="gene ID" value="lp_3029"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3029"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2532"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="NWNNSAD"/>
    <dbReference type="PhylomeDB" id="F9USF6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2579-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="23569" checksum="263E831C67AD50EA" modified="2011-10-19" version="1">MKKVILLGATSNISKYLIPRLLAKNDVELTLFARQATRRLHQYAAQSQVTLTNGNWNNSADLTAAIAGQDIVYLATGHFTTANQNVVDAMKQNGVERLIVAGGLGIYDEVAGKFGIWNAQMMGDYTEIKRAAAVIDNSGLNYTFLRMAWLYNNDQHTDYKVIPQGMPFKDTQVTRQAVADLITEIIHNPQLYQRSSIGVAEPNTAWNKPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF9</accession>
    <name>F9USF9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USF9"/>
    <dbReference type="STRING" id="220668.lp_3032"/>
    <dbReference type="DNASU" id="1062928"/>
    <dbReference type="EnsemblBacteria" id="CCC80089">
        <property type="protein sequence ID" value="CCC80089"/>
        <property type="gene ID" value="lp_3032"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3032"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2535"/>
    <dbReference type="eggNOG" id="COG4925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099043_3_0_9"/>
    <dbReference type="OMA" id="YWTPRHS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2582-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="117" mass="13415" checksum="6E22FD6B42F44CFF" modified="2011-10-19" version="1">MKKMKITANDRHFTANLEENATTAALLSQLPLTLPMLNLYNRELTYRFQQALPANEAHTTGYAVGDIAYWTPRHSLVIFYEQTGEVISNLQKIGHINAGDLKQFRSSRNIKMQFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI6</accession>
    <name>F9USI6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Medium-chain degydrogenase/reductase, Qor family</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890630.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3069"/>
    <dbReference type="DNASU" id="1063567"/>
    <dbReference type="EnsemblBacteria" id="CCC80116">
        <property type="protein sequence ID" value="CCC80116"/>
        <property type="gene ID" value="lp_3069"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3069"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2563"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_9"/>
    <dbReference type="OMA" id="VWTNSMG"/>
    <dbReference type="PhylomeDB" id="F9USI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2609-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="322" mass="34749" checksum="36C9503183A33E5C" modified="2011-10-19" version="1">MKAVIFDDFGSPDVLRIADVQRPVATTATVLVKVMAVAVNHVDTFVRSGTFKTALAAPHVAGRDLVGEVVASSQPDFQIGDQVWTNSMGYEGRMGATAEYVAVPTDRLYHVPDGVAPMPLVAAVHSAATAAIVLNDVMEICSGQTLLIEGAAGNVGRKLIQLAHQMGVTVVITASPRDFARCQQLGSTACYDYHAGFADQLTTDQWTFDHVIDTSGRVPLAINLALLRLGGQVTLITAPQDNQFEFPVRQFYMSQQRITGFVISHATVDQLAQAASRLNRAFSAGLLLDDQVSQRYFKDAAQCHAQLEAGTDHHQRFVLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK7</accession>
    <name>F9USK7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysozyme/muramidase, glycoside hydrolase family 25</fullName>
            <ecNumber evidence="7">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890651.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3093"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80137">
        <property type="protein sequence ID" value="CCC80137"/>
        <property type="gene ID" value="lp_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3093"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2583"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016570_0_0_9"/>
    <dbReference type="OMA" id="AQHYVKI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2630-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08460">
        <property type="entry name" value="SH3_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394414" evidence="5">
        <location>
            <begin position="50"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="471"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="635"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="719"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="799"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="860" mass="89632" checksum="4DAC7A298BF90F1C" modified="2011-10-19" version="1">MNFKSQNPIDASQSERFKLYKSGKLWLVAGLTFFSFLGGSVLNDTNVHADATNATTTSSSAASTASSASVATSSAASDETTKATSVSSSAATQVTSAATTKTTSQAATASSSAATSQSTSTASSSTSQATKTASSAATSTSATATSQATSVASSTATTTQVSHTASSTAASAASSTATVKAVKAASSTVSSAATTATKATAKVAAVAYTAATTSSTDVWTIGDTTRPRVDVVDVASYQSTMTQSDFNKLKAAGVKTVIVKSTEGTDYTNPAALNQAKMANKAGLNVDFYHYATFSTADAAKSEATNMAGFLVKNNVSTKVLLFADMEDSSSYSVNATANLNAFWSTLDSFGYKNHGVYTSNSYLYRDAVVKTVGQSRVWRAQYPYTPSANNLWNTNDGAWQFSDTALLPSGSDYTGYIDVSIDYNGLTEDSAGTNTFVTTTSSNDTTTSEVTTDTSATTNTSTSSTTKKASGWYTFTKNTAIKSAASDSAKTVGTYSKGNRVYYNAEITTNGETWLRYLSYSGSEHFVKIAAAKTTTTKPAASTSKTVTKNETGTYKFTKTTAIKGSVSDSAKTLGTYYKGDTVYYNAKVTKNGETWLRYLSYSGAQHYVKISGAATSTTTTKPATSSSKTVTKAETGTYKFTGTTAIKGSVNDSAKTLGTYYKGDTVYYNAKVTKNGQTWLRYLSYSGAQHYVKISGAATTTTTSSKSTATASAKTVAQSGTYKFAKTTAIKSSASDAASTVGTYYKGNTVNYNAKVTTNGQTWLRYTSYSGAQHYVKVSGGAATTTSSSASKTTAAAGTYTFKTTTNIRTAASLNASVVGQYSAGESVYYIGTVSADGYQWLKYLSNSGAYHYVAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP1</accession>
    <name>F9USP1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator, BglB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bglG3</name>
        <name evidence="2" type="ordered locus">lp_3131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890685.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3131"/>
    <dbReference type="EnsemblBacteria" id="CCC80171">
        <property type="protein sequence ID" value="CCC80171"/>
        <property type="gene ID" value="lp_3131"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3131"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2619"/>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078802_0_0_9"/>
    <dbReference type="OMA" id="WEIKNYY"/>
    <dbReference type="PhylomeDB" id="F9USP1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2664-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="172"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="30794" checksum="5794FAE99B17DC70" modified="2011-10-19" version="1">MLRIKKVLNSSVVLVTDEHDQEFILLGKGIGYGKKTGAVIMDGDFNQVFVASPDPNVEQLLATIASSSPQLIEITQTIVSEATEQLQSKLSDTLYVALLDHLKFTLERAAKGIVITNRVYWEIKTYYSHEFEIGQLAVRLVNRAFKTDFSEQEAANIAAHIINAENGTDERKDALKAGQLIGRIINIVKYQTGGIVNEHDLNYQRCVVHVKFLVERAIAGELLDDADPAMVAIVKSQNSRAFAIAGKVAAYMSMKFKMPLPDEEVMLMAMQIQRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR3</accession>
    <name>F9USR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888158.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0080"/>
    <dbReference type="EnsemblBacteria" id="CCC77644">
        <property type="protein sequence ID" value="CCC77644"/>
        <property type="gene ID" value="lp_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="57026929"/>
    <dbReference type="KEGG" id="lpl:lp_0080"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.66"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_2_9"/>
    <dbReference type="OMA" id="QTWREAY"/>
    <dbReference type="PhylomeDB" id="F9USR3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-66-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="19073" checksum="2B63C7E3DA155018" modified="2011-10-19" version="1">MALTYRIVRAEADSDFGKIRQLYYETWQSAYRDLMPASYLQQLTPATWRPERRWQNMLLAMTADGEVVGVCTFGPARHANYEGWGELYSLYVHPNYHHHGIGQQLIIQAHRRLKAVYPQNYLLVLANNAVAQRFYQRNGFHDTGQIYVDHAPFGVLHERIFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR6</accession>
    <name>F9USR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0083"/>
    <dbReference type="EnsemblBacteria" id="CCC77647">
        <property type="protein sequence ID" value="CCC77647"/>
        <property type="gene ID" value="lp_0083"/>
    </dbReference>
    <dbReference type="GeneID" id="57026932"/>
    <dbReference type="KEGG" id="lpl:lp_0083"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.69"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_8_1_9"/>
    <dbReference type="PhylomeDB" id="F9USR6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-69-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="11943" checksum="4AA5C4099C26793A" modified="2011-10-19" version="1">MAERTMAIFKKGVPIFTILQDENRQRILVMLCRTDQMTVNQITAQIALSRPAVSHHLKLMLDAGILAVSKTGTERYYRANMTATLKLLKALTASLEADLAHTQSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ1</accession>
    <name>F9USZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase, maltodextrins and cyclomaltodextrins</fullName>
            <ecNumber evidence="2">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malS</name>
        <name evidence="2" type="ordered locus">lp_0179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-06" db="PDB data bank">
            <title>Crystal structure of an alpha-amylase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Bonanno J.B."/>
                <person name="Dickey M."/>
                <person name="Bain K.T."/>
                <person name="Iizuka M."/>
                <person name="Ozyurt S."/>
                <person name="Smith D."/>
                <person name="Wasserman S."/>
                <person name="Sauder J.M."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 3-440</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3DHU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C/D=3-440"/>
    </dbReference>
    <dbReference type="PDBsum" id="3DHU"/>
    <dbReference type="SMR" id="F9USZ1"/>
    <dbReference type="STRING" id="220668.lp_0179"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="DNASU" id="1061459"/>
    <dbReference type="EnsemblBacteria" id="CCC77722">
        <property type="protein sequence ID" value="CCC77722"/>
        <property type="gene ID" value="lp_0179"/>
    </dbReference>
    <dbReference type="GeneID" id="57027009"/>
    <dbReference type="KEGG" id="lpl:lp_0179"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.147"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032719_0_0_9"/>
    <dbReference type="OMA" id="VFMLAEW"/>
    <dbReference type="PhylomeDB" id="F9USZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-144-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041331">
        <property type="entry name" value="Bac_A_amyl_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18612">
        <property type="entry name" value="Bac_A_amyl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="16"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3DHU"/>
        </source>
    </evidence>
    <sequence length="440" mass="49915" checksum="89CEB4925B2D3F0A" modified="2011-10-19" version="1">MARDTQTQLRNEMIYSVFVRNYSEAGNFAGVTADLQRIKDLGTDILWLLPINPIGEVNRKGTLGSPYAIKDYRGINPEYGTLADFKALTDRAHELGMKVMLDIVYNHTSPDSVLATEHPEWFYHDADGQLTNKVGDWSDVKDLDYGHHELWQYQIDTLLYWSQFVDGYRCDVAPLVPLDFWLEARKQVNAKYPETLWLAESAGSGFIEELRSQGYTGLSDSELYQAFDMTYDYDVFGDFKDYWQGRSTVERYVDLLQRQDATFPGNYVKMRFLENHDNARMMSLMHSKAEAVNNLTWIFMQRGIPLIYNGQEFLAEHQPSLFDRDTMVADRHGDVTPLIQKLVTIKQLPLLRAADYQLAVVEEGIVKITYRAAGEALTAWIPLKGQVTAVATKLAAGSYQNLLTDGPTEVVDGKLTVDGQPVLIKYVTNTAVTKVADQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT20</accession>
    <name>F9UT20_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0215"/>
    <dbReference type="EnsemblBacteria" id="CCC77751">
        <property type="protein sequence ID" value="CCC77751"/>
        <property type="gene ID" value="lp_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0215"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.178"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_3_9"/>
    <dbReference type="OMA" id="LNYLAMM"/>
    <dbReference type="PhylomeDB" id="F9UT20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-173-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="269"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="506" mass="56125" checksum="A5DD15E6B518D3E2" modified="2011-10-19" version="1">MTMINLKNIQKDMAGRPLFTIDRLVANAGDKIGVVGRNGAGKSTLAHLLTGTDRDYTGQIMVDEPVSYVAQIAPTFDQSGGQAMLTRIRQALSARPTILILDEPSSNLDETHQQWLINQLQRFRGLLLLISHDRQLLNAVTTQTWAVEHQKFTAYAGNYAYYQTVKAQQLATQEAAYQRQNTHQRELLAAQRQRNEKAQRIRKGNRRMSQVERAKTKATREATAAKMERTAKRMVARGQREPQVAKPFTTSGFKLVATDFPTFTGKTVVTGLNVTLAEYGKTLLAHADFQIRPHDRVAIVGPNGSGKTTLLRAILGGRVSGLRLAPAARVGVFNQDMTVLDGKQSVWQTVRQVSQLPDQTIRNVMGALGLPARFYPQLVSALSGGELVKLQLICILVGQYNVLMLDEPTNYLDVDALDALADYLQNYPGTVIFVSHDEPFRQAVATRVLQFETHQLVDPDKVVKAPQPVEADLAVLQFKYDQLMADPTSSTAAIQALRQQIDRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT24</accession>
    <name>F9UT24_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0219"/>
    <dbReference type="EnsemblBacteria" id="CCC77755">
        <property type="protein sequence ID" value="CCC77755"/>
        <property type="gene ID" value="lp_0219"/>
    </dbReference>
    <dbReference type="GeneID" id="57027042"/>
    <dbReference type="GeneID" id="66448333"/>
    <dbReference type="KEGG" id="lpl:lp_0219"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.182"/>
    <dbReference type="eggNOG" id="COG4721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089225_2_0_9"/>
    <dbReference type="OMA" id="GVIFWAW"/>
    <dbReference type="PhylomeDB" id="F9UT24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-177-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037394">
        <property type="entry name" value="ABC_thiamine-permease_YkoE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="20808" checksum="1E2168370D367365" modified="2011-10-19" version="1">MKWVKSWYLNDIILLALIGIFFGAIFMGTNFVYNILSAALTPFGLSGLANELLLGLWCMPGMLAGYLIRLKGSATLGELLAATVEMFFGGQWGITTLISGVVQGFGAELGYIVTGYKHYDWLGLTAAAATTTVVTFGWDLARNGYYKLQLWLLILYVVVRFISMFVFGGLLTKTITDLLDRSHVLKSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT58</accession>
    <name>F9UT58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888303.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0261"/>
    <dbReference type="EnsemblBacteria" id="CCC77789">
        <property type="protein sequence ID" value="CCC77789"/>
        <property type="gene ID" value="lp_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0261"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.216"/>
    <dbReference type="eggNOG" id="ENOG50348MC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2382657_0_0_9"/>
    <dbReference type="OMA" id="IWIDALV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-211-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="10688" checksum="5A046C68A4849B50" modified="2011-10-19" version="1">MSDFKGILLGMLVVAVLYMLDRYLPRWFGAIPGAGFLGFIIYIVFTKEVSLLSIVTVLLVGEAVLNGIWIDALVNRKRKMKKEVATMKAKDLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT95</accession>
    <name>F9UT95_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="WFNEWMR"/>
    <dbReference type="PhylomeDB" id="F9UT95"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2701-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="116" mass="13222" checksum="AF54B5D83C52E540" modified="2011-10-19" version="1">MQSVSSMSSMDHFWLVIFCACVAFIPRFFPLLFFTKRKIPKWFNEWMRFVPVSLFTALVVKSVFIDSKYAVITSGNLGMIISAILVGFVAYRTRSMTLSVVIGLVSVMIFVLLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE2</accession>
    <name>F9UTE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">lp_3243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3243"/>
    <dbReference type="EnsemblBacteria" id="CCC80260">
        <property type="protein sequence ID" value="CCC80260"/>
        <property type="gene ID" value="lp_3243"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3243"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2708"/>
    <dbReference type="HOGENOM" id="CLU_177699_0_0_9"/>
    <dbReference type="OMA" id="YFESANF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2748-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="85" mass="10003" checksum="D380529A2FB5B41C" modified="2011-10-19" version="1">MNKERKLIYVILNDEDVEYDLEELPDQYVVYIRQQAGDSRDLSLVNTEIQNLFKDAELDFEEKIKPENRKADIVLAVKRSTVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ9</accession>
    <name>F9UTJ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, histidine triad family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890831.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3319"/>
    <dbReference type="EnsemblBacteria" id="CCC80317">
        <property type="protein sequence ID" value="CCC80317"/>
        <property type="gene ID" value="lp_3319"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3319"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2768"/>
    <dbReference type="eggNOG" id="COG0537">
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    <dbReference type="HOGENOM" id="CLU_123330_1_1_9"/>
    <dbReference type="OMA" id="VWPRFEW"/>
    <dbReference type="PhylomeDB" id="F9UTJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2808-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIT-like"/>
    </dbReference>
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        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="19854" checksum="E572E302BAFDF9BB" modified="2011-10-19" version="1">MTSTCTICERIKLIQAHQNPYFVYELTTGYVVLADSQYFEGYTLFLAKHHVTELHHLPAHEKLRYLEEMSIVQEACAQAFHADKMNIELLGNGDAHVHWHLFPRHNGDTPNPGPVWWTPLETIYGDDVSLDIPRLSRLKRTLSVAIEATLNAREAELQALEALTRPASHRIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK8</accession>
    <name>F9UTK8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0751 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102112.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890840.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3333"/>
    <dbReference type="EnsemblBacteria" id="CCC80326">
        <property type="protein sequence ID" value="CCC80326"/>
        <property type="gene ID" value="lp_3333"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3333"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2778"/>
    <dbReference type="eggNOG" id="ENOG5033ERN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709391_0_0_9"/>
    <dbReference type="OMA" id="HNETSGH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2816-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016772">
        <property type="entry name" value="UCP020408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10087">
        <property type="entry name" value="DUF2325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="394" mass="44091" checksum="03505BC90C3A5B8C" modified="2011-10-19" version="1">MKKYRDYRTAIARTLTMIQPTDEGLAKGAKAIQEILNLALDPDTIVDSDNTRIARLATSNAHNETSGHATQANAEDSSSSVKTTSAQSNGQTIMQVKRDLKGFDLVDPNDPTVTPRYHYDEILARQLVIHHDDQVLLEQNLRQHRQPYIDKIVSHATTADPITVAAFFVVHYQDTDDTYHIEQDYNGTTLSSLNPAMNDVTFTSQEAQYQRISNGQLVDLAWYKERPEKVVIRYVHHSSSQPTSNKAAKPAKKATIHTTTVPVTLRTLDFDLHEKTVAIVMGDVGTRRTQITQLIDEHNGHTLLIDAFKHSNSTNFYYRQIGQADLVVMIQNQNKHATSKTLNKAVKHYGIKMTIADGGGLQQIERAVYRGIADLPAYESGNPISYPRINDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM8</accession>
    <name>F9UTM8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890860.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80346">
        <property type="protein sequence ID" value="CCC80346"/>
        <property type="gene ID" value="lp_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3356"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2799"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_3_0_9"/>
    <dbReference type="OMA" id="DEIDEYC"/>
    <dbReference type="PhylomeDB" id="F9UTM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2835-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="17327" checksum="5185FBE42BD2CEB7" modified="2011-10-19" version="1">MNLKWYVKQFNGLTTTQLHDIYQLRAKTFIKEQDRSYQDPDDTDLNARHVFAYDQGQLVAYARIYEHAGVVSFGRITTDSCYRGTGLGKQLMNHVMAILKVHYSAATIEIDAQTHAQKFYEKFGLIAEGQPYIDLGAEVIKMHAPARKLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX8</accession>
    <name>F9UTX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643788.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888412.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0383"/>
    <dbReference type="EnsemblBacteria" id="CCC77898">
        <property type="protein sequence ID" value="CCC77898"/>
        <property type="gene ID" value="lp_0383"/>
    </dbReference>
    <dbReference type="GeneID" id="57024197"/>
    <dbReference type="KEGG" id="lpl:lp_0383"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.323"/>
    <dbReference type="HOGENOM" id="CLU_187595_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-320-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7350" checksum="232A8120F31E6517" modified="2011-10-19" version="1">MLVFIVIGLITGVITIGLGYWSYALGKRNKLNLVGSVIPVGNLVITVVYALLFVGGRQRFNKQKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU15</accession>
    <name>F9UU15_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein PlnW,membrane-bound protease CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plnW</name>
        <name evidence="3" type="ordered locus">lp_0429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888449.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0429"/>
    <dbReference type="MEROPS" id="G05.007"/>
    <dbReference type="EnsemblBacteria" id="CCC77935">
        <property type="protein sequence ID" value="CCC77935"/>
        <property type="gene ID" value="lp_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0429"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.349"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079560_5_2_9"/>
    <dbReference type="OMA" id="VWHITES"/>
    <dbReference type="PhylomeDB" id="F9UU15"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-356-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="228" mass="25813" checksum="E5B5DCEA95B4E575" modified="2011-10-19" version="1">MLQKNLRFIGNLLIVSVLSVIIVNISSLPVYIYLITANWFTLLVSFSLYAVIIVFLYNIYKTTAELRQFDFRPWRARLNKRALLLMVIGAVIIVALAFGYAKLTAVWHITESGNERALDLLLRKNPVAMTLDAVIFGPIAEELSFRGFFFSYVLSDQYLDREYQAATIVINGLLFGYLHSGNSLVLLAYYTLFGMVLGTTYLLSKRDIRVNSVAHMLANLGILWLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE4</accession>
    <name>F9UUE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890960.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3478"/>
    <dbReference type="DNASU" id="1063426"/>
    <dbReference type="EnsemblBacteria" id="CCC80446">
        <property type="protein sequence ID" value="CCC80446"/>
        <property type="gene ID" value="lp_3478"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3478"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2894"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120424_0_0_9"/>
    <dbReference type="OMA" id="REWVEWS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2934-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900723">
        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11586">
        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22676" checksum="AE592AE7EB89E9C1" modified="2011-10-19" version="1">MVLNSAREWVDWSCYYFLISWSVLLRCEAIITTIVPFKGIIVSEVMKMKTTATILKEIRQHYQISQAKLAKLLNTSVRTVQHWEQADYQPSGTAVRLIQILATDDAVYTALTNLEEENTIMYLEHDDQKFTIMGVQFRNQEEYRATMNAIISNMYEGFEPTKEDVQDARRFYDEGPISAQEMLARIRTSTNRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG4</accession>
    <name>F9UUG4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroD3</name>
        <name evidence="4" type="synonym">aroE</name>
        <name evidence="7" type="ordered locus">lp_3498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102190.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890980.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3498"/>
    <dbReference type="EnsemblBacteria" id="CCC80466">
        <property type="protein sequence ID" value="CCC80466"/>
        <property type="gene ID" value="lp_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3498"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2914"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_4_9"/>
    <dbReference type="OMA" id="HEHEGDA"/>
    <dbReference type="PhylomeDB" id="F9UUG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2954-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="31185" checksum="AD02DF8DF07757A5" modified="2011-10-19" version="1">MEARIDGHTTMLGLFGSPVGHSGSPAMYNYSFEKAGINDAYLAFDIQADEMASALTKMRVLNMRGANVTMPCKKVAAELVDELSPAAELIGAVNTIVNNDGVLVGHNTDGAGYVENLRQHGVDPQGKRLTVLGAGGAATAIAVQMALDGAQAIHIFNPKDSFYQNAELTAQKIMDKVPACQVTVGDINDQEVLTQAIAQSDILANATKAGMAPNVEQTNIKDMTVFRSDLVVTDTVYNPATTKMLADAAEHGSKTIGGKGMLVWQGAAAFKLYTGQEMPVEEVTQRFFSDDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI9</accession>
    <name>F9UUI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbg9</name>
        <name evidence="6" type="ordered locus">lp_3525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642889.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3525"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80491">
        <property type="protein sequence ID" value="CCC80491"/>
        <property type="gene ID" value="lp_3525"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3525"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2939"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="YGGWGSR"/>
    <dbReference type="PhylomeDB" id="F9UUI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2979-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="480" mass="54546" checksum="9DE753F6E5C1FB21" modified="2011-10-19" version="1">MSEFPEGFLWGGATAANQLEGGYQEGGRGLSIADALPGGKDRFKIVSQPDFDWTIDTDKYTYPNHEGIDFYHHYKEDIALFAEMGFKCYRFSIAWSRIFPNGDETQPNEAGLKFYDDVIDECLANNIEPVITISHYELPLNLAKRYGGWKNRYLIEFYETFARTILTRYASKVKYWMTFNEINSAAHFPVMGQGLVPSTGANDKKNVFQAWHNQFVASAKAVKIAHELRDDIQVGCMILYATSYAYDSNPVNQLANLQHNQDFNFFCADVQVRGAYPTYTKRLLAEYNLTFDDLETTDGDLALLQQYPVDYIGFSYYMSSAVETTGSVTDTVAGNLMGGVKNPFLKASDWGWQIDPTGLRIALNELYDRYQKPLFVVENGLGAIDKPDKNFYVEDDYRIDYLKQHIEAMAGAIDDGVDLMGYTPWGCIDLVSASTGEMSKRYGFIYVDLDDQGHGTLARYPKKSFYWYQDVIKHNGLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK5</accession>
    <name>F9UUK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional protein: transcription regulator PTS system, mannitol(Cryptic)-specific EIIA component</fullName>
            <ecNumber evidence="7">3.1.3.18</ecNumber>
            <ecNumber evidence="7">3.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="7"/>
    <dbReference type="EC" id="3.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3543"/>
    <dbReference type="EnsemblBacteria" id="CCC80507">
        <property type="protein sequence ID" value="CCC80507"/>
        <property type="gene ID" value="lp_3543"/>
    </dbReference>
    <dbReference type="GeneID" id="57026743"/>
    <dbReference type="KEGG" id="lpl:lp_3543"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2954"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_1_0_9"/>
    <dbReference type="OMA" id="GYYFDCH"/>
    <dbReference type="PhylomeDB" id="F9UUK5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2995-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="283"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="394"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="540"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="683" mass="78264" checksum="5C15D41FCCD27BC3" modified="2011-10-19" version="1">MRVNFSKRKHGNELLEILLTSSGYTTANFLQQHLHISRRSLFYLINKVNDELDQHAEFPITNVKKLGYYLPTDTIKFLHKMTEKETSSKIMTNNAKQRQLLIAFSILNTSGCSLADLTYQFNISKNTVIRDIKVLHSQLALYHLQITNTESGKIITGSPTAVRKWVYDHATQLKTLIEQTRRATIKPTTINDQIKLFERITGKYLTDDASITIRLFLYWYLTNIRDCNNQLSDVISAQTDLTLDHIWAKSFLNDYHIDNSNEVDYLVKLINSSQFAHVNWNDDLIQKLKPFSVRMISSFNHLSGAHVSIKSISDSLTVHLLSTYYRAQYNMPFEYPDLKSIQQHYHHTFEITRKVVVPFEQYIHHTLSDDEIALIAIYFGGAIREQKTSTPTQNEVLVVCSSGIGTSRLLLQQLESRYRGIHFSSPMNVLQYENSDLSNVQLVISTIKLNTQRNIPITTVSAFPSELEWKIIDNAIIKAGLATSDTLKLFNVDTLLDIVGNYAMIRNPMGLKLALNDYLTQLTQEPLLAAPQENLSELIKLLPPEHVGFLNHQKSWKQAVRTALSPLLEDYSVEKNYIDQIIHLTESNGPYMVIGSGVMLAHAAPRDGVNNLGATFFLLDKPLPVMTNQKMVHVIIGLAPIDYEKHLSFISDLMTQLQQKDWLTNLYHLNNKRDLFRYLYKDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RZ3</accession>
    <accession>F9ULK5</accession>
    <name>RBSU_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Putative ribose uptake protein RbsU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rbsU</name>
        <name type="ordered locus">lp_3658</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in the uptake of ribose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641602.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891126.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RZ3"/>
    <dbReference type="STRING" id="220668.lp_3658"/>
    <dbReference type="EnsemblBacteria" id="CCC80612">
        <property type="protein sequence ID" value="CCC80612"/>
        <property type="gene ID" value="lp_3658"/>
    </dbReference>
    <dbReference type="GeneID" id="57026838"/>
    <dbReference type="GeneID" id="66451085"/>
    <dbReference type="KEGG" id="lpl:lp_3658"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3056"/>
    <dbReference type="eggNOG" id="COG4975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076024_0_1_9"/>
    <dbReference type="OMA" id="GWACAQI"/>
    <dbReference type="PhylomeDB" id="Q88RZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3099-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213635" description="Putative ribose uptake protein RbsU">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="294" mass="31049" checksum="34F63D5E4AEB5C49" modified="2003-06-01" version="1">MNTTALLIGLGPLLGWGLYPTIASKIGGRPVNQILGSTIGTLIFALIYAWVQGIAFPSGMNLWFSILSGIGWASAQIVTFKVFTMVGSSRAMPITTAFQLLGASLWGVFALGDWPGAMDKVLGGLALVGIIIGAWLTVWSEHKDAGNARTLRQAVIWLAVGEIGYWAYSAAPQATNIGGEEAFVPQAIGMVIVSIVYALFLASRGEKLALVEGVSYTHIISGFFFAFAALTYLISAQPNMNGLATGFILSQTSVVLATLTGIWFLGQKKTTKEMWVTIGGLILIIAAAAVTVTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-10" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SI6</accession>
    <accession>F9UUA9</accession>
    <name>MENG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menG</name>
        <name type="ordered locus">lp_3431</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102162.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SI6"/>
    <dbReference type="SMR" id="Q88SI6"/>
    <dbReference type="STRING" id="220668.lp_3431"/>
    <dbReference type="EnsemblBacteria" id="CCC80411">
        <property type="protein sequence ID" value="CCC80411"/>
        <property type="gene ID" value="lp_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3431"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2859"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_9"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="PhylomeDB" id="Q88SI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2899-MON"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000193285" description="Demethylmenaquinone methyltransferase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <sequence length="237" mass="27150" checksum="D6AB051C01794035" modified="2003-06-01" version="1">MANRYLHNVQGLFDTIAPNYDRMNNIISLGTHRHWRKQTMAQIHLASNAHVLDLCCGTGDWTIALAKELQAPGEVIGLDFSAPMLKLAQQKVTQQQVADRVWLRRGNAMHLPFKDNTFDLVTIGFGLRNLPDKAQALTEIYRVLKPGARLVCLETSQPDQPLIKPVWQWYFTKVVPLFGRLFAHQYQEYSYLQETTRHFASYQQLATMFQQAGFQNVHFQRFNFGAAAAHFGTKEAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88TV5</accession>
    <accession>F9URS1</accession>
    <name>SYY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">lp_2807</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642093.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88TV5"/>
    <dbReference type="SMR" id="Q88TV5"/>
    <dbReference type="STRING" id="220668.lp_2807"/>
    <dbReference type="EnsemblBacteria" id="CCC79910">
        <property type="protein sequence ID" value="CCC79910"/>
        <property type="gene ID" value="lp_2807"/>
    </dbReference>
    <dbReference type="GeneID" id="57026175"/>
    <dbReference type="KEGG" id="lpl:lp_2807"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2350"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_9"/>
    <dbReference type="OMA" id="YHSSVQA"/>
    <dbReference type="PhylomeDB" id="Q88TV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2406-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000234718" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="418" mass="47076" checksum="B4A3068C8EB86588" modified="2003-06-01" version="1">MNIIDDLKWRGAINQQTDEAGLKELTENQSVSLYCGIDPTGDSMHIGHLIPFMILKRFQLAGHHPYVVVGGGTGAIGDPSGKNSERKLQTMDQVKHNQDGLSAQMYKLFGHDENFSIVNNYDWLSKISLLDFLRDYGKLFSVNTMLNKEVVASRLEVGISYTEFTYQILQSVDFLHLYRAEHVQLQIGGADQWGNITAGTDLIHRLEGNDAKAYGLTIPLLLKADGTKFGKTAGGAVWLNPERTSPYEFYQFWINQDDRDVVKYLKYFTFLSHEEIDRLAETVKTAPEKREAQRRLAEEVTEFVHGKQAVVEAENITKALFTGDVQSLTADEIEQGFKGVPSADVSAEKQNIVLWLVDATKFEPSRRQAREDIKNGAIRINGEKVTDVEAEIDPSAAFNGKFVIVRRGKKRYFLAHVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V03</accession>
    <accession>F9UQK3</accession>
    <name>RUVB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">lp_2286</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V03"/>
    <dbReference type="SMR" id="Q88V03"/>
    <dbReference type="STRING" id="220668.lp_2286"/>
    <dbReference type="EnsemblBacteria" id="CCC79492">
        <property type="protein sequence ID" value="CCC79492"/>
        <property type="gene ID" value="lp_2286"/>
    </dbReference>
    <dbReference type="GeneID" id="57025828"/>
    <dbReference type="GeneID" id="66450040"/>
    <dbReference type="KEGG" id="lpl:lp_2286"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1934"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_9"/>
    <dbReference type="PhylomeDB" id="Q88V03"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1976-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000165544" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="336" mass="37370" checksum="A9493803E375905D" modified="2011-11-16" version="2">MDDDKLLSGDKADDEEASLEKSLRPQTLAQYIGQARVKHELGVYIEAARKREESLDHVLLYGPPGLGKTTLAMVIANEMQVNIRTTSGPAIEKPGDLVALLNELEPGDILFIDEIHRLPKIVEEMLYSAMEDFFVDIVVGQGPTAHPVHFPLPPFTLIGATTRAGMLSAPLRDRFGIVEHMAYYEVADLEDIVKRTADIFQTSIKPSGAHEIARRSRGTPRIANRLFKRIRDFAEVADQDAIDEAIVARSLTYLRVDDAGLDETDNKLLRTMLEYYDGGPVGLATIAANIGEETDTIAEVVEPYLLQIGFLKRTQRGRVVTIKGYQHLGFPYPENK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V10</accession>
    <accession>F9UQJ6</accession>
    <name>SYA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Alanine--tRNA ligase</fullName>
            <ecNumber>6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alanyl-tRNA synthetase</fullName>
            <shortName>AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alaS</name>
        <name type="ordered locus">lp_2277</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101703.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889999.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V10"/>
    <dbReference type="SMR" id="Q88V10"/>
    <dbReference type="STRING" id="220668.lp_2277"/>
    <dbReference type="EnsemblBacteria" id="CCC79485">
        <property type="protein sequence ID" value="CCC79485"/>
        <property type="gene ID" value="lp_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2277"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1927"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_9"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="PhylomeDB" id="Q88V10"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1969-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000075130" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="880" mass="97266" checksum="BB5217FEA3988508" modified="2003-06-01" version="1">MKKLSSSEIRQMYLDFFHEKGHTIVPSASLVPVDDPTLLWINSGVATMKKYFDGSVVPDNPRMTSSQKSIRTNDIENVGRTARHHTLFEMLGNFSVGDYFKKEAISWAWELLTSPKWFGWDPDKLYMTVYPKDTDAAKFWEATGVKPDHIIKVEDNFWDIGQGPSGPDSEIFYDRGEAFNNLADDDPENYPGGENERYLEVWNIVFSQFNHTPEGTYEPLPRKNIDTGMGLERVVSVFQNAKTNFETDLFLPIIHKTEELSDGKHYGDNAQDDVSFKVIADHARAITFAISDGALPSNEGRGYVIRRLIRRAILHGQKLGLKEAFLDQLVPIVGKIMASHYPDVLKNSAYIEKIVASEESRFNETLNDGLNLLNNLIAETKQTGHDTLAGKDAFKLYDTYGFPFELTKEYAGDEDLDVDEAGFEVEMKAQRDRARNARSSAKSMGVQRSLLIDIKTPSEYVGYDELTNVQGTLNDIIVDETLVDHVDSGQAEMIFSKTPFYAEMGGQVADRGVILDDAGEMVAKVTDVQNAPNKQHLHTVEVLKPMRKDATYTLNVDLAFHNKVEKNHTATHLLDQALRDVLGEHTKQAGSLVEPDYLRFDFTHFGQVTDEELAKVEQIVNDKIWAALPVSAIQTDQETGHKMGAIAVFTEKYGKIVRVVSIGDYSIEFDGGTHVKNSSELGLFKIVSETGIGAGTRRIEAVTSKEAFELLAGEEQTLKQVAAQVKAPKLADTPAKVSQLQADLKAEQQNRASLESRLAKQQAGAVFDQVDDVNGTTLIAQQIEVSGMDQLRQLADTWKTKQYSDVLVLGTVIGEKVNLLVAVSDDKVKAGIKAGDLIKAIAPKVGGGGGGRPTLAQAGGKKPAGLPVALKAAHEWLAEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VQ8</accession>
    <accession>F9UPU4</accession>
    <name>SYD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">lp_1980</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101612.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889747.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VQ8"/>
    <dbReference type="SMR" id="Q88VQ8"/>
    <dbReference type="STRING" id="220668.lp_1980"/>
    <dbReference type="EnsemblBacteria" id="CCC79233">
        <property type="protein sequence ID" value="CCC79233"/>
        <property type="gene ID" value="lp_1980"/>
    </dbReference>
    <dbReference type="GeneID" id="57025558"/>
    <dbReference type="KEGG" id="lpl:lp_1980"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1673"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_9"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="PhylomeDB" id="Q88VQ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1697-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110888" description="Aspartate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="538"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="598" mass="67603" checksum="971B6CDBD645DD6D" modified="2003-06-01" version="1">MKRTTYAGLINEDYLGQTVTLQGWVQKRRDLGSLIFIDLRDREGIVQLVFSQEFSADALAVADQLRGEYVIEVQGTVVNRNADAVNDRMKTGKVEVEIHDAKILNKAKTPPFYIQDDINVSDELRLKYRYLDLRRPEMQRGLKIRNGITQAVHSYFDANGFYDIETPFLTKSTPEGARDYLVPSRVYQGHFYALPQSPQLFKQLLMGAGFDRYYQIARCFRDEDLRGDRQPEFTQIDMETSFLTAEEIQSYTEGLIKQVMKDVKGVDIKTPFTRMTWQEAMDRFGSEKPDVRFGMELKDMGVAVSNAGFKVFDNALANGGLVKAIAVPGGADQYSRKQIDAYTEYVKRFGAKGLAWMKVTDDGFSGPVAKFFKNDGDFEAITSAAAAKPGDLLLFAADSFKVVSDTLGYLRTAIAKELDLIDQDQYAYLWVVDWPLFEYDEGIERWVPAHHPFTMPNEEDVHYLNDGEDPHKAHAQSYDIILNGYELGGGSIRIHTRELQEKMFKALDFTKERAQEQFGFLLDALDMGFPPHGGLAIGLDRFAMLLSGNDNIREVIAFPKNSKASEPMTNAPSRVSDQQLADLDLNITNPVTDDEPTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WG9</accession>
    <accession>F9UP34</accession>
    <name>FABZ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="1">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name type="synonym">fabZ1</name>
        <name type="ordered locus">lp_1670</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640408.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889487.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WG9"/>
    <dbReference type="SMR" id="Q88WG9"/>
    <dbReference type="STRING" id="220668.lp_1670"/>
    <dbReference type="EnsemblBacteria" id="CCC78973">
        <property type="protein sequence ID" value="CCC78973"/>
        <property type="gene ID" value="lp_1670"/>
    </dbReference>
    <dbReference type="GeneID" id="57025244"/>
    <dbReference type="GeneID" id="66449541"/>
    <dbReference type="KEGG" id="lpl:lp_1670"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1409"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_1_9"/>
    <dbReference type="OMA" id="VMALIPN"/>
    <dbReference type="PhylomeDB" id="Q88WG9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1436-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091693" description="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <sequence length="147" mass="15998" checksum="0CAA97F65C3E59EC" modified="2003-06-01" version="1">MSVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGVLIIEALAQAASILILKSEKFAGKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGTVSCQAMVGDKAACTTDLTFIVGATDSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WU6</accession>
    <accession>F9UNQ4</accession>
    <name>RL20_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name type="ordered locus">lp_1517</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640279.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889357.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WU6"/>
    <dbReference type="SMR" id="Q88WU6"/>
    <dbReference type="STRING" id="220668.lp_1517"/>
    <dbReference type="EnsemblBacteria" id="CCC78843">
        <property type="protein sequence ID" value="CCC78843"/>
        <property type="gene ID" value="lp_1517"/>
    </dbReference>
    <dbReference type="GeneID" id="57025114"/>
    <dbReference type="GeneID" id="66449403"/>
    <dbReference type="KEGG" id="lpl:lp_1517"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1277"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_9"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="PhylomeDB" id="Q88WU6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1304-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000177170" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="118" mass="13590" checksum="FE03041154021CD5" modified="2003-06-06" version="1">MARVKGGTVTRKRRKRILKLAKGYRGAKHIQFKVAKDQVMKSYLYAFRDRRRRKSDFRRLWIARINAAARINDISYSQLMHGLKLANVDVNRKMLADLAVNDADAFKALVDTAKKALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WU9</accession>
    <accession>F9UNQ1</accession>
    <name>SYT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">lp_1514</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WU9"/>
    <dbReference type="SMR" id="Q88WU9"/>
    <dbReference type="STRING" id="220668.lp_1514"/>
    <dbReference type="EnsemblBacteria" id="CCC78840">
        <property type="protein sequence ID" value="CCC78840"/>
        <property type="gene ID" value="lp_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="57025111"/>
    <dbReference type="KEGG" id="lpl:lp_1514"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1274"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_9"/>
    <dbReference type="PhylomeDB" id="Q88WU9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1301-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000100995" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="248"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01228"/>
        </source>
    </evidence>
    <sequence length="654" mass="73819" checksum="F2000A2C442168CD" modified="2011-11-16" version="2">MASINVKFPDGAEKQFDAGVTTEAIAKSISPSLAKRSVAGKFNDQIVDYRQPLTTDGSIEIIAADSEDGLNVLRQTAAQVLANAVKQLFPNIHFGSGEGNANGFFFDTDNPDEDGKQVSEDDLEAISDKMAAIIKQDLPIEREVLSKADALALVGDNPYQQDLVNERAAANNDQVVVYKQGDFVDLSDGAQLASTGKVKVFKLLSVAGAYWQGKSSNPMLQRIYGTAFLKQKDLDADLKRRQEARERDHRVIGNELDLFFVDPKVGNGLPYWMPNGATIRRQIERYIIDKEVANGYQHVYTPVLANLDVYKQSGHWDHYREDMFPPMDMGDGEQLELRPMNCPSHIQIYNHHIRSYRELPLRIAELGMMHRYEKSGALTGLSRVREMTLNDGHTFVALDQIEEEFKKILSLMVEVYEDFDISDYRFRLSYRDPENKEKYFDDDAMWERSQKMLKSAMDDMGLDYFEAEGEAAFYGPKLDVQTKTALGGEETLSTIQLDFLLPERFDLKYVGADGEEHRPVMIHRGLVSTMERFVAYLTEIYKGAFPTWLAPKQVTIIPVNNGAHGAYAETVRRRLAAEGVRVSIDDRNEKMGYKIRESQTKKVPYLLVVGDQEVANGSVSVRKYGEERTESEAVDMFIGAITQEIKHYSRGASK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X63</accession>
    <accession>F9UND5</accession>
    <name>METE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metE</name>
        <name type="ordered locus">lp_1375</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101377.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889238.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X63"/>
    <dbReference type="SMR" id="Q88X63"/>
    <dbReference type="STRING" id="220668.lp_1375"/>
    <dbReference type="EnsemblBacteria" id="CCC78724">
        <property type="protein sequence ID" value="CCC78724"/>
        <property type="gene ID" value="lp_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1375"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1155"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_9"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="PhylomeDB" id="Q88X63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1184-MON"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000098635" description="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <sequence length="768" mass="86433" checksum="477E4CE0C87ECE24" modified="2003-06-01" version="1">MTIINSNLGYPRLGEHREWKHLLEHFWKGQLDNVTFHATAKKLRLANLKKQRDLGVDYIPVADNSDYDHVLDTLVAFNAIPSRFGHFDHQLDLPDYYAIARGTDTAVAAEMTKWFNINYHYIVPEFDDVSFKLLDNRWLRYYQEAKQELGIDGKPVILGPISFLKLGKRHGQYLDDAAVNELLPQLLPLYQQVFEELATAGAKWIQLDEPTLVKTTTVAELAPYQTALEHLHAAVPSLKIELQTYFDSLDQYDKIVTWPIQALGLDLVHDHGENLAHLVDHGFPTDKILAAGIIDGHNVWASDLQAKLALVQQLRQIVTDDQLWLQPANSLLHVPITTKNETKADPVLLGGLAFADQKLAELHTLTVAANQGVAAVQAVFDHNQANLTALNQSSHRNNQSVRAAEAQLSNQKFERQAPFATRIKLQHDRLHLPLLPTTTIGSFPQSAQVRAKRAAWRKGNLTDADYQAFLHAETKRWIKLQEDLGLDVLVHGEFERTDMVEYFGQKLTGFYATQNGWVQSYGSRGVRPPVIFGDVAYTEPITVAESVYAQSLTDQPVKGMLTAPLTIINWSFVRDDIPRAQVQNQIALALRQEVQNLEKAGIKIIQVDEPALREGLPLKQRHWQAYLDEAVYSFKITTTGVQNDTQIHTHMCYSNFADIINTIKALDADVISIETSRSHGEIISAFEQTGYDQEIGLGVYDIHSPRVPSVAEIEANIQRALRVIDARQFWINPDCGLKTRQESETLAALKNMIAARNAIQAQLTTSIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XQ0</accession>
    <accession>F9UMU6</accession>
    <name>DNLJ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">lp_1145</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XQ0"/>
    <dbReference type="SMR" id="Q88XQ0"/>
    <dbReference type="STRING" id="220668.lp_1145"/>
    <dbReference type="EnsemblBacteria" id="CCC78535">
        <property type="protein sequence ID" value="CCC78535"/>
        <property type="gene ID" value="lp_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1145"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.966"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_9"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="PhylomeDB" id="Q88XQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-977-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313278" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="597"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="679" mass="74522" checksum="68529A7D46381C58" modified="2003-06-01" version="1">MADKPNTMTVEQAADEAAALRQTLNEWRRQYYDEDAPNVEDSVYDQKYERLVELEQTFPQLVTPDSPTQLVGGTVKAGFDKVTHEIPMLSLGDVFSQAELQEFVDRLEQNVGHPVDYNCELKIDGLALSLRYEDGVLVQGSTRGNGTVGEDITANIKTIKSIPQRLTRPLTIDVRGECYMPKAAFAALNERREAAGEPVFANPRNAAAGTLRQLDSRVVAERQLSTFMYNIADYEPLTARTQSDMLTEFADLGFAINPDFKVAHSMADVFSYIDHYQNERPELAYGIDGIVIKANPLPLQRSLGATVKVPRWAIAFKFPPDEQPTLLKDVEWTVGRTGVVTPTAVMEPVQLAGTTVARASLHNPDYVAAKDVRIGDTVLLHKAGDIIPEISSVDLAKRPKDAQPLVIPTTCPSCGAPLVHLEDEVALRCINPKCPAQVQEGLVHFASRNAMNIDGLGPRIIAQLYANRLVSDVAGLYRLTKAQLLTLDKIKDKSAEKLLTAIDRSRDNSLERLLFGLGIRHVGAKVARLIAQHFGTIEALMAASQEEIAAIDSMGDVIANAVVQYFESDEVHTLIRELQAVNVNTTYQGPSATVAEDSNSWFAGKRVVLTGKLESFTRPDATQWLQAHGATVMGSVSKKTDLVIAGSDAGSKLQKAQQLDITVWDEARFSETMREDAQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XZ7</accession>
    <accession>F9UMJ4</accession>
    <name>SYS2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase 2</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase 2</fullName>
            <shortName evidence="1">SerRS 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS2</name>
        <name type="ordered locus">lp_1012</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XZ7"/>
    <dbReference type="SMR" id="Q88XZ7"/>
    <dbReference type="STRING" id="220668.lp_1012"/>
    <dbReference type="EnsemblBacteria" id="CCC78433">
        <property type="protein sequence ID" value="CCC78433"/>
        <property type="gene ID" value="lp_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="57024673"/>
    <dbReference type="GeneID" id="66448927"/>
    <dbReference type="KEGG" id="lpl:lp_1012"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.858"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_9"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="PhylomeDB" id="Q88XZ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-869-MON"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122066" description="Serine--tRNA ligase 2">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="425" mass="48136" checksum="2F44FE6016E5CEF6" modified="2003-06-01" version="1">MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEISQKKRNKEDASAEIAEMQKVSADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEEDAVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSGSRFLYYVGDGAKLERAVYNFFLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYRDEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEKLTNNAESLLKKLGLPYHVITLTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQARRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQNEDGTVTIPDVLVPYMHGKTKIEKQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z39</accession>
    <accession>F9UL12</accession>
    <name>PTH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">lp_0538</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888541.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z39"/>
    <dbReference type="SMR" id="Q88Z39"/>
    <dbReference type="STRING" id="220668.lp_0538"/>
    <dbReference type="EnsemblBacteria" id="CCC78027">
        <property type="protein sequence ID" value="CCC78027"/>
        <property type="gene ID" value="lp_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0538"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.445"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_9"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="PhylomeDB" id="Q88Z39"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-448-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187755" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="185" mass="20293" checksum="7B6F83767A9A2529" modified="2003-06-01" version="1">MKMIVGLGNIGRQYAQTRHNVGFMIVDELASKLNVTFQTSKFEAQVATAFQDGEKILLVKPATYMNDSGRAVGPLMSYYNVDPADLLVIHDDLDLPLGKVRLKQKGSAGGHNGIKSIISHVGDQHFKRVKVGIDHPQKMSVVDYVLGKFTPAEVAKFDDAKITALAAVEAWLANDDFTAVMNQYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z76</accession>
    <accession>F9UKW3</accession>
    <name>PYRG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">lp_0481</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888492.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z76"/>
    <dbReference type="SMR" id="Q88Z76"/>
    <dbReference type="STRING" id="220668.lp_0481"/>
    <dbReference type="PRIDE" id="Q88Z76"/>
    <dbReference type="EnsemblBacteria" id="CCC77978">
        <property type="protein sequence ID" value="CCC77978"/>
        <property type="gene ID" value="lp_0481"/>
    </dbReference>
    <dbReference type="GeneID" id="57024276"/>
    <dbReference type="GeneID" id="66448551"/>
    <dbReference type="KEGG" id="lpl:lp_0481"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.395"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_9"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="PhylomeDB" id="Q88Z76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-399-MON"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138193" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="537" mass="59736" checksum="27EC5AA85607A3FF" modified="2003-06-01" version="1">MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGTETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLQKERRGDYLGATVQVIPHITNAIKEKIMRAGTTTDSDIVITEIGGTVGDIESLPFIEALRQMKSDLGSDNVFYIHTTLIPYLRAAGEMKTKPTQHSVKELRSYGIQPNMLVVRTEQPITREMRNKIASFCDVEPEAVIESLDVKTIYSIPLNVQKQNMDQIVLDHFDVQAPKADMSEWIDLEHHVQNLSRTIKIALVGKYVALQDAYISVTEALKHAGYTDDADIDLKKISAEDVTPENVEELLGDADGILVPGGFGDRGIEGKITAIKYARENDVPFLGICLGMQMASVEFARNVLGLKDANSAEIDPKTPDNIIDLMADQEDVEDMGGTQRLGAYPCKLKPGTVAAKAYHNEEVVMERHRHRYEFNNKYREAMAAKGMVFSGTSPDNRLVEVIELPKKRFFVASQYHPEFLSRPNRPEGLFKAFIDAANQTGKVKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZS1</accession>
    <accession>F9UT35</accession>
    <name>MTLD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtlD</name>
        <name type="ordered locus">lp_0233</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888280.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZS1"/>
    <dbReference type="SMR" id="Q88ZS1"/>
    <dbReference type="STRING" id="220668.lp_0233"/>
    <dbReference type="EnsemblBacteria" id="CCC77766">
        <property type="protein sequence ID" value="CCC77766"/>
        <property type="gene ID" value="lp_0233"/>
    </dbReference>
    <dbReference type="GeneID" id="57027056"/>
    <dbReference type="KEGG" id="lpl:lp_0233"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.194"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036089_2_0_9"/>
    <dbReference type="OMA" id="GKKAVHF"/>
    <dbReference type="PhylomeDB" id="Q88ZS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-188-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000170709" description="Mannitol-1-phosphate 5-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="3"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00196"/>
        </source>
    </evidence>
    <sequence length="385" mass="43200" checksum="1B174ECC6B5D2C8B" modified="2003-06-01" version="1">MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEVHDVKGINNGKDPKAVAEEIAQADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDIIACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVDRIVPLQKHDDPLFVSVEPFKEWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVKDDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRKLGFNERFIRPIRELKERGRDYSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRETTDLKDEDLVNEIKAAYEKHLAAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZZ2</accession>
    <accession>F9USW5</accession>
    <name>Y149_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein lp_0149</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0149</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100903.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZZ2"/>
    <dbReference type="SMR" id="Q88ZZ2"/>
    <dbReference type="STRING" id="220668.lp_0149"/>
    <dbReference type="EnsemblBacteria" id="CCC77696">
        <property type="protein sequence ID" value="CCC77696"/>
        <property type="gene ID" value="lp_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0149"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.120"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_9"/>
    <dbReference type="OMA" id="DPMTRLD"/>
    <dbReference type="PhylomeDB" id="Q88ZZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-118-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022216">
        <property type="entry name" value="ABC_Co_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12558">
        <property type="entry name" value="DUF3744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092024" description="Putative ABC transporter ATP-binding protein lp_0149">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="302"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="335"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="566" mass="62356" checksum="256855F2FF688A91" modified="2003-06-01" version="1">MSAPIISFKNFSFQYNSQTEPTLRDINLDIYPGEKVLIAGPSGSGKSTLGRCLNGLIPQSYPGTVTGQARIAGQTITESSIFALSQDVGTVLQDPDSQFVGLTVVEDMAFSLENDQQTQPAMRQATEQWAQTLDLQDLLTHRPQELSGGQKQRVAMAGVLIDNSKILLFDEPLASLDPASGKASMALIDQLTHTQDLTVIIIEHRIEDVLQQPIDRLIVMQDGAIVANDRPETILRQSLMTQLGLREPLYLSALKLAGVDLATCQHLDNLQALQVPDLTATLQNWTTGVQLQSPTVHDQPLLAIEHLTFGYDPAKPIINDITVTLHQGEMISLVGQNGTGKSTLSNLITGFLMPQSGKMRFNGHSLADQSVKERADQIGYILQDPNQMISTTMIFDEVAAGLVLRGVADDEVKRRVQAVLKVCGLYEFRHWPISALSFGQKKRVTIAAILVLEPAMLILDEPTAGQDLQHYTEMMTFLTKINQEQHMTIMLITHDMHLMLEYTDRTIVLGHGNILMDARPADVLTNASIIQQASLAKTSLYTLAEAHHLNPTEFVAKFVQAEREAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q890J1</accession>
    <accession>F9US49</accession>
    <name>GLGB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="1">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycogen branching enzyme</fullName>
            <shortName evidence="1">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgB</name>
        <name type="ordered locus">lp_0020</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100852.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888110.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890J1"/>
    <dbReference type="SMR" id="Q890J1"/>
    <dbReference type="STRING" id="220668.lp_0020"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77596">
        <property type="protein sequence ID" value="CCC77596"/>
        <property type="gene ID" value="lp_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0020"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.18"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_9"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="PhylomeDB" id="Q890J1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-17-MON"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000188712" description="1,4-alpha-glucan branching enzyme GlgB">
        <location>
            <begin position="1"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <sequence length="634" mass="72981" checksum="485346A5038C47EF" modified="2003-06-01" version="1">MVKQTTEMNDASYLFNTGAGFNSQDYLGCHLAASGRAVFRVWAPHAKAVGVVGDFNDWQPSALKLLGATGIWQGQVPNVHAGQLYKFQITTPTGQVQLKIDPFAQQFERKPGDAAVVVEPMTMRWHDSLWLARRKKSRAANRPINIYEVHLGSWRRHLDGSYYTYAELAAELIPYVKQRGYTHIELMPVMEHLLDASWGYQQLGYFAPTSRFGKRDSFLSFVDQCHQANIGVFVDWVPGHFIRNYDALYQYDGTPTFEYADPERANNRRWGAWNFDLGKTQVQSFLISSAEYWLDQCHLDGLRVDAVSNMLYCDYDEGREGQVNQYGDNRNLEGIAFLQKLNTTVLTHHPDILMIAEESSAYPQVTGSVANGGLGFNYKWNMGWMHDTLDFFMMDPLYRHDHFNLLTFAFVYMFDERFILPFSHDEVVHGKKSLMHKMSGDRYNQFANLRTMLTYMAAFPGKQLNFMGSEWGQFLEWRDWSALEWVDLKDDLNHRMQQFTTQLNAVYRHNRPLWEQDHDPAGIIYTHTDDPDSSTMGFIRQAKRKYSFVVAAFNFVPVERQDYRIGVPYRGRYELLLNTEAQAFGGTWTKLETTFTAVDKPYRGQPASFTVTLPAMGALLIRPVKVIGGVKHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW4</accession>
    <name>F9UKW4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional activator, Rgg/GadR/MutR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888493.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UKW4"/>
    <dbReference type="STRING" id="220668.lp_0482"/>
    <dbReference type="DNASU" id="1061440"/>
    <dbReference type="EnsemblBacteria" id="CCC77979">
        <property type="protein sequence ID" value="CCC77979"/>
        <property type="gene ID" value="lp_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0482"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.396"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072045_1_1_9"/>
    <dbReference type="OMA" id="LILGNCC"/>
    <dbReference type="PhylomeDB" id="F9UKW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-400-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010057">
        <property type="entry name" value="Transcription_activator_MutR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01716">
        <property type="entry name" value="RGG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="34252" checksum="DE9CF7FB1B9374F1" modified="2011-10-19" version="1">MTHGQLIRKLRKERGLTQAQLAEGISSRTTLSTLENSKTDVNINTLFSYLDRLNVSIQEYMFYFNDSSNTEKELATKYFYDNIVKKRDIEIEQRILDYQSKYKDSKDFYYCCLSIELKLFLNKKKDKTVFDVREDTEIIKKYLERVTQWGHFEMSIFANCLYIFTSDYIRATFTILLKRTKILSKIDTYQNDISIFLNNCIVLALERKNYQNARFYIQQLYQISEKTPRKAYDRMMCAYYLALLKQLKGVNANVDSTISHFKELGFSEHAEMLENLRDRLLSSSKQSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ4</accession>
    <name>F9UKZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888523.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0517"/>
    <dbReference type="EnsemblBacteria" id="CCC78009">
        <property type="protein sequence ID" value="CCC78009"/>
        <property type="gene ID" value="lp_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0517"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.426"/>
    <dbReference type="eggNOG" id="ENOG5030E1E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092764_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-430-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="259" mass="29944" checksum="956103A702E2E9BD" modified="2011-10-19" version="1">MQRKYIYANLEKLDNLVFAYGIDQSDFVHGIKRLPANLVSLVGVDDNEHAVNAHTGLNVINDENEIRRYLLQSHALPVKWLDYDEVGDLDFLTATEIAELLYLGHMDRPIRSPFNYKLRNHYVFLEQRNGGIKVYFYYISAFSHILSAAIVRHTLAAYRGRRMFMRSLSVPRVPEAILKQLVQLMPDGLFIYFDQSMVRQRQLLVPVHTETTGNEIEVFDPARGGENRRTHHVATLTFNLNSGVWDLQVQDQAAFEEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL50</accession>
    <name>F9UL50_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="2">3.6.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888579.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0580"/>
    <dbReference type="DNASU" id="1061533"/>
    <dbReference type="EnsemblBacteria" id="CCC78065">
        <property type="protein sequence ID" value="CCC78065"/>
        <property type="gene ID" value="lp_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0580"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.483"/>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841422_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-496-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="330" mass="37648" checksum="EA425E5409B9220A" modified="2011-10-19" version="1">MKWRGYLTPVTENYLHAYGVGYISYVLARKFHVDSVKAFVTGTLHDLGGAVPADERVTVAESIGISLNDEEREVPLLVHAKLGKYFAQTLFDITDEDMLNAILFHTTCIDRASDLVKIVFLADKIRWDRNGTPPYLDGLLAALEISLDDGCSYFLKWLWNSDLYIVHPYLSRSYGAYVRQQQYNPISLQDFSVLQGNLNENLVKKYYLHDIYQEFHRTFYHAHLASVLASKHSVNTEEAYVTSALVNMTNTIKDDELETIASVLNLNVQVPIRPQLTSILARDEYGITSLEMLKTLKSFPQIPSNHNSLLWVVVMSWICQKSIKCEVEDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL76</accession>
    <name>MRNC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mini-ribonuclease 3</fullName>
            <shortName evidence="1">Mini-3</shortName>
            <shortName evidence="1">Mini-RNase 3</shortName>
            <ecNumber evidence="1">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mini-RNase III</fullName>
            <shortName evidence="1">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mrnC</name>
        <name type="ordered locus">lp_0611</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640934.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888605.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UL76"/>
    <dbReference type="SMR" id="F9UL76"/>
    <dbReference type="STRING" id="220668.lp_0611"/>
    <dbReference type="EnsemblBacteria" id="CCC78091">
        <property type="protein sequence ID" value="CCC78091"/>
        <property type="gene ID" value="lp_0611"/>
    </dbReference>
    <dbReference type="GeneID" id="57024386"/>
    <dbReference type="KEGG" id="lpl:lp_0611"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.511"/>
    <dbReference type="eggNOG" id="COG1939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091169_2_0_9"/>
    <dbReference type="OMA" id="AYMGDAI"/>
    <dbReference type="PhylomeDB" id="F9UL76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-522-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000415988" description="Mini-ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <sequence length="136" mass="15318" checksum="F7813288A7922DB3" modified="2011-10-19" version="1">MQVDYQQLNGIALAYLGDAVYEPFIRQHLIESGFTKATKLHHHATHYVSAKAQAALIERMQAEEVLTPTEVDVFKRGRNAKSHTSAKHTDVVTYRISTGFEAVFGYLQLTQQADRIAELAQWCIKQVDEGRVSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI0</accession>
    <name>F9ULI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase (Promiscuous)</fullName>
            <ecNumber evidence="6">3.2.1.114</ecNumber>
            <ecNumber evidence="6">3.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.114" evidence="6"/>
    <dbReference type="EC" id="3.2.1.24" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3631"/>
    <dbReference type="CAZy" id="GH38">
        <property type="family name" value="Glycoside Hydrolase Family 38"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80587">
        <property type="protein sequence ID" value="CCC80587"/>
        <property type="gene ID" value="lp_3631"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3631"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3031"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_2_1_9"/>
    <dbReference type="OMA" id="VVTRPNK"/>
    <dbReference type="PhylomeDB" id="F9ULI0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3074-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041509">
        <property type="entry name" value="GH38_beta-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18438">
        <property type="entry name" value="Glyco_hydro_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="296"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="899" mass="101855" checksum="4A5C9CBA91D10959" modified="2011-10-19" version="1">MTKKKVFVISHSHWDREWYMPFEQHHMRLVTLIDNLLDVFKNDSDFDSFHLDGQMIALDDYLAVRPERKPELAAAIKAGKLRIGPFYILQDDFLISPESNVRNMIIGRDQAREYGQEVPLGYFPDTFGNMGQTPQMMTLANLKTAAFGRGVTPTGFNNQVGDADYASQYSEMWWQGPDGTRILGLLFANWYSNGNEIPVERTAAKKFWDQKLADAEKFASTDNLLMMNGVDHQPVQLDVTAAIKVANELYPDYEFIHSNFTDYLATLSADLPKDLSTIHGELTSQETDGWYTLANTASSRVYLKQENTKNERLLENQAEPLAAMAYPAADYPHDRLRYAWKLLLQNHPHDSICGCSVDEVHREMLTRFAKSQEVARFVAHDALTTLTAKINTTDFNEQAKPFVVVNTTGFTKTGLTRIVVEWDRIAFSATGTIQEQRHQLEQRLAELPELMVVDAHGQSVPFRLIDQQVAFHYDLPKDRFRDPFQAIELTIELNVVNMPAFAWRTLALQPATQTLVPNAMVKAQPRLISNEWLKIGVEDDGSLTITNRETNKTYHQMLVFEDTGDMGNEYIYRQTADKRAYYSTDFPMEVRVVHADELGSELELINYLEVPTSADEQLAKETHAIVDITQRTAQRSTQKVPLTITTKIRLNPNSRQIQFESHVNNQAKDHRLRVLFKTALTAETHVADSIYETVTRANRPAKNWQNPTNPQHQQAFACVFNEANGVTVGNLGLNEYEILPADNTIALTMLRCVGEMGDWGYFATPEAQCQGAFTFNYSLELTDGSEAQRIASYQRAQGMQTPFSNQQTWQHTGTLEADDQYLTLATPEFAVTSLKRANNSAGLTVRGYNLSDRQVPLKVTTSLSKQAVNFFEEELPEVTTDTLMPMEIKTLLLTEAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN8</accession>
    <name>F9ULN8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0649"/>
    <dbReference type="EnsemblBacteria" id="CCC78127">
        <property type="protein sequence ID" value="CCC78127"/>
        <property type="gene ID" value="lp_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0649"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.543"/>
    <dbReference type="HOGENOM" id="CLU_3235300_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-560-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="43" mass="4683" checksum="986D70D1B42770B3" modified="2011-10-19" version="1">MDAEIPAWAIQAACEAMGYADESEVAWEGYPLVMAMVESMEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULP1</accession>
    <name>F9ULP1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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            <dbReference type="EMBL" id="CCC78130.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="60" mass="6951" checksum="28FA18A1A6B5C7B4" modified="2011-10-19" version="1">MSDELRWHITIVREIEGLEVQTEFDTPFELKHLLKTMSDYIGDDKPKMVSIKVIGDGDDD</sequence>
</entry>
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    <accession>F9ULP5</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC78134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888648.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0656"/>
    <dbReference type="EnsemblBacteria" id="CCC78134">
        <property type="protein sequence ID" value="CCC78134"/>
        <property type="gene ID" value="lp_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0656"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.549"/>
    <dbReference type="eggNOG" id="ENOG503333C">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121875_2_0_9"/>
    <dbReference type="OMA" id="RIAHEDM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-567-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006524">
        <property type="entry name" value="ArpU-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01637">
        <property type="entry name" value="phage_arpU"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC78134.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="153" mass="17723" checksum="11790AC4797B7DCE" modified="2011-10-19" version="1">MMGEQQVISDEIFPPIDQEKTIKQVRRFLDKKLPQAVRASGHSVADLKSPSMDGIPKSAPAGNSAEDRITRRLYAEQIVRQTIQAMARCDHECQEILDRLYLQGYSDTMCYMDIGYSKTQYFDRWKPLAMLQFAQSYYLEDLNIYQNRTQTGL</sequence>
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        <name evidence="4" type="ordered locus">lp_0705</name>
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        <lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004888693.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0705"/>
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        <property type="protein sequence ID" value="CCC78179"/>
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    <dbReference type="GeneID" id="66448683"/>
    <dbReference type="KEGG" id="lpl:lp_0705"/>
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    <dbReference type="HOGENOM" id="CLU_006229_4_5_9"/>
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    <dbReference type="PhylomeDB" id="F9ULU0"/>
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    </dbReference>
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        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78179.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="339" mass="37186" checksum="8684C699D2BED03C" modified="2011-10-19" version="1">MATTESFAQTLAAKQPRLLAAFKHIIAQNHLAHAYLFAGMEGAGQPELAHWIAQRLFCLHINDGEPDGTCEECVRIANGSHPDIVTVAPEGQRIHVDQVRYLKAEFSKSAVEGNRKLFIINDAEKMTASAANSLLKFIEEPSGNVTALLLTTNKQLMLPTIISRTQVIEFPPLNAQALQQTFEQAGIAPNQAQMLRGLTNSVTQAQALLADDWLPQAAQALWRWFDQAVKGDPRSFVAVQVNLVGLAKDADHQLVMLDLIAALFQDLLQLHFEVATTALTFGQYQKELAGLTAEVSDEQLIAATELALTAKRQLASNISFQNVLEGLTLKLWPIFQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY9</accession>
    <name>F9ULY9_LACPL</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888742.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0763"/>
    <dbReference type="EnsemblBacteria" id="CCC78228">
        <property type="protein sequence ID" value="CCC78228"/>
        <property type="gene ID" value="lp_0763"/>
    </dbReference>
    <dbReference type="GeneID" id="57024469"/>
    <dbReference type="KEGG" id="lpl:lp_0763"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.644"/>
    <dbReference type="eggNOG" id="ENOG5032ZGB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125416_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9ULY9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-663-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021707">
        <property type="entry name" value="DUF3290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11694">
        <property type="entry name" value="DUF3290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="150" mass="17334" checksum="DC0FD5D42BEBB1E1" modified="2011-10-19" version="1">MTFYSYNYLVHQNNNHTLVQLAAIGIIILIIAILSWLWYRHKTDLKYRDLFIIMVLLLLLLVGIQFNEWQTIKNSFNQKSQVTQIMQRVAKEKGVRKTAVWSNTSSVSSGMLIKVHDHIYNVTINTDGNSYTLTKATPIQSTINYVKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM17</accession>
    <name>F9UM17_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secG</name>
        <name evidence="10" type="ordered locus">lp_0795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888770.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0795"/>
    <dbReference type="EnsemblBacteria" id="CCC78256">
        <property type="protein sequence ID" value="CCC78256"/>
        <property type="gene ID" value="lp_0795"/>
    </dbReference>
    <dbReference type="GeneID" id="57024497"/>
    <dbReference type="GeneID" id="66448759"/>
    <dbReference type="KEGG" id="lpl:lp_0795"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.673"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_6_1_9"/>
    <dbReference type="OMA" id="VTVMMQP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-692-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="78" mass="8526" checksum="529DE98C28A1D148" modified="2011-10-19" version="1">MYNLLLTLILVVSVLIIIAVMMQPSKTNDAMSSLTGGADDLFAKQKPRGFEAFMQKVTVVLGIAFFILALALAWYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM22</accession>
    <name>F9UM22_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polar amino acid ABC transporter, substrate binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888775.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0802"/>
    <dbReference type="EnsemblBacteria" id="CCC78261">
        <property type="protein sequence ID" value="CCC78261"/>
        <property type="gene ID" value="lp_0802"/>
    </dbReference>
    <dbReference type="GeneID" id="57024502"/>
    <dbReference type="GeneID" id="66448764"/>
    <dbReference type="KEGG" id="lpl:lp_0802"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.678"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_20_3_9"/>
    <dbReference type="OMA" id="WVEKRTR"/>
    <dbReference type="PhylomeDB" id="F9UM22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-697-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388976" evidence="8">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="279"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="478" mass="52271" checksum="80A3641F6FE9F3DB" modified="2011-10-19" version="1">MRKWQVAVVMLLAALGSWFAIGTQAQAKTYTIATDTTFAPFEFQVKGGKYKGIDIDILKAIAKKENFNYKLKALSFGAAVQQLSANQVDGVIAGMNITAERKQTFDFSDAYYTSGVVMAVAKDSKVKTFKDLKGKTVALKTGTAGATYAKSIQSKYGFKIKYFNDSNNMYNDVKVGNSAACFEDYPVMSYGIKNGIALKIVSKQHEAGDYGFAVKKGKNAELLKKFNAGLKAIKADGTYKKIINKYLKSSEASLTGEDASSRTFIGLFTQNLDTIGSGLWMTLELTVISIILATILGLILGVLGVMPGKLGPAISSTIIYIFRGMPLMVLAFFIYIGFPDLIGHGFKIPAFVAGMITLMLNEGAYTGAFVKGGFAAVDDGQMEAARSLGLPYWTAMRKVIMPQGIRIMIPSFINQFIITLKDTSILSVIGIVELTQTGTLIIARNFEGFKIWLMIAIIYLIIITLLTWLSNWVQRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM62</accession>
    <name>F9UM62_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888815.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0848"/>
    <dbReference type="EnsemblBacteria" id="CCC78301">
        <property type="protein sequence ID" value="CCC78301"/>
        <property type="gene ID" value="lp_0848"/>
    </dbReference>
    <dbReference type="GeneID" id="57024542"/>
    <dbReference type="KEGG" id="lpl:lp_0848"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.721"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9UM62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-737-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="435" mass="45703" checksum="C58DB2458AE5C5A6" modified="2011-10-19" version="1">MNKIAAYFNFSELKTSMRTEVLAGLTTFVSMAYILFVNPSVLGASGMDKGAVFTATALASALGCLLMGLVAKYPIAIAPGLGVNAFFTYSVVIGMGIKWQTALAGVFVAAVIFILITIFKLREMIIDAIPRDMKLAISAGIGFFIAFIGLHGGGLIVANKSTVVGLGSLTVGTTWLTIFGLIVTLILMSRKVPGGIFIGMVLTSILGLATGLIKMPSTIVSAAPSLKPTFGVALGHIGDINSLQLIIVVLTFLLVTFFDTAGTLVGLAEQAGFMKNNKMPRVGKALMADSTSMLVGSVLGTSPTSAYVESSAGIAVGGRSGMSAVVTGALFILGLFFSPLLNVVTDQVTAPALIIVGVLMAESLKQISWERFEIAVPAFLTVIGMPLTYSISDGIALGFIAYVITMVATKHAKEVHPLMYVLFFIFIIFLWILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM67</accession>
    <name>F9UM67_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">birA2</name>
        <name evidence="2" type="synonym">birA</name>
        <name evidence="4" type="ordered locus">lp_0854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888820.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UM67"/>
    <dbReference type="STRING" id="220668.lp_0854"/>
    <dbReference type="EnsemblBacteria" id="CCC78306">
        <property type="protein sequence ID" value="CCC78306"/>
        <property type="gene ID" value="lp_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="57024547"/>
    <dbReference type="KEGG" id="lpl:lp_0854"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.726"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_1_9"/>
    <dbReference type="OMA" id="WPNDIMS"/>
    <dbReference type="PhylomeDB" id="F9UM67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-742-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="67"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="329" mass="35408" checksum="17B97D9EB043B184" modified="2011-10-19" version="1">MANQVAVLRLLIQAAPAYCSGDWLAQRLAISRTAIWKLVQGLQAAGHTIESRHGRGYRYVANNQLSAPVIEYALTALPPFDLTVLPTVDSTNAYLRRLVTQTPLALPKIVVADTQTAGYGRSGRAFYSPAQTGIYMSIGLPLSDQKALDAGLLTTSTAVVVAQTLQQLFAVDVSLKWVNDVLVNHHKVVGILSEGITSLETGQISAVIIGIGINLTTTAFPALLAHKAGAVVANPNGVTRNQVICELLRRFFNSYGTYRSGTFMDAYRKLSMVIDQQVELKSGTQKYRGVVTDIDAHGALVVKLETGQSRHFSSGEITKVNLLSGGYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME0</accession>
    <name>F9UME0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction-modification system,specificity subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS3</name>
        <name evidence="5" type="ordered locus">lp_0943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0943"/>
    <dbReference type="REBASE" id="7000">
        <property type="entry name" value="S.LplWORF939P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78379">
        <property type="protein sequence ID" value="CCC78379"/>
        <property type="gene ID" value="lp_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0943"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_6_4_9"/>
    <dbReference type="PhylomeDB" id="F9UME0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-815-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="18307" checksum="02ADCB758791758C" modified="2011-10-19" version="1">MKNISLEIGTGKSRFIKFNKSEKYMYKILGSTSIIGYTNHFDYEGDFILTARVGANAGTIYRESGKVKISDNTVFIKASQINFLYYVLTNYNLKRLSFGTGQPLIKSSELNKLKLEVPTNELEQQELGVIFFTIDTLIAANEQVPKLVIKIVNNSLANSSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH7</accession>
    <name>F9UMH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888930.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0990"/>
    <dbReference type="EnsemblBacteria" id="CCC78416">
        <property type="protein sequence ID" value="CCC78416"/>
        <property type="gene ID" value="lp_0990"/>
    </dbReference>
    <dbReference type="GeneID" id="57024656"/>
    <dbReference type="KEGG" id="lpl:lp_0990"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.839"/>
    <dbReference type="eggNOG" id="ENOG5032RPZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096771_0_0_9"/>
    <dbReference type="OMA" id="HDHYGMK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-852-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032083">
        <property type="entry name" value="DUF4811"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16069">
        <property type="entry name" value="DUF4811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="26800" checksum="C243428BC4B8093C" modified="2011-10-19" version="1">MILVLLVVSAIALFLSFIYVHQNTLRISLSVIFAALLVTSIVFVSKNDGQHYGMVKTTTTTTQSLKSAGSSKQLDLLLYQSVGTADKHRVYIYKKTTNQKKVSHTTASVKTANQVKTTTATPKLVTKTTRWTYKSNAMKFWFGLANNDKQLIKRTNYFYINKNWVVLSTTQAKQFSKLMKQQQATLKARAKVYVTNQVKAAMVKNPTMSKAQLAKVQKAAAAQYQANAIQSMLKTVKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS4</accession>
    <name>F9UMS4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malolactic regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mleR2</name>
        <name evidence="3" type="ordered locus">lp_1115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641316.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1115"/>
    <dbReference type="DNASU" id="1063295"/>
    <dbReference type="EnsemblBacteria" id="CCC78513">
        <property type="protein sequence ID" value="CCC78513"/>
        <property type="gene ID" value="lp_1115"/>
    </dbReference>
    <dbReference type="GeneID" id="66449013"/>
    <dbReference type="KEGG" id="lpl:lp_1115"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.943"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="HREIQST"/>
    <dbReference type="PhylomeDB" id="F9UMS4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-956-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="32918" checksum="87D0A69CA59C7772" modified="2011-10-19" version="1">MNTRDLDYFRALVDCQNYTMVAKQFAVSQPAVTQAIHRLEKEFAVKLVIQDRRHQQTNITRAGQLLYKNARQIQASLQLAHREIQSTLQTDIRFGLPPIIGTLYFPQIAEKLLQNGLLQQLKITETGSDELLRKLVHGEINIALLGSYLPFDLPTVRAVHLGARPFSIIVSPQNSLAKQAAVSFKNLGQAQFIGLDGKYVHPQAFRAYCDFAGVHPEVIYRTPDISWVKALVKANLGISLLVRDVVKADDGVVCLEIKDQLPVSFNISVVTRAGYLPTTDEQRFIDQLLKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW7</accession>
    <name>F9UMW7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889070.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78556">
        <property type="protein sequence ID" value="CCC78556"/>
        <property type="gene ID" value="lp_1166"/>
    </dbReference>
    <dbReference type="GeneID" id="57024803"/>
    <dbReference type="GeneID" id="66449058"/>
    <dbReference type="KEGG" id="lpl:lp_1166"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.986"/>
    <dbReference type="eggNOG" id="ENOG50309Q2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1775073_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-999-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16171" checksum="AAF4FD1FCAD2AC9D" modified="2011-10-19" version="1">MNIEILNSAIQDLHFQIVYDRSEDDDNPGQGQFSYTTANPDVKKTFGDDVVQAQLQVTYKEEMFDLSATVFAIVRLSGEMVGIIERQSDNKSIEDDEQEMLNNLNGAIIPALSAKVRAYAALLSTEASNFAIMPADFDDSQPNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ9</accession>
    <name>F9UMZ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Priming glycosyltransferase, polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cps2E</name>
        <name evidence="9" type="ordered locus">lp_1201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101302.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1201"/>
    <dbReference type="DNASU" id="1063103"/>
    <dbReference type="EnsemblBacteria" id="CCC78588">
        <property type="protein sequence ID" value="CCC78588"/>
        <property type="gene ID" value="lp_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1201"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1019"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_2_9"/>
    <dbReference type="OMA" id="GPVFYVQ"/>
    <dbReference type="PhylomeDB" id="F9UMZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1031-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="25650" checksum="E99F0C6AFF9DBC97" modified="2011-10-19" version="1">MKQVEINETVKVGHVQPQTDYRFPTMIGKPVTGWKLFVKRIFDLTVGLIGTILSSPIVLVFAILVKLTSKGPAFYKQERVGLMGKSFNVIKLRSMYQDAEARTGAVWAQKNDPRITPIGRFMRKTRVDELPQFWNVLKGDMSLVGPRPERPVLTEKFSRQFPDFPRRLRIIPGITGYAQINGGYDITPDAKCRLDNYYIEHFSVWFDIKMLLGTVKIIVTGDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN47</accession>
    <name>F9UN47_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643232.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889150.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78636">
        <property type="protein sequence ID" value="CCC78636"/>
        <property type="gene ID" value="lp_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1257"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1066"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062801_0_0_9"/>
    <dbReference type="OMA" id="GNPIWVY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1077-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MucBP" evidence="3">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="3">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="38216" checksum="007464BC96C82033" modified="2011-10-19" version="1">MSFLDRLKGMLQALNSTEAATSATEAPRSIAAQTAAAPTVNQTEALVLVHHLDQDGNELQAADMIAGTIGEEIHLPAVSITGYHLVHIEGLTRWFTTPQASITLTYERQAGQPVWMYAYDIDRRELIGRPTMYRGKLGTPYEVSAPTVAGFKLLRSVGDVTGEYTTTSKTVLFFYRNQNWQQTDLSTGFVQVNKLTAVYPYPGATTTNYLTKLQPGSTYKTYMRVRLVTHETWYAIGDDQWIPETHLQLTTGDTLLLKLPAGYRVQNKRPVRQTGVVSFVPGKQVHTYIEPYGRYLTTVTHGDTVNLIERMADDNGVVWYRLQDQGYLPGRYLTKLDPPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN93</accession>
    <name>F9UN93_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-His dipeptidase</fullName>
            <ecNumber evidence="3">3.4.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepV</name>
        <name evidence="3" type="ordered locus">lp_1321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.13.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889196.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1321"/>
    <dbReference type="EnsemblBacteria" id="CCC78682">
        <property type="protein sequence ID" value="CCC78682"/>
        <property type="gene ID" value="lp_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1321"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1114"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031786_2_0_9"/>
    <dbReference type="OMA" id="GYAGHIE"/>
    <dbReference type="PhylomeDB" id="F9UN93"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1140-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="467" mass="50799" checksum="4E8BBB1281F2686B" modified="2011-10-19" version="1">MSVDWKNEATKHQDDYLADLTTMLRVPSFRDDSQATDDAPLGPGPKQALTTFLAIAERDGFKTKNIDNLVGYAEIGEGDETLAILAHVDEMPAGNGWDTDPFEPTIKDGKMYARGVSDDKGPGMAAYYGLKIVKELGLKLNKKIRFIVGTDEESNWTGMKRYFEVEPAPTLGFSPDAMFPLINGEKGNVSLQLHFGHEDNGDFNLVSFDSGLRENMVPRDAEAVVATDDNEQLAADFTAFLDQQPVTGELTVVPEGVKLEVVGKAAHGMEPRNGINAGTYLATFLTNYAFADDAAAFLDFVANKLHDDSRANQLGLAYKDDVMGDLTMNVGLLSFDHQKGGALTLNFRYPKGIEPADLTAKVQAQLPAGATVTQGDFMVPHYVDPEDPIVKDLMDVYRRQTGDTASQPQIVGGGTYGRMMARGVAFGALFPDTEDTMHQANEFQPIDELMAAMAIYAESIAVLATDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI9</accession>
    <name>F9UNI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscD family,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101410.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889292.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1447"/>
    <dbReference type="EnsemblBacteria" id="CCC78778">
        <property type="protein sequence ID" value="CCC78778"/>
        <property type="gene ID" value="lp_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1447"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1211"/>
    <dbReference type="eggNOG" id="ENOG5030B4Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012347_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1239-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388055" evidence="2">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="13469" checksum="5E489EB0C6FCE782" modified="2011-10-19" version="1">MAKFRRLVLLSLSLGLALAGGCRSPDALAATPTDTSVTLTDWQAGTDLTNFQHPRPYQYLAVPNIIATANQQASTQTPSSAAIRPDQSVLPQTNEARQLLVWLGLLTAILAGWLVWLMQRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ5</accession>
    <name>F9UNJ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, histidine triad family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889298.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1454"/>
    <dbReference type="EnsemblBacteria" id="CCC78784">
        <property type="protein sequence ID" value="CCC78784"/>
        <property type="gene ID" value="lp_1454"/>
    </dbReference>
    <dbReference type="GeneID" id="57025085"/>
    <dbReference type="GeneID" id="66449287"/>
    <dbReference type="KEGG" id="lpl:lp_1454"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1217"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_9"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="PhylomeDB" id="F9UNJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1245-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="150" mass="17053" checksum="A2923257F8625B49" modified="2011-10-19" version="1">MTAFEPKLDDDCIFCKIIKGDIPSYTVYEDDMVKAFLDISQGTPGHTLVVPKTHVADIFGYDRDLASIVFARIPEIARAIKATDENIIGMNIVNNNGAVAYQSVFHSHFHLIPRYSDKDDFRMIFKDNAKKYDETDYTRLQNAIKTELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK9</accession>
    <name>F9UNK9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufD</name>
        <name evidence="3" type="ordered locus">lp_1469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101418.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889312.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1469"/>
    <dbReference type="EnsemblBacteria" id="CCC78798">
        <property type="protein sequence ID" value="CCC78798"/>
        <property type="gene ID" value="lp_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1469"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1231"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_3_0_9"/>
    <dbReference type="OMA" id="PNCESHQ"/>
    <dbReference type="PhylomeDB" id="F9UNK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1259-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="433" mass="47471" checksum="CE548419F06110C0" modified="2011-10-19" version="1">MEATADYETIKTTLAAAANEHGEPHWLVERRLAALDAMQGLAVPKADRFSICDWPLTPTDQPLKFSRSDRTLATDVTAEAGHIQIVQVGQTTVTVNLPDELDDQGVILTDMFTAFREHPQLTEKHFMGKVVKTDEDRLTSYHTAFLNAGVFLYVPKGVTVKEPIEITTIQDSTRVQPLISHVLIVAEQDSHFAVTQHLTTKGDVDNIANCVVEILARADSEVHFSAFDELGANTTAYLNRRAAISRGAKVDWAIGMMNNGNTFGDFDSELISEGAKSDAKVITVTTKAQDVCVNTRVTNRGKKTDGNIVQRGVIMEKSNLIFNGIGHIIHGASGAHAEQENRVLMMSDDAHGDANPILLIDENDVLAGHAASVGQIDQNQMYYLMSRGIDKPQAQRLVIRGFLSTVIGAIPSKTVRTRLTNTIERKLEDGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM7</accession>
    <name>F9UNM7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensor histidine kinase</fullName>
            <ecNumber evidence="12">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hpk4</name>
        <name evidence="15" type="ordered locus">lp_1488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Autophosphorylated.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1488"/>
    <dbReference type="EnsemblBacteria" id="CCC78816">
        <property type="protein sequence ID" value="CCC78816"/>
        <property type="gene ID" value="lp_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1488"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1250"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_0_9"/>
    <dbReference type="OMA" id="HDSIGHE"/>
    <dbReference type="PhylomeDB" id="F9UNM7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1277-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017203">
        <property type="entry name" value="Sig_transdc_His_kinase_NreB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037432">
        <property type="entry name" value="STHK_NreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="152"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="13">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037432-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="343" mass="38291" checksum="54BC882BAB4DBC7F" modified="2011-10-19" version="1">MLESNHWIQQYFSEATDAVLIFKDDQLVISNQLARDLQAELNFDPNYLVQIADNAVQQKFNTTDDCFDCVIRNLMPEISIPITLAKDKPHPLTYFLIYHVINTDERIFSLTLKSRGTIKRMDQLAQQRQLNAYVNRAHEEERKKISADLHDSIAQGIYSAIMGVRRINAEHANPDEISALTHVIETQLEDTLTEVKGMALDIRPSVLDNFGLLAALRALAKRLQANSGVTITVTGNDEPTQLATDVQNVLYRIGQESINNALKHAHANEINLLLVAHSHYITLEIIDDGQGFNVPDQATFNGHSLGLLNMNERVKALNGTFTLHSQPGAGTSVTAKFPMTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN6</accession>
    <name>F9UNN6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">narG</name>
        <name evidence="14" type="ordered locus">lp_1497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889339.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UNN6"/>
    <dbReference type="STRING" id="220668.lp_1497"/>
    <dbReference type="EnsemblBacteria" id="CCC78825">
        <property type="protein sequence ID" value="CCC78825"/>
        <property type="gene ID" value="lp_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1497"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1259"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_9"/>
    <dbReference type="PhylomeDB" id="F9UNN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1286-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028189">
        <property type="entry name" value="Nitr_red_alph_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044906">
        <property type="entry name" value="Nitr_red_alph_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14710">
        <property type="entry name" value="Nitr_red_alph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1223" mass="137761" checksum="AB87464441B13F68" modified="2011-10-19" version="1">MKKSRFFKNVEKFNGTFTQLEENSRRWERLYRERWSHDKVVRTTHGVNCTGSCSWNVYVKQGIITWEHQATDYPECGANMPGYEPRGCPRGASFSWYEYSPVRIKYPYIRGKLWQLWTEAKQTHDNPLAAWASIVENPAKTKIYKSARGHGGMVRVHRPEALELISAMLLYTIKTYGPDRLAGFTPIPAMSMISYASGARFMSLLGGEMLSFYDWYADLPPASPQIWGEQTDVPESADWYNSQYIMMWGSNVPLTRTPDAHFMTEARYHGAKIVAVSPDYAENVKFADNWLAPHPGSDAALAQGMTHVILQEFYQNKQTPEFLNYAKQYTDLPFMVILKPSAANSNDYTSGRFMRISDLQGTDTVANAEWKPVVYDRNQAKVVVPNGTIGQRWEAGQQWNLTLKDADGQAIDPQLNITAEQQVTIDFPTFDADGNGVLKRHVPVQTVTFADGSQQLVTTVYELMLAQYGIDQGNHDQLAASGYDDTNSRYTPAWQETVTGVKASLVVQIAREFAQNALDTGGKTMVIMGAGINHWFNSDMTYRSIINNLMLCGCEGVSGGGWAHYVGQEKLRPQEGWGAIAFANDWQAGGARQQNGTSFFYFASDQWKYDELDNEAQKSPVSASKHAYEHAADYNQLAIRLGWLPSYPQFDRSSLAFAKEYQSTDINEISQHVVDELKSGQLHFAAENPDANQNQPKGLFIWRSNLFTSSGKGQEYFMKHLLGAENGLLAKSNSRCQPEEMVWNDDTVTGKLDLVIDMDFRMVATPMYSDVVLPAATWYEKADLSSTDMHPFIHPFNAAINPMWESKSDWQQFKTLAKTFSTMAKKYYPEPQYDLKTQPLGHDSKGEISQPLGEIRDWKKGEIDAIPGQTMPALSLIKRDYTQVYDKYIALGPNARGKEGGLGFSYDVTTEYDELKDILGVYDRGVNAGCPKLDQDKRVVDAILHISSTSNGHVAKKAWANAETVTGRSLSDISAGRTEEQMSFKSITVQPAEAIPTPIFTSAKHDGDRYSPFTVNIERLVPFRTLTGRQQFYLDHEIFQEYGESLANYKPTLPPQVMAPGDTEIAPADNELTLRYMTPHGKWNIHTMYYDNLEMLTLFRGGPNVWLSPVDADKAGIKDNDWLEIYNRNGVVTARAVVSHRMPAGAMYMYHAQDMEIQEPLSTITGNRGGSHNAPTQIHVKPTQMVGGYGQLSYGFNYYGPIGNQRDLYVNVRKLKKVNWNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ8</accession>
    <name>F9UNQ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644291.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1522"/>
    <dbReference type="EnsemblBacteria" id="CCC78847">
        <property type="protein sequence ID" value="CCC78847"/>
        <property type="gene ID" value="lp_1522"/>
    </dbReference>
    <dbReference type="GeneID" id="57025118"/>
    <dbReference type="KEGG" id="lpl:lp_1522"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1281"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_0_9"/>
    <dbReference type="OMA" id="PGITTRM"/>
    <dbReference type="PhylomeDB" id="F9UNQ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1308-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13186" checksum="059A39972EDDD17F" modified="2011-10-19" version="1">MQRQVYDCTPGCPVESTLQVIAGKWKSVILYHLFTAGTCRFSILQKRLPGCSRRMLARQLQELVQDGVIAKRVYPVVPPKTEYWITPFGQTLKPVIMAMETWGRQYNSVNGKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV6</accession>
    <name>F9UNV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glpQ2</name>
        <name evidence="2" type="ordered locus">lp_1578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889409.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1578"/>
    <dbReference type="EnsemblBacteria" id="CCC78895">
        <property type="protein sequence ID" value="CCC78895"/>
        <property type="gene ID" value="lp_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1578"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1329"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_9"/>
    <dbReference type="OMA" id="TEYIGIE"/>
    <dbReference type="PhylomeDB" id="F9UNV6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1356-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="244" mass="27993" checksum="18282368A5969F17" modified="2011-10-19" version="1">MLTQIIAHRGSKGTRPENTLPAFIAAIEDGADGIETDVHLSRDGQLIIMHDELVDRTTNGTGRIVDHTLAELKQLDAGVKYASAYAGTRIPTLDEVVQLLIQYNFTGIFNLEIKTNKIHYEGIEDLVADYFNHHQVPFTLIYSSFYGKSIERLHILQPEVESDSLFKTKVQTAKRLHAQHIVLGYHPDIRWVRVHWLLLPKVQLRPWTVNTERDMRFCYRHRFAGLITDYPGLARRIRKQVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW8</accession>
    <name>F9UNW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein, DUF464 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101496.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1663"/>
    <dbReference type="EnsemblBacteria" id="CCC78967">
        <property type="protein sequence ID" value="CCC78967"/>
        <property type="gene ID" value="lp_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1663"/>
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    <dbReference type="eggNOG" id="COG0786">
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    </evidence>
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            <dbReference type="EMBL" id="CCC78967.1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>F9UPE6</accession>
    <name>F9UPE6_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101555.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1799"/>
    <dbReference type="EnsemblBacteria" id="CCC79085">
        <property type="protein sequence ID" value="CCC79085"/>
        <property type="gene ID" value="lp_1799"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG50309UV">
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            <end position="22"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="244" mass="25337" checksum="C87149EE97D2916D" modified="2011-10-19" version="1">MPEQKQTRMSRLKAREATGGKRGRKASSQGSHAPKEPNDPKKPQAPKSPQKKHHVSLWLLALIVIALGGTVVYFVKAASNQDLVETTSSSSSSKARKKSSSKKSSSTSKKKKKHSSSSSESTSETTAASTDADTSTDGTETTGAYSSSTATNTTAGNTTASSHSTTASHQTTTSSATSHSTSTASSSSKSETSSTSTEKSSSSSHSGSTYDNLDDAKDYGENSISGNYKVTTDSNGSYHVSKAD</sequence>
</entry>
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    <accession>F9UPG8</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889621.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1825"/>
    <dbReference type="EnsemblBacteria" id="CCC79107">
        <property type="protein sequence ID" value="CCC79107"/>
        <property type="gene ID" value="lp_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1825"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1543"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536163_0_0_9"/>
    <dbReference type="OMA" id="LIWIFLM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1570-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="508" mass="57358" checksum="B713676454740DBD" modified="2011-10-19" version="1">MPMKWCYKIFQITVLTIAAALLGWMIVANWQVNLKLHLAISAWIGAGLFVLFIGATIGLGSWWLSRHQTSWLVAALMGLTILKFPLVAGLKIDPTSDFWNYHTLAAFSAQGFTWTQLLHHGIVGNYVVFPHALNIANGYSLVAAFGGANFFVSQLINIGCTLVDMVLIYWLVARWLSRQLGIMAALIFYWIPAYWLYGTLLNGGEPFFFTSVLLMMYALTRALVPLTTTTITDRRLYLALAIVMTVVANMLRPIMGVWLIALGLMSLCVLLKSHHLYRVQVRQLLIYSAVVLGLMFTATNLDSWLYGFKVAPAQVETLYSLATGTDVKSHGTYSPALQATVSHELRVAPTLTQAYPRITRTMARTLQTNLKQIKPQLGSFVNEKMQGFIREDYGYDWSLYNLSHHPGLLNRHWFYLAPILITSATVYWQAMLVIALFSVLMGLGLLWHQHYLNHYLLMASLLLDGFTLSALPLEVQGRYHIILYLPILMLMTCGIAEAKLWRRQIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPK5</accession>
    <name>F9UPK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101579.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1876"/>
    <dbReference type="EnsemblBacteria" id="CCC79144">
        <property type="protein sequence ID" value="CCC79144"/>
        <property type="gene ID" value="lp_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1876"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1581"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_5_0_9"/>
    <dbReference type="OMA" id="HSYAMQE"/>
    <dbReference type="PhylomeDB" id="F9UPK5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1606-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="265" mass="28953" checksum="AC280311230678F6" modified="2011-10-19" version="1">MKVAIIATDLDGTFLRDDHQFDHHRFQAQLDQMNAQGQHFVVASGNQLQHCIDVFDGINGELTYVAENGGLVIDNHGNVLAESLIEPALYQELLIYVATEPALAGAEISVSGKQGAYIRPQDDSPIMRYYLSRLQVVPSLSAIDDHIYKATFSWQATDADAHAALINQQFAGRLRATVSGGNGLDVIPPHVNKATGLAYLQQHWHVAPSQTAAFGDNGNDLEMLREADYSFAMQNAIAPVKEMATYLTSHDNNHDGVLATIDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL4</accession>
    <name>F9UPL4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889667.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1886"/>
    <dbReference type="EnsemblBacteria" id="CCC79153">
        <property type="protein sequence ID" value="CCC79153"/>
        <property type="gene ID" value="lp_1886"/>
    </dbReference>
    <dbReference type="GeneID" id="57025479"/>
    <dbReference type="KEGG" id="lpl:lp_1886"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1589"/>
    <dbReference type="eggNOG" id="COG4955">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066169_1_0_9"/>
    <dbReference type="OMA" id="WGTIHFL"/>
    <dbReference type="PhylomeDB" id="F9UPL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1615-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008308">
        <property type="entry name" value="UCP021350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021350">
        <property type="entry name" value="UCP021350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_40" evidence="1">
        <location>
            <begin position="248"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="347" mass="39527" checksum="A498615A5AE8C9D6" modified="2011-10-19" version="1">MFTDYVLLLFSTTPRRAKGLFNVLRGRRTVSTLFAGLTAGYLDLLDSCHEVPLEDFMAATAALTENGQLTSTATGCWQLTQAGEHRQAKLRQTLYMPQNFEVFQTTDVRRFRIVSQLALQVVSELVHHDRHYYPVTTDPGIQAQVKQWLRQQSKVELGEQIHAALTAFLTSLADPELPTVFVQGITGYQEPGLTNEQLAAQLGRQPWEASLMHTDVICQWIAWIQRHPRDPFSQLLSVLTQASAISQSAEQTYQAFLKTQQLAAIAQTRHLKMSTVREHLLEVAIWSPDFPFEMVLNHEITQQLATIFAAQPDIANWSFQEAQAALPTLDFFEFRLFQIMRCQHVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN9</accession>
    <name>F9UPN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79178">
        <property type="protein sequence ID" value="CCC79178"/>
        <property type="gene ID" value="lp_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1916"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1615"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047714_2_1_9"/>
    <dbReference type="OMA" id="APHLWYN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1640-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="368" mass="42994" checksum="74D4FBEDC55BFD80" modified="2011-10-19" version="1">MTMISSPSMEVTDVGDYLKLGACTAVMAQPILTDALASGPSIATQTGIGVVYNLVKYTAPAFIFGILYTTTRLTLNQTALTYTDYLRQQWHALFIPTIWWTAIYLILMPQLQQGSQYHDWRGFLWQFVNGNAAPHLWYNTMMLQFIILMPLFWALGRWCQSRPRRGWIVFGGTTLVAVLWLWFYDQQVFHGPHSRDWYLLDRLFISFQIFGFYGMLAWVFRDTFQRMLNKWWPGLLGLWLVCLIWTNWELFSYGFPVNLRNAPYYKPSMTGYALAVIGLLAALCEIQVRRQRHFSKFVHLFAGMAYKAYLANVFWSELLWRGFGRTLMVKAPWLSIALCYGLTWLLSFTTAFGLHAGWMRLKREYEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP6</accession>
    <name>F9UPP6_LACPL</name>
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        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ordered locus">lp_1925</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889699.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1925"/>
    <dbReference type="EnsemblBacteria" id="CCC79185">
        <property type="protein sequence ID" value="CCC79185"/>
        <property type="gene ID" value="lp_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1925"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1622"/>
    <dbReference type="eggNOG" id="COG0446">
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    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="DKNHTNY"/>
    <dbReference type="PhylomeDB" id="F9UPP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1647-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889728.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1958"/>
    <dbReference type="DNASU" id="1061810"/>
    <dbReference type="EnsemblBacteria" id="CCC79214">
        <property type="protein sequence ID" value="CCC79214"/>
        <property type="gene ID" value="lp_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1958"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1654"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="EDIERMC"/>
    <dbReference type="PhylomeDB" id="F9UPS5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1678-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="33904" checksum="E263FA2F5714E0CF" modified="2011-10-19" version="1">MSIQVKALSKRIDNREILRGITFTWQPGRIVGLVGRNGVGKTTLFRTMADHYLADEGELVIEGQSTLQQPYCRQKLFYIDTQRHFFGGRRLRQIITTYALAYDDFDQSQLTALLAAEHLSTKSYYQRLSKGQQMLFQILLALASHVPYIILDEPFDGLDIIVRERIVAYMVEEVAEHGVSFLISSHNLDELDGLCDQVLFLQHHELVADYDLESLRATARKFQLVFADKHIPAVVKEHGQLIKVYGRVLEVYFADYTPTIETALQQTQPLMMAVQPLTITDVFRVKLGDRQAVWGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX2</accession>
    <name>F9UPX2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2013a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889775.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2013a"/>
    <dbReference type="EnsemblBacteria" id="CCC79261">
        <property type="protein sequence ID" value="CCC79261"/>
        <property type="gene ID" value="lp_2013a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2013a"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2862205_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1723-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="64" mass="7044" checksum="4519BBCE1E4EDB81" modified="2011-10-19" version="1">MSGVLDLYSRHLIAHKLSETETTNAEVQVFQRAFNFAGDVHPVVHTGRGSAYTSVVFNNFFGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ26</accession>
    <name>F9UQ26_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional attenuator, cell envelope-related, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889829.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2075"/>
    <dbReference type="DNASU" id="1061632"/>
    <dbReference type="EnsemblBacteria" id="CCC79315">
        <property type="protein sequence ID" value="CCC79315"/>
        <property type="gene ID" value="lp_2075"/>
    </dbReference>
    <dbReference type="GeneID" id="57025621"/>
    <dbReference type="KEGG" id="lpl:lp_2075"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1757"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_2_1_9"/>
    <dbReference type="OMA" id="YIAMANH"/>
    <dbReference type="PhylomeDB" id="F9UQ26"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1775-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="88"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="394" mass="45092" checksum="7F43EF5674CEB70B" modified="2011-10-19" version="1">MKCGGTEFMRRRQLPKWQRKRLIVLVTSCITFMLVAFTIQGIRLFDMLHSFHESRVIKSHHNLTQQPVSTFLLMGLDNSGKRKLSTTRTDGMMVVIVNHKTKTMTLCSLLRDTFVKIHSQQYHGYQRIESAYTYGGDAAAIATVEHYLNLPIDYYLTVNWDGFIRAIDDIGPVEVNVDRDFIGQDYWGKPEKFKAGLQSMSGARALAYARERHIDNDQHRGFRQQAVFYAMVKRLNQEGLSSKGAKVVGDLKDQMRTNLTNHDMLTLFKSRKTFKRYRVKRLTFQWRTFDVAGRSMVEVYPDSRVQVSRQLQAAAGLRPDLPSQTFTTNGHYRYASDESVESKADEAKADTHYGQSHVYVGHAGNTTIGKLPAAVPLKNGFRVSDRTETMYTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ78</accession>
    <name>F9UQ78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N6-adenine-specific methylase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101663.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889881.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2134"/>
    <dbReference type="EnsemblBacteria" id="CCC79367">
        <property type="protein sequence ID" value="CCC79367"/>
        <property type="gene ID" value="lp_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2134"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1808"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_0_9"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="PhylomeDB" id="F9UQ78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1828-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="20648" checksum="AA40EAAE154979F8" modified="2011-10-19" version="1">MRIVAGDFGGRRLKAVPGMQTRPTTDKVKEAVFNIIGPYFDGGQSLDLFAGSGGLSIEAVSRGVARAVLIDRQYQAIKTIKDNIAVTKVPERFEVIKGDAERILDRLASQDEHFDWVFLDPPYAKQQIVKDIQHCDALGLLNPGCRVICETDTNANLPTVLPGFELIRQQDYGITVITIYQKVTEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ83</accession>
    <name>F9UQ83_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2 (GT2), TIGR03111 family</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ica2</name>
        <name evidence="2" type="ordered locus">lp_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101666.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2142"/>
    <dbReference type="EnsemblBacteria" id="CCC79372">
        <property type="protein sequence ID" value="CCC79372"/>
        <property type="gene ID" value="lp_2142"/>
    </dbReference>
    <dbReference type="GeneID" id="57025678"/>
    <dbReference type="KEGG" id="lpl:lp_2142"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1813"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603805_0_0_9"/>
    <dbReference type="OMA" id="YKMFIRW"/>
    <dbReference type="PhylomeDB" id="F9UQ83"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1833-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017542">
        <property type="entry name" value="Glycosyltfrase_exosort_G_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03111">
        <property type="entry name" value="glyc2_xrt_Gpos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="52687" checksum="956150B9C4C687ED" modified="2011-10-19" version="1">MYWINLALTRMGFWITWALVPIVVEIIPAIMSTIKLMRLHRHMPRLKAPAKWPWVTIIVPVYNSEDTLFDCIRSIDHQTYDKKSMQIILANNQSTDDSFGAYARAQNAFPNLFLRYVNTDKGKARALNAAIYESIGSYVINIDSDGLLEPNAIKNMVLRFENDEQIAAMTGAVLPQRNLVKQVHGWWHRLLAKNEYYEYAQAFLSGRTIESFRDQLFTMSGAFSAFRREVLMETFLYDTDTIGEDTDMTFQIRTRLGKKVVICADAIFYVAPISGFSELYTQRQRWQRGELEVAQHYMSQTASIKGFFKEFLVRRIMIDHTFTFPRMIWTFATIVLIAFGYSTVVVGLSYLLIYSLYVMVGVINFISVGILLKPYPEERHFYKHLWWLTLTLPLYMFLTAWIRLIGVINAMTTQATWKMRGFTEEWQRLLAVLRDDRRTIHNHYRRRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC0</accession>
    <name>F9UQC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein, RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2190"/>
    <dbReference type="EnsemblBacteria" id="CCC79409">
        <property type="protein sequence ID" value="CCC79409"/>
        <property type="gene ID" value="lp_2190"/>
    </dbReference>
    <dbReference type="GeneID" id="57025718"/>
    <dbReference type="KEGG" id="lpl:lp_2190"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1850"/>
    <dbReference type="eggNOG" id="COG2302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075687_2_0_9"/>
    <dbReference type="OMA" id="MSRSKMV"/>
    <dbReference type="PhylomeDB" id="F9UQC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1870-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlmH_RBD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="29675" checksum="C8646B134829A0F7" modified="2011-10-19" version="1">MNDNLKQHFRDSEAPFIEQVTGWLRQVADQYRPILTAFLNPRQIYIAQTLVNQLDDVRMRASGGFEGAELQRILFYPVYYEPEVADFQITLFNIVYPVKFATLKHGQILGTLANAGVERDVFGDIVTDGTTWQFVCETEMASYFEEQIDRFGKTKVHLTAVPLSAVITPEDDWEAVTTTVSSLRADSIIKAAFNLSRHHAKELIEGAKVRLNWADLPKADYELALLDMLSVNHYGRVRLAEISGETKKARLRITLNIIHSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-01-25" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC5</accession>
    <name>DIVIB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein DivIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">divIB</name>
        <name type="synonym">ftsQ</name>
        <name type="ordered locus">lp_2195</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsQ/DivIB family. DivIB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101680.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889928.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UQC5"/>
    <dbReference type="STRING" id="220668.lp_2195"/>
    <dbReference type="PRIDE" id="F9UQC5"/>
    <dbReference type="EnsemblBacteria" id="CCC79414">
        <property type="protein sequence ID" value="CCC79414"/>
        <property type="gene ID" value="lp_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2195"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1855"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046278_2_1_9"/>
    <dbReference type="PhylomeDB" id="F9UQC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1875-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00912">
        <property type="entry name" value="DivIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026580">
        <property type="entry name" value="DivIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000414772" description="Cell division protein DivIB">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="2">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32640" checksum="A4ECF02E6CC5B516" modified="2011-10-19" version="1">MAIFHKKPKEREHPEQLTPWERFQRDAAENHRAAQKSHHSWSGKRLRIGDKLPKLKSQRRRLLFKRVVILMGCFLIGAGVAGYFISPLSHVQTVTVHGNDQLSVTQVKTATKINPGVALWSVIGHDQRTTKRAERAQPQIGKVTTKLVGLNSVRVTVKEIRIAGYLSTGQHYRRILENGLILKVTYSQPGGGSPIYANFKSGHRLATMIAQYAKLPSAVKHNISEIKFAPNKANPERVHLYMNDGNEVYATISTFASKMAYYPGIVAKMKTKGVINLEVGAYSYPFKNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD6</accession>
    <name>F9UQD6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspR</name>
        <name evidence="4" type="ordered locus">lp_2211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2211"/>
    <dbReference type="EnsemblBacteria" id="CCC79425">
        <property type="protein sequence ID" value="CCC79425"/>
        <property type="gene ID" value="lp_2211"/>
    </dbReference>
    <dbReference type="GeneID" id="66449960"/>
    <dbReference type="KEGG" id="lpl:lp_2211"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1867"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_0_0_9"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="PhylomeDB" id="F9UQD6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1886-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19524" checksum="D77C65B16A01ABF8" modified="2011-10-19" version="1">MTNHIALFEPLMPANTGNIARTCAGTDTALHLIEPLGFKIDDKHLKRAGLDYWDSVDITYHADLQDFLASIPDLNQLYLVSKFAEHDYTDVDYSDTGKDHYFLFGKETTGLPEPFMRKYPEKAIRIPQDDSHIRALNLSNSAAIVIYEALRQQQFPNLERSHHYENDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE5</accession>
    <name>F9UQE5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD2</name>
        <name evidence="5" type="ordered locus">lp_2221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640877.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889948.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2221"/>
    <dbReference type="EnsemblBacteria" id="CCC79434">
        <property type="protein sequence ID" value="CCC79434"/>
        <property type="gene ID" value="lp_2221"/>
    </dbReference>
    <dbReference type="GeneID" id="57025744"/>
    <dbReference type="KEGG" id="lpl:lp_2221"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1876"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_8_2_9"/>
    <dbReference type="OMA" id="PKTHVYR"/>
    <dbReference type="PhylomeDB" id="F9UQE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1895-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="86"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="33674" checksum="B8AC86A25175C71E" modified="2011-10-19" version="1">MRFTWINHETTPMKVKTLLAQHGVTRSLLKKVKFHGGAILVDERPVLAIHMLTGGETVTMVTPAEIGNDHLGVSTLPIDILYEDRDYLIVNKPAGVASVPAHALPDNTLANRVKGYYQAAHYDNEVVHITTRLDRDTSGIVLFAKHHFAHSIIDHQLKAHAMRKMYLAVVSGELTTDHGWLDAPIGRAADSFIKRTTRPDGKPSLTEYWVVKRLRNMTVVRVRLHTGRTHQIRVHFAASGHPLIGDALYGGPRDPWIQRQALHCMQLEFDDPFISQTLTTFAPLPADLNRLIIHNQRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP2</accession>
    <name>F9UQP2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890045.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2337"/>
    <dbReference type="DNASU" id="1062358"/>
    <dbReference type="EnsemblBacteria" id="CCC79531">
        <property type="protein sequence ID" value="CCC79531"/>
        <property type="gene ID" value="lp_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2337"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1976"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_1_2_9"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="PhylomeDB" id="F9UQP2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2015-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="426" mass="46138" checksum="F6C644E0EBFB278E" modified="2011-10-19" version="1">MQQPLAYRMRPKTLKDVVGQQQLVGPGKIIARMVKAKRLSSMILYGPPGTGKTSIASAIAGSTKYAFRMLNAATDSKKQLQIVAEEAKMSGTVILLLDEIHRLDKTKQDFLLPHLESGRIILIGATTENPYISINPAIRSRTQIFQVFPLTDDDIQHAVERALADEKNGLGSYHVDLAPAAMHHLCTATNGDLRSALNGLELAVLSSSPADDGTIAISQQTIEECLQKKALSADKDGDAHYDVISAFQKSIRGSDVNAALHYLARLVEAGDLKSIMRRLMVIAYEDIGLANPAACAHTVAAVQAADQLGFPEARIPLADAVIELALSPKSNSGISAIDAALTTVRDGHFGDIPADIKDAHYQGAAKLGHGVGYDFPHDHPGDWVAQQYLPDAIKSAKYYEPKTNGRYETALAQQYEKLLKANERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS4</accession>
    <name>F9UQS4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ordered locus">lp_2377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2377"/>
    <dbReference type="EnsemblBacteria" id="CCC79563">
        <property type="protein sequence ID" value="CCC79563"/>
        <property type="gene ID" value="lp_2377"/>
    </dbReference>
    <dbReference type="GeneID" id="57025907"/>
    <dbReference type="KEGG" id="lpl:lp_2377"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2009"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_2_9"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="PhylomeDB" id="F9UQS4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2048-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="31637" checksum="AFFA16EBCCB7D662" modified="2011-10-19" version="1">MNKPTQPTYFEAQQWASFCLKTAQLPTDSARFLLLGLSRLDQTQLLIRYREPLPSAVWHAYQQGIDRVVAGEPVQYVLGDAPFYGLTLQVDPAVLIPRVETEELVDWILTDVPATAPVRLLDVGTGSGAIALAIKHERPAWEITASDISTAALQVAKANADRLHLDVKLVHSDLLTSVSAQPFDIIVSNPPYIAASEKDVMDASVLAHEPQTALFADHDGLALYEQLATTVADHLTSTGRLYLEFGYHQGPALQTLFAQSMPDATVTLRQDMAGHNRMLRVAMTLTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR50</accession>
    <name>F9UR50_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642739.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890203.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2525"/>
    <dbReference type="DNASU" id="1062711"/>
    <dbReference type="EnsemblBacteria" id="CCC79689">
        <property type="protein sequence ID" value="CCC79689"/>
        <property type="gene ID" value="lp_2525"/>
    </dbReference>
    <dbReference type="GeneID" id="57025953"/>
    <dbReference type="KEGG" id="lpl:lp_2525"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2125"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="OMA" id="GQQARFQ"/>
    <dbReference type="PhylomeDB" id="F9UR50"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2182-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="319"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="517" mass="57993" checksum="EF4C2B713D24299D" modified="2011-10-19" version="1">MALLEVTDLSQSFADRKLYDDANFTLERADHMGIVGQNGAGKSTLIKILTGQILPLSGQIKWQRNVRTGYLDQYADIPAGMTLYAFLKTAFQRLYDLDAQMQQLYADYAEKMDDQLLERAGRIQETLEANNFYDVETEMERVITGLGLDEIGRDHVISEMSGGQRSKIILAKLLLENPDVIILDEPTNYLDTAHISWLEDYLNGFEGAVMVISHDYDFLQQVTNCICDVAFGKIIKYRGDFKAAMRQKEARKEAQLKAFEKQQVVIEKAEKFIRKNKAGSKSTMAKSREKMLSHLDRVDPPSENEHAKFAFPYLDTGSQNALSVTKLSVGYGKPLLEPVTFTMTNGEKLAFKGFNGVGKSTLIKSILGVIPALSGKSDFSPSAKINYFNQDLEWDNPQLTPLQTIQNEYPTMLPKTIRTKLAKCGINAANAMKPMHLLSGGEQTKVKLALLELVPSNFLIMDEPTNHLDDETKEGLKRALQAFQGNLILVSHESSFVNGWVDKELNVEKLSLKERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC2</accession>
    <name>F9URC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface hydrolase, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2620"/>
    <dbReference type="ESTHER" id="lacpl-LP.2620">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79761">
        <property type="protein sequence ID" value="CCC79761"/>
        <property type="gene ID" value="lp_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2620"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2200"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_3_9"/>
    <dbReference type="OMA" id="EDCGYTN"/>
    <dbReference type="PhylomeDB" id="F9URC2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2252-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="85"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="307" mass="34156" checksum="8F112857A1161DFB" modified="2011-10-19" version="1">MKKWWITLGVLVVLVAGAVIGAGSYFYHVAIARGDKSFVTQSTKLSKKSSVYHQKYWYLHARKQTWTIESSDHLRLVAWYIPVKNSKRTVVLAHGFAGNKGLMGAWAGMYHELGYNVLVPDSRASGASQGKAVGYGWLERRDDLQWAKTVVHKTATTQIVMSGISMGAAGMTMASGERQLPQIKAYVVDSPFTSADAIISYQAGQLYHLPAFPLVNVTSLITKLRAGYSFKEADAVAQIRKNHLPIMIISGTRDDFVPTSMGKTLYRNAHQPKSLWLVKGAGHTTAITQNYQRYKRHVTAFLEQYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP9</accession>
    <name>F9URP9_LACPL</name>
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        <submittedName>
            <fullName evidence="6">PTS system, cellobiose-specific EIIB component</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pts20B</name>
        <name evidence="6" type="ordered locus">lp_2781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890402.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2781"/>
    <dbReference type="EnsemblBacteria" id="CCC79888">
        <property type="protein sequence ID" value="CCC79888"/>
        <property type="gene ID" value="lp_2781"/>
    </dbReference>
    <dbReference type="GeneID" id="49394889"/>
    <dbReference type="GeneID" id="57026149"/>
    <dbReference type="GeneID" id="66450426"/>
    <dbReference type="KEGG" id="lpl:lp_2781"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2328"/>
    <dbReference type="eggNOG" id="COG1440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147323_1_1_9"/>
    <dbReference type="OMA" id="DAEIFAC"/>
    <dbReference type="PhylomeDB" id="F9URP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2379-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389071" evidence="4">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="105" mass="11341" checksum="CA815219779483FD" modified="2011-10-19" version="1">MAERTIMLVCAAGMSTSLLVSKMQKAAEAEGIDADIFATAASDADAKLAEKNPDILMLGPQVRYMLSDFQKRVDIPVEVINMQDYGMMNGEKVLKEAEASIAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ0</accession>
    <name>F9URZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS), C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2897"/>
    <dbReference type="EnsemblBacteria" id="CCC79979">
        <property type="protein sequence ID" value="CCC79979"/>
        <property type="gene ID" value="lp_2897"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2897"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_7_0_9"/>
    <dbReference type="PhylomeDB" id="F9URZ0"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="343" mass="37029" checksum="275F9D37FCE0F76C" modified="2011-10-19" version="1">MFQLIFTYVPRNQLGTYTGLASVIVSLAPALGPTYGGILTSVWSWRAIFVGIVPLLALLAILGAFNISGKALGVGDKKFDYLGAILLAITFTSLLFMFNNAGTHGWLSPNFGLWCLWSIVMIGAMVTYAIKGRRQLIDYSILKLPILRLRLFNYFGLQFINIGLSFVLPLFAQTVLGASAMTAGLMMLPGAIVGAITGPIAGRIYDKQGPTTLLTFSAIMASAALLLFWLTTDYFTVIIMAVIYALLRVGFNTGFGTAISDGSTRVPLPQKSDQNSMFSMMQQYAGSIGTSIMSAVIAGYEIHHPTVTGTIMGSKLDFLLLFVLAIAILISVLHVKRLEIGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9US17</accession>
    <name>F9US17_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="7">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdG</name>
        <name evidence="8" type="ordered locus">lp_2931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644787.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890520.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2931"/>
    <dbReference type="EnsemblBacteria" id="CCC80006">
        <property type="protein sequence ID" value="CCC80006"/>
        <property type="gene ID" value="lp_2931"/>
    </dbReference>
    <dbReference type="GeneID" id="57026277"/>
    <dbReference type="KEGG" id="lpl:lp_2931"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2448"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089926_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9US17"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2502-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="193" mass="22011" checksum="9C633C9CF9A135EA" modified="2011-10-19" version="1">MPRATKGPNNPMPKEWLAEDLSEQYVADYKAFNFVDGEGVRCSLYLSGCPFHCPGCYNVAAQNFHYGQPYSQELEDQIIEDLGQDYVQGLTLLGGEPFLNTQVGIRICERIRSEFGNTKDIWSWSGYTWEELQQDSEDKLKMLSLIDILVDGRFLQDKMDLSLQFRGSSNQRIIDVPKSLTAGKVVIWDKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9US45</accession>
    <name>F9US45_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641639.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0015"/>
    <dbReference type="EnsemblBacteria" id="CCC77592">
        <property type="protein sequence ID" value="CCC77592"/>
        <property type="gene ID" value="lp_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0015"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.13"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_9"/>
    <dbReference type="OMA" id="WESNLSV"/>
    <dbReference type="PhylomeDB" id="F9US45"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-13-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="407" mass="45622" checksum="B76A7CAC79FD659D" modified="2011-10-19" version="1">MAQKQLIKTPWLIAGQFMNNIGMSFIWPLTTIYMHNVLGKSLTETGIVLMLNSVANVLASTIGGRIFDRGNPYHLLLMGITLNGLANFALIFFHGWPWYPMLLVVTGFASGWLNTMFNALAASVPRDKVRRTFTLMYLAANLGVVFGTMLVGIVYSMGMALLFSMTTSLFVIFLIIALFEYNVDSSNVTGVDPRQGQDVHLPRANFHIVWTFFISLFIIWLLYEQWVSNLSVYMTNLGMPLRNYSFLWTINAGLLVLIQSILSLLGNRIKNLYNQFFFGMLFVGLSFLSLVIAHDYPHFIFAMILLTIGEATWSPAMPTLVSQLSPVSAKGRYQGLVQAFCALGRSLGPLFGGVIIDNWSYKVLFLLAFVVLLIVLAVNIGVVHFNLRKAVNYMKTDVQTDVSRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA4</accession>
    <name>F9USA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890548.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2972"/>
    <dbReference type="EnsemblBacteria" id="CCC80034">
        <property type="protein sequence ID" value="CCC80034"/>
        <property type="gene ID" value="lp_2972"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2972"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2479"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="VMLHQGN"/>
    <dbReference type="PhylomeDB" id="F9USA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2530-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="28315" checksum="7B783B34D9146917" modified="2011-10-19" version="1">MPQPTILNVQHLQKVFFPGTSNERHVLKDVNLTIEPGEFVAVIGNNGAGKSTLLNTIAGTLNTDAGEITLANHRVTNRPVAYRSRWVARVFQDPKLGTAGELSVAQNLTLAQRHTGSLSLRRYRQRGQEERYLRLLASLNMGLEARLNTQVKYLSGGQRQALSLLMATLSQPELLLLDEHTAALDPKTSAEVMALTQQIVTANHLTTMMITHKMSDALTYGDRLVMVQDGQIKLDVCGAEKQALRTDDLVTMFAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD0</accession>
    <name>F9USD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890574.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3001"/>
    <dbReference type="EnsemblBacteria" id="CCC80060">
        <property type="protein sequence ID" value="CCC80060"/>
        <property type="gene ID" value="lp_3001"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3001"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2505"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287120_0_0_9"/>
    <dbReference type="OMA" id="IANADHG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2554-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394315" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="856"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="858"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1074" mass="114720" checksum="D1414F629981EA52" modified="2011-10-19" version="1">MIKPRVLTTLLVCSAILTTTVTPAVAAVTPMATPSEQVAEPVASPAVPTAILSLAIQNQQLVDLIGQTQWQTYGQPAVTKDPEFNDQVLNLDGKSAFYTTFTDQQFAKLQNGMAIEAYFKYDPAADANGEHEIFSSQQGGGLGLGVQNNQVVFFAHDGSGYKTPKGTLHKGQWVHAVGVIDKNKTASLYLDGQLVQQVAMPGDLKLAQGTKDFVLGGDAVPGSHVQSMMTGQIRQARLYDQTLTSQQVSQLNVEAQVGKQPVAPVPVDQTIATKLVGPKRIASGHTYGLNVHARQIKATGAAPITMDVVYDAAKFDYVGAERLLQGGKTQIQLIAPGRIRLTTTANLSKAEFKMYAQTRLAHLNLKAKAAGETQIKFEQLTKDTTIELGPAQTVEIQGKYALDYNGDGIIGVGDVALANAADKVAAAKAAEIKPYKHVVVLTTDGGGNPWDPKGMYYAQGAEQGTKTPVWTTNPEIMKKRRNTYTMDLFNKQFAMSTSARAVSPAISAQNYISMLHGRPWDTLPKEYQGTNATMGQEYFADFNKPQAMFPSVFKMLQADNPTRGAAAFSEWGPIVNSIIEPDAAVTTKQSASLKSFDDVANYIGTPEFQSTGLVYMQSDYMDGQGHGHGWYNDNYWDKYAQYDALFKRVMDKLEATGHIHDTLVIANADHGGSGKNHGGWDEYNRSIFMALGGETVDNGRRLHGGSNADISALILNALQVPQTPQMFDSQVFDSLAFLKQTDLSKKKRSVETLKLSRNDQEAKVQLTHNQNRQLTAFDLQLDLAGREVADVKVPTGVQILRQTVANGQLRLTVSASQPVTDLVTIELVPSKTRAAKTIMLSQAMAATADGTEVLVDLDNDNPLTSTAKPDENGSTTTKPDGNGTAVKPDENGSTTTKPDGNGTAVKPDENGSTTTKPDGNGTAVKPDENGSNTTKPGGNGTTVKPDKNGSSTTKPNGNGTAVKPDKHETSTTGSGTVNTSGADKTSTNDNGTSMTAGTASSHASTVTDRVTSGTVLPETSSSAATNHGSHSTGHHGSGWLPQTGEAVQRWLAVAGGVFLMLTGAIAVWWRKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH2</accession>
    <name>F9USH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular transglycosylase, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890616.1">
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    <dbReference type="eggNOG" id="COG1388">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394318" evidence="1">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="131" mass="15006" checksum="5FF852AB0B979268" modified="2011-10-19" version="1">MKKFNFKTMLLLVLASCVFGVVVNVTTSLGPQTAITAQASKKLSQAQQIAKINAKLSKANRAAKNWIAYRESGYSYTARNGRCYGRYQLLRSYLHGNLSPVNQEKRANTYVASRYGSWVKAKRFWQHHHWY</sequence>
</entry>
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        <name evidence="8" type="ordered locus">lp_3106</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
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        <property type="entry name" value="ABC_BtuC-like"/>
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        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
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        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="26"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="329"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCC80150.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="331" mass="34859" checksum="C2B577F8EF933186" modified="2011-10-19" version="1">MSPNRRLIIWSLLLTASMLGLAILNLSTGTMTISWPALLGILTSRGNATDMLVLVNFRLPRIVLAIMVGWALALSGNVLQTVTNNPMADPSLLGINNGAGLAVMLLIIGAGTNASLTLSLPIVALAGAWLSTALIFLLANQRQRGISSKRLLLVGVALSGCFSALMVLMTLKLSPDNYQFVMNWLAGSLWGTDWSYIGWALPWLAVGSGILFIQLPVLDAFTLGTTTAQTLGINLKRQQLGLISVAAMLAGVSVAISGGISFIGLITPNLARRIVGSRQRYQLPLAGLLGSTLLLAADTLGKLITTTTELPAGVLVALIGAPYFIYLLVRG</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="GDHRDH"/>
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        <source>
            <dbReference type="EMBL" id="CCC80155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="30203" checksum="61F31FE5E1FDA3F6" modified="2011-10-19" version="1">MQSKLAVIIGGTSGVGKHTAIDLANQNYHVIIVGSRADKGRQAQADISQATGNQAVQLALADLSTKTGVQQFAHQLAAMTDHIDILLNSIGVILPERHLSADGYDLNLVLNYLTHFWTIQALLPLLKHSDQARILLVGALPFVINHAKVSLPDFDAPATSKYNAMTVTAQATAARVLLTLALSERLTATNVTINIFHPGYVPDSNFGAGGSWVSRLAGRILGESFSRKNSPIGAWLATAPELTHTSGHFYDDRLRQVRLSKQYTRSKANDLWRLSSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP9</accession>
    <name>F9USP9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical membrane protein, DUF805 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642381.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890693.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3139"/>
    <dbReference type="EnsemblBacteria" id="CCC80179">
        <property type="protein sequence ID" value="CCC80179"/>
        <property type="gene ID" value="lp_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3139"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2627"/>
    <dbReference type="eggNOG" id="COG3152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648587_0_0_9"/>
    <dbReference type="OMA" id="EDQNTIT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2672-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="421" mass="47120" checksum="0AA720733C05EB96" modified="2011-10-19" version="1">MSETKYCINCGKAIPTNATFCPFCGATQDKVASTEDQNTITSEQHNTPNQPEHVNMWTALKLGMRQTFTWSQRITRPQYWWLYLDLVLISLVLTIVLGIRAYSYPAFILSPLHVNVLQTVLLLIFSALMVWTSVMQFTASARRLHDSNRSAHYLWFYLLPLVGPILIIVFLCQRSEPAGKRFDRLASQPKPWTHKWWTWCLLVLLTLGYAALINITARDTAMDAALTTTSKSATTNSDDSYSDSDSEESSDSTDYDSDSESDSDSITIGDDDIDIADQKAYSTSFTDSSWAKSTFKIDKVTVYKTDGTYTSGSGNDKKDFNGVVKVHMSIHAGQDISAYPTQAKLSTNDGQQVEADMDSDDFDGDLNSGTDSDGNLYFVLSKLSSVKDITSIRLKWDASYDTDDYDDDNAYKTFDTTLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU5</accession>
    <name>F9USU5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-beta hydrolase superfamily</fullName>
            <ecNumber evidence="4">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888190.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0122"/>
    <dbReference type="PeroxiBase" id="5460">
        <property type="entry name" value="LplHalNPrx01"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77676">
        <property type="protein sequence ID" value="CCC77676"/>
        <property type="gene ID" value="lp_0122"/>
    </dbReference>
    <dbReference type="GeneID" id="57026962"/>
    <dbReference type="KEGG" id="lpl:lp_0122"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.100"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_12_0_9"/>
    <dbReference type="OMA" id="ASWDMQR"/>
    <dbReference type="PhylomeDB" id="F9USU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-98-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="29040" checksum="AB4F39FEF281BFC6" modified="2011-10-19" version="1">MRFITSDHVQLDYTDEGQGQPIVILTGFGGAKDIWRAQIPVLIQAGYRVINLDGRCQGLSEHTAKGLRMSRRAVDAHELIEKLQLEQPILLGNSMGAATWFAYVSLYGDTGIKALIDVDQTPRMINTPHWQYGFKQVQWQDIPDYFRMPLGHSTFKHIDDATYARVKAVEAQAPFDAKLMFPLLVNHAVQDWRDVIRQLTVPFLIIAGAKSPFFNPDFAAVTAQMALRGQSVVIPEAGHIVMAEQSAAFNKALLEFLATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT03</accession>
    <name>F9UT03_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exo alfa-1,4-glucosidase or trehalase</fullName>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="4"/>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641787.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0193"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77734">
        <property type="protein sequence ID" value="CCC77734"/>
        <property type="gene ID" value="lp_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="57027021"/>
    <dbReference type="KEGG" id="lpl:lp_0193"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.159"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_9"/>
    <dbReference type="OMA" id="QAFNFQF"/>
    <dbReference type="PhylomeDB" id="F9UT03"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-156-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="13"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="557" mass="63343" checksum="B3C4A61E2977FE23" modified="2011-10-19" version="1">MANQWWQSAVVYQVYPRSFQDSNGDGIGDLPGITQRLDYIKQLGADVIWLNPIYRSPGVDNGYDISDYYDINPEFGTMADFDQLLTTAHAKGLKIMMDIVVNHSSDQNKWFTTSAQSKDNPYADYYIWRDPVDGHEPNNWGGFFGGSAWKYVASRDQYYLHSFAVEQPDLNWDNPQLRQAVYDMMNFWVNKGVDGFRLDVINLISKPDSFADGQPEAGEPYAAIGGIIANGPHLHEYLQEMNQQVFAGHQLMTVGETPGATVADAKQLASGQGQELNMVFEFEHMGLDGNPDPALGKWNDQPVRLVDLKQSLSKWQMGLQGTAWNSLYWNNHDQPRIVSRFGDERPAYRERSAKMLATLLHFLQGTPYIYEGEELGMTNAHFTKLTDYQDLESLNAYHHFVDDEQVVQPEQMLGYLAHMSRDNARTPMQWDDSQNAGFSTATPWLAVNANYPRINAQLAQRTPGSVLSYYQRLIKLRHHLPVITTGTYHLLSPDDAAVYAYVRHMGSQHLLVICNFTAATQTRHFAELPADAHLLISNYDEDHQDVLRAYEAKVYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT60</accession>
    <name>F9UT60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3">3.2.1.93</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">treA</name>
        <name evidence="3" type="ordered locus">lp_0263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.93" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0263"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77791">
        <property type="protein sequence ID" value="CCC77791"/>
        <property type="gene ID" value="lp_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0263"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.218"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="OMA" id="FYQIHPE"/>
    <dbReference type="PhylomeDB" id="F9UT60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-213-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008788">
        <property type="term" value="F:alpha,alpha-phosphotrehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012769">
        <property type="entry name" value="Trehalose_TreC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02403">
        <property type="entry name" value="trehalose_treC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="10"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="547" mass="62003" checksum="71400AA87E999C7B" modified="2011-10-19" version="1">MKLSEQVIYQIYPKSFYDSNGDGVGDLRGVIEKIDYLKKLNIDMIWFNPFFVSPQNDNGYDIADYYHIDPMFGTMADFEELVAKLKANGIGVMLDMVLNHTSTEHEWFQKALAGDEKYQKFYYLRPPKADGSLPTNWESKFGGPAWAPFGDTGLYYLHLYDPTQADLDWHNPAVRQACAAVVNFWRQKGVQGFRFDVINVTGKAEKLVDAPKGVPSKTLYTDTPVVHDYLKELNAASFGQDVNSVTVGEMSSTTVANSVGYTNPANHELSMVFNFHHLKTDYVDGRKWSRMAFDFPRLKQLLDSWASGMAAGGGWQALFWNNHDQPRALNRFGDAGRYRVKSAEMLATVIHLLRGTPFIYMGEELGMTDPDYDNMADYVDIEALNAYRALIRSGYSHHDAFTIVKTKARDNSRTPMQWDDSAKAGFTTGKPWLTPTNQATINVAHELASGEIFDYYQRLIKLRKTMPIVADGGYQSWRLDDPQVFGYWRTYRQQKLLVLNNFYGQSTTVTLPEEMVGAQVLLSNYQDVNVTAQLTMQPYQAVALLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA9</accession>
    <name>F9UTA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome partitioning protein, DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">parB2</name>
        <name evidence="9" type="ordered locus">lp_3200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642432.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTA9"/>
    <dbReference type="STRING" id="220668.lp_3200"/>
    <dbReference type="EnsemblBacteria" id="CCC80227">
        <property type="protein sequence ID" value="CCC80227"/>
        <property type="gene ID" value="lp_3200"/>
    </dbReference>
    <dbReference type="GeneID" id="57026489"/>
    <dbReference type="KEGG" id="lpl:lp_3200"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2675"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_9"/>
    <dbReference type="OMA" id="SQSYVAN"/>
    <dbReference type="PhylomeDB" id="F9UTA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2715-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023705">
        <property type="entry name" value="Nucleoid_occlusion_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04285">
        <property type="entry name" value="nucleoid_noc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="ParB" evidence="8">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="31690" checksum="CD1E9F15BFF14702" modified="2011-10-19" version="1">MAFSLFGSNRDKHKTEAATTPTEQQIVRIPVTAIIPNRFQPRQVFDETGIAELAATIADHGLLQPIVLREYEPQKYEIIAGERRFRAISSLHWADVPAIIQKMDDGETASMALIENLQRQDLTAIEEARAYQELMELNQLTQSALAKELGKSQSLVANKLRLLKLAQPVQTALLQRQISERHGRALLNLAVEQQAAVLKRVLADQLTVKETEQLVAKTQTPPKPKRKRARGLTGDTRIAVNTIKKSIKMVTDAGLPVKTHEEDTDDGYRITIEIPKNQPRGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC0</accession>
    <name>F9UTC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890752.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3216"/>
    <dbReference type="EnsemblBacteria" id="CCC80238">
        <property type="protein sequence ID" value="CCC80238"/>
        <property type="gene ID" value="lp_3216"/>
    </dbReference>
    <dbReference type="GeneID" id="57026501"/>
    <dbReference type="KEGG" id="lpl:lp_3216"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2686"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_9"/>
    <dbReference type="OMA" id="VSESTMY"/>
    <dbReference type="PhylomeDB" id="F9UTC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2726-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="105" mass="12063" checksum="68EBE2CA07BF6972" modified="2011-10-19" version="1">MAIQISSELLDGCVLACLKGQDYYGYALTQRLQAAISVSESTLYPVLRRLKKNDWVTTYDQAYQGRNRRYYQITSAGLTQLSAIQQEWQTYYLAINHLLQGEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC4</accession>
    <name>F9UTC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrose/trehalose-6-phosphate hydrolase,glycosyl hydrolase family 13</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890756.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3220"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80242">
        <property type="protein sequence ID" value="CCC80242"/>
        <property type="gene ID" value="lp_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3220"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2690"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_9"/>
    <dbReference type="OMA" id="FHYADID"/>
    <dbReference type="PhylomeDB" id="F9UTC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2730-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="13"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="555" mass="63948" checksum="0E97E153A157DD8D" modified="2011-10-19" version="1">MQKNWWQKEVFYQIYPASFKDANNDGIGDLRGIIQMLPRLKQLGITTIWLSPIYQSPMVDNGYDISDYQAIDSRFGTMADFDELMEVTKRLGLKVILDLVINHTSDQHVWFQSAIKSPTSPYRDFYIIRRGAHGNPPNNWRSNFGKGSSWTLLPGSQDEYYHHVFSKQQPDLNWENPALRKRIYQMINWWLAKGVAGFRIDAITFIKKDQDFASISPDGVDGLGKVKRKAENRPGIEKFLAELNTATFKPANAVTVGEASGVSYDQLGQFIGKKGYFSMIFDFHYADIDIASGSEWYRRVKWTPTDLRRAIFKSQLAIQNVGWGANFFENHDQPRSIDKYIQTPVYRNEIGAKALALLYFNLRGCPFIYQGQELGVTNARRDSITMFNDLSSHDNYDRAIEEGYSASEALAFVNARSRDNARLPYPWDDSVNQGFNQGAKPWITPKQSHDRVNWQSEQLDSNSVWHFYQSLIKLRQISNLSQDLIVGDFRPITCDCDQVIAYQRGRRVQVYVNLSAKRLLLTLPNGRPRLNNYAHYRLNTLEPYQAILFEVNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI4</accession>
    <name>F9UTI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Folylpolyglutamate synthase / dihydrofolate synthase</fullName>
            <ecNumber evidence="8">6.3.2.12</ecNumber>
            <ecNumber evidence="8">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">folC2</name>
        <name evidence="8" type="ordered locus">lp_3296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="8"/>
    <dbReference type="EC" id="6.3.2.17" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3296"/>
    <dbReference type="EnsemblBacteria" id="CCC80302">
        <property type="protein sequence ID" value="CCC80302"/>
        <property type="gene ID" value="lp_3296"/>
    </dbReference>
    <dbReference type="GeneID" id="57026564"/>
    <dbReference type="GeneID" id="66450830"/>
    <dbReference type="KEGG" id="lpl:lp_3296"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2752"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_9"/>
    <dbReference type="OMA" id="NLGWRIS"/>
    <dbReference type="PhylomeDB" id="F9UTI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2790-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="138"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="303"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="454" mass="49328" checksum="C2AC4B40F214F956" modified="2011-10-19" version="1">MDTGTIEQRYQDLLAQLNQAMLANNHQRVPLLRRIMAHLGHPDHYYHVIHIAGTNGKGSTGAMLASILRAQGYQVGRFSSPAINDAREQLQCNGTWISPAEFIDTYREILPVLQNMGLTASDVSIFEWFFLISVVWFRNQNVQWAVIEAGLGGLYDATNALASPQLTVFTKIALDHTAILGPTITAIAQNKSKIIKPHTTAVTLADQHPEALAVLQTEALNQGVRLVTAKHAQLTVTGQTLTQTVVDAHSQLFDWTQLTVGLSGTYQLQNLRLVLTVVAVLQQQQVNLTNSAVRRGLQQVSLPGRLTVLQEQPVIIADGAHNPDGMAALVASVKQLLAGRKLIWIVGVLQDKAYPKMLAELLPVADVLITNTPANPERALSATKLADTANALLTPTFMTTAAMQRQPDLLTATTITDALTQAQQQATSNSAIIVTGSFYVIRELQQAGWPGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL9</accession>
    <name>F9UTL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase (RNAP)-binding regulatory protein, arsenate reductase (ArsC) family, Spx subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spx4</name>
        <name evidence="4" type="ordered locus">lp_3345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3345"/>
    <dbReference type="EnsemblBacteria" id="CCC80337">
        <property type="protein sequence ID" value="CCC80337"/>
        <property type="gene ID" value="lp_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3345"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2789"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_9"/>
    <dbReference type="OMA" id="RMFIPRE"/>
    <dbReference type="PhylomeDB" id="F9UTL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2826-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="134" mass="15726" checksum="37BBB68B1BDF6BA7" modified="2011-10-19" version="1">MINLCVLPSTASCRKAHRWLLEHRIPFHERNMNAQPLTETEIKHLLQYTYNGIDDSISTKSNAYHQLSKTTPIEDMPLSEAVRVLSQTPQLLRRPIIFDDHRLLCGFNQDEIRMFIPREQRVLKMQAMSEHQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ0</accession>
    <name>F9UTQ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport protein, MMPL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0295"/>
    <dbReference type="EnsemblBacteria" id="CCC77820">
        <property type="protein sequence ID" value="CCC77820"/>
        <property type="gene ID" value="lp_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0295"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.248"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_0_0_9"/>
    <dbReference type="OMA" id="FMAVLGK"/>
    <dbReference type="PhylomeDB" id="F9UTQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-242-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1258"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="1227"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1377" mass="143317" checksum="5B1A6B5541340691" modified="2011-10-19" version="1">MKGSRRRFTIQAIVWLVVMVAAIIFLPNISSLVRDKGQTKLPSSAKSQVAQVIQNHWGRNQNNTRQVVVVFNNGDSPLTSDQKQAIDGTIQRFKVQKSKYHVKSMTAASDNAAAKKQLISKDKSTQLLQLMVGKNQTVANMTKNITAGAKTAGVKTYVTGSDILNDDFTQETEAGIQKTEIITVIFIFIVLTLVFRSPITPLVSLLSVGVSFIISLSVVMNLVNKFNFPLSNFTQVFMVVVLFGIGTDYNILLFDQFKEELSHGDSPVAATGRALKIAGRTILYSGSSLLIGFSALGLANFSIYKSAVGVAIAVAILLLVLLTLNPFFMALLGPRLFWPTKKFAGGSTSKMWHGIAASSVRYPIIALVVVLGVSLPFILTYNNELNYDTLAELNDTIPAKKGFQVVQDHFSKGTAEPSTLYIKTDHALNNEKDLKVIDSLTKQLQKVKGVKTVASVTQPGGSQIDQLYVGNQLGTVTSGMKSASKGLTKIGSGLDSANSKLKSANMSDSAKSAKKLADGADEVASGVVSYTDGVYTVNNGLNQLNSKTGTLSSGVNQLVSGSGQVTSGAKTVASGNSTLATNLVTYTNGVYTVNSGLNQLDSKTGTLSSGVNKLATGANSLSSGLTTVFSGTQSLSNGLSELNNKKTSISSGTTQLTTSISALQQGSATLSENLAALEKEVSSSNSAIDTSELQTLTDQLKKINTNLQTVADSPNNVSTNISSVEKAASAFSASNEDISNDMVTMKSALSSAASRDAASSSTTASVNANSVASAALAAAGSSATSEQKAAISSAVTSEVNAQNSSNASTSSTATTNAGTVTASDGLTALADMQQKLSTLKEASSSLDDLSSNLNNLASVQQVASAAIKGNQASLQAIQQISQAAAKMQQMEAAVAKLSSGSSELTNNLSKLQTGANTLATSLNQYTAGVATASAGASKLNTGVSSASTGASQLSSGLGSLQGQIPTLTSAISALDAGTNKLTNNSAALVSGANQLASGANQVASGSSQVTTGLTTLKGQVPTLVNAISALDAGTNKLVANSATLNSGASQVASGNEQMYTSIQSLVGQMQTLQDGLKTASDGTKTINTGVGSANSYLTGLKDSAAAKTYYVPKSTLKGKTYKSALKAYMSGNNHATKLTIVLNENPSSKSAMDKVTAIQKQATNSLKGTALDGATIAIGGQTSETNDTQAIASSDFVRTAAIMLVGILIALMVITRSVLQPFYILGTLLLAYIMSLSITRILSNWFLGQSMLTWNTPFFGFIMLIALGVDYSIFLMMKYREFDNSAATPSTRIVRASAVIGAVVLSAALILSGTFAALMPSGVLTLIQVAMVVIIGLIILVFAIPTIIPSLIRLTYPLTDRMEDETTAEKQTKRNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR9</accession>
    <name>F9UTR9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter,substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">potD</name>
        <name evidence="3" type="ordered locus">lp_0315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641891.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888353.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0315"/>
    <dbReference type="EnsemblBacteria" id="CCC77839">
        <property type="protein sequence ID" value="CCC77839"/>
        <property type="gene ID" value="lp_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0315"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.267"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_9"/>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="PhylomeDB" id="F9UTR9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-261-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394336" evidence="2">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="356" mass="40617" checksum="9DA8259E8C3A8F56" modified="2011-10-19" version="1">MKKLLSIIVSLLVVCGLLAFGAQRLQTSSGSTGKKVLNLYTWGDYIDPSLLTKFQKQTGYHVNVETFDSNEAMYTKIKQGGTSYDLTVPSDYMIEKMKKAHLLLPLDKSKLTGMKNYDPRFMNLAFDQHNRYSVPYFWGTLGIIYNDKYVQPGSIQHWNDLWQRKYHNKIMLIDSARDVMGFALASMNQSMNTTDPATLLAARNKLNRLSPNVKAVVADEIKMYMIQNEAAIAVDWSGEASEMLAGNSHLHYVVPSEGSNLWFDNLVIPKTAKHFKAIYAFLNFMSEPKNAAQNAEYIGYATPNRKAKALLPKAIRNDRQFYPDNNTIKHLQIYQDLSPAKVGLYNDRYLEFKMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV4</accession>
    <name>F9UTV4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1304 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0357"/>
    <dbReference type="EnsemblBacteria" id="CCC77874">
        <property type="protein sequence ID" value="CCC77874"/>
        <property type="gene ID" value="lp_0357"/>
    </dbReference>
    <dbReference type="GeneID" id="57027165"/>
    <dbReference type="GeneID" id="66448449"/>
    <dbReference type="KEGG" id="lpl:lp_0357"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.301"/>
    <dbReference type="eggNOG" id="COG3759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129819_0_0_9"/>
    <dbReference type="OMA" id="LEMFLWE"/>
    <dbReference type="PhylomeDB" id="F9UTV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-296-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="PTHR38446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13145" checksum="6CC371777B4667BD" modified="2011-10-19" version="1">MHVAAMIMAILVAVEHLFILWLEMFNADSEMAAKAFGIPRQTLQSPSVQLLFKNQGLYNGFLAVGILYSLFVIPAVASAGATLFFLACVMVAAVYGSITVSRAIVVIQGLPALIAFILMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW5</accession>
    <name>F9UTW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine betaine/carnitine/choline ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">choQ</name>
        <name evidence="5" type="ordered locus">lp_0368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888399.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0368"/>
    <dbReference type="EnsemblBacteria" id="CCC77885">
        <property type="protein sequence ID" value="CCC77885"/>
        <property type="gene ID" value="lp_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0368"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.312"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_5_9"/>
    <dbReference type="OMA" id="DKICIMN"/>
    <dbReference type="PhylomeDB" id="F9UTW5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-307-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35857" checksum="D7A7C10AEEB5A394" modified="2011-10-19" version="1">MTTAIEFQHVQKDFNGQTVIPDLNLTIDQGELFVLVGTSGSGKTTSLKMINCLEPLTAGKILVNGTDTTTIPVRSLRWQMGYVLQQIALFPTMTVAQNIAVIPEMKGTAKKEINQTIDELLAEVGLDPKEYRDRMPSELSGGEQQRIGILRAIAAQPDIVLMDEPFSALDPISRQQLQDLVLRLHARYHNTIVFVTHDMNEALKLGDRIGVMQHGQLIQVDTPAALAQHPVNDFVRNFFGASRAKNVYDVYVGRVGLIQGYLTEEPSVASGRIQSLDVQATLRTAFTALTDHDYVAVTEENRVVGYLDRQRIVAYLSQHEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU28</accession>
    <name>F9UU28_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dus1</name>
        <name evidence="9" type="ordered locus">lp_0443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101007.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888462.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0443"/>
    <dbReference type="EnsemblBacteria" id="CCC77948">
        <property type="protein sequence ID" value="CCC77948"/>
        <property type="gene ID" value="lp_0443"/>
    </dbReference>
    <dbReference type="GeneID" id="66448521"/>
    <dbReference type="KEGG" id="lpl:lp_0443"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.363"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_9"/>
    <dbReference type="OMA" id="YRPPAHW"/>
    <dbReference type="PhylomeDB" id="F9UU28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-369-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="37155" checksum="B6675D41D55A279D" modified="2011-10-19" version="1">MTATPFWSQIAAQAKADGRPFFTMAPMEAVSNTVFRQVISHAAAPDTFFSEFVYAKSITNPNTKFPVHGRLYVAAAESQKPVVQLWGNEAADFASATAELRDRGFEAVDINMGCPDGTVIKNHGGSDLIRNPQWAEDVIAAAKTSGLAVSAKTRLGYSKVAEYHDWIATLLSQHVAVLTVHLRTKQEMSKVPAHFEVIDDLIKMRDAIAPETLLQINGDVADYQAGVALAKAHPGLDGIMIGRGVFANPFAFESQPQSHDLHELLGLLNMQLDLFDDFATRYDVPRFPSLKRFFKIYARPELGATDLRNTMMDAKSTDDVRKILAAYQAKMRVTNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU51</accession>
    <name>F9UU51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890867.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3366"/>
    <dbReference type="EnsemblBacteria" id="CCC80353">
        <property type="protein sequence ID" value="CCC80353"/>
        <property type="gene ID" value="lp_3366"/>
    </dbReference>
    <dbReference type="GeneID" id="57026616"/>
    <dbReference type="GeneID" id="66450880"/>
    <dbReference type="KEGG" id="lpl:lp_3366"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2806"/>
    <dbReference type="eggNOG" id="ENOG5030ACG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2437144_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2842-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="9858" checksum="973F01DE586708A5" modified="2011-10-19" version="1">MSTQSQITQTQVLDAISRAALMLERQDAAQSGLQLLLNEFRRSLLQTSGQAATTVLYHGKIKSYLLQHPSNYPDSVAALSSLLDHFVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU91</accession>
    <name>F9UU91_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890907.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3412"/>
    <dbReference type="EnsemblBacteria" id="CCC80393">
        <property type="protein sequence ID" value="CCC80393"/>
        <property type="gene ID" value="lp_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3412"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2842"/>
    <dbReference type="eggNOG" id="ENOG5030ATD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278462_0_0_9"/>
    <dbReference type="OMA" id="HTRNNTA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2880-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388166" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1136" mass="118729" checksum="4DC5A438676A21F7" modified="2011-10-19" version="1">MMVLLQVIAAGATVSLGADMTAQAATLPQLTFAKSTASDNILTNQHFDVELQVGDTASKINTIDLPNEVNLDGPEEFKQIKRVFDDSQYTTGDNGAFTITAKHLTVAYNPDKRRITVQWSDEYPQTKVPIRLTAVKAEKLALVAVADDQKGPALNVEIKQPQTQADQASTSSASSSAATDTNSSTASSSRQATSSAASLDSSRSAATTLSSQAVNQTSASSSEPSQETAANQSSAVTESAGETTDSSASISSSSTASQVFSSAPTKQATASAKSSPLIPVTRLAQLSSNVVDVSQWSQLVDAWKDASVDEINITADISNPTAASGALDSRLSGNIIVNGNGHSVNIGRAGFHTRNNTATSGTMYTATFMNFASLIGSFGNDAGLIGSSTGGDGAGGALNWTFNVSNITVPSGTSYTNTSRRFVSAQGNQVNITGNCRVTTVRENILCGGLDVAAGQTFTGSKIANGDDNSFIWFVYDYQGTGNRQVNVEEGATLNCIRRPASSTSTAYTTYPVIFDAYESINVGKNATFNASVPGNAYSNKYFYGSQYHRNFYADTGSTVNLTSLARSQSPISFSDNATSTIQSSSGANIYVIAATGAPLISGNYARLATVRFINPNNLDLRNSSTGTTAAASSINQDNVGTFEIQDSNISLWKLASSVTGGADYSYSNVSQLLQQGSAVTATDSNLQSNYLSSKMRRISATNQKPQLAFNNPYDGTTKLTDADQKLRTRVIVAMVPDTNGVQDDGTVNYIPQYASAGQLTVSYSVNGKTITAQTDSNGYATANVGTFLKAGTTVTASTSNTSGTTVTATGTVVDVTPPNPATMVSPDPIRVSTGTVSGQNGEPGAQVTLALNGQIQTNVKTVVNANGTWSLNLTGLSLKIGDKIIIYMADSLGNRNPDPNSYPNGQQYHDATFQPAPIFTVAKDLIVNPIDPDDPSKPGTGGTNNLGPLSLDAVPTHLNFGQHSIPTMDTAYPLLSPSAAEDQLATATDGQKYATVGGQKNGQDSVYTQVTDTRDTPSGWQLTAQLSALTATDGTTMTGSYVTLTSGTAQYLNASTSKWVTATDQNQATLPAVIKLTPGATQQTLIAGTTSQQGVGTNQQIWNVNNVALHVKGGRVMAKNYSGTITWQLNSLPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC1</accession>
    <name>F9UUC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102167.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890937.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80423">
        <property type="protein sequence ID" value="CCC80423"/>
        <property type="gene ID" value="lp_3448"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3448"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2871"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_30_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2911-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17962" checksum="875EA092B7D8FDC1" modified="2011-10-19" version="1">MSQFEKYHPILTPHYTFDWLTKVRVIDVFNLYQTSNATATMETTAAQINHTMREIFHDHQLVWGVTARDTNAFVGQVGFAPIDTAKHEATLSVDLTATYQQVTTLREILERLVAFGTVELKLNRLTLILPKHDDLMAQILAGLNFSTTDHLTFNYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH1</accession>
    <name>F9UUH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase (Promiscuous)</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estA</name>
        <name evidence="2" type="ordered locus">lp_3505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="gene ID" value="lp_3505"/>
    </dbReference>
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    <dbReference type="GeneID" id="66450965"/>
    <dbReference type="KEGG" id="lpl:lp_3505"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2961-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
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    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="30140" checksum="AD1B01E23D1640EE" modified="2011-10-19" version="1">MSIHSNNFYSNVLRQSVQVQVILPEPVNAVGQILPDYSSGEQQLPTVWLLHGLGGDATSWLRRTEIELLATQYRVAVVMPETGRGFYTNMVHGPRYWDYLTHELPTRMRYIFPLSARPEDNYLLGNSMGGYGALRYAFTYPQRFAAVAALSPVTDLKRFHVEQSAIMPDLELAFSPAQMQGTPADLSYLVQQPTNWGTLRVLMATGDQDMLRSMDEAFKPELAAVFKDQFEWQLQPGHHDWRLWNHQLPFAMHWLIKGGWRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH8</accession>
    <name>F9UUH8_LACPL</name>
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        <submittedName>
            <fullName evidence="16">PTS system, beta-glucosides-specific EIIBCA component</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts30BCA</name>
        <name evidence="16" type="ordered locus">lp_3513</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890994.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3513"/>
    <dbReference type="EnsemblBacteria" id="CCC80480">
        <property type="protein sequence ID" value="CCC80480"/>
        <property type="gene ID" value="lp_3513"/>
    </dbReference>
    <dbReference type="GeneID" id="57026725"/>
    <dbReference type="KEGG" id="lpl:lp_3513"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2928"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_1_9"/>
    <dbReference type="OMA" id="QIWYAAG"/>
    <dbReference type="PhylomeDB" id="F9UUH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2968-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="110"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="484"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="624" mass="66057" checksum="54FFAB776D75E558" modified="2011-10-19" version="1">MDYSELAQSILTNIGGKDNISKAWHCATRLRFNLKSTDKANTEAIENLDGVITVVQSAGQYQVVIGNAVAQVFAVLADLAGLANPDTAADAATTTEDTGEKQNIINRFIAFISGIFTPFLGALAGAGILKGLLALAVAFNLMSTTSGAYKIWYSAGDAIFYFLPVFLAFTAAKQLKVNQFVAVSLGAALLYPTLVTVMTNSTTLHFFGIPVVPTTYTSTVIPILLAVWVLSYLEPVLDKLFPAAIRNIFTPLFSLIIMVPLTLLVVGPIGGLIGNGLASGVMAIYNFMPIGAGVIMGAFWQVFVIFGVHWTFVPLMMNNIAKMGYDPLLPILSAAVLSQAGAALAVFLKSRDQKMKALAGSSFVTALFGITEPTIYGVTLKLKRPFYCAVVGGALGGAIIGAAGTHASSFTLPSLLAVPTFLGHGFMGEVIGLIVAFLGGAILTYFFGFARQQQADYSVVSDQSDNTVMAPVEGTIIPLTSVHDEVFASEAMGKGLAIVPNKGTVTAPVDGTITAVYPTGHAIGITANSGAEILIHIGINTVQLNGQYFETMVKQNQVVKRGDLLTKFDVDKIKTAGYDTTVMVIITNTADYQMVKPTDATETSDNWILELQPKEIMEGAPANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI6</accession>
    <name>F9UUI6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system sucrose-specific EIIBC component</fullName>
            <ecNumber evidence="15">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pts32BC</name>
        <name evidence="15" type="ordered locus">lp_3522</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="15"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102202.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3522"/>
    <dbReference type="EnsemblBacteria" id="CCC80488">
        <property type="protein sequence ID" value="CCC80488"/>
        <property type="gene ID" value="lp_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3522"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2936"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_012312_2_0_9"/>
    <dbReference type="OMA" id="VAHCMTR"/>
    <dbReference type="PhylomeDB" id="F9UUI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2976-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="140"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="498" mass="51904" checksum="7E5DEBCF0318FC70" modified="2011-10-19" version="1">MAEDKYTRIANAIYAHVGGPQNIEKLIHCMTRVRMTIRDYSLVDMDGLKAIDGVMGVVQEDTLQVIVGPGTVDKVADVMVKQVGVGLGEPFPDPSTFTSDAMATKSEHQRDKEMVEAKAKEVHAAQKAKIKQTPVRKVLSAISSIFIPLIPVFVGAGLISGIASILSNMMLAGDISKSWTDFITVLKVINSGLFSYLVIYVGINSATVFGATAGLGGVIGAVTLLTGVTPQAPIHNIFNGQALSAGQGGIIGVIFAVWVLAIVEKWLHKVIPDSIDIIITPTIALLVVGVFTIFLVMPIAGVISNSLVGAIEWILNVGGAISGFVLGLLFLPMVMFGLHQILTPIHIEMINKLGMTPLLPILAMAGAGQVGAALALWIRCRNNKQLSNMIKGALPVGVLGVGEPLIYGVTLPLGRPFITACIGGGIGGAVIGGLGNIGATAIGPSGVALIPLIANGHWLGYVIGLLAAYAGGFVATYFFGIPSSAKIAKDKEGHVIEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>P59617</accession>
    <accession>F9UM00</accession>
    <name>ARLY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name type="ordered locus">lp_0776</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101154.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888753.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59617"/>
    <dbReference type="SMR" id="P59617"/>
    <dbReference type="STRING" id="220668.lp_0776"/>
    <dbReference type="PRIDE" id="P59617"/>
    <dbReference type="EnsemblBacteria" id="CCC78239">
        <property type="protein sequence ID" value="CCC78239"/>
        <property type="gene ID" value="lp_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0776"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.656"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_9"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="PhylomeDB" id="P59617"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-674-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137781" description="Argininosuccinate lyase">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <sequence length="467" mass="52270" checksum="7D2703BE9075820A" modified="2003-04-23" version="1">MSTQKLWGGRFTETGAKYVDDFGASISFDQLLAAEDIAGSLAHVKMLKKTGILPAADVDQIVAGLETLAERQKQGELEFSTVNEDIHMNIESLLTEEIGPVAGKLHTARSRNDQVATDFHLYLKHQLPLILDRLHELETVLVDKASENVETVMPGYTHLQHAQPISYAHYLLAYYQMFKRDMERFEFNLKHTDISPLGAAALAGTTFPIDREYSAKLLGFSEVYHNSLDAVSDRDFVLEFLSNASILMMHLSRFCEEIVSWSSYEFKYISLSDQFSTGSSIMPQKKNPDMAELIRGKSGRVYGNLMGLLTVMKGIPLAYNKDLQEDKEGAFDTVTTVLTSLHVFTGMLATLTVNEDRMADATTNDFSNATELADYLANKGIPFREAHAIVGKLVLDGLKKQRPLQDIPLKEYQSISPLIQEDVYHDLNAKVAVERRHSLGGTGFDQIRQELQRAQTQLSAYQSETTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF9</accession>
    <name>Q6LWF9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cadD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222025.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133732.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723568"/>
    <dbReference type="EnsemblBacteria" id="CAG17849">
        <property type="protein sequence ID" value="CAG17849"/>
        <property type="gene ID" value="CAG17849"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17849"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3096"/>
    <dbReference type="eggNOG" id="COG4300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071117_1_1_9"/>
    <dbReference type="OMA" id="MNGGDNI"/>
    <dbReference type="PhylomeDB" id="Q6LWF9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3149-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004676">
        <property type="entry name" value="Cd-R_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03596">
        <property type="entry name" value="Cad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00779">
        <property type="entry name" value="cad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="204" mass="23260" checksum="9D3B99551B2194E4" modified="2004-07-05" version="1">MIRTIITSIILYTSTAIDLLVILMLLFSKYRSTKHRRQIYIGQFLGSYTLIGISLFFAFILHYVPAKWLLGFLGLIPIAFGIKYIFSKEDEAAEVDQKIEARKNKNLIATVALITVASCGADNIGLFVPYFVSLSLVQLIVTLFVFTICVYFLVFLGDKFSQVNFVKNFLDRFGDWIMAIIYIGLGIMIILESDTIRHIMQLLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S50</accession>
    <accession>F9ULE8</accession>
    <name>RHAM_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
            <ecNumber evidence="1">5.1.3.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rhamnose 1-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type-3 mutarotase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaM</name>
        <name type="ordered locus">lp_3594</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the anomeric conversion of L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-L-rhamnose = beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:25584"/>
            <dbReference type="ChEBI" id="CHEBI:27586"/>
            <dbReference type="ChEBI" id="CHEBI:27907"/>
            <dbReference type="EC" id="5.1.3.32"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; L-rhamnose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the rhamnose mutarotase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.32" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S50"/>
    <dbReference type="SMR" id="Q88S50"/>
    <dbReference type="STRING" id="220668.lp_3594"/>
    <dbReference type="EnsemblBacteria" id="CCC80555">
        <property type="protein sequence ID" value="CCC80555"/>
        <property type="gene ID" value="lp_3594"/>
    </dbReference>
    <dbReference type="GeneID" id="57026788"/>
    <dbReference type="GeneID" id="66451028"/>
    <dbReference type="KEGG" id="lpl:lp_3594"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2999"/>
    <dbReference type="eggNOG" id="COG3254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_2_0_9"/>
    <dbReference type="OMA" id="KRHDEIW"/>
    <dbReference type="PhylomeDB" id="Q88S50"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3042-MON"/>
    <dbReference type="UniPathway" id="UPA00125"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062192">
        <property type="term" value="F:L-rhamnose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01663">
        <property type="entry name" value="L_rham_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013448">
        <property type="entry name" value="L-rhamnose_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02625">
        <property type="entry name" value="YiiL_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="chain" id="PRO_0000344582" description="L-rhamnose mutarotase">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01663"/>
        </source>
    </evidence>
    <sequence length="104" mass="12320" checksum="F7AC5B5143719328" modified="2003-06-01" version="1">MVRLGQVMYLHKDAYEEYAKRHAELWPEMKTALKKYGATNYSIFLNKLTGQTFAYLEVPDEATYNEIAETDICKKWWKYMEPLMDTNEDNSPVTTDLQEVFHLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SR1</accession>
    <accession>F9UTK9</accession>
    <name>ADEC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">Adenase</shortName>
            <shortName evidence="1">Adenine aminase</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ade</name>
        <name type="synonym">adeC</name>
        <name type="ordered locus">lp_3334</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890841.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SR1"/>
    <dbReference type="SMR" id="Q88SR1"/>
    <dbReference type="STRING" id="220668.lp_3334"/>
    <dbReference type="DNASU" id="1063932"/>
    <dbReference type="EnsemblBacteria" id="CCC80327">
        <property type="protein sequence ID" value="CCC80327"/>
        <property type="gene ID" value="lp_3334"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3334"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2779"/>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_9"/>
    <dbReference type="OMA" id="TDHECFT"/>
    <dbReference type="PhylomeDB" id="Q88SR1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2817-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142426" description="Adenine deaminase">
        <location>
            <begin position="1"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <sequence length="563" mass="60927" checksum="A4B5159C11718FA7" modified="2003-06-01" version="1">MTKTVEMVITGAQVLNVYTREFEATSLWIDHGRIISNLRDEPYIAAQHVDATGQWIVPGMIDAHVHMESSMVAPSELGKVLLQHGVTTIATDPHELANVAGIAGIQYLIDDARQTPLDVCFMLPSSVPCVPFDDNGATLHAADLRPLYQQSEVRGLAEVMDYGAVARGDTDTLAKISDAYAYGYHADGHAAGLNAHQLNVMRNAGLDTDHECMTVAEAQDRVRAGMAVFLREGTVERDVLPTIGAVTEANASRFAFCTDDKMISDLLTEGSIDYNVRLAMQSGMRPELAYTLASLNGAMAHRLSDRGSLSAGQLADLVVLDDLEHVRIARTMKRGQWILPSTTKPLPFTATRVQHHAQLADFQLPLATGLANVIGVQPNHIETDHLTLPIDATQNFEADCQRDILKMVVIERHHNTGKVGVGLVHGFALKQGAIAGTVAHDAHNIVAVGTSDAAILRAVAQITQDNGGIAVVDNEQVLATMPLAIGGLLSAASYQKVAEQLAELKRAYEVISERPLSFDPFITLSFLTLPVIPTLKLTARGLFDYATFDFIPVAIQDNQRQTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE6</accession>
    <accession>F9UR68</accession>
    <name>HIS8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisC</name>
        <name type="ordered locus">lp_2551</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101825.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE6"/>
    <dbReference type="SMR" id="Q88UE6"/>
    <dbReference type="STRING" id="220668.lp_2551"/>
    <dbReference type="DNASU" id="1062746"/>
    <dbReference type="EnsemblBacteria" id="CCC79707">
        <property type="protein sequence ID" value="CCC79707"/>
        <property type="gene ID" value="lp_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2551"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2143"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_9"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="PhylomeDB" id="Q88UE6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2199-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000153375" description="Histidinol-phosphate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <sequence length="356" mass="39431" checksum="6CD0EDCE25860119" modified="2003-06-01" version="1">MKASIEQLEPYVPEKPLATLQAELGLTELVRLSANENPYGTSPKVATAVKNWDFTQSNRYPDADAQELRQAVAQQQGIDPNSIVFSVGLDEMIVMLSRTFLATNDQVLVSAPTFSEYGLHAEIEGGQLISVPTLPNDHVNFEGLMKAITPHVKMVWLCNPNNPTGTVESLAAIEAFVQQVPPETMVLIDEAYIDFTPGAAQVTAMQLPAKYPNVVVMRTFSKAYGLANFRIGYAVFNTKYAATMQTIRLPYNVNSLAQVAALAAIDDPNFVKQTVQKNATERAKWMAFFDDQGVTYDQSGANFIFFKYPSATQLADYLVHHGYLIRTGLRPGWLRLTVGTANDNQQLQQLIREFKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VL8</accession>
    <accession>F9UPY6</accession>
    <name>HRCA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hrcA</name>
        <name type="ordered locus">lp_2029</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640713.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889789.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VL8"/>
    <dbReference type="SMR" id="Q88VL8"/>
    <dbReference type="STRING" id="220668.lp_2029"/>
    <dbReference type="EnsemblBacteria" id="CCC79275">
        <property type="protein sequence ID" value="CCC79275"/>
        <property type="gene ID" value="lp_2029"/>
    </dbReference>
    <dbReference type="GeneID" id="57025581"/>
    <dbReference type="KEGG" id="lpl:lp_2029"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1714"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_9"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="PhylomeDB" id="Q88VL8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1736-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000182489" description="Heat-inducible transcription repressor HrcA">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <sequence length="347" mass="38909" checksum="FD9420DF820CDF57" modified="2003-06-01" version="1">MITLTERQSLILKAIVRDYTEGGNPVGSKSLVQELPIKVSSATIRNEMARLEDLGLIVKTHLSSGRIPSIKGYRYYVDHILKPEKVDGKDLKVIQHSLGGEFHKIDEIVAQSADILSQLTSYTTFTLRPELKDSRLSGFRLVPLGNHQVMAILVTNNGDVENQTFTIPSDITGDELEPVVRFIDDQLVGLPLQDVLRQLTHEIPLKLAQYLQDPDGFLDIFGSVLSKAASERFYVGGKLNLFNYTDQQSPKELQSLYSLLDQTDRLANVIGPPGQRIQVRIGNEITNDLLKNYSLITATYDVDQHGQGVIALLGPTAMPYSRMIGLMGAFQRELARKLLDYYRYFDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W20</accession>
    <accession>F9UPI5</accession>
    <name>RNH2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">lp_1853</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645025.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W20"/>
    <dbReference type="SMR" id="Q88W20"/>
    <dbReference type="STRING" id="220668.lp_1853"/>
    <dbReference type="EnsemblBacteria" id="CCC79124">
        <property type="protein sequence ID" value="CCC79124"/>
        <property type="gene ID" value="lp_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1853"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1561"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_2_1_9"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="PhylomeDB" id="Q88W20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1587-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000111585" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="255" mass="27920" checksum="DA955C88DE9777FE" modified="2003-06-01" version="1">MPERTIADFKRLLADQPTASLLAAAQADPRKGVQQAYQHYLRQAEKQAVLVTRFNQHMRLERDFWAHGGQYVAGIDEVGRGPLAGPVVTAAVVLDDHFDLLEVNDSKQLTAKKRAALMPRILEEAVAVGIGVADAQQIDQLNIYEATRVAMAQAVRNLSVRPTRLLVDAMQVPVPIEQTRLIKGDAKSASISAASIVAKVVRDHLMTMYDQVYPGYDFADNMGYGTAKHLAGLASLGATPIHRQSFSPVRNAKRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W26</accession>
    <accession>F9UPH9</accession>
    <name>HSLU_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslU</name>
        <name type="ordered locus">lp_1845</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640560.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889632.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W26"/>
    <dbReference type="SMR" id="Q88W26"/>
    <dbReference type="STRING" id="220668.lp_1845"/>
    <dbReference type="EnsemblBacteria" id="CCC79118">
        <property type="protein sequence ID" value="CCC79118"/>
        <property type="gene ID" value="lp_1845"/>
    </dbReference>
    <dbReference type="GeneID" id="57025434"/>
    <dbReference type="KEGG" id="lpl:lp_1845"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1555"/>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_9"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="PhylomeDB" id="Q88W26"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1581-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000160514" description="ATP-dependent protease ATPase subunit HslU">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <sequence length="472" mass="52615" checksum="E022C6B60A543780" modified="2003-06-16" version="1">MEEINKTPKQIVAALDNYVIGQNQAKKAVAIALRNRYRRMELSAEMQEEITPKNMLMIGPTGVGKTEIARRLAKIVHAPFVKVEATKFTEVGYVGRDVESMVRDLVDVAIEMEKQQAYSGVRAQAVQAADKRLVKLLVPAQKKQAKNNGNEFQNMMNMFSQMQNGQTPNVDDSSNEEVTDEVRNQRLSVADQLKTGRLENSEVTIEMDDPQQAAAGNNNMLGQMGIDLGDSLGALMPKKRIQRTMPVSEAREILVREESEKLVNNADIYHDAIVRAENTGIIFIDEIDKITKGGQQGSGEVSREGVQRDILPIVEGSQISTKYGPINTDHILFIASGAFAESKPSDLIAELQGRFPIRVELDDLSKDDFVKILTEPKNALIKQYIALIGTDNIKVTFTIEAIEAIATIAYKVNHETQNIGARRLHTILEKLLEELLYEGPDMEMGEVTITESYVNERIGNIAQDKDLSRYIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W97</accession>
    <accession>F9UPA6</accession>
    <name>RECU_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction resolvase RecU</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein U homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recU</name>
        <name type="ordered locus">lp_1752</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecU family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644374.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889559.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W97"/>
    <dbReference type="SMR" id="Q88W97"/>
    <dbReference type="STRING" id="220668.lp_1752"/>
    <dbReference type="EnsemblBacteria" id="CCC79045">
        <property type="protein sequence ID" value="CCC79045"/>
        <property type="gene ID" value="lp_1752"/>
    </dbReference>
    <dbReference type="GeneID" id="57025373"/>
    <dbReference type="GeneID" id="66449608"/>
    <dbReference type="KEGG" id="lpl:lp_1752"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1478"/>
    <dbReference type="eggNOG" id="COG3331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096340_0_0_9"/>
    <dbReference type="OMA" id="TDYNGIY"/>
    <dbReference type="PhylomeDB" id="Q88W97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1508-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00130">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004612">
        <property type="entry name" value="Resolv_RecU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03838">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037785">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00648">
        <property type="entry name" value="recU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212298" description="Holliday junction resolvase RecU">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="207" mass="23754" checksum="573DBCA554837244" modified="2003-06-01" version="1">MTIRYPNGQVYRQPGPTKSKSSKFANVNFGDRGMSLEQEINDSNAYYLENNIAVIHKKPTPIQIVKVDYPKRSAAVIREAYFKQASTTDYNGVYRGKYLDFEAKETKNKTAFPLKNFHEHQIKHMRQCLAQSGICFVIIRFASLGRLFLLTASDLFTYWDHQGDGGRKSIPLTDIEHLAAELHYQINPRIPYLDALDHIIDETSSIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ1</accession>
    <accession>F9UP12</accession>
    <name>RL19_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">lp_1640</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889465.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ1"/>
    <dbReference type="SMR" id="Q88WJ1"/>
    <dbReference type="STRING" id="220668.lp_1640"/>
    <dbReference type="PRIDE" id="Q88WJ1"/>
    <dbReference type="EnsemblBacteria" id="CCC78951">
        <property type="protein sequence ID" value="CCC78951"/>
        <property type="gene ID" value="lp_1640"/>
    </dbReference>
    <dbReference type="GeneID" id="57025222"/>
    <dbReference type="GeneID" id="66449521"/>
    <dbReference type="KEGG" id="lpl:lp_1640"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1387"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_9"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="PhylomeDB" id="Q88WJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1414-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000163470" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="118" mass="13610" checksum="8EA5EDA0A4B8A85F" modified="2003-06-01" version="1">MRQNQLIEKITNEQLRTDIPDFRAGDTVRVHARVVEGTRERIQLFEGVVIKRHGSGISETYTVRKISNGVGVERTFPLHTPRVAAIDVVRQGRVRRAKLYYLRNLHGKAARIPERRRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ9</accession>
    <accession>F9UP04</accession>
    <name>SMC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smc</name>
        <name type="ordered locus">lp_1632</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889457.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ9"/>
    <dbReference type="SMR" id="Q88WJ9"/>
    <dbReference type="STRING" id="220668.lp_1632"/>
    <dbReference type="PRIDE" id="Q88WJ9"/>
    <dbReference type="EnsemblBacteria" id="CCC78943">
        <property type="protein sequence ID" value="CCC78943"/>
        <property type="gene ID" value="lp_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1632"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1379"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_9"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="PhylomeDB" id="Q88WJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1406-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000409275" description="Chromosome partition protein Smc">
        <location>
            <begin position="1"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge">
        <location>
            <begin position="519"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131883" checksum="D291DAE0382FEF3E" modified="2003-06-01" version="1">MQLKSLEISGFKSFADKTKIDFQAGMTGIVGPNGSGKSNIIEAIRWVLGEQAVKSLRGTKMTDVIFAGSANRKPLNMAKVTITFDNSDHFLPLDYAEVSITRKLFRNGDSDYLINNQSCRLKDITNLMIDTGLGKDSFSVISQGRVEAVFNAKPEERRSIIEDVAGVLKYKKDKFTTENKLAETTDYLDRVNDIIAELNQQKGPLEEQASLARDYQDQKQKFDYLDRSRLVKKLTIARDQLQGVNEKLASAKALVAKYQQQVDAGATKLANLKTQQTAQLKQKDELVAQNLELIKTIENTQGQQGVDAERRQNQQSEQERLTASLTATEQQIATQTEQQTQLEQTLSEQQAQVKAVKAQVAELTTATSAAGRQQLADELEKLRNAYIDEKQVQAELNNEAKNLVKQHQQSGSQSTALAERLAQAQANLKRVQTTVDVHNREQRDLENQVSQQQATLTAQQAQVKTNAERIDEQQQRWLDAAGLMQREKSRLEALQAVQERYTNFYAGVRMVLQHRQQFSGVAGAVSELLTVPDQYTKAVEVALGGQLQNIVCDTQQTAKTVVNFLKQNHAGRATFLPIERITARQLPVNTERDLSQQPGVLGVASELVDCESRLTAIKRYLLGTTAIVDTLDHAMAISRSRRFRCKLVTIDGETIAASGAITGGATRHDDNGLLQQQQSAEKIAANVAQMQSELVTYEQGLADLKKANQDLTVQVETTRQQLSELKDRLSQTQAQLQAAQSEQTQLSRQVKALTYEQQQTQADDSYEDLVARNQQAQAANAAKLKDYQDQMKTVQQQQTDYESYQQTQTTKLQAQREQLITLQEHVKQTQRQLEQCQATLAQNEETKKQIQADLTAIKTTLASQQMSVAERDTVLKTAKAKQAAVEEQRKTCEQQLATLNDQVEELSTQQVRLQQLAAAATDDYRRLELSQTKLTGEVDHATADLAEKYQLTVAAAQADVSGLALPAITEQLKLLKRGLDEIGTVNLGAIDEFERVKERFDFLNNQASDLTEAKEHLLQTMADLDTTVATRFKTAFDQVASEFSTIFEQMFGGGKAELILTDPEHLLTSGVDIMAQPPGKKFQRLSLLSGGERALTAITLLFAILAVRPVPFSILDEAEAALDDANVDRFSQYLNDFQTGTQFVIITHRKGTMMHADVLYGVTMEESGVSKMVSVSLADLKDEQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WM8</accession>
    <accession>F9UNX4</accession>
    <name>FOLD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">lp_1599</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645162.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889427.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WM8"/>
    <dbReference type="SMR" id="Q88WM8"/>
    <dbReference type="STRING" id="220668.lp_1599"/>
    <dbReference type="EnsemblBacteria" id="CCC78913">
        <property type="protein sequence ID" value="CCC78913"/>
        <property type="gene ID" value="lp_1599"/>
    </dbReference>
    <dbReference type="GeneID" id="57025183"/>
    <dbReference type="GeneID" id="66449483"/>
    <dbReference type="KEGG" id="lpl:lp_1599"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1348"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_9"/>
    <dbReference type="PhylomeDB" id="Q88WM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1375-MON"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268377" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="286" mass="29583" checksum="FA1B7C321A0D6571" modified="2011-11-16" version="2">MTKIIDGKAVAKKVNAQTATAVAELAAQGIQPGIAVIIVGDDAASQIYVRNKNRKATKLGMHSVVRQLPATTSQDELLAIIAAYNADDSIHGILVQSPLPAQINEPLITMAIDPKKDVDGFHPTNVGKLITNFPGNYPVANTPRGIMTMLADYGVDPAGKTAVVIGRSTIVGKPMAALLTNANATVTIAHSKTADLKAVARTADILVVATGIAHLITGADIKPGATVIDVGMDRDENGKLVGDVDFDSAQGIAGLITPVPGGVGPMTIATLMQTTVELAKWSDVSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WW9</accession>
    <accession>F9UNN1</accession>
    <name>MOAC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="1">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaC</name>
        <name type="ordered locus">lp_1492</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101438.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WW9"/>
    <dbReference type="SMR" id="Q88WW9"/>
    <dbReference type="STRING" id="220668.lp_1492"/>
    <dbReference type="EnsemblBacteria" id="CCC78820">
        <property type="protein sequence ID" value="CCC78820"/>
        <property type="gene ID" value="lp_1492"/>
    </dbReference>
    <dbReference type="GeneID" id="66449380"/>
    <dbReference type="KEGG" id="lpl:lp_1492"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1254"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_1_9"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="PhylomeDB" id="Q88WW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1281-MON"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000097806" description="Cyclic pyranopterin monophosphate synthase">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <sequence length="163" mass="17678" checksum="E54DC819237D4763" modified="2003-06-01" version="1">MTDQLTHFNDQNRAKMVDVTDKAVTHRVATATGQITMHPATLQRIHDGQIKKGDVLAVAQVAGIMAAKQTSSLIPMCHLIPLTGVDIHFTDNGQDTITVDALVKTKHVTGVEIEALLAVQVTLLTIYDMCKAIDRGMLINNIHLVEKDGGKSGHFVYPSTPKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X60</accession>
    <accession>F9UND8</accession>
    <name>CYSC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name type="ordered locus">lp_1379</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X60"/>
    <dbReference type="SMR" id="Q88X60"/>
    <dbReference type="STRING" id="220668.lp_1379"/>
    <dbReference type="EnsemblBacteria" id="CCC78727">
        <property type="protein sequence ID" value="CCC78727"/>
        <property type="gene ID" value="lp_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1379"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1158"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_9"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="PhylomeDB" id="Q88X60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1187-MON"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000105912" description="Adenylyl-sulfate kinase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <sequence length="207" mass="23130" checksum="F3E82E33AD96BF1D" modified="2003-06-01" version="1">MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYVLDGDNMRFGLNKNLGFSAEDREENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRANLEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTGIDAPYEAPIDPEITIDTSKQPLTASVQQVLNYLAEHHYVSLVTANEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XQ3</accession>
    <accession>F9UMU3</accession>
    <name>Y1140_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0316 protein lp_1140</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1140</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0316 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644127.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889046.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XQ3"/>
    <dbReference type="SMR" id="Q88XQ3"/>
    <dbReference type="STRING" id="220668.lp_1140"/>
    <dbReference type="EnsemblBacteria" id="CCC78532">
        <property type="protein sequence ID" value="CCC78532"/>
        <property type="gene ID" value="lp_1140"/>
    </dbReference>
    <dbReference type="GeneID" id="57024778"/>
    <dbReference type="KEGG" id="lpl:lp_1140"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.963"/>
    <dbReference type="eggNOG" id="COG4843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106166_1_0_9"/>
    <dbReference type="OMA" id="KLALGYI"/>
    <dbReference type="PhylomeDB" id="Q88XQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-974-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01515">
        <property type="entry name" value="UPF0316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000171943" description="UPF0316 protein lp_1140">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01515"/>
        </source>
    </evidence>
    <sequence length="182" mass="20644" checksum="F71AC006833DE30B" modified="2003-06-01" version="1">MHIDMGMLVLIFIINFAYITLNTVRFLLVMRGYRYFAAFASVIEITIYVLGLSLVLNRLNNPINLVVYALGYGVGVYVGMVIEDRLALGYTMISVILPDPKSSLPGVLRENGFGVTQHAAYGLEGERLELEILAPRKNERRLYGLIKDAAPNAFVIAYEPRYISGGFWLKRVKRRNARRKKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YI8</accession>
    <accession>F9ULZ6</accession>
    <name>UVRB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">lp_0772</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641029.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888749.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YI8"/>
    <dbReference type="SMR" id="Q88YI8"/>
    <dbReference type="STRING" id="220668.lp_0772"/>
    <dbReference type="EnsemblBacteria" id="CCC78235">
        <property type="protein sequence ID" value="CCC78235"/>
        <property type="gene ID" value="lp_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="57024476"/>
    <dbReference type="KEGG" id="lpl:lp_0772"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.652"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_9"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="PhylomeDB" id="Q88YI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-670-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138399" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="435"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="667" mass="76125" checksum="1018F9162240797C" modified="2003-06-01" version="1">MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAKVNKPTLILSHNKTLAGQLYGEFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAINDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQDHVVSLRVGMEIDRNDLLRKLVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIVADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVEMLKEMGYTSGIENYSRFMDGRKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDRARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSATPGPYEMDRTKHVVQQIIRPTGLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYLHSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLIQTIGRAARNEHGSVIMYADTTTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPELIASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQMKTAAKKLDFEQAATLRDTVMELKAQIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YL5</accession>
    <accession>F9ULW8</accession>
    <accession>F9ULW9</accession>
    <name>RF2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 2</fullName>
            <shortName evidence="1">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfB</name>
        <name type="ordered locus">lp_0741</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The gene for this protein contains a UGA in-frame termination codon after Leu-30; a naturally occurring frameshift enables complete translation of RF-2. This provides a mechanism for the protein to regulate its own production.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CCC78207" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CCC78207" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CCC78208" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78207.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78208.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888721.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888722.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YL5"/>
    <dbReference type="SMR" id="Q88YL5"/>
    <dbReference type="STRING" id="220668.lp_0741"/>
    <dbReference type="EnsemblBacteria" id="CCC78207">
        <property type="protein sequence ID" value="CCC78207"/>
        <property type="gene ID" value="lp_0740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78208">
        <property type="protein sequence ID" value="CCC78208"/>
        <property type="gene ID" value="lp_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0740"/>
    <dbReference type="KEGG" id="lpl:lp_0741"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.623"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_221244_2_2_9"/>
    <dbReference type="PhylomeDB" id="Q88YL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-643-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="chain" id="PRO_0000166824" description="Peptide chain release factor 2">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="377" mass="42652" checksum="FDD4DB1783085BDC" modified="2011-12-14" version="2">MKEGSFVELSEYKHLIEEMQSAVDDFRGSLDLDALNESIQENEARMAEPGFWDDQAAAQKVIDENNVLKGKYDTFKQLADEVGDLAVAYELLSEEPDAEMQAEFETDFQHAEHDLQQYRLNLLLDGPYDRNNAILEIHPGAGGTESQDWGAMLLRMYTRWAASHNFKVETVDYQAGDEAGIKSVTLLISGHNAYGYLRSEKGVHRLVRISPFDAAGRRHTSFASVDVMPELDDTVDVDIRPEDLKIDVYRASGAGGQHVNKTSSAVRITHVPTGIVVASQAQRSQLQNRQTALNMLRAKLYEREEEKKAKERAAIQGEQMDIGWGSQIRSYVFHPYTMVKDHRTNYESHHGQAVMDGDLDPFMDAYLQWKLAQRNPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YN8</accession>
    <accession>F9ULU6</accession>
    <name>PHNX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphonoacetaldehyde hydrolase</fullName>
            <shortName evidence="1">Phosphonatase</shortName>
            <ecNumber evidence="1">3.11.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphonoacetaldehyde phosphonohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnX</name>
        <name type="ordered locus">lp_0711</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in phosphonate degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18905"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="3.11.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. PhnX family.</text>
    </comment>
    <dbReference type="EC" id="3.11.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888699.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YN8"/>
    <dbReference type="SMR" id="Q88YN8"/>
    <dbReference type="STRING" id="220668.lp_0711"/>
    <dbReference type="EnsemblBacteria" id="CCC78185">
        <property type="protein sequence ID" value="CCC78185"/>
        <property type="gene ID" value="lp_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0711"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.598"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_12_0_9"/>
    <dbReference type="OMA" id="GRPAPWM"/>
    <dbReference type="PhylomeDB" id="Q88YN8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-620-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050194">
        <property type="term" value="F:phosphonoacetaldehyde hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01375">
        <property type="entry name" value="PhnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006323">
        <property type="entry name" value="Phosphonoacetald_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01422">
        <property type="entry name" value="phosphonatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000284589" description="Phosphonoacetaldehyde hydrolase">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01375"/>
        </source>
    </evidence>
    <sequence length="265" mass="28527" checksum="B578374832697798" modified="2003-06-01" version="1">MTIKAVIFDWAGTTIDYGSRAPIVAFQKAFANVGIQISEAEIRQDMGLDKYTHIHKIMDLPAIQNDWQARFQVLPTEDDCNQIFSNFKAILLSSLTEFGQLKPGMSAVIDYLTAHNISYGTTTGYDAEMLALVLPIAAKQGYRPAVNITSEQTGGVGRPAPAMLALAAEQLTVTDPTTVMKIGDSVNDILEGNNADAVSVGIIDGSNIMGLSELAFNALSPAEQAERRAHVTAAYQRAGADYILQSMAELPALLDQINQPVATDH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YN9</accession>
    <accession>F9ULU5</accession>
    <name>PHNW_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-aminoethylphosphonate--pyruvate transaminase</fullName>
            <ecNumber evidence="1">2.6.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-aminoethylphosphonate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">AEP transaminase</fullName>
            <shortName evidence="1">AEPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnW</name>
        <name type="ordered locus">lp_0710</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in phosphonate degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:17021"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57418"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="2.6.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.37" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YN9"/>
    <dbReference type="SMR" id="Q88YN9"/>
    <dbReference type="STRING" id="220668.lp_0710"/>
    <dbReference type="EnsemblBacteria" id="CCC78184">
        <property type="protein sequence ID" value="CCC78184"/>
        <property type="gene ID" value="lp_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0710"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.597"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_3_1_9"/>
    <dbReference type="PhylomeDB" id="Q88YN9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-619-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02326">
        <property type="entry name" value="transamin_PhnW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000286770" description="2-aminoethylphosphonate--pyruvate transaminase">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01376"/>
        </source>
    </evidence>
    <sequence length="366" mass="40479" checksum="4E21FC99EEE7A1B1" modified="2011-11-16" version="2">MKQPYLLLTPGPLSTTASVKDAMQIDYCTWDSDYRHVTETIRQQILAMAQANPENYTTVLLQGSGSFGVEATIGTAVPRTDATLMIAINGAYGHRISQIAEYYDIPHIDVVFNEDEAVDPVRIEATLADHPEITHFATVHSETTTGILNPIEALMPIMHEHGIVTIIDAMSSLGGVPISIDELDCDYLISSANKCVQGVPGFAFIIAKQATLAHTADNARSLCLDLYDQWQAMTKQPGKWRFTSPTHVVHAFAQALIELQAEGGVTPRYQRYRASQQLLSDGLQALGFELVIDPAIQGPIITSFKYPNVDFDFADFYQFIKQRGFVIYPGKVSNIPSFRIGTIGDVDTTDIQRLLTIIGDYQQLHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YW8</accession>
    <accession>F9UL86</accession>
    <name>RL10_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">lp_0621</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YW8"/>
    <dbReference type="SMR" id="Q88YW8"/>
    <dbReference type="STRING" id="220668.lp_0621"/>
    <dbReference type="EnsemblBacteria" id="CCC78101">
        <property type="protein sequence ID" value="CCC78101"/>
        <property type="gene ID" value="lp_0621"/>
    </dbReference>
    <dbReference type="GeneID" id="57024396"/>
    <dbReference type="GeneID" id="66448663"/>
    <dbReference type="KEGG" id="lpl:lp_0621"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.521"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_2_0_9"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="PhylomeDB" id="Q88YW8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-532-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154647" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="167" mass="17927" checksum="8C6487385CE417DF" modified="2003-06-01" version="1">MSKETIAVKAQEVEEVAEQLKSSVSAIVVDYRGLTVEQVTDLRKQLREAGVKMRVIKNKIMVRAADKAGFEDLKPVFAGPTAVAFSEEDPVAPAKILANFAKTADALQLKGGVIEGKVADLETVQEYATMPSREELLATIANLLQAPVRNVAYAVKAVAEKGDEDAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q890K1</accession>
    <accession>F9US40</accession>
    <name>SSB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="1">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ssb</name>
        <name type="ordered locus">lp_0010</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890K1"/>
    <dbReference type="SMR" id="Q890K1"/>
    <dbReference type="STRING" id="220668.lp_0010"/>
    <dbReference type="EnsemblBacteria" id="CCC77587">
        <property type="protein sequence ID" value="CCC77587"/>
        <property type="gene ID" value="lp_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0010"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.8"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_2_9"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="PhylomeDB" id="Q890K1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-8-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000096054" description="Single-stranded DNA-binding protein">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SSB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="1">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="200" mass="21684" checksum="64913A75CBB45B39" modified="2003-06-01" version="1">MINRTILVGRLTRDPELRYTNGGAAVATFTIAVNRQFTNQNGEREADFISCVIWRKAAENFANFTHKGSLVGIDGRIQTRNYENQQGVRVYVTEVVVENFSLLESRAESERHQAANGGSGNNNYNNGNSNYNNNNNGYSNQGQNAAPQQSSANNNNPFGNGNTGNASSAAPSSSANNNNQADPFANNGDQIDISDDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW8</accession>
    <name>F9UKW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101025.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888497.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0486"/>
    <dbReference type="EnsemblBacteria" id="CCC77983">
        <property type="protein sequence ID" value="CCC77983"/>
        <property type="gene ID" value="lp_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0486"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.400"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_1_9"/>
    <dbReference type="OMA" id="AREWQNV"/>
    <dbReference type="PhylomeDB" id="F9UKW8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-404-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="439" mass="48837" checksum="DB7ECD4462432F79" modified="2011-10-19" version="1">MKSDFNDFFLGMPVEHAEDTNLAIDGGNPVITKLGRRTTFPNITKEDVFQLMTSIQGEPEAVVNEFCEKYRKYVGANYAIATASGTCSLQLALIGAGVKPGDEVIIPAFTFIATAQAVVAAKAIPVFADIDPDTFDLDPAAVEAKITDKTAAIMPVHVHGLPAAMDELSDICQRHHLLLLEDASHAHSATYHGKMCGSIGDAAGQSLMADKNFPAGGEGGIAFFKTEESYQRALKFLDDSGLDFRMSWLAAAFGISQLDRLPYYDQIRQRNAHHLIAFLNNETRLFNGPYIPDGEKHSFNMFRIKLNVDLPEFKGIEDYKIKQVVQNAVLEEGVFAREWQNVPIPWHLPFKNKIGFGHSYPFSLDEGTPDYSNTKYPNVLDMLNTTLVLCRELRSPVEYEKLSHYEVAFKKLDNHIGEIAEMAKALNVKKPYERDARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ2</accession>
    <name>F9UKZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642054.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888521.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0515"/>
    <dbReference type="EnsemblBacteria" id="CCC78007">
        <property type="protein sequence ID" value="CCC78007"/>
        <property type="gene ID" value="lp_0515"/>
    </dbReference>
    <dbReference type="GeneID" id="66448563"/>
    <dbReference type="KEGG" id="lpl:lp_0515"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.424"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_2_2_9"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="PhylomeDB" id="F9UKZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-428-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="20832" checksum="4893A1B68DC26767" modified="2011-10-19" version="1">MIALIIVAVVLVLIAIYVVIYNGLVKSRMYTQEAWSQIDVQLKRRTDLIPNLVNTVKGYAKHEKSTLAEVISLRNQLTQVPSGDHQQAMAVSDQLTNSLKSIFALAESYPDLKANQEFGKLMEELTNTENKIAYSRQLFNSSAASYNMKLQQFPSNIIAGIHHFKNVEFLTVPEAEKAAPTVSFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB4</accession>
    <name>F9ULB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR</name>
        <name evidence="2" type="ordered locus">lp_3558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891035.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3558"/>
    <dbReference type="EnsemblBacteria" id="CCC80521">
        <property type="protein sequence ID" value="CCC80521"/>
        <property type="gene ID" value="lp_3558"/>
    </dbReference>
    <dbReference type="GeneID" id="57026757"/>
    <dbReference type="KEGG" id="lpl:lp_3558"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2968"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_9"/>
    <dbReference type="OMA" id="DYIFPRI"/>
    <dbReference type="PhylomeDB" id="F9ULB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3009-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01541">
        <property type="entry name" value="PBP1_AraR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
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        <property type="entry name" value="AraR_ligand_bind_dom"/>
    </dbReference>
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        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="358" mass="40930" checksum="2124ADFCC8A04A92" modified="2011-10-19" version="1">MENKYQKVKDALKEAILSGEYAIDAKLPTETEMMERFAVSRYTIRRAVGDLETEHFIYRIQGGGMFVQDWHKDWSSEHDSKIIGVIATHVADYIFPQIIYGIDQVISEGGYSLLLGNTHNNHQRERKNLINMLNSKVAGLIIEPTQSALDNPNMDLYQEIKDNGIPVLFINASYPNLDFQAVTTSDQEAEQRMIEYLFEMGHESILGIFQVDDAQGVHRMNGFVKAYQEQPEISYKSNILMYQSGDPFEKLAHRLDTYLQNNERPTAIACYNDQLAIRVMDYLKGKGLNIPTDISIVGFDDYHMSRYMSPGITTMNHEKTTMGEDTGRQMLRLLHKQPVESIVYTPKLIVRTSVADLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF7</accession>
    <name>F9ULF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102245.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3603"/>
    <dbReference type="EnsemblBacteria" id="CCC80564">
        <property type="protein sequence ID" value="CCC80564"/>
        <property type="gene ID" value="lp_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3603"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3007"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_4_9"/>
    <dbReference type="OMA" id="REINMHI"/>
    <dbReference type="PhylomeDB" id="F9ULF7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3051-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="26734" checksum="4FEC04AB9A8C1208" modified="2011-10-19" version="1">MTEAYIFEAERCDLAMVAREMFNRKNTNVAGGNISVKVTAPRDINYGSVHVKKDHQYLIMTPTFMSEAWFGKLSGAQILVVDLESGQQIDGVGRLTREINMHIGAYEANPGIKVVYHSHAEESMFWATIGQDMPNVTEITAVNQTLGKIKCLPYKEACSQELAEQVHASLLSLGDDALENIFLLNSHGVLITCTDLHEATRILETVEWNAKIAYQETIFKSLGLIKQYQSCGKDTDAFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF8</accession>
    <name>F9ULF8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myo-inositol (And similar sugars) transporter,major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iolT1</name>
        <name evidence="10" type="ordered locus">lp_3604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3604"/>
    <dbReference type="EnsemblBacteria" id="CCC80565">
        <property type="protein sequence ID" value="CCC80565"/>
        <property type="gene ID" value="lp_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3604"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3008"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_9"/>
    <dbReference type="PhylomeDB" id="F9ULF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3052-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="470" mass="50782" checksum="FD04906405E8C512" modified="2011-10-19" version="1">MDVSESTNKKSNSHTGFLWLATFIAAMGSLLFGYDTGIVNGSLEFMAVKGQLDLTAFQQGIVSSGLTLGAAFGAIIGGPFADKIGRKKILTILGIIFSVGALGCAFATNITILIVFRFILGLAVGSASANVPVYIAEIAPTELRGKMVTTAQVMIVSGQFVAFGVNAALTPLGAQNAAIWRWMLGLGTIPGIILWIGMYLIPESPRWLVSQGKMDKALGVLRRIRSAASVESEMKEIQDKDKADKELNAEQATFKELISKRWVVQILITGAMLGIIQQFAGINSIMYYGGKIIQESGFDTTVAAILNAGNGFLSIVGAVLGMFTIDWLGRRKLEFAGLTICGITLVSAGVIHTVAPNASWAGITIVVLVYLYIIFFQGTLGPVTWLINSEIFPQRYRGIGTGITIFVLWIGNFIVGLLSPVLLEWNMSNTFYIFAVCCVLGIIFVALRVPETKGVPLEEIEKYFRTKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH2</accession>
    <name>F9ULH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sorbitol operon activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">srlM1</name>
        <name evidence="1" type="ordered locus">lp_3621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102260.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891093.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3621"/>
    <dbReference type="EnsemblBacteria" id="CCC80579">
        <property type="protein sequence ID" value="CCC80579"/>
        <property type="gene ID" value="lp_3621"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3621"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3023"/>
    <dbReference type="eggNOG" id="COG4578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124480_0_0_9"/>
    <dbReference type="OMA" id="YIGQDIH"/>
    <dbReference type="PhylomeDB" id="F9ULH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3066-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009693">
        <property type="entry name" value="Glucitol_operon_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06923">
        <property type="entry name" value="GutM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011474">
        <property type="entry name" value="Glucitol_operon_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19752" checksum="81D7B2DB28DCE4AB" modified="2011-10-19" version="1">MGPLVYLGLMLVAAFLLQGLFGFIQIKNFSENYRIMRQQGRVLIGKNPKRFQSGTLLLLAIDQDGNIEEARIMKGVTVFVKFKPLPIMIGRNIADIATDYGTMMTVDRLTRGCILNAYRNFINFRTNQLAYEDLDTNTNIFAMPLLTQMKSGWYWITSKLQERTDMRRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI3</accession>
    <name>F9ULI3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,2-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891104.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3634"/>
    <dbReference type="CAZy" id="GH92">
        <property type="family name" value="Glycoside Hydrolase Family 92"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80590">
        <property type="protein sequence ID" value="CCC80590"/>
        <property type="gene ID" value="lp_3634"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3634"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3034"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_0_1_9"/>
    <dbReference type="OMA" id="MGHTFPG"/>
    <dbReference type="PhylomeDB" id="F9ULI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3077-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_92N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="1">
        <location>
            <begin position="235"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="715" mass="80860" checksum="C9E59763E51541EA" modified="2011-10-19" version="1">MKIDQIDIRQGTANSPQRSHGNCLPYSGVPFGMNYFAVQTNGANGAWFFQPDTPRFEGIRLTHQPSPWIGDYCHLLLMGVQWQDATKRPDFVGNYRPNEATFNAHHLAIYDDHFNVQTDLAPSTYGAIARYDFQQLELAHHGLMLQFSDHVTFEFTPTGVKLSVSDYHGGEDPNLTMYVELTISGFDRANSGYYDDQNHWFVTTEGHGHALTLLLASDQSLINCHLATSYVDRTQAQLNLKRLQDADLTALENVSAAQWNDYLSRVTIRDHHPELIQTFYTCMYRLFLFPQRFYELDVKNEPIHYDTKSKTIKSGLLYTNNGFWDTSKTVYALFSVLAPELLPKFLAGFLTSYNETGFLPRWLAPDERGMMPGNLVDSIIAESAKKGIALELMPRLLAAMRDSDSKPAKNSRYGRQGSADYDRLGYIPADKYPESVNWTQDYAYSDYCIGQVADVLDQTDIANKYWQLSKRYLNLLDPQTGFLRPKNSDGRFKEPFVPDSWGSDYTEGSAWQNSYSAFHDINGLMTAMGGPKRFDDQLTALCNTRPSYHVGGYQMVIHEMSEMAAVDYGQVAISNQPSFHLPYLFSYTGHREKTQVLVKQLRKLFNASTTGFPGDEDNGSMAGWFIFACLGFYPVCPADAEYVLGIPAFDHVTLHTADHDIQLTTTNNHDHNNFVQTMTLNGHHYDQATISHQQLLNATNIDVRLGLVPASVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI5</accession>
    <name>F9ULI5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructokinase</fullName>
            <ecNumber evidence="1">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sacK2</name>
        <name evidence="1" type="ordered locus">lp_3637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3637"/>
    <dbReference type="EnsemblBacteria" id="CCC80592">
        <property type="protein sequence ID" value="CCC80592"/>
        <property type="gene ID" value="lp_3637"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3637"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3036"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_3_0_9"/>
    <dbReference type="OMA" id="DIQAYYI"/>
    <dbReference type="PhylomeDB" id="F9ULI5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3079-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="30491" checksum="AB2309CA784D0467" modified="2011-10-19" version="1">MSRRLGSIEAGGTKFILAVGDETYQMGAKKRIPTLTPEETLAACIDFFKANPVDAIGLGSFGPIGIKHGTADYGHILATPKPGWAGTNIVGILTAALHVPIYFTTDVNASIYGEYIAGEAQAVDAAVYFTIGTGIGGGAIQDGNFIGGYSHLEMGHAPVMLHPDDDFVGSCPFHGNQCFEGVAAGPTIEARTGERGENLQRDNPVFDYIDYYAAQMAFNAYVNLTPEKIIFGGSVINDADMVKVRQYFDQLNNGYVQVPTDLIVHSHFADNASATVGDFALAASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI6</accession>
    <name>F9ULI6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
            <ecNumber evidence="5">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yesN</name>
        <name evidence="5" type="ordered locus">lp_3638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641582.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3638"/>
    <dbReference type="EnsemblBacteria" id="CCC80593">
        <property type="protein sequence ID" value="CCC80593"/>
        <property type="gene ID" value="lp_3638"/>
    </dbReference>
    <dbReference type="GeneID" id="57026819"/>
    <dbReference type="KEGG" id="lpl:lp_3638"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3037"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="OMA" id="ERFCLEW"/>
    <dbReference type="PhylomeDB" id="F9ULI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3080-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="383"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="486" mass="54789" checksum="867721CD568ACE1F" modified="2011-10-19" version="1">MRKVMLVDDEYMLLRGLKLLIDWESLGLEIVNTEQNPSLALKYLQDNDIDILISDMNMPEMPGPEFVAAAKKIQPAMELIVISGYSDFDYVRAGLQQNAVNYLRKPIDTDELLATLRGALDRLQAQQQQHQIASLAIQTQTRTLLTTDREPEQLQIIQALGIEFATPTTVRLIGVLNPLPPKDLVNYLRVIKAVKGFYTEREDFIIVFQGTTDQLNIFINEAPHQIGVAHRPFLIGAPIKNVGQLRTRYIQLRREIARQYFFETASGLRMMLPDTQESVSSTLPSYSEVKKALDGIDLTGFSIWLTHQFDAMKQANASDLLARQFALVVLLVLSDRLTKFDDKAAIIAAINHAKDVSDLKGQLQWVAELATEQGTQQFSRNVLAMRQIIKKRYPEQLSLAAVASELHLNAVYLGQLFKQEVGRSFAQFLNDYRVDVAVDLLRDSDLDIGQIAEAVGYQNSSYFYKLFKKQTGMSPGDYRKAGVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ8</accession>
    <name>F9ULJ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004891119.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3650"/>
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    <dbReference type="EnsemblBacteria" id="CCC80605">
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        <property type="gene ID" value="lp_3650"/>
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    <dbReference type="eggNOG" id="COG2508">
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    <dbReference type="HOGENOM" id="CLU_081318_0_0_9"/>
    <dbReference type="OMA" id="MHRNSLQ"/>
    <dbReference type="PhylomeDB" id="F9ULJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3092-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="32570" checksum="FF83313B9C7D765B" modified="2011-10-19" version="1">METQQLLSIYPQATISPRPSVAKNMVCVAIDAGKYICIDTTNLSNRELSLLELLTHTKSNATTGDAWSEFLTGRHTTAPQTTAKKLQILQFRVHFTERHADRSQWLSAIADTFEHVLHRAFITADSGYLLLTESLTDTSADLASLLALIDNDFYTNTHLFIGSTHRSSQDLPTTFALEQQLFSQNQQDTIVTLSSSLLPFLVNQHQPELQALRNSLSLDSDNKQLIRALYHTQGNVRQAASKLFLHRNTLLYRIEKFERCNGLNLKNMDDLVYCYLLTLGQVINQVEK</sequence>
</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891137.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3672"/>
    <dbReference type="EnsemblBacteria" id="CCC80623">
        <property type="protein sequence ID" value="CCC80623"/>
        <property type="gene ID" value="lp_3672"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3672"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="entry name" value="Cro/C1-type_HTH"/>
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            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCC80623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="15488" checksum="7CD034B6E4981BE9" modified="2011-10-19" version="1">MGIFSERLKEAMQQANITSAQLSKQTGIGRSSISQWLSNKYVAKHDKVTALAAVLNVSPDWLLGTTDVATAVSPEAVPIPVSVTPTPAVDPELITLWEQLDTKQRSKLIKKARKLLTKSAEQPNTKRKKNKKKKKGKKRK</sequence>
</entry>
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    <accession>F9ULP9</accession>
    <name>F9ULP9_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Prophage P1 protein 38, terminase large subunit TerL</fullName>
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        <name evidence="3" type="ordered locus">lp_0661</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0661"/>
    <dbReference type="DNASU" id="1062028"/>
    <dbReference type="EnsemblBacteria" id="CCC78138">
        <property type="protein sequence ID" value="CCC78138"/>
        <property type="gene ID" value="lp_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0661"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.553"/>
    <dbReference type="eggNOG" id="COG1783">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="PhylomeDB" id="F9ULP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-572-MON"/>
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        <property type="component" value="Chromosome"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
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    <dbReference type="InterPro" id="IPR035413">
        <property type="entry name" value="Terminase_L_C"/>
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        <property type="entry name" value="Terminase_L_N"/>
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        <property type="entry name" value="Terminase_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Terminase_3C" evidence="2">
        <location>
            <begin position="260"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="428" mass="50015" checksum="9427E32BC7C345E3" modified="2011-10-19" version="1">MKIKVNLAKTIGHGYTDFWRDHHFYRVIKGSRGSKKSVTTAHNLIYRLVKYHWSNILVVRRNANTNKTSTFVECKKAINDFHLERYFKYNESLPEITYLPTGQKIVFRGLDDPLKLTSVNVPTGELCWLWVEEAYEIESFSKLQTVIESLRGNDPQVFYQVTLTFNPWNEHHWLKREFFDQPRDDTFVRTTTVRCNEFVSDEYKQRLYSLYQTNPRRAKTVVDGEWGVAEGLVFEDNIEQIEFNAMDKIQECGQTGFGLDYGFSNDPNAFVAVAVDVRNKQLWVYNEMYTYHQTTPHIAEWLKVNGYERARIYADSANSERTAQLNDLGITNADSVVKTPVEAGIDQLWQYQIHVHPKCKNLWRELNSYVFDSDRMGNTLSKPKDQDNHAIDALRYAVRQYMGDYDGSLGVKWDEQYAIGRQMGVSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR9</accession>
    <name>F9ULR9_LACPL</name>
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        <submittedName>
            <fullName evidence="6">Prophage P1 protein 58, lysin</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0681</name>
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    <organism evidence="6 7">
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        <name type="synonym">Lactobacillus plantarum</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0681"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78158">
        <property type="protein sequence ID" value="CCC78158"/>
        <property type="gene ID" value="lp_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0681"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.573"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709497_0_0_9"/>
    <dbReference type="OMA" id="QATNDRN"/>
    <dbReference type="PhylomeDB" id="F9ULR9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-592-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388817" evidence="4">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="382" mass="41756" checksum="7A4FD6A7CD54B0F7" modified="2011-10-19" version="1">MKQPLKHKIILTGAAMMAAFFLGVNANAARMDMVDVSNNNGYMSTAEYVSMRNEFGVRALTVKISEGTTFKDGYAASNIANGQAAGLYVNSYHFAHYKTKAQAIAEADFAGQTAKAAGLPVGAVLATDVESAEEQEILSQATNDRNNAAFMKEIQKFGYRADIYTSGSWANNKMTIKSKTGWVAGYPYVMSGQKWYTNNNAWQWSGSAHFRISYGGFDVSQLYTDYYTAGQKSTVKPTDPDAVKANNNTFKPSTSAKWVKETKTYTLKAAVKLRTGASTSSSVVAILPAGTTVKTDQAIIQGGYRWVRQPRFNGYGYLATGPASNTLEYVNSGVTHMYYTVKPGDSWWSIAQRNGLSMTTLANQNGKTIYTTIYPGQRLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS9</accession>
    <name>F9ULS9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdF</name>
        <name evidence="6" type="ordered locus">lp_0692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888682.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0692"/>
    <dbReference type="EnsemblBacteria" id="CCC78168">
        <property type="protein sequence ID" value="CCC78168"/>
        <property type="gene ID" value="lp_0692"/>
    </dbReference>
    <dbReference type="GeneID" id="57024402"/>
    <dbReference type="GeneID" id="66448670"/>
    <dbReference type="KEGG" id="lpl:lp_0692"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.581"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052495_0_0_9"/>
    <dbReference type="OMA" id="IGYKYQR"/>
    <dbReference type="PhylomeDB" id="F9ULS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-602-MON"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="39101" checksum="D7B31B421421FF31" modified="2011-10-19" version="1">MATDLAYYQKLLSNGNYKAINWDRVSDAIDKSTWEKLTEQFWLDTRIPVSNDMADWRELDDDHRWVVGHVFGGLTLLDTLQSQDGLQALRRNVLTSHETAVLNNIQFMESVHAKSYSTIFETLNTPDEINEIFDWSDSEEFLQAKAQWIYKLYDNIDEDPLKQKVANVFLETFLFYSGFYTPLYYLGHNQLPNVAEIIKLILRDESVHGTYIGYKFQLGFKDRSEKQQAEFKDWMFDFLYKLYENEENYIHLVYDQIGWSDEVLTFSRYNANKALMNLGQDALFPDTAEDVNPVVMNGISTGTSNHDFFSQVGNGYRLGQVEAMQDTDYDIGNPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX8</accession>
    <name>F9ULX8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ordered locus">lp_0751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888731.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0751"/>
    <dbReference type="EnsemblBacteria" id="CCC78217">
        <property type="protein sequence ID" value="CCC78217"/>
        <property type="gene ID" value="lp_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="57024451"/>
    <dbReference type="GeneID" id="66448719"/>
    <dbReference type="KEGG" id="lpl:lp_0751"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.632"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_2_0_9"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="PhylomeDB" id="F9ULX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-652-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="224" mass="25514" checksum="0467F940B31D35A3" modified="2011-10-19" version="1">MRRLFDDELNDIDANFTEMGMMVSETIEKAVKAFIDHDRDLAQEIIDNDAKINQREVELEQKSFEMIALYQPVTSDLREIVTILKAVSELERMADYARNIAHATIRVKGNVRVPEIEAALSEMGNRVRKMVEEMLAAYVKSDDQEARRVAAKDAKVGEMYDRINEKGISKMERHPETVIGSTDYLNVATYLMRIGALVTNIGEWIVYLNTGEIIELNPESSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM38</accession>
    <name>F9UM38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein, YbbR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0819"/>
    <dbReference type="DNASU" id="1063934"/>
    <dbReference type="EnsemblBacteria" id="CCC78277">
        <property type="protein sequence ID" value="CCC78277"/>
        <property type="gene ID" value="lp_0819"/>
    </dbReference>
    <dbReference type="GeneID" id="57024518"/>
    <dbReference type="KEGG" id="lpl:lp_0819"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.694"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039811_2_0_9"/>
    <dbReference type="OMA" id="NNRWAVK"/>
    <dbReference type="PhylomeDB" id="F9UM38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-713-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394384" evidence="1">
        <location>
            <begin position="36"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="34640" checksum="9BB89692E6F16B52" modified="2011-10-19" version="1">MKKFMNSNWSMRLLALLCALVLFAYVNSLKTTHNASILTNSSSKTTLTSNRKVTISAPLELNVNSTKYFVTGYPENIKVTIEGPSALVTTTANTQNFKVYANLSKLAVGRHSVKVEVDGLNKELSYGLSQKYIHVNIQPRRTATYKVSADFNKANVADGYEVGSARLGTSSVKVTGAVSEVSKVAKVVAVVNTNKNLEKSVNQQAIIEALDANGQNLNVVLTPSTTSVYIPITQATTTKDVPIDLKASGKTAADTSYSFSSDTKSVTVTGTKAALAKLKSLPVNVDVTNVDSTTTKTVDVSTSDEDGISSVSPTSVKVKITVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM80</accession>
    <name>F9UM80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888833.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0871"/>
    <dbReference type="EnsemblBacteria" id="CCC78319">
        <property type="protein sequence ID" value="CCC78319"/>
        <property type="gene ID" value="lp_0871"/>
    </dbReference>
    <dbReference type="GeneID" id="57024559"/>
    <dbReference type="GeneID" id="66448822"/>
    <dbReference type="KEGG" id="lpl:lp_0871"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.739"/>
    <dbReference type="eggNOG" id="ENOG5032RH8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003962_0_0_9"/>
    <dbReference type="OMA" id="NIIYYFT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-755-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="272" mass="30075" checksum="1CC0BEE9746E11C6" modified="2011-10-19" version="1">MFSILDMINHALGYVNVNVKIKNQIYIGIGIAGNLYLGYVAIRLMQNGAWLRGILYMLVFLALIYFITLNVIYYFTNKTAKYDLSPRIEKLLGGKPKEALAAEKQAQQSQQQPYIPANGIFDGQELLPATVKTSRAEQENVHQIVDQLQAANIVRLDYGGLTDDAIIQQAQATGEPVYAIGQGIQIPFSQLKLENHRLVIYAGINQMDQSPVGHITKVGLTDVHDAHEDYKLYLASTVITGGMSKIAGRTSAIEQPGDYQVTAQVAYEGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA3</accession>
    <name>F9UMA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgm3</name>
        <name evidence="1" type="ordered locus">lp_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0900"/>
    <dbReference type="EnsemblBacteria" id="CCC78342">
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        <property type="gene ID" value="lp_0900"/>
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    <dbReference type="GeneID" id="57024583"/>
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    <dbReference type="OMA" id="SITIMNM"/>
    <dbReference type="PhylomeDB" id="F9UMA3"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="25847" checksum="14BA84962E192E77" modified="2011-10-19" version="1">MAQFSIYFVRHGQTFFNLYNRMQGWSDSPLTEYGQATATKVGQALANTAFDYYYSSDSKRAIDTAQLIRQAAGATAQPFKTLMNFREVFYGYFEGDDSSRTWSLVGRQYGVTSMHELLEHVPIDQTRDLMREIDPWHEAEDNSMYWERINQGFDYLKAHHDHHQKVLVVTHGTTIRSMVAHFAPEIDITNGPKNGSVTRIDINGDQIRVVDYAQDLADVKVNQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC6</accession>
    <name>F9UMC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0927"/>
    <dbReference type="EnsemblBacteria" id="CCC78365">
        <property type="protein sequence ID" value="CCC78365"/>
        <property type="gene ID" value="lp_0927"/>
    </dbReference>
    <dbReference type="GeneID" id="57024606"/>
    <dbReference type="GeneID" id="66448865"/>
    <dbReference type="KEGG" id="lpl:lp_0927"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.785"/>
    <dbReference type="eggNOG" id="ENOG5030H3Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127603_0_0_9"/>
    <dbReference type="OMA" id="WPNREFT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-801-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="181" mass="20392" checksum="1B6B9710ADCBFB51" modified="2011-10-19" version="1">MSRLAKFTVTLVGIVLVLLAVFELGQLYPIPWLTSWLADLTINYPMVWSILLMVFAIIAGIVGILLVIVGLFRPVKVSTLTYDGKVGQLTIPQRALERDLQYRLVNQLNLIDPEVHLKLRRRRRVRVKIDAMVNTDASLETTAQQAATLAQDYLKNQLGLTVEQPVVQVKPANHQRKLTVV</sequence>
</entry>
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    <accession>F9UMD2</accession>
    <name>F9UMD2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system, EIIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888885.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0934"/>
    <dbReference type="EnsemblBacteria" id="CCC78371">
        <property type="protein sequence ID" value="CCC78371"/>
        <property type="gene ID" value="lp_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="57024612"/>
    <dbReference type="KEGG" id="lpl:lp_0934"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.792"/>
    <dbReference type="eggNOG" id="COG1447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152490_1_1_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-807-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="110" mass="12396" checksum="894E1E92418AEC3E" modified="2011-10-19" version="1">MQKNTEHTLNVTMTMILKIGSARSLIAAALAEIAAYRYEAAREKLSQAETELLTAQRLQMRRLIENAKAQRFVHSTLFMNAQSALVNVMGELQMTENLIGAFERWEPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD7</accession>
    <name>F9UMD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction-modification system,specificity subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdS1</name>
        <name evidence="6" type="ordered locus">lp_0940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888890.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0940"/>
    <dbReference type="REBASE" id="7000">
        <property type="entry name" value="S.LplWORF939P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78376">
        <property type="protein sequence ID" value="CCC78376"/>
        <property type="gene ID" value="lp_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0940"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.798"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_0_2_9"/>
    <dbReference type="OMA" id="FADDWEE"/>
    <dbReference type="PhylomeDB" id="F9UMD7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-812-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="214"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="380" mass="42349" checksum="10B3CD43D79E502B" modified="2011-10-19" version="1">MKNENLVPKVRFKGFSDPWEQRKLGELGKIQGGGTPDSGIAEYWDGNVNWFTPTEVSNNGYLESSNRKITSLGLKKSSARLMPASTVLITSRAGVGRMGILKYPASTNQGFQSLILNSATDEYFIYSMQPIISKLANRLASGSTFTEISGKQMEKIEIMIPTTGEQNRISSLMKCINNLIAANEDKLEQLKTLKKLMMQKIFSQEWRFKGFTDPWEQRKLGDISKITAGGDIDKDKLSTRGRYPVIANALTNNGVVGYYDSYKVKGPAVTVTGRGDVGHAKTRIESFTPIVRLLVVSAPNFDINFLENAINNIRIFNESTGVPQLTAPQLGSYEFEYPCSSEQVCIGNVLHKIDNLIAANEDKLNQLKELKKYLMQNMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME8</accession>
    <name>F9UME8_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="5">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888901.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0952"/>
    <dbReference type="EnsemblBacteria" id="CCC78387">
        <property type="protein sequence ID" value="CCC78387"/>
        <property type="gene ID" value="lp_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="57024628"/>
    <dbReference type="KEGG" id="lpl:lp_0952"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.809"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_3_1_9"/>
    <dbReference type="OMA" id="NRHGHIY"/>
    <dbReference type="PhylomeDB" id="F9UME8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-823-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="629" mass="68742" checksum="BE4BF19E45CEA5BA" modified="2011-10-19" version="1">MDFERVVSMLKKMNQVKWDYQYDTVVIGFGGAGATAARFAADAHAKVLLTDAAPNGHEGGNTRYSAQLLGTVDSFDEGKKYYQNLTAPMQLDDSMVDTFVAGMANMRDYVQKYLNVDPVSVKNDFTAADSPISLDSAVHEFPEFDGVQSYDFTTVHHGIFDAALWKILRQKVLDRQQQIDVWLSAPAQHLIQDPTTNTIIGVQIERQHRLVNVRATNGVVLACGGFENNQQAIQDYLGAEHLAPLGTLFNKGAGIKMAQEVGADFWHMQNYESLGFLHGLSIAVPQGERGRLILGWPEVNHGSVITVADDGSRYFDESEANRHGHIYDHGMWRVPRTNVHPYLVFDETQYQQMLASQYTPINNLTDLVVKATTLNDLARVMEVDGTVLTKTVHDFNYFVESGTDYAFNRQVDTMRAFDGGPYYALKLTNNVLNTQGGPRRNDRAEILDANQQPIPHLYGAGELGGICANQYQGGGNLAECLIFGKIAGENAAKPKEETTQLVDEKAVAKPDANTSASVHQTGANDLLAEASPDITVGEHQYLGRSDDGIGGQVVVRITYVDQQLTHVEVVEQHETGEVGGQAVAELPAKMVAANTYDVDAVSGASVSSRAIKAAVKDALSQAEQTVSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH6</accession>
    <name>F9UMH6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0989"/>
    <dbReference type="EnsemblBacteria" id="CCC78415">
        <property type="protein sequence ID" value="CCC78415"/>
        <property type="gene ID" value="lp_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0989"/>
    <dbReference type="HOGENOM" id="CLU_192181_0_0_9"/>
    <dbReference type="OMA" id="QIMVLIV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-851-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="85" mass="9949" checksum="FC3759AE41E2912C" modified="2011-10-19" version="1">MYYHSTSGLFWIIIALLLYMLSKTDPKNFIIKQIRRFGWLINLAILTYIIARQIQQPTGVLQIMVLIVIGFSTMSSIYARFKHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH9</accession>
    <name>F9UMH9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0992"/>
    <dbReference type="EnsemblBacteria" id="CCC78418">
        <property type="protein sequence ID" value="CCC78418"/>
        <property type="gene ID" value="lp_0992"/>
    </dbReference>
    <dbReference type="GeneID" id="57024658"/>
    <dbReference type="KEGG" id="lpl:lp_0992"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.841"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119478_0_0_9"/>
    <dbReference type="OMA" id="QNIEVGI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-854-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="154" mass="18362" checksum="EA36E76C17928963" modified="2011-10-19" version="1">MDKQEDGVFFKKFKEQLGKHQFTIGISDLAKMTGVSQTQLRYWEQKNYIHSLKVSEKNTTHRYSYGMLMRVHFIKMMLDEGFTLAAAVERADGYNNQMEMMRIFMMTAFQGIEERDGHHMVKLGYFDEAKTQQLYCYIQDETPHYRLYPVKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS0</accession>
    <name>F9UMS0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase alpha chain</fullName>
            <shortName evidence="1">Citrase alpha chain</shortName>
            <ecNumber evidence="1">2.8.3.10</ecNumber>
            <ecNumber evidence="1">4.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate (pro-3S)-lyase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Citrate CoA-transferase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">citF</name>
        <name evidence="2" type="ordered locus">lp_1109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + citrate = (3S)-citryl-CoA + acetate</text>
            <dbReference type="Rhea" id="RHEA:19405"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57321"/>
            <dbReference type="EC" id="2.8.3.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>citrate = acetate + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:10760"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="4.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.8.3.10" evidence="1"/>
    <dbReference type="EC" id="4.1.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889023.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1109"/>
    <dbReference type="EnsemblBacteria" id="CCC78509">
        <property type="protein sequence ID" value="CCC78509"/>
        <property type="gene ID" value="lp_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1109"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.938"/>
    <dbReference type="eggNOG" id="COG3051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046521_2_0_9"/>
    <dbReference type="OMA" id="GHCDVAA"/>
    <dbReference type="PhylomeDB" id="F9UMS0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-952-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009346">
        <property type="term" value="C:ATP-independent citrate lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008814">
        <property type="term" value="F:citrate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006472">
        <property type="entry name" value="Citrate_lyase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40596">
        <property type="entry name" value="PTHR40596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04223">
        <property type="entry name" value="CitF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009451">
        <property type="entry name" value="Citrt_lyas_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01584">
        <property type="entry name" value="citF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="512" mass="54961" checksum="121934FD24C44443" modified="2011-10-19" version="1">MKNSVDRELPAELMTKLNYQGFESTEIGHPEIQRVAPKVHVSTGDNKVVDSVADVVKATVKDGMTISFHHHFRNGDFVFNQVMRAIIDAGIKDLTLAPSSLTGVMNDMVIEAIKAGTITNITSSGMRGSLGDFVSHGGLKNPVIFRSHGNRARAIEHGDIKIDVAFLGVPNADRLGNANGMAGKAVFGSLGYALMDAQYANQVVLLTDNIVAYPNTPASIKQTQVDYVVQVDQVGDPDKIGSGATRFTKDPKELKIAQTVNNVIVNSPYFKNGFSFQTGSGGAALAVTRYLRQAMLDNQIKASFALGGITKPTTDLLEEGLVDKVMDVQDFDKGAAASMHANPNQQEIDASWYADPDNKGAMVDQLDVAILSALEIDTHFNVNVMSGSDGVIRGAIGGHQDAATAKLTIISAPLVRGRLATIVPEVTTVVTPGDSIDVVVTEYGIAINPRRQDLVKALSHVPGVPVYMIEELQQLAEKKVGQPQPLEFTDRTVALIEYRDGTIIDTIKAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMU0</accession>
    <name>F9UMU0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, NAD(P)-dependent</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
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        <location>
            <begin position="6"/>
            <end position="120"/>
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    <evidence type="ECO:0000259" key="1">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="324" mass="35905" checksum="B1EEE5EA5F7FF56A" modified="2011-10-19" version="1">MSKTYRWAIVGLGNIAHSFVKYFDQPDGEIYAVCSRSQDKANAFAAEHNIPKAYGNLDELLADEQVDIVYVATPHNYHIDTILPALRAGKHVLSEKAITMSSTQLAIAKEVAASNHLILAEAMTLYHMPLYEKLHDFAAERHLGDLKMIQASFGSFKEPDPTNRFFNPDLAGGALLDIGVYALAFVEEFLTAKPYITGTTMHRFSSGVDESSTITLRNANDELATVALTFRAKMPKRGIVAYENGYFTVDTYPRADSATFTDSEGHTETITAGDSTNAMNYEIADMQKMVAGELHNTSLAKTTDVMDIMTAARAQWDFRYPFEN</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78606">
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        <property type="gene ID" value="lp_1222"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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        <location>
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    </evidence>
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        <source>
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    <sequence length="296" mass="32768" checksum="F7EBCD73DAECD12C" modified="2011-10-19" version="1">MQQHRNVLYLIIFGIYLASVTLQTTTFNEMIPHRVGVLIELATLAALLGLVVCLDTLTPGQIIGEVSLLVLVTVVTLTSGAHYLMPTIMLVIAAREVSFRQIIQVYLGVVGTILLLALVAAEVGLIKNITFATADGLRQSFGVVYTTDFAAHIFYLCAAYLYLLARRFRLVALLPVLFGLAMIYQFTKTMTDVIALLVLISLYLVYIYRRQLRWLRPMIRYSFLMLPLASGLIIGLSNIFNYQDRLLVALNNTLSTRLALGNNALLAYGVKLFGQAPIPINGWGGDRFETFTNGVG</sequence>
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    <accession>F9UN72</accession>
    <name>F9UN72_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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            <begin position="1"/>
            <end position="172"/>
        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="172" mass="19179" checksum="200BB34A5D88F766" modified="2011-10-19" version="1">MYFKKATLDDLDTIIDILSDGRNQLAEAGVNQWQGDYPSRKQITADIMQGSAYLFNADDNATVGAVAVVPSPDETYDTAKAEWLNTTAPYVVIHRVAIHSSHAGHGYATQLFEKIIAHIAADHPEIKSIRIDTHADNQAMQHLIAKMNFKRVGEMVGVYHVDDVCYVYEKML</sequence>
</entry>
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    <accession>F9UN77</accession>
    <name>F9UN77_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine S-methyltransferase (Cobalamin-dependent)</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="primary">metH</name>
        <name evidence="6" type="ordered locus">lp_1298</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.10" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101343.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889180.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1298"/>
    <dbReference type="EnsemblBacteria" id="CCC78666">
        <property type="protein sequence ID" value="CCC78666"/>
        <property type="gene ID" value="lp_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1298"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1098"/>
    <dbReference type="eggNOG" id="COG2040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_9"/>
    <dbReference type="OMA" id="HRPRMKA"/>
    <dbReference type="PhylomeDB" id="F9UN77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1124-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="32891" checksum="B0C85992D25C1333" modified="2011-10-19" version="1">MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQANVPAFEQAGIAAVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYLADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQQPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAVPLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARALSVSDSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN87</accession>
    <name>F9UN87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase, SAM-dependent</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889190.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1314"/>
    <dbReference type="EnsemblBacteria" id="CCC78676">
        <property type="protein sequence ID" value="CCC78676"/>
        <property type="gene ID" value="lp_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1314"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1108"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079190_1_0_9"/>
    <dbReference type="OMA" id="VLVVYHG"/>
    <dbReference type="PhylomeDB" id="F9UN87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1134-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="197" mass="21227" checksum="2C8DF5C038D75643" modified="2011-10-19" version="1">MNSTRGVTLIQLSSALAYSHALMNQVVNPGDHVIDATVGNGHDTVYLAKLVGTTGHVDGFDIQSAAIEATTTALDKAALTHQVTLWQTGHEHIADKIAADQPIKCAVFNLGYLPGGDKQIITKPTTTLTAIKAIQERLVTNGLIILLVYAGHPGGATEAQAVLDYVTNLDQHQFQVLQYQFINQVHVPPYLLAIQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN91</accession>
    <name>F9UN91_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rsuA</name>
        <name evidence="5" type="ordered locus">lp_1319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889194.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1319"/>
    <dbReference type="EnsemblBacteria" id="CCC78680">
        <property type="protein sequence ID" value="CCC78680"/>
        <property type="gene ID" value="lp_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="57024936"/>
    <dbReference type="KEGG" id="lpl:lp_1319"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1112"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_9"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="PhylomeDB" id="F9UN91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1138-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="27354" checksum="5FF196CC122A13E4" modified="2011-10-19" version="1">MRVDKFLHAMRIGTRTQVRRLIKDGHITANGEPVISGKQQINPGSDTVFLDDVQVRYQQYFYYVMNKPVGVITATTDSAAKTVMDLFNTTDFRDDLFPVGRLDKDTEGILVITNDGALSHDLLSPNHHVTKVYEAEVTGEITAAQLANFNDGITLKDGTELQPAQAEIVQFHEIENFTTIRIMIHEGKYHQVKRMVGTLGERVVGLRRIKFGSLTLPVGLLAGNYRALTDDELTALKADANQPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB7</accession>
    <name>F9UNB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101369.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1353"/>
    <dbReference type="EnsemblBacteria" id="CCC78706">
        <property type="protein sequence ID" value="CCC78706"/>
        <property type="gene ID" value="lp_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1353"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1138"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_9"/>
    <dbReference type="OMA" id="IMKVIFE"/>
    <dbReference type="PhylomeDB" id="F9UNB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1164-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="29659" checksum="26A5FF8F42E30A88" modified="2011-10-19" version="1">MYKMIVCDLDETLMNDDGTLSEKNAAAIQAAAAKGVYFVPNSGRSYTSFQNDLETMGLRDQPHQYSISYNGGLILENKDNRPLAVNAMPYEVAKGVFEAGIANQQAATHVYTQDTLYIYNPVSSDSDYLQNRGVTFTTMTTPDFEQFKTMNVMKIIMALPTMTDRKQMRADVEAIVDPSKLAVTYSSDRYVEFNPAGVDKGTAAVQLGKLLGITADEIIAAGDNSNDLPMLKAVGLPVSVANGIDAVKAAAKYVTVADNNHDALAEVINKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF0</accession>
    <name>F9UNF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1396"/>
    <dbReference type="EnsemblBacteria" id="CCC78739">
        <property type="protein sequence ID" value="CCC78739"/>
        <property type="gene ID" value="lp_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1396"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1170"/>
    <dbReference type="eggNOG" id="COG1221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014204_1_1_9"/>
    <dbReference type="OMA" id="TITMACA"/>
    <dbReference type="PhylomeDB" id="F9UNF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1200-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="403"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="749"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="851" mass="95063" checksum="8280D1BBE0E5140A" modified="2011-10-19" version="1">METTRELIYDTVRKLVLTDTRYHDGVTAMVIATQLKMQRTNVSAALNALVRKQKLVKTKTRPVQFLLAASHLQEPFTGLIGRLNSLQHAIKLAKAAALYLSGPLNIHIVANGGAGSTTFVHEIQNFVEQRGILTAASSPIIVKCRDYADDIHQLDSQLFGEHGQLAHSLWAHSEGGIVVIDHYDYLDGPQRAQLTSVMEAVASHKQPPLIILVSGIDQEILRTQQLIMKIELPDFKQRPWSERWALIRRFLTIEAQQSKRTIRLELAVAQALMLANYDQNLKTMKATITMACAQAYVRFMADADREVRVYLADLSPAVQQALAHERDYQQELAAVLAAADLSFAAKSSSGLSSDSLQASRQQVEPGTSPRSVQVPRSVEQSPSVIKPSIVQQRASNTQNLAQIVAPLIIKIVKDWQPDCERLLARPLTESVFNGLCLHINGMYRQMPTTKPASATMITQLQSQHVAEYEAAVKLAQVLATKLDLTISPAEVALLATFLVAQSPVTRHHPVVLYVMQGMGTAQALMRTTNTLSVVSNTYAYDVDLSADSTMVMKALKHKISEIDCGAGVLVIYDMGAIKWMLTTIQGELATKIRMIQVPVTLVGVDAARKSARVMDVDDVYHLVQVDLNQLNAEKTTKDELIITLCHTGEGGAAQLKDYIDQYSRLQMRVKALAIGHRDELVATVLRLQQVYQIHAFVGTFDPQLFGIPFISMAAIFEHSHQQLDQVLMFRPEAGRWDTYNQIYQYFKTQFEYAEVAKLQRVLPPLMDDLTTLYQLTEDQQIGLFVHLGSMIDRILAGKIVTTTAQTRKLVTQYSQDYQQLRRCLRPVEQTFKLIVNDEMIGTLLVILKQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF2</accession>
    <name>F9UNF2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PTS system, beta-glucosides-specific EIIA component</fullName>
            <ecNumber evidence="7">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pts15A</name>
        <name evidence="7" type="ordered locus">lp_1398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101389.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889255.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1398"/>
    <dbReference type="EnsemblBacteria" id="CCC78741">
        <property type="protein sequence ID" value="CCC78741"/>
        <property type="gene ID" value="lp_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1398"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1172"/>
    <dbReference type="eggNOG" id="COG1447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152490_0_1_9"/>
    <dbReference type="OMA" id="EVFETRA"/>
    <dbReference type="PhylomeDB" id="F9UNF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1202-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12425" checksum="BDF39A47A8904FD8" modified="2011-10-19" version="1">MTLANNTETQDIAMTLIAYSGEGRTLAFNALDAMHRDAFSESKMLLKKSSEALGKAHDVQTQLLVAEANGQQVSIDILLIHAQDHFMTSLLANELIAEMLKMSQKFERMVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL0</accession>
    <name>F9UNL0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sufS</name>
        <name evidence="8" type="ordered locus">lp_1470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101419.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889313.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1470"/>
    <dbReference type="EnsemblBacteria" id="CCC78799">
        <property type="protein sequence ID" value="CCC78799"/>
        <property type="gene ID" value="lp_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1470"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1232"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_9"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="PhylomeDB" id="F9UNL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1260-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="412" mass="44924" checksum="D0F5595A1840D608" modified="2011-10-19" version="1">MASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHTLAERATSQYEAARAKVQRFINAPKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISVMEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANKITDRTKIVSVTHASNVLGTVNPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGRENLLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQVQQHEQQLVNYLLPKLIAMPGVTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAVRAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSLQATKEFFEHGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM9</accession>
    <name>F9UNM9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101436.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1490"/>
    <dbReference type="EnsemblBacteria" id="CCC78818">
        <property type="protein sequence ID" value="CCC78818"/>
        <property type="gene ID" value="lp_1490"/>
    </dbReference>
    <dbReference type="GeneID" id="49284210"/>
    <dbReference type="KEGG" id="lpl:lp_1490"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1252"/>
    <dbReference type="eggNOG" id="ENOG5030AAA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2479393_0_0_9"/>
    <dbReference type="OMA" id="HYREFQD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1279-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="86" mass="10284" checksum="8AACED83350C6CD7" modified="2011-10-19" version="1">MLSKAEMNERDFQKLLQIALTDLGLRQTMLENEVSSVNEEMRSLEKDDKLDKLDMQIRAVRQDYEHYHQFVNSNFKLDVADQYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ9</accession>
    <name>F9UNQ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
            <ecNumber evidence="3">5.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">racD</name>
        <name evidence="3" type="ordered locus">lp_1523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.13" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889362.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1523"/>
    <dbReference type="EnsemblBacteria" id="CCC78848">
        <property type="protein sequence ID" value="CCC78848"/>
        <property type="gene ID" value="lp_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1523"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1282"/>
    <dbReference type="eggNOG" id="COG1794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055360_2_1_9"/>
    <dbReference type="OMA" id="CNTAHFF"/>
    <dbReference type="PhylomeDB" id="F9UNQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1309-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047689">
        <property type="term" value="F:aspartate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="27627" checksum="BA3CF635ADE49137" modified="2011-10-19" version="1">MKNCFGIIGGMGTMATEDFVHTVNRLTVTHRDQDYLNYVILNDAEIPDRTAYILDHNCANPLPSLEADVQLLNQLGVMFIVMTCNTAHYFIPALTALSNVPILNMPALAVTAACRSQQPRPLRIGILATTGTLESQLYQQLIRSNGHIPVIPNKQQQAQVMTLIYDDIKQRDFVDRVKFHGLIDQLLNAADCDAVILGCTELSVAQDAAPYDSERIIDAQYELARATVQRAQATKPALILRRRPSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU5</accession>
    <name>F9UNU5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644301.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1566"/>
    <dbReference type="EnsemblBacteria" id="CCC78884">
        <property type="protein sequence ID" value="CCC78884"/>
        <property type="gene ID" value="lp_1566"/>
    </dbReference>
    <dbReference type="GeneID" id="57025154"/>
    <dbReference type="KEGG" id="lpl:lp_1566"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1318"/>
    <dbReference type="eggNOG" id="COG4841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163967_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9UNU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1345-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008326">
        <property type="entry name" value="UCP034852"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034852">
        <property type="entry name" value="UCP034852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="11545" checksum="ACD0042A9717F4A5" modified="2011-10-19" version="1">MKITITDLASKWFHDDMGVTTGNGVRFYGKTYGKTAVHSGFSIGIMRDDEPHQPIAMVEKDGVNYYVNDRDEWFFKGYDLTVDYDEQNDGPKYDYTPNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV3</accession>
    <name>F9UNV3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptidase</fullName>
            <ecNumber evidence="5">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepE</name>
        <name evidence="5" type="ordered locus">lp_1574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101466.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889406.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1574"/>
    <dbReference type="EnsemblBacteria" id="CCC78892">
        <property type="protein sequence ID" value="CCC78892"/>
        <property type="gene ID" value="lp_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1574"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1326"/>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113223_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1353-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388895" evidence="4">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="23160" checksum="F81E53BE2929BDFF" modified="2011-10-19" version="1">MVKLLLSSRAFSTVAVTDAFFTLVAPVAKNSARIVIIVNSVSTGKNHPQMVALQQTVQQLGYAHVQLLDVLTDDLAALNTATVIILNGGYEFLLLKNLRETHVLERLRTLALAGKPIYGISAGAILLGPDLDLYVYLYPEDNTEQLASTTAINATTIRIYPHYDVHCEVKPQLPQLITDWEHKTGVTVKRLTNNQGLLVHGSQIQMIDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP29</accession>
    <name>F9UP29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent amidohydrolase, M20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1664"/>
    <dbReference type="EnsemblBacteria" id="CCC78968">
        <property type="protein sequence ID" value="CCC78968"/>
        <property type="gene ID" value="lp_1664"/>
    </dbReference>
    <dbReference type="GeneID" id="66449538"/>
    <dbReference type="KEGG" id="lpl:lp_1664"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1404"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_1_1_9"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="PhylomeDB" id="F9UP29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1431-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="377" mass="40590" checksum="709C9C05F75175BF" modified="2011-10-19" version="1">MMTTTLAAWMTTLRHQLHAHPELALQEVATTALIKQTLTELNIRLVDYPGETGVVAEIGHGAPIIALRADIDALPIQEDNELSFRSTIPGRMHACGHDFHTAALLGGARLLKVHEADLNGTVRLIFQPAEEGHRGAKMMIDNGVLAGVRAIAGFHNMPNLPVGTLAMKSGPLMASNDNFDVTILGQGAHAAMPEASHDPIVTLGELISNLQTIRSRNIAPDAALVLTIAAVQAGTTFNVIPNTANLRGTIRTFNTANRDLAKVRFYDIVRATAKMNQQTATIDWDRGPSCVNNNAALTAVLSRVLKDDFDIVPAQLCNADDDFALYQECIPGFYGFLGSGGNGTLHQSNYRCDDAGLTYGARFHELAATALLKWVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP41</accession>
    <name>F9UP41_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabZ2</name>
        <name evidence="5" type="ordered locus">lp_1677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640415.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1677"/>
    <dbReference type="EnsemblBacteria" id="CCC78980">
        <property type="protein sequence ID" value="CCC78980"/>
        <property type="gene ID" value="lp_1677"/>
    </dbReference>
    <dbReference type="GeneID" id="57025251"/>
    <dbReference type="KEGG" id="lpl:lp_1677"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1416"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_1_9"/>
    <dbReference type="OMA" id="NELICEA"/>
    <dbReference type="PhylomeDB" id="F9UP41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1443-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="15115" checksum="317140F95D1C9D13" modified="2011-10-19" version="1">MEVTDLIPQRFPLQLLDRIVAVQPGVSATAEKLVTINEWFFQSQTLTGRTMIRPVLLEILAQTGVVALLSMPEHHGNNVFFGGIRQADFKTDVRPGDRLEAMVTLTKLRRQIGTGHGVITCAGREVVSADLTFVMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG4</accession>
    <name>F9UPG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889617.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1821"/>
    <dbReference type="EnsemblBacteria" id="CCC79103">
        <property type="protein sequence ID" value="CCC79103"/>
        <property type="gene ID" value="lp_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1821"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1539"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHMARR"/>
    </dbReference>
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        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="145" mass="16717" checksum="62799397AE2D2D21" modified="2011-10-19" version="1">MTPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQVLRLSSNTLTPLLRRMEDAGWLQRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYHLTVDEYQQALALNQKIITALSQDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG5</accession>
    <name>F9UPG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione reductase</fullName>
            <ecNumber evidence="7">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gshR3</name>
        <name evidence="7" type="ordered locus">lp_1822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101564.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1822"/>
    <dbReference type="EnsemblBacteria" id="CCC79104">
        <property type="protein sequence ID" value="CCC79104"/>
        <property type="gene ID" value="lp_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1822"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1540"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_0_9"/>
    <dbReference type="OMA" id="SGHAAWH"/>
    <dbReference type="PhylomeDB" id="F9UPG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1567-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="5">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="449" mass="48418" checksum="8D116B087DDDFFAD" modified="2011-10-19" version="1">MADYDTIFIGSGHATWHAAVALAHAQHKVAIIEEDTIAGTCTNFGCDAKILLDGPFELTEQLKQYQGIGVNTTPTIDWSQLMAYKQQVIQPLSVQMTAVFKQLGITIITGHGELTDTHTVQVADSTYTADTIVIGTGQRPAKLAIPGADLMHDSRDFLDLPTMPKRLTLIGAGIISLEFANMAVLLGSEVHIIEFADRALPAFYSEHVKKMITHLQAAGVHFHFGEALSQVTKTATGLMATTASGLKIESDDIIAATGRIPNIEHLGLTKVGIKTDRHGIIVDDHLRTSIPNIYASGDVISKTLPKLTPTAIFESNYIAGQLLGSTAAIDYPVIPAVVFTLPRIAQVGVSVEAAQHDTEHFHVQALPYGKLLAFQYQNEVDADLQLVFDQENYLVGASIYGNGALDLINLLTMIIADHVSATTLSQKIFAFPSASVGIIDMLTPLLHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP0</accession>
    <name>F9UPP0_LACPL</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)(H)-dependent oxidoreductase, quinone oxidoreductase (QOR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101589.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889693.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1918"/>
    <dbReference type="EnsemblBacteria" id="CCC79179">
        <property type="protein sequence ID" value="CCC79179"/>
        <property type="gene ID" value="lp_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1918"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1616"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_9"/>
    <dbReference type="OMA" id="EVSGIEC"/>
    <dbReference type="PhylomeDB" id="F9UPP0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1641-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="34950" checksum="675394834E3203AC" modified="2011-10-19" version="1">MQVYVVNQPGGPEALQLTTLPKPNVKPGWTRVKVLGFGINHSEIFTREGKSPSVQFPRVLGIEVVGVVDETSVPATFTSGQRVVSIMGEMGRAYDGSYAEYVLLPNEQVYPIKTNLSIASLVATPETYYTAYGIFKSLQLKATDRVLIRAATSGVGIADLNLIKAYNPKIHVAGTTRRLVKRQQLIDAGFDEVIVAPDSARLPAATAHFDKIIDLIGPLSVKDSLSHLNEGGIVNMTGELGGLWTVPDFDPISDIPNGCYLTGFSSGDVSQTLLQDLFDFIAAYHVSVAPARIFNFNQVPAAHAYLQAADSFGKAIVLLDQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ9</accession>
    <name>F9UPQ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644459.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889712.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1938"/>
    <dbReference type="EnsemblBacteria" id="CCC79198">
        <property type="protein sequence ID" value="CCC79198"/>
        <property type="gene ID" value="lp_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1938"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1635"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="WKKNQTF"/>
    <dbReference type="PhylomeDB" id="F9UPQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1660-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="296" mass="32861" checksum="915AD93EA5E3D792" modified="2011-10-19" version="1">MELRVLRYFQAVVAELNISRAAERLHVSQPTISRQLKDLEDELGATLFERNGRHISLTSSGEYFATQANQIIALADKTLANINTAKEISGTIELGSAEMRSFLTIAQSIKKLQQQYPKIRINVTSSNANQIRTNLKTGNFDFGIVTEPTDKHDLNFIHLPGESRWGLLVPRHSPLADHDYISLADLEGQKIIVSAQHGTINQLQDWYGESTPKFTIVATYNLLYNASLLVSAGVGYALGIDGIINTNQSDLIFIPLTPRITARTSLVWTKGQRLSEAAKTFLTQLATDLQQQIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPU1</accession>
    <name>F9UPU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl/glycerophosphate transferase, teichoic acid biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagB3</name>
        <name evidence="6" type="ordered locus">lp_1977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101611.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889744.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1977"/>
    <dbReference type="EnsemblBacteria" id="CCC79230">
        <property type="protein sequence ID" value="CCC79230"/>
        <property type="gene ID" value="lp_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1977"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1670"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029598_0_1_9"/>
    <dbReference type="OMA" id="QVWHANG"/>
    <dbReference type="PhylomeDB" id="F9UPU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1694-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="386" mass="44157" checksum="4C58E85BB420D633" modified="2011-10-19" version="1">MASVKKVIYVWLVRVVSWLAHFSKNDQVIYLMSFADNLDFIQQLNQRVPGRLTVYYLPSAATGAAQLAQAGIATRPFHDSVRFALTGIPVITRAADVYLDNYYGFTAGLTRQSPQRLIQLWHAAGAVKTFGWGDPQTAQRPADDRRRFQTVYDQITDYVVGSEKMGTIFAASYHVPQTRMRVLGYPRSDRYCKSEWVMQTATAIYQKYPAFKQQEVILYAPTYRAGVQFALPADFKQLKLRPDQHLIIKLHPHLAEQERDLQARYPDLVTLVPEFSTDELLTVANTLVSDYSSVVFDYALLPNCQKIVFYVFDWNHYEQEVGLQADFRDWAPGPLVRTVVDLNHVLAMPGAPLQLTQFNQLWNTRNDGHAIERTLAYFYPRVTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPZ8</accession>
    <name>F9UPZ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein HS6-type (S12/L30/L7a)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640725.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889801.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2041"/>
    <dbReference type="EnsemblBacteria" id="CCC79287">
        <property type="protein sequence ID" value="CCC79287"/>
        <property type="gene ID" value="lp_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2041"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1726"/>
    <dbReference type="eggNOG" id="COG1358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157804_5_0_9"/>
    <dbReference type="OMA" id="MSEVEYI"/>
    <dbReference type="PhylomeDB" id="F9UPZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1748-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="101" mass="10787" checksum="D36759BAA6509956" modified="2011-10-19" version="1">MTPKQACLNLLGLSRRASKQIAGEGLALAAIRNQTAKLVFIASDAGPTTAKKFHDKAQSYDVPVIDTFTKAELNTATGNKRTVYAITDAGFAKKMVAIMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ97</accession>
    <name>F9UQ97_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">lp_2158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889900.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2158"/>
    <dbReference type="EnsemblBacteria" id="CCC79386">
        <property type="protein sequence ID" value="CCC79386"/>
        <property type="gene ID" value="lp_2158"/>
    </dbReference>
    <dbReference type="GeneID" id="57025692"/>
    <dbReference type="GeneID" id="66449921"/>
    <dbReference type="KEGG" id="lpl:lp_2158"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1827"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_9"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="PhylomeDB" id="F9UQ97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1847-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="367"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="558" mass="61807" checksum="FC3958C30579CCF2" modified="2011-10-19" version="1">MKRLNVKNNETAVFAVGGLGEIGKNTYGIQFQDEIILIDAGIKFPEDELLGIDYVIPDYSYLVANQQKIKALVITHGHEDHIGGIPFLLKQINVPIYAGPLALALIKGKLEEHGLLKTTELHEINEDTVLKFRKTRVSFFRTTHSIPDTLGIAVQTPPGTIVETGDYKFDLTPITNQPPNLQKMAHLGERGVLALMSDSTNAERPIWTKSERWVAQSIRHIFEQVEGRIIFATFASNISRIQEAAQVALEHHRKIAVFGRSMEAAIVNGRELGYLNIPDEAIVDANDLRSLPANKVMILCTGSQGEPMAALSRIANGTHRQISIEPGDTVIFSSSPIPGNTLSVNHVINELEEAGANVIHGKVNNIHTSGHGGQEEQKLMLRLMKPKFFMPIHGEYRMLKIHTELAEQCGVPLDHSFILENGDVLAFTKDSARVAGHFGAGDVYVDGSGIGDIGNVVLRDRQVLSEEGLVVVVATINLNKKEIQAGPDILSRGFVYMRESGDLINEARRHVFRTIRRKMKSDKATEATIRNAIIDDLQSFLFDKTERHPMILPMLIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQN9</accession>
    <name>F9UQN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, DUF1648 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2334"/>
    <dbReference type="EnsemblBacteria" id="CCC79528">
        <property type="protein sequence ID" value="CCC79528"/>
        <property type="gene ID" value="lp_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2334"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1973"/>
    <dbReference type="eggNOG" id="COG5658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1371566_0_0_9"/>
    <dbReference type="OMA" id="IWRIAVS"/>
    <dbReference type="PhylomeDB" id="F9UQN9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2012-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="208" mass="23195" checksum="E77E4504819070D9" modified="2011-10-19" version="1">MTKRNLQLWLSYIVILLPMSYGVVNYAALPAKMAIHFNLDNQPNGMAAKLLVVVGFPIMMMAFQLICVGVTRLNANHKAPAPRFEQMIIWIVPVLSSVIYATTISYSLGHQLDIWRIAVSLIAFIFMAIGNYLPTISANQYAQMHRGGHTIRPMIWRRVRYWLGYTLVGGGILLLLSIVTTAWVSVSLMGIIVAALVIMSLYGTLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ2</accession>
    <name>F9UQQ2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2350"/>
    <dbReference type="EnsemblBacteria" id="CCC79541">
        <property type="protein sequence ID" value="CCC79541"/>
        <property type="gene ID" value="lp_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2350"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1986"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_9"/>
    <dbReference type="OMA" id="NYFQHRP"/>
    <dbReference type="PhylomeDB" id="F9UQQ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2025-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394401" description="Lipoprotein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="29890" checksum="E8E3D9899B63F985" modified="2011-10-19" version="1">MKKKGILGLLAVAATAILLVGCGKSSSTKTTTITVGASSVPHAQILKHVQPELKKEGVNLKIKVFQDYVLPNKALASKELDANYFQHIPFLDNWNKENNGSLVSAGKVHLEPIGVYSKKVKSLKDLKDGATVLVSSNVADYGRVLTLFKDAGLITLKKGTDLTSATFNDIKTNKRHLKFKHSYEAKLMPTFYKNNEGDAVVINANYAVQAGLNPKKDAIALEKSDSPYANIVAVRKGDKNKPAIKKLMKALRSKSTQKWIEKKYKGAILPVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS9</accession>
    <name>F9UQS9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pmi</name>
        <name evidence="8" type="ordered locus">lp_2384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 7">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101726.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2384"/>
    <dbReference type="EnsemblBacteria" id="CCC79568">
        <property type="protein sequence ID" value="CCC79568"/>
        <property type="gene ID" value="lp_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2384"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2014"/>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020529_0_0_9"/>
    <dbReference type="OMA" id="DTFFINT"/>
    <dbReference type="PhylomeDB" id="F9UQS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2053-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="321" mass="35949" checksum="D1E884BC2C2BD823" modified="2011-10-19" version="1">MSEPYFLKPVFHEKIWGGTKLHDDFNYDIPSDHTGECWAISAHPHGPATVENGPYAGMTLDRVWAEHRDVFGDAKGDVFPLLTKILDASEDLSVQVHPDDAYAAEHEHELGKTECWYVIAAEPGATMIYGHHAKTREQLAKWINNGEWNKLLRRVPVKPGDFLYVPSGTIHAVGKGIMVLETQQSSDTTYRLYDWDRVDKTTGQKRELHLQQSIDTTNVPHHDPDLDITTTQVGDATVTKYVQSPFFGVWQWRLTNGQATFNRGTAPYTLVSVLDGEGSIVVDGQDYPLSKGVHFILPFDVKQWTLKGDLQIIASEPGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT0</accession>
    <name>F9UQT0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644662.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2385"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="CCC79569">
        <property type="protein sequence ID" value="CCC79569"/>
        <property type="gene ID" value="lp_2385"/>
    </dbReference>
    <dbReference type="GeneID" id="57025913"/>
    <dbReference type="KEGG" id="lpl:lp_2385"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2015"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_0_9"/>
    <dbReference type="OMA" id="AGWAVRY"/>
    <dbReference type="PhylomeDB" id="F9UQT0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2054-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="37535" checksum="8968401CB80D3475" modified="2011-10-19" version="1">MLTFSRTAALINQMVQDQVIPGASYALIDGAEWHTNQVGVAQIKPTIKPLWPDAMYDLASVTKVVGTTTVAMQLMQNGQLEIDRPVHDYLPTLQSTTITVRNLMTHTSGLSGYIPNRNALSADALLAAIQQLPISERNRNHRVVYTDLGLIIMGQVIERILGAAIQPIITERVLQPLGLAHTSFQPQLAQTVPTTYSMKTGLLRGIVHDPKARVLGEHCGSAGLFASVTDLVRFSQLMLGQIDVPAVLSQATIASLYQDWTPNQHLRRSFGWNLWHRSDETLPVIFHTGYTGTLLMLDRQRQRGLVFLSNRVHPVANNSVFLPARRRLIAAWLADTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQV6</accession>
    <name>F9UQV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890109.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2416"/>
    <dbReference type="EnsemblBacteria" id="CCC79595">
        <property type="protein sequence ID" value="CCC79595"/>
        <property type="gene ID" value="lp_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2416"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2042"/>
    <dbReference type="eggNOG" id="ENOG5030AII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165430_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2080-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021146">
        <property type="entry name" value="Phafe_gp6_head-tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05135">
        <property type="entry name" value="Phage_connect_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13485" checksum="24743D9E87E5E612" modified="2011-10-19" version="1">MSGVQDSGKTLENVITLLGITPTDNERKRLTLYIDHAEQAIVLYLGRSVRISGLPEGLDYIVENLAVTKFNKFHNEGEKSHSEEGLSFQFNVNDLAPYYPDLQAWVDGQAKTTRSATAIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR78</accession>
    <name>F9UR78_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisK</name>
        <name evidence="9" type="ordered locus">lp_2563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UR78"/>
    <dbReference type="STRING" id="220668.lp_2563"/>
    <dbReference type="DNASU" id="1062771"/>
    <dbReference type="EnsemblBacteria" id="CCC79717">
        <property type="protein sequence ID" value="CCC79717"/>
        <property type="gene ID" value="lp_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2563"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2153"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_2_1_9"/>
    <dbReference type="OMA" id="KRIGHIT"/>
    <dbReference type="PhylomeDB" id="F9UR78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2209-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
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        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="31659" checksum="C145F7AEB64FCF21" modified="2011-10-19" version="1">MLMDGHTHTELCPHGSGEATEKMIQRAIQLGFQRYCITEHAPLPPAFRDQYEGTPAGYTEASLRENQVADYLALANGLKTKYAGQIEISVGFEVDFLPEHVAWTRDFLNTYGPRTQESILSVHFMRGLRQHFWCVDMSTDDFAAGFGQWLKTPQRVFEQYYQTVLASVQADLGPYAPQRIGHMSLVRKYQDYFGLTEPLDVHNLQLVDQTLALVKQQRRQLDLNLAGLYKPYCNDFYPGEQILQRAQKLDIPLVYGSDAHDIASVGRGYHLIKKLIEG</sequence>
</entry>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2614"/>
    <dbReference type="EnsemblBacteria" id="CCC79757">
        <property type="protein sequence ID" value="CCC79757"/>
        <property type="gene ID" value="lp_2614"/>
    </dbReference>
    <dbReference type="GeneID" id="57026018"/>
    <dbReference type="KEGG" id="lpl:lp_2614"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2196"/>
    <dbReference type="eggNOG" id="COG1131">
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    <dbReference type="PhylomeDB" id="F9URB8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2248-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="236" mass="26375" checksum="FA8DE4B6569F38F6" modified="2011-10-19" version="1">MTALTIKDLRYKHNQRMILQNVQLTLAPSKIVGLLGENGAGKTTLMRLITGSAKGQGSIVINGATTAVARKQQVSFTDHLTGFSAGMKLQQIAQFYQLVYPDFDAKRYQELVDFLELNQQQKLGELSKGTREKLIIALTLSRKVALYLLDEPFSGIDSMSRKKIINSIIKWTPAEATLLISDHYVTEIAPILDEIVVVKDQTIVVHQGADEIRDEHGMELEDYYESLYMGGVTDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC6</accession>
    <name>F9URC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101856.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890279.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79765">
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        <property type="gene ID" value="lp_2624"/>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.2204"/>
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    <dbReference type="HOGENOM" id="CLU_163968_0_0_9"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045507">
        <property type="entry name" value="DUF6483"/>
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    <dbReference type="Pfam" id="PF20092">
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCC79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="118" mass="13232" checksum="569B1304D698EDBE" modified="2011-10-19" version="1">MQDESDWLMRQLHAFATGLGYTLSRHKGGTTEVVFPQNQNQPLPHQVELAQLIDRKAYAQAAQRLLALQFAMTEAEFLQLGIWLYATLNQFDDQSLAAGGISRTSLVAGLEQLQQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG6</accession>
    <name>F9URG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_2680</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642623.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890319.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79805">
        <property type="protein sequence ID" value="CCC79805"/>
        <property type="gene ID" value="lp_2680"/>
    </dbReference>
    <dbReference type="GeneID" id="57026066"/>
    <dbReference type="KEGG" id="lpl:lp_2680"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2244"/>
    <dbReference type="eggNOG" id="ENOG503024T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2105890_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2296-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13264" checksum="EC47D2CB86B67D45" modified="2011-10-19" version="1">MANNNFGLALGFLVILLLWIYQRVRMPKMRSLAGYMSRRAIENEETWRFAQRFYSMFGIEIFSILLIGAIIGGLFKIPLLQSFNFQAIALAVGLIMQNVATERELKHQFPKSPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ7</accession>
    <name>F9URJ7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ordered locus">lp_2721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890350.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2721"/>
    <dbReference type="EnsemblBacteria" id="CCC79836">
        <property type="protein sequence ID" value="CCC79836"/>
        <property type="gene ID" value="lp_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2721"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2276"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_3_9"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="PhylomeDB" id="F9URJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2327-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="192" mass="20647" checksum="E731AD2DB952BE63" modified="2011-10-19" version="1">MPNKIAVFASGNGTNFVALHQAIIERQLPVVIGLLVCDQPTAPVIDKARAANVPILIVDFHDYANKAAAEAIILTALQARQIELVLLAGYMRIIGPTLLNAYVHKIINIHPALLPKFPGRHGIEDAFAAGVTETGVTIHYIDAGIDTGQIIAQRVVPVAPDDTLASLATRIHDCEHQFYPDVLQTLINEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM7</accession>
    <name>F9URM7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890380.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79866">
        <property type="protein sequence ID" value="CCC79866"/>
        <property type="gene ID" value="lp_2755"/>
    </dbReference>
    <dbReference type="GeneID" id="57026127"/>
    <dbReference type="GeneID" id="66450404"/>
    <dbReference type="KEGG" id="lpl:lp_2755"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2306"/>
    <dbReference type="eggNOG" id="ENOG5033MI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177694_0_0_9"/>
    <dbReference type="OMA" id="YHTWGWG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2357-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="105" mass="11957" checksum="26BBC411A5449442" modified="2011-10-19" version="1">MIASLIYWVVVVGLIVWGVWMAILSAYWASQKQNGNIFFIAIMNTLGALAGLLVWWVFNNQDWQYYWLSSTVKTTNLLGIVLICYVVLIVIEFIQGRGIKPETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN0</accession>
    <name>F9URN0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    <sequence length="167" mass="19323" checksum="2BF7229AAC4ADB07" modified="2011-10-19" version="1">MANSEDQMDKHLQSAIFGAPVLHPDEQHRNLGTFHERIDVGITFTQALMRDYSTELKSEMAAHPDYQLLLHGLLDEDILNRYVKLANQQHIRFAIRNDLMYQHTPTSLAIALVANCAITPPTIDIDERFPVPPLNTTTDWSHDVLIDHIHRHLERNRQLFSIKHHLI</sequence>
</entry>
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        <submittedName>
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    <organism evidence="9 10">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="395" mass="42927" checksum="9DF7CCF4BE11F2F0" modified="2011-10-19" version="1">MNSKSLNKSTVLLMAISAAIVVANINYIQPIEADIAQQFNLPNAVIGAVAMLTQLGYAFGLLLIVPMGDIMNRRMLIMRLLVLAIISALLAFVAPNIWVYALASLLIGITSVAPQVIIPYAGFLAPRNQRGQVLGNVLSGLLVGVLLSRTVSGVLASYLPWQMVYLIAAILIAGLWLVLWRKLPHDPVTTHTTNYKAMIQTVPQLVKRYPVLRASAVNGFVLFGVSNIFWATLVFYLQHQYGWGSREAGLLALLGVTGVLAAPLIGRLADRFRPRTIIGLGLVLSTLAYVVFWLSGTHLVGLIIGIVILDLGTQFGQVANQTRIQSIDVHASSRFNSVFMFGYFMGGALGSFCGNVLWDLAGWNGVCGLAVVVLMIGFYAHFVHYPRVVTRQAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY9</accession>
    <name>F9URY9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS), N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2896"/>
    <dbReference type="EnsemblBacteria" id="CCC79978">
        <property type="protein sequence ID" value="CCC79978"/>
        <property type="gene ID" value="lp_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2896"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_10_9_9"/>
    <dbReference type="PhylomeDB" id="F9URY9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="110" mass="11963" checksum="D60449F6AF16CCAB" modified="2011-10-19" version="1">MSQPSTVTLKTKLAILSVGLLSFVGILVETSMNVTFPTLIKTMGVSLDTVQWLTTGYLLLTTIVMSTTAYVLKRFNPKPLFLFAALVCLLGGILCWLAPNFPVLLTGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ3</accession>
    <name>F9URZ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890496.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2901"/>
    <dbReference type="EnsemblBacteria" id="CCC79982">
        <property type="protein sequence ID" value="CCC79982"/>
        <property type="gene ID" value="lp_2901"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2901"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2424"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004534_1_0_9"/>
    <dbReference type="OMA" id="MQIGIGK"/>
    <dbReference type="PhylomeDB" id="F9URZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2478-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1106" mass="115315" checksum="A8E74E64AE6DC69B" modified="2011-10-19" version="1">MKMIRDEWRSIRHSKILWISVSVMILIPFLYSIFFLKSVWDPYGDTQNLPVAVVNEDKSVNYQGEKFAVGKQVVTNLKKNNDLDWHFVSAKKAKQGLKDRKYYTVVTIPSNFSKNATTMTDTNPKKMNLHYETNESLNYIAKVITDTGVSRVNKSIRAQVTKAYALAIFKQIRTAGKGYQKAVDGATKLKDGGVELQDGLTTYTTGVHTLKNGTTELNTKVQQLPAGIAKLADGGSALKTGLDTLNSKTGALASGVSQLSDGSGQVTSGLGTLDSKTGALVSGVSQLATGSAKVSNGLTTLNGKTGTLSTGVVKLADGSKALQVGIVKYTGGVYTVSQGLSKLNSQTGELSKAVPLLKDGSSTLKTGVSDYTSAVNKIDGKLKTASNGAGMLSQGANQLKESTSGLEAQSTQLLSGATDVNNALKGIHSGSSTVTTGLSDLYSVATSDSEKKQIATLQSGMTAMASTLEDVDALIANLKGNANAANISALNSAINNDVATLTASTDTSNVSAEINTKIESIKDAQHLTDAQVKALEDTLSSVGKGNSDSTAKQQAATDLNAKMKQVQTTLGTVSKATTVDASLAQSFEKLQSGVNTYIDSVNQLAAQIQKLQAGSAKLTDSLEQVQSGTSQLTTGLTQLDEAVPGLTSGISNLSSKTTDLSSGLGQISEGTTALNSKSADLNSGAGKIQGGLTALNGQVPTLVGAIAQLNNGTTELNKSSSTLNSGANQVAAGNQALNVQVPTLVSAISMLTGGSGQVTNGLIQLNGQVPVLASGVQQLFAGSSKVTNGLVTLNGQVPVLVSGVQQLDTGAGQLNSGLQTLQGSTGQLTSGVSQLNDGATQLDNNSAKLLSGTKQIKNGNKTLATSLQEGADQVNATPLKNANAKMMAAPTKTSYKDYTHVPNYGHALAPYVLSLALYVGAIVFNFAYPIRRIADDDGTPTQWFWSKVAVGGPVALAMAVIEATVLLVAGLKPISVPEYYLTAIMIALASMFLVMFLSMLFDNPGRFVAMVILMLQLGGSGGTFPMEITNKFFNAIHPYLPLTYSIQAFRQALTGGWGSGIFWSSIVVLAGITIVSLGLLWASMVFLKQHDMQVPAEAEIQMKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ7</accession>
    <name>F9URZ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2907"/>
    <dbReference type="DNASU" id="1063309"/>
    <dbReference type="EnsemblBacteria" id="CCC79986">
        <property type="protein sequence ID" value="CCC79986"/>
        <property type="gene ID" value="lp_2907"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2907"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2428"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_9"/>
    <dbReference type="OMA" id="PYFPFSM"/>
    <dbReference type="PhylomeDB" id="F9URZ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2482-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="181" mass="21451" checksum="1FF00425ABD66AB6" modified="2011-10-19" version="1">MTATITIRPLQRAELTMLWQLGFSDPNAEWTRWNGPYFHDQLPTQTDFETIIGPRDWLIRPRNWVITRDGVIVGSVNWHFVDGSLKRWLEVGIIIYNQEHWGEHIGRTALTKWLTHLFQEETTLPHIGLTTWSGNMRMMQLAEAVGLKQEAWIPQVRYWQGQYYDSVKYGILRNDWQVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ordered locus">lp_0048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0048"/>
    <dbReference type="EnsemblBacteria" id="CCC77617">
        <property type="protein sequence ID" value="CCC77617"/>
        <property type="gene ID" value="lp_0048"/>
    </dbReference>
    <dbReference type="GeneID" id="57026903"/>
    <dbReference type="KEGG" id="lpl:lp_0048"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.39"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075800_0_0_9"/>
    <dbReference type="OMA" id="GFCYPGK"/>
    <dbReference type="PhylomeDB" id="F9US70"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-39-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="46"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="210" mass="24100" checksum="04E519A3AAD56301" modified="2011-10-19" version="1">MGKVSSLKLKTNRRCIYITTIKEITEAIKADPDNAEYTAKGWDPLFHVLPTATILVISQAPGRIAQNTKTYFNDASGDRLRDWMGVTREQFYQSDRIAVMPLDFYYPGKGKSGDLPPRKGFMDKWHEPLLAMMPNVQLTLLVGQYAIKAYLGRSRQKTLTATVQNYQDYLPDYFPLVHPSPLNYGWQKKNPWFQATVVPDLQRRVQIALK</sequence>
</entry>
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    <accession>F9US96</accession>
    <name>F9US96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2005-11" db="PDB data bank">
            <title>Crystal Structure of ACMDS from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Das K."/>
                <person name="Xiao R."/>
                <person name="Acton T."/>
                <person name="Ma L."/>
                <person name="Arnold E."/>
                <person name="Montelione G.T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH MANGANESE</scope>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101982.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890540.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2F6K">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-307"/>
    </dbReference>
    <dbReference type="PDBsum" id="2F6K"/>
    <dbReference type="SMR" id="F9US96"/>
    <dbReference type="STRING" id="220668.lp_2961"/>
    <dbReference type="EnsemblBacteria" id="CCC80026">
        <property type="protein sequence ID" value="CCC80026"/>
        <property type="gene ID" value="lp_2961"/>
    </dbReference>
    <dbReference type="GeneID" id="66450563"/>
    <dbReference type="KEGG" id="lpl:lp_2961"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2471"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_9"/>
    <dbReference type="OMA" id="GFFMDTT"/>
    <dbReference type="PhylomeDB" id="F9US96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2522-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
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        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </location>
        <ligand>
            <name>Manganese</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2F6K"/>
        </source>
    </evidence>
    <sequence length="307" mass="34493" checksum="3E3E5DBB0FF16ECD" modified="2011-10-19" version="1">MSKIDFHTHYLPTSYVEALKRHVPGDPDGWPTPEWTPQLTLNFMRDNDISYSILSLSSPHVNFGDKAETIRLVEAANDDGKSLAQQYPDQLGYLASLPIPYELDAVKTVQQALDQDGALGVTVPTNSRGLYFGSPVLERVYQELDARQAIVALHPNEPAILPKNVDIDLPVPLLGFFMDTTMTFINMLKYHFFEKYPNIKVIIPHAGAFLGIVDDRIAQYAQKVYQVDVYDVMHHVYFDVAGAVLPRQLPTLMSLAQPEHLLYGSDIPYTPLDGSRQLGHALATTDLLTNEQKQAIFYDNAHRLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB1</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="64"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="135" mass="14486" checksum="F249F2F2CEC1F242" modified="2011-10-19" version="1">MDQIMETAVQTVAATAQLETAIATMRKHKIGVLPVMTGDQVVGIITNNDILDAFLNIAGYGQPGIVTRVVVHHDHVGVIFAIGKVLTEHDLSIQTLMVVNHQAEKVIELHVNSEQAADVNQVLTAAGFEVQPVSD</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC80052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008319">
        <property type="entry name" value="UCP031644"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031644">
        <property type="entry name" value="UCP031644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GyrI-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="208" mass="23813" checksum="21568F6A9C0E9DC6" modified="2011-10-19" version="1">MKYEWRKQEKTTYATKKQPQLLTIPAQTFMSIHGTGNPNGPEFQTHLQTLYPAAYGLKHAYKQYAQTQACEFDDYVVFPLEGVWSLTIKGQQLDHLDKDEFSYDIMIRVPDFVPNELIAPALAAVKAKKQLPTEQINVQQFDAMQVAQILHLGAYDDEPASFAKIDELVANQGMHRTSKIHREIYLSDARRVAPDKLKTILRYRVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ6</accession>
    <name>F9USJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102034.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890640.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3080"/>
    <dbReference type="EnsemblBacteria" id="CCC80126">
        <property type="protein sequence ID" value="CCC80126"/>
        <property type="gene ID" value="lp_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3080"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2573"/>
    <dbReference type="eggNOG" id="COG4858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228640_0_0_9"/>
    <dbReference type="OMA" id="KGFIGFF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2619-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="25521" checksum="8850A296C91B98BE" modified="2011-10-19" version="1">MTKIDNDQAQLNQLEQQLTPSDAQYFQDLRLYLLTKELFGSNEKAITRQLLTMLQDFLDASQHGETASQFFGNDPAGLADALLAELPRNSRWQQIHFVGLLILISWFFVILNANTATGFRLNWLLLFAAPLVEIIAIALIFKIMNHAIYADSTPFKQETVPVVLITTLALIMLIGLFLVTPRFGSWVFIFLPNPWGIGLQIIQAIITVSWFGYSLLSNRRQPTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL6</accession>
    <name>F9USL6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3102"/>
    <dbReference type="EnsemblBacteria" id="CCC80146">
        <property type="protein sequence ID" value="CCC80146"/>
        <property type="gene ID" value="lp_3102"/>
    </dbReference>
    <dbReference type="GeneID" id="57026412"/>
    <dbReference type="KEGG" id="lpl:lp_3102"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2592"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_3_9"/>
    <dbReference type="OMA" id="MANGENI"/>
    <dbReference type="PhylomeDB" id="F9USL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2639-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="199" mass="22618" checksum="59CEAFE2742A1D2C" modified="2011-10-19" version="1">MTKTRRRGAELENAIYQAARDILNQDGLEQLTFANVAEQAGTSKPVIYRRWRSPLELAIAAIQDQIITENHGQLDEVSLTGQTLSEDLFQVLKRFTVSINTFNQALVITWFHHLDQQANPEVKDLLNAVKKIDAHAIERVCQRAQQRGELRTGTLSCDLQLMPFDWLRYRAFANEPITDATLHLLVDDLLVPAYQHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP5</accession>
    <name>F9USP5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tkt3</name>
        <name evidence="11" type="ordered locus">lp_3135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642377.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890689.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3135"/>
    <dbReference type="EnsemblBacteria" id="CCC80175">
        <property type="protein sequence ID" value="CCC80175"/>
        <property type="gene ID" value="lp_3135"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3135"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2623"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2668-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="350"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="663" mass="73120" checksum="C764086332B5F30A" modified="2011-10-19" version="1">MSFDEMDTKAVNAIRALSIDMIEHAESGHPGMPLDAAPMAYVTYKKHLRIDPKHPNWPNRDRFVLSAGHSSSMLYAMLYLAGYGITVDDLKNFRRLDSLTPGHPELITPGVDAATGPLGQGLGMAVGMAMASKHLGTKYNVDDIKILNSRVYVIASDGDLMEGISHESASLAGHLKLNNLIVMYDSNDVTLDAQASKTLGDDAGERFKAYGWNYLRVEDGNNLDEIDNALKLAEAEQERPTIIEVKTVLGYGSPHAGENTVHGNPLTAGECRQTMHDLGWDYEPFEVPDEVHQRYAEILQEGQQRYVSWQNELHKLKKVNEELAQNFEVNFSNQAATGDISLQYNAGDTEAVRMTVHKLIQKSAHTPLNFWGGSADLSSSNKTYFENDDGFEPGQYQNKNVFYGVREFAQAAAVNGITLFGGSRTFGSTFFVFSDYMKNAIRMAALQRIPAIFAFSHDSIALGQDGPTHQPVEQLDGLRAMPGLTVFRPADAIETQSVWDYALNKNHGPVVIAMSRQALPVLEGSLKYAKECVKRGGYIVSPSGVSNSDGIIIATGSEVSISIEAQTKLKRQNINVEVVSMPSTELFLQQPKSYRDKVLDPTVRNRMSVEMGSTQSWYRFTGLDGVNIGLDHFGASGPVDEIIQRFGFSSENIAQTYLQHFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ1</accession>
    <name>F9USQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase (GATase1)-like domain protein, ThiJ/PfpI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642383.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3142"/>
    <dbReference type="EnsemblBacteria" id="CCC80181">
        <property type="protein sequence ID" value="CCC80181"/>
        <property type="gene ID" value="lp_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3142"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2628"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_5_9"/>
    <dbReference type="OMA" id="DGFADWE"/>
    <dbReference type="PhylomeDB" id="F9USQ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2674-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="21797" checksum="D610E2C2D8757F95" modified="2011-10-19" version="1">MKTALFLMLDQYADWEASYLASQLNQSTDWQVKTTSTTPLVTSIGGFTTKVDYQLDCLPTIDLLILIGGNSWNINNSLLYSLVQQHLNASKPVGAICGAVDYLAQNGFLTGYQHTGNSLAMWHNYPNYQNSADFHEQQVISDKNLVTANGTAALAFTAAVLQLIHFQSSEELTRTIDLYRLEFYQYCQKYGNPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX3</accession>
    <name>F9USX3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100907.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888218.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0160"/>
    <dbReference type="EnsemblBacteria" id="CCC77704">
        <property type="protein sequence ID" value="CCC77704"/>
        <property type="gene ID" value="lp_0160"/>
    </dbReference>
    <dbReference type="GeneID" id="57026991"/>
    <dbReference type="KEGG" id="lpl:lp_0160"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.129"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="NVFQQCV"/>
    <dbReference type="PhylomeDB" id="F9USX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-126-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="33843" checksum="C32227742DE7B4A1" modified="2011-10-19" version="1">MDKEPLLRISHLQKHFGKFQALKDINFEINAGEVFGFIGPNGAGKSTTIRVLLGILKASGGQATIFGRDVWRDSVAIHKRIAYVPGDVYLWPNLSGGEIIDLFLKLNGGQHTAKTDALIKQFELDPRKKARTYSKGNRQKVALIAALSTDADLYIFDEPTSGLDPLNEQTFQNEVLALKRREKSVLLSSHILSEVEKMCDRIGIIREGQIVETGSLAEMRHLTRTTVDVQTRLPLTDLTTLAGVHGVTARHGDNHVSLAVDADQLTPVVQYLASRKLISLTTTPPTLEDLFMRYYTTEQQPVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT94</accession>
    <name>F9UT94_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tauE2</name>
        <name evidence="6" type="ordered locus">lp_3183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890726.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3183"/>
    <dbReference type="EnsemblBacteria" id="CCC80212">
        <property type="protein sequence ID" value="CCC80212"/>
        <property type="gene ID" value="lp_3183"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3183"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2660"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_5_3_9"/>
    <dbReference type="OMA" id="VLIHFMP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2700-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="216" mass="23788" checksum="1EF5B1738AADE300" modified="2011-10-19" version="1">MVWLLVFLPGLLAGLVQGLTGFGAAIVMMIFLPQLFPIAQSAAVAGVIMAASVITLVWRYHQHIHFRQIIVPFIVYASVAAYSVHLGQVLDVQLLRRLLGALLVSLAGYFSLSKRAANQTYPWWLAGLFMIISGFFNGLFGIGGPLMALYFLSLADTTADYLGNLQTFFLIDVVYISTVRVLNGILTPFLLPHIMIGMVGAVIGRRWRHESCRGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB2</accession>
    <name>F9UTB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface hydrolase, DUF915 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890744.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3205"/>
    <dbReference type="DNASU" id="1061978"/>
    <dbReference type="EnsemblBacteria" id="CCC80230">
        <property type="protein sequence ID" value="CCC80230"/>
        <property type="gene ID" value="lp_3205"/>
    </dbReference>
    <dbReference type="GeneID" id="57026493"/>
    <dbReference type="KEGG" id="lpl:lp_3205"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2678"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003971_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2718-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="30714" checksum="1343C1B60A43F862" modified="2011-10-19" version="1">MKATTKQVLTGATWLVVLLAMIGGTMLWQQQVHKSKPVTTITVTSTERIPMVLLLDDHLTHNQIQQLTAHIQNSSATQTLVTAKITATGTVTFKGQLLNSDNRPYIQVQLPKNLDSNRQTHLLKQLLTAARQQFKFRRFNLVSYGRGGLTATNYVEHTTTSLSPQHLVLMATPFNGASRQSNNRRQTTPVAAKSQTATLAKLIAHRHTIDSKMQVLIVAGKAIKADQPLPLQSALAGQSIFKPVVKVYQQKVLRSWRTQSGLLNNHQIGNTIQTFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH7</accession>
    <name>F9UTH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation (Cobalt-zinc-cadmium) efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">czcD2</name>
        <name evidence="7" type="ordered locus">lp_3288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642507.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890809.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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            <dbReference type="PubMed" id="12566566"/>
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    <reference key="2">
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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</entry>
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    <accession>F9UTU3</accession>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
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        <property type="protein sequence ID" value="CCC77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_0343"/>
    <dbReference type="DNASU" id="1062197"/>
    <dbReference type="EnsemblBacteria" id="CCC77863">
        <property type="protein sequence ID" value="CCC77863"/>
        <property type="gene ID" value="lp_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="57027154"/>
    <dbReference type="GeneID" id="66448439"/>
    <dbReference type="KEGG" id="lpl:lp_0343"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.291"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_1_0_9"/>
    <dbReference type="OMA" id="GFAWFQK"/>
    <dbReference type="PhylomeDB" id="F9UTU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-285-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="31765" checksum="0B14149B81C7C240" modified="2011-10-19" version="1">MFTMFKTIGDQFANFKIIRRMAKYDDRATYQSHYLGLAWEFLNPLIQIGIYYLVFGVALKRGDPMPGIPYLPWMVVGIAPWLYMNKTTLDASSSIYRQVGLVSKMKFPVNVLPSIKIYGNLYSFWTMIAFGIFLMFVNGIWPSVSWIQFIYYFGCMIVLMYSLGIFNATVSVLIRDWHITLQSVLRMLFYMSGVLFNFTTSNFPAVFVRLLELNPFYYVLNGMRESLLNRGWIWQQPNITLTIVFWLFNLVVILTGTYLYNKFRSNFVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW2</accession>
    <name>F9UTW2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888396.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77882">
        <property type="protein sequence ID" value="CCC77882"/>
        <property type="gene ID" value="lp_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0365"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.309"/>
    <dbReference type="eggNOG" id="ENOG50333VI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029844_0_0_9"/>
    <dbReference type="OMA" id="YRVINEY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-304-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="626" mass="71272" checksum="E441E256275C99DB" modified="2011-10-19" version="1">MVIVGGLVSILTVGISYCCYLVKHAGVTNLLTIILSLGCVMATLGLTIMMPGLPEKIGVIGVVILAATMNYLMFWHEKRTAREDDTQFDWIDSGNQHMGFQHIIQNHGEAFAAQGVSQTAIPKLVAKAVNSYHRSGGHFDKWQPYHRVLLTIHYRYRKHLLAVTLSRDQYIISAYPAPLLDKYPRVKKIRIMLEYGCYPIWLYDEKGNLISNDLPQVLRKDATLNKKLLVLQKQYDSLFTNNQHDFSYNGFATAADEQQFLRAFMVIHKDLKRRLGGKYAVLNKITGKVDKVFPTATTVASSQAIPSEAELNSAIVNKPKPVVDKKAKTHVRTYPGLKADLLKVYQNFDIENLGPTYDALVDITKLYRRRFTKYTGQVTLKTVQQSTAKDYILGHTDKNLSEIVANNKDMVAKNIGNAAMCRQVMQLIDIMSRYTLDELCFKCNLARLQLSTTNAHKRLLKTCPDCGAVFVNNKLTNITITGLPANKLQVKMYLRKTGVVSMAAATESIDTTMPKRKIRLFMEWGSSFIWVYNEDNELIKNGLPDELYPDSGLVAKVNVLNRQYSELFTNNGYEFRYNGFKTHEDENAFERDFNAIYEEIAERTRGKYRVINEYYFTSNTEDVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU04</accession>
    <name>F9UU04_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component response regulator PlnC,activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">plnC</name>
        <name evidence="6" type="ordered locus">lp_0417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100999.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888438.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0417"/>
    <dbReference type="EnsemblBacteria" id="CCC77924">
        <property type="protein sequence ID" value="CCC77924"/>
        <property type="gene ID" value="lp_0417"/>
    </dbReference>
    <dbReference type="GeneID" id="57024220"/>
    <dbReference type="KEGG" id="lpl:lp_0417"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.340"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="WSAINDS"/>
    <dbReference type="PhylomeDB" id="F9UU04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-346-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="28642" checksum="C634A7C28A378984" modified="2011-12-14" version="1">MFPIYLLEDNEAQRVEYISIIKNIIMIKEYDMQLVVATGDLQELMNNVMNSKEGLFFLDMEIGEQTQAGLNLADEIRQQLPCAQIVFITTHEELSFLTLERRIAPLDYILKEQGLDDIKQKIVKDIDATQTILKTETVQHKDILGYKIGTRFFSVPINDVIMLSTNKERPGSIRLTAKNKVADFPGNLNSFENKYSQFFRCDKSSLVNIDYVDSYDYQKKELTMIDNIKCSVSYRKSRELNKILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA2</accession>
    <name>F9UUA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643535.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890918.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80404">
        <property type="protein sequence ID" value="CCC80404"/>
        <property type="gene ID" value="lp_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3423"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2853"/>
    <dbReference type="eggNOG" id="ENOG5030UP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165425_0_0_9"/>
    <dbReference type="OMA" id="RNIMPAD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2891-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="14522" checksum="4021E772DA44289A" modified="2011-10-19" version="1">MTNTDNRYYQPTDIKDALQTIQKLFNTYTDAPLTPELMAYHQKLVNQLATNLLPLAQQQHDKLRITQINSMMAVMQDWLKLRLNGQVFGGKMQHFKFVSNQKAQYKRRVHKIRGNQNHRASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH0</accession>
    <name>F9UUH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3504"/>
    <dbReference type="EnsemblBacteria" id="CCC80472">
        <property type="protein sequence ID" value="CCC80472"/>
        <property type="gene ID" value="lp_3504"/>
    </dbReference>
    <dbReference type="GeneID" id="57026717"/>
    <dbReference type="GeneID" id="66450964"/>
    <dbReference type="KEGG" id="lpl:lp_3504"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2920"/>
    <dbReference type="eggNOG" id="ENOG5030A1B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012349_0_0_9"/>
    <dbReference type="OMA" id="MFNIKDE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2960-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="14674" checksum="1142ED1AA40FDB70" modified="2011-10-19" version="1">MFNVKDEHGHYNLWRQTGLALLPLLLAIIAYPLLPNRVYVPTAVTSLTPWGIKSNIFIYPVFCLILWFFIWLFIFFNRLYEKNLKVTRQKYRPMENYYVWSSWVLDILATLMVVVQILVSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI2</accession>
    <name>F9UUI2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system fructose-specific EIIBC component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts31BC</name>
        <name evidence="16" type="ordered locus">lp_3518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102198.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890998.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3518"/>
    <dbReference type="EnsemblBacteria" id="CCC80484">
        <property type="protein sequence ID" value="CCC80484"/>
        <property type="gene ID" value="lp_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3518"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2932"/>
    <dbReference type="eggNOG" id="COG1299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013155_0_0_9"/>
    <dbReference type="OMA" id="ISTWIRP"/>
    <dbReference type="PhylomeDB" id="F9UUI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2972-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="14">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="15">
        <location>
            <begin position="127"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="485" mass="52425" checksum="4802752C4F2777A5" modified="2011-10-19" version="1">MANLKIVAVTNCPAGIAHTYMVAEAIEEKAKSLGYEVHVETQGASGVENKLTPEQIATANYVILALGKGMTDEDKQRFNGKRVVELPVSEALKEIDTLFDNIEDRAEIFTASKVKLGSEQDAVTDGIMSYLMAGVSAALPFVIGGGLLIAIGSMMVQFGMPNTPLAKGVSPSLAWVITSIGNLGFTFMIPIMGAYIAFAIGDKPAFAPAFLVTFLANDTDLLGTQSGAGFLGAIVIGLSVGYFVKYFKKVRLGKNFQSILGFMIIPFVTLLVFGLLTYYLLGPFMGWLMSILLAFLKNIPTSMKIGGGFLVGCMLAFDMGGPINKTAWFFSFSLLSSGIYNWYGIVGVVTLLPPMAAAISTWIRPKLFTKQERAASWSAFLVGMTVATEPAIPYALAAPLPMIAANTLAGGITGAITIMLNVERMAPGIGIFDPLIGLEKPWYWFYLSVIIGLVLNVFFIITFKTAWLRRREKKEQEKLAQVDDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P59441</accession>
    <accession>F9ULC6</accession>
    <name>NANE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nanE</name>
        <name type="ordered locus">lp_3571</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59441"/>
    <dbReference type="SMR" id="P59441"/>
    <dbReference type="STRING" id="220668.lp_3571"/>
    <dbReference type="EnsemblBacteria" id="CCC80533">
        <property type="protein sequence ID" value="CCC80533"/>
        <property type="gene ID" value="lp_3571"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3571"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2979"/>
    <dbReference type="eggNOG" id="COG3010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086300_1_0_9"/>
    <dbReference type="OMA" id="TRPMEIT"/>
    <dbReference type="PhylomeDB" id="P59441"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3021-MON"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179780" description="Putative N-acetylmannosamine-6-phosphate 2-epimerase">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <sequence length="228" mass="24217" checksum="19701BFD90728412" modified="2003-03-28" version="1">MKNTFLNTVKGSLIISCQALPNEPLHSSFIMSRMALAAKGAGAAGIRANSVVDIQAIQDEVDLPLIGLSKVDYPDSPVYITPTIKEMRAVAATGCAVVACDVTGQPRPNGEKLAEIVATMRTEFPDTLLMADTDTIENVKVADKLGFDIIGTTMHGYTPATTGANIADNDFAYLKEVLQATSRPVIAEGKVDTPEKMKRCLDLGCHAVVVGGAITRPLEIAQRFISAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>P77886</accession>
    <accession>F9URI2</accession>
    <name>CARB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Carbamoyl-phosphate synthase pyrimidine-specific large chain</fullName>
            <ecNumber>6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrAB</name>
        <name type="ordered locus">lp_2700</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3416" last="3422">
            <title>In Lactobacillus plantarum, carbamoyl phosphate is synthesized by two carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the arginine-repressed from the pyrimidine-regulated CPS.</title>
            <authorList>
                <person name="Nicoloff H."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
            <dbReference type="PubMed" id="10852872"/>
            <dbReference type="DOI" id="10.1128/JB.182.12.3416-3422.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text>Inhibited by pyrimidines.</text>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text>Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77886"/>
    <dbReference type="SMR" id="P77886"/>
    <dbReference type="STRING" id="220668.lp_2700"/>
    <dbReference type="EnsemblBacteria" id="CCC79821">
        <property type="protein sequence ID" value="CCC79821"/>
        <property type="gene ID" value="lp_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2700"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2260"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_2_9"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="PhylomeDB" id="P77886"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2312-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000145014" description="Carbamoyl-phosphate synthase pyrimidine-specific large chain">
        <location>
            <begin position="1"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 1">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 2">
        <location>
            <begin position="671"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="930"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization domain">
        <location>
            <begin position="402"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain">
        <location>
            <begin position="547"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain">
        <location>
            <begin position="930"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="697"/>
            <end position="754"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="832"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="834"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>PA</original>
        <variation>ST</variation>
        <location>
            <begin position="410"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>P</original>
        <variation>Q</variation>
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>D</original>
        <variation>G</variation>
        <location>
            <position position="862"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>R</original>
        <variation>H</variation>
        <location>
            <position position="992"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91005." evidence="3" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1058" mass="115757" checksum="3A5DEDF82EB60C55" modified="2003-03-25" version="2">MPKRTDIHKIMVIGSGPIIIGQAAEFDYSGTQACLALKELDYEVVLVNSNPATIMTDKEIADQVYLEPITLEFVSQILRKEHPDAILPTLGGQQGLNMAMELSKSGILDELHIELLGTKLSAIDQAEDREQFKALMEELGEPVPASGIARTVDEALAFAKQAGYPVIVRPAFTMGGTGGGIAETPQQLHDITENGLALSPVTQVLIEQSIAGYKEIEFEVMRDAADNAMVVCNMENFDPVGIHTGDSIVYAPVQTLADREVQLLRDAALKIIRALKIEGGCNVQLALDPNSFNYYIIEVNPRVSRSSALASKATGYPIAKMAAKIAVGLHLDEIKNPVTGTTYAEFEPALDYVVCKIPRWPFDKFTHADRRLGTQMKATGEVMAIGRNIEEATLKAVRSLEIGVHHVEEPALRSVDDDVLSDKLIHAQDDRLFYLTEAIRRGYPIDELAELTKINVFFLDKLLHIIEIEQALRTHTDDIETLTVAKRNGFADQTVADYWHETIDQVRDFRLAHKLAPVYKMVDTCAGEFASETPYYYGTYEFENESIVTKRPSVLVLGSGPIRIGQGVEFDYATVHSVKAIQKAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTIEDVLNVIELEKPVGVIVQFGGQTAINLAKPLADHGIKILGTSVADVNRAEDRDEFDKVIKALAIPQPAGDTASDEATALAIADKLGYPVLVRPSYVLGGRAMEIVKKRTDLDYYMHNAVKVSHDHPVLVDSYLVGKECEVDAICDGQTVLIPGIMEHIERAGVHSGDSMAVYPPQSLSAAVQAQIVDYTEKLAIALNCVGMMNIQFVIHDDQVYVIEVNPRASRTVPFLSKVTNIPMAQVATRAILDQSLAEQGYQTGLVTPGPLVHVKAPVFSFSKLNRVDSLLGPEMKSTGEVMGSDVTMAKALYKAFEAAKLHVPSHGNVLLTVRDEDKPETVALAKRFHALGYQLLATRGTATALTTHGLPVTTVDKIDSGERDLLHRMEAGEIQVVINTVSDEEQAENDGTLIRNTSIMHGIPLFTALDTVAAILQVRESQSFVTQAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V23</accession>
    <accession>F9UQI3</accession>
    <name>DAPH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tetrahydrodipicolinate N-acetyltransferase</fullName>
            <shortName evidence="1">THP acetyltransferase</shortName>
            <shortName evidence="1">Tetrahydropicolinate acetylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapH</name>
        <name type="ordered locus">lp_2264</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:13085"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58117"/>
            <dbReference type="EC" id="2.3.1.89"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. DapH subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.89" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641534.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V23"/>
    <dbReference type="SMR" id="Q88V23"/>
    <dbReference type="STRING" id="220668.lp_2264"/>
    <dbReference type="EnsemblBacteria" id="CCC79472">
        <property type="protein sequence ID" value="CCC79472"/>
        <property type="gene ID" value="lp_2264"/>
    </dbReference>
    <dbReference type="GeneID" id="66450021"/>
    <dbReference type="KEGG" id="lpl:lp_2264"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1915"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103751_0_0_9"/>
    <dbReference type="OMA" id="HLEYDRR"/>
    <dbReference type="PhylomeDB" id="Q88V23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1957-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047200">
        <property type="term" value="F:tetrahydrodipicolinate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01691">
        <property type="entry name" value="DapH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019873">
        <property type="entry name" value="DapH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013710">
        <property type="entry name" value="DapH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08503">
        <property type="entry name" value="DapH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03532">
        <property type="entry name" value="DapD_Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000376666" description="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01691"/>
        </source>
    </evidence>
    <sequence length="236" mass="24495" checksum="6DE9985219BB57C2" modified="2003-06-01" version="1">MAKLDAQSIINYIGSAKKKTPVKVYVKGALDQLNVPAGIKTFFSGNAGVLFGDWADVEPFLKANAANIEDYELENDARNSAVPMADLKQYNARIEPGAIIRDQVLIGDNAVIMMGAVINIGAEIGEGSMIDMGAILGGRAIVGKNCHIGAGTVLAGVVEPPSAKPVQIDDDVLIGANAAVLEGVHVGKGAVVAAGAIVIEDVAPNTVVGGVPARKLKDIDDKTKSKTELMAELRNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V89</accession>
    <accession>F9UQB8</accession>
    <name>SYI_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="1">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS</name>
        <name type="ordered locus">lp_2187</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V89"/>
    <dbReference type="SMR" id="Q88V89"/>
    <dbReference type="STRING" id="220668.lp_2187"/>
    <dbReference type="EnsemblBacteria" id="CCC79407">
        <property type="protein sequence ID" value="CCC79407"/>
        <property type="gene ID" value="lp_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2187"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1848"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_1_9"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="PhylomeDB" id="Q88V89"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1868-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000098403" description="Isoleucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="911"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <sequence length="932" mass="106318" checksum="559234B1D9AD149E" modified="2003-06-01" version="1">MRVKETLNLGKTKFKMRGNLPVKEVERQNVWAENKVYEQRQKLNEGKPSFILHDGPPYANGDIHMGHALNKITKDFIVRYKSMNGFRAPYVPGWDTHGLPIEQKLKQAGYDRKKMTDNEFRELCRKYALEQVDRQRDEFKRLGVAGEWDNPYLTLKPEFEAAQVRVFGAFAKRHLIYRGQKPVFWSWSSESALAEAEVEYHDVTSPSAFYGEHVIDGKGVLDDDTYMVVWTTTPWTIPASEGITIDASFDYVVVQPAGENRKFVLAAELLDENAERFGWEDVQVLKTVKGAELENILCEHPFDNSRHLVTMLGDFVTLDSGTGLVHTAPGYGEDDYRIGKQYDLPIFAPVDDKGFLTAEAGDDFAGVFYDDANKIALDKLKAAGLLLKYMPYEHSYPFDWRTKKPIIFRATPQWFASVGDMRDEILKSMDDVEFFPEWGKKRLYNMIRDRGDWVISRQRVWGVPLPIFYAEDGTAIMDEVTINHVADLFGKYGSNVWFERDAKDLLPDGYTNEHSPNGTFTKETDIMDVWFDSGSSHQGVLAERSYLDYPADLYLEGSDQYRGWFNSSLITSVAVSGHAPYKQVLSQGFTLDNQGRKMSKSLGNTIAPADVIKQMGAEIVRMWVASVDTSSDVRVSMESFKQVADSYKKFRNTVRFMLGNTADFDPKANRVAYEDLASVDQYMETRLNEFVAETKDHYDHYDFLDIYKKLINFLTVDLSNFYLDIAKDIMYIDAEDSHSRRSMQTVFYDVLVALTKLFTPMLPHTTEEIWPFLKEPEEFAQLAEMPAVQNYANSDELMAQWTRFMDLRSNVLKALEEARDAKLIGKSLEAHLDLYVDDDTQAFLDHLNTNVRQMLMVSALDLHALSDAPEDAETFGDTLAIKVGHADGDVCDRCRMVKTDVGSDEAYPMLCARCAAIVRENYPESVTTGLEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VH0</accession>
    <accession>F9UQ35</accession>
    <name>APT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">lp_2086</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889838.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VH0"/>
    <dbReference type="SMR" id="Q88VH0"/>
    <dbReference type="STRING" id="220668.lp_2086"/>
    <dbReference type="EnsemblBacteria" id="CCC79324">
        <property type="protein sequence ID" value="CCC79324"/>
        <property type="gene ID" value="lp_2086"/>
    </dbReference>
    <dbReference type="GeneID" id="57025631"/>
    <dbReference type="GeneID" id="66449859"/>
    <dbReference type="KEGG" id="lpl:lp_2086"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1765"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_9"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="PhylomeDB" id="Q88VH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1785-MON"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000149400" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="172" mass="18893" checksum="27DF0773C1C4DAB2" modified="2003-06-01" version="1">MALDLKKYVASIPDYPEPGIIFRDISPLMADGEAYREATDQIVQFARDKHVDMIVGPEARGFIVGCPVAYELGVGFAPARKKGKLPRETVKATYDLEYGQSALYLHKDAIKPGQNVLVTDDLLATGGTISATIQMVEELGGNVVGTAFLVELKELHGRDKIKDYDMLSLMQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ4</accession>
    <accession>F9UQ10</accession>
    <name>RS2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">lp_2055</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640739.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889813.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ4"/>
    <dbReference type="SMR" id="Q88VJ4"/>
    <dbReference type="STRING" id="220668.lp_2055"/>
    <dbReference type="EnsemblBacteria" id="CCC79299">
        <property type="protein sequence ID" value="CCC79299"/>
        <property type="gene ID" value="lp_2055"/>
    </dbReference>
    <dbReference type="GeneID" id="57025605"/>
    <dbReference type="GeneID" id="66449832"/>
    <dbReference type="KEGG" id="lpl:lp_2055"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1740"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_9"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="PhylomeDB" id="Q88VJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1760-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000134183" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="267" mass="30225" checksum="82CD6E1E03698679" modified="2003-06-01" version="1">MAVISMKQLLEAGVHFGHQTRRWNPKMKPYIFTERNGIYIIDLQKTVKMIDSAYNFVKDAAADDGVILFVGTKKQAQDSIEEEATRAGQYYVNHRWLGGTLTNWNTIQTRIKRLKDLKKMEADGTFERLPKKEVSLLMKQRAKLEKFLGGIEDMPRIPDVIFIVDPRKEQIAVKEAQKLNIPIVAMVDTNTDPDDIDVIIPSNDDAIRAVRLITSKMADAVIEGRQGEDEDVTEDSFKDNKDAKKSVDSLEDIVEAVEGDNDAKSDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VS2</accession>
    <accession>F9UPT0</accession>
    <name>SYGA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQ</name>
        <name type="ordered locus">lp_1965</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889733.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VS2"/>
    <dbReference type="SMR" id="Q88VS2"/>
    <dbReference type="STRING" id="220668.lp_1965"/>
    <dbReference type="EnsemblBacteria" id="CCC79219">
        <property type="protein sequence ID" value="CCC79219"/>
        <property type="gene ID" value="lp_1965"/>
    </dbReference>
    <dbReference type="GeneID" id="57025544"/>
    <dbReference type="KEGG" id="lpl:lp_1965"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1659"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_9"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="PhylomeDB" id="Q88VS2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1683-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072845" description="Glycine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <sequence length="299" mass="34538" checksum="EF0312F655C8BCD6" modified="2003-06-01" version="1">MSKKLSVQEIILTLQKFWSDQGCMLMQSYDTEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPENVQDLYLQSLEKLGINPLEHDIRFVEDNWENPSMGCAGVGWEVWLDGMEISQFTYFQQVGGLEVDPVTSEITYGLERLSSYIQDVNSVFDLEWGDGVKYGDIFLEPEFENSKYAFEDSNEELLLMLFDEYEKEAKRQIKNGLVHPAYDYCLKCSHTFNLMDARGMVSVTERAGYLDRIRNMAKSIAKEFVAQREKRGFPLLKHAQEETK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WZ9</accession>
    <accession>F9UNJ9</accession>
    <name>TRMB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">lp_1458</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644279.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889302.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WZ9"/>
    <dbReference type="SMR" id="Q88WZ9"/>
    <dbReference type="STRING" id="220668.lp_1458"/>
    <dbReference type="EnsemblBacteria" id="CCC78788">
        <property type="protein sequence ID" value="CCC78788"/>
        <property type="gene ID" value="lp_1458"/>
    </dbReference>
    <dbReference type="GeneID" id="57025089"/>
    <dbReference type="GeneID" id="66449291"/>
    <dbReference type="KEGG" id="lpl:lp_1458"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1221"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_1_9"/>
    <dbReference type="OMA" id="WRGAKTA"/>
    <dbReference type="PhylomeDB" id="Q88WZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1249-MON"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000171339" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with RNA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="214" mass="24606" checksum="D55FCF8C1D549532" modified="2003-06-16" version="1">MRVRNKPWAPKLIAAHPELITEDPTQLKGRWQSRFAKPQPLQIEVGSGKGQFIIEMAKRHPEINYVAIEIQTSVIAIILKKLVEAPLPNLQLAHADGQAVTAFFEPHEVDRLYLNFSDPWPKSRHEKRRLTYKSFLSSYREVLKPNGQIEFKTDNRGLFEFSLTSMNNFGMQFEQVWLDLHAVATPEDNVETEYEQKFSAAGPIYKIIATFPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW3</accession>
    <accession>F9UMM8</accession>
    <name>RL36_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">lp_1059.1</name>
        <name type="ORF">lp_1059A</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888981.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW3"/>
    <dbReference type="SMR" id="Q88XW3"/>
    <dbReference type="STRING" id="220668.lp_1059a"/>
    <dbReference type="EnsemblBacteria" id="CCC78467">
        <property type="protein sequence ID" value="CCC78467"/>
        <property type="gene ID" value="lp_1059a"/>
    </dbReference>
    <dbReference type="GeneID" id="49393340"/>
    <dbReference type="GeneID" id="57024714"/>
    <dbReference type="GeneID" id="66448970"/>
    <dbReference type="KEGG" id="lpl:lp_1059a"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.894"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_9"/>
    <dbReference type="PhylomeDB" id="Q88XW3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-910-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000126199" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="39" mass="4560" checksum="B6593FFB9111CB7A" modified="2003-06-16" version="1">MKVRPSVKPMCEHCKVIRRKGRVMIICSANPKHKQRQGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YH5</accession>
    <accession>F9UM11</accession>
    <name>PGK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgk</name>
        <name type="ordered locus">lp_0790</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641045.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888764.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YH5"/>
    <dbReference type="SMR" id="Q88YH5"/>
    <dbReference type="STRING" id="220668.lp_0790"/>
    <dbReference type="EnsemblBacteria" id="CCC78250">
        <property type="protein sequence ID" value="CCC78250"/>
        <property type="gene ID" value="lp_0790"/>
    </dbReference>
    <dbReference type="GeneID" id="57024492"/>
    <dbReference type="GeneID" id="66448754"/>
    <dbReference type="KEGG" id="lpl:lp_0790"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.667"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_9"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="PhylomeDB" id="Q88YH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-686-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000145956" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <sequence length="400" mass="42797" checksum="1BD70A88477EF7A8" modified="2003-06-01" version="1">MAKLIVSDLDVKDKKVLIRVDFNVPIKDGKIGDDNRIVAALPTIKYVIEHDGKAILFSHLGRIKSEDDKKGLSLRPVAERLSNLLNKPVTFVPVTEGEQLETAINNMNDGDVLVVENTRFEDVVNGEQVKRESGNDPELGKYWASLGDVYVNDAFGTAHRSHASNVGIASNMDQVAAGFLMEKEIKFLGDAVDNPKHPFVAILGGAKVSDKIGVIDHLISKADKIIIGGGMTYTFYAAKGMGIGNSLVEKDKIELAKSIIEKAGDKLVLPSDSIVAEKFDNDVPSKVVEGSIPDGYMALDIGPKSIEEFEDVLRDAKTVVWNGPMGVFEMSNYAKGTLEIGKFLGTLSDATTIVGGGDSTAAVKQLGVGDKLTHISTGGGASLEYLEGKELPGIAAISEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YY8</accession>
    <accession>F9UL66</accession>
    <name>GPMA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1</fullName>
            <shortName evidence="1">BPG-dependent PGAM 1</shortName>
            <shortName evidence="1">PGAM 1</shortName>
            <shortName evidence="1">Phosphoglyceromutase 1</shortName>
            <shortName evidence="1">dPGM 1</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA1</name>
        <name type="synonym">pgm2</name>
        <name type="ordered locus">lp_0597</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888595.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YY8"/>
    <dbReference type="SMR" id="Q88YY8"/>
    <dbReference type="STRING" id="220668.lp_0597"/>
    <dbReference type="EnsemblBacteria" id="CCC78081">
        <property type="protein sequence ID" value="CCC78081"/>
        <property type="gene ID" value="lp_0597"/>
    </dbReference>
    <dbReference type="GeneID" id="57024376"/>
    <dbReference type="KEGG" id="lpl:lp_0597"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.500"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_5_9"/>
    <dbReference type="OMA" id="ITESHPY"/>
    <dbReference type="PhylomeDB" id="Q88YY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-512-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179886" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="225" mass="25625" checksum="209F01523D298432" modified="2003-06-01" version="1">MTELVLVRHGESTANRDNTYTGWSDVPLTAVGIAQAHQAGKRLRATGLQFGAVHTSVLKRAIVTANIMLSEIDQLWLPEYKTWRLNERHYGALRGQNKDVTRQEYGKAQVQQWRRSFYTVPPLLTPAELDHDRRYTKYGAAVEPRGESLKMAYDRIMPYWIDEIAPRLLDGQNQLVVAHGSTLRAMIKYLEHISDTGIDGVEVANGVPICYHLDRQLHVIGKEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z14</accession>
    <accession>F9UL37</accession>
    <name>NADE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="1">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadE</name>
        <name type="ordered locus">lp_0566</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640900.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888566.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z14"/>
    <dbReference type="SMR" id="Q88Z14"/>
    <dbReference type="STRING" id="220668.lp_0566"/>
    <dbReference type="EnsemblBacteria" id="CCC78052">
        <property type="protein sequence ID" value="CCC78052"/>
        <property type="gene ID" value="lp_0566"/>
    </dbReference>
    <dbReference type="GeneID" id="57024347"/>
    <dbReference type="GeneID" id="66448619"/>
    <dbReference type="KEGG" id="lpl:lp_0566"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.470"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_3_0_9"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="PhylomeDB" id="Q88Z14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-482-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000077568" description="NH(3)-dependent NAD(+) synthetase">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <sequence length="275" mass="30590" checksum="A1C78763ED7949D5" modified="2003-06-01" version="1">MRPLQAEIIKALHVAPTIDPEVEIRRSIDFLKAYLTKNTFLKTYVLGISGGQDSTLAGKLTEMAITEMRQETGDDRYQFIAVRLPYGNQADEADAMAAIDFMQADVTDRVDIQPATDAMVTALEANQLTIHDFNKGNIKARQRMIVQYGIAGEMHGAVVGTDHAAEAVTGFYTKYGDGGADIVPLWRLNKRQGKQMLAALDAPKHLYDKVPTADLEEDRPALPDEVALGVRYDDIDDYLEGRTVSDAAAEKIEAWYLKTAHKRHAAITVFDDFWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z91</accession>
    <accession>F9UU43</accession>
    <name>ISPE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">lp_0460</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z91"/>
    <dbReference type="SMR" id="Q88Z91"/>
    <dbReference type="STRING" id="220668.lp_0460"/>
    <dbReference type="PRIDE" id="Q88Z91"/>
    <dbReference type="EnsemblBacteria" id="CCC77963">
        <property type="protein sequence ID" value="CCC77963"/>
        <property type="gene ID" value="lp_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="57024258"/>
    <dbReference type="KEGG" id="lpl:lp_0460"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.380"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_9"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="PhylomeDB" id="Q88Z91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-384-MON"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189226" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="288" mass="32024" checksum="7DD4AEEB762C11E8" modified="2003-06-01" version="1">MQIVEKAPAKINLGLDTLFEHPNGDKEWDMVMTSVDLADYVMLESLHTNRIEVVTDSGFLPNDRRNLAFQAVSVLKRYCHVDRGVRIKIRKAIPVAAGLGGGSSDAAAVLRGLNRMWNLHLDLATLARLGLQVDSDVPYCVYSQTAHVTGKGDVVTPLPKLPPMWIILAKPKVSVSTPNILRQVNYERIDQHPNIEALLAGIQQQDFAEIFANMGNVLEPITAKRYPEILQIKRQLLTFGADAAQMSGTGPTVFGVCRKQSRAQRVYNSLKGFCREVYLVRPVNLNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV2</accession>
    <name>F9UKV2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pur operon repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purR</name>
        <name evidence="7" type="ordered locus">lp_0466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642030.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0466"/>
    <dbReference type="EnsemblBacteria" id="CCC77967">
        <property type="protein sequence ID" value="CCC77967"/>
        <property type="gene ID" value="lp_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="57024265"/>
    <dbReference type="GeneID" id="66448540"/>
    <dbReference type="KEGG" id="lpl:lp_0466"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.384"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088227_0_0_9"/>
    <dbReference type="OMA" id="YMLERPR"/>
    <dbReference type="PhylomeDB" id="F9UKV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-388-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045982">
        <property type="term" value="P:negative regulation of purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015265">
        <property type="entry name" value="PuR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010078">
        <property type="entry name" value="PurR_Bsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF2">
        <property type="entry name" value="PTHR43864:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09182">
        <property type="entry name" value="PuR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01743">
        <property type="entry name" value="purR_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PuR_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="30564" checksum="B2DE7935134A9B1F" modified="2011-10-19" version="1">MKVRRSERLIDMTRYLLERPHTLVSLTYFAERYASAKSSISEDLTILKKVFQARGTGILETIPGAAGGARFIPYILKEEAQEFIDEMTTKVADKSRVLPGGYVYLSDILGQPDILRQVGRVIATQYLNQKIDAVMTVATKGIPIAQSVATYLNVPFVIVRNDSKITEGSTVSVNYVSGSSERIKKMELSKRSLTEGANVLIVDDFMKGGGTINGMKTLIEEFDANLIGITVFAEASFVGNRLIDDYTSLLRVTNVSDSDKAIKVVAGNYLEKVFGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL13</accession>
    <name>F9UL13_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">lp_0539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888542.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0539"/>
    <dbReference type="EnsemblBacteria" id="CCC78028">
        <property type="protein sequence ID" value="CCC78028"/>
        <property type="gene ID" value="lp_0539"/>
    </dbReference>
    <dbReference type="GeneID" id="57024314"/>
    <dbReference type="KEGG" id="lpl:lp_0539"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.446"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_9"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="PhylomeDB" id="F9UL13"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-449-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="634"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="809"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132215" checksum="8B2B1E71B3087C58" modified="2011-10-19" version="1">MDIETIVEQTPDFQTILAGISPRSRQLITGLNGSARTVYLSALFHQLTHSLLIVTDNGFHASQLVDDLTSLLDEDQVFLFPAEEMIATEVATSSPESRAQRVQALNALLRDSPAVVVTSVAGARRFLPPVAQFQAATLPVAVGQDIDLEDLQRQLHDMGYVKEKLVARPGDFAVRGSIVDIYPLDADYPLRLDFFDTEVDTLKYFDPETQRSVENLDEYTILPATDFILTSAMLQAGAQRLKTAIAAENKKLKPAERQTLADNLAQPLADMEKGIIGNDLLLYGDYLYDRKTSIFDYVAADGLVIFEEYSRLLDSEQQLLTQEADWVTDQLAHHRVLATASYGNDIRDLLRDDQHAQLLISLFQKGIGNVKLAQVTNVRTRPMQEFFGQLPALKTELDRWHKLKQTVVLMVSEAERLTKVSDTLDDFEIEAVMTKATNLQPGAVQIVQGSLQNGFEFPDGKLVIVTEQEMFKKVAKKRPRRQTLANAERLKSYTDLKPGDYVVHVNHGIGKYVGMETLEVDGVHQDYITIAYQNNAKIFIPVTQLNLVQKYVSSESKTPRINKLGGTEWTKAKRKVAAKIEDIADELVDLYAKREAEKGYAFPPDDSYQDDFDNDFPYPETPDQIRSINEIKHDMERPKPMDRLLVGDVGYGKTEVALRAAFKAIEAGKQVAFLVPTTILAQQHYETMLNRFEGYPINVGMLSRFRTTKEMKETVQQLKSGEIDIVVGTHRLLSKDVAFADLGLLIIDEEQRFGVKHKERLKALKASVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPTNRYPIQTYVMEQNFGVIKEGIEREMQRNGQVFYLHNRVHDIDKVVAQIKDLVPDAAVAHIDGQMPESQLEGILYDFIRGEYDVLVTTTIIETGVDIPNVNTLFVENADRMGLSQLYQLRGRIGRSSRVAYAYFTYQQNKVLTEVGEKRLQAIKDFTELGSGFKIAMRDLSIRGAGNLLGKQQHGFIDSVGYDLYTQMLSEAVAKKRGQAAKVKTDATVELGIEAYLPTSYIEDERQKIEIYKRIRQLENNDQYMEVQDDLMDRFGDYPVEVAGLLAVGKLKLLADDALIEKIQRDDSELHLTLSKQGTAKLDTKDIFKALAKTKLKATVGIDDDKMKVKLVIQPKMQQDEWLAQLTQFVEQLSLILAEDDVASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL24</accession>
    <name>F9UL24_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Di-/tripeptide transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dtpT</name>
        <name evidence="12" type="ordered locus">lp_0551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643855.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0551"/>
    <dbReference type="EnsemblBacteria" id="CCC78039">
        <property type="protein sequence ID" value="CCC78039"/>
        <property type="gene ID" value="lp_0551"/>
    </dbReference>
    <dbReference type="GeneID" id="57024332"/>
    <dbReference type="KEGG" id="lpl:lp_0551"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.458"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_1_9"/>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="PhylomeDB" id="F9UL24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-467-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="11">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="490" mass="53902" checksum="24DD5A50E96F4588" modified="2011-10-19" version="1">MDKEQKLDRSFFGQPRGLRTLFFTEMWERFSYYGMRALLIYYMYYSVAKGGLGFDQVTAASIMSIYSALVYVSSVLGGFLSDRVWGSRKTVFIGGVFIMLGHIVLSTPFGVGALFVSIALIVIGTGLLKPNVSDMVGQLYTVEDTRRDAGFSIFVFGINLGSLVAPALVGRIGLNVNFHLGFSLAAIGMFFGLLQYYFDGKKNLSSASLYPTDPLEPGDLKKIMRWTILGIVGIGLILLLMQLMNALTLANVISLISTLVILTPIVYFILMLTSDKTNATERSRVRAYIPLFIAAALFWAIEEQGSSVLALFAANRVNLDLGFTHLAASDFQMLNPLFIMIYTTPFVWLWTKWGKKQPSSPTKFAIGLLFAGASYLVMAVPGALFGTAGKVSPWWLVASWAVVEIAEMLISPIGLSVTTKLAPKAFASQMMSMWFLTDSVGSALNAQIVRFYSTQTEVPYFAITGIVSVVLGIILFMMVPMIKRSMQGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL57</accession>
    <name>F9UL57_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system, mannose-specific EIIB component</fullName>
            <ecNumber evidence="9">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pts10B</name>
        <name evidence="9" type="ordered locus">lp_0587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0587"/>
    <dbReference type="EnsemblBacteria" id="CCC78072">
        <property type="protein sequence ID" value="CCC78072"/>
        <property type="gene ID" value="lp_0587"/>
    </dbReference>
    <dbReference type="GeneID" id="57024367"/>
    <dbReference type="GeneID" id="66448634"/>
    <dbReference type="KEGG" id="lpl:lp_0587"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.491"/>
    <dbReference type="eggNOG" id="COG3444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116175_1_0_9"/>
    <dbReference type="OMA" id="IYLDERF"/>
    <dbReference type="PhylomeDB" id="F9UL57"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-503-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
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    </dbReference>
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        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
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        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="18595" checksum="2146C375348E1F22" modified="2011-12-14" version="1">MTMDIRLARIDSRLLHGQVATVWTKTVSPNRILVVSDEVAQDALRKILIVQAAPPGVKANVITVDKMIEIYQDSLFDEVKPLILTDTPQNMARLVAGGLDFSKTGIDIGSLAFSAGMVMVTNAIAIGQAEARALYALQAAGLKVFAQKVPTDKRVDVMPLLAKNGFMAPDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG2</accession>
    <name>F9ULG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase-like (Promiscuous)</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3608"/>
    <dbReference type="EnsemblBacteria" id="CCC80569">
        <property type="protein sequence ID" value="CCC80569"/>
        <property type="gene ID" value="lp_3608"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3608"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3012"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_3_9"/>
    <dbReference type="OMA" id="QVHAVNI"/>
    <dbReference type="PhylomeDB" id="F9ULG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3056-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="38190" checksum="93A642D2CB6F2433" modified="2011-10-19" version="1">MDKSTKITSQNITIGIIGMGRIGNVHYKNLMRIPNVTVKYICDLVATEEWTTKYKAADHIVTDYHDVLADSEVEAVLICVPTDLHPQITMEAAEAGKDIFCEKPVGFDDHDILKALDTVKRCGVKFEVGFNRRFDKNFRRIVDHRINGDIGDEQILKITSRDPEPPSLDYINHSGGIFMDMTIHDFDMARYITDAEVDQVYVTGNVLVDPKIGSAGDIDTAIINLSFNNGMIGVIDNSRQAVYGYDQRIELFGSKGMAHADNVVDSTTTYSGEKDVSGDKPMFFFLQRYIDAYRDEIESFLDAVRGNHEIECTFEDGIKAIRLAQAAKKSLETGQPATVADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN1</accession>
    <name>F9ULN1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888634.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0642"/>
    <dbReference type="DNASU" id="1061800"/>
    <dbReference type="EnsemblBacteria" id="CCC78120">
        <property type="protein sequence ID" value="CCC78120"/>
        <property type="gene ID" value="lp_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0642"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.536"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052538_0_0_9"/>
    <dbReference type="OMA" id="MAVYQEL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-553-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024432">
        <property type="entry name" value="Put_RecE_PDDEXK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016974">
        <property type="entry name" value="Uncharacterised_phage-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12684">
        <property type="entry name" value="DUF3799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031475">
        <property type="entry name" value="UCP031475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3799" evidence="3">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="286" mass="32613" checksum="9D5FEBEADA4563ED" modified="2011-10-19" version="1">MIKNLSKAKSTSKTSSTTSETLTPANYYDRWTDQSFMSATWFKKFLACEAEALAELTGKWQPVRDAKALVVGNWLHSYFESKQAHEKFKDEHPESISKRGPTKGQLKSDFKVANAMIQSLTNDHDFNLLYQGDKEVIVTGEIGGYPWKGKIDCLNLKQGYFVDLKTTADIYKVYWNPETREKESFVYAYNYPLQMAVYQELIKQQFGVTCKPYIVAVSKQDPPDKQAIDLPEYRLTNAMNQVLESQQHLQDIIKGEADPIQCGHCAYCRSTKKLESVVSADDLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM43</accession>
    <name>F9UM43_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101168.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0825"/>
    <dbReference type="EnsemblBacteria" id="CCC78282">
        <property type="protein sequence ID" value="CCC78282"/>
        <property type="gene ID" value="lp_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0825"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.700"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_0_3_9"/>
    <dbReference type="OMA" id="LHYDSID"/>
    <dbReference type="PhylomeDB" id="F9UM43"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-718-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22474" checksum="6E160769941E1610" modified="2011-10-19" version="1">MPATDLRVQRTQTALKKAFRTLALKYPRYRDITVKELTSVANINRKTFYLHFDSIDDLAETFVQEGADKILALIDPQDFKKNISQPGLIFDRLVTYFRQSEAFHRVILLNDDYSFLSRKIHAAVVAGLTTTIQTNYHLSAIDAKVCSSFLIHNNLTFFRLYFNGDLGLTLAELKQRLVSLNTYGIHQFFYPNQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM77</accession>
    <name>F9UM77_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gmk2</name>
        <name evidence="2" type="ordered locus">lp_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101185.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0866"/>
    <dbReference type="EnsemblBacteria" id="CCC78316">
        <property type="protein sequence ID" value="CCC78316"/>
        <property type="gene ID" value="lp_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0866"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.736"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_9"/>
    <dbReference type="OMA" id="QLHFFEH"/>
    <dbReference type="PhylomeDB" id="F9UM77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-752-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="193" mass="21692" checksum="B94E00804821E869" modified="2011-10-19" version="1">MTTKRIFVITGPTGSGKTTVSHYLRSQYQIPQVITHTTRAPREGEVGGRDYYFETPASFVTKHYLEHVTYSGNQYGSSREGLAAAWERSPLISIVLDTAGAITYARELGEQAVVIYLEVADQEALIQRLTKRGDLPSRIKKRVASDEYLRDQALPVGLVGHAHVIVNDDWQATRRQLDELVTEYCQHDVVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD5</accession>
    <name>F9UMD5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="11">R protein</shortName>
            <ecNumber evidence="11">3.1.21.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Type-1 restriction enzyme R protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hsdR</name>
        <name evidence="13" type="ordered locus">lp_0938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888888.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0938"/>
    <dbReference type="REBASE" id="6998">
        <property type="entry name" value="LplWORF939P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78374">
        <property type="protein sequence ID" value="CCC78374"/>
        <property type="gene ID" value="lp_0938"/>
    </dbReference>
    <dbReference type="GeneID" id="57024615"/>
    <dbReference type="KEGG" id="lpl:lp_0938"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.796"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004848_1_0_9"/>
    <dbReference type="OMA" id="FTMNWAK"/>
    <dbReference type="PhylomeDB" id="F9UMD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-810-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022625">
        <property type="entry name" value="TypeI_RM_Rsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12008">
        <property type="entry name" value="EcoR124_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="250"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="957" mass="110792" checksum="1B700CAC3DA4824A" modified="2011-10-19" version="1">MMASGHQSEAELENHLIRKLQSIGYHYVEIPDVETLNTHFRAVLSERNQERLKGTPLSDREFQAVLNDLIGAKTHYQVAQILRGSVVQPTGKINIKRDDDSSLYLEIFNGKQFDQNIFEVSHQMTVEGRHENRYDVLILINGMPIAQIELKRQGVEFTQAFNQIIRYRTESYAQAKLMRLVQVFVISNGNETRYFANGDGELNSNFMFYWTDEHNNWLNDLDAFTTTFLSKPRLHSLIAKYTVFDSSDHKMLLMRPYQIYATEAIIKQAIDHPHENGYVWHTTGSGKTITSFKASQLLLQETDAEKVIFMIDRADLDIQTVKNFSAYLPETTGGQSPLDRTDNTAALVKQLSSNDNGLIVTTIQKMNNAVSNDRYKDILTPYHDRKVIFIEDESHRSQMGEMRKNVNHWFKNAQHFGFTGTPIFQQNMGPDGRTTKDLYGNQLHQYLIRDAVRDGNVLGFSIQYLSTFEETDHDITDEQVPGIDTQEVYESEERLTKIVEHILLNHSHITKNKHYNAIFTVANTRMALKYYQLFRKLDPDHNLKVTTIFTWAANEDDNEEHQKQDDVTSRMGLDQVVKDYNQMYGTDFSTDKFKDYFADVSKRMRDHNDQTPTDNIDILIVVNMFLTGFDSKRLSTLYVDKNLQWHGLIQAFSRTNRVEGKQKPFGNIIAYRNIKNKTDEAVALFSDGDSSGFLAPDYDELKAEFTDKIGQLLTVTPDVQSVDDLYNRGDDALYEFVMAFRAVLRVYNRIRVYDDFEWAQYEPEFSDQLMEAFRGKYFTAYQTIYQRKTQERVSILDDVDFDISLLETDTINVDYIVNLISGIDLMSSTERKQDIQKIEHLLDNATNDQLKSKVELLEQFLNEVLPTLDTDDDIGMSLSNFMAESQRAAIKGFSQEHHLSEDFVNEQISDYNFYGKTKDKEIIDKLSANGLGFREKRQAKREIKDFVSTIDRKYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMF3</accession>
    <name>F9UMF3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepD3</name>
        <name evidence="6" type="ordered locus">lp_0959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0959"/>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="CCC78392">
        <property type="protein sequence ID" value="CCC78392"/>
        <property type="gene ID" value="lp_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0959"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.816"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_4_1_9"/>
    <dbReference type="OMA" id="DLTYSHE"/>
    <dbReference type="PhylomeDB" id="F9UMF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-828-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="468" mass="52360" checksum="4997B25A38ED3F7D" modified="2011-10-19" version="1">MEKRIKGSCTTILVGKKASIDGSTIISRNDDGHEALDPERLVVVNPADQPRHYQSVISKVEVDLPDNPLRYTSIPNSILTNGTWPAAGINSENIAMSATETITTNSRILGIDPFVAGGIGEEDLCTLVLPYIHSAKEGVTRLGALLEQYGTYEPNGIAFSDQDEIWWLETIGGHHWAAKRIPDDAYVVAPNRMNIDDFDFNADDTLASADLEQLIEDYHLNPDFDRVNLRHIFGSASIKDTVYNNPRAWFGQKYFTPDVVQDPMEQDLPFICHANRKISIEDVKFVLSSHFENTKYDVYGSGSEADKTLFRPIGINRNHDVHILQIRNNVPAAVAGIHWLAFGANTFNTVVPFYANVNDTPASYKDADGTFNLNHMYWLSCTTALLGDTDYDFYVDMRNSYELEAMSAYRKIENDTDADLANHQDVTAYLETANQQLADTAMKLQTKLLGDMVIAGSEKMKLRYNLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG5</accession>
    <name>F9UMG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101235.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888918.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0971"/>
    <dbReference type="EnsemblBacteria" id="CCC78404">
        <property type="protein sequence ID" value="CCC78404"/>
        <property type="gene ID" value="lp_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0971"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.827"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="WLTEPAW"/>
    <dbReference type="PhylomeDB" id="F9UMG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-840-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24510" checksum="2D8B92D4989ECD1F" modified="2011-10-19" version="1">MQIYFIRHGRTQYNLEHRFQGGRADSPLVASGIDGAKAAGDYLRTTQFSAVYSSPQQRALDTAKYIVAANQWQPPIQIDDGLREFDFGDWDGKQEAEVQPQSYAQVIFTKPAEYRPELAGGGESYADFVTRTTSTLHRLIDQVGVASTQPLLIVSHGLVTTMTVKALMGVPVAELRAPFVVDGQVMKTVGHGIVDNDSLTVLSTTDNQHFELTTWNETGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMN5</accession>
    <name>F9UMN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase component I</fullName>
            <ecNumber evidence="2">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hepA</name>
        <name evidence="2" type="ordered locus">lp_1067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.30" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641270.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1067"/>
    <dbReference type="EnsemblBacteria" id="CCC78474">
        <property type="protein sequence ID" value="CCC78474"/>
        <property type="gene ID" value="lp_1067"/>
    </dbReference>
    <dbReference type="GeneID" id="57024720"/>
    <dbReference type="GeneID" id="66448976"/>
    <dbReference type="KEGG" id="lpl:lp_1067"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.901"/>
    <dbReference type="eggNOG" id="COG4769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108933_1_1_9"/>
    <dbReference type="OMA" id="LYIIEGM"/>
    <dbReference type="PhylomeDB" id="F9UMN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-917-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="20556" checksum="97E8D0922F3F0105" modified="2011-10-19" version="1">MNNSFERSNKTHRNIYIALLVAQGVIIGILERMIPFPFAFAPGAKLGLANLITIVAIYTLSLTDVITLTWLRLILTALLGGTLSTFLYSFGGAFLSLFAMLLVKQLGPKRVSIIGISATGGVMHNVGQLLVASLIAQTWTVMLYLPVLSIIGLAAGSALGIAANYLFTHVTILRYLKFNREHHPDQTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS8</accession>
    <name>F9UMS8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641320.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1120"/>
    <dbReference type="EnsemblBacteria" id="CCC78517">
        <property type="protein sequence ID" value="CCC78517"/>
        <property type="gene ID" value="lp_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="57024765"/>
    <dbReference type="KEGG" id="lpl:lp_1120"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.947"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_9"/>
    <dbReference type="OMA" id="WFAKTHP"/>
    <dbReference type="PhylomeDB" id="F9UMS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-960-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="475" mass="50781" checksum="519080BCB1AB6F64" modified="2011-10-19" version="1">MKASQRLLVKKSVNPANFNKGGLEKTLSAFSLTMMGVGAIVGSGIFITPGIIAAKYAGPAAMLSFVIAAVVCSLAALCYAEFSSTIPLAGSAYTYVYTVFGEFLAWILGWSLISEYLFAVSSVAVSWSSYFQNLMSGFGLKLPTFLTAAAGTAGVSGAGFNLIAFVVVLAVSLLLVGGLQESTRVNSIMVIVKILVIVLFIGVAIFFVKPANYHPFMPHGVSGLVKGASLAFYAYIGFDAVSTASEEVKNPKRNMPIGIVGSLVVASILYVAMAAVLVGVVHYSKLNVGDPVAYALAVIHQNWAAGIVSLGAVVGMTTVLIVMLYGGTRLLFAISRDGLLPKVFRTVSPHTKVPVKSTWIFGIIASVFAAVIPLDKIAELVNIGTLFAFAMVSIGVVFLRRHETLQQINSSFKVPFYPVLPVVSFLACVYLMLNLQAFTWHMFGIWLVIGIVIYFAYSYRHSRIRAGLRAKESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT1</accession>
    <name>F9UMT1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface hydrolase, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889034.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1124"/>
    <dbReference type="ESTHER" id="lacpl-LP.1124">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="DNASU" id="1063284"/>
    <dbReference type="EnsemblBacteria" id="CCC78520">
        <property type="protein sequence ID" value="CCC78520"/>
        <property type="gene ID" value="lp_1124"/>
    </dbReference>
    <dbReference type="GeneID" id="57024767"/>
    <dbReference type="KEGG" id="lpl:lp_1124"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.950"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322581_0_0_9"/>
    <dbReference type="OMA" id="DYSDQET"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-963-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="421"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="901" mass="94673" checksum="1E986AC0CDEC2096" modified="2011-10-19" version="1">MKRNSQQSTTVDHYKMFKDGKHWVYAGITIAGLGSTLMLTTNALAATATPVSATTTSAANAPASVASQLSQAAGATATESTTTSSMTTGEDSNTTSNTDSSATTDTNQITTSTNATETSATEQATSAASATDQASEVANSASGTVTSQTTSATNSTAANTISGNEQAASSATSDATQVTDMVTATTKSTTDSAIDSTDDTSTNTNSTAAATPTSVATTSAASAATSDSGHGLIYETNDTTGNQKSTVTITQSGPYSVTWKKVTTSDKTDTTTVTLDASDIVAVVNTIKDLANQAATPSGKEQLAAAKAKLTTILDELKELPTDIASTIVGNVLYPIVFTGTGSEALSNLRTEMNQHRYDISNTWTGLDPVAYAADRAAAEEYYPTTVTWWDNVTKETWTLPEYNDPTQSVRAYYIQNGDSTKTVIIGQGWTEHVDWIGYVSKIWYDMGYNVLMPSQRGQFLSDGDNLTFGYQDKYDWLNWVKMVDERNGADSQVVFYGQSLGADTVLEAASVPGLSKSVKAVVSDAGYATLPELGSSLYNKAITAVSNALQSIGLPAITSLPFLSYDKIVAAMNARLIKEQGFSVDDLSATDAASKITIPLLLIHTQDDAFIPYTQSLELAAANHSANQEVWILPGTVGGHAAANNAILQYRQHLLAFLTPLLSVADAEDEAVDVDQVTDNRNQGAADNGTTTDSTAQDNVTDETTADEAISDHQTIVDNTTTDTTNITSDTTPDTTNHAKPNDDSTTSYVDLNDTDNAVDNDSDTAVDATRATTTVNQTSTIDQSSVIKGQVSDSIMVSSNATTNTDWLVNHDDSGSAVTASLLQDYSDQEASVTTPATVSATTTNTDSADLVAVSSPASKATTELPQTDETTQSWLATLGTSLLALATGIWAQVRRRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV9</accession>
    <name>F9UMV9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular protein, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641352.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1159"/>
    <dbReference type="EnsemblBacteria" id="CCC78548">
        <property type="protein sequence ID" value="CCC78548"/>
        <property type="gene ID" value="lp_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="57024794"/>
    <dbReference type="KEGG" id="lpl:lp_1159"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.979"/>
    <dbReference type="eggNOG" id="ENOG5033ARR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164577_0_0_9"/>
    <dbReference type="OMA" id="NYDVYLD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-990-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032254">
        <property type="entry name" value="DUF4828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16110">
        <property type="entry name" value="DUF4828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13550" checksum="E24D7E270228ACDA" modified="2011-10-19" version="1">MKRRGAILFGLSLLAGLSSTLLHKRHPSTIADGDLAVFYAGTWTYRDEAHHRDHTLEIDPNMMIRIDGRSVPATVESISSSALVLLDQYGFHLEVRANEQRPVTLFDEADDRSYVILSPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX5</accession>
    <name>F9UMX5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cps1A</name>
        <name evidence="1" type="ordered locus">lp_1177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1177"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78564">
        <property type="protein sequence ID" value="CCC78564"/>
        <property type="gene ID" value="lp_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1177"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.995"/>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068623_0_0_9"/>
    <dbReference type="OMA" id="IWQYWGQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1007-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="330" mass="38501" checksum="B11F846B76C9D810" modified="2011-10-19" version="1">MGVETLNKVFKIAKKFYTDIRYYSFQLACIHLGETFSRYTKFNLADKYYLKKDKIVLNYLRTRYTNSPKQDVYGGVPKIYQPIWVFWYQGEEQMPKLVSACLKSVRNNANGHEVILISKENMNNYIEIPDVIRDRVESKKISMAQYSDIIRMCLLAEYGGLWIDATVLVTQLIPQYIFELPLFTIKNSPNQEDPLYFISVSHLRWTTYVMGGEPNNALFTFVRDLLIEYNSVENALIDYLLIDYAIELAIEKNSSISDDMIKIPINNQLKEEFVHRLFSVYPDCKTKELLQSGTIFFKLSYKKVAPKVIEKNNYQLLVDGDLCQAYNMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY5</accession>
    <name>F9UMY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101290.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1187"/>
    <dbReference type="EnsemblBacteria" id="CCC78574">
        <property type="protein sequence ID" value="CCC78574"/>
        <property type="gene ID" value="lp_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1187"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1005"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639033_0_0_9"/>
    <dbReference type="OMA" id="IWEIWNE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1017-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388861" evidence="1">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="429" mass="48985" checksum="DCF8F38F5D8EDD44" modified="2011-10-19" version="1">MKKKVYTWILISVVLLSCTALVIANQHRLQSSQATNRQAVLTANKPLTDKVGGFVWLYGYKKGSTRNRDYIKSQVIAAHSTHLHYVVISILFNNKYVNKGKFDFEEFDFAMKTIKENGLVPIVVFSSNDSVDANEYAKNKRAVLNKYERLIRSVIIKYRDHGVIWQMWNEPNGLFWFNQSNSGTNAAQVRTWVDFNAKIFAYVRRYDPNSVFLAGAIAGNYSDSKQDMRLAIQNHITKYGDALANHPYLSSSYPDNGAPENLLKLNSRKFLLSLTADNSKKAVRSIPLVTTEMGYSMSKSHFGSWSEEDQANYLARSIFVLDMMHQPIISLYALVDEKNGSGEWGLYKGMSPHYVSKQSARLISQLLSNLDGYSFDERLHSDTRDFVLKYKKNGQRDRIVCWTMDDDHVLKVSGQTVLVTKTPQIVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN21</accession>
    <name>F9UN21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3J</name>
        <name evidence="2" type="ordered locus">lp_1227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101322.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889124.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1227"/>
    <dbReference type="EnsemblBacteria" id="CCC78610">
        <property type="protein sequence ID" value="CCC78610"/>
        <property type="gene ID" value="lp_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1227"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1040"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065769_1_0_9"/>
    <dbReference type="OMA" id="WKNCHAD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1051-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025536">
        <property type="entry name" value="DUF4422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14393">
        <property type="entry name" value="DUF4422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4422" evidence="1">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="30402" checksum="CB62070A633DC893" modified="2011-10-19" version="1">MKVQIYVAAHKPYQMPQDPTYRPIFVGAAIHGGAPQNYQPDNVGDNISASNPNFNELTAMYRIWKNCHADVKGLNQYRRYLSEAPKRKLAGILSMTEIESLLQQYDVIVPKKRHYYIESNYSHYVHAHHREPLDMMRTVISERHAAYLDDFDQLMHQTSAHMFNMMIMAGPKFDDYAKWVFDILFAVRDRIDIADYDVQEARVFGYLSEFLLDVWINHNQLKYVEVPVMYMEKQQLPAKAYNLLKRKFFPQAAKRTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN24</accession>
    <name>F9UN24_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889127.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063040"/>
    <dbReference type="EnsemblBacteria" id="CCC78613">
        <property type="protein sequence ID" value="CCC78613"/>
        <property type="gene ID" value="lp_1230"/>
    </dbReference>
    <dbReference type="GeneID" id="57024853"/>
    <dbReference type="KEGG" id="lpl:lp_1230"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149278_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UN24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1054-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16965" checksum="09F3BAE1AA6324E5" modified="2011-10-19" version="1">MLNHQQIKAQFESLETLQSIQKQVHQMSIQGLVTTGISMREWEVLVYLEQHEQASASELAKVFKVTRTLISRNTWHLIQDNLIQPQIDQSDRRIVWLSLTTTGQETIGKVARQIQANLQAFDCNHELATLMKQLRYLKQQLIILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN70</accession>
    <name>F9UN70_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine/pyrimidine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1290"/>
    <dbReference type="EnsemblBacteria" id="CCC78659">
        <property type="protein sequence ID" value="CCC78659"/>
        <property type="gene ID" value="lp_1290"/>
    </dbReference>
    <dbReference type="GeneID" id="57024915"/>
    <dbReference type="KEGG" id="lpl:lp_1290"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1091"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782333_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1117-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="357" mass="37084" checksum="DF6F1C5FD11910DE" modified="2011-10-19" version="1">MHWLADLLAAIGVVLNGIPQGIMAMSLGFAVFPTAFSFGLVGLINGVASSVAPVSFQAESLALVGHLGHDLRERSSIIFLGASLMFVIGLTGTLPLIVHSLGNQLMAAMMAGVGLMLAKIALQMAHEQPQFGWLSIGLAGVTYLISKDLVWTIAVSVIGTSCYAATTHYRVALPEHVTTRKLQFVRPQFSFKILRGALSLACLNIGANLSYGLITGQMTGQHPNPVNLNLLTSSQALADLGTSLLGGAPVETIISATASAPEPVIAGILMMLIMMLILLLGWLPKLGKVVPSTAIAGFLFILGTIVIFPENATTALHGSLSTVAGVTLVVTALVDPFAGLMTGALLKFGLPLIGLGL</sequence>
</entry>
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    <accession>F9UN83</accession>
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        <submittedName>
            <fullName evidence="1">Glycosyl transferase, group I</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101347.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1310"/>
    <dbReference type="EnsemblBacteria" id="CCC78672">
        <property type="protein sequence ID" value="CCC78672"/>
        <property type="gene ID" value="lp_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1310"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1104"/>
    <dbReference type="eggNOG" id="COG4627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032113_0_0_9"/>
    <dbReference type="OMA" id="IFAVCEY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1130-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="544" mass="62856" checksum="A35AEEDB74443047" modified="2011-10-19" version="1">MQKSTVTKLKQALIATGNLKDYGTSTVTLALSVSDHRHRAQVRFYRCDSFKQAWIAVAQQLAKTPQASWVRLEAVQSTQKLPRETFEKRLAATFRMNYWRYGISFDADFKTALLEMESNGQAFFRPSKAHRIGKNRSGSWVDYDRVEPYLNKREGALPVDIRKTENVWVFTTAGVFTDGQKIWNLSEQEDCGKGVRVVTDEQSELQSAIEHGETFLINQLKDNGKFVYGYFPARQRVLSNYNVVRHFSSLYALLEAIPFTKRTENCAKVKLAIQWGLKNATIEKEGAIFVDDNGELKLGGQALLILALSKYQDVTKDDTFMPVLMKAFKGVHFFQEPSGKLIHVLNPDLTVKAAYRIIYYEGEVAFALSRLYELTHDKNVMDLVKQILDYMVANDYGKYHDHWISYAINEALLVFPDNRDYMKLGLKNVFSHLKFIEERDTTYPTLLELVDAAVKMTDMIKRSGNEDLIAPYDLVRLRQVLRYRALYEITTGCFLPEIAMYLYNPQKFIGGFYARHDNFRTRIDDCEHFLSGLINYYNYTYRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA5</accession>
    <name>F9UNA5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1335"/>
    <dbReference type="EnsemblBacteria" id="CCC78694">
        <property type="protein sequence ID" value="CCC78694"/>
        <property type="gene ID" value="lp_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1335"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1126"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="KTTDITH"/>
    <dbReference type="PhylomeDB" id="F9UNA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1152-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="31623" checksum="DD08CA3E0282AB15" modified="2011-10-19" version="1">MTIKNAIEVINIAKSFQNTTALDQVSFTVQPGEIFGFLGPSGSGKTTTIKILTGQLLPTNGEAYVLGQSVQAYDEHRYEKIGIVTHQSGLYDKLSVYQNLLFFAKMFGVPVARVDKLLERVGLSQHKKKLAGKLSQGMRQRLVLARAILHQPQVLFLDEPTSGLDPRTTQTIHALIRELRDQGTAILLTTHDMLEATRLCNRVALLNAGRIAECAAPQALQLKYNRDQQYRVHIASAAQDLLLPASPETTYQINQWMLSGQLETIHSCEPTLEDVFLTVTGRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI0</accession>
    <name>F9UNI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha chain</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribB</name>
        <name evidence="4" type="ordered locus">lp_1436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1436"/>
    <dbReference type="EnsemblBacteria" id="CCC78769">
        <property type="protein sequence ID" value="CCC78769"/>
        <property type="gene ID" value="lp_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1436"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_1_9"/>
    <dbReference type="PhylomeDB" id="F9UNI0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1230-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15091" checksum="96CE9178A867299A" modified="2011-10-19" version="1">MVMPETVRRTNLKILVVGSLVNLERALQVNAHLDGHIVQGHIDYCGQVMQRQSDAHALRLLISLPSEYRALVVTKGSVAVDGVSLTVVAVTETTFEVDLIPHSQAVTTLSKLQVGTLVNVETDILGKYLARQLALEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI3</accession>
    <name>F9UNI3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1439"/>
    <dbReference type="DNASU" id="1062419"/>
    <dbReference type="EnsemblBacteria" id="CCC78772">
        <property type="protein sequence ID" value="CCC78772"/>
        <property type="gene ID" value="lp_1439"/>
    </dbReference>
    <dbReference type="GeneID" id="57025073"/>
    <dbReference type="GeneID" id="66449274"/>
    <dbReference type="KEGG" id="lpl:lp_1439"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1205"/>
    <dbReference type="eggNOG" id="COG3575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092842_1_0_9"/>
    <dbReference type="OMA" id="VWDKLHG"/>
    <dbReference type="PhylomeDB" id="F9UNI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1233-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009267">
        <property type="entry name" value="NTP_transf_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166">
        <property type="entry name" value="PTHR39166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06042">
        <property type="entry name" value="NTP_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="21556" checksum="357475317F03EF52" modified="2011-10-19" version="1">MTNEQRVIHIIKTTPALMTILQLIQDCHLKQGALAAGSIRNTVWQVLSGQPVMFNSDIDVVFFDPERPASDDLKIYQQLTDKAPQYQWQIKNEVYMAHYNFDKDPEFTSVTDAIGHFVEVPTCIGAFLDENQIKLIAPYGVDDLINFRCSPIPYYRQDAKHMAIYQQRMAQKQWHQQWPKLQIDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ8</accession>
    <name>F9UNJ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 3'-phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889301.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1457"/>
    <dbReference type="DNASU" id="1062379"/>
    <dbReference type="EnsemblBacteria" id="CCC78787">
        <property type="protein sequence ID" value="CCC78787"/>
        <property type="gene ID" value="lp_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="57025088"/>
    <dbReference type="GeneID" id="66449290"/>
    <dbReference type="KEGG" id="lpl:lp_1457"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1220"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093117_0_0_9"/>
    <dbReference type="OMA" id="DINHNNW"/>
    <dbReference type="PhylomeDB" id="F9UNJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1248-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="30764" checksum="D42D7BD6F79D5262" modified="2011-10-19" version="1">MDFELDDGWDVYPIYGNTNKAFMGKKNHQRLFLKRNASPFLAALSMEEITPRLIWTKRISSGDTLTAQEWLNGQTLTKQQMRLPEVAHLLARVHNSELLHRMLRKVGGQSVRPQDFIQQYLQDLPDDLRHHPLMARVLDELRGTAPTLPATDYRVCHGDLNHKNWLLSDRQQLYLVDWDSARFADPASDISMLLCEYVPLSDWQQWLSEYGETMTTALRTRVVWYAKINLLLNIKDNYYRNQYHQMNHEIIFLEELSQYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889319.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1477"/>
    <dbReference type="EnsemblBacteria" id="CCC78805">
        <property type="protein sequence ID" value="CCC78805"/>
        <property type="gene ID" value="lp_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1477"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1239"/>
    <dbReference type="eggNOG" id="COG0716">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_4_2_9"/>
    <dbReference type="OMA" id="AEDYCKA"/>
    <dbReference type="PhylomeDB" id="F9UNL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1266-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="16712" checksum="D9B01F2150B7BD6A" modified="2011-10-19" version="1">MKAEIIYASLTGNNEEIAEIIQNQLREHHVDTNFTEIGQADAFDLPVADLIVIVPYTYGEGDLPEEGLDFFDDLQDVNLSGTVFGVAGSGDRWYAEDYCKAVVEFDHQLETTGATQGVQPLFIDLHPEDADEQRLDDFTTSLIKTATQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP80</accession>
    <name>F9UP80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-aminobutanoate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101523.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1722"/>
    <dbReference type="EnsemblBacteria" id="CCC79019">
        <property type="protein sequence ID" value="CCC79019"/>
        <property type="gene ID" value="lp_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1722"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1454"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_9"/>
    <dbReference type="OMA" id="WQLTMIS"/>
    <dbReference type="PhylomeDB" id="F9UP80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1482-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
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            <end position="293"/>
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    </feature>
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            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="499" mass="53152" checksum="056FA6ACD09CDAE0" modified="2011-10-19" version="1">MQRLLKRLTLKEDPSIYEDKDSHLARVLTVKDFLALGVGTIVSTSIFTLPGVVAANHAGPAVVFSFIVAAVVAGLVAFAYAEMAAAMPFAGSAYSWINVMFGEFFGWIAGWALLAEYFIALAFVGSGLSANLRGLLSPLGLTLPKALSNTFGTDGGVVDLIAVLVIALVSLLLSRGISKASRVENVLVVLKVLAVLTFIVVGATAIHVQNYVPFIPKYHLNADGSAFGGWQGIYAGVSMIFLAYIGFDSIAANSAEAKNPGKTMPRGILGSLVIAVVLFVAVALVLVGMFKYSSYANNAEPVGWALRQAGHPIVASVIQAIAVLGMFTALIGMTLAGSRLIYSFGRDGMLPKWLGKLHRNQPNNALLVLTIVAIIIGAFCPFAFLAQLISAGTLIAFMFVSLGIYALRRREGVDIAVPAFKMPFYPVLPAIAFLGALFVFMGLDIQAKLYAGVWFIVGLVIYFSYGMRHSYLAEKRLSETDTAAKSASKVADSTVEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP90</accession>
    <name>F9UP90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mevalonate kinase</fullName>
            <ecNumber evidence="8">2.7.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mvaK1</name>
        <name evidence="8" type="ordered locus">lp_1735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889543.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1735"/>
    <dbReference type="EnsemblBacteria" id="CCC79029">
        <property type="protein sequence ID" value="CCC79029"/>
        <property type="gene ID" value="lp_1735"/>
    </dbReference>
    <dbReference type="GeneID" id="57025358"/>
    <dbReference type="KEGG" id="lpl:lp_1735"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1464"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_9"/>
    <dbReference type="OMA" id="HSAVYGF"/>
    <dbReference type="PhylomeDB" id="F9UP90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1492-MON"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="32930" checksum="191E4CEAB97FF3D6" modified="2011-10-19" version="1">MKDLATGTSHAKIILIGEHGVVYGQPAIALPISTIQMQAIIHRRDAAQTVKSRYFNGDFKMMSANLGGIQTLIRTLLARFDAPEQGFDIHITSDIPSERGMGSSAAAAVAVTRAFYDFFDRPLSHQELLATANVAESYTHGQPSGLDVATASAKSPVWFVKGRENFPIPVKLPGYLVIADTGIKSQTKVAVATVRNLLMVEGATIQARIDDLGRLTRQTRTALEDGDMGALATALNGAQDDLRSMGVSHPALEQLLAVARQNGALAAKLTGSGQGGCLIALAPEASIANQLSQKLAAAGATATWVEPLLCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP99</accession>
    <name>F9UP99_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-methionine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889552.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1745"/>
    <dbReference type="EnsemblBacteria" id="CCC79038">
        <property type="protein sequence ID" value="CCC79038"/>
        <property type="gene ID" value="lp_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1745"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1471"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_9"/>
    <dbReference type="OMA" id="TFWSAIF"/>
    <dbReference type="PhylomeDB" id="F9UP99"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1501-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="223" mass="23636" checksum="F42794CE5E9C5AFC" modified="2011-10-19" version="1">MTALIPNVLQMKAEFIQATLETLYMTAVSALVAGILGLGLGVLLVVTQPHGILADGPSYQVLDKLTNLLRSVPFIILLAVISPLTSYLIGTTVGTTASLVPLVFGIFPFYARQVQNALLDVDQGIVEAAQSMGSSPIAIIFRVYLKEGLPDLIRVSIVTVISLIGLTTMAGAIGAGGLGDIAISIGYARFENDVTFVAMIIILILVFAIQLFGDWLVKSVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA1</accession>
    <name>F9UPA1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1747"/>
    <dbReference type="EnsemblBacteria" id="CCC79040">
        <property type="protein sequence ID" value="CCC79040"/>
        <property type="gene ID" value="lp_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1747"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1473"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="VSHKVSQ"/>
    <dbReference type="PhylomeDB" id="F9UPA1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1503-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18115" checksum="DE74A59E21377C43" modified="2011-10-19" version="1">MYKRILVPLDGSDNAYYALEHAIALAKVFDSQLFLLNVIDVNRFGVYSPDVFTSAAPDMMSFDQAQSKKLLERAQDQVAAHQLHAETIRQTGVPKVTIAVDVPKAQNIDLIVIGRSGTNAISRLFLGSTTAYVVRNTEANVTVVNMPSDEAEEVEQTGDVSADDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB5</accession>
    <name>F9UPB5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muramoyl-tetrapeptide carboxypeptidase, S66 family</fullName>
            <ecNumber evidence="6">3.4.17.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.13" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889568.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1764"/>
    <dbReference type="EnsemblBacteria" id="CCC79054">
        <property type="protein sequence ID" value="CCC79054"/>
        <property type="gene ID" value="lp_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1764"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1488"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_0_9"/>
    <dbReference type="OMA" id="VEYPTTR"/>
    <dbReference type="PhylomeDB" id="F9UPB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1518-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106415">
        <property type="term" value="F:muramoyltetrapeptide carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="213"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="359" mass="41030" checksum="225828D31A6FAEB4" modified="2011-10-19" version="1">MLKPAPLHVGDHVAVVSLSSGTLGELTQQHQLNRGLKRMRQLGLVPVMMPNALKGRLILQQRPELRAADLKTAFLDPSIRGVVAAIGGDDTYRTVPFLMADEQFKTAVRRSPKLFTGFSDTTINHLMFYQLGLQTFYGPNFLSDLAELGPTMLPYTTKTWQRYFENPQQTSIISSPVWYDERTNFSESAQETRRMTHTEMHHYEVLRGHGTISGTLLGGCLDSFYDLLTTTRYPDERQVAEQFRLIPCAAEWRGKILFIETSDEQPQPDLFKRMLQRMRQAEILTNVAAVIVGKPQNEHYYQEYRQILIDETADLKLPILYNINFGHAFPRTALPYGAQVCIDFEQATLKILEPWFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC6</accession>
    <name>F9UPC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889579.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1778"/>
    <dbReference type="EnsemblBacteria" id="CCC79065">
        <property type="protein sequence ID" value="CCC79065"/>
        <property type="gene ID" value="lp_1778"/>
    </dbReference>
    <dbReference type="GeneID" id="57025391"/>
    <dbReference type="KEGG" id="lpl:lp_1778"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1499"/>
    <dbReference type="eggNOG" id="ENOG502ZPAS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135677_2_0_9"/>
    <dbReference type="OMA" id="ITHFQWI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1528-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020215">
        <property type="entry name" value="EbsA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17255">
        <property type="entry name" value="EbsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14863" checksum="EE33CA282A31F09B" modified="2011-10-19" version="1">MNNDKHTFKYQPMLASSVIVWSWTALVLMAGIILWLEILKFKWWLLVIAALFIALVAIQISLRRVTINHNLIIFSTVLNHSWLVIPRDQLELIVPIRGGLKVQIDGNQYRFLMLKKARNQLIDLATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD8</accession>
    <name>F9UPD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1790"/>
    <dbReference type="EnsemblBacteria" id="CCC79077">
        <property type="protein sequence ID" value="CCC79077"/>
        <property type="gene ID" value="lp_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1790"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1511"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_1_9"/>
    <dbReference type="OMA" id="HHIMAFY"/>
    <dbReference type="PhylomeDB" id="F9UPD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1540-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="18352" checksum="6162AEB065EE66E5" modified="2011-10-19" version="1">MAIYHRAFGVYGIIGDEHALVVTKKFGGPYTNRYDLPGGSLADGEPLLAAIRREIQEETGLIPTELTQLGITNFRYPWQFKQWRMNQHLAVFYRVTRTTGQLAEHVANFDGQDSHGASRVPLHALTEANASPLVLKAKAVLLSGQFDPSDQTYPDWTVLDHPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPM3</accession>
    <name>F9UPM3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pyk</name>
        <name evidence="20" type="ordered locus">lp_1897</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889676.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1897"/>
    <dbReference type="EnsemblBacteria" id="CCC79162">
        <property type="protein sequence ID" value="CCC79162"/>
        <property type="gene ID" value="lp_1897"/>
    </dbReference>
    <dbReference type="GeneID" id="57025488"/>
    <dbReference type="KEGG" id="lpl:lp_1897"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1598"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_9"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="PhylomeDB" id="F9UPM3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1624-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="17">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="19">
        <location>
            <begin position="358"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="507"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCC79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="586" mass="62867" checksum="21D8F52F84E274FC" modified="2011-10-19" version="1">MKKTKIVSTLGPASTDTDTIVKLIEAGANIFRFNFSHGDHEEHLDRLNKVHEAEKITGKTVGIMLDTKGAEIRTTVQANGKSEYKIGDKVRITMDDSLDTTHDKIAVTYKNLYDDVHVGGHVLFDDGLLDMKIDEKDEANRELVTTVQNAGVLGSRKGVNAPGVSINLPGITEKDSSDIRFGLDHEINYIAASFVRKPQDVLDIRELLEEKHMEHVQIFPKIESQEGIDNADEILKVCDGLMVARGDMGVEIPAENVPLVQKSLIKKCNALGMPVITATQMLDSMQENPRPTRAEASDVANAVFDGTDATMLSGESANGLYPVESVAMMAKIDEKAENTLAENGTLQLNRFDKTSVTETIGIAIARAAKNLNIKTIVAATESGYTAKMISKYRPNADILAITFDERTQRGLMVNWGVQPIVAEKPETTDDMFDLAASKAVELGFAKEGDLILITAGVPVGERGTTNIMKIQLIGSKLADGQGVGDETVIGKAVIATSAQEAIDKAVEGGVLVTKTTDKDYLPAIEKSSALVVENGGLTSHAAVVGISMGIPVIVGVKDATSVIADGQLITVDSRRGLVYRGASNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPM8</accession>
    <name>F9UPM8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase T</fullName>
            <ecNumber evidence="7">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aminotripeptidase</fullName>
            <shortName evidence="7">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pepT</name>
        <name evidence="11" type="ordered locus">lp_1904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889681.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1904"/>
    <dbReference type="EnsemblBacteria" id="CCC79167">
        <property type="protein sequence ID" value="CCC79167"/>
        <property type="gene ID" value="lp_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1904"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1604"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_9"/>
    <dbReference type="OMA" id="GHNFHGK"/>
    <dbReference type="PhylomeDB" id="F9UPM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1629-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="412" mass="45162" checksum="F1CE3B0B59EA4FA4" modified="2011-10-19" version="1">MSKYPNLISDFLTFVKINSRSDEESTTIPSSPRETAFLKQLMSKLTDLGLSDVEQDAQSAYVFATIPANSDKAVKTLGFISHIDTADFNAENVNPQIVDNYDGESVIKLGNGDYVLDPAVFPNLKNYAGHTLITTDGTTLLGADDKSGVAEIISAAEYLLAHPEIKHGKIRLAFGPDEEIGTGADHFNVPAFGADYAYTVDGGPLGELEYETFNAAQATVTITGVNVHPGEAKDKMVNALQLAVDFQSALPAHDVPEHTEGREGFFFLLSLDGTVDSAKMTYIIRDHDRDKFEARKRLFMAVADRLNLADGVARIKVDMKDQYYNMREIIEKDMRVVELAKQAMLKLGITPAIYPVRGGTDGSKISFMGLPTPNLFAGGENMHGRFEYVSEQVMAQAVDVVLQIVQDNYDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN6</accession>
    <name>F9UPN6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-12" db="PDB data bank">
            <title>Crystal structure of lp_1913 protein from Lactobacillus plantarum,Northeast Structural Genomics Consortium Target LpR140B.</title>
            <authorList>
                <person name="Seetharaman J."/>
                <person name="Chen Y."/>
                <person name="Forouhar F."/>
                <person name="Sahdev S."/>
                <person name="Foote E.L."/>
                <person name="Ciccosanti C."/>
                <person name="Belote R.L."/>
                <person name="Everett J.K."/>
                <person name="Nair R."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-116</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2008-12" db="PDB data bank">
            <title>Crystal structure of the full-length lp_1913 protein from Lactobacillus plantarum, Northeast Structural Genomics Consortium Target LpR140.</title>
            <authorList>
                <person name="Seetharaman J."/>
                <person name="Chen Y."/>
                <person name="Forouhar F."/>
                <person name="Sahdev S."/>
                <person name="Janjua H."/>
                <person name="Xiao R."/>
                <person name="Ciccosanti C."/>
                <person name="Foote E.L."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2009-06" db="PDB data bank">
            <title>Crystal structure of lp_1913 protein from lactobacillus plantarum, northeast structural genomics Consortium target lpr140a.</title>
            <authorList>
                <person name="Seetharaman J."/>
                <person name="Chen Y."/>
                <person name="Forouhar F."/>
                <person name="Sahdev S."/>
                <person name="Janjua H."/>
                <person name="Xiao R."/>
                <person name="Ciccosanti C."/>
                <person name="Foote E.L."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 1-112</scope>
    </reference>
    <reference key="5">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="6">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640617.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889689.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3FLH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C=1-116"/>
    </dbReference>
    <dbReference type="PDB" id="3FNJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-122"/>
    </dbReference>
    <dbReference type="PDB" id="3I3U">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-112"/>
    </dbReference>
    <dbReference type="PDBsum" id="3FLH"/>
    <dbReference type="PDBsum" id="3FNJ"/>
    <dbReference type="PDBsum" id="3I3U"/>
    <dbReference type="SMR" id="F9UPN6"/>
    <dbReference type="STRING" id="220668.lp_1913"/>
    <dbReference type="DNASU" id="1064179"/>
    <dbReference type="EnsemblBacteria" id="CCC79175">
        <property type="protein sequence ID" value="CCC79175"/>
        <property type="gene ID" value="lp_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1913"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1612"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046713_0_0_9"/>
    <dbReference type="OMA" id="YVVYDWT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1637-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3FLH"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3FNJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3I3U"/>
        </source>
    </evidence>
    <sequence length="122" mass="13268" checksum="5701CA3F4D71E360" modified="2011-10-19" version="1">MNDKKIELLTTYLSLYIDHHTVLADMQNATGKYVVLDVRNAPAQVKKDQIKGAIAMPAKDLATRIGELDPAKTYVVYDWTGGTTLGKTALLVLLSAGFEAYELAGALEGWKGMQLPVETLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR1</accession>
    <name>F9UPR1_LACPL</name>
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        <submittedName>
            <fullName evidence="5">NADH oxidase</fullName>
            <ecNumber evidence="5">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nox4</name>
        <name evidence="5" type="ordered locus">lp_1941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.99.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101602.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889714.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1941"/>
    <dbReference type="EnsemblBacteria" id="CCC79200">
        <property type="protein sequence ID" value="CCC79200"/>
        <property type="gene ID" value="lp_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1941"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1638"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_9"/>
    <dbReference type="OMA" id="YERRTHQ"/>
    <dbReference type="PhylomeDB" id="F9UPR1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1663-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="331"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="468" mass="51994" checksum="51270D31E2FF3D8B" modified="2011-10-19" version="1">MKVMIIGSTHAGTAAAREILTRHPETAVTIYERNDNVSFVSSGIYLYLTGVIQHLEDMFYTSPSDLKQLGAQVKTRHNVLRIDTGHKTVQVANMQTGEVFDDTYDKLIMATGSSVIVPPIMGIDHEKVLLCKNYEQAEQLYQSLQANQRVAIVGAGYMGTELAESYASMDQQVMLFHSHSHILNNYLGPQMADAATKLLQHHQVDIHLNERVTGFASGSNDQLIVETAQGDYEVDLAVVCAGFMPNTELLRGQVAMDRHGAILINDYVQTSDPDIYAAGDACVVNYNPTGQPAYTPLATNALRQGALAGINVFGDLQPYMGTQATSAMQLFDHTMATTGLTYLAAQRRELPVRHAVYQGNWRPAYMPTTAKVTIELVYNYQNRQLLGAQFWSRHDIAQAANTISVMIQNQNTIDDLAYVDMFFQPNFNQPFNYLNLVGQLAVKQEYQRGNQTPRITARGNWSTSSDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV9</accession>
    <name>F9UPV9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101618.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79248">
        <property type="protein sequence ID" value="CCC79248"/>
        <property type="gene ID" value="lp_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2000"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1689"/>
    <dbReference type="HOGENOM" id="CLU_1029706_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1712-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394288" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="270" mass="30181" checksum="AD4B976ABC87136F" modified="2011-10-19" version="1">MLNIFSLIISIISLISSIIIAIRQNKQTNNSTKIANQGNNLTNAGNNIANYSANVQIKELAPILFNTSQDFQTAPASTASNAYSTTLKVTGYLTTTFGSISWIGTLVPNYFPAYSFDATNISQSASTNKNNSYFDTTFTITRTETVDNFIRSRVYICTLDSNFNISINLIQLIVERLSESSIREVIVDSSPDGPYHFKAVDGFYRCFTEYELLTYKTLRLIKPWIDSKSSGSMSLKSQEKISTIFEDNEPFNLIQNELKEIRSHITSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ25</accession>
    <name>F9UQ25_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645636.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2074"/>
    <dbReference type="EnsemblBacteria" id="CCC79314">
        <property type="protein sequence ID" value="CCC79314"/>
        <property type="gene ID" value="lp_2074"/>
    </dbReference>
    <dbReference type="GeneID" id="57025620"/>
    <dbReference type="KEGG" id="lpl:lp_2074"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1756"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_17_4_9"/>
    <dbReference type="OMA" id="WIRYISE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1774-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="22666" checksum="D66DC5D6718B8F03" modified="2011-10-19" version="1">MVTEKLAIILGLEKTNLTKSTCFKACGIARSTFIRCQNFYMQDGLEGLKEQHNWIRYISEIKRQAISAYLNDESSLWDIQIRFGLRSTRRLEDRISELLVHIMSRKITFEERIRIVEYITVSEHAYSRAAKHYNVSYQQIRFWMLKTTTNGYIALKDRLGWTKPIEKMTEVERLRLKKRQLKIQIKEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ85</accession>
    <name>F9UQ85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein, cell-wall anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101668.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889888.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79374">
        <property type="protein sequence ID" value="CCC79374"/>
        <property type="gene ID" value="lp_2145"/>
    </dbReference>
    <dbReference type="GeneID" id="57025680"/>
    <dbReference type="KEGG" id="lpl:lp_2145"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1815"/>
    <dbReference type="eggNOG" id="ENOG50325XR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688476_0_0_9"/>
    <dbReference type="OMA" id="WSKEMPI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1835-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026409">
        <property type="entry name" value="Firmicu_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04145">
        <property type="entry name" value="Firmicu_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394289" evidence="3">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="433" mass="45794" checksum="003BF024F852BD84" modified="2011-10-19" version="1">MKKINKLMILGMLVFGVTGATMINPEMTTAAHASANITIDGKMNDWKDATLTEGYNGYTALASAGQYVNVYVKMKNGAVPGYGDYNFTIDGKTYYIWSKNISGSVSSGTVKSFTLTGGKWNDGTQYGTVGTGYVTNDGSHNYAEFQIDLTKLGLTDSASGKQISMVNPNIGSDSTTSTVGTITATSTSSSSSTSSSTNANSTTSSSSTTSTSSAASSSATSSAGVITDKSTVSSKASSTTDNNAANDNDNLNIKIDGNFNDWKNVTLTEGYNGYMAMVSDGKYVYVYVKMKYGQVPGYGDYNFDIGGQKYYVWSNEMPSSQSDGAVKAVSFTGGKYNEGHQYGTVGNGYVSQAGSHSIAEFRVDLSKFDISTMTGQTITMSNPNIGNQKMTVAGGSTGPYVISGVGVVIVAWGYFKFRKRRRLTATDLPTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE8</accession>
    <name>F9UQE8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dithiol-disulfide isomerase, DsbA family,FrnE-like subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101687.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889951.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2224"/>
    <dbReference type="EnsemblBacteria" id="CCC79437">
        <property type="protein sequence ID" value="CCC79437"/>
        <property type="gene ID" value="lp_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2224"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1879"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093802_2_0_9"/>
    <dbReference type="OMA" id="NLANYHN"/>
    <dbReference type="PhylomeDB" id="F9UQE8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1898-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="23946" checksum="8F5D0FF1D3F7AF17" modified="2011-10-19" version="1">MLEVYLFVNPLANQCVRDEQNVLRLANDSDKQIQFQFVPLLNINVIQRALKCQGIKASDWHAQNQQSQTLYRVILDYKAALFQGKKRGRNFLIALQSAMLKTGQHYSEELVKTVATNCQIDLDMFMEDRDSDLAKQAFHADQRLASEMNITEASSAVVFDCDQYDYGVLLEHFNYTTLFDLVNGNLDPFQDATRATNASCASLANAQLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM4</accession>
    <name>F9UQM4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell shape determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ordered locus">lp_2317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2317"/>
    <dbReference type="EnsemblBacteria" id="CCC79513">
        <property type="protein sequence ID" value="CCC79513"/>
        <property type="gene ID" value="lp_2317"/>
    </dbReference>
    <dbReference type="GeneID" id="57025849"/>
    <dbReference type="KEGG" id="lpl:lp_2317"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1958"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121959_0_1_9"/>
    <dbReference type="OMA" id="VCVLEFY"/>
    <dbReference type="PhylomeDB" id="F9UQM4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1997-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="19769" checksum="DF3DA6A64185D790" modified="2011-10-19" version="1">MRYSRLKIIFPIGLFVALFLDGSVSNVFAGKLFSYPYASVLHLVLLWIVFAVFLDDRDNLSVGIWSAFVGLVFDWYYTGILGVYMIGLPLVVYICRQIKPWIDLNFLTLLMIYIINLTILEAFTYIWYTMSHVISSGLADFAVYTLGPTIAVNLAIFVILYYPMRRLYLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQN0</accession>
    <name>F9UQN0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol peroxidase</fullName>
            <ecNumber evidence="4">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tpx</name>
        <name evidence="4" type="ordered locus">lp_2323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644643.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UQN0"/>
    <dbReference type="STRING" id="220668.lp_2323"/>
    <dbReference type="EnsemblBacteria" id="CCC79519">
        <property type="protein sequence ID" value="CCC79519"/>
        <property type="gene ID" value="lp_2323"/>
    </dbReference>
    <dbReference type="GeneID" id="57025855"/>
    <dbReference type="KEGG" id="lpl:lp_2323"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1964"/>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_12_0_9"/>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="PhylomeDB" id="F9UQN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2003-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="18191" checksum="A0E4EE10C5CF3EB8" modified="2011-10-19" version="1">MQVLFHDQALDLVGEPLQDGDQLPKFKVFTTHDEKIKTKDLLGKPVLLSVMPDIDTRVCSIQTKKFNQQADKYPHVQFLAISNNAVADQAGWCAKEGVKNLTVASDEELSFGYATNLYLPNNGTLTRAIYVADAAGKIVYHEIVPDVSHEPNYVAALDALKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP9</accession>
    <name>F9UQP9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641457.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890052.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2346"/>
    <dbReference type="EnsemblBacteria" id="CCC79538">
        <property type="protein sequence ID" value="CCC79538"/>
        <property type="gene ID" value="lp_2346"/>
    </dbReference>
    <dbReference type="GeneID" id="57025882"/>
    <dbReference type="KEGG" id="lpl:lp_2346"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1983"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_0_9"/>
    <dbReference type="OMA" id="QTEDMIA"/>
    <dbReference type="PhylomeDB" id="F9UQP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2022-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="36096" checksum="A524B653FFCC3E8C" modified="2011-10-19" version="1">MQAKAVGLTQGLPVSDPNSLQDVTINVNQPRGRDILVAVLATAVNPIDTKQRQGQSPVTTPRILGFDAVAKVLAVGEAVTTIMTDDVVYYAGAVDRPGSDAQYQLVDERLVACAPKTWSPAQSAGLPLTTLTAWEALFEKLPFTAAADANLGQSVLIINGAGGVGSMAIQLAKWAGLQVITTTGKPETTEWVKRLGADIVLDYHQDLGSQLAAAGLQAVDHAILLHSTDQYLPLVTPLVRPLGTIVAVVTNQHPLPMALLKPKSLNFAWEFMFTKANYQLPSMATQGSILAQVAQLADAGVIVPTTKRTLAGINAANLRTAHTIVETGQMLGKIVLTAPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ1</accession>
    <name>F9UQQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-2-hydroxyisocaproate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hicD3</name>
        <name evidence="7" type="ordered locus">lp_2349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="220668.lp_2402"/>
    <dbReference type="EnsemblBacteria" id="CCC79581">
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            <dbReference type="EMBL" id="CCC79581.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="39" mass="4177" checksum="273C6E59B139C5FA" modified="2011-10-19" version="1">MNKHKLKALILTVGAIFMAFLMVNVTSQASATVDNNGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQV7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="352" mass="38088" checksum="CEEC3F694932FF26" modified="2011-10-19" version="1">MVNGNITQLSDMKIPEHWGAYLAEKSTQNNAFFTSGVVQSVPQIAALLGAGKVANMPLFKPLADNDPQVPDDTTDLLVNKITTDLAQARKLGFDQAWSATDLSAELSGADPLSAIGDQVSDYWSHIYEKLLLKTLTGVFSSASMKGVNQLDATADKTDTTFSLKNFNKARFLLGDRYKDLAIVAVHSDVLRQLQDANLVDAKNNSTFVLNGNSNVPTSIQAPDAGDKIKGVQIVVDDSLPVSGGKYTSYLFAQGAVGYSELPVINAVETNRDPLKNHGVDYLVNRRRFVFAPQGLSWNESNFTSKHSGKAYPTMDDLADGTNWTKVYDQKLIPMAQFVTSADPIVPGSGLGH</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </source>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    </reference>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        </subcellularLocation>
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    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101814.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890207.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2531"/>
    <dbReference type="EnsemblBacteria" id="CCC79693">
        <property type="protein sequence ID" value="CCC79693"/>
        <property type="gene ID" value="lp_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2531"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2129"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_1_3_9"/>
    <dbReference type="OMA" id="ETDATIM"/>
    <dbReference type="PhylomeDB" id="F9UR54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2186-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dup_hybrid_motif"/>
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        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
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        <property type="entry name" value="PTrfase_EIIB_Cys"/>
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        <property type="entry name" value="PTS_EIIA_1_perm"/>
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        <property type="entry name" value="PTS_EIIC"/>
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        <property type="entry name" value="PTS_EIIC_1"/>
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        <property type="entry name" value="PTS_IIB_1"/>
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        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTBA"/>
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        <property type="entry name" value="PTS-II-BC-nag"/>
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    </dbReference>
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        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
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        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="259"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="287"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="312"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="369"/>
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    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="407"/>
            <end position="489"/>
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    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="533"/>
            <end position="637"/>
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    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="429"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="662" mass="70323" checksum="ADAD7EDC4905B22D" modified="2011-10-19" version="1">MKTYFQKIGQSLMLPIATLPAAAILVGIGNYLPKQWLFANYLIQGGNVVLNNLALLFAVGLAIGMSVNKDGAAAIAGLIAFEVPVMVLKPATLATMLNVKVSQINPAFSALDNNVLIGISAGLIAAALYNRFHEVKLPMALSFFSGKRLVPIMAAFVMLIVTAVLYLVWPFVYDAIVLFATGISKLGFVGAGLYGFFNRLLIPTGLHHALNSVFWYNVAGINDIGNFWASHGVKGITGMYEAGFFPIMMFGLPAGAYAIYRNARPERKKEVGSLMLAGAFASFFTGVTEPLEFSFMFVAWPLYLLHAVFMGLSLGFAALMHWTASFSFSGGLVDYLLSFRMPLANQPYMLLVQGLVMAVIYYFGFDFAIKRFNLKTPGREVVSADVDGVGAPASPAVAVAATDDKYMRQAKQIYAAIGGHDNISVINNCTTRLRLQLKDTEKVDQPAVMAAGVPGLNVLDVHNIHIVIGTEVQFVAEALQKLFSGQVATTPASDAESKAPVEPQTATVTEAPVTTILRAPATGQLMPISTVADETFAGKLLGDGYAVEPEDGEVVAPVSGTVTSVFPTKHAIGLKTTSGLEVLLHMGINTVEMNGTPFKLHVATGDEIAAGTAVATVDLAAIKSAGKATTMMVVITNMDHVNKLTLNPTGHVTSGDLIGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD2</accession>
    <name>F9URD2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine gamma synthase/O-succinylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="4">2.5.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cgs</name>
        <name evidence="4" type="ordered locus">lp_2634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101860.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890285.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2634"/>
    <dbReference type="EnsemblBacteria" id="CCC79771">
        <property type="protein sequence ID" value="CCC79771"/>
        <property type="gene ID" value="lp_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2634"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2209"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_9"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="PhylomeDB" id="F9URD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2262-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102028">
        <property type="term" value="F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="40513" checksum="862224503867F60F" modified="2011-10-19" version="1">MTKQAEKLHIETRLAQAGNRSDDEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYSGRGGMISFYLATGTDVDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF2</accession>
    <name>F9URF2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2662"/>
    <dbReference type="EnsemblBacteria" id="CCC79791">
        <property type="protein sequence ID" value="CCC79791"/>
        <property type="gene ID" value="lp_2662"/>
    </dbReference>
    <dbReference type="GeneID" id="57026052"/>
    <dbReference type="KEGG" id="lpl:lp_2662"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2230"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_3_2_9"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="PhylomeDB" id="F9URF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2282-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="167" mass="18591" checksum="490CDC9771E17810" modified="2011-10-19" version="1">MSKKKKKDQLGKTLVEKILDKANISYQQYEFPTEAEGDVQQLQVDHLGVDEHHIYKTLALIGNKTGPVVGVLPLDEHLSYKKLAKLSGNKKVGMIPLKDLERTTGYQHGANTPVGIWETKKFPIYLDETAKQQGKILVSSGKIGRSIEIDADDLRKLVHGTFGPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH4</accession>
    <name>F9URH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase, atypical SDR family,subgroup 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2690"/>
    <dbReference type="EnsemblBacteria" id="CCC79813">
        <property type="protein sequence ID" value="CCC79813"/>
        <property type="gene ID" value="lp_2690"/>
    </dbReference>
    <dbReference type="GeneID" id="57026073"/>
    <dbReference type="GeneID" id="66450350"/>
    <dbReference type="KEGG" id="lpl:lp_2690"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2252"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_2_9"/>
    <dbReference type="PhylomeDB" id="F9URH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2304-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="22893" checksum="24C7B6A85130149B" modified="2011-10-19" version="1">MKIFVIGAHGQIGKKIVSKLVAQGDQVYAGIRQPEQAEAFEDAGAQPVQFNLMAQPEDLALAFNGMDAIVFAAGSGGQTGYDMTLMIDLDGAVKSMVAAKIAGVKRYVIISAEFTPDRSRWPRALQPYYVAKYYADEWLKNRTQLDYTILQPGTLINDAGTGKVTVNPDVGGEITRDDVATFTVQTLHTPATVGKTIALINGDTPISKAVQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL5</accession>
    <name>F9URL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642575.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890368.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2741"/>
    <dbReference type="EnsemblBacteria" id="CCC79854">
        <property type="protein sequence ID" value="CCC79854"/>
        <property type="gene ID" value="lp_2741"/>
    </dbReference>
    <dbReference type="GeneID" id="57026114"/>
    <dbReference type="KEGG" id="lpl:lp_2741"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2294"/>
    <dbReference type="eggNOG" id="ENOG5030A5N">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2423266_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2345-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="91" mass="10438" checksum="60B58971B3438F8D" modified="2011-10-19" version="1">MVYFGLVALLIVITPLHRYVLASRRQFWLGALMPLLWLSVNFGLATQIIFEHQDILLAVLGTLLLLSSWIAARIDRTERQLHQPQQKATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP2</accession>
    <name>F9URP2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642548.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890395.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2772"/>
    <dbReference type="EnsemblBacteria" id="CCC79881">
        <property type="protein sequence ID" value="CCC79881"/>
        <property type="gene ID" value="lp_2772"/>
    </dbReference>
    <dbReference type="GeneID" id="57026142"/>
    <dbReference type="KEGG" id="lpl:lp_2772"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2321"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_3_9"/>
    <dbReference type="OMA" id="RICVGPL"/>
    <dbReference type="PhylomeDB" id="F9URP2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2372-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="223" mass="25262" checksum="E01763E4EA08F4B4" modified="2011-10-19" version="1">MERPRIRDYFQHDLSQNETITPKQRAILQASLDLFAEKGFDQTSTSDIAQRAGVAEGTVYRRYKTKAALRDAILAPIAAHIVPILASDFSEDELRQRYPSLQAFVTAIFTDRVAFAKANVKELKVIFEMAAFDAERREQILSQIAPKMVKQMGSVINQLKADHLIVDWPNDLILQSLLSQLFGYLARLMLELPGTEIEREQAYLITVMTKILTPGEHDQITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP4</accession>
    <name>F9URP4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890397.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2774"/>
    <dbReference type="EnsemblBacteria" id="CCC79883">
        <property type="protein sequence ID" value="CCC79883"/>
        <property type="gene ID" value="lp_2774"/>
    </dbReference>
    <dbReference type="GeneID" id="57026144"/>
    <dbReference type="KEGG" id="lpl:lp_2774"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2323"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="PhylomeDB" id="F9URP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2374-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="27060" checksum="B04B60A442F7E8A9" modified="2011-10-19" version="1">MATDYVIAKQVSKHFGHQQVLNQIDLTLPAGMIYGLIGPSGAGKTTLIKSILGMEAVDSGTVKVMDTVMPNRAVMAQVGYMAQSDALYETLTARENLTFFGQLMSVPKIKLAQMIDYAAGLVDLTSQLDKRVSGYSGGMKRRLSLAIALIQDPQLLILDEPTVGIDPELRQQIWTELNKLKDTGKSMLVTTHVMDEAERCDYLMLIRHGIALAEGTPAALKQQYAVDTIEQVFLKAGRMQDANDGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ8</accession>
    <name>F9URQ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-09" db="PDB data bank">
            <title>Crystal structure of putative dinucleotide-binding oxidoreductase (NP_786167.1) from Lactobacillus plantarum at 1.60 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NADP</scope>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Boekhorst J."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
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                <person name="Nierop Groot M.N."/>
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                <person name="Ursing B."/>
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                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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                <person name="van Hijum S.A.F.T."/>
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                <person name="Francke C."/>
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                <person name="Boekhorst J."/>
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</entry>
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                <person name="Boekhorst J."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
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    </reference>
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    <dbReference type="KEGG" id="lpl:lp_2963"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2472"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_0_4_9"/>
    <dbReference type="OMA" id="NAYPTYL"/>
    <dbReference type="PhylomeDB" id="F9US97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2523-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_8" evidence="2">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23144" checksum="F1B089DFD1AEA319" modified="2011-10-19" version="1">MMTTNYPLAVQKMFATVPTLLTATPIFKLTVTMVVKAAHVSRGSFYSHFQDIYDFIHAFEHALIEQATVSKQVLNQGIQAALVHPDPHNAYPTYLELTTNINTQLASFQALLGPHGDPQFLDQLQAGLIDNLLATTEQAPLNHQYFQSIPADYAMPIYFSGVLTIIQHWLTKPHPEPPEVVANIIVQSRYTAAYHLFSDRPLGDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB5</accession>
    <name>F9USB5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter,permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livC</name>
        <name evidence="7" type="ordered locus">lp_2983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101995.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890559.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2983"/>
    <dbReference type="EnsemblBacteria" id="CCC80045">
        <property type="protein sequence ID" value="CCC80045"/>
        <property type="gene ID" value="lp_2983"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2983"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2490"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_9"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="PhylomeDB" id="F9USB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2540-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="33820" checksum="62E5D7CBEEA07AC0" modified="2011-10-19" version="1">MKANLKTNMAWLGVMVIGFVVIDGLELMGVINSFIENMLVTIGINVILAVGLNLIIGFAGQFSLGHVGFMAIGAYATGIMTQTMATPAGFYLSMIVGMVIAMVAAVIVGIPTLRLRGDYLAIATMGAAEIIRILINNLKITNGAAGLFNIPALASWATVYVLMCLTTIITVNFIHSRGGRAVMAVRDDELAAGAMGINTTRWKLAAFVFGAATAAIGGSLHAAYIQTIAPGDFNIMASIAILIIVVLGGVGSITGTFVAAIVLGALDTILQNFGTIRMIIYSLALILIMIFKPAGLLGTWEFSFTRLFRRRSTKEAVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD1</accession>
    <name>F9USD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890575.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3002"/>
    <dbReference type="EnsemblBacteria" id="CCC80061">
        <property type="protein sequence ID" value="CCC80061"/>
        <property type="gene ID" value="lp_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3002"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2506"/>
    <dbReference type="eggNOG" id="ENOG50309XC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046664_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2555-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="14075" checksum="61AAC3A04EB296C1" modified="2011-10-19" version="1">MNFAPSEWFGFNKRARHDMTFTKTINGETSTKQVYGHFNVWALLFTWFYALFSVRCRTPFFLLKTAVSFLGMLSLNMVTQLFFSDQVVMSIGLLGDIWYGFMFETWFRNQLVANGYQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF7</accession>
    <name>F9USF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidyl-ethanolamine binding protein (PEBP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890601.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3030"/>
    <dbReference type="EnsemblBacteria" id="CCC80087">
        <property type="protein sequence ID" value="CCC80087"/>
        <property type="gene ID" value="lp_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3030"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2533"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_4_2_9"/>
    <dbReference type="OMA" id="FNDSHAL"/>
    <dbReference type="PhylomeDB" id="F9USF7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2580-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="18728" checksum="5A3F2DAA5BD65481" modified="2011-10-19" version="1">MQIKVDLDDGFLPRIYTSNANVKHSGQPILSFPIEIKSIPAITTAFAISLIDYDAVPRTGFPFIHWLATNIPVMAEIPADFSRNFEGPQGQNSWMSRFYQLNDSYFADHYAGPNPPDQPHRYTLSVFALKHNLPLNNRFYYNDFREQLVGNVLTKAELQILAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH8</accession>
    <name>F9USH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adherence-associated mucus-binding protein,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aapA</name>
        <name evidence="4" type="ordered locus">lp_3059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102023.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890622.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3059"/>
    <dbReference type="EnsemblBacteria" id="CCC80108">
        <property type="protein sequence ID" value="CCC80108"/>
        <property type="gene ID" value="lp_3059"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3059"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2555"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258053_0_0_9"/>
    <dbReference type="OMA" id="WETIING"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2601-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041495">
        <property type="entry name" value="Mub_B2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17966">
        <property type="entry name" value="Muc_B2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394409" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="3">
        <location>
            <begin position="934"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1356" mass="145135" checksum="50ADD6401BDFD582" modified="2011-10-19" version="1">MRYTRGKWRVTNPKVWLFSSVLILGWRIVPTVAQASEAETVTMSSHSVQLETDNQDQLTEVARISKTAVTRDSHSVTAQSSKSADRTSSEQPATTGTVEAVSPTTSEAQQRSTQQDKTAVDQQASDSTAASAGASTNQASAATSSDQAPAANSTGTHHAIDMASSASALGADSGAHSESLSEAQHSGGQGKTIDSDLSGTVHSQSSVSTVTTATPVNSNSSLESDKFTSTRSRAVAATDQMSSRVEKRALNKTNVTKSINIPVATKQPSKQRTVTASSFLTTAKNLADKNYLDQYAKQHGQAALIALIQDWLSTYRIIALTGITIVNSSFDGSVATISGGLHVINTGATIRSGQDDEWETIINGGLSVTNNTITFTTTNGLVDRPVANQDMDFTKPRPTGNGAIKGLPSVTVDSSLINAQEFSQAQINISDFYDQLVTAGTILSATNGGTLSKMLIGESGTADLGSYQGHHYYAVNIDLNDWHSGIRTTGFNNDDVVIYNVVTAAPALTIGGGFSSSTPNLVWNFNHAMRIQNTTMITGKIVAPHAVFTTNQNVDSAAVLQYGYGDVDSAIRETITSQNEHNYGFGQVVTDDPLDYLIAVIKSDGTSIDTLAGFRHLLATGQLKITITDAAGTRLSGLNAVDTHIAGQHCYLITYQFGDQTATTWLNVQPSHEPIIPISRIPEYSAITRTINYQDERTGAVLAGPVIQNVRVVRFAIFNAKTHELLGYDTNGDGIVDTSDGTIAWLLVPPTDQDWVQVVSPDLSAQGYQAPDIPVVAGQTVIINGGDRTMNTNVIVKYQQQTHIATTQRTVTRTINYIDGGTLQPIASLHAVVQTVKYQLLAVVAHDGTILGYDTNGDGQIETQLADEAWLIVGSGPWFGAVKSPDLSHEGYAAPDLKVVPEQMVAGVDDKDVTINVYYRLATQAVTVYQNKRRVISYIDRQTHQSIATTVQQLVIYQRTAIIEKKTGKCLGYDLNGDGLVDTSQADYAWILVGSGQFAAVTSPTLVVQGYTDPDIRTVAAQTVAITDPDLMTTIVTYDHRIITVTPGNPARPGQPVDPDNPNILFPDEGGDTDLTHTVTRIIHYVYEDGTTAAASVLQTVQFQRNAMIDLVTGEVTYQEWVPVSVTEMAGVISPIVAGATTTLTEVAAQQVSVTTADQVVVVTYKKSAIKPEEPGQPEQPSQPEEPGQPEQPSQPEEPGQPEQPSQPEEPGHPEQPSQPEEPGQPEQPSQPEEPGQSEKPGELQKPSQPADSEQPDGLSDQANLSRNQAEQSRTSQPSQAESDQSVVQTNQQKTAASVSGIGWVSGPAVSKRTTKHHRMTTLPQTDEQNTQLSLLGMIGLALSSILGWLKIKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ5</accession>
    <name>F9USJ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890639.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USJ5"/>
    <dbReference type="STRING" id="220668.lp_3079"/>
    <dbReference type="EnsemblBacteria" id="CCC80125">
        <property type="protein sequence ID" value="CCC80125"/>
        <property type="gene ID" value="lp_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3079"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2572"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_9"/>
    <dbReference type="OMA" id="LMEHREV"/>
    <dbReference type="PhylomeDB" id="F9USJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2618-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12284" checksum="F33E14E53F574691" modified="2011-10-19" version="1">MKQTQLLKGVLDGCVLAIISDHEIYGYELIQALREDGFDSIVGGTLYPLLAKLENRGDLIGQFKTSPDGPQRKYYAITPQGLQTLTAFNHQWFQLKAHVDHILTRRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV5</accession>
    <name>F9USV5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888200.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0133"/>
    <dbReference type="EnsemblBacteria" id="CCC77686">
        <property type="protein sequence ID" value="CCC77686"/>
        <property type="gene ID" value="lp_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0133"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.110"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_4_3_9"/>
    <dbReference type="OMA" id="REMTCGE"/>
    <dbReference type="PhylomeDB" id="F9USV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-108-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13861" checksum="D51C0DEF4BA9F813" modified="2011-10-19" version="1">MASCLFCYLSLNMMLIQCIVSFMNIEISKQDQADQQRVAIFKALADANRLRIIRVLYQAQREMTCSEVGAQLNISKSTISYHFKTLRLVGLTNTRRKAQTKYLSLQLATFDRFLPGFLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT00</accession>
    <name>F9UT00_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Raffinose-6-phosphate hydrolase &amp; stachyose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641784.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888245.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UT00"/>
    <dbReference type="STRING" id="220668.lp_0189"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77731">
        <property type="protein sequence ID" value="CCC77731"/>
        <property type="gene ID" value="lp_0189"/>
    </dbReference>
    <dbReference type="GeneID" id="57027018"/>
    <dbReference type="KEGG" id="lpl:lp_0189"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.156"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="OMA" id="YSTARDV"/>
    <dbReference type="PhylomeDB" id="F9UT00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-153-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="15"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="558" mass="64583" checksum="C6684BC734BF85CA" modified="2011-10-19" version="1">MAATIKWWQQAVVYQVYPRSFQDTNHDGIGDLKGITAHLDYLKQLGIDVIWLNPIYRSPNDDNGYDISDYQQIAADFGTMADFDELLQAAHDRGLKIIMDLVVNHTSDEHPWFKRSRQDRTNQYRDFYFWRSGNGKKAPNNWDAAFGGSAWQYDEQTQQYYLHTFSTKQPDLNWENPTLRESVYTMMTWWLNKGVDGFRMDVINQISKLPGLPDGPLKPHSQFGDARVTNGPRVHEFLQEMNQEVLSQFDIMTVGETHGVTPADALKYAGADRHELDMVFEFQHLRLDNSQHGLGKWSTRKTPLVALKKVISDWQVGLEGRAWNSLFWNNHDTPRAVSRFGDDRPAYRVRSAKMLATCLHILQGTPYIYQGEELGMTDAHFTELTSYRDIESLNAYRDLVTERQLLSPADMMARLAARSRDNSRTPMQWDTEVNAGFSDAAPWLTVNPNYRQINAAAALADPDSVWYYYQHLIQLRHQYPLVTLGSFELLWADDPQVFLYARQWEGRTWLVCCNFTAETLSRPLDQYLTPTAKCLISNYGEQQPNKLRPYEAWVYQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT86</accession>
    <name>F9UT86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890718.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80204">
        <property type="protein sequence ID" value="CCC80204"/>
        <property type="gene ID" value="lp_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3173"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2652"/>
    <dbReference type="eggNOG" id="ENOG5033C2F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813262_0_0_9"/>
    <dbReference type="OMA" id="STIWSIV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2692-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="345" mass="38009" checksum="38A28EA1250829D0" modified="2011-10-19" version="1">MKRWMWIVFAVIIAVGVGSYSYTRYRLQEDSYTAEMRTGERALQERNYTLAETSFTHATRTKASSTEAQRYLTQTQTYVAGQEALAARKFDVAKRDFMTVKTTKHGAVTLINQAQEQLTLIKKVQQKRKTYQQQYQKAAELNKANEFTDSNVVIAKLLQDKAFKQRYYQDIRKNVLDLQKQNNASLKTLTGSAPVIPSAAQAVTGMTGSQQQTQRTPATKQQAAASSSTSSANHSMGSSAAANNSYGDSQVQTTRAELTAQGLDGSSYSDAQIRAILQRAAAQHLSLAQAAQTMNYSSDQIQATRAELAQAGFNASQYTDAQIEAILQQASLQHMSLAQAARSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT98</accession>
    <name>F9UT98_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dacA1</name>
        <name evidence="17" type="ordered locus">lp_3189</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890730.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3189"/>
    <dbReference type="MEROPS" id="S11.006"/>
    <dbReference type="EnsemblBacteria" id="CCC80216">
        <property type="protein sequence ID" value="CCC80216"/>
        <property type="gene ID" value="lp_3189"/>
    </dbReference>
    <dbReference type="GeneID" id="57026478"/>
    <dbReference type="KEGG" id="lpl:lp_3189"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2664"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_8_2_9"/>
    <dbReference type="PhylomeDB" id="F9UT98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2704-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389125" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="318"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCC80216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="444" mass="46972" checksum="A322915CB847F66B" modified="2011-10-19" version="1">MRFAGKLKKVMIALVAAVTFSTAGLGIAGADLQAQAASTPSISAKAAIAVDASTGQILYDKNSSKPMAIASMTKMLSTYLVLKAIHEGKLSWNQKISVSKAVAKMSQNTEYANVPLLSTKTYSVRQLYNATEIYSANAAITALGDAVAGTPHKFVSLMRKTAKSWGITDATIINASGLTNKEVGSTIGYSNVAASAENEMSAQDVATVAQKLLSDYPEVLKTSSIAHAWFEKGTSSATKMDNRNYMLKGLVKHYSALPVDGLKTGTSTKAGNAFTGTVKFSNGNRIITVVMHAGAANDSGTERFTQTAEIMSYVYHNYTTTTINKNGKINGVKAVDVQDGKSLTSQLVSNSGATKIYLPTGTDASAVTGKVSLKKSATTDGKLQAPVKNGKTVGTVNLNLSKKAIKVVDGTTSKNMTINVTPKKSIDKANIFVRMWRGVKSWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF4</accession>
    <name>F9UTF4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890786.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80272">
        <property type="protein sequence ID" value="CCC80272"/>
        <property type="gene ID" value="lp_3257"/>
    </dbReference>
    <dbReference type="GeneID" id="58789815"/>
    <dbReference type="GeneID" id="66450787"/>
    <dbReference type="KEGG" id="lpl:lp_3257"/>
    <dbReference type="eggNOG" id="ENOG5030AUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3026622_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2760-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="6305" checksum="128B4F0923FF5BE4" modified="2011-10-19" version="1">MEKTYRTKTYGEMPLKLDTGKGWIFPKGVEVKAHVDLETGQVSFFIAPEDLDKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF8</accession>
    <name>F9UTF8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface hydrolase, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
        </source>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80276.1"/>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="313" mass="35893" checksum="32E71931B61E45A1" modified="2011-10-19" version="1">MKKTRAVAGISAPVAIFSAALFASEKLYDFAFKRVDYVPETSADKQKYADAYYAYVDWLHRQPVQQWQLNANDEANHLVAQYVPAKTTSNRTVIVSHGYKGDGETMANYAYMFHQMGYNVLLPDDRGHGQSAGKYISFGWQDRRDYLGWIDKVVRINGRHTDIILFGVSMGGATVEMMSGEELPSQVKAIIADCGYSSIEEELAYLLKRQFHLPKYPFVPIVSFINRHRMGYYLSDVSSVEQLKHNHLPIFFIHGDKDVYVPSWMLKENYQAAKGPKQMWQVPNATHAESFWIDPAEYQRHVTAFLNHYVPDK</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <dbReference type="RefSeq" id="YP_004890793.1">
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    <dbReference type="EnsemblBacteria" id="CCC80279">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR015046">
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="109" mass="12654" checksum="3C7DF9D99B126538" modified="2011-10-19" version="1">MDVDAQKLFTLVDAAYNQPITNQPSDSYRQALLAAAIDLNNNVSPQQVTIQLYQAYYRNYMVPMTLPRQHRDLYQYVHTQLQRLTRKEQRHMALGYGLIATHLTFGPLN</sequence>
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    <accession>F9UTM6</accession>
    <name>F9UTM6_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80344.1"/>
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            <dbReference type="EMBL" id="CCC80344.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="118" mass="13561" checksum="ADF17C3C454DF344" modified="2011-10-19" version="1">MMGVTQMDQFTAFMAQLDKTLAQEQLSSTDLVYVPVTFSFHNQRLQVAINMLQTSFNQGNNVFGVPDILDRIRMLVGLELADRPQSRWPTKMTTQQLTITPHKMVRVIPVDMRAYQVE</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="VEQSHVC"/>
    <dbReference type="PhylomeDB" id="F9UTR5"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="17160" checksum="69ABEA2F9F741C68" modified="2011-10-19" version="1">MWSIKTFSELTTTELYAIYELRVKTFVVEQQRIYQEVDDTDLKAYHVFKTVNQSIIAYARIFTEDDHLSFGRVVVDKNQRGQHLGADLMAHIEQVVQEHYADLPIQIEAQVPVQGFYQHFGFTSSGTPFLFNHTPHIKMTKPARQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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    <name>F9UU44_LACPL</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888478.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0461"/>
    <dbReference type="ESTHER" id="lacpl-LP.0461">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77964">
        <property type="protein sequence ID" value="CCC77964"/>
        <property type="gene ID" value="lp_0461"/>
    </dbReference>
    <dbReference type="GeneID" id="57024259"/>
    <dbReference type="KEGG" id="lpl:lp_0461"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.381"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_3_9"/>
    <dbReference type="OMA" id="VLMFDFR"/>
    <dbReference type="PhylomeDB" id="F9UU44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-385-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="34998" checksum="6F61F951B26EED99" modified="2011-10-19" version="1">MKQSTKFGLKLAGVIGAATYAGTLLGGLAAYQVAMHVSDAQKQQGRERSRAENTEIENFWYFKQPKQQWMIQSFDGLNLVATYIPNPKTIGRLAILAHGLGHSREQMIPYARIFMSLGYDVLMPDARSFGDSQGHTIGYGWLDRLDYERWITMALSQLGLDIDIVLMGISMGAATVMATSGEPLPENVKAIVEDSGYADLYDEAKFRLTHKFHLPAYPIMPVANRLAHVRAGYGFKDGRILQRVIDGGLPILMIHGSKDQTVPVRNAHTLYDQLPQQKGLYIDPDAGHVEAIRTHPDRYQEVLDEFLHEQAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU69</accession>
    <name>F9UU69_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Prophage P3 protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890885.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3387"/>
    <dbReference type="EnsemblBacteria" id="CCC80371">
        <property type="protein sequence ID" value="CCC80371"/>
        <property type="gene ID" value="lp_3387"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3387"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2823"/>
    <dbReference type="eggNOG" id="ENOG5030B7E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169549_4_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2859-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9870" checksum="ABA2AE16B4F08CF7" modified="2011-10-19" version="1">MLLSDEQAQALRDFVYQLTTDSISQAKRDVGASQQWLRKKKAAAYADVSEGTFAGWTKHGLTGHVINGSVLFNKHDIDFYINHNGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU90</accession>
    <name>F9UU90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, DUF1002 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_3411</name>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3411"/>
    <dbReference type="EnsemblBacteria" id="CCC80392">
        <property type="protein sequence ID" value="CCC80392"/>
        <property type="gene ID" value="lp_3411"/>
    </dbReference>
    <dbReference type="GeneID" id="57026638"/>
    <dbReference type="KEGG" id="lpl:lp_3411"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2841"/>
    <dbReference type="eggNOG" id="COG4086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050671_1_0_9"/>
    <dbReference type="OMA" id="EEHEYLG"/>
    <dbReference type="PhylomeDB" id="F9UU90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2879-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009343">
        <property type="entry name" value="DUF1002"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06207">
        <property type="entry name" value="DUF1002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389052" evidence="1">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="322" mass="34176" checksum="5DE0B0CC3C8B4EB5" modified="2011-10-19" version="1">MTKRMSFKFKWVALVATLIVGIGSWQVLAHADSSSDEPIVTLGSSLTSSQKTGTINTLTASLNGADYQTLTVNGDTLVKYLNPSGESFTSSSGVWSSAMIQKTSSGSGINVKILNYNGSNNITTITANQYKNAALTAGITDANIYVTSATPIDGSGALAGVYAAYAKSGNSLNTKQVTAAQDELSTLSGITQANKSKDGYTDSQLNNAVAGAKKEMAQKGSNITKNEITTIVNQQITNNNLTNVITNNQKTEIINLLVKIRDSGALDSSSFKTQANSLMKNIQSNAKGVFSKLNTKENQNLLQKMWSAIVNFFSSIFKSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU97</accession>
    <name>F9UU97_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="4">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pck</name>
        <name evidence="8" type="ordered locus">lp_3418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890913.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3418"/>
    <dbReference type="EnsemblBacteria" id="CCC80399">
        <property type="protein sequence ID" value="CCC80399"/>
        <property type="gene ID" value="lp_3418"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3418"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2848"/>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037428_0_0_9"/>
    <dbReference type="OMA" id="YANPFRT"/>
    <dbReference type="PhylomeDB" id="F9UU97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2886-MON"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="553" mass="61833" checksum="F1D44CA1B85ADDFF" modified="2011-10-19" version="1">MSTKNSYQLADIGRHNPIFSQIRSTVETAFYGNNMHHVDDIAAAYHRATKDPGTVITDLPIYRATDLGLPADAKMLIANTGKVVGRTAQARRILGNPGVSEADMAGRLRQALFASAHKDFITTDVLVGLDEDFIVRAHLAIPDGFANNLLSYMLNFQPITAAYQEMFDRSVAYPEGDIYIYADPTYHDPDYPDGLAIFDPQHNTAAILGMPYFGELKKSTLTLAWSIAHRHGFVACHGGLKAFHFKDKQDQVFAMFGLSGSGKSTLTHAKHGYKYDITVLHDDAFVINRKDGSSVALEPSYFDKTNDYPMTSDETKYFMTIQNVGVTLDDQGRKVLVTEDLRNGNGRTIKSRYASTNRVDKEAAPINAIFWIMKDDSLPPVIKVDDPVLAATFGATLATKRSSAENIIGNVDRNALVIEPFANPFRVYPLSEDYHDFKALFEERHLDCYLLNTGFFGDKKIPKEITLGALEAIVNDTTEWESFAGLEHMQNLKLADFPVDYANADYRNLVATRLGIRANFIDQYQHNNHDQLPHEITDILVHLQDQLKQPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU98</accession>
    <name>F9UU98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3419"/>
    <dbReference type="EnsemblBacteria" id="CCC80400">
        <property type="protein sequence ID" value="CCC80400"/>
        <property type="gene ID" value="lp_3419"/>
    </dbReference>
    <dbReference type="GeneID" id="57026646"/>
    <dbReference type="GeneID" id="66450906"/>
    <dbReference type="KEGG" id="lpl:lp_3419"/>
    <dbReference type="eggNOG" id="ENOG502ZX1X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186801_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2887-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="65" mass="7408" checksum="70659C2507BD015C" modified="2011-10-19" version="1">MELPLSQLSEKLISFEREHHLTDNDLAFGSQLSVERIHNIKSGEATPTQEELQLLKKFMNSKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB5</accession>
    <name>F9UUB5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_3438"/>
    <dbReference type="EnsemblBacteria" id="CCC80417">
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        <property type="gene ID" value="lp_3438"/>
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    <dbReference type="KEGG" id="lpl:lp_3438"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2865"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_1_0_9"/>
    <dbReference type="OMA" id="FKQITKY"/>
    <dbReference type="PhylomeDB" id="F9UUB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2905-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCC80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="89" mass="9951" checksum="9AA251A0E245A999" modified="2011-10-19" version="1">MATTEEYVTSKQIKTRLKRSAGQLDGVLRMMDENRPCEDVLVQLSAVKSSIDKAMKLVIARNINNCVDAMTTADVQNLEHSLDLLLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF3</accession>
    <name>F9UUF3_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.3</ecNumber>
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    <gene>
        <name evidence="1" type="primary">galM3</name>
        <name evidence="1" type="ordered locus">lp_3487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3487"/>
    <dbReference type="EnsemblBacteria" id="CCC80455">
        <property type="protein sequence ID" value="CCC80455"/>
        <property type="gene ID" value="lp_3487"/>
    </dbReference>
    <dbReference type="GeneID" id="66450953"/>
    <dbReference type="KEGG" id="lpl:lp_3487"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2903"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_1_1_9"/>
    <dbReference type="OMA" id="GPAVNWA"/>
    <dbReference type="PhylomeDB" id="F9UUF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2943-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR008183">
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
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        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="38349" checksum="B5E8AE4D918E8FB1" modified="2011-10-19" version="1">MILETKKTVFDQLDGQDVMRYTLVNDHQTRISVLSYGGTWQEFVVNEDGVEHPLIWGLDNMTDYQRVGYCLCQSIGRVAGRIGGAKFKIDDQSYQVDMNEQTHSLHGGNHGFNTLNFEGAFSQTNDSVSVTLKKHINASDDNYPGNMDVAIKFTLDNQDQVSIAFTGDTDAATLFNPTNHVYWNTTDDRTSLAQQKLQITSAAHLEFDDEKVPTGKKLAVKGTAYDFNQAQPVEKALDQLKTENGGIEFDDAYEVAPSAAEPIAIVGDTDDKRQVKIYSDRNSLIIFTANPFDADKEDAHQYNALATEAQTLPDAINHPDFGDIVLRPGAPVTHTIRYQYERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF7</accession>
    <name>F9UUF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="5">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-06" db="PDB data bank">
            <title>Northeast Structural Genomics Consortium Target LpR145J.</title>
            <authorList>
                <person name="Liu G."/>
                <person name="Tang Y."/>
                <person name="Xiao R."/>
                <person name="Janjua H."/>
                <person name="Ciccosanti C.T."/>
                <person name="Wang H."/>
                <person name="Acton T."/>
                <person name="Everett J.K."/>
                <person name="Montelione G.T."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 348-498</scope>
    </reference>
    <reference evidence="5 6" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643070.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2LFC">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=348-498"/>
    </dbReference>
    <dbReference type="PDBsum" id="2LFC"/>
    <dbReference type="SMR" id="F9UUF7"/>
    <dbReference type="STRING" id="220668.lp_3491"/>
    <dbReference type="DNASU" id="1063007"/>
    <dbReference type="EnsemblBacteria" id="CCC80459">
        <property type="protein sequence ID" value="CCC80459"/>
        <property type="gene ID" value="lp_3491"/>
    </dbReference>
    <dbReference type="GeneID" id="57026705"/>
    <dbReference type="GeneID" id="66450957"/>
    <dbReference type="KEGG" id="lpl:lp_3491"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2907"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_1_9"/>
    <dbReference type="OMA" id="PRGANTG"/>
    <dbReference type="PhylomeDB" id="F9UUF7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2947-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2LFC"/>
        </source>
    </evidence>
    <sequence length="763" mass="83347" checksum="8794A357E52CE955" modified="2011-10-19" version="1">MSKKQITGQAMGHNGIINYEVDVQDNKIEDLKILKHSETSGIFNQVIDKLKQNIITEQSFNVDTISGATVMTQALLKSADKAVTDAGVDVQPVPKKKAPKTQNLRTDVLIIGGGEAGLVAGCRALTMGQKVILVEKNGYLGGATILNGSNVVGTGSDVAAQIFDNNHDTPEMLAQDVARESLETNYPALTDLMVHNIGPAIDFISKFADLHYQKAQTQTPEHSINRQIELPSASSYEFIQKVSKAFAAAGGQIMLDTRVEKLMLDNDKKLRGVIAAQKDQTVNIKARSVVLAAGGHGANQKMRGTESEGIDYYGPMTSTGDAYQFNGDLDLQTHDLGWYKLYPHGVEVEPGVAKLTTYASKQATDMGAIYVNSKGDRIVNESNVYTTFRNAILKQADKVAYLVMDERTWKKVYDLLILHDFTPEEIKSFFENKGKRPVFVKGSLESAAEQAGIVVDELVQTVKNYQGYVQDGHDHDFGRDPKYLHQFEGETFYIIEQRDRFATTLGGYSVDADNLQLVTTKNAPVANYFGAGEIIGGANGHDSMPSMMNTWGISSGYVAGAAASENAQRQATAGDDEANIVAIVGTNASKSYNRKLLYAMKELFETQVNFEICEIKDLPLFNEDDMDREPASVKALAAKIEAADGVVFGVPEYDHSIPAALKSAIEWLSCAEHPFKDKPVMIVGTSLGIQGTVRAQMNLRQILDSPGVDAKVMPGNEFMLPQAGNKFDENDHLNDDGSEHFLKQCFGHFLEGLELASKKTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ5</accession>
    <name>F9UUJ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate symporter, GPH family,maltose-isomaltose (Or trehalose), not sucrose</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891011.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3533"/>
    <dbReference type="EnsemblBacteria" id="CCC80497">
        <property type="protein sequence ID" value="CCC80497"/>
        <property type="gene ID" value="lp_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3533"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2945"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030246_0_0_9"/>
    <dbReference type="OMA" id="NVCMQPF"/>
    <dbReference type="PhylomeDB" id="F9UUJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2985-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="473" mass="52277" checksum="9BD8FC1BB697F468" modified="2011-10-19" version="1">MNQPAVHPNKPIADVSSKPKTSTIANSLPNLPLKTIFAITFGFCGVNMAFSLQSSQMSRIFQTIGADPTKLGLFFILPPLAGLFVQPLVGKYSDRTWTRFGRRMPYLLFSAPLAALVMVLLPNAGSFGFGYASTAALLFGAIAILFMDLSSNVCMQPFRMIIGDMVNENQKDKAWSWQQAFSNLGGVLATILPFVLTYFGVANTAQKGVVPLSVRIAFYIGAIILLGISAYTIHTVKEYDPDTYALYHHINPEQHKHTKPIWQLVKEAPKAFWEVALVQLFAWIGIQYMWTYTTGAIAENVWHTTNAASAGYQAAGNWYGILTFIQSMAAVLYGFLVLSRTNPYKRKFWYRFGLASFAVGLVWVFFIHNQYLLIAPFCLIGIGFFTVHVEPFNIFTSSLDGANEGSYIGIFNGTICLPQILASVASFMVFKFVGNSMPGMMLIAGISMFIAVLAISIIKQDNPQEDLSENPTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>P77887</accession>
    <accession>F9URI1</accession>
    <name>PYRDA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Dihydroorotate dehydrogenase A (fumarate)</fullName>
            <shortName>DHOD A</shortName>
            <shortName>DHODase A</shortName>
            <shortName>DHOdehase A</shortName>
            <ecNumber>1.3.98.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pyrD</name>
        <name type="ordered locus">lp_2699</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2003-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kammerer B."/>
                <person name="Elagoz A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91006.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645881.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77887"/>
    <dbReference type="SMR" id="P77887"/>
    <dbReference type="STRING" id="220668.lp_2699"/>
    <dbReference type="EnsemblBacteria" id="CCC79820">
        <property type="protein sequence ID" value="CCC79820"/>
        <property type="gene ID" value="lp_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2699"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2259"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_9"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="PhylomeDB" id="P77887"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2311-MON"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148397" description="Dihydroorotate dehydrogenase A (fumarate)">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="305" mass="31224" checksum="48DEA6247500E1DF" modified="2003-03-25" version="2">MGRLTVNLAGVTFKNPVMPASGTAAYGQQMAQQLDLSALGGLVIKSTTAEPKAGNPRPTTAETTAGWLNAIGLKNPGIDNVLADKLPWLATHYPDLPIIGSVAGASFDEYVAVARKMASAPNVKLLEINISCPNVDHGGLAFGTDPATVTALTKAIVAAVDKPVFMKLTPNVTDIVPIALAAEAGGAAGLTMINTLTGMGIDLATRQPILAHGTGGLSGKAIHPLAVRMIHDVRQHTKLPIIGVGGVFTPADVLEFYLAGANAVQVGAATYGHPTACTDIIAGLPAAMDQYGITSLQALIQEVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD6</accession>
    <name>Q6LWD6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf41</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222047.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133755.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723591"/>
    <dbReference type="EnsemblBacteria" id="CAG17872">
        <property type="protein sequence ID" value="CAG17872"/>
        <property type="gene ID" value="CAG17872"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17872"/>
    <dbReference type="eggNOG" id="ENOG5033BR8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246520_0_0_9"/>
    <dbReference type="OMA" id="AKHNPEV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3172-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="12271" checksum="BE0864699D31F2BE" modified="2004-07-05" version="1">MKKPSWVDLGNIYRFPKAGLNFKEIGHLSKLDQNKISDFTLDLKSKRRSKGQKIIQQRSSKRKHKESKAELTQRIQKQLKDFAKHNPEIKPKNNPENKNDRPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH1</accession>
    <name>Q6LWH1_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
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                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.45723556"/>
    <dbReference type="EnsemblBacteria" id="CAG17837">
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        <property type="gene ID" value="CAG17837"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17837"/>
    <dbReference type="HOGENOM" id="CLU_2585313_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3137-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="80" mass="9182" checksum="F57671339D0EE8FA" modified="2004-07-05" version="1">MLRSVACVHLGHTQSYNNQCCHLTYSKKPPTSEWLFGCVVDCKIFLVSAQLIQFSNYDNTTLTNHNLDNSMFHLKAKPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH2</accession>
    <name>Q6LWH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222016.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133719.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723555"/>
    <dbReference type="EnsemblBacteria" id="CAG17836">
        <property type="protein sequence ID" value="CAG17836"/>
        <property type="gene ID" value="CAG17836"/>
    </dbReference>
    <dbReference type="GeneID" id="39466575"/>
    <dbReference type="KEGG" id="lpl:CAG17836"/>
    <dbReference type="HOGENOM" id="CLU_157894_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3136-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035528">
        <property type="entry name" value="DUF5388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17363">
        <property type="entry name" value="DUF5388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="116" mass="12996" checksum="7D696AE43E4AA7A1" modified="2004-07-05" version="1">MVELLHNPNSNKSKIIPRKSAPQPQKEISISSLNESNKTKSKQIDGVTFDTTLRIDNHLKNFMKAMVILGYSSTQQNGLAQLQKTFFESLTESEQNTLTTQIQTLETGDANKVKSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U41</accession>
    <accession>F9URH6</accession>
    <name>ADDA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase/nuclease subunit A</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent helicase/nuclease AddA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">addA</name>
        <name type="synonym">rexA</name>
        <name type="ordered locus">lp_2693</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -&gt; 5' nuclease activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of AddA and AddB/RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. AddA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101882.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890329.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U41"/>
    <dbReference type="SMR" id="Q88U41"/>
    <dbReference type="STRING" id="220668.lp_2693"/>
    <dbReference type="PRIDE" id="Q88U41"/>
    <dbReference type="EnsemblBacteria" id="CCC79815">
        <property type="protein sequence ID" value="CCC79815"/>
        <property type="gene ID" value="lp_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2693"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2254"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_3_1_9"/>
    <dbReference type="OMA" id="KQSIYRW"/>
    <dbReference type="PhylomeDB" id="Q88U41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2306-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01451">
        <property type="entry name" value="AddA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF48">
        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02785">
        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000379285" description="ATP-dependent helicase/nuclease subunit A">
        <location>
            <begin position="1"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="1">
        <location>
            <begin position="521"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01451"/>
        </source>
    </evidence>
    <sequence length="1249" mass="141029" checksum="0C270367B7E0ECF3" modified="2003-06-01" version="1">MSEGTNYTPSQQAVIAQQGNNLLVSASAGSGKTTVLIERIMRKILAGTNIDQLLVVTFTNLAAKHMKQKLESQINKRISQLMTDNPAQTTASPAIRQLRQQLNLLGVANISTLDAFCLRVIQRYYYVIDLDPVFRLLTDNTEGLLIRDQVWDSVREQLYDEDGTLFDLLTANFSNDRSDDGLSRLIFRLFDFAQSTPDPEGWLSKLPEPYQVDEEALTASAFYQQQLLPLLINEVDGMQMKLRQAQKVATDADLVPKTLEVLATAQKTLTTLREQLATASWNELRTQVATFKIGALKKTYKDEPEKTARAKTMGTFVDGVKKQMTTLSETYFAADEQQVLDIMVGAKSIVTELVDATKQFKTAFAAEKRRRHVLDFSDLEHLTLQILTSDNESSQAALAQLRAQFEEVMVDEYQDINSLQESILQLLARDQPGNMFMVGDVKQSIYQFRLADPLLFLHKYHDFGTNPEHGERIVLAENFRSVANVDHLTNLIFSQLMDAPVGQIDYDEAAYLKYGPKDYPADMPQTTNLLLYQTETDKSTEDVSTDETNFSIDDPAVGSITMVAQKILALKAQDKPIYERANGEYRPFRYSDVALLVPTRNHNLTIIDVFKRYHIPVVVNDAQNYFQTTEIRIMMALLSIIDNPYQDIPLVAVLRSPIVGLDENQLVYLRIQNKTSDYFQAVQDFYHHYPTGPATEYGDQVYAKIETFLTQLTEFRDLARRNQIVTLIWQIYERTGFLDYVGGMPAGKQRQANLHALYERAYTYEQGSFKGLFQFVRFIRRMQEKDQDLAAAVAETDAEAVNVMTIHGSKGLEYPVIFVMDMDKQFNQTDTRSSALLDREAGIGITYLDPETRVKYPTLPQVVTKQVVSKKMRAEEMRKLYVAMTRAQQQLYLVGTIKDIDTATEKWRQAFASDGRVLSAQARIAATNQLDWVGMAVMRHPAMKAYWGDEWPNYELTDDPTKLAVELGDATTVLAEQSEAVTDTQPDALELVEQQVTIDVDQVTRDYLTTLLNFHYPHQASTTTTAYQSVSEVKRIFEDPDTPLMNANPTVSQRRSRPTSRFVTGSLELPQFLQTTQAPTSAEVGSATHLVLEQLDLTKPVNETTVQSTIDGLVANRVLTTNVAKLIAVDTIVAFYQSALGSQILDNPAKVHREVPFSLLIPARQIFDVDEHETGKVLIHGIIDGYLETADGLTLFDYKTDHVKRPEDLKTRYAGQVKLYAAALASMYPGKVTKQYLYSLPQQVFVPVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UX4</accession>
    <accession>F9UQN2</accession>
    <name>THII_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiI</name>
        <name type="ordered locus">lp_2325</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890035.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UX4"/>
    <dbReference type="SMR" id="Q88UX4"/>
    <dbReference type="STRING" id="220668.lp_2325"/>
    <dbReference type="PRIDE" id="Q88UX4"/>
    <dbReference type="EnsemblBacteria" id="CCC79521">
        <property type="protein sequence ID" value="CCC79521"/>
        <property type="gene ID" value="lp_2325"/>
    </dbReference>
    <dbReference type="GeneID" id="57025858"/>
    <dbReference type="KEGG" id="lpl:lp_2325"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1966"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_9"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="PhylomeDB" id="Q88UX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2005-MON"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154844" description="Probable tRNA sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <sequence length="405" mass="45432" checksum="DAB424DC633F87C0" modified="2003-06-01" version="1">MQYTEIMVRYGELSTKGKNRRNFIDSLGRNVRKALHDFPELKVHANRDRMHIMLNGEDADKVMGRLKLVFGIQNFSPSIRVDADMDAVYETAIAMVKAQFKPGMTFKIYTRRSDHQFEYDTNQINDMLGGQILDHVDGIQVKMKNPDIVLRVEVRLNGIFLSSETIQGAGGLPVGTAGKGMLMLSGGIDSPVAGYLGMKRGVDMEMVHFFSPPYTSEQALAKAKQLASTLASYSGSVKFIQIPFTEIQEEIKEKVPEGYLMTVQRRLMMRLMDAITRQRHGKAIFNGESLGQVASQTMDSMIAINDVTTLPVLRPVISMDKTEIIKIAEDIDTYDLSIMPFEDCCTIFAPPAPKTHPKLDRSRSYEERIDVEGLMARALAGVKMTEIKPGENYLNTQEDVFAELL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V67</accession>
    <accession>F9UQE0</accession>
    <name>RS14_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsN</name>
        <name type="synonym">rpsN2</name>
        <name type="ordered locus">lp_2216</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V67"/>
    <dbReference type="SMR" id="Q88V67"/>
    <dbReference type="STRING" id="220668.lp_2216"/>
    <dbReference type="EnsemblBacteria" id="CCC79429">
        <property type="protein sequence ID" value="CCC79429"/>
        <property type="gene ID" value="lp_2216"/>
    </dbReference>
    <dbReference type="GeneID" id="57025739"/>
    <dbReference type="GeneID" id="66449964"/>
    <dbReference type="KEGG" id="lpl:lp_2216"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1871"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_0_9"/>
    <dbReference type="OMA" id="RLNNRCR"/>
    <dbReference type="PhylomeDB" id="Q88V67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1890-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269051" description="30S ribosomal protein S14">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <sequence length="89" mass="10140" checksum="3A6CD6FEE461F6A2" modified="2003-06-01" version="1">MAKKSKIAKEKRIEATVAKYAERRQALKAAGNYTELAKLPRNASPVRIHRRDSLDGRPHAYLRKFGMSRLNFRRLAHAGQIPGVKKASW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V75</accession>
    <accession>F9UQD2</accession>
    <name>MRAZ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">lp_2203</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644614.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V75"/>
    <dbReference type="SMR" id="Q88V75"/>
    <dbReference type="STRING" id="220668.lp_2203"/>
    <dbReference type="EnsemblBacteria" id="CCC79421">
        <property type="protein sequence ID" value="CCC79421"/>
        <property type="gene ID" value="lp_2203"/>
    </dbReference>
    <dbReference type="GeneID" id="57025730"/>
    <dbReference type="GeneID" id="66449955"/>
    <dbReference type="KEGG" id="lpl:lp_2203"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1862"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_9"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="PhylomeDB" id="Q88V75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1882-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000108490" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="141" mass="16147" checksum="CCAD311203A15C6F" modified="2003-06-01" version="1">MFFGEFEHALDAKGRLIIPAKFRELLGTSFVITRGMDGCIFGYPAERWATLQAQLDDLPLTRKDARAFVRFFYAAAAECELDKQGRVMIPATLRQYAKLEKQCVIVGVSDRFEIWGAEHWQQFETETAANFDDLAENLIDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V90</accession>
    <accession>F9UQB7</accession>
    <name>DAPF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diaminopimelate epimerase</fullName>
            <shortName evidence="1">DAP epimerase</shortName>
            <ecNumber evidence="1">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapF</name>
        <name type="ordered locus">lp_2185</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644607.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889920.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V90"/>
    <dbReference type="SMR" id="Q88V90"/>
    <dbReference type="STRING" id="220668.lp_2185"/>
    <dbReference type="EnsemblBacteria" id="CCC79406">
        <property type="protein sequence ID" value="CCC79406"/>
        <property type="gene ID" value="lp_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2185"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1847"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_1_9"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="PhylomeDB" id="Q88V90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1867-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000149845" description="Diaminopimelate epimerase">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <sequence length="332" mass="35962" checksum="1D5FF6C6E05441E0" modified="2003-06-20" version="1">MAVKMIKVHGSGNDFYLLDQTQFQAPLSDADLKQLAINICKRDGAGLYDGADGVLVVDKSEHPQVLGRMRVINADGTEASMCGNGLRTVARYLGTQNSQEDFRVQTMYADLKVQAVADFAAHVPAYSVEISPVTFDAQTLGMHANNDATTIINEKIPALSADLKFSAVAVPNPHLIAFVDHDTLVGPELGRIGEWMNDGKNQIFPDGVNVSFVEVLGPNSIFVRTFERGVGFTNACGTAMSASSLMYVLLHQESTDFNQEIHVTNPGGMVKTVVHQGADEEYWMELIGNATFVRIVTLPLEDALQGDYSPVTATETGEQVAYEDFVANLAKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W10</accession>
    <accession>F9UPJ5</accession>
    <name>Y1865_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0346 protein lp_1865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1865</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0346 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640574.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889648.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W10"/>
    <dbReference type="SMR" id="Q88W10"/>
    <dbReference type="STRING" id="220668.lp_1865"/>
    <dbReference type="EnsemblBacteria" id="CCC79134">
        <property type="protein sequence ID" value="CCC79134"/>
        <property type="gene ID" value="lp_1865"/>
    </dbReference>
    <dbReference type="GeneID" id="57025461"/>
    <dbReference type="GeneID" id="66449693"/>
    <dbReference type="KEGG" id="lpl:lp_1865"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1571"/>
    <dbReference type="eggNOG" id="COG4479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177534_1_0_9"/>
    <dbReference type="OMA" id="WLMTNRN"/>
    <dbReference type="PhylomeDB" id="Q88W10"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1596-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01538">
        <property type="entry name" value="UPF0346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010673">
        <property type="entry name" value="UPF0346"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023089">
        <property type="entry name" value="YozE_SAM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036806">
        <property type="entry name" value="YozE_SAM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06855">
        <property type="entry name" value="YozE_SAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037262">
        <property type="entry name" value="UCP037262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140652">
        <property type="entry name" value="SSF140652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000164276" description="UPF0346 protein lp_1865">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01538"/>
        </source>
    </evidence>
    <sequence length="73" mass="8434" checksum="D8E632FACC06A0AE" modified="2003-06-01" version="1">MHKTFYTFLMTQRNPDSTDAIAEFANNAFLDQSFPKQSKDFHELSQYLELNAGYLPTMTVFDDAWQAYLASEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WA5</accession>
    <accession>F9UP98</accession>
    <name>METN1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine import ATP-binding protein MetN 1</fullName>
            <ecNumber evidence="1">7.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metN1</name>
        <name type="ordered locus">lp_1744</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29767"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57932"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101532.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WA5"/>
    <dbReference type="SMR" id="Q88WA5"/>
    <dbReference type="STRING" id="220668.lp_1744"/>
    <dbReference type="EnsemblBacteria" id="CCC79037">
        <property type="protein sequence ID" value="CCC79037"/>
        <property type="gene ID" value="lp_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1744"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1470"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_9"/>
    <dbReference type="OMA" id="VFITHEI"/>
    <dbReference type="PhylomeDB" id="Q88WA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1500-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51264">
        <property type="entry name" value="METN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270316" description="Methionine import ATP-binding protein MetN 1">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01719"/>
        </source>
    </evidence>
    <sequence length="355" mass="38431" checksum="1C04EAF86BEED97C" modified="2003-06-01" version="1">MTEAIIDLKDIAVTFDDGHQVVHAVQDVNLQIQTGDIYGIIGYSGAGKSTLVRVINLLQSPTTGQVVVNGQALQTLSPAALRQARKHVGMIFQHFNLMQSRTVMGNVIYPLLGQKISKQNRRAKALRLLKLVGLTDYAQTYPDKLSGGQKQRVAIARALVTDPQILISDEATSALDPKTTTAILELLQRVNRELGITIVLITHEMQVIKSICHHVAVMADGRIIERGPVAEVFTAPKAPLTVDFVETSTNVRAAIQRITKTIKLSELAAGQELIAFKFVGQSTKQGIVSQLSQTLGVDVNILFANIDQIDGQNVGDMIAIITGDLTAFNAAVTNMSAQGVHTRIINEEVVKGMVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-19" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WK2</accession>
    <accession>F9UP01</accession>
    <name>PLSX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">lp_1628</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889454.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WK2"/>
    <dbReference type="SMR" id="Q88WK2"/>
    <dbReference type="STRING" id="220668.lp_1628"/>
    <dbReference type="EnsemblBacteria" id="CCC78940">
        <property type="protein sequence ID" value="CCC78940"/>
        <property type="gene ID" value="lp_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1628"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1376"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_9"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="PhylomeDB" id="Q88WK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1403-MON"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189892" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <sequence length="348" mass="37409" checksum="6706974BD827BEA3" modified="2003-06-01" version="1">MIKIAIDAMGGDYAPNAVIEGVEQARDLFEDTVFLLYGQRDVINAQLKNRDRIQIINADEVITMEDEPVRAVRRKKHSSIVMAAQAVKDGQADAFFSAGNSGAVLAAGLFIVGRIKGIDRPGLVTVLPVVRNANQSNFVMMDIGANADSKPLNLQQYGVLGTYYAERMMQAKHPRVALLNNGTEDDKGNKVHKAAFELLSQTDGINFVGNVESRDLLNGVADVVVTDGFTGNAVLKSIEGTARSMLGLVKDAVYNTGISGKLGGLLLKNGFNEIRSQMDYSQYGGAVLLGLKAPVVKTHGSSKAPTIVNTIRQIRQMVSTDIVPGVAEYFANQQANQQASVDIPAEND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WL3</accession>
    <accession>F9UNZ0</accession>
    <name>FMT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">lp_1616</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WL3"/>
    <dbReference type="SMR" id="Q88WL3"/>
    <dbReference type="STRING" id="220668.lp_1616"/>
    <dbReference type="EnsemblBacteria" id="CCC78929">
        <property type="protein sequence ID" value="CCC78929"/>
        <property type="gene ID" value="lp_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1616"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1364"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_9"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="PhylomeDB" id="Q88WL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1391-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000082980" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="317" mass="34402" checksum="5AE7AB770C0FED18" modified="2003-06-01" version="1">MTSIVFMGTPAFAAPILESLIKEQYQVLGVVTQPDRKVGRKHVLTASPVKEVAVAHDIPVFQPEKISGSPEMQQIIDLQPDLIVTAAFGQFLPTKLLKAAKIGAVNVHGSLLPKYRGGAPVQYSIINGESETGITIIYMVKKMDAGDMLAQRAIPIEKNDDTGTMFDKLSLVGRDLLLETLPKLIAGEITAVPQDESQVTFAPNIQPEQEVLDFFTKTAVEIDNQVRGMRPAPIAYAVLDGKRTKFWDVTPLADEVVTQAPGQVVRKTKHELVIAAADHTAIAINQLQPAGKPKMTITDYLNGAADKFATGEQVINK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WR0</accession>
    <accession>F9UNU1</accession>
    <name>URK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridine kinase</fullName>
            <ecNumber evidence="1">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">udk</name>
        <name type="ordered locus">lp_1562</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640313.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889394.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WR0"/>
    <dbReference type="SMR" id="Q88WR0"/>
    <dbReference type="STRING" id="220668.lp_1562"/>
    <dbReference type="EnsemblBacteria" id="CCC78880">
        <property type="protein sequence ID" value="CCC78880"/>
        <property type="gene ID" value="lp_1562"/>
    </dbReference>
    <dbReference type="GeneID" id="57025150"/>
    <dbReference type="KEGG" id="lpl:lp_1562"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1314"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_9"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="PhylomeDB" id="Q88WR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1341-MON"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000164476" description="Uridine kinase">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <sequence length="209" mass="24054" checksum="7348D34CF899E17D" modified="2003-06-20" version="1">MTENKHRRPVVIGVTGGSGSGKTTVSNAIYNQLSGQSLLILQQDSYYNDQSEMTMAERHAVNYDHPLAFDTDLMIKQIKQLLAYQPIEKPVYDYEQYTRSDKTIHQEPRDVIIVEGVLILDDQRLRDLMDIKVFVDTDDDIRIIRRIQRDIKERGRTLDSVIGQYLATVKPMYHQFVEPTKRYADLIVPEGGENEVAIDLLTTKVRSIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY6</accession>
    <accession>F9UMK5</accession>
    <name>RL3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">lp_1033</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641252.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888958.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY6"/>
    <dbReference type="SMR" id="Q88XY6"/>
    <dbReference type="STRING" id="220668.lp_1033"/>
    <dbReference type="EnsemblBacteria" id="CCC78444">
        <property type="protein sequence ID" value="CCC78444"/>
        <property type="gene ID" value="lp_1033"/>
    </dbReference>
    <dbReference type="GeneID" id="57024691"/>
    <dbReference type="KEGG" id="lpl:lp_1033"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.871"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_9"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="PhylomeDB" id="Q88XY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-887-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000077111" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <sequence length="209" mass="22697" checksum="5382D79190DD054B" modified="2003-06-01" version="1">MTTKGILGKKVGMTQVFTESGELVPVTVVEVQPNVVLQVKTVENDGYEAIQLGVDDKREVLTNKPAQGHAAKAKTTPKRFIREIRNVELGDYTVGDEVKADIFAAGDAVDVTGITKGHGYQGNIHKDGQSRGPMAHGSRYHRRPGSMGAIINRVFKGKKLPGRMGNHQRTMQNLQIVRADVENNVLLIKGNVPGANKSFVTVKTSVKSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y40</accession>
    <accession>F9UMF1</accession>
    <name>SYN1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Asparagine--tRNA ligase 1</fullName>
            <ecNumber>6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparaginyl-tRNA synthetase 1</fullName>
            <shortName>AsnRS 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">asnS1</name>
        <name type="ordered locus">lp_0956</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y40"/>
    <dbReference type="SMR" id="Q88Y40"/>
    <dbReference type="STRING" id="220668.lp_0956"/>
    <dbReference type="EnsemblBacteria" id="CCC78390">
        <property type="protein sequence ID" value="CCC78390"/>
        <property type="gene ID" value="lp_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0956"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.813"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_9"/>
    <dbReference type="OMA" id="CKQHTVR"/>
    <dbReference type="PhylomeDB" id="Q88Y40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-826-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176418" description="Asparagine--tRNA ligase 1">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="431" mass="48989" checksum="C9CB629A1E5EEEA4" modified="2003-06-01" version="1">METISIINAADHVNEQVKIGVWLSNKRSSGKIAFLQLRDGTATFQGVALKNELGETAFAQLTDLAQETSLWVTGTIHADTRSPFGYELAISQFEVVGTSHDYPITPKDHGIDFLLDHRHLWLRSSRPNAIMRIRNEVIRAVYEFFNDRGFIKIDAPILTGSAPEGTTELFKTDYFGQDAYLSQSGQLYGEAGAMAFGKIFTFGPTFRAEKSKTRRHLTEFWQLEPEMAWMHQDESLEVQEQLVAYLGQAVIDHCPHELAVLDRDVATLQKYTKLPFPRVSYDDAITLLQANGFDVDWGVDFGSPEETFLAEHFDQPVFVLNYPKAIKAFYMQAHPTRDDVVIAADLLAPEGYGEIIGGSERSTDYDYLKERLLASGQDLQDYEWYLDLRKYGSVPHSGFGMGLERFLAWITLQDHVRETIPFPRMLHRIYP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZZ1</accession>
    <accession>F9USW6</accession>
    <name>Y150_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0397 protein lp_0150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0150</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0397 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZZ1"/>
    <dbReference type="STRING" id="220668.lp_0150"/>
    <dbReference type="EnsemblBacteria" id="CCC77697">
        <property type="protein sequence ID" value="CCC77697"/>
        <property type="gene ID" value="lp_0150"/>
    </dbReference>
    <dbReference type="GeneID" id="57026984"/>
    <dbReference type="GeneID" id="66448279"/>
    <dbReference type="KEGG" id="lpl:lp_0150"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.121"/>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120023_0_0_9"/>
    <dbReference type="OMA" id="WWSWVIA"/>
    <dbReference type="PhylomeDB" id="Q88ZZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-119-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01572">
        <property type="entry name" value="UPF0397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022914">
        <property type="entry name" value="UPF0397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000260798" description="UPF0397 protein lp_0150">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01572"/>
        </source>
    </evidence>
    <sequence length="186" mass="20097" checksum="1AB679A019BABED1" modified="2003-06-01" version="1">MQNKQSNSIRTVVATGIGAAVIFVLMKFVAIPTGVPNTQVNVAMGFLALLGAIFGPVAAGLAVFIGHALNDFVTYGSPWWTWVIVDGLIGVAFGLAKNRLKIENGVLGTAKLVWFNIYQIIVNFIGWVLLAPTGDIIIYHEPANKVYLQGVITWIADSISVAIIGTILLVLYARTRTQRGSLTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL45</accession>
    <name>F9UL45_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTS system mannose-specific EIIAB component</fullName>
            <ecNumber evidence="4">2.7.1.191</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">EIIAB-Man</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">EIII-Man</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pts9AB</name>
        <name evidence="20" type="ordered locus">lp_0575</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.191"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.191" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888574.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0575"/>
    <dbReference type="EnsemblBacteria" id="CCC78060">
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        <property type="gene ID" value="lp_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0575"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.478"/>
    <dbReference type="eggNOG" id="COG2893">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="eggNOG" id="COG3444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074797_1_0_9"/>
    <dbReference type="OMA" id="EMIFGKQ"/>
    <dbReference type="PhylomeDB" id="F9UL45"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-491-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013789">
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    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00824">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="18">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-4" evidence="19">
        <location>
            <begin position="154"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCC78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
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    <sequence length="324" mass="35283" checksum="E9CA6DB77F0346BD" modified="2011-10-19" version="1">MVSIIIASHGEFAKGIYQSGSMIFGEQENVQAVTLMPSEGPDDIKAKLEKAIASFDDQEQVLFLVDLWGGTPFNQVNGLFEAHKDKWAIVAGLNLPMLIEAYASRLSMDSAHEIATHIIETAKDGVKVRPEALAPKEEKAAAAATTNNNAGRPGKLEYGLARIDSRLLHGQVATAWSKTVNPTRIIVVSDSVAKDDLRSNMIKQAAPAGVHAHVIPIDQMIKIAKDDKHFGGQKALVLFETPQDALRAIEGGVPIKTLNIGSMAHSVGKVQPNKVLAFDQDDIDTYKKLEQDGVEFDVRKVPSDSKDNMDNILKKAQNMLNEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL90</accession>
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            <fullName evidence="1">Prophage P1 protein 4</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">lp_0627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888619.1">
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0627"/>
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            <dbReference type="EMBL" id="CCC78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="58" mass="7005" checksum="8BE4C8DAD5214019" modified="2011-10-19" version="1">MDNEISKYELIATMKKDIQTFMDSESMLYLKKDSYSTEEYDRMLTEVKDDLKTRLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA0</accession>
    <name>F9ULA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0637</name>
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    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888629.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0637"/>
    <dbReference type="EnsemblBacteria" id="CCC78115">
        <property type="protein sequence ID" value="CCC78115"/>
        <property type="gene ID" value="lp_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0637"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.531"/>
    <dbReference type="eggNOG" id="ENOG5030ADW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1625007_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-548-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCC78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20671" checksum="17C9245E2FC6AFBC" modified="2011-10-19" version="1">MSTQSSSVFAGSTLTDVMNHNSVAPIELSGKVGYSVTLIYKQRHDQARIRIESVPAFLAALPNQNQFFAIELAHRFVGVTTPVIDGDRIMKEPLAMAVKTMPELSQALAAIQDSLDELTIPKEDLKPNDFDDPKKLVAECFDAVLYLLNLIAYVCRGFDLSMQDQLKQRMKKWFKDGVVKHRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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    <gene>
        <name evidence="3" type="primary">araB</name>
        <name evidence="3" type="ordered locus">lp_3556</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3556"/>
    <dbReference type="EnsemblBacteria" id="CCC80519">
        <property type="protein sequence ID" value="CCC80519"/>
        <property type="gene ID" value="lp_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3556"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2966"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_509692_0_0_9"/>
    <dbReference type="OMA" id="ANFMRTH"/>
    <dbReference type="PhylomeDB" id="F9ULB2"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Carb_kinase_FGGY_N"/>
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        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="533" mass="58315" checksum="54748C864454F416" modified="2011-10-19" version="1">MNLVETAQAIKTGKVSLGIELGSTRIKAVLITDDFNTIASGSYVWENQFVDGTWTYALEDVWTGIQQSYTQLAADVRSKYHMSLKHINAIGISAMMHGYLAFDQQAKLLVPFRTWRNNITGQAADELTELFDFNIPQRWSIAHLYQAILNNEAHVKQVDFITTLAGYVTWKLSGEKVLGIGDASGVFPIDETTDTYNQTMLTKFSQLDKVKPYSWDIRHILPRVLPAGAIAGKLTAAGASLLDQSGTLDAGSVIAPPEGDAGTGMVGTNSVRKRTGNISVGTSAFSMNVLDKPLSKVYRDIDIVMTPDGSPVAMVHVNNCSSDINAWATIFHEFAARLGMELKPDRLYETLFLESTRADADAGGLANYSYQSGENITKIQAGRPLFVRTPNSKFSLPNFMLTQLYAAFAPLQLGMDILVNEEHVQTDVMIAQGGLFRTPVIGQQVLANALNIPITVMSTAGEGGPWGMAVLANFACRQTAMNLEDFLDQEVFKEPESMTLSPEPERVAGYREFIQRYQAGLPVEAAAGQAIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF0</accession>
    <name>F9ULF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-rhamnose transporter, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhaT</name>
        <name evidence="10" type="ordered locus">lp_3596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102238.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891071.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3596"/>
    <dbReference type="EnsemblBacteria" id="CCC80557">
        <property type="protein sequence ID" value="CCC80557"/>
        <property type="gene ID" value="lp_3596"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3596"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3001"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_9"/>
    <dbReference type="OMA" id="FMPYIYE"/>
    <dbReference type="PhylomeDB" id="F9ULF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3044-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="66"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="369"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="11"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="442" mass="47791" checksum="44F61B8B1FE09D47" modified="2011-10-19" version="1">MSSNKKESHGSTIAVSITNFLDSGSIVAGASGLTLWTKALGLSSFQVGLLGALSANAFGSAIGALIGGHLSDKYGRKVIYTYDMLVYMLGTIIVAASVNFPMLLAGFLITGIAVGAGVPASWTYISETSESTNRAENIGISQFAWSLGPAIIFAAGVALSPLGVMGNRILFIFLTIVAFIAWRLQSKLDESQVWVEQKQHERATGEKPHPYRDLFSNVINLKSLLFLIGVYMFWNLVAGAMGFFMPYVYETAGGLTNLQANLLQAVLWIFTAVATYVGFARYGDRANHRIFFAVGAAMAVVSWVVLTFAGMNWTSLWIFVAVWGISAGIGAQAWYALWATELFPTKYRAGSQGVMFFVVRGSAGIWSIIFPTILTTMGFKAAGTFMIGLLLVSLIIGVIWTPQTRGKSLEQITKERYGDEFDESDAKDKQTPINSNATGDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH0</accession>
    <name>F9ULH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system, glucitol/sorbitol-specific EIIB component and second of two IIC components</fullName>
            <ecNumber evidence="4">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pts37BC</name>
        <name evidence="4" type="ordered locus">lp_3619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891091.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3619"/>
    <dbReference type="EnsemblBacteria" id="CCC80577">
        <property type="protein sequence ID" value="CCC80577"/>
        <property type="gene ID" value="lp_3619"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3619"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3021"/>
    <dbReference type="eggNOG" id="COG3732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054195_0_0_9"/>
    <dbReference type="OMA" id="HKFIYIT"/>
    <dbReference type="PhylomeDB" id="F9ULH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3064-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011638">
        <property type="entry name" value="PTS_EIIBC_GUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011618">
        <property type="entry name" value="PTS_EIIBC_GUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004702">
        <property type="entry name" value="PTS_sorb_EIIBC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39427">
        <property type="entry name" value="PTHR39427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07663">
        <property type="entry name" value="EIIBC-GUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03612">
        <property type="entry name" value="EIIBC-GUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00825">
        <property type="entry name" value="EIIBC-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51102">
        <property type="entry name" value="PTS_EIIB_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-5" evidence="3">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="35721" checksum="2EA44042BC4E9618" modified="2011-10-19" version="1">MTWKSIRIEHGSGGWGGPLTVTPTSERHKFIYITGGNKPEIVDKIADMTGMEAVDGFKTAIPDNEIALAIIDCGGTLRCGIYPKKGILTVNVLPTGKSGPLAKYIVPERYVSAVGVKQIKSNQGVKFADIVDEVSPVNSESDEKVEGQFDDKKTLTQQMNKPSFIARIGIGAGKVVATFNQAAKDSVQTVINTIIPFMAFVALLIGIIQGSGIGKLFAKLMTPLAGNIWGLLIVGFICSLPFLSPLLGPGAVIGQIIGTLIGVEIGKGNIAPQYALPALFAINTQNACDFIPVGLGLEEAEAKTVEVGVPSVLYSRFLNGVPRVFVAWIASFGLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH3</accession>
    <name>F9ULH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorbitol operon transcription antiterminator,BglG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">srlR1</name>
        <name evidence="6" type="ordered locus">lp_3622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102261.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3622"/>
    <dbReference type="EnsemblBacteria" id="CCC80580">
        <property type="protein sequence ID" value="CCC80580"/>
        <property type="gene ID" value="lp_3622"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3622"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3024"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_5_3_9"/>
    <dbReference type="OMA" id="NNPEERI"/>
    <dbReference type="PhylomeDB" id="F9ULH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3067-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PRD" evidence="5">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="470"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="618" mass="71938" checksum="1918184D9719C617" modified="2011-10-19" version="1">MNNQYLRLLNFFVVNDSVTMDDLVAFAHVSERTMCKYIQRLNDDLAGVAQIQEQRHRYYLQVTDYSRLTKIQMGHLKKELDFNSTDKRDAYILKTLLECHDYVTLDSLAEQLMISKTTLNRDLKRLREQLVTYHAEIKSMTNNGIKLVASRTYEVFAVIDHFIYDYFELSKLLSKKQEEQLKLTLLNNGVDNETSRLILKNISVLKFAFPIGYRIEQPITNFSNYLIDDQPMDDIRSSVVACFSTEISMDELVFVLAPLAFKMTSLLSRKRMKEQIDNNRMLFLSMGNHSSHQIPFDFEHLYEQIKYHLFFLINRTILHVPTAQLLPENQLTKYPLAYDLAHTILGFLETHLDFKITTAEFGYLVLYVEMELEDQDNIVNHKFEIAIVGQVGSSVIKFIRRQLVEMFQDDITVAVFDNEWQLNQDNGRYLLIFSDQPIVYHDETTPVVRISAAFRTNELRGKLQVSLVEKAISNATCQFDLWKFNHDTDYLTAVETMIDARISDGHVDSRFKSRWLEREQRGISVFEKGIAIPHVVNEKDTPEILLQVGVYDQPIKYLDRTVQMIFLIGTPNNLDQELGQVLTQIYDLVFLASNNVNIYDRLIDYNVDANLLQIAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ5</accession>
    <name>F9ULQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0667"/>
    <dbReference type="EnsemblBacteria" id="CCC78144">
        <property type="protein sequence ID" value="CCC78144"/>
        <property type="gene ID" value="lp_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0667"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.559"/>
    <dbReference type="eggNOG" id="ENOG5030AVK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2206678_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-578-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="12118" checksum="11514D86211165BB" modified="2011-10-19" version="1">MRYPDKVYLLTKLPDDDPNGLNHQVSYQSQVVPANMQQVNLTFAPNGTVYNATVIRVYGRYQADAIGLDGEYVEGVNDTVHEIQKVSQHDKQTAFYIIHNEVILHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT0</accession>
    <name>F9ULT0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrdE</name>
        <name evidence="12" type="ordered locus">lp_0693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643938.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888683.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0693"/>
    <dbReference type="EnsemblBacteria" id="CCC78169">
        <property type="protein sequence ID" value="CCC78169"/>
        <property type="gene ID" value="lp_0693"/>
    </dbReference>
    <dbReference type="GeneID" id="66448671"/>
    <dbReference type="KEGG" id="lpl:lp_0693"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.582"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_4_1_9"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="PhylomeDB" id="F9ULT0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-603-MON"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="721" mass="82142" checksum="1C0403871492C1C5" modified="2011-10-19" version="1">MTLKDLKDVTYYDLNNEINIPVNNQIPLNKDQEALAAFLEQNVEPNTMKFDSLKARFDYLREHDYLETPAIDKYDFSFIEKLYDYLRSQDFHFKTFMAAYKFYAQYALKTDDGDYYLENFIDRVAMNALYFADGNEDLAMDLADEIVHQRYQPATPSFLNAGRARRGELISCFLIQSTDDMNSIGRTINSALQLSRIGGGVGINLSNLRGAGDPIKHIDGAASGVVPVMKLLEDSFSYSNQLGQRQGAGVVYLSVFHPDIIAFLSAKKENADEKIRLKTLSLGVTVPDKFYELIKADADMYLFSPYGVEREYGVPFSYVDITKEYDNMVKNPNIRKTKIKARDLENEISKLQQESGYPYVVNIDTANRENPIDGKIVMSNLCSEVMQVQTPSLIDDQQQYEKLGTDISCNLGSTNIVNLMTSPDFGHSVEAMVRALTFVTDHSNVDVVPSIQKGNRQAHTIGLGAMGLHAFFAKNQMEYGSKEAVDFTNIYFLLLNYWTLKASNEIARERHETFVNFEKSKYADGSYFDKYTTQDWQPKYDKTAALFDGIFIPTKADWEALKEAVMRDGLYHQNRMAVAPNGSISYINDTTASLHPIINRVEERQEKKIGKIYYPAPYLSNDTINYYKSAYDTDMRKVIDVYAAAQQHVDQGMSLTLFMRSTIPAGLYEWKDGRTDKMTTRDLNILRNYAYRKGIKSIYYIRTFTDDDGEVGVNECESCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT2</accession>
    <name>F9ULT2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16S rRNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmC</name>
        <name evidence="2" type="ordered locus">lp_0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888685.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0695"/>
    <dbReference type="EnsemblBacteria" id="CCC78171">
        <property type="protein sequence ID" value="CCC78171"/>
        <property type="gene ID" value="lp_0695"/>
    </dbReference>
    <dbReference type="GeneID" id="57024405"/>
    <dbReference type="GeneID" id="66448673"/>
    <dbReference type="KEGG" id="lpl:lp_0695"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.584"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_7_1_9"/>
    <dbReference type="OMA" id="HMIDVNE"/>
    <dbReference type="PhylomeDB" id="F9ULT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-605-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="202" mass="22152" checksum="26C545210DE3E241" modified="2011-10-19" version="1">MTNYYYTHNPDIVHDEKQWNFEIFNHSFKFTTDNGVFSKRTVDYGSRTLLAAFDPTDLPAGPMLDLGTGYGPIGMALAYQSPERTVDMVDVNELALSLARKNVALNQITNTNIFTSDVYQQVTATNYAAIVTNPPVRAGKAVVDAMLTGAVSRLVVGGTLTVVLQKKQGAPSAKKLMQTTFGNCQVIKKDKGYYILQSVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM16</accession>
    <name>F9UM16_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eriC</name>
        <name evidence="7" type="ordered locus">lp_0794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888769.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0794"/>
    <dbReference type="EnsemblBacteria" id="CCC78255">
        <property type="protein sequence ID" value="CCC78255"/>
        <property type="gene ID" value="lp_0794"/>
    </dbReference>
    <dbReference type="GeneID" id="57024496"/>
    <dbReference type="KEGG" id="lpl:lp_0794"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.672"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_7_4_9"/>
    <dbReference type="OMA" id="VLYRRFE"/>
    <dbReference type="PhylomeDB" id="F9UM16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-691-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="430"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="517" mass="56302" checksum="DC263ACC85934C5F" modified="2011-10-19" version="1">MVAQRPHIAKQHFDFTRFSSIGRALIVGVIAGIVVSIFRFSIEQGLRFVQWVYAQIHTNWLLLFPWIGLSVAVAFFVGWLVKNEPNIKGSGIPQVEGQLAGELDYSWWSVLWRKFVGGILGIGSGLFLGREGPSIQLGATIGQGVASKLKQTGSDRRSLIAGGAAAGLSAAFNAPIASTLFVLEEVYHNFSPIIWTTALVSAMASNFISLNFFGLVPVLHIPYGHNLPLSQYGNLIGLGIFLGIFGYLYQNVTLTMPNWYAKLRLPSWLDGLVPFLLVIPIGLIWPQLLGGGNAVILNLAAVTPALLALLGIFVLRFTFSTISYGSGLPGGIFLPILSLGAILGAIYAQFMVAVGWMPTNLIPNFIIFAMAGYFAGIGKAPFTAILLITEMVGTLHHLMPLAVVSMTAYLVVDLLGGAPIYEALLEKLIQPRLPEHSGIQDRLELPIFEGSKLEGHQVRDFKWPAESLLIAIRRGERQVIPHGDTLMRAGDTLIILTDRDNRAWVRHQIAHLTVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM44</accession>
    <name>F9UM44_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose epimerase</fullName>
            <ecNumber evidence="3">5.1.3.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galM1</name>
        <name evidence="5" type="ordered locus">lp_0826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of alpha and beta anomers of maltose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-maltose = beta-maltose</text>
            <dbReference type="Rhea" id="RHEA:21228"/>
            <dbReference type="ChEBI" id="CHEBI:18147"/>
            <dbReference type="ChEBI" id="CHEBI:18167"/>
            <dbReference type="EC" id="5.1.3.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.21" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888797.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0826"/>
    <dbReference type="EnsemblBacteria" id="CCC78283">
        <property type="protein sequence ID" value="CCC78283"/>
        <property type="gene ID" value="lp_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0826"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.701"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_1_1_9"/>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="PhylomeDB" id="F9UM44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-719-MON"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050558">
        <property type="term" value="F:maltose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="349" mass="38950" checksum="14654AA142DB6B48" modified="2011-10-19" version="1">MSGSYGSEGIMKIIEHQGNGINYYTLVNNHHMSVTIMDWGATVTAIKTHDKDGNFANIVLGFDDGADYITYQSFFGATIARVAGIIKNARWRQYDLTQNAGENHLNGGNMPQISFEPWFLERKLHTSDQVGLVMQYITLDGENGYPGTMTITANFVLDNDGKFTISYTGKSDKTTLFNPSNHTYFNLSGDAERLIDHHVLKINADEYAALNKHGIPTGKLPWVTDTPFDFRDPVEVGPQIANIKGGLHHGFVLNDTPYPQVELLDRISGRKVTMRTNAPAVVVSSATNYRDDRYRLNGGKPMRSQLGLSLQAQKLPDAIHHKEFGSIIIEPNIPVTYQTAYRFSNIYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM91</accession>
    <name>F9UM91_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888844.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0887"/>
    <dbReference type="DNASU" id="1062122"/>
    <dbReference type="EnsemblBacteria" id="CCC78330">
        <property type="protein sequence ID" value="CCC78330"/>
        <property type="gene ID" value="lp_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="57024571"/>
    <dbReference type="KEGG" id="lpl:lp_0887"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.751"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_4_0_9"/>
    <dbReference type="OMA" id="GKPCADP"/>
    <dbReference type="PhylomeDB" id="F9UM91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-766-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="28117" checksum="3CDD335F371AAC26" modified="2011-10-19" version="1">MERKVIVRADDLGYSDAVNVGIARTVHNGLINNVGVMVNMPTTMSGLAMIKDAGVCLGLHTVISAGRPLTNPKLIPSITNPDGTFRHSSDYRAAVHDFVDLNEVVLEIEAQYQKFVALVGRQPDYFEGHAVVSDNFVKGLEIVGERHHLNLLRFAAGPDSPSVLFKGKVLHVFMESMGKNYNPYETLKRAALAQYNDGYAMMVCHPGYLDDYLLQHSSLTVPRTQEVAMLTDPQMQEWLERQQIKLIKYSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ7</accession>
    <name>F9UMJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101243.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1020"/>
    <dbReference type="EnsemblBacteria" id="CCC78436">
        <property type="protein sequence ID" value="CCC78436"/>
        <property type="gene ID" value="lp_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1020"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.862"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_8_9"/>
    <dbReference type="OMA" id="QPALYHY"/>
    <dbReference type="PhylomeDB" id="F9UMJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-879-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="22447" checksum="98E36DEE1D816CAA" modified="2011-10-19" version="1">MATRAEQMAKTHQAILDTARELFLRNGYDATSTRDIANAIGITQPALYHHFKDKEVIFLAVITTVGAEIRAGIEAIQVRADWSPLDQLTEVSLLLTHKHPADVFTLIHSSFKALTHEHIRELGGIFVTDYVKPIQTVFEQPDMQLHVGVTPQMATNFYITSLSPLFNSFHQIGDPHADERTRVQTLLKMILYGVASEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR6</accession>
    <name>F9UMR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malic enzyme, NAD-dependent</fullName>
            <ecNumber evidence="6">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mae</name>
        <name evidence="6" type="ordered locus">lp_1105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641301.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889019.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1105"/>
    <dbReference type="EnsemblBacteria" id="CCC78505">
        <property type="protein sequence ID" value="CCC78505"/>
        <property type="gene ID" value="lp_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1105"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.934"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_9"/>
    <dbReference type="OMA" id="MIAQNHE"/>
    <dbReference type="PhylomeDB" id="F9UMR6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-948-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="386" mass="40101" checksum="E0C8916A8E207023" modified="2011-10-19" version="1">MVEQDEILKLHAAHTGVLDIHSDLAVTDKADLGKAYTPGVAVISKLIAAHPELKAKYTMSGKLVALITDGSAVLGLGNIGPAGGLPVVEGKALLYKNLAGINAIPLALNQVSVPAMVATIKNMSLSFAGIHLEDITAPKCFELEAALKDELDIPVYHDDQEGTAIVVLAGLINAAHVVGKSLRQMRIVVNGVGASGLATARLLAAVGVKQLTLVDVYGVVTADDQRYNQYQRNLAKQLGTPAQLKGQPLAKVMADQDVFIGLSDANVLSAGAVHLMNHDPIVFALANPVPEINPAVAEKAGATVIATGSSQYPNQVNNILAFPGLFKGLLTNGVKQVDNALQIQVAQALAKTVSNPTATTIVPSVFDSQVVPNVTAAVAAYAQAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW2</accession>
    <name>F9UMW2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rhe2</name>
        <name evidence="7" type="ordered locus">lp_1162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1162"/>
    <dbReference type="EnsemblBacteria" id="CCC78551">
        <property type="protein sequence ID" value="CCC78551"/>
        <property type="gene ID" value="lp_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1162"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.982"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_9"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="PhylomeDB" id="F9UMW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-993-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="221"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="444" mass="49656" checksum="88FA9ADA9EAAC294" modified="2011-10-19" version="1">MLDVFKTKFAAAGFTELSPIQTAVAEPLAAGQSVLGLAPTGSGKTLAFTWPMLEALRVGEGTQALILAPSQELAMQTTNVVREWGQLIDAKVLAITGGANVKRQMEKLKKHPEVIVGTPGRITNLIADGKIKLGHLKMMIVDEADELLTDETLDQIREILDATFAETLQLGFFSATETKILDELPRWFGQHVEKIDVRAIDQTQGVVRHRTMQVGNRHRVDLLKRISRVDHMRALVFFNKMRELQHVALELRHQHVSYVALTSNQRQVEREKALRLFRQGKVGLLLTTDLAARGLDVPELPAVINYQLPKDVTTYIHRSGRTGRMGADGLVLTFGDDHDVRDFKKLMATTDYEIKPGYLVDYHIVDTKPDKVVPPLTFDHPETAGNAANGRHRVVSAGHPDEVKRVETSRKRPAAATPKKKKGHNKHSKKKGMRKKNRDRFSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY4</accession>
    <name>F9UMY4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ordered locus">lp_1186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889087.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1186"/>
    <dbReference type="EnsemblBacteria" id="CCC78573">
        <property type="protein sequence ID" value="CCC78573"/>
        <property type="gene ID" value="lp_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1186"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1004"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_9"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="PhylomeDB" id="F9UMY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1016-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="31859" checksum="C92EA4CA2F0D6BBB" modified="2011-10-19" version="1">MKGIILAGGSGTRLYPVTKVTSKQLLPIYDKPMIYYPLSTLMLSGIKDILIISTSRDSNSFKALLGDGSELGIHIEYAIQQEPNGLAEAFIIGKQFIGDDSVCLILGDNIFYGNGLSETLQKAVRLKDGAIVYGYRVKDPERFGVVSFDNKKNVISIEEKPTDPKSDFAVTGIYFFDNDVVSIAESIKPSARGELEITDINNVYLKRKKLKVELLSRGFAWLDTGTHESLQDASSFIQTVERRQNILIASIEEVAFRMGYIDSKQLQSLAAPLHKTRYGQYLASLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN43</accession>
    <name>F9UN43_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1251"/>
    <dbReference type="EnsemblBacteria" id="CCC78632">
        <property type="protein sequence ID" value="CCC78632"/>
        <property type="gene ID" value="lp_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1251"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1062"/>
    <dbReference type="eggNOG" id="COG1023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_9"/>
    <dbReference type="OMA" id="NGYALMY"/>
    <dbReference type="PhylomeDB" id="F9UN43"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1073-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="31809" checksum="C7CCB5CC54E1158F" modified="2011-10-19" version="1">MKLGLIGLGKMGMNLALNMQDNGHTPVGMDLNPTNLSTASAHGLATATDLTNLLDQLPTPRIVWIMVPAGKATNSVIEQLAQTLSAGDIVLDGGNSHYQDSIRHGELLASHHINFLDVGTSGGQAGARHDGNFMIGGDLATFQVVEPLFKAIAAPDGYLYTGPVGSGHYLKMVHNGIEYGMMAAIGEGFDVLQHSQFTYDNAAVAKMWNNGSVIRSWLMGLAQDAFSKDGNLDDIKGVMHSSGEGRWTLDTALDQQVATPVIAMALMMRYRSETDDTFTGKVVAALRNEFGGHAVDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN58</accession>
    <name>F9UN58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent Clp protease, ATP-binding subunit ClpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpE</name>
        <name evidence="6" type="ordered locus">lp_1269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101337.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1269"/>
    <dbReference type="EnsemblBacteria" id="CCC78647">
        <property type="protein sequence ID" value="CCC78647"/>
        <property type="gene ID" value="lp_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1269"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1078"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_3_9"/>
    <dbReference type="PhylomeDB" id="F9UN58"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1088-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="5">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="739" mass="81725" checksum="93D51E3A52BC761A" modified="2011-10-19" version="1">MLCDNCHKNEATIHLYTSVNGQRRQINLCQNCYQLLKNQEQQPNNGVGGADMAQDPFGFGGLDDIFRAMQGGVDPNNAYRQQQTPPTQPAGPNGGNRRGNNNGGGLLGQYGFNLTAQAKQGKIDPVIGRDTEINRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQKIVSGQVPQKLLDKEIIRLDVASLVQGTGIRGQFEQRMQQLMKEVQSNPNIILFIDEIHEIMGAGNAEGGMDAGNVLKPALARGDFQLVGATTLNEYRDIEKDAALARRFQPVTVNEPSVEESIKILEGIQKKYEDYHHVKYDQDAIVAAVKLSNRYIQDRFLPDKAIDLLDEAGSRKNLTLKTVDPKTIQEKIDEAEKQKQDALKKEDYEKAAYYRDQVAKLEKAKPDESSDQPNNDTATVTVKDMEQIVEEKTSIPVGDLQAKEQAQMKTLAPDLKSTVIGQDQAVEAVSRAIRRNRIGLNGTGRPIGSFMFVGPTGVGKTELAKQLAKELFGSQDAMIRFDMSEYMEPHSVAKLIGSPPGYVGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDSEANVGFGAAAEGKTHDITSRLTDYFKPEFLNRFDDIIQFNALSKENLMKIVGLMIEDVNGMLANQGLHVHVTEPVEEKLVELGYNPQMGARPLRRVIQEQIEDRIADFYLDHGDVKNMVAKVEDGKIVLAAETKSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN92</accession>
    <name>NNRD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrD</name>
        <name type="ordered locus">lp_1320</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101353.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889195.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UN92"/>
    <dbReference type="SMR" id="F9UN92"/>
    <dbReference type="STRING" id="220668.lp_1320"/>
    <dbReference type="EnsemblBacteria" id="CCC78681">
        <property type="protein sequence ID" value="CCC78681"/>
        <property type="gene ID" value="lp_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1320"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1113"/>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_2_1_9"/>
    <dbReference type="OMA" id="HIPHTNE"/>
    <dbReference type="PhylomeDB" id="F9UN92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1139-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416143" description="ADP-dependent (S)-NAD(P)H-hydrate dehydratase">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <sequence length="278" mass="29787" checksum="7BAC05C9B580074D" modified="2011-10-19" version="1">MQPITTEIVSRTIIKRPADSHKGNYGRIMLIGGNQNFGGAIIMAATAATYSGAGLVTVATDPSNFTSLHARLPEAMVIDYHQTDTLLNLLAGMDVIVIGPGLGTDTVADQLLTAVLAATHVPQRLVIDGSALTLLAQQARPLPATDIVVTPHQMEWQRLSGIAIKDQTPTANHDAQQRLGVMAVVKAHRTTVYTDERVWFNPGGTPAMATGGMGDTLAGMIGGFVSQFHNFTDAVLSAVYLHSAIADDLAATRYVVLPHQISTRIPTYMHRFSQIERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA4</accession>
    <name>F9UNA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101359.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889207.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1334"/>
    <dbReference type="EnsemblBacteria" id="CCC78693">
        <property type="protein sequence ID" value="CCC78693"/>
        <property type="gene ID" value="lp_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1334"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1125"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098606_0_0_9"/>
    <dbReference type="OMA" id="AVSPWEF"/>
    <dbReference type="PhylomeDB" id="F9UNA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1151-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="27056" checksum="9CD3A464B5E70B58" modified="2011-10-19" version="1">MSLSVTKIKALFGLKLRLIISNMSLMTAPIMAILYVVFMKSIMQSKAPSHVALISLLLGMGLCFNIVMGGIMMTSYPLAEEKEHHTLRVLMTSSITGPEFFIGSLLPPLAIMTVTNLILVPLSGASWSQIHLGNFLLITIITSLTSLVLGYIIGLIANSQTQAGVYSIPMMLILSLIPNFEQFNTTLKTISSYLYTSTINHYITASYATNGFSWTLREVLTQLGWLVITCGIFFYAYRRHGLDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC8</accession>
    <name>F9UNC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA2</name>
        <name evidence="15" type="ordered locus">lp_1364</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1364"/>
    <dbReference type="EnsemblBacteria" id="CCC78717">
        <property type="protein sequence ID" value="CCC78717"/>
        <property type="gene ID" value="lp_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1364"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1148"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_9"/>
    <dbReference type="OMA" id="VCFEGTV"/>
    <dbReference type="PhylomeDB" id="F9UNC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1175-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="453"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="487"/>
            <end position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="756" mass="82377" checksum="FA7A7F8BC280C971" modified="2011-10-19" version="1">MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRELNETFPSFTQQYLPKYGQPHVGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLFSRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQLIDPEKSLNEGAITFVSFAPDTWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKRSIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTFLQAIDAPLAQDIVRELTTKIQSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVDMVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHNPAMFTLADYVVEMGPAAGRTGGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLGVMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAKANGVATSWFSYNGKGACPRCKGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGKTIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTLAQPLTTLSGGELQRLKLAVELGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGPDAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC9</accession>
    <name>F9UNC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Ursing B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889336.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1494"/>
    <dbReference type="EnsemblBacteria" id="CCC78822">
        <property type="protein sequence ID" value="CCC78822"/>
        <property type="gene ID" value="lp_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1494"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1256"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_1_9"/>
    <dbReference type="PhylomeDB" id="F9UNN3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1283-MON"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="10">
        <location>
            <begin position="181"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="404" mass="44385" checksum="B0AB6BA19C2EA3AE" modified="2011-10-19" version="1">MLTRRYPISITEAQAKINQVALPTKTETIPVTDANHRVLAETVTAPFAYPHFRRSGVDGFAIRHEDDHDYPHEFKVVGNIPAGSTFHQPLGKDEAVRIMTGADVPSDAGVVVMLEKTRELADNRINIVVPEKHSNITEIGEEYQTADVLIEKDTELNPGGLAGLTALGVQTVTVYRQPRVAVITTGSELMAPGEPVQEGKIYNSNGVQIPYLVRENGGVITNVEQLVDDNALLQASLTKAIAENDIVITDGGVSVGDYDFIGDTARQADELLFNKIKQRPGSVTTAFVQDNTLVMALSGNPGACFTAFYLYVEPLLRRFVHQPSRIKKVQSRLAAPYHKTNGFDRILRATFTEDHGQYATYPNGPDRSGALSNLQTTTCLIKIPHSNRPIELNAEVETWLLPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ8</accession>
    <name>F9UNZ8_LACPL</name>
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        <submittedName>
            <fullName evidence="2">General stress protein, Gls24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638623.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1625"/>
    <dbReference type="DNASU" id="1063719"/>
    <dbReference type="EnsemblBacteria" id="CCC78937">
        <property type="protein sequence ID" value="CCC78937"/>
        <property type="gene ID" value="lp_1625"/>
    </dbReference>
    <dbReference type="GeneID" id="49393892"/>
    <dbReference type="GeneID" id="57025208"/>
    <dbReference type="GeneID" id="66449507"/>
    <dbReference type="KEGG" id="lpl:lp_1625"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1373"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_2_0_9"/>
    <dbReference type="OMA" id="CYGLVGM"/>
    <dbReference type="PhylomeDB" id="F9UNZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1400-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13054" checksum="743692D64BB6735E" modified="2011-10-19" version="1">MAVKIKTQFGTIDIDNDVIATVVGGAATDNYGVVGMASRNQIRDNVNEILRRENYARGVVVRQEDNGVAIDVNIIVSYGTKISEVSRNVQAKVKYNLQNMLGVTANSVNVIVQGVRVMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP59</accession>
    <name>F9UP59_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfa1</name>
        <name evidence="3" type="ordered locus">lp_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640436.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1696"/>
    <dbReference type="EnsemblBacteria" id="CCC78998">
        <property type="protein sequence ID" value="CCC78998"/>
        <property type="gene ID" value="lp_1696"/>
    </dbReference>
    <dbReference type="GeneID" id="57025328"/>
    <dbReference type="KEGG" id="lpl:lp_1696"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1432"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_9"/>
    <dbReference type="OMA" id="LHCITAQ"/>
    <dbReference type="PhylomeDB" id="F9UP59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1461-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="390" mass="44770" checksum="C79E13D687616C7F" modified="2011-10-19" version="1">MLDKIIYKNLFSKAFDITIEVTYWDGQIERYGTGMPAVKVRLNKEIPIKLLTNQPTLVLGEAYMNGDIEVDGSIQELIASAYRQKDSFLTHNSFLKHLPKISHSEKSSTKDIQSHYDIGNDFYKLWLDDTMTYSCAYFEHDDDTLKQAQLNKVRHILNKLATQPGKRLLDVGSGWGTLLFMAADEFGLDATGITLSQEQYDYTQAQIKQRHLEEKVHVQLKDYREVTGQFDYVTSVGMFEHVGKENLGLYFNKIQAFLVPGGRALIHGITGQHEGAGVDPFINQYIFPGGYIPNVAENLKHIMAAKLQFSDIEPLRRHYQKTLEIWYHNYQQVEQQVVKNYGERFDRMWQLYLQACAAAFEAGNIDVIQYLLVKAPSGTGLPMTRHYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP65</accession>
    <name>F9UP65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF805 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889518.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1702"/>
    <dbReference type="DNASU" id="1064127"/>
    <dbReference type="EnsemblBacteria" id="CCC79004">
        <property type="protein sequence ID" value="CCC79004"/>
        <property type="gene ID" value="lp_1702"/>
    </dbReference>
    <dbReference type="GeneID" id="57025334"/>
    <dbReference type="GeneID" id="66449569"/>
    <dbReference type="KEGG" id="lpl:lp_1702"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1438"/>
    <dbReference type="eggNOG" id="COG3152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093674_4_1_9"/>
    <dbReference type="OMA" id="WFIWLGF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1467-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="14226" checksum="70C1460E7EEB7898" modified="2011-10-19" version="1">MASAYRKFWDNLLNFSGTATRSEYWWPVIINYILGGIIIAIIQMIMGHPIEDIYNWSDLSVNTMSKLIALIVWLGTLSLKFRRLHDSDHTAWWILIDLVPIIGTIWFFILMVLPSRSNRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA4</accession>
    <name>F9UPA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_1750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889557.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1750"/>
    <dbReference type="EnsemblBacteria" id="CCC79043">
        <property type="protein sequence ID" value="CCC79043"/>
        <property type="gene ID" value="lp_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1750"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1476"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_9"/>
    <dbReference type="OMA" id="RDRQFLG"/>
    <dbReference type="PhylomeDB" id="F9UPA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1506-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="317" mass="35329" checksum="4EB4B02ECC149901" modified="2011-10-19" version="1">MVAIKLHELSKSFQGPVINQLSLTIPDQQITALIGPSGSGKSTLLNMIAGLTTPDSGQISFDNQPIFDAATHWNQPPAQRHLAMVFQDFALWPHMTVQENVAFALEKHLTKPELTAQVNWALEQVSLIDFRHRYPRELSGGQQQRVALARALATQPDLILFDEALSALDPELRTRLQLEIRALIHDQHLTAIFVTHDRPEALQVADHLVLLQGGNVVQTGTPAQLYQQPKSQFVANFMGTLNQINAHQAIRPEYVAVSQTGTQQPTYQGLVQRSTFMGDHFDTCVQVGAYDWHVKTQLPYTTAPITLSIDPHQILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE0</accession>
    <name>F9UPE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889593.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1792"/>
    <dbReference type="EnsemblBacteria" id="CCC79079">
        <property type="protein sequence ID" value="CCC79079"/>
        <property type="gene ID" value="lp_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1792"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1513"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050687_1_1_9"/>
    <dbReference type="OMA" id="NEHMKLF"/>
    <dbReference type="PhylomeDB" id="F9UPE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1542-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="28772" checksum="1FC00AF7BAF8EC4C" modified="2011-10-19" version="1">MMTLYRQELTKLFKKKSTIWCGLILATVALIFAILARIKPTIFPAKTMFAANFEAQQFIVFFMVAAAATMITMEFQFGTIKHVLTQRYSRPLVLVSKWLVLLTYSLLLYVGSSLFAILLKVCLVNDKFAIFTRAKFWHDWLAGVGGEFLNTWLLLSLVLLIAALFKSSGAAVAVGIIGYFVLGMVNIPMIALIRKYTWLKWNPLNMFNFSAQLGLPTLSKITNLTDVQLFWGNLAYIILFLVLGLLFFRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI3</accession>
    <name>F9UPI3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="13" type="ordered locus">lp_1850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889636.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1850"/>
    <dbReference type="EnsemblBacteria" id="CCC79122">
        <property type="protein sequence ID" value="CCC79122"/>
        <property type="gene ID" value="lp_1850"/>
    </dbReference>
    <dbReference type="GeneID" id="57025430"/>
    <dbReference type="GeneID" id="66449683"/>
    <dbReference type="KEGG" id="lpl:lp_1850"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1559"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_9"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="PhylomeDB" id="F9UPI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1585-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="715" mass="80716" checksum="51B625D2951249CB" modified="2011-10-19" version="1">MAASTTKAKPAAKRKTATKTATKRKSKTPAKKLVIVESPSKAKTIEKYLGRSYKVVASLGHIRDLPKSKMGVDVDNDYEPHYISIRGKGDVIKGLRKEAKKAKAVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDTVKNAFKEPRSIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALDLIIQRENEIKAFKPQEYWTIDSEFQKGRSKFMASFYGTHGKKQPLDDNDAVQKILGQLDRNGDFNVVKVVKKERKRFPAPPFTTSTMQQDANRKLNFRTRKTMMAAQQLYEGINVGGKEGSVGLITYMRTDSTRISSIAKHEASQFLHKEYGAEYAATKPVKGKLPEGAQDAHEAIRPSSVFRTPASIKDYLTKDQFRLYQLIWSRFVASQMTPEVLDTMAVTIDQNDVQFRANGSKTKFAGFTKIYDKTEKNNVLPDLSEGDVVKLSKTDPQQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLEARRFVPTELGEIVNDIIQEYFPDVVNVGFTASLEEQLDATEEGKENWVKVVDSFYKPFSKEVATAEESMEKIQIKDELAGFNCDICGAPMVVKMGRYGKFFACSRFPDCRNTKPIVKEIGVVCPQCKKGQVIERKSKKNRIFYGCSRFPDCDFVSWDKPVGRDCPKDGHYLVEKKVKGGKQVLCPNGDYTENVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ7</accession>
    <name>F9UPJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular lipase/acylhydrolase with GDSL-like motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101576.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1867"/>
    <dbReference type="DNASU" id="1064180"/>
    <dbReference type="EnsemblBacteria" id="CCC79136">
        <property type="protein sequence ID" value="CCC79136"/>
        <property type="gene ID" value="lp_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1867"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1573"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076859_1_0_9"/>
    <dbReference type="OMA" id="VSMYNPF"/>
    <dbReference type="PhylomeDB" id="F9UPJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1598-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="61"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="34475" checksum="61FFBEB8FD4324F1" modified="2011-10-19" version="1">MSKVKETIKIILVVAVLAVGVFFGVNYLLHPQNESVTTTPTTTKKTTAKKTPHKAKINLVAVGDSLTEGVGDESEGGYVGQIKKTLTTKQKLKVTTTNAGKSGDRSDQILARINKSKVLQQKIAKADVITVTVGGNDLLQTLEGSLTSNNTAKNNATVAKAQTLYANKLTKLFNKLQSLNGTASVFVFSIYNPIYVNFPNVTSITHYISQWNDQTQTTVSQYKHTYFMDINWTMSHGQYKTAAQIRKLKKAASATTLTSLTSSKAITGALEAENKTNDLISTADNFHPNKRGYRVFTTKLYQTMMAHDAWLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ8</accession>
    <name>F9UPJ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889651.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1868"/>
    <dbReference type="EnsemblBacteria" id="CCC79137">
        <property type="protein sequence ID" value="CCC79137"/>
        <property type="gene ID" value="lp_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1868"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1574"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_2_9"/>
    <dbReference type="OMA" id="EIHAKIN"/>
    <dbReference type="PhylomeDB" id="F9UPJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1599-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="30163" checksum="5902CF660E8352CA" modified="2011-10-19" version="1">MTKIKIVTDSSANLTDAEVKKYDITVIPLTVMIDGTIYVEDETITREEFIDKMATAKSLPKTSQPALGTFIETFDKLGADGASVICINMLEAISGTVHTAEQAASITKTDVTVIDARTTDRAMAFQVLTAAKLAQSGADKQAVIDQIHATQAHTKLFMGVMTLNNLVAGGRISRLTGAISTLLNVKIALEVDDGTLDVKMKGRGVKAINKFFDKVLDDIIATPNVAEVAISHVGATERVEEYRARLQAALPSLKISVQPTVPIIATHGGPGAFAVEYHTQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ1</accession>
    <name>F9UPQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, atypical SDR family, subgroup 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889704.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1930"/>
    <dbReference type="DNASU" id="1062132"/>
    <dbReference type="EnsemblBacteria" id="CCC79190">
        <property type="protein sequence ID" value="CCC79190"/>
        <property type="gene ID" value="lp_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1930"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1627"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308838_0_0_9"/>
    <dbReference type="OMA" id="PQRELMI"/>
    <dbReference type="PhylomeDB" id="F9UPQ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1652-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="210" mass="23389" checksum="F808D3AF58A21FCB" modified="2011-10-19" version="1">MNILIIGTGKLGYEVYRRVAVMPQHHVTLLDHHRHEHDVLLATQLIGDASNVDDLKRALRGIDVVFSTVGITHAAQFATALVQAMDAVGVTRLFWTTQFQINYDQISEAMYTLAHREFGFSREVETTYVAGQKAGAAVIRNSDLDYTLLACHFFKYNDEADQLIVEPAGNAVSGGPLSLFSLATLITDMLEHPQDYPQRELMISTRPGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ72</accession>
    <name>F9UQ72_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed DNA polymerase III, delta chain</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ordered locus">lp_2128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889875.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2128"/>
    <dbReference type="EnsemblBacteria" id="CCC79361">
        <property type="protein sequence ID" value="CCC79361"/>
        <property type="gene ID" value="lp_2128"/>
    </dbReference>
    <dbReference type="GeneID" id="57025667"/>
    <dbReference type="KEGG" id="lpl:lp_2128"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1802"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_4_0_9"/>
    <dbReference type="OMA" id="EEPYYID"/>
    <dbReference type="PhylomeDB" id="F9UQ72"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1822-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="39737" checksum="078E1AE33379A28B" modified="2011-10-19" version="1">MIAINAQQALKSIRNGDLASIYVILGTVDYLADQLKQAFTQQIPSEEQTMNVGSYDMETTPVAVALDDAMSAPFFGERRLVFINHPYFLTGENKKTKVDHDLASLQHYFEQPEPSTILVFMAPYEKLDARKKLVKTLKKQATTVEVNQVSEAETQRYVQAALDEKQIRIDADALQELVNRTDGQLGLIMGQLPKLMIYAAQSQRIDLAAVQALVTKSLTQNVFDLVNDVLRYQTQSAVELYHELVAAQEAPLKINAILLGQFRLLLQVKIMARAGYSQGSLASTLKVHPYRVKLAMQTVRHFDQAALRAAYLGLLQTEVQMKTTQRDPELLFELFMVQFVNERQSAVGTRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA0</accession>
    <name>F9UQA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular protein, NlpC/P60 family,gamma-D-glutamate-meso-diaminopimelate muropeptidase</fullName>
            <ecNumber evidence="8">3.4.19.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.11" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889903.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2162"/>
    <dbReference type="EnsemblBacteria" id="CCC79389">
        <property type="protein sequence ID" value="CCC79389"/>
        <property type="gene ID" value="lp_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2162"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1830"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_1_0_9"/>
    <dbReference type="OMA" id="RMITEAK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1850-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388094" evidence="5">
        <location>
            <begin position="31"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="7">
        <location>
            <begin position="375"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="496" mass="48338" checksum="5E5DE5BA876AC21B" modified="2011-10-19" version="1">MSQAHTTGKVLASTVGAVGLLLATGQAANAASITVKANDTVWGLAQQHGVSVQSIEKLNQIKASDGNIDLIYVGQNLQIGGSATKTATTKSATKKAATKGTYTVKAGDTLWALADKYNTSVHALQTLNGLSGDLIVVGQNIQVPGATTKTTAKTSQKTTMSATSAASTTSTTAKATTAVSASSTSSTSASSVSSVSASVVSSTSAASQDAVSANSASSTSTSTISSSTGSVASSTATTSNAPVKAVATSAAVSASNASSSTATSQSKSVAASASVTSSASSSAASSTTTSQSTASTASATSTSSTTATSTASQASSTAASAASTTSTASQSSSAATSSSTTSQSSSSAATSSASNTASSTATTNSSSTTTSSTSDLATGSVTGLALKLASANIPYVWGGASLSGMDCSGLVSYVYQHAAGITLPHSTVAQESYVTTHSVADAQPGDILFWGSRGSTYHDAIYIGNNQYVAAPTEGQNVQVQTISSYFMPSFAGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG7</accession>
    <name>F9UQG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial type II secretion/trafficking system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for transformation and DNA binding.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644627.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889970.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2244"/>
    <dbReference type="EnsemblBacteria" id="CCC79456">
        <property type="protein sequence ID" value="CCC79456"/>
        <property type="gene ID" value="lp_2244"/>
    </dbReference>
    <dbReference type="GeneID" id="57025792"/>
    <dbReference type="KEGG" id="lpl:lp_2244"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1898"/>
    <dbReference type="eggNOG" id="ENOG5030A0S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633316_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1941-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0178">Competence</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="22252" checksum="FEC3E8C74FF38A47" modified="2011-10-19" version="1">MNARPCRRFRRPENNMKTGNVSSYYPGYRSKHMIRRRGFTLIEAVVSLAIVAVVLTTLFQGQRNLARRTQVDLPTVDWYLMLHELENPDHHFVVDHISDEGGLTPGKAVHLVNTVTGKQYLLTYYHILHRIGLRHYGGGEINLMQGVRQFHVADDLTLTMTTDKGIHFQAQLLLPDRRTMVDEEATRNDPAFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ0</accession>
    <name>F9UQQ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645413.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2347"/>
    <dbReference type="DNASU" id="1062359"/>
    <dbReference type="EnsemblBacteria" id="CCC79539">
        <property type="protein sequence ID" value="CCC79539"/>
        <property type="gene ID" value="lp_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2347"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1984"/>
    <dbReference type="eggNOG" id="ENOG5030DU7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074786_0_0_9"/>
    <dbReference type="OMA" id="GWAHAFT"/>
    <dbReference type="PhylomeDB" id="F9UQQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2023-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021247">
        <property type="entry name" value="DUF2785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10978">
        <property type="entry name" value="DUF2785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="36828" checksum="D4763E9951F6F97C" modified="2011-10-19" version="1">MQAEKLMQVKDAVLKLRQQLRAGQIYQSLPSRMATLIKQLPSTVTTTVTIPSDEEVLPLIATLHEQLKKGTLTAMSDDQIKLLMAHVGSLNPLVRDQGVYYLLNEALQQQVLTPEQLGDIFDQLIQDQMLFAHIDEPQNDAIYQRSFAILLLSVLLYADHAGLKFMTPARLDLVVEQMTVYILLEKDTRGFVGTTGWAHAYTHIGNILDELADESQLARADKLLLLAALIARYQKLTTPLIFGEPERLSTYLTLITNKHELYCDYLLTAMKDWHQQLMMHTRPASEAEWTQIFNRNRLLEALALHDDLPTAVVDYLDDELEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQR0</accession>
    <name>F9UQR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein serine-acetylating enzyme</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641446.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890063.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2360"/>
    <dbReference type="EnsemblBacteria" id="CCC79549">
        <property type="protein sequence ID" value="CCC79549"/>
        <property type="gene ID" value="lp_2360"/>
    </dbReference>
    <dbReference type="GeneID" id="57025893"/>
    <dbReference type="KEGG" id="lpl:lp_2360"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1994"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_9"/>
    <dbReference type="OMA" id="QHLGIMT"/>
    <dbReference type="PhylomeDB" id="F9UQR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2033-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20991" checksum="A5A4EDB8606206DE" modified="2011-10-19" version="1">MFINIIDKHISLKPTEVADAEPLFDLVDHNRDHLKLWMPWVDATATVQDERHFIESMLTKQAHGQVFITTIIVDGEVAGMLDLHNISAINHNGEIGYWLGQKYTGRGVMTKALERLEEIAFTELDLHKVILGADVANQASRAVAERRQYHLDATLPENILLNGQYRDEAIYSLTVDEWSKRQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQV2</accession>
    <name>F9UQV2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101744.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2412"/>
    <dbReference type="DNASU" id="1062468"/>
    <dbReference type="EnsemblBacteria" id="CCC79591">
        <property type="protein sequence ID" value="CCC79591"/>
        <property type="gene ID" value="lp_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2412"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2038"/>
    <dbReference type="eggNOG" id="ENOG5030A38">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452738_0_0_9"/>
    <dbReference type="OMA" id="MDFNEAT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2076-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="20119" checksum="0518AB0C633A5B95" modified="2011-10-19" version="1">MAGLKLQTKSADKILYGIKFPWDDKATLIQMLGLQAATSTTNTRASSAVNLKQGVLHTSGSRSQTFVVDSYWTIGDKIHDGLKKAVQQDVAVGIWRMDFNEATLDTAGKVKTVPAEFGMAKPNGLPETEAVNNLLHANITYNIDGNTQDGVLDVAELDPQLLADGLKMFDFAHNTDVGSASVSSGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ3</accession>
    <name>F9UQZ3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101784.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2454"/>
    <dbReference type="REBASE" id="7098">
        <property type="entry name" value="M.LplWORF2454P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79632">
        <property type="protein sequence ID" value="CCC79632"/>
        <property type="gene ID" value="lp_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2454"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2071"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_4_0_9"/>
    <dbReference type="OMA" id="DPPYYVK"/>
    <dbReference type="PhylomeDB" id="F9UQZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2122-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="34972" checksum="30F85C150C865FA7" modified="2011-10-19" version="1">MPQTSSVFRYPGGKTQLYSFVHHLLKINSITDISLEPFAGGAGIPLKLLIDNRINTVWINDYDKAIYSVWDTILNDPVALISLIESVPFDYHSGHKISPEFSISFWKKQKDIYLNNKNHQHSIELAFSTLFLNRTNTSGIITAGPLGGFKQNRKTQIYARFNKETLINKINLIHSFKSQIKLTRLNTLDMIPKIRNSVDPKNSFIFFDPPYFEQGKELYYSSFNEQGHKELANGILSLKQYHWITTYDTAPQIQEDYTMAKQKYEYSLNYSANNKNRGKTAEFMFASPVTRLSSFEKVDLTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR05</accession>
    <name>F9UR05_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101795.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890158.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2471"/>
    <dbReference type="EnsemblBacteria" id="CCC79644">
        <property type="protein sequence ID" value="CCC79644"/>
        <property type="gene ID" value="lp_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2471"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2082"/>
    <dbReference type="eggNOG" id="ENOG5030BF5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2880282_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2136-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="63" mass="7263" checksum="1BAD5F36561CF6A3" modified="2011-10-19" version="1">MKIKMVHADNMEELFAQVSEVSKAQDIDDELIDNGFDFIKVSDSKMIYCEALVYRTGDEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR61</accession>
    <name>F9UR61_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101821.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2541"/>
    <dbReference type="EnsemblBacteria" id="CCC79700">
        <property type="protein sequence ID" value="CCC79700"/>
        <property type="gene ID" value="lp_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2541"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2136"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_0_0_9"/>
    <dbReference type="OMA" id="GAKLVKH"/>
    <dbReference type="PhylomeDB" id="F9UR61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2192-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394303" evidence="1">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="332" mass="35023" checksum="53C28648BDAC83CB" modified="2011-10-19" version="1">MIAFISALIVFLGVAFVMTGKTTATKTTSTKKVPTVGILQLQTHPALDAIHRGVVAGLKEYGYVDGKTVKIDYQNAQGDQSNLKTMSQKFMNENAALTVGIATPAAQALASAANKQTPVMLAGITDPSGSGLIKSDQHPGANITGTSGESPLKSHLDLLRKLVPSAKTIGIIYTTSDHGGEYNAKKFARICKQEGMKYKLYTISNTNDMQQVAETMAANVDAVYAPQDNGVASAMKTLVSVTNKAKVPVIPAVDTMVKAGGLATLSVDQYQLGKLTGEMAAQVLKGKATSDYPIKVITKGKMTINLSEAKKLGIKFPASVLKEAKAKGVIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR62</accession>
    <name>F9UR62_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642727.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2542"/>
    <dbReference type="EnsemblBacteria" id="CCC79701">
        <property type="protein sequence ID" value="CCC79701"/>
        <property type="gene ID" value="lp_2542"/>
    </dbReference>
    <dbReference type="GeneID" id="57025965"/>
    <dbReference type="GeneID" id="66450252"/>
    <dbReference type="KEGG" id="lpl:lp_2542"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2137"/>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067296_0_0_9"/>
    <dbReference type="OMA" id="RHILIHA"/>
    <dbReference type="PhylomeDB" id="F9UR62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2193-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="32018" checksum="630199FE6DF91439" modified="2011-10-19" version="1">MSMIVSSIGQGLLWATLGVALFLTFRILDFPDMTVEGTFPLGAATAVMAISHGMGPVTASLLAFVAGAITGLVTGLLYTKGKVPILLAGILVMTACLSINLRIMGGSSNVSLLGKQTIFSNHFLESLPKYFDSVFVGLVVISIITVLLIVFLQTNLGQAFIVTGDNREMARSIGINTDNMTIMGLMVSNGIIGLGGALIAQNNGYADVSMGIGIIVIALASIIIGEVVFGELTLNQRLVAVTLGSILYQFVRLLVLQLGFNTNDMNLLSALILAICLMLPQFSKVLHLNHVLKKGVARYDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB4</accession>
    <name>F9URB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP2</name>
        <name evidence="8" type="ordered locus">lp_2608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101852.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2608"/>
    <dbReference type="EnsemblBacteria" id="CCC79753">
        <property type="protein sequence ID" value="CCC79753"/>
        <property type="gene ID" value="lp_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2608"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2190"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_6_4_9"/>
    <dbReference type="OMA" id="DDHETMS"/>
    <dbReference type="PhylomeDB" id="F9URB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2244-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="667" mass="74242" checksum="1B2AE6C57F0BCE31" modified="2011-10-19" version="1">MQTVFLVLLLVAAVVVANAVYARFNQIPVAFLQIGAGLILSLIPLYRNFELEPEIFLFVIISILMFNDGQNTNIRKLSHQFGTTLSLSVVLAIVTILIVGTVTHLLIPEFSLALAFALGAIITPTDAVAVSSITTKVAIPGEVMTTLENESLFNDASGIVAFNLAIAAIVTGKFSVWHGVTNFLYVFAGGIFVGLIIGYIIVAVRIMLIRMRVDTPSVIVPYTLLTPFVVYFLAESLGVSGILAVVATGLIHGVQSDQLRLTTSRLQIVMTTTWSIVASILNGIVFVLLGVSLPSVINHLQQRDTSSVAVLVGLGILLYLIMTFARFLWTRFDLARIRAWDNHEKTRNAFVMGLSGVHGTITLAMAFSLPLTLNGSAFPYRNDIIFVAAVVILTSLMVPTLLLPLTLPKQVVKVTEDELATAKADMVTHAIDLMQARHGNNAGTSKVIAILSGQRVLDGRPKRSQLASLFDATFKVEQTTIDEMVANNEITPQAAEKYMRVASQTRLQNQQTFFERLKLFFRFTLSKWSLSKKARARRKMFRQYRPHGGQSRAELMTRNRQMWQQMRQIEQKPYEAVLAYLADTITADNQQAIGIVRRAYDERHRRLSGERDFQETQNELLIEAFQLEYNFIQTQLANKTFSSELGNQLYEQISTDQLVYLQSINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF4</accession>
    <name>F9URF4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-04" db="PDB data bank">
            <title>Crystal structure of Q88U62_LACPL from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Benach J."/>
                <person name="Su M."/>
                <person name="Seetharaman J."/>
                <person name="Forouhar F."/>
                <person name="Chen C.X."/>
                <person name="Cunningham K."/>
                <person name="Ma L.-C."/>
                <person name="Owens L."/>
                <person name="Baran M."/>
                <person name="Acton T.B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101874.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890307.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2PJQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/C/D=1-218"/>
    </dbReference>
    <dbReference type="PDBsum" id="2PJQ"/>
    <dbReference type="SMR" id="F9URF4"/>
    <dbReference type="STRING" id="220668.lp_2664"/>
    <dbReference type="DNASU" id="1062909"/>
    <dbReference type="EnsemblBacteria" id="CCC79793">
        <property type="protein sequence ID" value="CCC79793"/>
        <property type="gene ID" value="lp_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2664"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2232"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_2_2_9"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="PhylomeDB" id="F9URF4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2284-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2PJQ"/>
        </source>
    </evidence>
    <sequence length="218" mass="24330" checksum="BA8C78AA9D639D61" modified="2011-10-19" version="1">MITETQLTAIQTYALQKLAHDHSGHGRDHLQRVNRLARRLAKDEGANLNLTLAAAWLHDVIDDKLMANPAKAHQDLIVQLNAQNVTADDQTAIFAIIDHMSFSKSFNGPQKLSLEGQVVQDADRLDAIGAIGIARALYYSGHVGEKIYDPAIAPREHMTREQYRHQPGTAINHFYEKLFKLAALMNTDTAKALAAHRTAVMHEFVDQFKAEWTADDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK9</accession>
    <name>F9URK9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptp3</name>
        <name evidence="1" type="ordered locus">lp_2735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890362.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2735"/>
    <dbReference type="DNASU" id="1063035"/>
    <dbReference type="EnsemblBacteria" id="CCC79848">
        <property type="protein sequence ID" value="CCC79848"/>
        <property type="gene ID" value="lp_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2735"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2288"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_0_2_9"/>
    <dbReference type="OMA" id="YIFRSGM"/>
    <dbReference type="PhylomeDB" id="F9URK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2339-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="30027" checksum="99FBF0C664B218EB" modified="2011-10-19" version="1">MVSKMTNQRVLTVPGGINFRELGGYSTKDGRKIKWHKVIRTGGLDQLTPTGQALLDDYGVRYDIDFRSPQEVLDAPDRIPANAKYVYAPVFNVDETRNSDGTDKMTANLEKHPDSGFKHMLKVYQMVADEQHAKDEYRRFFDNLLANDQPDSTLLFHCTAGKDRTGMGAVYLLTALGVDFETIKQDYLLTNQASIGRINGAMAEARAQGASDATVESIRALWSVDADYLDAAMTEIKRQSGNLNHYLHTELKLTNNEINDLQRIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL0</accession>
    <name>F9URL0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cah</name>
        <name evidence="3" type="ordered locus">lp_2736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890363.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2736"/>
    <dbReference type="EnsemblBacteria" id="CCC79849">
        <property type="protein sequence ID" value="CCC79849"/>
        <property type="gene ID" value="lp_2736"/>
    </dbReference>
    <dbReference type="GeneID" id="57026109"/>
    <dbReference type="KEGG" id="lpl:lp_2736"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2289"/>
    <dbReference type="eggNOG" id="COG3338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_0_2_9"/>
    <dbReference type="OMA" id="ERFHFHD"/>
    <dbReference type="PhylomeDB" id="F9URL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2340-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="23399" checksum="54363E973651F2F4" modified="2011-10-19" version="1">MTFDYAHQTDWPMTSGQHQSPIDIQTQHVQSSQLSAINWRGLYQAKTITGEATTLKASGIGAAYLNDRDFAFQQIHFHTPAEHLIDGQAAPIEWHLVHQSATGQLAVVAVFGRIGKPNSSLQGLLDQFTAQTSHELTTPVNLTELLPDTGTVYHYLGSLTTPPLSETVEWYVCADTVMIGEQQLAAYQQLFAANNRKIQPLNDRPIIAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM1</accession>
    <name>F9URM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Teichoic acid glycosylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gtcA2</name>
        <name evidence="8" type="ordered locus">lp_2747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642569.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890374.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2747"/>
    <dbReference type="EnsemblBacteria" id="CCC79860">
        <property type="protein sequence ID" value="CCC79860"/>
        <property type="gene ID" value="lp_2747"/>
    </dbReference>
    <dbReference type="GeneID" id="57026120"/>
    <dbReference type="KEGG" id="lpl:lp_2747"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2300"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_1_1_9"/>
    <dbReference type="OMA" id="FFTNDIF"/>
    <dbReference type="PhylomeDB" id="F9URM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2351-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="138" mass="16194" checksum="2A62E15115F3059A" modified="2011-10-19" version="1">MGQLIKQLWQRYQSVLSYLIFGGLTTLINIIVFGIFNQFWPYWIANTIAWLISVLFAYITNKIWVFDSQTPTFRAVLIEMTSFFGFRLLSYFIDQGIMIVGISVLHGNDLIVKLIDQIIVVLLNWFFSKLFIFKDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM5</accession>
    <name>F9URM5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890378.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2753"/>
    <dbReference type="EnsemblBacteria" id="CCC79864">
        <property type="protein sequence ID" value="CCC79864"/>
        <property type="gene ID" value="lp_2753"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2753"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2304"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568769_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2355-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="167" mass="18216" checksum="B27B3C590A8C82EE" modified="2011-10-19" version="1">MMINEPAISPLFVCGIIGDSTAMVLNKSLTGPFKNRYDLVTAPVTTRATLSEAVSQIAQLQTGLQTVISKQLGTVQLTIPALTTLELPATLINIYYLLEPVGGHLLLKRPHYTESMSAGAARVPLDQLNWSNSSPRVMQAKRFLQTGAFPTADQRIDGYQVLEQAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP6</accession>
    <name>F9URP6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
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    </protein>
    <gene>
        <name evidence="3" type="primary">pbg4</name>
        <name evidence="3" type="ordered locus">lp_2777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642544.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890399.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URP6"/>
    <dbReference type="STRING" id="220668.lp_2777"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79885">
        <property type="protein sequence ID" value="CCC79885"/>
        <property type="gene ID" value="lp_2777"/>
    </dbReference>
    <dbReference type="GeneID" id="66450423"/>
    <dbReference type="KEGG" id="lpl:lp_2777"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2325"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="IPGKNYP"/>
    <dbReference type="PhylomeDB" id="F9URP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2376-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="480" mass="54711" checksum="71B43320B0A25384" modified="2011-10-19" version="1">MATTSGLRSDFLWGGAVAAHQLEGGWQAGGKGVSVADVMTAGANGVPREITDGVIAGKNYPNHEGIDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPNGDEEEPNEAGLKFYDDMFDTCRQYGIEPVITLAHFEMPYHLVKEYGGWRSRKVIDFFVHYAETVFKRYKNKVKYWMTFNEINNQTTYTNQFLMATDSGLVLKPDDPDAEALMYQAAHYEVVASALAVKIGHAINPDFQIGNMINMTPIYPATAKPQDIMQAEKAMQRRYWFADVQSWGYYPNNMEAYFKQTGFRPDITAEDRQVLKEGTVDYIGFSYYNSNTVAAQDDNPSYHFVGTEAVDNPYLKTSEWDWPIDPEGLRYSLNWLQDRYHKPMMIVENGLGARDKVEADGSIHDPYRIDYLRAHISEMIKAVTEDGVDLIGYTPWGCIDLVSAGTGQMSKRYGFIYVDKDDEGNGTLERSKKDSFYWYQKVIRTNGADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT6</accession>
    <name>F9URT6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar specific permease, N-terminally truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79925">
        <property type="protein sequence ID" value="CCC79925"/>
        <property type="gene ID" value="lp_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2828"/>
    <dbReference type="eggNOG" id="COG2364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110210_0_0_9"/>
    <dbReference type="OMA" id="ARANLIM"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="18658" checksum="C1081726671A6D4F" modified="2011-10-19" version="1">MVVTILNQLLLGHFDRRRFISNLLYIVPFSYLVQFIGYFWDWLQIPALPLLPRLILNVLGLLGVAAAVSIYQRCNLIQHPNDDLSYILRFRFLHGSAIIAQWTSYLPPLTIIVVSFFATGHLRAIGFGTVFALIAQGAIMGWSDHHVFPHLKHHVDIVQAHHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW9</accession>
    <name>F9URW9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgm8</name>
        <name evidence="1" type="ordered locus">lp_2868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890472.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2868"/>
    <dbReference type="EnsemblBacteria" id="CCC79958">
        <property type="protein sequence ID" value="CCC79958"/>
        <property type="gene ID" value="lp_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2868"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2401"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="IVYQDGT"/>
    <dbReference type="PhylomeDB" id="F9URW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2455-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="22899" checksum="E61B324D5BEEF47B" modified="2011-10-19" version="1">MKSITLHLVVAGATYFNQLDRFQGWSGTPLTATGEQATAKVAQQLASTTFDTAFASDTSRAIQTARIILDSRAQPVKLRTVVALRAPFYGGFEGTERAAVWSGFATKLGYQSVAAFAADQTPSELQTLLHDHDADGLAESGQEFWDRYQKGLQQVMAATPDHGQVLLIVDGATLRMMHYVATGRAATRQELAPSVVTTMVYTGDKLTVPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9US05</accession>
    <name>F9US05_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ropB</name>
        <name evidence="2" type="ordered locus">lp_2918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101970.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2918"/>
    <dbReference type="DNASU" id="1063337"/>
    <dbReference type="EnsemblBacteria" id="CCC79994">
        <property type="protein sequence ID" value="CCC79994"/>
        <property type="gene ID" value="lp_2918"/>
    </dbReference>
    <dbReference type="GeneID" id="66450530"/>
    <dbReference type="KEGG" id="lpl:lp_2918"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2436"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926831_0_0_9"/>
    <dbReference type="OMA" id="RMAANCA"/>
    <dbReference type="PhylomeDB" id="F9US05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2490-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="303" mass="34719" checksum="0B1A636CF99B32F5" modified="2011-10-19" version="1">MTNIGETIHQIRLSKGLTQQEVYSGIISRSFASRFESGANDIGASKLFAILDNLAISADELRFIHQNYQPSAYDQALWTIRHAYETLNFPALATWIREHRHSPHAYEQLIASYASILMLSYDHRSIGITTTTQPAFDHLRQAKTWTLQELKLVPVLIPIIASIDGLAALTPLTTRMAANCASYQTAWGDPFHVSNDLLDFYGSLFQTKLNFHDFQSAQNLKTKFTAIDSHQLNWDGRLSQQFWLGIWNLYFGDWQIGNQLLDEVSVLETHHHPRIDNTLFAIRNVRTKQAQTYRQSHQSHKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9US07</accession>
    <name>F9US07_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proline-containing amino acid or peptide transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890510.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2920"/>
    <dbReference type="EnsemblBacteria" id="CCC79996">
        <property type="protein sequence ID" value="CCC79996"/>
        <property type="gene ID" value="lp_2920"/>
    </dbReference>
    <dbReference type="GeneID" id="66450532"/>
    <dbReference type="KEGG" id="lpl:lp_2920"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2438"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_6_1_9"/>
    <dbReference type="OMA" id="SRWVWTA"/>
    <dbReference type="PhylomeDB" id="F9US07"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2492-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="455" mass="49674" checksum="492748201FFF1E0B" modified="2011-10-19" version="1">MDLKHTPSSSNTNLDEFGYQQELKRTLSVKDLVIYGLIFMVPIAPMGIYGAVISVSQGMIALTYAIGMLAMFFTALSYGQMSQAFPVAGSVYAYAKLGINKSIGFLSGWMIILDYIFVPALLYIIAANSLKSLLPTIPTWLWLVGFIAINTLINVGGIAFTAIANRIFLIGELIVLAFFIILGSYGLMRGIGNGFTLKPFYDASHFNLNFVMTATSVAVLSFLGFDGISTLAEETTGGNQAVGKGILWSLLIVGALFIIQTYLAALIVPNWHSFNDLNTAFYVVAGKVGGPFLTDLTTIATILSWGFANALAAQAAISRILFGMARDHNLPHVLARVHPRFKTPYMSTLLVAIISLLVGLTFMNDSGTLSEIVNCGALTAFLVIHIAVINHFFIKQHSHDYWHHLIVPIIGFIIIGFVMINLNVLAKEIGGIWLLIGIGYYLILRVLQRNTEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9US19</accession>
    <name>F9US19_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
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        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890522.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80008">
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        <property type="gene ID" value="lp_2934"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2934"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2450"/>
    <dbReference type="eggNOG" id="ENOG5030A5S">
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    <dbReference type="HOGENOM" id="CLU_1747322_0_0_9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388981" evidence="1">
        <location>
            <begin position="23"/>
            <end position="157"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80008.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="157" mass="17311" checksum="DF83330BE49F6B8B" modified="2011-10-19" version="1">MQKSRGIIVGLLLTGLLTGCHSATDTQTPTVQPATSKVSAVRSVTTRDFLGRWVSARPAMSLYLSTNHQVAWFRRGHTPIRSRATLTLSDTRATFTIDHNVAKLTLNDANQMTMNYQGTNIALIKDPNWQPEHNQVPTTTNDALKAGTLTPTFKLSY</sequence>
</entry>
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        <name evidence="5" type="primary">pgmB2</name>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="KEGG" id="lpl:lp_0066"/>
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    <dbReference type="PhylomeDB" id="F9US84"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="PGP-like_dom2"/>
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    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HADHALOGNASE"/>
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    </dbReference>
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        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
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    <feature type="region of interest" description="Substrate binding" evidence="2">
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    <feature type="region of interest" description="Substrate binding" evidence="2">
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    <feature type="active site" description="Nucleophile" evidence="1">
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            <position position="13"/>
        </location>
    </feature>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="3">
        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
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    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
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        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
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            <position position="151"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR610972-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-4"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77631.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="3">Acetoin utilization protein, N-terminal</fullName>
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        <name evidence="3" type="ordered locus">lp_2980</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2980"/>
    <dbReference type="EnsemblBacteria" id="CCC80042">
        <property type="protein sequence ID" value="CCC80042"/>
        <property type="gene ID" value="lp_2980"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2980"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2683255_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USB2"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8192" checksum="627A34ADB9B114EF" modified="2011-10-19" version="1">MSVADYMTPRLVVVSPKTTISVAVELMKKNAIHRLPVMAGNRMVGLITHGIIQRAMPSQATSLSVYELNYLLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC9</accession>
    <name>F9USC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">lp_3000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101999.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3000"/>
    <dbReference type="EnsemblBacteria" id="CCC80059">
        <property type="protein sequence ID" value="CCC80059"/>
        <property type="gene ID" value="lp_3000"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3000"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2504"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_78_2_9"/>
    <dbReference type="OMA" id="VVILITH"/>
    <dbReference type="PhylomeDB" id="F9USC9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2553-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="666" mass="72603" checksum="F54A50FC28CADB70" modified="2011-10-19" version="1">MSYLELKDIHKAYYLGKEAFPVLNGINLTFERGEFVAILGESGGGKSTLMNIIGGLDRQFQGQVLLQGTALDHHQEKQMDQYRRETVGYIYQSYNLINHLSVLDNVLISLDMTKLNRSEREQRAKQLLTQVGLADQIKKYPNQLSGGQKQRVAIARALASDPQIIIADEPTGALDSENTTEVLKILDQIAAEGRLVICVTHSQDVANAGTRIVRLADGKITDDERVKPAYPVDENRQQIAARKLPWYVPLNTAFKHLRYTWTWNLIIIIGTAIGLFAVMLFNGLGNGLKGYINQEINDMVNPRVVTVSRYQKSSQSQRGGSQEGNQQAAAMGASVATTNQPTFSKAQLSKLKKVAHVQTVQPILSASNATITVGNKDYTASSLTTWTASNRKSIIKAGHVAGKNEIVVDKSSVAKKWSSKNWKQLVGKKVTVAFQTTNKSGKSVTVKRQLTVAGITDSTTGSGVNAVTYATMKDMRSAKNLSTQPTSVAVKVDSREHNDAVTKQINKLKIDGKRVYRATSIASMLDTVNTYVNLATTILAAIAGISLLVSALMIIVTMFMSVSARKKEIGILRALGESRRDIRRLFTSESLIIGVISALLATGIAYGIGAALNKVLYQIASYNMIEIQVSNIISTFIIALVIALLAAILPAWRAARLNPIDALAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH4</accession>
    <name>F9USH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-alcohol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.90" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642307.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890618.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USH4"/>
    <dbReference type="STRING" id="220668.lp_3054"/>
    <dbReference type="EnsemblBacteria" id="CCC80104">
        <property type="protein sequence ID" value="CCC80104"/>
        <property type="gene ID" value="lp_3054"/>
    </dbReference>
    <dbReference type="GeneID" id="57026373"/>
    <dbReference type="KEGG" id="lpl:lp_3054"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2551"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_9"/>
    <dbReference type="OMA" id="RVKMIAT"/>
    <dbReference type="PhylomeDB" id="F9USH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2597-MON"/>
    <dbReference type="SABIO-RK" id="F9USH4"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018456">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="40018" checksum="C57111DEB6E7F516" modified="2011-10-19" version="1">MKIKAAVVDKVNDPFVIKDDIELAEMKATDLQIKMVATGICHSDEAIRRGDASLGYPVILGHEGSGIVEKVGSEVTNFEVGDHVILSFYADGTCDNCLKGMPTKCRNYADYNLSGTRPDGSDHFQENGHHISDMFDQSSFTTHTVVDQRNAVKVPKELDLRRLGPLGCGYVTGSGTVLNSLQPRPGQTIAVFGTGAVGLAAMMAGKISGCTEVIAVDIVDSRLELAKELGATHAINSKEEDPVEAIKKLTHGYGVDFAVDTTGVEPVMVSAIHALAQGGTAALIAVTAKNITISSWNDLCVDDKKVIGVNMGDAIPGVDIPRLIDFYQHGMFPFEKTEKFYKFEDINQANADSGSGKTIKPVLIIDEDYQPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN0</accession>
    <name>F9USN0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell surface protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3117"/>
    <dbReference type="EnsemblBacteria" id="CCC80160">
        <property type="protein sequence ID" value="CCC80160"/>
        <property type="gene ID" value="lp_3117"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3117"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2606"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318028_0_0_9"/>
    <dbReference type="OMA" id="FGSHTIS"/>
    <dbReference type="PhylomeDB" id="F9USN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2653-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394415" evidence="4">
        <location>
            <begin position="26"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="5">
        <location>
            <begin position="547"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="750" mass="80687" checksum="8E4B834088D931AE" modified="2011-10-19" version="1">MRRICKVLMVIISIILGSGAPLNMAIPPLLALAAPDTSSSSTMSSSAISKVTDTNVMAVSADVTSTTDTSDTSSSDSTSATSTTTGNDTTETADTAVESGTVGTVAWTIDDAGVLTLSGGSFADLTGKRSPWYDYASSITNIKITDEITVTTASNYGYLFASLANVATVTGLNKLSMSGVTSTQSIFYRDSKLTSVDFGQTDFSTVTTMESMFEGCSVLTKVNTTNWNVSHVKSFKRTFYMCGKLTMLDVSNWDVTQVTNLDSTFSGCSSLPELDVSRWNTANVTTLASTFYSCSSVKIINASGWDTARVTDMTATFMNCTLATELNVSGWDTAKVTSMSRMFFYCENVIQLDVSGWITSQVTSLGSMFQNCSKVVTLDVGTWDTSKVTDMSFLFGGCSSLTTLNLEKWDTGSVTTLYSTFYNCSGLTSLLVDTWDTSKVTNCFWTFGGCSSLTTLNLRSWDLQSATASYGNFFNGSKKLQHLTLGPNFTFHNDKTMYLPEPSKQLPYNGTWQRNNDDPTYTSAELMTNYDGATMAGTYNWVKTSGTVLVKYVDGDGVEIADEETSSGTSGDAYQTTAKTIDGYTLHATPTNATGTYDASTITVTYVYDGNLFFNSSPTMLDFGSHTISGTTETYAPTLDKTLAVQNNGQISSTWNLTAELDSSGFVGADTGKMLLATLYYQTDDGKMTLSPGVAVQVYSQTTTDHKSVDISEHWSSNLGLLLEVPNGAAMADTYQGTISWRLNNTVANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN3</accession>
    <name>F9USN3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP4</name>
        <name evidence="8" type="ordered locus">lp_3122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3122"/>
    <dbReference type="EnsemblBacteria" id="CCC80163">
        <property type="protein sequence ID" value="CCC80163"/>
        <property type="gene ID" value="lp_3122"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3122"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2610"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_6_4_9"/>
    <dbReference type="OMA" id="TPPFWAS"/>
    <dbReference type="PhylomeDB" id="F9USN3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2656-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="10"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="533" mass="59118" checksum="B8A1E8B61E64722D" modified="2011-10-19" version="1">MALLISTGVLVVAAMVSIVINRRWLPRLSVNYVSMFIGAGIAVIPFLNGLIEKFNSDIFIGLIVAPLLYFEGQNTRLNLVGRHVREIVSLTVGMVILCAVMAGLGTSLLAGVGLPLAFILAAISTPTDATATESVTMGRVLPQREQTSLKLESLFNDASGIILLNMAILWYINGYINYSQTLWDFVYAAGGGIAFGGLVSGLIVYIRQLMLRSKLNFINNTYNNGTPLKVIYLMTPFVLYFGAEALGVSGIIAVVFAGLVHNAEGERSALANPQLASDIYQLIGLLSDILNSVVFIVLGIMLLRTALDHSVSYNGSLIWIVIGVILYVANLLARYGYVRLIHHVPNREAWVFALGGIHGAVTFALAFTVAETQVKTTDFNLVLMSESLLIILSLLVPTIVFRWLLPKIKTDTDGAAKMAVIREQMIEAGVHDLWQMPISQEFKAAVTFDLRSQNGHTTVRQFISEWRRMVQHPEYTADEMRELMVIYRQVFQTERDYLQRQYDATHAISEDLFNRLYHEITMAEMVVLEYGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN5</accession>
    <name>F9USN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102052.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3124"/>
    <dbReference type="EnsemblBacteria" id="CCC80165">
        <property type="protein sequence ID" value="CCC80165"/>
        <property type="gene ID" value="lp_3124"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3124"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2612"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="CECYTAY"/>
    <dbReference type="PhylomeDB" id="F9USN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2658-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="34061" checksum="E259D0E1A9C14B9E" modified="2011-10-19" version="1">MDLDRLQTFLKVVQYGSFQQVAAREYRSQRTVSKQMTQLENELKVTLFDRGQNRIQLTPQGRLFWASAQDIVNNYTTALTELRQFNVPTDQILRVGYFSAFEQRLLLPALYDLKQQHSELQLVVRQGSNEHLAQQVADGSLDLALSINYGRPAVTPESQLTAVPIYHNQMVIGVSRLNPLSRLSQLPPSALATLPILYYSPESSTFLLESFLASAPFIQDYEQIRRVSSAEQMHLLVALNQALAFYPAGLVPTKHDEQVAYLPITDAAQQGYDIVALLKSNRSRPLIAKLVQRLKANAKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USW0</accession>
    <name>F9USW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Linoleic acid isomerase</fullName>
            <ecNumber evidence="1">5.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lai</name>
        <name evidence="1" type="ordered locus">lp_0139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641742.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888205.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USW0"/>
    <dbReference type="STRING" id="220668.lp_0139"/>
    <dbReference type="EnsemblBacteria" id="CCC77691">
        <property type="protein sequence ID" value="CCC77691"/>
        <property type="gene ID" value="lp_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="57026978"/>
    <dbReference type="GeneID" id="66448273"/>
    <dbReference type="KEGG" id="lpl:lp_0139"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.115"/>
    <dbReference type="eggNOG" id="COG4716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024043_2_1_9"/>
    <dbReference type="PhylomeDB" id="F9USW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-113-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050058">
        <property type="term" value="F:linoleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="564" mass="64232" checksum="70D0EC130AF83F8A" modified="2011-10-19" version="1">MVKSKAIMIGAGLSNMAAAVYLIQDGHWDGKDITFYGVDMHGANDGGATTDFTNEYWNKNHPMANTTGYVARGGRMLNYRTYVDLMDLLDRIPSVTEPGMTAAEDTRDFDAKHRTYDIARLMQGGKGIINAGKLGFNNKDRTLLTKLIMMPDSEETKLDNVSIAEYFKDDPHMFQTNFWYMWETTFAFRTQSSAQELRRYMHQMIYEFTQIEHLVGVNRTRYNQFESMILPLIKYLQGQGVTFIDNKIVKDWQFKDTPMQDEITVTGLVIEDAQTGETEEVEVDEDTAVIFTNGSITDSATMGDYNTPAPENMDYGVSASLWKKATERFYNLGTPDKFFNDRNASEWVSFTLTTKNHLFLNEIVRITTQEPGNALNSFLSTTPITPLNQKDVNMSIVVHHQPHFTTQQPNETVLWGYFLYPRRQGEFVNKPYIKMTGKEMAQELIGQLSKVDPGPGNIKDKEKEILDSIVNNIPVYMPYASALFNNRAKSDRPEVLPKHSTNLAFTGEFAEQPYQMIFTEQSAVRSGEIAAYHFAGVPMDNLVKTPRYDKDPKTLLKATKKMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT23</accession>
    <name>F9UT23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0218"/>
    <dbReference type="DNASU" id="1061410"/>
    <dbReference type="EnsemblBacteria" id="CCC77754">
        <property type="protein sequence ID" value="CCC77754"/>
        <property type="gene ID" value="lp_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0218"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.181"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_9"/>
    <dbReference type="OMA" id="CHCVSGP"/>
    <dbReference type="PhylomeDB" id="F9UT23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-176-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="253"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="468" mass="52469" checksum="46C16201AB4709F8" modified="2011-10-19" version="1">MASIALNNLTYTYPQASTPILDRVNLTLPRQSFILLTGPSGTGKSTLLKLIAGLLPLTPDDGTITFDGQALTASTANQRAQHVAMMFQNPNQQFAMDTVENELIFALENLQVPRDQIPARLLSALDFVGIRNLQSRLLNHLSGGEKQKVALAIIVAMDSDVILLDEPFASVDPTARAVLLDRLVELRNQHGKTIILADHDLSGYEQLVDQVVQIKDQHLQLIDRTTWSELFSAFTEQPQRSWSAPQRVERPCFQLDHVTLQAGDRQLLVPTTRQLLAQHNTLITGPNGSGKSTLFEALVRLHPYTGEIRYEGTPIDKLKRKRYARHVALLFQDAETQFLNITVAEELAQSKRYAYGDYFTADRIQTALVQLNLSGRDEQVIYTLSEGQKKKLQILLMLIMQSPVLLMDEPLKGLDLHSINALVALLQTTQAATKQTLIIISHQLTGLMPLIDYQLHFENHHLDWVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT65</accession>
    <name>F9UT65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDP-glycerol glycerophosphotransferase</fullName>
            <ecNumber evidence="6">2.7.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagF1</name>
        <name evidence="6" type="ordered locus">lp_0268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.12" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888310.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0268"/>
    <dbReference type="DNASU" id="1061182"/>
    <dbReference type="EnsemblBacteria" id="CCC77796">
        <property type="protein sequence ID" value="CCC77796"/>
        <property type="gene ID" value="lp_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0268"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.223"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029598_1_1_9"/>
    <dbReference type="OMA" id="NPRTDYY"/>
    <dbReference type="PhylomeDB" id="F9UT65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-218-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="402" mass="47068" checksum="3DF0BF97B61761BA" modified="2011-10-19" version="1">MALKDIISQVYRRLFNVIATVCPVRKHVVLFEAFNGKVPMDNPLYVYEALQTAHPDWKLVWSVKRQLVVEAQEKYPKLNIIPRFSAKWLLVAPVAEFWVLNARMPYWLKKNAKTTYIQTWHGTPLKRLGIDIPKVSMPGTDTSQYRQNFTAESKRWDYLIAPNQFSKDVFRRAFDFNNQFLDYGYPRNDRLVHQRQDYDAIAAIKKRIVGNKMGKVILYAPTWRDDFFIRKGMYKMNLPFSLAAVVKRLNKEDVLIIRPHYLVAESINIQGFEDNVKLCVDEDINDLYLISDLLITDYSSVMFDYAILNRPMLFYPYDLAHYQGDVRGFYFDYNKVPGPIVTNEQDFLAKLDQFLTNDGYPNETAKMMAFRTQFTEWEQGTASQRVVKLITSIDQNANNYTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT67</accession>
    <name>LPDB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin prenyltransferase LpdB</fullName>
            <ecNumber evidence="1">2.5.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gallate decarboxylase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lpdB</name>
        <name evidence="6" type="ordered locus">lp_0271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Appl. Environ. Microbiol." volume="79" first="4253" last="4263">
            <title>Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation.</title>
            <authorList>
                <person name="Jimenez N."/>
                <person name="Curiel J.A."/>
                <person name="Reveron I."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
            </authorList>
            <dbReference type="PubMed" id="23645198"/>
            <dbReference type="DOI" id="10.1128/AEM.00840-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in tannin degradation. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for gallate decarboxylase LpdC. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells lacking this gene are unable to decarboxylate gallic acid and protocatechuic acid.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Gallate decarboxylase does not form a complex composed of Lpdc, LpdB and LpdD. The term subunit has been used in reference to the three-gene operon. Gallate decarboxylase LpdC is the only protein required to yield the gallate decarboxylase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888312.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UT67"/>
    <dbReference type="SMR" id="F9UT67"/>
    <dbReference type="STRING" id="220668.lp_0271"/>
    <dbReference type="EnsemblBacteria" id="CCC77798">
        <property type="protein sequence ID" value="CCC77798"/>
        <property type="gene ID" value="lp_0271"/>
    </dbReference>
    <dbReference type="GeneID" id="57027085"/>
    <dbReference type="KEGG" id="lpl:lp_0271"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.225"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_9"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="PhylomeDB" id="F9UT67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-220-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-19903"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0637">Prenyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000444000" description="Flavin prenyltransferase LpdB">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9HX08"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="20565" checksum="0E33014C231E60BE" modified="2011-10-19" version="1">MKRIVVGITGASGTIYAVDLLEKLHQRPDVEVHLVMSAWAKKNLELETDYSLAQLTALADATYRANDQGAAIASGSFLNDGMVIVPASMKTVAGIAYGFGDNLISRAADVTIKEQRKLVIVPRETPLSVIHLENLTKLAKLGAQIIPPIPAFYNHPQSIQDLVNHQTMKILDAFHIHNETDRRWEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT85</accession>
    <name>F9UT85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylose operon regulator, ROK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylR</name>
        <name evidence="4" type="ordered locus">lp_3172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890717.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3172"/>
    <dbReference type="DNASU" id="1063996"/>
    <dbReference type="EnsemblBacteria" id="CCC80203">
        <property type="protein sequence ID" value="CCC80203"/>
        <property type="gene ID" value="lp_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3172"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2651"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_9"/>
    <dbReference type="OMA" id="AQSAIWR"/>
    <dbReference type="PhylomeDB" id="F9UT85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2691-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="42761" checksum="14CD6D7389B5176D" modified="2011-10-19" version="1">MIINKHVMRSTNEKQVLQQVINEGPISRSQISRNLSLNKVTVSDIYNQLLRTQFIKEIGCGVSTKNGGRKPVMAELNVNYGFVASIDMTADAVKLMYSRLNGKILHFQSFKTSDMTLTDVIDLIEDQLRNVDDYGTIHGLMGVAIALDGIIYENKILKTPIKGLTHFDLAKYLRDKLRIPVVLEKKANLTAVFERDFHDNEIFDNVVSVVVRDQIHAGIVADSRLYSGHEGEAGEVGTALLEDRHVEDHLASVNDYASEKALWARLKAIKHVERLDLTTVKHDYINHDPEVTKVFDDFVYYLSKVIANVSTAFAPDVVVLNTTVLEILPQLLTNVRESTAKLTSPSRQVPIIATKNVQSAALLGGASVIIHQALGLESLKMQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD4</accession>
    <name>F9UTD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102087.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890766.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3233"/>
    <dbReference type="EnsemblBacteria" id="CCC80252">
        <property type="protein sequence ID" value="CCC80252"/>
        <property type="gene ID" value="lp_3233"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3233"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2700"/>
    <dbReference type="eggNOG" id="ENOG5030B1B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030011_4_0_9"/>
    <dbReference type="OMA" id="MARKSAY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2740-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="408" mass="45961" checksum="B0C17415C5237188" modified="2011-10-19" version="1">MANFKVGCGKAMIQFSASELPIREFKSKLDDLYCRVMLISGKNSWALISFDLTSLRAAAIKRYQELAARLLAIDSNQIWVTVTHTFAAPHLPSTTDSMARKSAYRLIDEKLKESLMLACRQAHEDLQAVQVGQVNINCPLNVNRNVLTKQGWWLGRNLEGYSNHQLRVLAFRKADKTTNLLVNYDIQQSVLDHVTDDHGEQMISSDLMGNGIKAYEGNDRVAIFIPGCAGDQRPLFTGKANQPFAVNKALLANQATIVTEKLEWAVQNVHDWQPLRQLRSSQLPVIVPTQVQQRSTFEIKPTKTYDFQSTKQTTTLHLWALRLNQYEIVGTEPELNSSFGDSCRQALAGNTNTMIATLVNGAAKYLPEQIDFERITYQSMNTQLGLTADQCMLEACVQLRQKISEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF6</accession>
    <name>F9UTF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrosqualene desaturase</fullName>
            <ecNumber evidence="5">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtN</name>
        <name evidence="5" type="ordered locus">lp_3262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890788.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3262"/>
    <dbReference type="DNASU" id="1061491"/>
    <dbReference type="EnsemblBacteria" id="CCC80274">
        <property type="protein sequence ID" value="CCC80274"/>
        <property type="gene ID" value="lp_3262"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3262"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2723"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_9"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="PhylomeDB" id="F9UTF6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2762-MON"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="498" mass="56454" checksum="C12B1FF421DEB31B" modified="2011-10-19" version="1">MKQVSIIGAGIGGLTAAVRLQKLGYNVTIYEQNAQPGGKMNQIVSQGFTFDVGPTIVMMKDIYEEVFRFCGVDPHNYLPFEEVQPLMHLVFGDQSSLDLSRDLPTLIAEINRIAPDDVNGMLNFLADIYHRYTIAKPNFLERSFRNWRDFYNLPALYAGLQLRTFNNAYKNIAKFIKNENLRNSLAFQTLYIGISPYQGPSLYNIIPMIELFYGVYFLKGGMYTVVNSLVKLFKEQGGTLKLATPVQEIIIKDKVAVGIRVNNHPIHSDYVLCNADFPTAMTTLIPNEQDRGQYTDQKIAKMDYSCSCLVLYLGLDKKYPTEALHTIHFAQDFSKNVADLFDNGKLPEDPSYYVYVPSKMDPSLAPENSEALYVLVPVPELSKFNDWSPTTLKNYRQLIINKLRQTATFSDIEQHIVVEKQFTPVDFKEQFGAYNGATFGLRPTLKQSNYYRPHNKFDYADHLYFCGSSTHPGAGVPIVMQSAKLAVEELIKDDQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI8</accession>
    <name>F9UTI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacteriocin transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642519.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890820.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3301"/>
    <dbReference type="EnsemblBacteria" id="CCC80306">
        <property type="protein sequence ID" value="CCC80306"/>
        <property type="gene ID" value="lp_3301"/>
    </dbReference>
    <dbReference type="GeneID" id="57026568"/>
    <dbReference type="GeneID" id="66450834"/>
    <dbReference type="KEGG" id="lpl:lp_3301"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2757"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092720_6_0_9"/>
    <dbReference type="OMA" id="MVAIFMQ"/>
    <dbReference type="PhylomeDB" id="F9UTI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2794-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="177" mass="19405" checksum="479D668769396746" modified="2011-10-19" version="1">MIFTIVILILLASAIFRGFHRGFVIEMLHLIGTVVVLLFARLLYQPLGTMISNLLTNLHLIEASVAATLIINLVAFFVLISLGWSVIRLLGRVSRSITWLPVIKQVNSVAGGIVSFVVTYLVIFVALSLANIVNTSFIQTQMTQSPLATYIVKQTPGLTSHYLSNLINFNDGTTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI9</accession>
    <name>F9UTI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal ion ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890821.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3302"/>
    <dbReference type="EnsemblBacteria" id="CCC80307">
        <property type="protein sequence ID" value="CCC80307"/>
        <property type="gene ID" value="lp_3302"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3302"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2758"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_0_0_9"/>
    <dbReference type="OMA" id="LNEHVWY"/>
    <dbReference type="PhylomeDB" id="F9UTI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2795-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388147" evidence="4">
        <location>
            <begin position="26"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="33903" checksum="E49B75759882324B" modified="2011-10-19" version="1">MVNRRIWLYLAIILGLSGLLAGCQSSSTPSKTTNDKINIMASLDFYGQTAKAVAGKYGQVTSIIDRPSVDPHDYEPTVNTAKQASSAQLIIYNGLGYDDWMENLTVNKAKGARVITVGTDVAHKTDGANEHVWYDPTTMPKLATKIATELSKIQPQHKHYFEQQAQKYQTNAKTITTMIKQLKQHANNQRVAVSEPVFDYSLKAIGYRISNTHFAHAIEEGSDPSPKDIQQMQQDIKHHRIAFFVENTQTDSNLVTNMVKLARKYDVPVLKVTETLPANQTYQSWMLSQYRQLAKIQKATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL7</accession>
    <name>F9UTL7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, TMR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102119.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890849.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3343"/>
    <dbReference type="DNASU" id="1063929"/>
    <dbReference type="EnsemblBacteria" id="CCC80335">
        <property type="protein sequence ID" value="CCC80335"/>
        <property type="gene ID" value="lp_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3343"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2787"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_9"/>
    <dbReference type="OMA" id="WFMQNFS"/>
    <dbReference type="PhylomeDB" id="F9UTL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2824-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="286" mass="32849" checksum="44DE00CC4A3FA517" modified="2011-10-19" version="1">MKILVIGGTGNIGLPLIQYLDQQVGVQVVAGAHNLHKDEQLLATYPDVEIRRFDFLDETTFDAALRGIQKVFFVRPPQLAKPKQDMWPFLKCLQAHHIEQVVFVSLMGVEHNPMTPHHQIEQMIEQLQLPYTFIRPSFFMQNLNTTHRVDIQQNHDLFIPAGRSKTSFIDTRDIGEIAGVALLDTQYLQQKLTVTGPEALTYQQIAALMTESFGHPVTYHRPSLWRFRRVMLKRGIKKDYVNVMVMLYLITQLGNAKRVTDTAEKVLGHAPHTMTTYLRDYADQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR4</accession>
    <name>F9UTR4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ack2</name>
        <name evidence="6" type="synonym">ackA</name>
        <name evidence="8" type="ordered locus">lp_0310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888348.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0310"/>
    <dbReference type="EnsemblBacteria" id="CCC77834">
        <property type="protein sequence ID" value="CCC77834"/>
        <property type="gene ID" value="lp_0310"/>
    </dbReference>
    <dbReference type="GeneID" id="57027121"/>
    <dbReference type="GeneID" id="66448401"/>
    <dbReference type="KEGG" id="lpl:lp_0310"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.263"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_9"/>
    <dbReference type="OMA" id="FMMQKEN"/>
    <dbReference type="PhylomeDB" id="F9UTR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-256-MON"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="43848" checksum="93EE9243DD71C84A" modified="2011-10-19" version="1">MAKILAINAGSSTLKWKLFSVPEETVIASGMVDRLGLPDSVFTIKKADGSKYSETKDQIDAKEAAAMVLTRLKSDNIVTHLSEITGVGHRVVAGGEDFKDSVVITSQTLKKIKDLSEYAPLHNPTQAYYIEVFRDLLPKATQVAVFDTSLYADMPKVNYLYSIPYDYYEKFGARKYGAHGTSHRYVANRTAQLLGKPLDSLKLVTLHLGSGASITAFDHGKAVDTSMGFTPLAGITMSTRSGDIDASIIPFLMRHLGISDVEDFVDILNHKSGLLGISGLSPDMRDLDKTQDTRERSKLAIDIFVNRVVKYVGSYIAEMNGIDALVFTAGVGENSWMIRERVTKALGYFGVTVDDEKNHMHGKEQIISKDDEPVTVMVVPTNEELMIVRDVERLSKAE</sequence>
</entry>
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    <accession>F9UTV0</accession>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888384.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77870">
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        <property type="gene ID" value="lp_0351"/>
    </dbReference>
    <dbReference type="GeneID" id="57027161"/>
    <dbReference type="KEGG" id="lpl:lp_0351"/>
    <dbReference type="eggNOG" id="ENOG5030U62">
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    <dbReference type="HOGENOM" id="CLU_2465119_0_0_9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77870.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="89" mass="9764" checksum="CC263DAD53878254" modified="2011-10-19" version="1">MRRQLTNRQRWFVIVIATILGVGCALLGQWGQFFGVIAATFALMLLTSGCLTFCHRRGWQPGSGMLLALVTATGYVLVILGSYGYLLHS</sequence>
</entry>
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    <accession>F9UU07</accession>
    <name>F9UU07_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin peptide PlnF</fullName>
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        <name evidence="1" type="ordered locus">lp_0421</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
    <dbReference type="SMR" id="F9UU07"/>
    <dbReference type="STRING" id="220668.lp_0421"/>
    <dbReference type="EnsemblBacteria" id="CCC77927">
        <property type="protein sequence ID" value="CCC77927"/>
        <property type="gene ID" value="lp_0421"/>
    </dbReference>
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    <dbReference type="GeneID" id="66448497"/>
    <dbReference type="KEGG" id="lpl:lp_0421"/>
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    </dbReference>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-349-MON"/>
    <dbReference type="EvolutionaryTrace" id="F9UU07"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="52" mass="5733" checksum="EB1DF53A46F03739" modified="2011-12-14" version="1">MKKFLVLRDRELNAISGGVFHAYSARGVRNNYKSAVGPADWVISAVRGFIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU59</accession>
    <name>F9UU59_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102129.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890875.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80361">
        <property type="protein sequence ID" value="CCC80361"/>
        <property type="gene ID" value="lp_3375"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.2814"/>
    <dbReference type="eggNOG" id="ENOG5030B5H">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193613_0_0_9"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="13065" checksum="6EA0C68E674D9E0F" modified="2011-10-19" version="1">MEQWYRDARSYLKKYRFYHSVVSQPFEDWLGIGKPKRLQQMELYCQQVTNAIDSIRDERQANLLRNEFVVADGSQRVAYELSGLSKSQYYVIRKQAMREWLQLINQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC4</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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    </reference>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        </source>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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    <feature type="chain" id="PRO_5003394435" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="160"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="37368" checksum="23AA4C544F5FE6BB" modified="2011-10-19" version="1">MKKIFWQLIAVVSIVMAGLTMTARADDLNYTVQADLPDNQINQKVSYFDLKVTPGQTQNLTLTIKNSDSKEHRYTVSPNLAVTNNNGIIDYSQAKAKADDSLKFNIKTALSKSQVVTVPAKSSKKVTIKLTVPEKKFAGVALGGINIIQELSTKAKQSSSGMAINNQYAYVIGLQLRESDPSGIKPVMKLHAVKAKQRNYRNYVTANLQNNQPVIMHGLKIKSYVTKAGSSKKLLTTTKENMSMAPNSNFDFAVGDGTQQLKAGKYTLHLTATADKGKWQFTKNFTITDKEAQTLNDTAVTEKQSNYFWWFVALGALIVVLLGAIIWLLLKNRRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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        <name evidence="9" type="ordered locus">lp_3472</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCC80441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102177.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3472"/>
    <dbReference type="EnsemblBacteria" id="CCC80441">
        <property type="protein sequence ID" value="CCC80441"/>
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    </dbReference>
    <dbReference type="GeneID" id="57026687"/>
    <dbReference type="KEGG" id="lpl:lp_3472"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2889"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="426" mass="46381" checksum="7B35BBCB10C24821" modified="2011-10-19" version="1">MVDEKVKLSKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFVIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTMGILLSQFIGFITANSGMGSPAALFGWIGLVAIINWCVRVFSKRFKQIETDLVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWNLPANTWGSFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYSGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVIIVAIIKKTGLKDPTMKAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="5" type="ordered locus">lp_3476</name>
    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890958.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3476"/>
    <dbReference type="EnsemblBacteria" id="CCC80444">
        <property type="protein sequence ID" value="CCC80444"/>
        <property type="gene ID" value="lp_3476"/>
    </dbReference>
    <dbReference type="GeneID" id="57026690"/>
    <dbReference type="KEGG" id="lpl:lp_3476"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2892"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="OMA" id="YKIFRKY"/>
    <dbReference type="PhylomeDB" id="F9UUE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2932-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="224"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="37726" checksum="968C8A3FFC2DB1E0" modified="2011-10-19" version="1">MTSKFLNYELFALTPVELKQRQSHGNVNYMDLDYVNNPIPQMPRSDFFKHGDIAVTKNNRFSYVPAHTHSFIELNYMYAGTCTQYINGEKVTLHQHNLILMDKDIVQQIESTGSNDILINILLKNDSTMNQLFDYIAVSTNEITQFLYNASHINTLHNNFILFDLTHQEVAINLVESLIIKGLTKSRQRNKSMGLLLSTLILELSQSIEQEYINFSDNTDDNLLPIIQYINQNFASVTLRDVSAKFSYNTNYLGNKLKEATGKTFKELVDRRRISAAQNLMIKTNCTLADICDIIGYQNTSSLFRLFKKYLKTTPSEYKRKVSGPLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ3</accession>
    <name>F9UUJ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trehalose phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">treP</name>
        <name evidence="7" type="ordered locus">lp_3530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.64" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102206.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3530"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80495">
        <property type="protein sequence ID" value="CCC80495"/>
        <property type="gene ID" value="lp_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3530"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2943"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_2_9"/>
    <dbReference type="OMA" id="NMYLPYN"/>
    <dbReference type="PhylomeDB" id="F9UUJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2983-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047656">
        <property type="term" value="F:alpha,alpha-trehalose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="305"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="679"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="569"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="734" mass="83606" checksum="85D1D05CA3484917" modified="2011-10-19" version="1">MQIDKLTLKDVATTNRQYLETIFALGDGHMGVRDSVPFTGNQQATLPVMLINGYYATNPITYGESAYGYAKNHQTIISLTSPRYLDFATEKTSSEIPGDWDMTVDDAVLDFDTGVLTEKFQIVTSDDHHFELVVKSMIALDNSHQLFLNYELTSLDYTGTLRFTRPTIHDVTATTADADDPRVAQRQSGLTNQFIPADRQQQIEWQTLVASTHQQITQRDWLTSFPTGFEVYGDHAGFHGSGTIEVQTTLSWSFTRQISEINQALPDTITSWTNDIVDRNRQILTNFWQQSQVQISDKKLQTGIQYNLFQLFQSAGRNGLTNIAAKGITGPGYEGHYFWDTEMYMLPFFIYTQPQIAKQLLHYRFSILPQARERARSLGVTRGALYAWRTINGEEASAYFPAGTAQYHINADIAHTVKLYFDVTNDQNFLREQGAAVVLETARFWLQFGSWQQRDGRSQFCLYKVTGPDEYTALVDNNYYTNRMAKENMAFAAWLLENHYIDGDADEQAQFTKASTNMYLPYDQEQQVTAQDDNSPKMPVWPFATTAATQYPLLLHYHPLMIYRHRVNKQADTLLAEMLFPEDQSLEQLRRDYEYYEPITTHDSSLSRSIFSILASRLGDHDKAFSYYMDTSLMDLVDLQGNAKDGLHEANLGGSWLGLTYGFAGMYVADGKLHITNHLPTQITHLSYRLRFRGRVLEVQLYQDKTQVKLVTGLPLAVVVAGKEYDVLQGARSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-11" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O08317</accession>
    <accession>F9UL02</accession>
    <name>CARX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Carbamoyl-phosphate synthase arginine-specific small chain</fullName>
            <ecNumber>6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbamoyl-phosphate synthetase glutamine chain</fullName>
            <shortName>CPS-A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">carA</name>
        <name type="ordered locus">lp_0527</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3416" last="3422">
            <title>In Lactobacillus plantarum, carbamoyl phosphate is synthesized by two carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the arginine-repressed from the pyrimidine-regulated CPS.</title>
            <authorList>
                <person name="Nicoloff H."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
            <dbReference type="PubMed" id="10852872"/>
            <dbReference type="DOI" id="10.1128/JB.182.12.3416-3422.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text>Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="induction">
        <text>Repressed by arginine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68238.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101043.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08317"/>
    <dbReference type="SMR" id="O08317"/>
    <dbReference type="STRING" id="220668.lp_0527"/>
    <dbReference type="MEROPS" id="C26.963"/>
    <dbReference type="EnsemblBacteria" id="CCC78017">
        <property type="protein sequence ID" value="CCC78017"/>
        <property type="gene ID" value="lp_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0527"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.435"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_9"/>
    <dbReference type="OMA" id="SQNHSYV"/>
    <dbReference type="PhylomeDB" id="O08317"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-438-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000112287" description="Carbamoyl-phosphate synthase arginine-specific small chain">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1">
        <location>
            <begin position="166"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1 and 4." evidence="2" ref="1 4">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1 and 4." evidence="2" ref="1 4">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="355" mass="38187" checksum="5DABA5C1657DD89B" modified="2003-03-25" version="3">MNKYLTLADGTQWIGTAIGDCQLEAAGRIVFNTGMTGYQETLTDPSYLNQMIAFTYPLIGNYGIDPTVAQAPTIGAQAIIVHELATFNDHYTSRQSLASFLTIHHVAGIEGVDTRDLTIHIRQTGAQMAILSNHPITDFEAQLATFAPQVLTATPLPVATTTIRPRVAILNFGEKAAITAELQARGADVVVLPPTASLKAVAAYHPDGILLSNGPGDPTDYHTYLATIRQLAQRYPLAGICLGHQLIALAYGAQTYQLSFGHHGLNHPVQACADGRIIMTSQNHDYAVDPASIKGTPLIVTHTELNDGSIEGLRLPHQAVMSVQFHPEAHPGPQEAGQFFDDFLLTIQKEAVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q877R5</accession>
    <name>Q877R5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 22</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0645</name>
        <name evidence="2" type="ordered locus">lp_2435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="2">WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="2">WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888637.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0645"/>
    <dbReference type="EnsemblBacteria" id="CCC78123">
        <property type="protein sequence ID" value="CCC78123"/>
        <property type="gene ID" value="lp_0645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79614">
        <property type="protein sequence ID" value="CCC79614"/>
        <property type="gene ID" value="lp_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0645"/>
    <dbReference type="KEGG" id="lpl:lp_2435"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2058"/>
    <dbReference type="eggNOG" id="ENOG5033WTY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575346_0_0_9"/>
    <dbReference type="OMA" id="KFNERDA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2100-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-556-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="176" mass="20409" checksum="6B2E7778F163C80A" modified="2003-06-01" version="1">MIDDISTAFKWNQKDALFAEQILAYEGTPAAIKYFSAHSSELSDYGYWFFLSTLWVSYTEYSDLKIWKTLFASQRPNKAIGIMKPSELKAFDNLPNKLTLYRAHRPNESDWIAYTLDTTVAKHFAKEHKVNQISVYRVKKNHVLALFLRRSEQEIIVLDKSLVKLKKIIPLSEVSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S38</accession>
    <accession>F9ULG0</accession>
    <name>IOLG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.18</ecNumber>
            <ecNumber evidence="1">1.1.1.369</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase</fullName>
            <shortName evidence="1">MI 2-dehydrogenase/DCI 3-dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolG</name>
        <name type="ordered locus">lp_3606</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose</text>
            <dbReference type="Rhea" id="RHEA:16949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine</text>
            <dbReference type="Rhea" id="RHEA:25832"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27372"/>
            <dbReference type="ChEBI" id="CHEBI:50920"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.369"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="1"/>
    <dbReference type="EC" id="1.1.1.369" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S38"/>
    <dbReference type="SMR" id="Q88S38"/>
    <dbReference type="STRING" id="220668.lp_3606"/>
    <dbReference type="EnsemblBacteria" id="CCC80567">
        <property type="protein sequence ID" value="CCC80567"/>
        <property type="gene ID" value="lp_3606"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3606"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3010"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_1_9"/>
    <dbReference type="OMA" id="VNCKYGY"/>
    <dbReference type="PhylomeDB" id="Q88S38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3054-MON"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000352573" description="Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01671"/>
        </source>
    </evidence>
    <sequence length="350" mass="39180" checksum="B17862B12C4514DD" modified="2003-06-01" version="1">MAEAHVTKVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKALDQQGLTATTYEDYHDLVNDPNVEVVVCTANNEAHYEIVMAALKAGKFTFCEKPLALDAKQCMDIIDSEKKLGRRMLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMDQRHYNQTQPEEYDSSRSIIETAIHEIDIDHWLVNDDYANIRVFSPKQTRHVQNAKIQDPQIVMIETKSGINIINEVFVRCQYGYDIKCDVIGEEGVLELPTVPQVATRLNAQYSTAILTDWKARFESAYDIEFRDFINHVSQNESPVGPSAWDGYIAAVTADAALKSLAEDGAKQDLDFPSTPAFYTESEKVSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE0</accession>
    <accession>F9UR74</accession>
    <name>HIS7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="1">IGPD</shortName>
            <ecNumber evidence="1">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisB</name>
        <name type="ordered locus">lp_2558</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644682.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE0"/>
    <dbReference type="SMR" id="Q88UE0"/>
    <dbReference type="STRING" id="220668.lp_2558"/>
    <dbReference type="EnsemblBacteria" id="CCC79713">
        <property type="protein sequence ID" value="CCC79713"/>
        <property type="gene ID" value="lp_2558"/>
    </dbReference>
    <dbReference type="GeneID" id="57025977"/>
    <dbReference type="GeneID" id="66450264"/>
    <dbReference type="KEGG" id="lpl:lp_2558"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2149"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_9"/>
    <dbReference type="PhylomeDB" id="Q88UE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2205-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158135" description="Imidazoleglycerol-phosphate dehydratase">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <sequence length="194" mass="21477" checksum="1B9937E91115603E" modified="2011-11-16" version="2">MRQATIKRETKETQIEISLNLDEQSGIEIDTGIGFLNHMLNLFAKHGRFGLVVKCHGDLDVDPHHTTEDTGIVLGECFKQALGDKQGIERYGTEFVPMDETLGQVSVDLSGRSYLVFDAELTNPRLGGLDTETVEDFFQAVAFAAEMNLHARILYGRNTHHKVESLFKAFGRAMRAAVTINPDIQGVNSTKGVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU0</accession>
    <accession>F9UQR6</accession>
    <name>ATPD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">lp_2367</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU0"/>
    <dbReference type="SMR" id="Q88UU0"/>
    <dbReference type="STRING" id="220668.lp_2367"/>
    <dbReference type="EnsemblBacteria" id="CCC79555">
        <property type="protein sequence ID" value="CCC79555"/>
        <property type="gene ID" value="lp_2367"/>
    </dbReference>
    <dbReference type="GeneID" id="57025899"/>
    <dbReference type="KEGG" id="lpl:lp_2367"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2000"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_4_1_9"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="PhylomeDB" id="Q88UU0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2039-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000184737" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="181" mass="20021" checksum="743CA12C2FA164D6" modified="2003-06-01" version="1">MSLDNLTIASRYSKALFELAVEKDQTEAFLAELKQLRQVFVDNPQLAEVLSGSLLPVDQKQTTLSTLTDHASEYIKNFIQMLYDYGRMSNLVGIVDAFEARFDESRKIVHAEVTSAVKLSDEQADAIAKAFAKRVGANQVVLSRKVDEAIIGGVIVKSNNQTFDGSVALQLTNLRRALINN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UV2</accession>
    <accession>F9UQQ4</accession>
    <name>METN2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine import ATP-binding protein MetN 2</fullName>
            <ecNumber evidence="1">7.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metN2</name>
        <name type="ordered locus">lp_2352</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29767"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57932"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641452.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890057.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UV2"/>
    <dbReference type="SMR" id="Q88UV2"/>
    <dbReference type="STRING" id="220668.lp_2352"/>
    <dbReference type="EnsemblBacteria" id="CCC79543">
        <property type="protein sequence ID" value="CCC79543"/>
        <property type="gene ID" value="lp_2352"/>
    </dbReference>
    <dbReference type="GeneID" id="57025887"/>
    <dbReference type="KEGG" id="lpl:lp_2352"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1988"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_9"/>
    <dbReference type="OMA" id="VIRKICH"/>
    <dbReference type="PhylomeDB" id="Q88UV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2027-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51264">
        <property type="entry name" value="METN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270317" description="Methionine import ATP-binding protein MetN 2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01719"/>
        </source>
    </evidence>
    <sequence length="343" mass="37699" checksum="BB57D493A89B0E08" modified="2003-06-01" version="1">MIEFKDVTKTFDAKQGAVHAVQDVNLKIEDGHIYGIVGYSGAGKSTLVRMLNGLETPTSGSVVIDDVNITTLSGAKLRAQRQKIGMIFQHFNLLWSRTVLENIMFPLEIAGLSKVDARKKAEHLADLVGLAGRETAYPSELSGGQKQRVGIARALANDPQILLSDEATSALDPQTTDEVLDLLLSINQKLHLTIVLITHEMHVIRKIADHVAVMEAGKIVEQGPVLEVFKRPQQAVTKRFVNEEVTPSLNDTTVVVDQLLAKYPKGTIVQLTFHGDQAQLPIVSEMLKKYPLDLNIIEGGIHQTQEGAIGSLYLQLTGDQEQIKGALAYLQTMRVETEVLNRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UX0</accession>
    <accession>F9UQN6</accession>
    <name>RS4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">lp_2331</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890039.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UX0"/>
    <dbReference type="SMR" id="Q88UX0"/>
    <dbReference type="STRING" id="220668.lp_2331"/>
    <dbReference type="EnsemblBacteria" id="CCC79525">
        <property type="protein sequence ID" value="CCC79525"/>
        <property type="gene ID" value="lp_2331"/>
    </dbReference>
    <dbReference type="GeneID" id="49394498"/>
    <dbReference type="GeneID" id="57025862"/>
    <dbReference type="GeneID" id="66450073"/>
    <dbReference type="KEGG" id="lpl:lp_2331"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1970"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_1_9"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="PhylomeDB" id="Q88UX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2009-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132398" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="202" mass="22963" checksum="E9E355010EAEF5A7" modified="2003-06-01" version="1">MSRYTGPSWKISRRLGMSLSGTGKELARRPYAPGDHGQGRRGKLSEYGTQLREKQKLRMMYGLTERQFANLFIKAGKIREGKHGVNFMILLERRLDNMVYRLGLATTRRQARQLVNHGHITVDGKRVDIPSYEVSVGQVVSVREKSKKLAVITGAVEAVVARPNFVQFDADKLEGSLTRLPEREELEADIDESLIVEYYNKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UZ8</accession>
    <accession>F9UQK8</accession>
    <name>MUTL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutL</name>
        <name type="synonym">hexB</name>
        <name type="ordered locus">lp_2297</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890011.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UZ8"/>
    <dbReference type="SMR" id="Q88UZ8"/>
    <dbReference type="STRING" id="220668.lp_2297"/>
    <dbReference type="EnsemblBacteria" id="CCC79497">
        <property type="protein sequence ID" value="CCC79497"/>
        <property type="gene ID" value="lp_2297"/>
    </dbReference>
    <dbReference type="GeneID" id="57025833"/>
    <dbReference type="KEGG" id="lpl:lp_2297"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1941"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_9"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="PhylomeDB" id="Q88UZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1981-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177949" description="DNA mismatch repair protein MutL">
        <location>
            <begin position="1"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <sequence length="678" mass="74105" checksum="00716FCF9969690F" modified="2003-06-01" version="1">MGKIHELSSVLADQIAAGEVVERPASVVKELVENAVDAHATQVDILVQESGVQSIRVIDDGDGIDDAEVLTAFKRHATSKITSREDLFRVHSLGFRGEALPSIASVADVVMNTSTGATGTSIHYRGGKLLQQSPAPLRQGTDITVTDLFFNTPARLKYLKSPQTELANILDVVNRIALSYPAVAFRLVHNAKELLKTAGRGDLQQVIAGIYGVQNARKMVAIQGSTTDFKLSGFVALPELTRASRQYITVLINGRAIKNQQLTKAVIKGYGSKLMVGRYPIAVIALTMDPLLVDVNVHPTKQEVRLSKEPELAKLVSTTITDRLVDVNLIPSALTNLGSHRREHLNTDQLAMDLNAVSSQYQVADKTTPASTEQFAASLAAATMQPSSATTMVSTTSAQPSAVNRAAVSAVVPSESAASSANQPIMISHRDELTATPVQAFDQRYQSESGALPFGETAEPLETSTAASAPTSEAPDTERFPQLRYLGQMHGTYLLAEADDGMYILDQHAAQERINYEYYRQAIGEVSADQQNLLVPIILDYPTSDVLKIKEKLPLLAELGIHLESFGGNSFIVHAHPTWFKAGQEEDTIREMIDWLLQDDKLTVAQFREKSAIMMSCKRAIKANHHLDDQQARALLAKLPTCENPFNCPHGRPVTVHFTNSDMERMFKRIQDSHEARD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V85</accession>
    <accession>F9UQC2</accession>
    <name>SEPF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sepF</name>
        <name type="ordered locus">lp_2192</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V85"/>
    <dbReference type="SMR" id="Q88V85"/>
    <dbReference type="STRING" id="220668.lp_2192"/>
    <dbReference type="EnsemblBacteria" id="CCC79411">
        <property type="protein sequence ID" value="CCC79411"/>
        <property type="gene ID" value="lp_2192"/>
    </dbReference>
    <dbReference type="GeneID" id="57025720"/>
    <dbReference type="KEGG" id="lpl:lp_2192"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1852"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078499_4_1_9"/>
    <dbReference type="OMA" id="KVGNGIF"/>
    <dbReference type="PhylomeDB" id="Q88V85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1872-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000334023" description="Cell division protein SepF">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="140" mass="15291" checksum="302B541018B45A62" modified="2003-06-01" version="1">MAGFISNFFGVGDSDSQYEEPTEASQAAAPTESATNTRSTPKVVPMQGGKSVNSKIALFEPKIYSDVKEIATQLLKNQAVIINFDHVDDEMARRIVDFLTGTVFAINGEIERIGDEIFLCIPENYEVSGSTTSQFDTSKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VP8</accession>
    <accession>F9UPV4</accession>
    <name>3MGH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1991</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889757.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VP8"/>
    <dbReference type="SMR" id="Q88VP8"/>
    <dbReference type="STRING" id="220668.lp_1991"/>
    <dbReference type="EnsemblBacteria" id="CCC79243">
        <property type="protein sequence ID" value="CCC79243"/>
        <property type="gene ID" value="lp_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1991"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1683"/>
    <dbReference type="eggNOG" id="COG2094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_2_0_9"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="PhylomeDB" id="Q88VP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1707-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100088" description="Putative 3-methyladenine DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <sequence length="209" mass="23153" checksum="80A65B45F099E6C4" modified="2003-06-01" version="1">MTAIERFLSTCTTPEIAVSLLGKQLRLQTSSGVLTAWITETEAYLGARDAGAHAYQNHQTPRNHALWQSAGTIYIYQMRAWCLLNIVTQAAGTPECVLIRGIEPDAGLERMQQQRPVPIANLTNGPGKLMQALGLDKTLNGQALQPATLSLDLSHYRQPEQVVATPRIGIVNKGEWTTAPLRYFVAGNPFVSKISRRTIDHEHHGWMTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W28</accession>
    <accession>F9UPH7</accession>
    <name>PLSY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">G3P acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="1">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsY</name>
        <name type="ordered locus">lp_1842</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644419.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889630.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W28"/>
    <dbReference type="SMR" id="Q88W28"/>
    <dbReference type="STRING" id="220668.lp_1842"/>
    <dbReference type="EnsemblBacteria" id="CCC79116">
        <property type="protein sequence ID" value="CCC79116"/>
        <property type="gene ID" value="lp_1842"/>
    </dbReference>
    <dbReference type="GeneID" id="57025436"/>
    <dbReference type="KEGG" id="lpl:lp_1842"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1553"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_4_0_9"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="PhylomeDB" id="Q88W28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1579-MON"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000188388" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <sequence length="208" mass="23016" checksum="5C5C6CE5E80790C3" modified="2003-06-01" version="1">MKIIIMLIIAYLIGAIPSGVIIGKFFFHTDIRQAGSGNIGTTNTYRVLGPTAGTIVMVMDILKGTIAALQPTLLFHMNNRYTLLIGLAAILGHTFSIYIGFKGGKAVATSAGILLAYNWEFFLIASAIMLLLVYTTSMVSVASMTAFPIVTLIAIFYYQDWLLSLVAFALTLFIFYRHRSNIARIKNGTESLVHFGLGWRRQQRANRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WV2</accession>
    <accession>F9UNP8</accession>
    <name>NRDR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdR</name>
        <name type="ordered locus">lp_1511</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889351.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WV2"/>
    <dbReference type="SMR" id="Q88WV2"/>
    <dbReference type="STRING" id="220668.lp_1511"/>
    <dbReference type="EnsemblBacteria" id="CCC78837">
        <property type="protein sequence ID" value="CCC78837"/>
        <property type="gene ID" value="lp_1511"/>
    </dbReference>
    <dbReference type="GeneID" id="57025108"/>
    <dbReference type="GeneID" id="66449397"/>
    <dbReference type="KEGG" id="lpl:lp_1511"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1271"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_9"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="PhylomeDB" id="Q88WV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1298-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000182307" description="Transcriptional repressor NrdR">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="171" mass="19886" checksum="F74476F575E87CD0" modified="2003-06-01" version="1">MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREEFNREKVLRGIIRSAEKRPVSMETMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADIDEISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSAKTTHAPKRKKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX8</accession>
    <accession>F9UML3</accession>
    <name>RL29_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">lp_1043</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX8"/>
    <dbReference type="SMR" id="Q88XX8"/>
    <dbReference type="STRING" id="220668.lp_1043"/>
    <dbReference type="EnsemblBacteria" id="CCC78452">
        <property type="protein sequence ID" value="CCC78452"/>
        <property type="gene ID" value="lp_1043"/>
    </dbReference>
    <dbReference type="GeneID" id="49393325"/>
    <dbReference type="GeneID" id="57024699"/>
    <dbReference type="GeneID" id="66448955"/>
    <dbReference type="KEGG" id="lpl:lp_1043"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.879"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_9"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="PhylomeDB" id="Q88XX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-895-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000130406" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <sequence length="64" mass="7538" checksum="2357F52F5704033F" modified="2003-06-01" version="1">MKAKEIKALSTTEMLEKEKSYKDELFNLRFQLATGQLENTARLKQVRKNIARIKTALREQELNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YG1</accession>
    <accession>F9UM26</accession>
    <name>UNG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil-DNA glycosylase</fullName>
            <shortName evidence="1">UDG</shortName>
            <ecNumber evidence="1">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ung</name>
        <name type="ordered locus">lp_0806</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643980.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888779.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YG1"/>
    <dbReference type="SMR" id="Q88YG1"/>
    <dbReference type="STRING" id="220668.lp_0806"/>
    <dbReference type="EnsemblBacteria" id="CCC78265">
        <property type="protein sequence ID" value="CCC78265"/>
        <property type="gene ID" value="lp_0806"/>
    </dbReference>
    <dbReference type="GeneID" id="57024506"/>
    <dbReference type="KEGG" id="lpl:lp_0806"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.682"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_9"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="PhylomeDB" id="Q88YG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-701-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176108" description="Uracil-DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <sequence length="230" mass="26076" checksum="11470E86B26C7096" modified="2003-06-20" version="1">MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVVILGQDPYHGPGQAHGLSFSVLPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVLLLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVVFILWGKAARSKIKLIDTQTNVVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YH3</accession>
    <accession>F9UM13</accession>
    <name>ENO1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase 1</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno1</name>
        <name type="synonym">enoA</name>
        <name type="synonym">enoA1</name>
        <name type="ordered locus">lp_0792</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888766.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YH3"/>
    <dbReference type="SMR" id="Q88YH3"/>
    <dbReference type="STRING" id="220668.lp_0792"/>
    <dbReference type="MoonProt" id="Q88YH3"/>
    <dbReference type="PRIDE" id="Q88YH3"/>
    <dbReference type="EnsemblBacteria" id="CCC78252">
        <property type="protein sequence ID" value="CCC78252"/>
        <property type="gene ID" value="lp_0792"/>
    </dbReference>
    <dbReference type="GeneID" id="57024494"/>
    <dbReference type="GeneID" id="66448756"/>
    <dbReference type="KEGG" id="lpl:lp_0792"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.669"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_9"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="PhylomeDB" id="Q88YH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-688-MON"/>
    <dbReference type="BRENDA" id="4.2.1.11">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133906" description="Enolase 1">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="442" mass="48030" checksum="B4FD3E75AA7359D4" modified="2003-06-01" version="1">MSIITDIYAREVLDSRGNPTVEVELYTESGAFGRGIVPSGASTGEHEAVELRDGDKSRFMGKGVTKAVDNVNKLIAKEIVGYDVTDQRAIDQAMIKLDGTPNKAKLGANAILGVSIAAARAAADELEMPLYNYLGGFNAHVLPTPMMNVINGGAHANNDVDFQEFMIMPVGASSVKEAIRMGSETFHNLKAILNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIERAGYKPGKDIAIAFDCAASEFYNEETGKYDLKGEGENGQSFTAEEFVDLLDSIVDKYPIVSIEDPLDENNWEDWQMATAKLGKKVQIVGDDLFVTNTDYLAKGIKMGVANSILIKVNQIGTLTETVEAIEMAKEAGYTAIVSHRSGETEDTTIADLVVAMNAGQIKTGSMSRTERIAKYNQLMRIEDQLESTSEYKGIHGFYNLDEAARNTITSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YY5</accession>
    <accession>F9UL69</accession>
    <name>RPIA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoriboisomerase A</fullName>
            <shortName evidence="1">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpiA</name>
        <name type="synonym">rpiA1</name>
        <name type="ordered locus">lp_0602</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888598.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YY5"/>
    <dbReference type="SMR" id="Q88YY5"/>
    <dbReference type="STRING" id="220668.lp_0602"/>
    <dbReference type="EnsemblBacteria" id="CCC78084">
        <property type="protein sequence ID" value="CCC78084"/>
        <property type="gene ID" value="lp_0602"/>
    </dbReference>
    <dbReference type="GeneID" id="57024379"/>
    <dbReference type="GeneID" id="66448646"/>
    <dbReference type="KEGG" id="lpl:lp_0602"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.503"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_9"/>
    <dbReference type="OMA" id="FIDICDT"/>
    <dbReference type="PhylomeDB" id="Q88YY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-515-MON"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158428" description="Ribose-5-phosphate isomerase A">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <sequence length="227" mass="24642" checksum="C7AC1C2B01AAFADD" modified="2003-06-01" version="1">MNQDQLKQLVGQKAVEYIQDGMQVGLGTGSTVKFMVDALGERVKNEHLNIVGVSTSDRTAAQAKALGIPMKSVDEVDHLDLTIDGADEIADDFQGVKGGGAALLFEKIVAINSDKVMWIVDESKMVHQLGAFGLPVEVIPYGSQHVFEKMAARGYNPVFRKVNDELVRTDSNNIIIDLHIDPITDPHALAEDLIHMVGVVEHGLFLDMVNTVIVGHANGPEVIEARP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZF1</accession>
    <accession>F9UTW7</accession>
    <name>GLPK1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase 1</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase 1</fullName>
            <shortName evidence="1">GK 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK1</name>
        <name type="ordered locus">lp_0370</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643773.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888401.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZF1"/>
    <dbReference type="SMR" id="Q88ZF1"/>
    <dbReference type="STRING" id="220668.lp_0370"/>
    <dbReference type="EnsemblBacteria" id="CCC77887">
        <property type="protein sequence ID" value="CCC77887"/>
        <property type="gene ID" value="lp_0370"/>
    </dbReference>
    <dbReference type="GeneID" id="57027177"/>
    <dbReference type="KEGG" id="lpl:lp_0370"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.314"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_9"/>
    <dbReference type="OMA" id="VQWMRDQ"/>
    <dbReference type="PhylomeDB" id="Q88ZF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-309-MON"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059460" description="Glycerol kinase 1">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="505" mass="55818" checksum="09D135885F9AB76A" modified="2003-06-01" version="1">MTDKYIMAIDEGTTSTRAIIFDHAGHKVADSQREFPQYFPQPGWVEHNANEIWNAVLSTIANAFIESGIKPAQISGIGITNQRETTIVWDKQTGLPIYNAIVWQSRQTAPIAEKLVKDGYGDLIHQHTGLVTDAYFSATKIRWILDHVKGAQERAEKGELLFGTIDTWLLWKLTGGATHVTDYSNASRTMLFNIHDLKWDDQILQLLNIPAAMLPEVRTNSEVYGKTKDYHFFGSEVPISGMAGDQQAALFGQLAFEPGTVKNTYGTGAFIVMNTGEKPQLSDNNLLTTIGYGINGKVYYALEGSIFVAGSAIQWLRDGIRLVESAPDSERAARESHNENEVYVVPAFTGLGAPYWDSEARGSVFGLTRGTTREDFIKATLQALAYQTRDVVETMKKDSGIEIPVLKVDGGAARNDWLMQFQADILDTQIMRAANLETTALGAAFLAGLSVGYWQDLEELKASYKPGTSFDPEMGPAERTNLYEGWQAAVKATQVFKHTPYHAGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q890J4</accession>
    <accession>F9US47</accession>
    <name>PROA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">lp_0017</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890J4"/>
    <dbReference type="SMR" id="Q890J4"/>
    <dbReference type="STRING" id="220668.lp_0017"/>
    <dbReference type="EnsemblBacteria" id="CCC77594">
        <property type="protein sequence ID" value="CCC77594"/>
        <property type="gene ID" value="lp_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="57026879"/>
    <dbReference type="KEGG" id="lpl:lp_0017"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.15"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_9"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="PhylomeDB" id="Q890J4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-15-MON"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000189737" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <sequence length="412" mass="44621" checksum="A018200E654DE926" modified="2003-06-01" version="1">MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVKFVDRLRLTADRIQDMAIGLKQVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEARPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRGALRAEAVDENAIQLITDTSHATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDIVINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPATDADWGTEYNDLIIAVKVVDSEAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVYINASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSYKYVIDGNGQIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL10</accession>
    <name>F9UL10_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell surface protein, ErfK/YbiS/YcfS/YnhG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0536"/>
    <dbReference type="MEROPS" id="C82.001"/>
    <dbReference type="EnsemblBacteria" id="CCC78025">
        <property type="protein sequence ID" value="CCC78025"/>
        <property type="gene ID" value="lp_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0536"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.443"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022707_2_1_9"/>
    <dbReference type="OMA" id="WYFQDKA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-446-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143985">
        <property type="entry name" value="SSF143985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="205"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="340"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="464" mass="51127" checksum="5B6F2449ED8F8DBB" modified="2011-10-19" version="1">MKHKRGLMIGGSILGLLVIGYVATSLIWQHQQTFLSNTSVAGVDVSGKTAAQAAPKVNRALEHRTYRIIENGQTKYSFTSKSAGITINTKKDLTKLVTKQNYWRWPLALLQSAQADDSSAVGQLTINHTDLKTLLQKITTTANQTKRTKTENAKLVYQHNQVEIKKEVQGTELDQAKLKTVVTKAISNGDSHITLKDAYVTPTVTSTSASLKTAKAKSAKYATEKATYNINGHKFTIPHDLILSWIKVDKQGKVSLDQNAVLTYVKQLNDKYHTYHTTRQFKSTARGTVSVSGGFYGWTIKTEAEAKALATEILKGKDFTRSPITSGSGYNNKGTDIGNTYVEVDKENQHMYVYVDGKLTVSTDIVTGKPGKHATTTGVWYIWNKEKNATLKGDNDDGSSYSQPVSYWMPFDDTGEGIHDSSWQTQYGGTWYKKHGSHGCVNTPPSVMKKVFAAVPVGTPVIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL72</accession>
    <name>F9UL72_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ordered locus">lp_0606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643928.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888601.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0606"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="DNASU" id="1061574"/>
    <dbReference type="EnsemblBacteria" id="CCC78087">
        <property type="protein sequence ID" value="CCC78087"/>
        <property type="gene ID" value="lp_0606"/>
    </dbReference>
    <dbReference type="GeneID" id="57024382"/>
    <dbReference type="GeneID" id="66448649"/>
    <dbReference type="KEGG" id="lpl:lp_0606"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.507"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_9"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="PhylomeDB" id="F9UL72"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-518-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="459" mass="50019" checksum="774C36796B193C73" modified="2011-10-19" version="1">MAKAKTQFVCSNCGYSTPRYLGRCPNCGEWNTLTEEHFDTKPDRKSRVSFAGKSAKPQRLKEVSLTKTPRVKTKLKEFNRVLGGGVVPGSLVLIGGDPGIGKSTLLLQVSGQLAETGGSVLYVTGEESASQVKMRADRLAVSSEDFYLYPETDMSNIRSTIESTHPEFVVIDSVQTMQEPDMDSAIGSVSQIREITAELLQIAKTNGITIFIVGHVTKGGAIAGPKILEHMVDTVLYFEGDLHHTYRILRAVKNRFGSTNELGIFEMRTGGLYEVANPSEIFLEERLKDATGSAIVVSMEGTRPILVEVQALVTPTVFGNAKRTASGLDHNRVSLIMAVLEKRASLMLQNQDAYLKAAGGVKLDEPAIDLAIAVSVASSYRDQQTRPSDCFVGEVGLTGEIRRVNRIESRVGEAAKLGFKRIFIPKNNLQGWDIPTGIEVIGVATLKEALQLALQQPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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    <name>F9UL94_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Prophage P1 protein 8, phage transcription regulator, Cro/CI family</fullName>
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        <name evidence="2" type="ordered locus">lp_0631</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78109.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888623.1">
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    <dbReference type="STRING" id="220668.lp_0631"/>
    <dbReference type="EnsemblBacteria" id="CCC78109">
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        <property type="gene ID" value="lp_0631"/>
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    <dbReference type="GeneID" id="49285119"/>
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    <dbReference type="PhylomeDB" id="F9UL94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-542-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13813" checksum="483D7ECCF23920A8" modified="2011-10-19" version="1">MFAERLKELRKREAGLTQERLAMQLGMAKTTLASYEQGKRQPDLETLSKIADRFSVTTDYLLGKNGTPKWATKKDTIDLKDFLEANEGSMTYGGEDLTEEEKQQVRVAMATIFWKRHKHD</sequence>
</entry>
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    <accession>F9UL95</accession>
    <name>F9UL95_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 9, phage transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0632</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888624.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0632"/>
    <dbReference type="EnsemblBacteria" id="CCC78110">
        <property type="protein sequence ID" value="CCC78110"/>
        <property type="gene ID" value="lp_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0632"/>
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    <dbReference type="OMA" id="DWTIFFE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-543-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="9083" checksum="A888DF9AE6F1D7FF" modified="2011-10-19" version="1">MRHWLKEWRDINGLTQKKAAEFLDMPETTLASYEQGHRTPSVGRAKKMAVRMNDISKKKRVKWTYFFEDKVHNTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC9</accession>
    <name>F9ULC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3574</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC80536">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2862199_0_0_9"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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    <accession>F9ULD7</accession>
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        <submittedName>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80544.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80544">
        <property type="protein sequence ID" value="CCC80544"/>
        <property type="gene ID" value="lp_3581a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3581a"/>
    <dbReference type="eggNOG" id="ENOG5032PH8">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_3291595_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3031-MON"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="InterPro" id="IPR009229">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCC80544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="40" mass="4748" checksum="D71C70FE38C28634" modified="2011-10-19" version="1">MKQKMYEAIAHLFKYVGAKQLVMCCVGIWFETKIPDELRK</sequence>
</entry>
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    <accession>F9ULF4</accession>
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        <name evidence="3" type="primary">pts36B</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102242.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3600"/>
    <dbReference type="EnsemblBacteria" id="CCC80561">
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        <property type="gene ID" value="lp_3600"/>
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    <dbReference type="KEGG" id="lpl:lp_3600"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3005"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF02302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="103" mass="11414" checksum="476B4D05DF7967AF" modified="2011-10-19" version="1">MAKIIVACGSGVASSELVVKHITDFFEDHHITGVEVEATDFKKLPDILANYDVYVWIARPNEEIQTIVDRYGIASVNGLPIFTGQSPETSYRDIITALKNMQS</sequence>
</entry>
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    <accession>F9ULI1</accession>
    <name>F9ULI1_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase, DUF336 family</fullName>
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        <name evidence="1" type="ordered locus">lp_3632</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004891102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3632"/>
    <dbReference type="EnsemblBacteria" id="CCC80588">
        <property type="protein sequence ID" value="CCC80588"/>
        <property type="gene ID" value="lp_3632"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3632"/>
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    <dbReference type="eggNOG" id="COG3538">
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    <dbReference type="HOGENOM" id="CLU_023537_0_0_9"/>
    <dbReference type="OMA" id="QVFECKY"/>
    <dbReference type="PhylomeDB" id="F9ULI1"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="429" mass="48576" checksum="EA5A3DE86277B9A2" modified="2011-10-19" version="1">MTTNYVDQHVQQFVAKVNQLSQPLDPKLGTVFQKTFLNTLETTISDDEQGYAFILTGDIPAMWQRDSTAQVRPYLALAHEQPAIADLITRVVQRQFFNMAIDPYANAFNETANGHGHQSDQTNMGPWIWERKFEIDSLCYPVQLAYLLYKNTGVTAQFDNNFVTGVKKLLTTFEVEQHHATSLYRFIRTIDRPEDTLVRDGRGTPVADTGMIWSGFRPSDDACEYGYLVPANMFAVVILGYLQTIFSSILDDPEIVARAQRLQTTVRNGIETYGYTTNANGEKVYAYEVDGLGHAKLMDDGNVPSLLSAPYLGYCDLLDLNYQRTRQTLLSPENPYYYSGKLAAGQGSPHTPARYIWPIAIAMEGLTANSHEQQLAALQTLIKTTGNTDLMHESFDVDDYTQFTREWFSWANMMYCELLLTTLGFKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ9</accession>
    <name>F9ULJ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, glucitol/sorbitol-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
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    <gene>
        <name evidence="2" type="primary">pts38A</name>
        <name evidence="2" type="ordered locus">lp_3652</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891120.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3652"/>
    <dbReference type="EnsemblBacteria" id="CCC80606">
        <property type="protein sequence ID" value="CCC80606"/>
        <property type="gene ID" value="lp_3652"/>
    </dbReference>
    <dbReference type="GeneID" id="57026832"/>
    <dbReference type="GeneID" id="66451079"/>
    <dbReference type="KEGG" id="lpl:lp_3652"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3050"/>
    <dbReference type="eggNOG" id="COG3731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138435_2_1_9"/>
    <dbReference type="OMA" id="MLITFKQ"/>
    <dbReference type="PhylomeDB" id="F9ULJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3093-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004716">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR40398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03829">
        <property type="entry name" value="PTSIIA_gutA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="13481" checksum="5C478C1D31A12FA7" modified="2011-10-19" version="1">MMTKERIIFSTKVLEIGAESADFKSIGMAVLFGDEAPDALRPSCFIIEVVPISEQITAGMKLEVDNQVYQITAVGGEVQTNLGRLGHTAISFTGAKEAKLPGTLYVEQGDYPDFKVGSVVRIIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULP2</accession>
    <name>F9ULP2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101104.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0653"/>
    <dbReference type="EnsemblBacteria" id="CCC78131">
        <property type="protein sequence ID" value="CCC78131"/>
        <property type="gene ID" value="lp_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0653"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.546"/>
    <dbReference type="eggNOG" id="ENOG5033ART">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107462_5_0_9"/>
    <dbReference type="OMA" id="INGFYAN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-564-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010024">
        <property type="entry name" value="CHP16711"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023385">
        <property type="entry name" value="YopX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019096">
        <property type="entry name" value="YopX_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09643">
        <property type="entry name" value="YopX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01671">
        <property type="entry name" value="phage_TIGR01671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YopX" evidence="1">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13154" checksum="FBD2BB0597C173E0" modified="2011-10-19" version="1">MIKFRVWDNECKVIRDYDELKGLTLDALDASDFKLEQFTGLKDVNGKDIYEGDVLKTKAGLIQIVEQGILETDREDIINGFYANNLSDEKPHTFSYDDEVIGNVHENPELLEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS2</accession>
    <name>F9ULS2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101134.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888675.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78161">
        <property type="protein sequence ID" value="CCC78161"/>
        <property type="gene ID" value="lp_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0684"/>
    <dbReference type="HOGENOM" id="CLU_204550_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-595-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="68" mass="7535" checksum="B1EB306555AB0DF2" modified="2011-10-19" version="1">MSQFNHLNDIPDKIMNCSKCGKKFSISISDGSMWGGHDSESIQCPWCGANNGKEYGGDMIMVFTSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM66</accession>
    <name>F9UM66_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Proline iminopeptidase</fullName>
            <shortName evidence="9">PIP</shortName>
            <ecNumber evidence="4 9">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pepR1</name>
        <name evidence="12" type="ordered locus">lp_0853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the N-terminal proline from various substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888819.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0853"/>
    <dbReference type="ESTHER" id="lacpl-PEPR1">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.004"/>
    <dbReference type="EnsemblBacteria" id="CCC78305">
        <property type="protein sequence ID" value="CCC78305"/>
        <property type="gene ID" value="lp_0853"/>
    </dbReference>
    <dbReference type="GeneID" id="57024546"/>
    <dbReference type="KEGG" id="lpl:lp_0853"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.725"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_0_9"/>
    <dbReference type="OMA" id="PACALRM"/>
    <dbReference type="PhylomeDB" id="F9UM66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-741-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031975">
        <property type="term" value="C:envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="34494" checksum="0A6547E281FA1B87" modified="2011-10-19" version="1">MKQGTTIITLDNGYHLWTNTQGKGDIQLLCLHGGPGGNHEYWENFGEELADLGVQVSMYDQLGSWYSDQPDYSDPEIAKKYLTYDYFLDEVEEVRQKLGLDNFYLIGQSWGGALTMMYALKYGQHLKGAIISSMVDNIEEYVVNVNKCREEALPADAVAYMKQKEAEGNWNDPQYQKYVDVLNAGYVDRKQPTSIRHLINTTATPVYNAFQGDNEFVITGKLKEWDIRDQIHNIKVPTLLTFGEHETMPLASARRMARDIPNSRLVTTPNGGHHHMIDNAPVYFDHLKQFIRDVEDGSFNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMB0</accession>
    <name>F9UMB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein, DedA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888863.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78349">
        <property type="protein sequence ID" value="CCC78349"/>
        <property type="gene ID" value="lp_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0907"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.769"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_9"/>
    <dbReference type="PhylomeDB" id="F9UMB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-785-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="214" mass="23709" checksum="4E4CEC291070BF46" modified="2011-10-19" version="1">MVNLITILTHLEQSIVPLLTTLGSWSYILLFAVIFLETGMVVFPFLPGESLIFLASTMAATHSDALSIQILVPVFFVAAVIGDTVNFEIGRHLIRLPWLQRHLPQSKQQRAQQFFAKYGAKAVMFGRFVPLVRTFVPLSAGAAKMPQTTFAIWNLVGVGIWVSVGCSLGYFFGSISFVQNHLSLCFLGIMAAALIPATVVALIKTWRQQRFSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI0</accession>
    <name>F9UMI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78419">
        <property type="protein sequence ID" value="CCC78419"/>
        <property type="gene ID" value="lp_0995"/>
    </dbReference>
    <dbReference type="GeneID" id="57024659"/>
    <dbReference type="GeneID" id="66448913"/>
    <dbReference type="KEGG" id="lpl:lp_0995"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.842"/>
    <dbReference type="eggNOG" id="ENOG5030AR5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170253_0_0_9"/>
    <dbReference type="OMA" id="MNDINMY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-855-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="114" mass="13027" checksum="055A9841E9CACD70" modified="2011-10-19" version="1">MNDDAQLSITQLDSSLQHKAVEDFAAFYLPLFDANNLEMMSNYDVASYMTDINEHLTYGRYMTKAQRLSDTVSFSFTAYVNLIDRLDQQYFTSGNPALPWNEWLAAKFAQTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ0</accession>
    <name>F9UMJ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">als</name>
        <name evidence="6" type="ordered locus">lp_1005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1005"/>
    <dbReference type="EnsemblBacteria" id="CCC78429">
        <property type="protein sequence ID" value="CCC78429"/>
        <property type="gene ID" value="lp_1005"/>
    </dbReference>
    <dbReference type="GeneID" id="57024669"/>
    <dbReference type="KEGG" id="lpl:lp_1005"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.852"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_2_9"/>
    <dbReference type="OMA" id="DIGSHYI"/>
    <dbReference type="PhylomeDB" id="F9UMJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-865-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034077">
        <property type="term" value="P:butanediol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012782">
        <property type="entry name" value="Acetolactate_synth_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02418">
        <property type="entry name" value="acolac_catab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="199"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="560" mass="61232" checksum="64E52A8B78073879" modified="2011-10-19" version="1">MPDKKYYGADAIVDSLVNHDVKYVFGIPGAKIDRVFERLEHPVNPKSPRLIVTRHEQNAAFIAAGIGRITGKPGVVMTTSGPGASNLATGLVTATAEGDPVLAISGQVQRADLLRLTHQSMNNAALFKPITKYSAEVQEPENISEVLANAYQEATAAKQGASFVSVPQDVTDSIVRTPVITPIQAPKLGPASPVEATLLAQKIKAAKLPVLLVGMRASSPEVTKAIRNLVAAANLPVVETFQAAGVISRDLEANHFFGRVGLFRNQPGDMLLKKSDLVIAVGYDPIEYEPRNWNAEGKSRIVVIDAMRAEIDHNFQPETELIGDIAQTLDFLLPYMKGYDISDSARAYLGELQERLQTRDFVPNIDKQSKLNHPLSVIAALQQRVSDDMTVTVDVGSHYIWMARHFRSYEPRHLLFSNGMQTLGVALPWAIAAALVRPDTQIVSVSGDGGFLFSAQELETAVRLKQNIVHLIWNDGTYDMVKFQEEMKYGEDAAVHFGPVDFVKYAESFGATGLRVNQPADLEKVLDQAFATDGPVVVDIPIDYSDNKALGKTMLPDQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ5</accession>
    <name>F9UMQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L(+)-tartrate dehydratase, subunit B</fullName>
            <ecNumber evidence="4">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttdB</name>
        <name evidence="4" type="ordered locus">lp_1089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003596657.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889008.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1089"/>
    <dbReference type="EnsemblBacteria" id="CCC78494">
        <property type="protein sequence ID" value="CCC78494"/>
        <property type="gene ID" value="lp_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1089"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.923"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_0_0_9"/>
    <dbReference type="OMA" id="YLTGHIT"/>
    <dbReference type="PhylomeDB" id="F9UMQ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-937-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="203" mass="22982" checksum="58FA7A5CC736DA0A" modified="2011-10-19" version="1">MKTYHLTTPISDDDIKDIRIGDIVYLNGSLTTCRDVAHRRLVEEHRPLPVNVTDRAILHAGPIIKDLGHDKYEMVAVGPTTSMRMEKFEEEFVKQTRVKLIVGKGGMGPGTERACKKYHALHLVYPAGNAVYAALHVNKIVDAQWKDLGMPETLWACEVKDFGPLIVSIDTNGDNLFEKNKVIFNERKEAEIKKINEQVKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR4</accession>
    <name>F9UMR4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">citP</name>
        <name evidence="7" type="ordered locus">lp_1102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641299.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889017.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMR4"/>
    <dbReference type="STRING" id="220668.lp_1102"/>
    <dbReference type="EnsemblBacteria" id="CCC78503">
        <property type="protein sequence ID" value="CCC78503"/>
        <property type="gene ID" value="lp_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1102"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.932"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_7_3_9"/>
    <dbReference type="OMA" id="GLNPNAW"/>
    <dbReference type="PhylomeDB" id="F9UMR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-946-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="PTHR42826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="472" mass="50646" checksum="3FB4AD6598AFB6CC" modified="2011-10-19" version="1">MTLNKVKYRDFIAPLLVGLIIWLSSPIKPASVSMNAWHILAIFVATIIGCITRPLPIAGVAIIGLTLTVLLGIVPMDTAVAGFGSSTVWMIAMAYFMSRGFINTGLGRRVALVFVRLFGKRTLGLAYALIGVDLVTAPATPSNTARAGGIVYPIIQSLAETFGSDPKDGTQSKIGSFLVFAEFHGDLITSTMFMTAMAPNLVAVTLAKSLHITLSWMQWFLAGIVPGLICLLVVPYLIYKMYPPEIKDTPNAKQWADDELAKMGKMSLPEKIMGGVFLLALVLWMLSSFIGLEASLVAFMAVSLLLVAGVLSVDDVLHETGAWNTLVWFSILIFMANELNKLGFIPWLSGAIGGALKGFSWGIVLAALVLFYFYSHYLFASGTAHVSAMYGALLGVAVSAGAPATFAALILGFTGSIFASTTHYANGPASVLFGSGYVTQGKWWQLNFILGLFYLVVWGGIGALWMKVIGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX7</accession>
    <name>F9UMX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligosaccharide transporter (Flippase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cps1C</name>
        <name evidence="8" type="ordered locus">lp_1179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1179"/>
    <dbReference type="DNASU" id="1063159"/>
    <dbReference type="EnsemblBacteria" id="CCC78566">
        <property type="protein sequence ID" value="CCC78566"/>
        <property type="gene ID" value="lp_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1179"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.997"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1009-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="322"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="475" mass="53431" checksum="E28AD32BC31AC77C" modified="2011-10-19" version="1">MKIIRNYLYNASYQVLILLTPLITVPYVARVLGPTGVGVYSYTNSIITYFVLIGTLGITVYGNQQIAFHRDDIIERSRTFWEIELLQAVNVGITFLGFGIFLILDHRYQLFMVFQSCQLLAGAFDVSWFFMGIEDFKKTVFRNTLVKIATLGAIFIFVRTQSDLGLYILILALSQLVGNFTLWPYLKTRLVRIKFKDLKIWHHYVPALMLFVPQAANLVYQQVNKTMLGNLDTVNSVAYFDYADKLIKTVLAVVTATGIVMLPHMANLHAKGKNETIKRYLYKSFEFVSMIALPLGFGIAGIATTLAPIYFGQDFSISGKLLIIEAPVILLIGWSNVIGQQYMMPTEQISKYTKSVIIGAIVNVILNVPLIMYLGAVGAPIATVAAELSVTLYQLFVVRKQIQINLLFSDFWKYLFSSTVMFIVVYGLNVSMPMSIINLIVQIVEGMIIYLGMLLVLQPKLVVEGKSLLLGKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN39</accession>
    <name>F9UN39_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport protein, DUF20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1247"/>
    <dbReference type="EnsemblBacteria" id="CCC78628">
        <property type="protein sequence ID" value="CCC78628"/>
        <property type="gene ID" value="lp_1247"/>
    </dbReference>
    <dbReference type="GeneID" id="57024868"/>
    <dbReference type="KEGG" id="lpl:lp_1247"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1058"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_2_9"/>
    <dbReference type="OMA" id="GAYVKRY"/>
    <dbReference type="PhylomeDB" id="F9UN39"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1069-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="44007" checksum="14E9C8824B729CEC" modified="2011-10-19" version="1">MFKRLKDSALLFWSLEILIVATLIWVCTNIGFLFQPIGTFLSVVFMPILISGFLFYMLNPLVKLLTKVHYKKFRISRTGAVAIVFVLLFGLLVWGAVSLLPRLVSQVTQLIYNLPSIATEMQKAATKLINNSSVLKRIDISSYTKQFNGEISKYSQNFLSSLSSSVVTVISTITSVTIMAITIPVVLFYMLKDSEKFIPAISRFLPKKQRPEVIGLLQKMGDTISSYISGQVIECLFVGTFTAIGYMLISQPYGLLLGVIAGLTNIIPYVGPYIGIAPSLIVAFTKSPMQVVYVIIVVVIVQQVDGNLIYPNIIGRTLKIHPLTIIILLLAAGNIAGILGMILAIPFYAVVRTVVIYLYNIVELRNEEHLRKQTTVYQPQPAKATKADLTTTTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN61</accession>
    <name>F9UN61_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,2-diacylglycerol 3-glucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643292.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889164.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1275"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78650">
        <property type="protein sequence ID" value="CCC78650"/>
        <property type="gene ID" value="lp_1275"/>
    </dbReference>
    <dbReference type="GeneID" id="57024891"/>
    <dbReference type="KEGG" id="lpl:lp_1275"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1082"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_9"/>
    <dbReference type="OMA" id="FFCPNAG"/>
    <dbReference type="PhylomeDB" id="F9UN61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1092-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="392" mass="44219" checksum="7918A7E3BFF4A74B" modified="2011-10-19" version="1">MNIGIFTDTYYPQVSGVATSIKVLRNQLERAGHQVYIFTTTDPHVDKNIYERNIFRFTSIPFVSFTDRRIAVRGLFKAYQVAKDLGLDIVHTQTEFSMGMIGKFVAKQLKVPCIHTYHTMYEDYLHYIANGKLLKPYHVKEATRAYCYHLNGIVAPSERVANTLTGYGVKAPIRIIPTGIDINQYEQQSTVDYRQRLGYQSDTPVLLSLSRLAYEKNIHEVIAALPAILEQVPNAQLLIVGDGPARETLENQVQDAGLTAHVQFTGEIDNDEVYNYYQMADLFVSASNSESQGLTYIEAMAAGLKTVVAASPYTDQLLDDPSLGTTFTSETDLIKDVVRYLQHPNTFNDPKPRQKKLYQISAEYFGKQVINYYQDVQLAYSESADKSANISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UND6</accession>
    <name>F9UND6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101378.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1377"/>
    <dbReference type="EnsemblBacteria" id="CCC78725">
        <property type="protein sequence ID" value="CCC78725"/>
        <property type="gene ID" value="lp_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1377"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1156"/>
    <dbReference type="eggNOG" id="COG3551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499477_0_0_9"/>
    <dbReference type="OMA" id="NERAWHR"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1185-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="545" mass="62107" checksum="338197A117DEE323" modified="2011-10-19" version="1">MSQSLWQRLFNHRQQTKQAVLILGSGRSGTSVMTKCVNLMGISLGTDNLLAPSKRINPKGYFENKDVINIHKSLGSRIRYRPAFKDYYDSPKIKKDRAALTTYLRNFFENEQYLAIKDPRMNDYIELWQRVLADVEVQPAEIVLLRNPMDVVNSNERAWHRDTTLAMRQWQVRTLLSLRDTDREHRILVTYEDLFGQTLTTLKRIATQFNLPWTSDEAALQAQIDDFIDPALQKSDSGENLADFEARTDVKPDVKALYLLGRQAAADPDYFASAEFQQRIDEMTDEYLAKYGALYRDFNVKINSKTFFVFGEDQAQVDQVNTTLRNDQVKMVGTEADSHEVAEDLSERLNNNTIAIQTYPLDYLVVEQKEALNNYLRKNAKRETLWGIGDAKNNEIVEMLTTVSAELGADTHNVVIADDLTAITDERERRLAIQHLVRTLHAVEQPPYLVLMADELGTPASQSAVTAFIAAEPTKAAPLRDEQPDETFKLRTPLDMDEVAATLTALCRRASQDEQQQAALNHFVSLNYDEILNVKGDQYANSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI5</accession>
    <name>F9UNI5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, Crp/FNR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101408.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889288.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1442"/>
    <dbReference type="DNASU" id="1062415"/>
    <dbReference type="EnsemblBacteria" id="CCC78774">
        <property type="protein sequence ID" value="CCC78774"/>
        <property type="gene ID" value="lp_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="57025075"/>
    <dbReference type="KEGG" id="lpl:lp_1442"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1207"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_0_9"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="PhylomeDB" id="F9UNI5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1235-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23985" checksum="62C74EF86988B81F" modified="2011-10-19" version="1">MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAKIYALAANGKEKIIELLRSGDVVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGESASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRDCAVESGQIEFELPLKKKELANILGITPETLSRQFKQLAAEGQIIVNKRQITIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK1</accession>
    <name>F9UNK1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101413.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889304.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1460"/>
    <dbReference type="DNASU" id="1062370"/>
    <dbReference type="EnsemblBacteria" id="CCC78790">
        <property type="protein sequence ID" value="CCC78790"/>
        <property type="gene ID" value="lp_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1460"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1223"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098250_0_0_9"/>
    <dbReference type="OMA" id="DPAKHWQ"/>
    <dbReference type="PhylomeDB" id="F9UNK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1251-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027855">
        <property type="entry name" value="DUF4479"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037154">
        <property type="entry name" value="YtpR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14794">
        <property type="entry name" value="DUF4479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23040" checksum="93BC41CB6AA0CBD4" modified="2011-10-19" version="1">MLITSYNPSELGDTLITILRPDTATQTIETHANVTRISDADSGETLGYNFFDVSKTLGDLDANGQVHLTAEQVEQLNNLLKTNDFEPELVLDTDPKFVVGYVESAEAHPKSDHLQITKTNVGLEQPLQIVSGSPNMQANILVVVAKVGAMMPSGLIIWPGELRGVESDGMIVSGRELRLPNAPQRPGALILPADYQPVGAAFDFKRAQTLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS3</accession>
    <name>F9UNS3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644295.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1539"/>
    <dbReference type="EnsemblBacteria" id="CCC78862">
        <property type="protein sequence ID" value="CCC78862"/>
        <property type="gene ID" value="lp_1539"/>
    </dbReference>
    <dbReference type="GeneID" id="57025132"/>
    <dbReference type="KEGG" id="lpl:lp_1539"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1296"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067057_0_0_9"/>
    <dbReference type="OMA" id="TYWEVKV"/>
    <dbReference type="PhylomeDB" id="F9UNS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1323-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394271" evidence="2">
        <location>
            <begin position="32"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="21065" checksum="8079006DEACF8EE7" modified="2011-10-19" version="1">MMSKKYGIGLALLTVVLLAGCGTQQSTQNKATSQSTSSQSNSTKSVTAKTKVSLAAAIKKFQQQYPDASVTSIELEDQLGRPVYTLEGVGGTQEHELQLNGRTGKVISKQSEMLDQDDQADAEGDRLNLNKVISPSKAVAIAIHDRNGGYASELKLDKDNGTTYWEVQVHQGKQQVDIKIDAYEGHILETEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNT5</accession>
    <name>F9UNT5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methylase, SpoU family</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1555"/>
    <dbReference type="EnsemblBacteria" id="CCC78874">
        <property type="protein sequence ID" value="CCC78874"/>
        <property type="gene ID" value="lp_1555"/>
    </dbReference>
    <dbReference type="GeneID" id="57025144"/>
    <dbReference type="KEGG" id="lpl:lp_1555"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1308"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_9"/>
    <dbReference type="PhylomeDB" id="F9UNT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1335-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="27629" checksum="C59DBDC3878183FD" modified="2011-10-19" version="1">MEKINSLQNAHVKAWKKLQTKKGRKQQGQYLLDGWHLVNEAVKAHVAIQTLLITAKQLATEPDLTHFPAVIEISDEVAKHISATVTPQGVFALATLPAAIEDLSQLDLTRPWLLLDNVQDPGNIGTMVRTADAAGFAGVAFGTGTVDIHQPKVERAMQGSQFHLQLISTDLDKLVDQLQAQGSPVYGSELNPQAARYLDIDAPASFGLIMGNEGNGMSRELLARTDQNLYIPIKGQAESLNVAVAAGVLMFGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY3</accession>
    <name>F9UNY3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine betaine/carnitine/choline ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">opuC</name>
        <name evidence="4" type="ordered locus">lp_1609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889436.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1609"/>
    <dbReference type="EnsemblBacteria" id="CCC78922">
        <property type="protein sequence ID" value="CCC78922"/>
        <property type="gene ID" value="lp_1609"/>
    </dbReference>
    <dbReference type="GeneID" id="57025192"/>
    <dbReference type="KEGG" id="lpl:lp_1609"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1357"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_0_9"/>
    <dbReference type="OMA" id="KDPAWKN"/>
    <dbReference type="PhylomeDB" id="F9UNY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1384-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388070" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="311" mass="34805" checksum="8D2DABCFE4D36709" modified="2011-10-19" version="1">MKKIKKWLLGVFATVASALLLAGCGFPGLSGTSSDTIRIASQNTTEQQIMAYMIQDMIKHYSNLNTTIINNLGSGTVSFNALKNDQADISAIRYTGTDLTTILGEKMDRSNIKSIDQKVRSQFNSKYQMTYFPSYGFADTYAFMVTKATAKKYHLNTVSDMKKVASKLTVGLDQIWTERKGDGYPAFKKLYGFQFGKTYPMQIGLVYDALESGKMDAILGYSTDGRIGSYDLKILKDDKNFFPPYNASAVATNKILKAHPKLKPILNRLNGKISLKTMQNLNYQVDNNLVEPEVVAKQFLEKHNYFEGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ3</accession>
    <name>F9UNZ3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pkn1</name>
        <name evidence="11" type="ordered locus">lp_1619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101478.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889446.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1619"/>
    <dbReference type="EnsemblBacteria" id="CCC78932">
        <property type="protein sequence ID" value="CCC78932"/>
        <property type="gene ID" value="lp_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1619"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1367"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_9"/>
    <dbReference type="OMA" id="DPDYRYQ"/>
    <dbReference type="PhylomeDB" id="F9UNZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1394-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="378"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="446"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="513"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="674" mass="74576" checksum="2821782B1BB4D959" modified="2011-10-19" version="1">MTPNYTLSGRYRIVRSLGEGGMANVYLAHDLILDRDVAVKLLRLDLRDDPKTIKRFQREALATTELVHPHIVSLYDIGEENGMQYLVMEYVKGMDLKNYIKENFPLPLQQVIDIMEQILSAVATAHAHNIIHRDLKPQNILIDEQGNAKITDFGIAVALSEHTMTQTNTILGSVHYLSPEQARGSMATKQSDIYSLGIILYEMLTGSVPFKGETAVSIALKHFQNAMPSVREFDADIPQALENVVLQATTKDPRERYATVEDMAADLLTVLASNRAGEKRFVPQDVGNDETKIMPSADIQAAIAANQDGKTQVVAHKSKQPTLQRPAETTESQTDADEEPLPTRSWSKRHPLRRRLLFWGGIILLLVVAVIVGLELSRPQMTTVPKVTGLSQRAATKVLKKHHLTVGTVQHAKSNQVAKNQVIKSTPSVKTRVQERARINLVISNGAKVMSFGNYVNDNYHDVRQTLKSAGFKVKETYSTSSVAAGQIISQDVVAGSRVMPTDTTVTFTVSAGSRYVELKDLTGESKSDILDYAEANDLNVNFKQGYSSEQKAGYSYDQDPDGGGNVRTGSTITVTMSRGSDNNVTTPQNFYVKLTVPYKALSATTAQANDVKIYLYDDTHMIETVYRDIAIMRSTKISLPFQLTGNTKGHYRIVRNGVTIMEKKNITSKSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP02</accession>
    <name>F9UP02_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpA1</name>
        <name evidence="1" type="synonym">acpP</name>
        <name evidence="5" type="ordered locus">lp_1629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889455.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1629"/>
    <dbReference type="EnsemblBacteria" id="CCC78941">
        <property type="protein sequence ID" value="CCC78941"/>
        <property type="gene ID" value="lp_1629"/>
    </dbReference>
    <dbReference type="GeneID" id="57025212"/>
    <dbReference type="GeneID" id="66449511"/>
    <dbReference type="KEGG" id="lpl:lp_1629"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1377"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_9"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="PhylomeDB" id="F9UP02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1404-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="81" mass="9089" checksum="8EADE07D84B89005" modified="2011-10-19" version="1">MTKEEIFDKIADIIADRFEVDKATITNEMNLQTDLDADSIDFVEFVLELEDTFGSEISDEDAEKLSTVGEVVDYVAAHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP13</accession>
    <name>F9UP13_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889466.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78952">
        <property type="protein sequence ID" value="CCC78952"/>
        <property type="gene ID" value="lp_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1642"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1388"/>
    <dbReference type="eggNOG" id="ENOG50349ZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176936_0_0_9"/>
    <dbReference type="OMA" id="DCERKIG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1415-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11811" checksum="5C7C9F0232B7019A" modified="2011-10-19" version="1">MFGCTGKHQVDEQALLSQLVDFVLDTSLTDCERKIGLMAKADLEHHRYSIAVLNKLVVSFQMEALRNKGLSKAASNFYDQIYPILVAAKPMGTNLGYIGMHSTYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP53</accession>
    <name>F9UP53_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, SPFH domain/Band 7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101510.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1690"/>
    <dbReference type="EnsemblBacteria" id="CCC78992">
        <property type="protein sequence ID" value="CCC78992"/>
        <property type="gene ID" value="lp_1690"/>
    </dbReference>
    <dbReference type="GeneID" id="66449560"/>
    <dbReference type="KEGG" id="lpl:lp_1690"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1428"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053998_0_0_9"/>
    <dbReference type="OMA" id="NLMVVLC"/>
    <dbReference type="PhylomeDB" id="F9UP53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1455-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="56"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="31676" checksum="1DD4E76FEC73BE0E" modified="2011-10-19" version="1">MKEKQVFHINGYIGLVLAIAFVLVGGWLVWAGATGDHFASIFLGALLIIIAAFGASSLTIVGPNEARVLTFFGKYIGTIRDSGLFMTVPLTSKFSISLRVRNFNSAILKVNDLRGNPVEIAAVIVFKVVDTSMALFAVDDYEQFVEIQSESAVRHVASEYPYDTFDDDKKITLRSNPTEVSDRLTEELQERLNVAGVEIVETRLTHLAYATEIASAMLQRQQSSAILSARKVIVEGAVSITEDTIARLEKDTGMQLSDDKKLQLINNMMVTIISERGTQPIVNTSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP66</accession>
    <name>F9UP66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889519.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1703"/>
    <dbReference type="EnsemblBacteria" id="CCC79005">
        <property type="protein sequence ID" value="CCC79005"/>
        <property type="gene ID" value="lp_1703"/>
    </dbReference>
    <dbReference type="GeneID" id="57025335"/>
    <dbReference type="KEGG" id="lpl:lp_1703"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1439"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_0_9"/>
    <dbReference type="OMA" id="DEDTYCT"/>
    <dbReference type="PhylomeDB" id="F9UP66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1468-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="32322" checksum="F6EC0768C0F9AC7A" modified="2011-10-19" version="1">MATTYGIFYNGQAGNGQAATVAHQTAQALSNHGIESQLLTTPGIPRAIALIKQTLPQLSALIVIGGDGTLNVAMTALIQAEAHIRIGVIPMGTVNNFATRYQLPTDPQAAIELICTQPATQAVGMLVCNQRRAVVSSLTFGNLADISNEVRQSEKQRFGKLSYLYRAIRHIGHNKSLPIRYQFKHEGSHTLKTWFCLITTTKSVGGHVYSASAPGKMHISLLNNIGWRQVIPYFWFALTGNLQNSKAITQLTATSARITSATGQAVTTRIDGDPAVKLPIELTYLTDRFELIVPAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA9</accession>
    <name>F9UPA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644375.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1756"/>
    <dbReference type="EnsemblBacteria" id="CCC79048">
        <property type="protein sequence ID" value="CCC79048"/>
        <property type="gene ID" value="lp_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1756"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1481"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_3_1_9"/>
    <dbReference type="OMA" id="GFMYKAN"/>
    <dbReference type="PhylomeDB" id="F9UPA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1512-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="381" mass="43112" checksum="2D7186D6E6D5025C" modified="2011-10-19" version="1">MQEFRLIATAASGIEALVGRELRDLGYQVQTENGRVRFNGTIKDILRTNLWLRTADRIKIIVGEFDAYTFDELFEKTLALPWDQLLPMDAEFPVEGKSRNSKLHSVPDVQSIVKKAIVNQLADTYHRSGHLPETGALFPLEVAINKDHVLLTLDTTGSSLFKRGYRVEKGGAPLKENMAAALVMLAKWYPDNPFVDPVCGSGTIPIEAALLARNIAPGFNRAFACEKWDWVPAGLSQQLRDEADSLADYDTELDISGYDIDGKMIDIAKLNAREAGLLHDIHFKQLAVKDFTTDKINGVLIANPPYGERLSDRDSVRILYRQMGQVYSKLPSWSKYILTSDLEFEDFYGQKATKRRKLYNGALRTDYFQYWGKRIRPARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB8</accession>
    <name>F9UPB8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase, family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101542.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889571.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1767"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79057">
        <property type="protein sequence ID" value="CCC79057"/>
        <property type="gene ID" value="lp_1767"/>
    </dbReference>
    <dbReference type="GeneID" id="57025383"/>
    <dbReference type="KEGG" id="lpl:lp_1767"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1491"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032550_0_0_9"/>
    <dbReference type="OMA" id="ISANTQY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1520-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044081">
        <property type="entry name" value="DUF5776"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19087">
        <property type="entry name" value="DUF5776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394284" evidence="2">
        <location>
            <begin position="29"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5776" evidence="3">
        <location>
            <begin position="375"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="447" mass="50032" checksum="921D47C95B28E4C1" modified="2011-10-19" version="1">MVMQKKWRLILLLVGCFLGGIGVVQAHAAVPDISEWQGQLTSTEVQSLKSQADFVINRVQYGSSYEDLYHTSNESLYVKYGVPFGSYDYATFTSTATAKAEADKFYQRANKNTKFYVLDFETTSMSSTAANAAVKAWYTEMRSLTSKKLIFYSYQSFATTYANTARQSFDAQWIANYSSKPTISFSLWQYSSSYYLSSLGQYVDNSLYDSASVTTYHPLSWWTSGTSASSSTSSTSTTYAYSSYTKGQHVYLNNGASSYYDGTKVPSSAKKKYYKVTATKSVTKSRSKQLVYLSGLNKWVLSQDVTGYWVGQHGLYQLREKSTLFKDVNLTTSTGKTLKKGGIYSGKLVKSGNFYRIKVSGGYITAKVSKSDHWYYESVPSSGWIKAKVGLYTYKSSNFVKSNRHAYHAAGDRIKVTKVYSRSGGSRYYLTNKGNYVSANRSNVVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC5</accession>
    <name>F9UPC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H-like family protein</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1777"/>
    <dbReference type="EnsemblBacteria" id="CCC79064">
        <property type="protein sequence ID" value="CCC79064"/>
        <property type="gene ID" value="lp_1777"/>
    </dbReference>
    <dbReference type="GeneID" id="57025390"/>
    <dbReference type="GeneID" id="66449625"/>
    <dbReference type="KEGG" id="lpl:lp_1777"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1498"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095977_2_0_9"/>
    <dbReference type="OMA" id="QWLPEKE"/>
    <dbReference type="PhylomeDB" id="F9UPC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1527-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14063" checksum="D01809026023396A" modified="2011-10-19" version="1">MQLYTDAATTPDNQRSAAGILIIDQGQQHQFKQVLPDSDNHTAEFLAAIAGFKTLLDSYGPQVSVFFYTDSQIVAESVAKGYSKTFSVELATLLHLQDQCQLVITQWIAESDNHGAHQLAQQGLHLSD</sequence>
</entry>
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            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
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    <gene>
        <name evidence="1" type="primary">pgm5</name>
        <name evidence="1" type="ordered locus">lp_1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101549.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1785"/>
    <dbReference type="EnsemblBacteria" id="CCC79072">
        <property type="protein sequence ID" value="CCC79072"/>
        <property type="gene ID" value="lp_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1785"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1506"/>
    <dbReference type="eggNOG" id="COG0406">
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    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="SHAGAIF"/>
    <dbReference type="PhylomeDB" id="F9UPD3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1535-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53254"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="199" mass="22590" checksum="ED55F9BAD503F432" modified="2011-10-19" version="1">MAKTLYMMRHGETLFNRLKKIQGACDSPLTPKGIADAQRVGAYFQAQGITFDHAYSSTQERASDTLELVTKQPYERLKGIKEWNFGVFEGESEVLNPKPDPVRRSHGDFFCQYGGESDLQVQDRVVKTLTAVMARPDHHQVLVVSHGGASFMFLRQWLSMDEIERQGIVLHNCAVIKYQYDAGRFTFEKIINLAATDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ2</accession>
    <name>F9UPJ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin monooxygenase, luciferase-like monooxygenase family</fullName>
            <ecNumber evidence="2">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1860"/>
    <dbReference type="EnsemblBacteria" id="CCC79131">
        <property type="protein sequence ID" value="CCC79131"/>
        <property type="gene ID" value="lp_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1860"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1568"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_8_0_9"/>
    <dbReference type="OMA" id="LEHHFTE"/>
    <dbReference type="PhylomeDB" id="F9UPJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1593-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="352" mass="38866" checksum="91F3574DA9355C68" modified="2011-10-19" version="1">MIDVNQLEFGLETFGDIVANADGSLQSAGESLRQIVREGQLADQYGLDVFGIGEHHRPDYSVSSPETVLAATAAVTQHIKLASAVTVLSSDDPVRVYERFATLDGLSNGRAQVMLGRGSFTESFPLFGYDLTDYDDLFNEKLALYDQLRTEKPVTWSGKFRASLTNQDVYPKTATGELETYIGIGGSPESIIRAAKIGYKVIIAIIGGRADRFKPYIKLYHEAAKKFNQPAYPIAVHSHGFIADDQDEALTVAYQNIKANFDRIGLTRGWAPMSHEQFDRETKYGSFYVGTPTVVAQRIAMTIETLGLGRFDLVYGAGNQTAAQRERMIELYATQVIPQVKTILQAKQVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN8</accession>
    <name>F9UPN8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889691.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79177">
        <property type="protein sequence ID" value="CCC79177"/>
        <property type="gene ID" value="lp_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1915"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1614"/>
    <dbReference type="eggNOG" id="ENOG50309Q7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725201_0_0_9"/>
    <dbReference type="OMA" id="YDSYERS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1639-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394287" evidence="1">
        <location>
            <begin position="25"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="381" mass="41586" checksum="7FCEDF851E71F454" modified="2011-10-19" version="1">MHKLAILVMTIGLALAGCTTQTFAPVKHHRSVKATTQKVIQAPTKTWTFDQAVSSSQTKHGVASNLDISVVDKTTAQSSWTTSNGQFLSAGVKHRQVSYAKWHHDQQRHIMKSYRHRLHHMSVSQINAVLKKLGASIQINKLTDLIYLESGNHTDPLPVNTAFAAKGHHLYAVNIQYSDTEQATTIERGCDFTDTSAKAAPKRVNVANLNGTWIAAETTTSASDTGKLLIKDGYLYQHRYDSYERSAIQDLSHYSLGSLNQNVAYAAFKTDAAHAGYQLTHTAVASGDSTGMLYLIINANKIIRINQQIVTTYTKTSAVVAANDLPKTDVDLFKQMDQKKAGEVATTITVKAGPAQVGMTNSINYLTDPNAGQITETIVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP7</accession>
    <name>F9UPP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101595.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889700.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1926"/>
    <dbReference type="DNASU" id="1064093"/>
    <dbReference type="EnsemblBacteria" id="CCC79186">
        <property type="protein sequence ID" value="CCC79186"/>
        <property type="gene ID" value="lp_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1926"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1623"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_2_0_9"/>
    <dbReference type="OMA" id="CNSWSLE"/>
    <dbReference type="PhylomeDB" id="F9UPP7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1648-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="28013" checksum="1F28351E24B6EA0B" modified="2011-10-19" version="1">MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPNTFNKLDQYLDRDDDLLQTKRALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIVTNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILALHKFRFTTTVLSCAGLTADGVYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLATKIAPDKLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS2</accession>
    <name>F9UPS2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889725.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1955"/>
    <dbReference type="EnsemblBacteria" id="CCC79211">
        <property type="protein sequence ID" value="CCC79211"/>
        <property type="gene ID" value="lp_1955"/>
    </dbReference>
    <dbReference type="GeneID" id="57025536"/>
    <dbReference type="KEGG" id="lpl:lp_1955"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1651"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="MKQEYYK"/>
    <dbReference type="PhylomeDB" id="F9UPS2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1675-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
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        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="28882" checksum="FD35B470F44F8C72" modified="2011-10-19" version="1">MFTLLRQENRKLMHYRVIQLFIPFIMIFQFIIAIYAAHYPQLLTPYDAFVNNDYGFIPILFLTITIGSTYLTNERQNGTLRALLYRSYSRTQVLVSKWLTILGLMIGLSGFSTLMSLGLKLSFFRRLPNYGTIWHTWGLNMLSTGLTLLFLMSVVLLLGTLFTSSTPAILTGIIGYFIVTIFNQLCFYLYAKVSWLKWNPLNMINLGEQIQTPQLQQLTRLNLSTLTIGYIAYLLLFLTLANYSFQTRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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    <name>F9UPU2_LACPL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1978"/>
    <dbReference type="EnsemblBacteria" id="CCC79231">
        <property type="protein sequence ID" value="CCC79231"/>
        <property type="gene ID" value="lp_1978"/>
    </dbReference>
    <dbReference type="GeneID" id="57025556"/>
    <dbReference type="GeneID" id="66449783"/>
    <dbReference type="KEGG" id="lpl:lp_1978"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1671"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DUF2179"/>
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        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Membrane_protein_YitT"/>
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    </dbReference>
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        <location>
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            <end position="40"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="108"/>
        </location>
    </feature>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
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            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="291" mass="32076" checksum="CAE4CCDFE8DF7BB5" modified="2011-10-19" version="1">MDDFQQLSKHHRDVVKASTAFIYAILVSIAMNYFWTPGHIYSSGITGLAQLINSLMSKFLPVQISTAALLFILNVPMFIIAWRSIGHKFTLYTFLAVTLSSIMIKLIAPVGLTHDPIICAIFGGAVNGFGTGTALKNGISTGGLDIIGIVLRRKTGRSIGTINMAFNSIIVIAAGFVYGWPYAFYSALGLFVNGRVMDMTYTRQQKMQVMIITSRPKTVIDSVQNRIRRGVTIVHNAEGAYQHDDKTILFTVITRYEMGELKAAMAESDPHAFVSISDTVKILGHFYEPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ57</accession>
    <name>F9UQ57_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Glutamine ABC transporter, ATP-binding protein</fullName>
        </submittedName>
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        <name evidence="5" type="primary">glnQ3</name>
        <name evidence="5" type="ordered locus">lp_2110</name>
    </gene>
    <organism evidence="5 6">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889860.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2110"/>
    <dbReference type="EnsemblBacteria" id="CCC79346">
        <property type="protein sequence ID" value="CCC79346"/>
        <property type="gene ID" value="lp_2110"/>
    </dbReference>
    <dbReference type="GeneID" id="57025653"/>
    <dbReference type="GeneID" id="66449881"/>
    <dbReference type="KEGG" id="lpl:lp_2110"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1787"/>
    <dbReference type="eggNOG" id="COG1126">
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    <dbReference type="OMA" id="APIWVRR"/>
    <dbReference type="PhylomeDB" id="F9UQ57"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1807-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="26947" checksum="676AF49317F5FE56" modified="2011-10-19" version="1">MTKPVIEVKDLAKSFGENDVLKDITEKVEPGQVIVVIGPSGGGKSTFLRCLNLLETPTSGQVAFEGQDLTTLDTKSVNALREKMGMVFQGFNLFPNMTVLENIKLAPMKVKHVDDAAATKQAHELLQRVGLDDHADAFPSSLSGGQAQRVAIARALAMNPEVMLFDEPTSALDPEMVGEVLNVMQELAKDGMTMVVVTHEMGFAKSVADRIWFMADGYIQENNTPEEFFANPQTERAQDFLSKILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ87</accession>
    <name>F9UQ87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1(Or 4)-monophosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">suhB</name>
        <name evidence="3" type="ordered locus">lp_2147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640819.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889890.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2147"/>
    <dbReference type="EnsemblBacteria" id="CCC79376">
        <property type="protein sequence ID" value="CCC79376"/>
        <property type="gene ID" value="lp_2147"/>
    </dbReference>
    <dbReference type="GeneID" id="57025682"/>
    <dbReference type="KEGG" id="lpl:lp_2147"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1817"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_6_2_9"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="PhylomeDB" id="F9UQ87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1837-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="27711" checksum="3D8E38A7FEAE22D6" modified="2011-10-19" version="1">MQTNVVKQLNQKMQVVMQTARAQVLAKMGTHLTVAEKTSRRDLVTNVDHSNEDFLVRQIRALDPVAKILAEEGTGDQVTDMNGHVWIVDPIDGTMNFVHQRNHFAMMVGLYVDGKPTLGYIFDVMANKLYAGGPEVGVTLNGELLAAPADVDLSAGLFGASAPLLIQDRFNMQTIIAKSLGPRIMGSAGIQISQVLAGELVGYLSYLRPWDFAAGRVLAESLGLVVSRVDGNPVNMLSSGAVLIATKRAQRSILAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA5</accession>
    <name>F9UQA5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgm6</name>
        <name evidence="1" type="ordered locus">lp_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889908.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2170"/>
    <dbReference type="EnsemblBacteria" id="CCC79394">
        <property type="protein sequence ID" value="CCC79394"/>
        <property type="gene ID" value="lp_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2170"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1835"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="TRHGKTE"/>
    <dbReference type="PhylomeDB" id="F9UQA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1855-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="24957" checksum="27DF75BE8A2DEEC9" modified="2011-10-19" version="1">MTKLLFVRHGKTEWNLEGRYQGSQGDSPLLPTSYQEIHELAAALQDIRFSHIYVSPLKRARDTAMTLRNDLTQSELPITVLSRLREFNLGKMEGMAFTDVEATYPAEFDAFRNHPDQYDPTAIQGESFQQLLKRMTPAIKQIVQANPRRDDNVLIVSHGAALNALVNSLLGATLATLRQRGGLSNTSTTILETRDRGQHFKLLDWNDTSYLSRRPDATDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF4</accession>
    <name>F9UQF4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UQF4"/>
    <dbReference type="STRING" id="220668.lp_2230"/>
    <dbReference type="DNASU" id="1061248"/>
    <dbReference type="EnsemblBacteria" id="CCC79443">
        <property type="protein sequence ID" value="CCC79443"/>
        <property type="gene ID" value="lp_2230"/>
    </dbReference>
    <dbReference type="GeneID" id="57025753"/>
    <dbReference type="KEGG" id="lpl:lp_2230"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1885"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135091_0_0_9"/>
    <dbReference type="OMA" id="QTSNDYY"/>
    <dbReference type="PhylomeDB" id="F9UQF4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1904-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="71"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="19250" checksum="9742C21FEC420109" modified="2011-10-19" version="1">MSGKIAATFGTRKILTMIQQQNADRDLLLMQANATEDRYMLLDLTGEKTVFSSPVTYDVLLSKGSADWHGMTSFIFIDLPEEEQKVFKSKFSSFRHDYNKPDGLKHFWILRESKNNSAFVIVTNWHSDSEYAVWLRSASFKPFAKYITSDYGYHESRYSFVRSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQK6</accession>
    <name>F9UQK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2290"/>
    <dbReference type="EnsemblBacteria" id="CCC79495">
        <property type="protein sequence ID" value="CCC79495"/>
        <property type="gene ID" value="lp_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2290"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1938"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008413_1_0_9"/>
    <dbReference type="OMA" id="NNFYFAY"/>
    <dbReference type="PhylomeDB" id="F9UQK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1979-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114855" checksum="E58692F4F1A8D60A" modified="2011-10-19" version="1">MKTVRKIPLVVWYTAMFVVIATITYSGLFLAGRTLIWEVDGIAQHFPILLEFQRILQHHPQQLFSWSWNLGLGADQLTTFSYYVVGDPFNYLVAFVSRAHLEWAYQALILLRLYFVGLAFLGFSRQFKFKRVSQLIGALTYTFTAYTFYVGMHHPFFLLPMIWFPLLCWAIERVLRGRHWLPLSLITAVVILSNFYFAYLLALGGLVYALVRFWSRRRDHLTMRSFGQLFWRLLVAVGLGVTMAGILLVPTLLAMLTATRASFNFANGLTSYPINYYVNLPNRLLTNGGSVQYWVTLGLSSISFIAIIYTLRHFRRYWVLNWVLVVMMLGILLPQFAAVFNVFSTPSNRWLLMATLVFAYATMAFMDQVTALTAADLKWLAGISGGLLVIIWLINGFYLNIRKHDIATYLILLALIGVLLVKQSLKLTNRQFYVLLLGIVTLNLANNGLGWLSINTNSNSTEQLRQGAAMKWVKNYFDGAQKSLTTTSQFYRTALAPNYYTMRSAESDVPMVLGTHTVGSYFSVQNGYVGAFSQALGNSEYAMNSPLGSLDGRTTMYNLLGVKYLFAREDQLKKQALPAGYEVVKMKTGEPKIFADKFIYGMSNHTGTILLKSKNALPLVYTQQHQISQRQFNRLNAVDREQALLQGAVTTQQVSGVKTVKPTVTGKNVAYTVQADTTNVLDTLDKVIIYRNQHATGASNNALTKLPADTITLTPEQRESLTPATGLTTPSNRVLNLIAANQKLVQKNQENNADELTSMVSDVQGHQIPYQLTIQHPKKYRNTELYLVLDGISYRRSSIKHALTTSQNINVFTARPYTKVDYLDDVRDGLKGNLSASGYSLTAQTTDNLTSFSQLGTTNMSDYEPRTSAVINLGYSKYARKLITLNFTSIRSLHFKSAKLIAVPLGKTYRQRTRQLQTSGLKHQQVTNNQITGTTLTKTATVLTTSIPYSTGWQLRVDGQTVRTQVVNKGFVGAKLTAGRHQIRLTYHTPGLKIGIWSSIIGGVISILIACWWGLHKRVRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM8</accession>
    <name>F9UQM8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FormylTHF-polyglutamate synthase / folyl-polyglutamate synthase / hydrofolate synthase</fullName>
            <ecNumber evidence="5">6.3.2.12</ecNumber>
            <ecNumber evidence="5">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folC1</name>
        <name evidence="5" type="ordered locus">lp_2321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="5"/>
    <dbReference type="EC" id="6.3.2.17" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101711.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2321"/>
    <dbReference type="EnsemblBacteria" id="CCC79517">
        <property type="protein sequence ID" value="CCC79517"/>
        <property type="gene ID" value="lp_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2321"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1962"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_9"/>
    <dbReference type="OMA" id="KCDYAVI"/>
    <dbReference type="PhylomeDB" id="F9UQM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2001-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="46"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="444" mass="48512" checksum="2D338D89A803C9F4" modified="2011-10-19" version="1">MIDTYSAALAFIHGRTQFKKAPTLSRMRQFLHELGDPQLKVAGIHVAGTNGKGSTVANLRELFMADGLTVGTFTSPFIVRFNERISVDGTPISDEELVGLVQQIQPIVAKLDATLASGGPTEFEIITAMMFLYFAAQPIDIAIIEVGLGGLYDSTNVWTPAVSVITTIGYDHMQILGNTLTAIATQKAGIIKTQVPVIVGKLPAEAQQVMIDTTMSKRAPLRTLGVDFTTKLLPPQGWQERFNFDGLEAHFKDLTTPLLGDYQVDNAAVAIAAYLTYHQATQLPVVTSDVKTAVAATQWPGRFERLNQDPLIMIDGAHNEPAVTELAATLSERFGQQIVYVIFAVLADKQHQQMIQTLGALPNVQLRLTQFEGPNAKRPATDPTMLAHEMPNGRTAEVFDNWQAALMQTLQEMSSDDALLLTGSLYFISDVRAYFKDGSDLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT7</accession>
    <name>F9UQT7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, DUF 1093 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101730.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2396"/>
    <dbReference type="DNASU" id="1062443"/>
    <dbReference type="EnsemblBacteria" id="CCC79576">
        <property type="protein sequence ID" value="CCC79576"/>
        <property type="gene ID" value="lp_2396"/>
    </dbReference>
    <dbReference type="GeneID" id="57025920"/>
    <dbReference type="KEGG" id="lpl:lp_2396"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2021"/>
    <dbReference type="eggNOG" id="COG5294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126418_3_2_9"/>
    <dbReference type="OMA" id="IMMISVG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2061-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006542">
        <property type="entry name" value="DUF1093"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036166">
        <property type="entry name" value="YxeA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36433">
        <property type="entry name" value="PTHR36433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06486">
        <property type="entry name" value="DUF1093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159121">
        <property type="entry name" value="SSF159121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01655">
        <property type="entry name" value="yxeA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="14750" checksum="F30838E420D1418C" modified="2011-10-19" version="1">MNKKWAVWLVAIIMMISVGTLLIVPTMTKNQGSELAMAVDNLNPFVKVQTVYGRTNQAIGHSTGQMGEDIYTYRMLTSDAQGKQRWLTFTADHRLKQRHYLKIETKGQNVNSWEAVVTNQVPQNIQEVLA</sequence>
</entry>
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    <accession>F9UQV3</accession>
    <name>F9UQV3_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Prophage P2a protein 44</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2413"/>
    <dbReference type="EnsemblBacteria" id="CCC79592">
        <property type="protein sequence ID" value="CCC79592"/>
        <property type="gene ID" value="lp_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2413"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2039"/>
    <dbReference type="eggNOG" id="ENOG5030AJS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1956807_0_0_9"/>
    <dbReference type="OMA" id="QNEPRSY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2077-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14594" checksum="6E463C114D0058A4" modified="2011-10-19" version="1">MSPEEDLLLNVKKCLRAFNVPVYDFGQQRPTKFPQVVVSLQNEQEQTDIKVLDYFLATVAVDVYADVANVGQAYALGRKVANAMQRLELTEWPSKYDSSSMHKLIDNSLEGRPLTRLAYLFDIFVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW0</accession>
    <name>F9UQW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 37 portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101752.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2420"/>
    <dbReference type="EnsemblBacteria" id="CCC79599">
        <property type="protein sequence ID" value="CCC79599"/>
        <property type="gene ID" value="lp_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2420"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2046"/>
    <dbReference type="eggNOG" id="ENOG502Z7Z6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034083_1_0_9"/>
    <dbReference type="OMA" id="WANNDEY"/>
    <dbReference type="PhylomeDB" id="F9UQW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2084-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006428">
        <property type="entry name" value="Portal_SPP1-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01538">
        <property type="entry name" value="portal_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="550" mass="61966" checksum="DEA81690925B0BC2" modified="2011-10-19" version="1">MIINNIYGKQRFDREANRDYTMPVGTYTAVSEQPLELMKIVYQFINHHQNHQVSRLQTLYDYYQANNAIKKQGDSDNPYHANNRVAAAFARYMTSIRVGYLIGNPIQLKLQDDTGVDDSHAQKFQNVLDTFITNTNADYVNQQLAKDLSITGRAYDLVYVKNGVTDLGLVRVDPEQAFVIYDDTVDHKPLIGVRYYQTGILDNQLVEHYEVYTDSRLFTFHSQGGLPQTNSPVANAVLDDTLPHFFGIVPLTEYRNNDERLGDWEPELDQLDALDKSVSMMADFQEDFNNANIVLTGKFSNMTEPKYLLDENGTKKIGQDGQPIIIEPAHPNVDPKNHMWYLEPFAASGGVGSTAKHIIQPDAKYLTKQYDAAGWSTYTNFLINEIHKYTNTPNVNDPNFASNASGVAMSYKLWGSDQERKLQETLFKRGLHARLNACVNYWQTLNQISPDKWNTMIKANFMPNLPKNDDATAQLITLLNGTGKFSDETIRDMAEPITGINADTEAERIKKGIHDAKEDEDNYAQGGGGLGNIFATGEKASLPDNNNKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW6</accession>
    <name>F9UQW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 31 phage transcription regulator, ArpU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2426</name>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
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                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Ursing B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
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                <person name="Nierop Groot M.N."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <property type="gene ID" value="lp_2529"/>
    </dbReference>
    <dbReference type="GeneID" id="57025957"/>
    <dbReference type="KEGG" id="lpl:lp_2529"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2128"/>
    <dbReference type="eggNOG" id="ENOG5030B69">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2130319_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2185-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="113" mass="12093" checksum="E97909BF4BE74EF6" modified="2011-10-19" version="1">MIDEVLVLNSTPTGILQNSVSGSMVIDAALDARLVKRLMQALTQSMLKVRVATADDLPVTDHQLLVVSRPVAAVLDLQASARVLIYPEATGLTAAGMTQLAVQIDQRLTKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB2</accession>
    <name>F9URB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2604"/>
    <dbReference type="EnsemblBacteria" id="CCC79751">
        <property type="protein sequence ID" value="CCC79751"/>
        <property type="gene ID" value="lp_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2604"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2187"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_0_9"/>
    <dbReference type="OMA" id="RHIQEAN"/>
    <dbReference type="PhylomeDB" id="F9URB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2242-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35574" checksum="3F36409BEE6039D5" modified="2011-10-19" version="1">MRLGILGTGKIVQDFLPMVKSIPAIELVGLLSTPRSVARARELQATYRIGTVYTDYAALLADTTIDTVYVALPNSLHYDYAKRALQAGKNVICEKPFTLVASQLTELIELAGRQDLVLIEAITNQYLENYQVIKRDLTKLGDLKIIECNYSQYSSRYDQFKAGTILPAFNPKLGGGALMDLNIYNIHFVVGLLGAPTHVQYLANVERNIDTSGILVLTYPNVKVVCIGAKDSTSPVRSTIQGTTGSIIVNGPTNTVESITEIAHDGTTTDLTLNQAEHRMYAEFVAFERLIANHDMVTVKRQLDHSQAVMEVVDQALASAGLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB3</accession>
    <name>F9URB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2606"/>
    <dbReference type="EnsemblBacteria" id="CCC79752">
        <property type="protein sequence ID" value="CCC79752"/>
        <property type="gene ID" value="lp_2606"/>
    </dbReference>
    <dbReference type="GeneID" id="57026013"/>
    <dbReference type="KEGG" id="lpl:lp_2606"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2189"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_0_9"/>
    <dbReference type="OMA" id="VAHIYRR"/>
    <dbReference type="PhylomeDB" id="F9URB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2243-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="39126" checksum="49080CD84E97D7A9" modified="2011-10-19" version="1">MLTIAYIGNGKSANRYHLPFALKLKDQIKVKTIYSRSGRQNWQPIADVHYTTTLADIYEDPDIQLVVVSTPSHTHYSVAKDVLNHGKNVLVEKPFTETSAEARELFELAKQKHLFIQCYQNRRFDSDYLTTQKVIESGVLGDLLEVEMHFDYFRPEVPTNVDHFSLDTSYLYGHACHTLDQVIAYFGEPDDVHYDVRQLLGSDRMNDYFDIDLYYGALKVSVKSSYFRIKSRPSFVVYGKKGMFVKATKDRQEYDLKHFYMPNHADFGIDQPENYGTLTYIDDAGQYHEEAVVSEVGDYSRVYAGVYDSIINGQPKLVKDEETLLQVKMLETGIQQCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD8</accession>
    <name>F9URD8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lplA1</name>
        <name evidence="9" type="ordered locus">lp_2643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890291.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2643"/>
    <dbReference type="EnsemblBacteria" id="CCC79777">
        <property type="protein sequence ID" value="CCC79777"/>
        <property type="gene ID" value="lp_2643"/>
    </dbReference>
    <dbReference type="GeneID" id="57026037"/>
    <dbReference type="KEGG" id="lpl:lp_2643"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2215"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_9"/>
    <dbReference type="OMA" id="RTCPEDD"/>
    <dbReference type="PhylomeDB" id="F9URD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2268-MON"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="38176" checksum="9A4BB8B956E3BC5D" modified="2011-10-19" version="1">MYYVAMKDHEIGRNLATEQYLMNNVDFDEPLVLFYYEEPCIIVGRNQNTLEEINADYVREHHITVTRRLSGGGAVYQDLGNLCFSFVVDSDSQEFGDFKTFTKPIIDALHDMGATTATVSGRNDLLVDGKKFSGNAMYSRNGKTFSHGTLMLNVDLNVVPQALTVPTDKIASKGIKSVRSRVTNLRPYLAPEYQNITVPEFQDALLKELFHVDSLDQIADKEYHVTPEQQKAIDKIYEDYYANWDWVYGKSPEFSVKRRQHFDMGTIDARISVDDGLINNIKFYGDFFGSGNVQDIEAALKGVRYDHEAIAKALADIDLNQYFTGIERSAVIDLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG2</accession>
    <name>F9URG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP3</name>
        <name evidence="8" type="ordered locus">lp_2674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101877.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2674"/>
    <dbReference type="EnsemblBacteria" id="CCC79801">
        <property type="protein sequence ID" value="CCC79801"/>
        <property type="gene ID" value="lp_2674"/>
    </dbReference>
    <dbReference type="GeneID" id="57026062"/>
    <dbReference type="KEGG" id="lpl:lp_2674"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2240"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_6_4_9"/>
    <dbReference type="PhylomeDB" id="F9URG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2292-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="530" mass="58918" checksum="95E6BB136FF96198" modified="2011-10-19" version="1">MNLMVSSFILVLAAVVSIFISRVMPQISVNYLSLIVGIGLFFIPVLSNHIENFNSEIFIGLIVAPLLFFEGQATRLNAVGKELKHIIQTTVGLVILALIVAGFSLAGLGLVGLPLAFILAAISTPTDATAMESVTNGLEMPSTEGTFLKMESLFNDASGIILLNMAVLWYANGYINYGQTIIDFIISAVGGVLFGFVSAWIMVLFRQVLLRSSYNSLNASLLMYVITPFILYYAAEAIHVSGIITVVVAGLVHNAEAQRSRLINAQQVHFAFDLVSMITEIFNSMVFVVLGFMFIKILVNEQFGHGSLNFLLIGLVLYISNVLVRYSYGRLRLSFKNRPAWIFALGGVHGAVTLALAYTLTDTAVGRGDFNLVLMAASTLIILSMVVPTIIFRWLLKPALTDDEATSEIDQIRVAMVHHAIDTVQKMYLPPNVKESVIFDLMTQKQRTRTRDFARAWVDVVRRPEFTGAEKELEMRAFMNALEQERQYLDMISQREVKYQKYVFKLYNETLLAESLVIGPTIFDKDKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL1</accession>
    <name>F9URL1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface hydrolase, DUF915 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101900.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890364.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2737"/>
    <dbReference type="EnsemblBacteria" id="CCC79850">
        <property type="protein sequence ID" value="CCC79850"/>
        <property type="gene ID" value="lp_2737"/>
    </dbReference>
    <dbReference type="GeneID" id="57026110"/>
    <dbReference type="KEGG" id="lpl:lp_2737"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2290"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9URL1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2341-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="269" mass="29668" checksum="1590CB22A7DDA647" modified="2011-10-19" version="1">MPKKVIWGLIASGLFLLLIVGLGLTTQIHQDKVSHVITAQKRPLIMIGGSSSTRTDFDDIVRSLNEQQHHPLITLTVKANQKLAFKEKRVENTNLNDALIVIFFEDSTDSTENIMTQTNGLAKAIRYLQRHQHLTTANALGYSNGGLIWSRYLAGLSSSKPLAVHDLMLIGTPFLGTDAAHPDKTLYTPLLDHKNQFKKLHAVINIAGDTGEGNDDIVPLSSVNAGGNLFMNNVTRYTAMTVNQKSISHGDLLHEAYVARLIRQNLINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU2</accession>
    <name>F9URU2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890445.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2839"/>
    <dbReference type="EnsemblBacteria" id="CCC79931">
        <property type="protein sequence ID" value="CCC79931"/>
        <property type="gene ID" value="lp_2839"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2839"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2373"/>
    <dbReference type="eggNOG" id="ENOG50309VR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096771_1_0_9"/>
    <dbReference type="OMA" id="HIGFTID"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2428-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032083">
        <property type="entry name" value="DUF4811"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16069">
        <property type="entry name" value="DUF4811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18281" checksum="3A0649DD4E8949E3" modified="2011-10-19" version="1">MIIVLLILATLVFAGTMIFSPAGRNRLIAIIISGLIIAASLIALVLNDNYHWGMHEVTRTQIQDLAPLKSKQAALRVQQLGTGSERVISYRVAAATKVSHTVTATTTTTKLTSGSPAQVQLKTTTWQFKNHLTHVLFSLGNTKTKIVQRQYLFTIPKTWQVVTVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW0</accession>
    <name>F9URW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, ATP-binding protein,N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2858"/>
    <dbReference type="EnsemblBacteria" id="CCC79949">
        <property type="protein sequence ID" value="CCC79949"/>
        <property type="gene ID" value="lp_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2858"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_15_9"/>
    <dbReference type="OMA" id="ENMFTEP"/>
    <dbReference type="PhylomeDB" id="F9URW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2446-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="78" mass="8194" checksum="EEB40B2C778BAB28" modified="2011-10-19" version="1">MAYIEVQQATRQFKNGEQVTVANRDISFEVDQGAVVVILGPSGAGKSTLLNILGGMDSPTSGRVRFSILQPGSELDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ2</accession>
    <name>F9URZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101961.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890495.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79981">
        <property type="protein sequence ID" value="CCC79981"/>
        <property type="gene ID" value="lp_2900"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2900"/>
    <dbReference type="HOGENOM" id="CLU_1473427_0_0_9"/>
    <dbReference type="OMA" id="YTSQANI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2477-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20459" checksum="C0B18BFBF911C93D" modified="2011-10-19" version="1">MNYTSQANIHKFTLVIILLSSILISTTITLEISANTTSSSQQAIDCISQELADVSNSIRYDPQTGLATNLDVNALVSKYGSNNQNQLQHINEIMKYEYKRNLQFNQGKLNSIQTRSFWSCMKNQLLDMIGYQTFQALLRGGIQGLIQRKAWKAAAKLLIRYLGDGIGVGFIAAQLAWYAIRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9US51</accession>
    <name>F9US51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-P adenylyltransferase, regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgD</name>
        <name evidence="3" type="ordered locus">lp_0022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641646.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888112.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US51"/>
    <dbReference type="STRING" id="220668.lp_0022"/>
    <dbReference type="EnsemblBacteria" id="CCC77598">
        <property type="protein sequence ID" value="CCC77598"/>
        <property type="gene ID" value="lp_0022"/>
    </dbReference>
    <dbReference type="GeneID" id="57026883"/>
    <dbReference type="GeneID" id="66448176"/>
    <dbReference type="KEGG" id="lpl:lp_0022"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.20"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_9"/>
    <dbReference type="OMA" id="PRSLMDH"/>
    <dbReference type="PhylomeDB" id="F9US51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-19-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="390" mass="43143" checksum="3AC502E1ED0976EC" modified="2011-10-19" version="1">MRREQVSAIINLLEPSDALQPLTAVRPVGMLPFGGRYRLVDFQLSSVINAGIQNVMVTVPRSGRSVADHLRSGRDWSLNTIRGGLFLSPYNDLKLVAPEKKAALLHHYYDNSIQFLKCSQSEYSVVMSTRNVGNIDLKALLRYHEERNSPVTAVYKRVDPASLIPENTILQLTAKGEATAVVPMSKAKISPKTKQVAKSMAIYLMSTVDLIELLQSANQRGDMISLEELMRQAVIQHNANAFEYTGFQANIHDINSYFAANMAVLDEANFRALFYSSRRIYTKVKNEIPTFFATGSQCRDSLCGTGGYIEGQLDHSVIFRDVLINRDSQVKNAIIMQGARIGAGCKLENVIIDKDAVIGPNLVLKGTSTTPLVISKGQHVFQQAEVAVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9US87</accession>
    <name>F9US87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptp1</name>
        <name evidence="1" type="ordered locus">lp_0069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0069"/>
    <dbReference type="DNASU" id="1061275"/>
    <dbReference type="EnsemblBacteria" id="CCC77634">
        <property type="protein sequence ID" value="CCC77634"/>
        <property type="gene ID" value="lp_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0069"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.56"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_0_0_9"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="PhylomeDB" id="F9US87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-56-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="27895" checksum="15C883AFCD81D174" modified="2011-10-19" version="1">MEGITNLRSLGGYRNKNQQVIKDGLIYRSGQLDQLTPAQTQYLATTLGITRIVDMRSADERHQFPDATWPHVQYHVLDVLAQVMTNDASLQSMISSTGAVHDRMVQLYEQLALDPTARQSYCQFIRLLLVPDQPLLFHCFAGKDRTGVGAALFLKILGISDEQIMADYLLTNQARAAANQQILATMASQLSDEQQRAVNQALLVDADYLSHYFEVIKARYDTFSNYLQTGLGLTSAECQQLRELYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC7</accession>
    <name>F9USC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator, ArsR family,N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2997"/>
    <dbReference type="EnsemblBacteria" id="CCC80057">
        <property type="protein sequence ID" value="CCC80057"/>
        <property type="gene ID" value="lp_2997"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2997"/>
    <dbReference type="HOGENOM" id="CLU_3409579_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="29" mass="3261" checksum="218DD6E130EEE562" modified="2011-10-19" version="1">MEVSGPLLTEAAKIYKVLSNVNRIKILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK0</accession>
    <name>F9USK0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolysing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB2</name>
        <name evidence="9" type="ordered locus">lp_3085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102035.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890644.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3085"/>
    <dbReference type="EnsemblBacteria" id="CCC80130">
        <property type="protein sequence ID" value="CCC80130"/>
        <property type="gene ID" value="lp_3085"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3085"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2577"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_0_9"/>
    <dbReference type="OMA" id="IEHSHQP"/>
    <dbReference type="PhylomeDB" id="F9USK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2623-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="633" mass="73152" checksum="4FD80BB1A80F9CAF" modified="2011-10-19" version="1">MCGLVGCLTDRRKVDNAAYDQVVREMTKMIVHRGPDDEGYFADDNITMGFRRLSIIDLAGGHQPLSYDNERYWLTFNGEIYNYVELREQLIQEGYTFKTDSDSEVILGMYAKYQAKLTTYLRGMFAFVIWDKQEKTLFAARDQFGIKPFYYAIAGDDFYYASESKAIYKILKDKHFDQEALQDYLTFQYVPETETLTKEIKMLAPGCSLTKQLGHAPQIKRYYHWEFHPVVRSEQDYATRLKETLIDSVKIHMRSDVPVGTFLSGGIDSSIVVAIAKQFNPNLKTISVGFERPGYSELDVAQETAAKLNVDNVQMTITPEAFMAAFPHFVWSMDDPLADPAAVPQYFLTKEAVKHVKVCLTGEGADELFGGYTIYHEPESLKAFRYTKPINGALQRIAAMMPAGMRGRSLLMRGTTPLEKRYVGNAFIFNETEKQQFMKHYNRDHSFQQTTRVFYDEAKHYDLISKMQFIDMHTWLNGDLLHNADRTALAHSLELRTPFVDREVFNLAAEIPANLRISHGTTKYILRKAVEDIVPAHVLYRKKLGFPVPIRLWLKDEMYDWAKNIIVTSQTDQYFDKTYFLKLLDDHRAGIRDNSRQLWTVLTFMMWHKLYVEADMLMDSVTANHLAEQVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL0</accession>
    <name>F9USL0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642342.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890654.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3096"/>
    <dbReference type="EnsemblBacteria" id="CCC80140">
        <property type="protein sequence ID" value="CCC80140"/>
        <property type="gene ID" value="lp_3096"/>
    </dbReference>
    <dbReference type="GeneID" id="57026406"/>
    <dbReference type="KEGG" id="lpl:lp_3096"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2586"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_9"/>
    <dbReference type="OMA" id="ERKFDGH"/>
    <dbReference type="PhylomeDB" id="F9USL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2633-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="26265" checksum="369EC032C9175172" modified="2011-10-19" version="1">MKPLVVITGASSGFGAEIAKLFAADNYPLLLLGRRQAKLAALSANFENAMIDTVDVTNYHQFETAVRKAEAKYGKTDLLVNNAGLMLLGNVQNQDPQEWQTMLNTNVMGVLNGTQIVLNDMRDREHGTILNMSSLAGKKTFVNHAAYVASKFGVHGLSETLREENAPKNVRVMLVAPGAAETELLTHVTSKSALSDYEAWKASMGGLTLDPKHVAATVKFMYDMPQNVNIREVDIAATAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN9</accession>
    <name>F9USN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642371.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890683.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80169">
        <property type="protein sequence ID" value="CCC80169"/>
        <property type="gene ID" value="lp_3129"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3129"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2617"/>
    <dbReference type="eggNOG" id="ENOG5032IIS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196714_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2662-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="79" mass="8699" checksum="6E823550A7BB4B6D" modified="2011-10-19" version="1">MVMQGGIMMKTDIILRVVLGLLFTCLGCFQIFAVRRYFRQLKLHGNAETSAFAPLALWSAFVIGLIFIFVGIAAGFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU6</accession>
    <name>F9USU6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation transporting P-type ATPase</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pacL1</name>
        <name evidence="10" type="ordered locus">lp_0124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888191.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0124"/>
    <dbReference type="EnsemblBacteria" id="CCC77677">
        <property type="protein sequence ID" value="CCC77677"/>
        <property type="gene ID" value="lp_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0124"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.101"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_9"/>
    <dbReference type="OMA" id="NNVMGCV"/>
    <dbReference type="PhylomeDB" id="F9USU6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-99-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="912" mass="99718" checksum="442F8556A9948CCE" modified="2011-10-19" version="1">MIKDDNQSLTSNEEQNDTQNPPDADNLWQLDESALAAKYATDPENGLSTAEAAERLQHNGRNELETKRTSRFVQFIKQFNNSIIYILAAAAVLTFFMHHYSDSIVIGLVIIANAIIGYVQERQAGNALERIREMLISKNFVIRDGKKLEIDARELVVGDLVNLEAGDAVPADMRLISADNFNVQESVLTGETNPVEKQEEPMTETTLALADRKNMVYASTAVTSGSAVGIVTATAEDTEIGHIQQSVSDVKQTTTPLMRNLNSLGVGLSIAIVVAAVLLFLLGMVMDTYSLPTLLIAVITMVVGSMPEGLPASTSVVLAMGTRQMTKKNVIVKSLPAVETLGAVDIVNTDKTGTLTKNEMTVTKVVTPEHTFDVTGVGYDDNGGVNFDGHLKLNGNKVDWHQDNAMEWLVKIAGQTTDAELHFENNRWELTGEPTDGALTTLYRKMTGHGPEVEEVDSLPFDSAFRFSARLADLDGQRLLMVKGSPATVLRLTDQANQTAYWDDAMDDLTADGLRVVALAYQEVDDDVTTIDAQAIGGLHLAGLVGIIDPPREEAATAIAELRQAGVQVKMITGDHPDTAMAIANKLNLAANVKVITGPEIDAMDDQQLQAHIDDYNVFARATPNNKLRIVRAQQANNHVVSMTGDGVNDAPALKQADIGVAMGIKGTEVAKESADMVLADDDFADIVAAVREGRHVFDNIRKTIRFLLPTSFAEGLVVIISILMGHELPLYPTQLLWINMVSALTIQFAFIFEPPEAGIMARGPRNVKSGLLSKLDYFEIGYVSFLISGLGIFAYNYLTALGLPNVVGSTMSLNIIIFGKIFYLFNLRNDHPVISKYFFQNKMAFYIIGILILLQLGIIYLPFMQSVFHTTSINFWYGWGIPIICGIVVLIVTEVGKFIRFRWMGKDGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9USW3</accession>
    <name>F9USW3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0146"/>
    <dbReference type="EnsemblBacteria" id="CCC77694">
        <property type="protein sequence ID" value="CCC77694"/>
        <property type="gene ID" value="lp_0146"/>
    </dbReference>
    <dbReference type="GeneID" id="66448276"/>
    <dbReference type="KEGG" id="lpl:lp_0146"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.118"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_9"/>
    <dbReference type="PhylomeDB" id="F9USW3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-116-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="369" mass="41057" checksum="C6A57B65623BC292" modified="2011-10-19" version="1">MTSFNEPLKFKSGVTLRNRLMMSPMTTTQSFYNGSITHDEIDYYTQRATGLGAVITGAANVEDLGKGWHGELSIAHDTMLPGLSALAHGIQSQGAKAIVQIFHAGRMTHRAVLNGEQIVSASAVAALRDDAETPRAMSIDEIHATISAFGEATRRAIQAGFDGIELHGANTYLIQQFFSPHSNRRTDEYGGRTPQERFRFIDELLKAVFAAVDQYADRPFIVGYRFSPEEFEEPGIRLEDTLWLLSQLRESRLDYVHVSLNNYDRVSRDPQYQDKSIMTYVHEALQGKLPLVGVGGVRTRDDVKTVLQTAELVAVGQQLLYDPTWAVKLAKNADNTMVTAPFEEAVEVTPLSRPLYEFAASRYHSVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USW9</accession>
    <name>F9USW9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0155"/>
    <dbReference type="EnsemblBacteria" id="CCC77700">
        <property type="protein sequence ID" value="CCC77700"/>
        <property type="gene ID" value="lp_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0155"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.125"/>
    <dbReference type="eggNOG" id="ENOG50309KV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064731_0_0_9"/>
    <dbReference type="OMA" id="WRYQMAV"/>
    <dbReference type="PhylomeDB" id="F9USW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-122-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="29671" checksum="8CCE0B8B5BFA263B" modified="2011-10-19" version="1">MWRYQMAVKGSEQELRWLNQQAQRGQLLRRIRGNWYQFQKTATRYQVFSEYVSGNVATEIDDQHTPFKLLARLQLTKPAVQVIYTGTAQTELQGARVDRQDAPLQLKIALAQRGHLLNVMNIRLVVGLILAVIVISLNVSDNVASWGMLAWLLFTFYPAWQASRLHKQANALRVITQQYDDAWRPTMHVFLKNMSTELDTEKVAGLGAWVYVGQDHHGMYWYDLKTLASAAEIKQSLQPIVGDSVSVSIVSWLGLAPIGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX9</accession>
    <name>F9USX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone phosphotransferase,dihydroxyacetone binding sub-unit</fullName>
            <ecNumber evidence="2">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dak1A</name>
        <name evidence="2" type="ordered locus">lp_0166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.29" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0166"/>
    <dbReference type="EnsemblBacteria" id="CCC77710">
        <property type="protein sequence ID" value="CCC77710"/>
        <property type="gene ID" value="lp_0166"/>
    </dbReference>
    <dbReference type="GeneID" id="57026997"/>
    <dbReference type="KEGG" id="lpl:lp_0166"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.135"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_2_9"/>
    <dbReference type="OMA" id="DLDWVKW"/>
    <dbReference type="PhylomeDB" id="F9USX9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-132-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012735">
        <property type="entry name" value="DhaK_1b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02362">
        <property type="entry name" value="dhaK1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="329" mass="35787" checksum="C4027D16A66B1945" modified="2011-10-19" version="1">MQIINEPQNALSQATQGIQWAYPNLTWVPNTFGCYDSNFQDDQIPLIAGGGSGHDPAHWGYVGPGMLTAAIMGTVFQPPTSQEIVKVTKQVTRQRRVFFIVKNFPADVSAFTAAQQQLQKEHWQTGLCIVADDISVDHESLKQRRRGVAGTILVHKILGAAAAQGASIAELTHIAAALVPNIHTIGVAASGARIPGQSTASFNLNPGEIYYGIGIHGEPGYRREPFQSSERLAQELISKLRLNFKWHADDHYAVFVNSLGGTTPMELMVFNNDVHELLTLAALTIDFNKVGTFLTANGMHGLSLTLLSLADPDWLTALNRPVKTAAWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ0</accession>
    <name>F9USZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltodextrin ABC transporter, accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100910.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888235.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0178"/>
    <dbReference type="EnsemblBacteria" id="CCC77721">
        <property type="protein sequence ID" value="CCC77721"/>
        <property type="gene ID" value="lp_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0178"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.146"/>
    <dbReference type="eggNOG" id="COG5521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082338_0_0_9"/>
    <dbReference type="OMA" id="TQFRDEE"/>
    <dbReference type="PhylomeDB" id="F9USZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-143-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016546">
        <property type="entry name" value="Maltodextrose_util_MalA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009136">
        <property type="entry name" value="Maltodextrose_util_MalA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="276" mass="31670" checksum="0ED171DBB416381B" modified="2011-10-19" version="1">MQSTKNKTTAFPVRFFGSLFSPRRMFANRDQFNWLQIIVLFIFLTAVMVMPIPFYYNHQTNFNLSPFLPHIDKMMVSDQMQTAMKTANYRDQRFKDVKHQIIIKTKDNVAGFDLTNDDMAGRKNVINLHASTFQVKSVGSEFKAKYLPGHNLKTNAHAFLVNSWYQSNKVMIGLFMLMALGLIIVGVNLILVNGAAFFLFLSRHNKITHIRNFREGVNLTLMMMGIGSLLAMVIGLIHFDVTIELTVQSLSLAFVVLWVYLKTKFKDPEVDQTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT77</accession>
    <name>F9UT77_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3161"/>
    <dbReference type="EnsemblBacteria" id="CCC80195">
        <property type="protein sequence ID" value="CCC80195"/>
        <property type="gene ID" value="lp_3161"/>
    </dbReference>
    <dbReference type="GeneID" id="57026458"/>
    <dbReference type="KEGG" id="lpl:lp_3161"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2643"/>
    <dbReference type="eggNOG" id="ENOG5030IF1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142052_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2685-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="14357" checksum="23D520AE0D5732B8" modified="2011-10-19" version="1">MTVKINEERAVARVVHQQVQGMLEKNLELLDQVIAPNAKLVHITGTVQSKAEWLQQIRLGRMHYFSSHEVLFQVVVKGKQAQVVMRNELDARIYGFRNTWPLQSKVELVKGPHGWQIIASHASMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA7</accession>
    <name>F9UTA7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chomosome partitioning protein, DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">parB1</name>
        <name evidence="4" type="ordered locus">lp_3198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890739.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3198"/>
    <dbReference type="EnsemblBacteria" id="CCC80225">
        <property type="protein sequence ID" value="CCC80225"/>
        <property type="gene ID" value="lp_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3198"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2673"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_9"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="PhylomeDB" id="F9UTA7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2713-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="296" mass="33156" checksum="4FF09193B5F35198" modified="2011-10-19" version="1">MASKDKDNKALGRGIGALFADVNEPASEEAVVDLDLKDIHANPYQPRRTFDQTALKELASSIEKSGVFQPIIVRQPDAELNKYEIIAGERRFRASKLAHQTTIPAIVRDVTEEQMMEVAVLENLQREDLTPLEEAAAYDSLMKKLKLTQAEVSKRLGKSRPYIANYLRLLGLPDGVKQYIQKGQLSMGQARTLLSLKDKTKLAPLAKRVVKDNMTVRQLEQIVARYNGESKEPAKKVAPKKSPYIRASEEQLQEKFGTAVSIQTKANKADQGKIEIPYLSNEDLTRILEILSIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE3</accession>
    <name>F9UTE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890775.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3244"/>
    <dbReference type="EnsemblBacteria" id="CCC80261">
        <property type="protein sequence ID" value="CCC80261"/>
        <property type="gene ID" value="lp_3244"/>
    </dbReference>
    <dbReference type="GeneID" id="57026525"/>
    <dbReference type="KEGG" id="lpl:lp_3244"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2709"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_0_9"/>
    <dbReference type="OMA" id="TPEYNNG"/>
    <dbReference type="PhylomeDB" id="F9UTE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2749-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20176" checksum="4A1E00B02EAD373F" modified="2011-10-19" version="1">MKIIALVGSIRRSSYNRKLATFVQKRYADQLDVTIPNLGALPFYDQDIELEAPAEVQAFKQTVMDADGVIFVTPEYNHSVPGVLENAIDWLSRVERPLIGKPAMILGATMGPLGTVRAQSHLRQVLDSPGVGMQILPGNEFLLSAVQDKMNADGDLTDNKVVEWLDHCVADYLKFAHQLAAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG5</accession>
    <name>F9UTG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptp2</name>
        <name evidence="1" type="ordered locus">lp_3272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890797.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3272"/>
    <dbReference type="DNASU" id="1062561"/>
    <dbReference type="EnsemblBacteria" id="CCC80283">
        <property type="protein sequence ID" value="CCC80283"/>
        <property type="gene ID" value="lp_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3272"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2732"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_0_2_9"/>
    <dbReference type="OMA" id="RHEQDNF"/>
    <dbReference type="PhylomeDB" id="F9UTG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2771-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="29675" checksum="BE51B7CD3E1B5E08" modified="2011-10-19" version="1">MEHNRVLRLEHGINFRELGGYENTAGQTIKWQKLLRCGGMSLLTNRDLTYLDNYGLRYDIDLRQANEAEMSPDRYPKNTKYINTSVYPFTDNRRFDRRLKRLIKRMVVDDSFNAQTYAQMITDSHAVKVWQNLFATLLANDQPDQSVLFHCAAGKDRTGVAGALIMTALDVPRETIMQDYLLTNAVFMAADSMDTATIITKANAGDLASQFNVAMAVEADNMKMVFRVFDDLYGNGIGYLREVLGLSVADINNLRQLYLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ4</accession>
    <name>F9UTJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890826.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3312"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="CCC80312">
        <property type="protein sequence ID" value="CCC80312"/>
        <property type="gene ID" value="lp_3312"/>
    </dbReference>
    <dbReference type="GeneID" id="57026576"/>
    <dbReference type="KEGG" id="lpl:lp_3312"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2763"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_0_9"/>
    <dbReference type="OMA" id="FTTEYNH"/>
    <dbReference type="PhylomeDB" id="F9UTJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2803-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="329" mass="37332" checksum="FC66021317FCC1B7" modified="2011-10-19" version="1">MRMLEKIEQYIDSCIEAGDIYGASFSLITPKGINQYYHGKQGRDEFAVGLDPAMIYDLASVTKVVGTTTRIFQLLSDHTIHLTDSVARFLPGFTHPEITIKNLLLHNSGLPADIDNLDKMQREDLIKAVYDAPLVTAPGTTYVYSDLGFILLGWIIRAVDGSLARSIQDHVCYPLAMTNTGYNLNRPKIRFVPTEFDPRRGQIQGQVHDYKAFLLNGESGHAGLFSTLTDLSVFIEMMLNFGEYQGKRVLDENVFDWLGEYDENGRTLGWERRAGRHQYFHTGFTGPAVAFDLDRQIGLVVLTNRVYPTSDNQVWNQDRKRVFDLFFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP9</accession>
    <name>F9UTP9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888333.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0294"/>
    <dbReference type="DNASU" id="1061149"/>
    <dbReference type="EnsemblBacteria" id="CCC77819">
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        <property type="gene ID" value="lp_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="57027106"/>
    <dbReference type="GeneID" id="66448386"/>
    <dbReference type="KEGG" id="lpl:lp_0294"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.247"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14278">
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="190" mass="21924" checksum="00D698618C5574A9" modified="2011-10-19" version="1">MVGTKNNRRSQMTERLIQDSLINLLQHQSLDEITVTAVCKAADINRGTFYAHYEDVKDCMQKMEQDATEELLAVIDKHLNPDSLQAILTGIFEVVKKRHAVTSFILTTDQDFLMSFIATTKREILAHNQAEITGIGNREKEYMFEYYLNGIVGVVRYWLKTGLHESPEELASFINDWWYRGKPVKNLAEH</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="CCC77881">
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    <dbReference type="PhylomeDB" id="F9UTW1"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="299" mass="32356" checksum="B86C98097AE918BD" modified="2011-10-19" version="1">MSQPRVILITGASSGIGKATALKLQAQGNIVYGAARRIEKMTDLAAAGVHVLKVDVTDEATLIAAVKTIQVEQGRIDVLINNAGYGSYGSLEDVPVAEGEYQFKVNVFGVMRLTQLVLPLMRAQHRGRIIDVSSIGGKIYQPLSAWYMGTKHAIEGMSDSLRMEVAPFGIDVVIVEPGGIKTEWAGIAEKKLLAVSGETAYHEQAVKVGAMLSLFDQFASNPGVIAKLMVHAVNDVKPKTRYHAGMGAGVSLTARQWLSDRQFDRMMNSAVNGAAKLSKVTRRKDRRTGSRHYRHGKIG</sequence>
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    <accession>F9UTY0</accession>
    <name>F9UTY0_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">lp_0385</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="RefSeq" id="YP_004888414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1956910_0_0_9"/>
    <dbReference type="OMA" id="WMDFEFA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <dbReference type="EMBL" id="CCC77900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14804" checksum="9E3227D02410971A" modified="2011-10-19" version="1">MNIEEINSEILKVNNYLKKCLWMDFEFASVDGGDIVAAGRIDTSYDEFAINIDFRKPYYLSSLLYWNLNNSKPFIELVAGKEMWKVIDKYQVEEGNYIFKINAEDFDTAPIIIASKGLKAEIINKDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA5</accession>
    <name>F9UUA5_LACPL</name>
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        <submittedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3427"/>
    <dbReference type="EnsemblBacteria" id="CCC80407">
        <property type="protein sequence ID" value="CCC80407"/>
        <property type="gene ID" value="lp_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3427"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_0_9"/>
    <dbReference type="PhylomeDB" id="F9UUA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2895-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="31613" checksum="A02A775BE2D8C943" modified="2011-10-19" version="1">MQDTQHERLAFMAQSGIDMQVLSYGNSSPQNLSPEQAVPFSQLANDELAKAVAAHPDRYAGLAVLPVGDPQAAVAELNRAVTTLGLRGVLLKGNYQNKFFDEPFFLPIFEAAATLDVPVYFHPSFIPQAVTSHYFESNQWSDVVTGILSSAGYGWHMDVGIQVIRMIASGIFDKLPGLKLISGHWGELVPLFLERLDDELTTYTDLQYPFSTYYRHNVYVTPSGILSAPQLQFMLAEMGADHLMYSIDYPYKQPETSGSFLDIADLTDEQRAQIAFGTATTLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK4</accession>
    <name>F9UUK4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, mannitol-specific EIIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts34A</name>
        <name evidence="2" type="ordered locus">lp_3542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646203.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3542"/>
    <dbReference type="EnsemblBacteria" id="CCC80506">
        <property type="protein sequence ID" value="CCC80506"/>
        <property type="gene ID" value="lp_3542"/>
    </dbReference>
    <dbReference type="GeneID" id="57026742"/>
    <dbReference type="KEGG" id="lpl:lp_3542"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2953"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_2_0_9"/>
    <dbReference type="OMA" id="HIHTIMA"/>
    <dbReference type="PhylomeDB" id="F9UUK4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2994-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="16725" checksum="2C8FDD38912C5A29" modified="2011-10-19" version="1">MLLDLLNKQTVQVSEGTGLDWKQAIELAAEPLINNKTIEDGYIKEMLNVVESEGPYINIGPQIALAHSRPAGNVHEIGLSILKTNHSISLVNDEHPINLWFVLAAVDNNSHLAVIKELMELLTDESAVTAMLNATSEVDILEVIAHEQELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE6</accession>
    <name>Q6LWE6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traF</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222038.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133745.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723581"/>
    <dbReference type="EnsemblBacteria" id="CAG17862">
        <property type="protein sequence ID" value="CAG17862"/>
        <property type="gene ID" value="CAG17862"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17862"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3109"/>
    <dbReference type="eggNOG" id="COG4499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578456_0_0_9"/>
    <dbReference type="OMA" id="YRANELM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3162-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018778">
        <property type="entry name" value="T7SS_EssB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10140">
        <property type="entry name" value="YukC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="472" mass="53310" checksum="002FD434C0CA01CB" modified="2004-07-05" version="1">MSKLNQLLNIEVGTFKRQGNKLILELNHNQFRYDQLSELNELKQADSKFLQLVNVVEQDQKVVLTYTLPDKVRSLKDLPHENKAIRSAIAKEIMAQHVVNDSQYHIALNPANLWYYPMQHVWYAYRANELMPYDDKHSNLAKYKALILFCLTGTPYERLLSNPQEALTKHPDDYLQQVAKATSLNELTEVVNGIEDFVSYHEWQEVETAQQKAKQRLWLSMAGVAIVAVLAVGLVHKSDERKYQSLANQNQAQVTRLKYSGQIQTALNDQKWSEAQKDMKRAGYPSTKQVSAFLKHGQYQQALKVDPSQLNKVVNAAYANKDSGQVANWQLPTKATSKQKDQLKLEKAIVNYDTNTLNNQLSFTTNADVLLRMGQAFLAHNDTQDAQTVQTKLAGVNSPKAQYLKALLSLNSAKNEVSDAQKKLDDANKIDGSKDKDKDKKVDSAKADLKNAQSDQSAAQKQVDQAKHKVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF0</accession>
    <name>Q6LWF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traJ</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222034.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133741.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723577"/>
    <dbReference type="EnsemblBacteria" id="CAG17858">
        <property type="protein sequence ID" value="CAG17858"/>
        <property type="gene ID" value="CAG17858"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17858"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3105"/>
    <dbReference type="eggNOG" id="ENOG50311NX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1720092_0_0_9"/>
    <dbReference type="OMA" id="THGSATW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3158-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17616" checksum="3043BA76F0C68BDE" modified="2004-07-05" version="1">MKDKLLNSVKVSWPYLLTLIIGLYLAEILAGAVMALSRYKLTFADHMPTVLKQLALHPWHYYNLYLGQKNPVLIIVSVAVILYTIYFALKRNSKHKAWETADTETHGSATWGDLKELSDHYFSINAKDLTTAFNKSTKAEVLKSLVDREKSAKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF7</accession>
    <name>Q6LWF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf20</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133734.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723570"/>
    <dbReference type="EnsemblBacteria" id="CAG17851">
        <property type="protein sequence ID" value="CAG17851"/>
        <property type="gene ID" value="CAG17851"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17851"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3073315_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="53" mass="6175" checksum="8FDE241D5E0CE617" modified="2004-07-05" version="1" fragment="single">MPSKADVKAWKAQLVAQAEQQILKLTDSDRFKQYLNTLAKFHHYSARNIESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH5</accession>
    <name>Q6LWH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133716.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17833">
        <property type="protein sequence ID" value="CAG17833"/>
        <property type="gene ID" value="CAG17833"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17833"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3086"/>
    <dbReference type="eggNOG" id="ENOG503304N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343230_0_0_9"/>
    <dbReference type="OMA" id="LLGIWWN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3133-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041151">
        <property type="entry name" value="Bac_RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18008">
        <property type="entry name" value="Bac_RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_RepA_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="102" mass="12134" checksum="A83282E21B2997A1" modified="2004-07-05" version="1">MRRFIGIILNAKYRVEKDHKDIGVIIPLDDEELKPLMTKALRRYFNVLRSNEKHIKNVENYLYGTMQNLFGVWWNKQAAREYAAKHPEEEKSADNDNSGLYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-12" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S49</accession>
    <accession>F9ULE9</accession>
    <name>RHAB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnulokinase</fullName>
            <shortName evidence="1">RhaB</shortName>
            <ecNumber evidence="1">2.7.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:L-rhamnulose phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-rhamnulose 1-kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Rhamnulose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaB</name>
        <name type="ordered locus">lp_3595</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20117"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the rhamnulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891070.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S49"/>
    <dbReference type="SMR" id="Q88S49"/>
    <dbReference type="STRING" id="220668.lp_3595"/>
    <dbReference type="EnsemblBacteria" id="CCC80556">
        <property type="protein sequence ID" value="CCC80556"/>
        <property type="gene ID" value="lp_3595"/>
    </dbReference>
    <dbReference type="GeneID" id="57026789"/>
    <dbReference type="KEGG" id="lpl:lp_3595"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3000"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_9"/>
    <dbReference type="OMA" id="GNLLMQM"/>
    <dbReference type="PhylomeDB" id="Q88S49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3043-MON"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01535">
        <property type="entry name" value="Rhamnulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02627">
        <property type="entry name" value="rhamnulo_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000090536" description="Rhamnulokinase">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01535"/>
        </source>
    </evidence>
    <sequence length="488" mass="55266" checksum="1155DC33710FD9FA" modified="2003-06-01" version="1">MKSYIAVDIGASSGRLMLGQQKRGQLTLKEVHRFSNGFAMKDGHDRWDVDHLIHEIFKGLEKVKKMGIKDVELGIDTWAVDYVLVGENGHKLEDPISYRDKRTHNAIQQLTSDLPKEYIYEKTGIQFQDFNTLYQLYKENHDLLAKTDKIMMMPDYLGYVLTGNAVTEITNASTTQMLNLRVGLFDKDLLGKVNVSQDQFPRLVESGSVLGNVSHKWHTQYDIPEVEVVTVATHDTASAVVGTPGEGDRWAFLSSGTWSLLGTELNVPENGLQAFHENYTNEWGAYGTYRFLKNIMGLWVAQCVRHELGDQYSFGELADLAQQVRPFQQFIDINDERFTNPENMIKELQDYCRETKQTIPETPGELFQAIYSNLSLFYANELNKLDRILGYHIDTLNIVGGGSNVALMNQLTSTLANIKVVAGPSEATAVGNIMVQMITSDEVENIGAGRRLIETSFDLKRYLPETNKYGDILKEYQRFLTNKSKEMV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UT9</accession>
    <accession>F9UQR7</accession>
    <name>ATPF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit b</fullName>
            <shortName evidence="1">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpF</name>
        <name type="ordered locus">lp_2368</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641439.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890070.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UT9"/>
    <dbReference type="SMR" id="Q88UT9"/>
    <dbReference type="STRING" id="220668.lp_2368"/>
    <dbReference type="EnsemblBacteria" id="CCC79556">
        <property type="protein sequence ID" value="CCC79556"/>
        <property type="gene ID" value="lp_2368"/>
    </dbReference>
    <dbReference type="GeneID" id="57025900"/>
    <dbReference type="GeneID" id="66450113"/>
    <dbReference type="KEGG" id="lpl:lp_2368"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2001"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_2_9"/>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="PhylomeDB" id="Q88UT9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2040-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000368547" description="ATP synthase subunit b">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="171" mass="18723" checksum="E3E8D2B282D8EEB1" modified="2003-06-01" version="1">MLSHLIIGASGLYLGDMLFIGISFIVLMALISVVAWKPITKMMADRADKIANDIDSAQKSRQEASDLADQRRDALSHSRAEASEIVADAKKSGEKQRSSIVADAQNEATQYKQNARKDIEQERQDALKNVQSDVADISVAIATKIIKKQLDPEGQQALINSYIEGLGKHES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V24</accession>
    <accession>F9UQI2</accession>
    <name>DAPEL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyldiaminopimelate deacetylase</fullName>
            <ecNumber evidence="1">3.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2263</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate</text>
            <dbReference type="Rhea" id="RHEA:20405"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58767"/>
            <dbReference type="EC" id="3.5.1.47"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.47" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101699.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V24"/>
    <dbReference type="SMR" id="Q88V24"/>
    <dbReference type="STRING" id="220668.lp_2263"/>
    <dbReference type="EnsemblBacteria" id="CCC79471">
        <property type="protein sequence ID" value="CCC79471"/>
        <property type="gene ID" value="lp_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2263"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1914"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_9"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="PhylomeDB" id="Q88V24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1956-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050118">
        <property type="term" value="F:N-acetyldiaminopimelate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01692">
        <property type="entry name" value="DapEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023905">
        <property type="entry name" value="AcetylDAP_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF98">
        <property type="entry name" value="PTHR11014:SF98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000376762" description="N-acetyldiaminopimelate deacetylase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01692"/>
        </source>
    </evidence>
    <sequence length="384" mass="42125" checksum="C7C2EF8388613B2F" modified="2003-06-01" version="1">MVLRETDLIPIYQHLHQIPEIGLQEHETQAYLLSIIGKMPQEWLTIKTIPTLDTAILVKVSGLKHDYRIGYRTDIDALPVTENTGLPFASTHPGVMHACGHDIHMSVALGILSYFAENRPATDMVFMFQPAEENASGGQRLYESGALDGDWMPDEIFAFHDNPNLPTGAIGCRMGTLFAGTCEIHAHLSGKSGHAAYPHQANDMVVAGAALVSQLQTIVARNVDPIQSGVVTLGHFTAGTIGNVIAGEAQIDGTIRALTQEMNMHIQRRVRTITEGIALAYDCNIDLKLNQGGYYPVENNDAITADFIKYMQEDDDVNFIETEPAMTGEDFGYLIHQIPGTMFWLGVDSPYSLHSENMVPHTAAIMSGVNAMTSFLTHRNALHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VD5</accession>
    <accession>F9UQ70</accession>
    <name>RS15_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">lp_2125</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VD5"/>
    <dbReference type="SMR" id="Q88VD5"/>
    <dbReference type="STRING" id="220668.lp_2125"/>
    <dbReference type="EnsemblBacteria" id="CCC79359">
        <property type="protein sequence ID" value="CCC79359"/>
        <property type="gene ID" value="lp_2125"/>
    </dbReference>
    <dbReference type="GeneID" id="49394299"/>
    <dbReference type="GeneID" id="57025665"/>
    <dbReference type="GeneID" id="66449894"/>
    <dbReference type="KEGG" id="lpl:lp_2125"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1800"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_9"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="PhylomeDB" id="Q88VD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1820-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115454" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10536" checksum="17C676246754252E" modified="2003-06-01" version="1">MAISREKKTELINKYARHEGDTGSVEVQVAVLTEDINELNEHLRVHKKDFHSQRGLMKKIGHRRNLLAYLRKEDVNRYRDLIQSLGLRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-28" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ2</accession>
    <accession>F9UQ12</accession>
    <name>LDHD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>D-lactate dehydrogenase</fullName>
            <shortName>D-LDH</shortName>
            <ecNumber>1.1.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ldhD</name>
        <name type="ordered locus">lp_2057</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(R)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:16369"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.28"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889815.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ2"/>
    <dbReference type="SMR" id="Q88VJ2"/>
    <dbReference type="STRING" id="220668.lp_2057"/>
    <dbReference type="EnsemblBacteria" id="CCC79301">
        <property type="protein sequence ID" value="CCC79301"/>
        <property type="gene ID" value="lp_2057"/>
    </dbReference>
    <dbReference type="GeneID" id="57025607"/>
    <dbReference type="GeneID" id="66449834"/>
    <dbReference type="KEGG" id="lpl:lp_2057"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1742"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_1_9"/>
    <dbReference type="OMA" id="VIVTAHQ"/>
    <dbReference type="PhylomeDB" id="Q88VJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1762-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-8683"/>
    <dbReference type="SABIO-RK" id="Q88VJ2"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000075955" description="D-lactate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P26297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P30901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="332" mass="37181" checksum="BA65655CCF083F04" modified="2003-06-01" version="1">MKIIAYAVRDDERPFFDTWMKENPDVEVKLVPELLTEDNVDLAKGFDGADVYQQKDYTAEVLNKLADEGVKNISLRNVGVDNLDVPTVKARGLNISNVPAYSPNAIAELSVTQLMQLLRQTPLFNKKLAKQDFRWAPDIAKELNTMTVGVIGTGRIGRAAIDIFKGFGAKVIGYDVYRNAELEKEGMYVDTLDELYAQADVITLHVPALKDNYHMLNADAFSKMKDGAYILNFARGTLIDSEDLIKALDSGKVAGAALDTYEYETKIFNKDLEGQTIDDKVFMNLFNRDNVLITPHTAFYTETAVHNMVHVSMNSNKQFIETGKADTQVKFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VL2</accession>
    <accession>F9UPZ2</accession>
    <name>AROA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="1">EPSP synthase</shortName>
            <shortName evidence="1">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA</name>
        <name type="synonym">aroE</name>
        <name type="ordered locus">lp_2035</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889795.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VL2"/>
    <dbReference type="SMR" id="Q88VL2"/>
    <dbReference type="STRING" id="220668.lp_2035"/>
    <dbReference type="EnsemblBacteria" id="CCC79281">
        <property type="protein sequence ID" value="CCC79281"/>
        <property type="gene ID" value="lp_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2035"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1720"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_9"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="PhylomeDB" id="Q88VL2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1742-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000088265" description="3-phosphoshikimate 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="1">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <sequence length="432" mass="46021" checksum="BBF80D3F07DEB475" modified="2003-06-06" version="1">MIKKLSIQPASGLQGDLSVPGDKSVSHRGLILGAISQGTTTLHHFLPAADCLSTLTALQKLGVPIKRVDTTVTISGRGLRGLTQPQQPLDMGNAGTATRLLTGLLAGQPFETTLVGDTSLSQRPMERVRQPLQAMGAQVQLTAGHLPMTITGRTLHGSRTEMQVASAQVKSALILAALQADQASTIIEKLPTRDHTERLLQQFGGQIETAPDQRTITVQPQPALVGQSLTIPGDFSSAAFFVTAATIIPNSHVRLTNVGLNPTRTGFLNILRRMGGQVTVDHEHRMGEPVGTLDVRFAQLHPVQVTATEIPAVIDELPLVALLAATANGISTISGAAELRVKETDRIATIVTELQKLGVRITSQPDGFVIDGRKSWRQPTEPLASHGDHRIGMMMAIAALRLAAPAELESAEAVNISYPTFFEDLARLSQGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-26" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VL5</accession>
    <accession>F9UPY9</accession>
    <name>TRUB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">lp_2032</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889792.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VL5"/>
    <dbReference type="SMR" id="Q88VL5"/>
    <dbReference type="STRING" id="220668.lp_2032"/>
    <dbReference type="EnsemblBacteria" id="CCC79278">
        <property type="protein sequence ID" value="CCC79278"/>
        <property type="gene ID" value="lp_2032"/>
    </dbReference>
    <dbReference type="GeneID" id="57025584"/>
    <dbReference type="KEGG" id="lpl:lp_2032"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1717"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_1_9"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="PhylomeDB" id="Q88VL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1739-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000121850" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="307" mass="33636" checksum="AA2FF791D4555499" modified="2003-06-01" version="1">MLNGILPLYKPRGMTSFDCVAKIRRLYQTRKVGHSGTLDPNVDGVLPICIGNATKVVQFLVASGKEYQGSITLGFATTTEDLDGEEIARQAVTEPFTSDQVDAALAQMTGAITQIPPMFSAVKVNGRRLYDYARSGETVERPERHITISSFKQRQASTYDSATQTQTIYFTVACSKGTYVRTLAVDVGKVLGVPAVMSDLTRLKSGGFTLDETVTFEEIAAHVDAGTAGALLAPIDKALSQYPRVTLTDEQWQRVKNGAFITAAEGQQTDPDANTMVALVYQNSLKCLYSYRPDEQRYKPFKMFAVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VR5</accession>
    <accession>F9UPT7</accession>
    <name>RS21_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsU</name>
        <name type="ordered locus">lp_1973</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VR5"/>
    <dbReference type="SMR" id="Q88VR5"/>
    <dbReference type="STRING" id="220668.lp_1973"/>
    <dbReference type="EnsemblBacteria" id="CCC79226">
        <property type="protein sequence ID" value="CCC79226"/>
        <property type="gene ID" value="lp_1973"/>
    </dbReference>
    <dbReference type="GeneID" id="49394186"/>
    <dbReference type="GeneID" id="57025551"/>
    <dbReference type="GeneID" id="66449778"/>
    <dbReference type="KEGG" id="lpl:lp_1973"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1666"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_3_2_9"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="PhylomeDB" id="Q88VR5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1690-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178346" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="62" mass="7560" checksum="AC2AB742BAF18952" modified="2003-06-01" version="1">MAKTVVRKNESLDDALRRFKRTVSKSGTLQEYRKREFYEKPSVKKKLKSEAARKRKNRRRFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VZ4</accession>
    <accession>F9UPL1</accession>
    <name>KCY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
            <shortName evidence="1">CK</shortName>
            <ecNumber evidence="1">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine monophosphate kinase</fullName>
            <shortName evidence="1">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmk</name>
        <name type="ordered locus">lp_1883</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889664.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VZ4"/>
    <dbReference type="SMR" id="Q88VZ4"/>
    <dbReference type="STRING" id="220668.lp_1883"/>
    <dbReference type="EnsemblBacteria" id="CCC79150">
        <property type="protein sequence ID" value="CCC79150"/>
        <property type="gene ID" value="lp_1883"/>
    </dbReference>
    <dbReference type="GeneID" id="57025476"/>
    <dbReference type="GeneID" id="66449708"/>
    <dbReference type="KEGG" id="lpl:lp_1883"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1586"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_9"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="PhylomeDB" id="Q88VZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1612-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000131925" description="Cytidylate kinase">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <sequence length="228" mass="24640" checksum="0F08F02F5757204A" modified="2003-06-01" version="1">MAKQALQVAIDGPASAGKSTVAKLVAKRFGYIYVDTGAMYRAVTYWAMQQHVDLADEAAVITAMKSLKISFKPGEPDQLVFANQEDITAAIRQPDVTNNVSTIAALPQVRTILTEQQREMANAGGIVMDGRDIGTTVLPNAEVKIFLVASAAERAKRRYAENVKKGIDTPLAQLQAEIELRDHKDSTRKVSPLTQATDATLVDTTPMSIDEVVAAIAKIITKKQSSTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WU8</accession>
    <accession>F9UNQ2</accession>
    <name>IF3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infC</name>
        <name type="ordered locus">lp_1515</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889355.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WU8"/>
    <dbReference type="SMR" id="Q88WU8"/>
    <dbReference type="STRING" id="220668.lp_1515"/>
    <dbReference type="EnsemblBacteria" id="CCC78841">
        <property type="protein sequence ID" value="CCC78841"/>
        <property type="gene ID" value="lp_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1515"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1275"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_9"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="PhylomeDB" id="Q88WU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1302-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177531" description="Translation initiation factor IF-3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <sequence length="173" mass="19648" checksum="A32BB630B03A96F7" modified="2003-06-01" version="1">MTIAKDSMVNDGIRAREVRLIASDGEQLGVKSRQEAMQIAEDASLDLVLVAPKAKPPVARIMDYGKYRFEQQKKDREARKKQKVVSIKEVRLSPAIDTNDFNTKLKHAEKFLSKGDKVRVSIRFKGRAITHKDIGRQVLNRMIEATKEFSTVEAYPKMDGRSMFLVLAPKTDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XA9</accession>
    <accession>F9UN89</accession>
    <name>SYL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">lp_1316</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643180.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889192.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XA9"/>
    <dbReference type="SMR" id="Q88XA9"/>
    <dbReference type="STRING" id="220668.lp_1316"/>
    <dbReference type="EnsemblBacteria" id="CCC78678">
        <property type="protein sequence ID" value="CCC78678"/>
        <property type="gene ID" value="lp_1316"/>
    </dbReference>
    <dbReference type="GeneID" id="66449185"/>
    <dbReference type="KEGG" id="lpl:lp_1316"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1110"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_9"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="PhylomeDB" id="Q88XA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1136-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152030" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="580"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="808" mass="92629" checksum="68FE11F39F61821F" modified="2003-06-20" version="1">MAYNHKVIERKWQHYWKENKTFKTLDTTDKKKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRFKRMQGYNVLHPMGWDAFGLPAEQYALKTGHNPKDFTAKNIKNFKRQIRSLGFSYDWDREVNTTDPSYYKWTQWIFEQLYKKGLAYESETLVNWAPDMMGGTVVSNEEVVDGKTERGGYDVYRVPMKQWSLKITAYADRLIDDLDDIDWPENIKEQQRNWIGRSVGASIRFKVAGQPDDTEIEVFSTRPDTLFGASYMVLAPEHDLVEQLTTPEQADAIKAYKAKIASKSDLERTDLNKDKTGVFTGSYGINPVNGEKLPIWIADYVLASYGTGAIMAVPAHDDRDFEFAQKFDLPIKPVIAGDNDYDQQAYTGDGEHINSGFVDGLAKQPAIDKMIDWLGEHHAGEKKVNYRLRDWIFSRQRYWGEPIPVIHWEDGETTLVPEDELPLRLPATKNLEPSGTGESPLANIDDWVNVVDENGRKGKRETNTMPQWAGSSWYFLRYVDPHNREALADYDKLKYWSPVDLYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLVNQGMILGDNHEKMSKSRGNVVNPDDIVDQYGADTLRLYEMFMGPLEASIPWSTDGLHGANKWIERVWRLMIDENNRVRDRITTINDGKLTKIYNETVKKVTEDYEAMRFNIAISQMMVFVNEAYKVDDLPIIYIEGFVKLLSPIAPHLSEELWSLLGHDDTITYATWPTYDESKLVEDTVQIVLQVNGKVRSHAEVAKDMGKDELEKLALADEKIQEFTAGKTVRKVIAIPGKLVNVVAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XJ7</accession>
    <accession>F9UN01</accession>
    <name>CPS2G_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Exopolysaccharide phosphotransferase cps2G</fullName>
            <ecNumber>2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Stealth protein cps2G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cps2G</name>
        <name type="ordered locus">lp_1203</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="PLoS Comput. Biol." volume="1" first="492" last="499">
            <title>Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.</title>
            <authorList>
                <person name="Sperisen P."/>
                <person name="Schmid C.D."/>
                <person name="Bucher P."/>
                <person name="Zilian O."/>
            </authorList>
            <dbReference type="PubMed" id="16299590"/>
            <dbReference type="DOI" id="10.1371/journal.pcbi.0010063"/>
        </citation>
        <scope>IDENTIFICATION AS A STEALTH PROTEIN</scope>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="miscellaneous">
        <text>Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101304.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889104.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XJ7"/>
    <dbReference type="STRING" id="220668.lp_1203"/>
    <dbReference type="PRIDE" id="Q88XJ7"/>
    <dbReference type="EnsemblBacteria" id="CCC78590">
        <property type="protein sequence ID" value="CCC78590"/>
        <property type="gene ID" value="lp_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1203"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1021"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043224_1_0_9"/>
    <dbReference type="OMA" id="IFKYWFR"/>
    <dbReference type="PhylomeDB" id="Q88XJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1033-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235946" description="Exopolysaccharide phosphotransferase cps2G">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="337" mass="39970" checksum="AE8BEA9B376E8C56" modified="2003-06-01" version="1">MRGFLMFTSGPFDIDFVVLWVDGSDEKWLQKRAIYSSTKQQNNAVRFRDYGIFKYWFRAVAKYAPWVHHVYLVTDEQIPNWLSIQNSKVSVIDHKSIMPEDALPTFNSSAIELNIANIPGLSEHFVYFNDDMFLNRQVTPMDFFSEDGLPKDSAVQNAIMPVEDFDHMTANNVMLINQNFNKYQVLRRHPFRFFNFRYGFLNVLSICLLPWPRFTRFQDPHVPISFRKSVFEKVLNLHRDAWNETSHNRFRNRNDNTIWLIRYYQLVTAQFNPRTPFVGKKYNIGEMKKIVNDINTGKHKMICINDQNVSMAEFDNLTKQLRSTFRSKLPQKSEFEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q890C0</accession>
    <accession>F9UST8</accession>
    <name>THIE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-phosphate synthase</fullName>
            <shortName evidence="1">TP synthase</shortName>
            <shortName evidence="1">TPS</shortName>
            <ecNumber evidence="1">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="1">TMP pyrophosphorylase</shortName>
            <shortName evidence="1">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiE</name>
        <name type="ordered locus">lp_0115</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890C0"/>
    <dbReference type="SMR" id="Q890C0"/>
    <dbReference type="STRING" id="220668.lp_0115"/>
    <dbReference type="EnsemblBacteria" id="CCC77669">
        <property type="protein sequence ID" value="CCC77669"/>
        <property type="gene ID" value="lp_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0115"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.93"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_9"/>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="PhylomeDB" id="Q890C0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-91-MON"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000157020" description="Thiamine-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <sequence length="217" mass="22845" checksum="83E413079D570282" modified="2003-06-01" version="1">MTLKFEPTQLRAYFVCGTQDVPGQDLNMVVQTALDAGVTAFQYRDKGNSQLTTVERFALGQQLRERCAQAHVPFIVDDDVELALALQADGIHVGQKDDWVTQVIQRVANQMFVGLSCSTLAEVQIANQLEGIAYLGSGPIFPTTSKADADPVVGLTGLRQLVMTASCPVVAIGGITVAQLPAIAATGAAGAAVISMLTRSPDMAATVKAMLTATEGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q890E7</accession>
    <accession>F9USQ9</accession>
    <name>AZOR1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN-dependent NADH:quinone oxidoreductase 1</fullName>
            <ecNumber evidence="1">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Azo-dye reductase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azo compound oxidoreductase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azoreductase 1</fullName>
            <ecNumber evidence="1">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">azoR1</name>
        <name type="ordered locus">lp_0075</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="1"/>
    <dbReference type="EC" id="1.7.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100869.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888154.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890E7"/>
    <dbReference type="SMR" id="Q890E7"/>
    <dbReference type="STRING" id="220668.lp_0075"/>
    <dbReference type="DNASU" id="1061266"/>
    <dbReference type="EnsemblBacteria" id="CCC77640">
        <property type="protein sequence ID" value="CCC77640"/>
        <property type="gene ID" value="lp_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0075"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.62"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_3_0_9"/>
    <dbReference type="OMA" id="QFKAHHR"/>
    <dbReference type="PhylomeDB" id="Q890E7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-62-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000245927" description="FMN-dependent NADH:quinone oxidoreductase 1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <sequence length="215" mass="25011" checksum="FF4F54108D438851" modified="2003-06-01" version="1">MTKTLIVNAHPDFRNAAHYSVQLEQAFLQLFQTRFPNDTVDVLNLYDTVIPQATVPELLGIWEKQAQHVNLSIEEQRLFAINQQLLQQFKAHHRIVIAMPLHNFNVPARLKDYIDNILVARETFRYTENGSVGLMTDNYRVMLLQASGSIYTRNDRYTPMEFSRLYLDKMFTEIMGFDRFEIVRAQGLQTNGVAVSQALKQAKMDLKAAFERFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV7</accession>
    <name>F9UKV7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643831.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888486.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77972">
        <property type="protein sequence ID" value="CCC77972"/>
        <property type="gene ID" value="lp_0473"/>
    </dbReference>
    <dbReference type="GeneID" id="57024270"/>
    <dbReference type="KEGG" id="lpl:lp_0473"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.389"/>
    <dbReference type="eggNOG" id="ENOG50309QI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831031_0_0_9"/>
    <dbReference type="OMA" id="IEIRHTS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-393-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388014" evidence="2">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="34371" checksum="CFF66E922180CEF6" modified="2011-10-19" version="1">MDHAYRSSWPLIVIVLLGLITLSGCAKNTGGVTASSATTATGNSTTAVLTKADQQISQQKIAAAQKTLAGASESTPAIKKLALGLKYYQEAEEALDNNQLSLAKGYFDTLSSYDGTTDASFIAARQKLVKQYQAVKLANGYYNAARDELSIHDLATAKANIDKLDDVQATHPVIKKLQKKALAMKQAIMNYEASQSTSSGSDSSTVVSSSSAASASDSRTSSSSTSSTSADSSTMTSSSNSSASASSSSSELTTSAIIKQFQDASGVTFTSDTEFNITKETSAYYQITAIYATNESSSSASKTVTDTYRYYPDSGSVTKENSATGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX3</accession>
    <name>F9UKX3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, pyrimidine-binding domain</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tkt1B</name>
        <name evidence="2" type="ordered locus">lp_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UKX3"/>
    <dbReference type="STRING" id="220668.lp_0491"/>
    <dbReference type="EnsemblBacteria" id="CCC77988">
        <property type="protein sequence ID" value="CCC77988"/>
        <property type="gene ID" value="lp_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0491"/>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_9"/>
    <dbReference type="OMA" id="KVDVCYN"/>
    <dbReference type="PhylomeDB" id="F9UKX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-409-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="33850" checksum="BFF6422CC4DB3C62" modified="2011-10-19" version="1">MILPISSRAAFRDELLALAKNDKRLIDIEADLGGQTNQFKAEIPDRYFNMGIAESASLDICTGLAKNGLKPVFSTFAPFVALRAAEHVKLSLAYMHANIIIGSCYGGASGGWFGTTHQSLEDLAIIRALPGIKVACPYGEKETRLTLDHAVASNDPWYIRLGRNNSYSDILNVSEFTPYQWYQPLSTETKVCVVSSGEVATDFCTQVAQEKKVAHLHILESDITSLNKMRLVLEKIKVPIIAVEEHRQFGSLGTVLKTLNLKSEIISYNVNDKWPIYGGSHYEVLDYLDFSISDLKKQVSKFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL14</accession>
    <name>F9UL14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        </source>
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    </dbReference>
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        <location>
            <begin position="357"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="534" mass="57731" checksum="C403B27056304238" modified="2011-10-19" version="1">MPKDHLNTVFKGALILSISSLVAKILSAVYRIPLQNMVGNTGFYVYQQIYPLYGIGMTFALNGFPNFISKLVAEQPDETSKSLIARRAFHILSGLSLVVFFGLQLGATWIAAHMGDVNLAPIISAVAWMFVFMPWLATGRGYYQGKFLMGPTAVSQLIEQVVRVAIIIMAAYFSVRLGWDNYRMGTWAMSSAPLAAICSSLIFTAFGLRYLLAPAPAPTHPLPSYRKLTKRFVIEGGTLCLVAAVVILLQLVDSFTVMRGLVHQGQLPEVAKALKGVYDRGQPLVQLGLVVATAFSATLLPALTDALAKRQPIEFKRQTQAMVHVSLALSMAATVGLVALMPQINRLLFGSLEGTTALRIYIISILFAALITTYTSVLQSLNEYTAMIIGIIAGLATKVLANYIFVVHYGINGASAVTVLSLAVMFAVMWLGSPEDLQQVLLESGYLIKLLALSAVMGIVVILSCHQITALVGPILANTRGMAGIITVIGVLIGVLVFVAGAVYARLFTIREWLVLPYGKRLIKAVAKGKEHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL47</accession>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0577"/>
    <dbReference type="EnsemblBacteria" id="CCC78062">
        <property type="protein sequence ID" value="CCC78062"/>
        <property type="gene ID" value="lp_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0577"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.480"/>
    <dbReference type="eggNOG" id="COG3716">
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    </dbReference>
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    <dbReference type="OMA" id="TLLCMWL"/>
    <dbReference type="PhylomeDB" id="F9UL47"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
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        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="147"/>
        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="33626" checksum="6B92DC1FA3E83FF0" modified="2011-10-19" version="1">MADNKVQITKSDRIKVWMRSNFLQGSWNYERMQNGGWAFTLIPVLKKLYTTKEDRAAALKRHLEFFNTHPYVASPIIGVTMALEEERANGAPIDDVTIQGVKVGMMGPLAGVGDPVFWFTLKPIIGALAASLALGGSIMGPILYFVVWNVLRLGFMWYTQEFGYKAGSKITEDLSGGILQDITKGASILGMFILPALIERWVVVDFSPVKVSRIKQSAGAYIDWDKLPKGAAGIKEALTQQAAGRSLDKYKVTTLQDNLNQLIPGLAALLITFLSMWLLKKKVSPIIIIFGLFAFGVVMHVLGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL77</accession>
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        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase, TrmH family</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="primary">trmH</name>
        <name evidence="2" type="ordered locus">lp_0612</name>
    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888606.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0612"/>
    <dbReference type="EnsemblBacteria" id="CCC78092">
        <property type="protein sequence ID" value="CCC78092"/>
        <property type="gene ID" value="lp_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0612"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.512"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_9"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="PhylomeDB" id="F9UL77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-523-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="27480" checksum="015BB1B2849F9C7A" modified="2011-10-19" version="1">MSNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQYVPKQKLDRLTDNANHQGVAVGVAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGSIMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKVARVTNLVQTVKQLQEAGLWIFGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAASLLIYQGYTSRHPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA9</accession>
    <name>F9ULA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araO</name>
        <name evidence="3" type="ordered locus">lp_3553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891030.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3553"/>
    <dbReference type="EnsemblBacteria" id="CCC80516">
        <property type="protein sequence ID" value="CCC80516"/>
        <property type="gene ID" value="lp_3553"/>
    </dbReference>
    <dbReference type="GeneID" id="57026752"/>
    <dbReference type="KEGG" id="lpl:lp_3553"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2963"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_9"/>
    <dbReference type="OMA" id="DCQIGPN"/>
    <dbReference type="PhylomeDB" id="F9ULA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3004-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="2">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="20112" checksum="6BA24D313B40A63F" modified="2011-10-19" version="1">MIKSEKAKMIAGELFNVYDPELVGERAIARQQVEAFNQLGETNPHKSQQIIKRLFGATGDKIEVHATFRCDYGYNLFVGEDFFANYDCVILDVAPIKIGKHCLLGPKVQIYSVNHPDDPQLRRNGAMGIGKSVNLGDDLWVGGGAIICPGVTLGNNVIVAAGSVVTKSFGDNVVVGGNPARVIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC2</accession>
    <name>F9ULC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional protein: N-acetyl mannosamine kinase, ROK family transcription regulator</fullName>
            <ecNumber evidence="1">2.7.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nanK</name>
        <name evidence="1" type="ordered locus">lp_3567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.60" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891043.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3567"/>
    <dbReference type="EnsemblBacteria" id="CCC80529">
        <property type="protein sequence ID" value="CCC80529"/>
        <property type="gene ID" value="lp_3567"/>
    </dbReference>
    <dbReference type="GeneID" id="57026765"/>
    <dbReference type="KEGG" id="lpl:lp_3567"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2976"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_9"/>
    <dbReference type="OMA" id="PMLEATF"/>
    <dbReference type="PhylomeDB" id="F9ULC2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3017-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009384">
        <property type="term" value="F:N-acylmannosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="30373" checksum="BE0EA47087FDD7E3" modified="2011-10-19" version="1">MTTQYLVFDIGGTTIKYGLIDEALHLSHEGKCLTEHNHDGLILKQLQRVTRDYQAEYSLAGIGVSTAGIVGADGAIQYAGPTISDYQGTPIKAALMAQTGLPVFVVNDVDAALLGEQLAGGAKGATSAYCVALGTGIGGAYVEDGRLMTGAHATANSIGYTLYDPLTKTNYEQRASTLTLEYQLAKYQMSVKDAFEEAKRGTVPYVAIINDWAAEVATGLASILLLFDPDILLIGGAVSLQGQYLVDLLNNALKPLLPPDLIKTKITTAELADKAQLYGAMAGLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ2</accession>
    <name>F9ULJ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein,mannose-related oligosaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641588.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3644"/>
    <dbReference type="EnsemblBacteria" id="CCC80599">
        <property type="protein sequence ID" value="CCC80599"/>
        <property type="gene ID" value="lp_3644"/>
    </dbReference>
    <dbReference type="GeneID" id="57026825"/>
    <dbReference type="KEGG" id="lpl:lp_3644"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3043"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="OMA" id="WLSVFNT"/>
    <dbReference type="PhylomeDB" id="F9ULJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3086-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="36624" checksum="911B15CEDBE7E2B0" modified="2011-10-19" version="1">MAQNAAVPIVKKRNFFQRLWDNRVFLLMVAPGAILLIIFFYIPVLANVVAFQNFQYSDQGFIYSVLHSPWVGFQNFAFFFKSADFWIVLRNTVGYNLTFLLLNFFFAIFFGIVMSQMRNQRLLKAYQTSMLFPYFLSWAILAYFVYAFLSSDKGILNHIIQSFGGTPIDFYNTPWVWPFIIIFLGVWKGIGYNSILYFATAMGIDPSYYDAAMMDGANKWQQIKNVTLPHILPVATLMLILNIGGIFRSDFGLFYLIPRSSGTLINVTQTFDTYIYRALTTTNDIGMSTAAGLMQSVVGALLIIVCNWVVRRKQPESALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ4</accession>
    <name>F9ULQ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888657.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0666"/>
    <dbReference type="EnsemblBacteria" id="CCC78143">
        <property type="protein sequence ID" value="CCC78143"/>
        <property type="gene ID" value="lp_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0666"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.558"/>
    <dbReference type="eggNOG" id="ENOG5030AII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165430_1_0_9"/>
    <dbReference type="OMA" id="NEGMTNY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-577-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021146">
        <property type="entry name" value="Phafe_gp6_head-tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05135">
        <property type="entry name" value="Phage_connect_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13506" checksum="770957AF383ADC0C" modified="2011-10-19" version="1">MSDTQDSSKTLKNVITLLGIAPTDSEKERLTLYIDHAEQAIVLYLGRSVRISELPSGLDYIVENLAVTKFNKFHNEGEKSHSEEGLSFQFNVNDLAPYYPDLQAWIDGQSNTTRGATAIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY0</accession>
    <name>F9ULY0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888733.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0753"/>
    <dbReference type="EnsemblBacteria" id="CCC78219">
        <property type="protein sequence ID" value="CCC78219"/>
        <property type="gene ID" value="lp_0753"/>
    </dbReference>
    <dbReference type="GeneID" id="57024453"/>
    <dbReference type="KEGG" id="lpl:lp_0753"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.634"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_1_1_9"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="PhylomeDB" id="F9ULY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-654-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13134" checksum="1FF3637369FA4833" modified="2011-10-19" version="1">MGFWKRILINTILFIAIAGFFQSSFHVASVWMALIASFVLAILNAAIKPFLLLLSLPITLLTLGLFSIVINGFMLQMTSYVVGKANFGFSSFGMAMVVSILMSIANVIVSNFFAKDGVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM28</accession>
    <name>F9UM28_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101163.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888781.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0809"/>
    <dbReference type="EnsemblBacteria" id="CCC78267">
        <property type="protein sequence ID" value="CCC78267"/>
        <property type="gene ID" value="lp_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0809"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.684"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_9"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="PhylomeDB" id="F9UM28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-703-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16949" checksum="15459A8CE12F9BFA" modified="2011-10-19" version="1">MESIMVTSPEATMAIGAKLGQLVQPGDLILLDGDLGAGKTTFTKGLAKSLGIPNNVKSPTFTLIREYRQGRLPLYHMDVYRLEDGGAEDLGLDEYFDGDGVSVVEWSQFIADLLPTTYLRIAISRDTDADDQRVITFKPIGEHYQRLVDQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM34</accession>
    <name>F9UM34_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nhaP1</name>
        <name evidence="9" type="ordered locus">lp_0815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888787.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0815"/>
    <dbReference type="EnsemblBacteria" id="CCC78273">
        <property type="protein sequence ID" value="CCC78273"/>
        <property type="gene ID" value="lp_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0815"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.690"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_6_2_9"/>
    <dbReference type="OMA" id="AFHTERE"/>
    <dbReference type="PhylomeDB" id="F9UM34"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-709-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="8">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="709" mass="78201" checksum="B0A4E810432A15D6" modified="2011-10-19" version="1">MPIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFIAPMLYNDGREFPKQELWELRGAIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAILSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIGFKYALAAAVTGTFVLGEAVGDFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHASGVVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQATIKGAHTNTFHAVFDVLIVWGILLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGVRGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSLVAAAAILPLMAAKSLPFVTRGSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDLILDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVYLRRVDRREQRFLQATHRQGLPTLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREASKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIENAKNDHTLSRDDYEQQLHGLRIKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM37</accession>
    <name>F9UM37_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">lp_0818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0818"/>
    <dbReference type="EnsemblBacteria" id="CCC78276">
        <property type="protein sequence ID" value="CCC78276"/>
        <property type="gene ID" value="lp_0818"/>
    </dbReference>
    <dbReference type="GeneID" id="57024517"/>
    <dbReference type="KEGG" id="lpl:lp_0818"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.693"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_9"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="PhylomeDB" id="F9UM37"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-712-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="84"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="31515" checksum="DABF2CD5D9C64459" modified="2011-10-19" version="1">MTFNWSGLLTLQNFVRLLDILAVWFVIYELIVLLRGTKAVQLFRGIVVIAIIKAVSVLIGLDTVSWIMDQIINWAVIAMVIIFQPEIRRGLEHLGRGSMFARGKRQNEDEERMIAELDKAIQYMAKRRIGALMSIKMDTGLEDYIETGIALDADITGELLINIFIPNTPLHDGAVIIQDNQIKVAAAYLPLSESNLIPKELGTRHRAAVGISEVTDALTIVISEETGEVSITKDNELMRGMTRENYLRYFRQVLLTPEDSTKQNALQNWFGRVFGGGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM85</accession>
    <name>F9UM85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnH1</name>
        <name evidence="5" type="ordered locus">lp_0881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101188.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888838.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0881"/>
    <dbReference type="EnsemblBacteria" id="CCC78324">
        <property type="protein sequence ID" value="CCC78324"/>
        <property type="gene ID" value="lp_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="57024565"/>
    <dbReference type="KEGG" id="lpl:lp_0881"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.745"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_9"/>
    <dbReference type="OMA" id="ITYFMDG"/>
    <dbReference type="PhylomeDB" id="F9UM85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-760-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388029" evidence="2">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="44"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="53"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="29869" checksum="9A7EB9603CFB3415" modified="2011-10-19" version="1">MKKLKRLIGALGMLAMLVVVLTACGSRQSLAKQDVLTNDKASKTITWGVKADTKLFGLMDVKDNQIKGFDADIATALTKRVLGKNATAKFVQVTSQTRIPLLKNGNIDAILATMTITPEREKQVDFTNSYFDAGQSLLVKKGSAIKSVKDLNKSGTKVLGVTGANSVENIKKAAPKAKVLELSDYAQAMTALKSGQGVALTTDNGILYGMASQNPGYEVVGGTFTKEPYGIAVNKGQEPLKKALNKALKEIEADGTYNRILKKWFGNVAGFDYKEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA1</accession>
    <name>F9UMA1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation transporter, small multidrug resistance (SMR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">smr</name>
        <name evidence="6" type="ordered locus">lp_0898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0898"/>
    <dbReference type="EnsemblBacteria" id="CCC78340">
        <property type="protein sequence ID" value="CCC78340"/>
        <property type="gene ID" value="lp_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="57024581"/>
    <dbReference type="GeneID" id="66448844"/>
    <dbReference type="KEGG" id="lpl:lp_0898"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.761"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_1_1_9"/>
    <dbReference type="OMA" id="WPTIAFC"/>
    <dbReference type="PhylomeDB" id="F9UMA1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-776-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11181" checksum="6FF0160B79C636A5" modified="2011-10-19" version="1">MTWIYLIIAGLFEVVWATMMKLSNGFSHFGYAAATVVGMVLSFGFLALATKHLPLSIAYPIWTGIGAVGAIIVGLVFFKDTIAPITWIFIAMLVIGIIGIKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD3</accession>
    <name>F9UMD3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0935"/>
    <dbReference type="DNASU" id="1064027"/>
    <dbReference type="EnsemblBacteria" id="CCC78372">
        <property type="protein sequence ID" value="CCC78372"/>
        <property type="gene ID" value="lp_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0935"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.793"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426357_0_0_9"/>
    <dbReference type="OMA" id="FERRYSC"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-808-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="21657" checksum="CCAA3C95A0834809" modified="2011-10-19" version="1">MTVTFSNEDDHKFHKLTDQCFTANPKLLTKANISVPLTTRTIQPRRYFVATRINQAALATATWQPVTGAIALHKHERLIYDLGALYVGHFQVAIDVAGSPMDAPLLMRTRFAEQLQELSVDASRVTSWLPTAWIQDDTHHVELLPTTVQFERRYSCRYIMLEPVGQSLKWQPVLADAEFEETIDDFRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME6</accession>
    <name>F9UME6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888899.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0950"/>
    <dbReference type="EnsemblBacteria" id="CCC78385">
        <property type="protein sequence ID" value="CCC78385"/>
        <property type="gene ID" value="lp_0950"/>
    </dbReference>
    <dbReference type="GeneID" id="57024626"/>
    <dbReference type="KEGG" id="lpl:lp_0950"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.807"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473426_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-821-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015046">
        <property type="entry name" value="LciA_Immunity-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08951">
        <property type="entry name" value="EntA_Immun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="21400" checksum="A0A1558EDBB04C7A" modified="2011-10-19" version="1">MKIVIGTKIKEQRQQHEWSQQTVAERLHVSRQTISKWELGKSYPDLELLVALSKLFSVSTDELLGLSRRPVQRPWWQLLLRKRSRTDMTVKWYSGGQDRARVAVGIISDLVANLNTTNEQPLRQLLATYYQELLEQRTGSVLGVFDRMNLDISKCLRQQQIKLSPENEQLMQQLVGLNMIYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMF8</accession>
    <name>F9UMF8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluE</name>
        <name evidence="5" type="ordered locus">lp_0963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101230.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888911.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0963"/>
    <dbReference type="EnsemblBacteria" id="CCC78397">
        <property type="protein sequence ID" value="CCC78397"/>
        <property type="gene ID" value="lp_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0963"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.820"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_8_2_9"/>
    <dbReference type="OMA" id="FGTSGIM"/>
    <dbReference type="PhylomeDB" id="F9UMF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-833-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="85"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="32282" checksum="E523A2029A19E517" modified="2011-10-19" version="1">MEFTWQHQGQPMAMKRFLTTHAISMRTIKAIKHGTGAFLVNNQVQTGVITIHDGDIAGIQLPDEAPDTAVAVSEQPIQIEYEDANWLVLNKTAGLTSVPGPSNRTDTLVNRIKGYLMASHASNQRPHLITRLDRDTSGLVLVAKHRVAQGMLTEPRIAAQLVKTYQAWIEGTITPASGTIDRPIGRVADSPRRVVTTAGQRAITTYQVEADQLQHNVSRLRLELVTGRTHQIRVHLTTLGHPLLGDALYGGNLGWIQRQALHAASLQFFDPFSEQTLHFEAALPADLQALNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR7</accession>
    <name>F9UMR7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Citrate [pro-3S]-lyase] ligase</fullName>
            <ecNumber evidence="1">6.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">citC</name>
        <name evidence="3" type="ordered locus">lp_1106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10158"/>
            <dbReference type="Rhea" id="RHEA-COMP:13710"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82683"/>
            <dbReference type="ChEBI" id="CHEBI:137976"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.22" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1106"/>
    <dbReference type="EnsemblBacteria" id="CCC78506">
        <property type="protein sequence ID" value="CCC78506"/>
        <property type="gene ID" value="lp_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1106"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.935"/>
    <dbReference type="eggNOG" id="COG3053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063190_0_0_9"/>
    <dbReference type="OMA" id="YVFVLSE"/>
    <dbReference type="PhylomeDB" id="F9UMR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-949-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008771">
        <property type="term" value="F:[citrate (pro-3S)-lyase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02169">
        <property type="entry name" value="Citrate_lyase_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005216">
        <property type="entry name" value="Citrate_lyase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013166">
        <property type="entry name" value="Citrate_lyase_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40599">
        <property type="entry name" value="PTHR40599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08218">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005751">
        <property type="entry name" value="Acet_citr_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00764">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00124">
        <property type="entry name" value="cit_ly_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Citrate_ly_lig" evidence="2">
        <location>
            <begin position="151"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="351" mass="38533" checksum="541C76F3BBB82E99" modified="2011-10-19" version="1">MAAQVVEMQLNNPHEHAQWQQFLTSLGITNFSPQEVEHIDVTLGLIEDGQLVGTGSLAGNVLKYVGVCNKNSQPGARFNQIVSALVNRLFQAQIFHMMVFTKAKYSASFQHVGFKELAHSDEAAVLENGAPDMTDFVKQLPMIPNQAQQRVSAIVMNANPFTRGHRYLVEQAAAVSDLVYVFVVATDASLFRTAERVKLVQQGTADLANVRIVSGQDYLVSAATFPAYFLDSAASAIEAQTTLDARIFKQQLAPALHITTRFVGSEPTSRTTAIYNRVLQRELPPAVAVRVISRTTVANQPISARTVRQRIRSGNLTELNQLVPATTAQFIKNNLTTLQARIQKGMKIDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX4</accession>
    <name>F9UMX4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glf1</name>
        <name evidence="5" type="ordered locus">lp_1176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101279.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1176"/>
    <dbReference type="EnsemblBacteria" id="CCC78563">
        <property type="protein sequence ID" value="CCC78563"/>
        <property type="gene ID" value="lp_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1176"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.994"/>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_9"/>
    <dbReference type="OMA" id="INVHKYG"/>
    <dbReference type="PhylomeDB" id="F9UMX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1006-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="149"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="43273" checksum="B8FE82C668E1F6F7" modified="2011-10-19" version="1">MSKYDYLVVGAGLFGAVFAHEAALRGKHVKVIEKRNHIAGNIYTKEVDGIQVHQYGAHIFHTSDKQIWEYVNQFAEFNRYTNSPVANYKGHMYNLPFNMNTFSELWGVRTPAEAQAKIQEQKDAAQLSGEPKNLEEQAISLIGTDIYEKLIKGYTEKQWGQKATDLPAFIIRRLPVRYTYDNNYFNDTYQGIPIGGYTQIVEKMLDHPEIDVETGVDFFANKNQYLADFPKIIFTGMIDQYFNYQLGELEYRSLRFETEERDVDNYQGNAVINYTDAETPYTRIIEHKHFEFGKGDKGKTIITREYPANWKRGDEPYYPVNNTRNNTLYKQYAELAKQEGNVIFGGRLGQYRYYDMHQVIHAALVTVNKISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY1</accession>
    <name>F9UMY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps1G</name>
        <name evidence="3" type="ordered locus">lp_1183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1183"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="1063150"/>
    <dbReference type="EnsemblBacteria" id="CCC78570">
        <property type="protein sequence ID" value="CCC78570"/>
        <property type="gene ID" value="lp_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1183"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1001"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_33_1_9"/>
    <dbReference type="OMA" id="EYYQAMD"/>
    <dbReference type="PhylomeDB" id="F9UMY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1013-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="376" mass="43199" checksum="560A4B92A616A509" modified="2011-10-19" version="1">MIMRILVVGDFLKTSGMTRYIFNVIGRIHASDFQVDALSISGKDECKGQVKKMGWGFYCVQAANNNLLRHLVQSFIFFKKHAKDYDVIHFNESALWNFLPIIFAHLFGAKRIILNSHNTYFATEGSKKLYVVLEIMHRIGKWLVAHVVAQNIAVSEEAARWMFTRKTINRHEYKIIVNGIELEKFAYNKEQRFKIRKSLKINEDTFLFGNVGIFNARKNQLRLLEIFNELVKRNLDVKLVLVGDGPIKEAIVAKISELRLADKVVMTGLINNTNEYYQAMDGVIMPSLNEGLSTVLLEAQTSGLQFILSEGLPLGNHIDLLVHEVPLSESNRVWADVVEHNMNREKREVFGSIMQKKGFDVELSAKELYQTYLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN73</accession>
    <name>F9UN73_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101339.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1293"/>
    <dbReference type="DNASU" id="1062778"/>
    <dbReference type="EnsemblBacteria" id="CCC78662">
        <property type="protein sequence ID" value="CCC78662"/>
        <property type="gene ID" value="lp_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1293"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1094"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_2_9"/>
    <dbReference type="OMA" id="QFLMERM"/>
    <dbReference type="PhylomeDB" id="F9UN73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1120-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="31213" checksum="C120A705F8292272" modified="2011-10-19" version="1">MVKIAVLSDVHGNATALEAVLADAQKQHVDEYWTVGDMTVRGPESERCLTLLDRVHPTAYVLGNHEENYQKVMAANPNTFTKPKQIMATVLTAFDRRQLSSTHFERLLNLPMTVIKHVGPLTIRLQHVLPTVASGHALAPTASQANFDQAAEGDVDIVIYAHTHQPIMRYATTGQLILNAGTVGLPTAINPHLRQPRANYLLLTIDETGLQHVDYRAVDFDWQRAITIAQNTHLPYFEFYEQTLQTNTYQYAPSAVAAYNTQHDMAREARKILLENRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC6</accession>
    <name>F9UNC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889229.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1362"/>
    <dbReference type="EnsemblBacteria" id="CCC78715">
        <property type="protein sequence ID" value="CCC78715"/>
        <property type="gene ID" value="lp_1362"/>
    </dbReference>
    <dbReference type="GeneID" id="57024964"/>
    <dbReference type="KEGG" id="lpl:lp_1362"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1146"/>
    <dbReference type="eggNOG" id="ENOG5030HDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568772_0_0_9"/>
    <dbReference type="OMA" id="ACLIPVD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1173-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19377" checksum="59DDDC106A31854D" modified="2011-10-19" version="1">MKTATQLLQQYTFEPVKDKMRVEQHALAVQHQDRAIPFGHFKIRLKNIDNQQTYLLELKQALQLTTTSGFQLRSRLHGVHVKHAQHMMPTGYHVLASLTIKAAPRDAHEFVHDKTKIACLIPVGDHAAKTLPAQVPLYAFTDNHQLAINQQAMAQLFLTCIKSQQRQQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE4</accession>
    <name>F9UNE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889247.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78733">
        <property type="protein sequence ID" value="CCC78733"/>
        <property type="gene ID" value="lp_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1390"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1164"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_3_1_9"/>
    <dbReference type="OMA" id="VVEQDCV"/>
    <dbReference type="PhylomeDB" id="F9UNE4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1195-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="148" mass="17023" checksum="7CCC8ECCE5826C94" modified="2011-10-19" version="1">MQFITTSFDELTVRQLQQIYKLRVAVFVVEQACPYQEVDDTDLMAWHLRGLDSTGQLLVYARLMREANQQARIGRVITNPAVRGHGYGQQLLQQAIVQIQALWPSTTQINIQAQHYLDRFYRGFGFQPVSGVYLEDGIPHQNMILTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG9</accession>
    <name>F9UNG9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101397.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1419"/>
    <dbReference type="EnsemblBacteria" id="CCC78758">
        <property type="protein sequence ID" value="CCC78758"/>
        <property type="gene ID" value="lp_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1419"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1190"/>
    <dbReference type="eggNOG" id="ENOG5030B1J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666969_0_0_9"/>
    <dbReference type="OMA" id="NDHAEHE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1219-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="412" mass="46782" checksum="B94C7476FE38A5D4" modified="2011-10-19" version="1">MARDGTVTETNDLKLHALGEIIGMNEQEAYVTTFYWLADCWLETSYLGLEDEFDDDEIDDAVKSLLNRMQAGAIYEVTADDPMWQAWKRAVRAVLTPNDHAEHEVDETDGEDELVLPAGVRPERQLEEVQAYAAMNAFLQAQDQEYLQEIGKRAATQVSGAGWQVWRAHRQSMHPESAAPLTLTAEQLPAVMWAFFDKYQDTEDSFEIFELVNRLEQWQKSADRDLDAQWSQLVAKSQIDPAAITLMQGLSLAIEFFDQLEWDGDLTAKATLQNKLMQRTLDDTLNDETTANWTDAWQHWDLADPLTTEQWARRFDPADDYEDDEDESEEDGAARPAWQLGASYSTVLIAMRLVAYGVLRPESVPGMATVKMANRALAATVSIGIVLVAWLVTAILITIVIWGWRWLRKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL8</accession>
    <name>F9UNL8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaD</name>
        <name evidence="1" type="ordered locus">lp_1479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Ursing B."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="449" mass="50074" checksum="59A911D45E3E474B" modified="2011-10-19" version="1">MTRLRNSGLDFSVATLNFLANVGIVLPYVLILFKYQQTHNANYLAAIVVFYVARAASVFGTKHLNLKASSYLLICLWLGALGSLLFSLTANIVAVLAGALFLGYTSANIWPYYLTIKLHLSAQTDFKLKKIYWLIFLVLGILFVLDFALNWGYRLAFILLALLFIIALPAGRLLSQFSLAFYDQHEMAQVRPIKPWRVVVFIVFFAAIGLLTLLRKASLQIALPAVLGIIVVAIVLLNLELAADWQSMPANKLRIVDRGFLLSFVLLFNSFFGVFVFGKMGMYLVFAIYLLGFETGRPLYLLLGRHDLHRATTIARGGLIVGHLLVATAQPVLYVAGLLLISLYVGFENPAINTSVYATEVNDPDLAIIHKYRFSTYGGLLCQLCFFGLLVIVSSFRQLNLLNFFNPASTALKNTYLVGMVWPLTAISLIVTLVTLYGQYYFKRAQSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC79147.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_1880"/>
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1880"/>
    <dbReference type="eggNOG" id="ENOG5030BSN">
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    <dbReference type="HOGENOM" id="CLU_3365618_0_0_9"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="35" mass="4121" checksum="ECD9609F8648D807" modified="2011-10-19" version="1">MLLQHSYAIFDEEMMLVIVSLIFGPLKNDHLDQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="3" type="ordered locus">lp_1882</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="66449707"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
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        <property type="entry name" value="S1_dom"/>
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        <property type="entry name" value="S1_domain"/>
    </dbReference>
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        <property type="entry name" value="PTHR10724:SF7"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
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            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="429" mass="47160" checksum="1BC9E8CBCE54F059" modified="2011-10-19" version="1">MSENENSQEKNELLDALNSVEEVNVGDVVKGEVLAIDDDKQVIVGIQGTGVEGVVPLKELSTQRVDDVNEAAKVGDVLDLVVISRIGSDKENGSYLLSHRRLEARKVWDDVEKEYEAGHTIKAPVTQVVKGGLVVDAGVRGFIPASMIDDHYVEDLNAYKGQELELKIIEIEPSENRLILSHRAVVEKQREAQREEALKTLQAGDVVEGKVARLTNFGAFVDLGGIDGLVHVSEISYERVEKPADVLKVGQEVTVKILSVDADRERVSLSIKATLPEPWDGIEEKAPQGAVLDGKVKRLTSFGAFVEVFPGVEGLVHISQISHQHIATPNDVLKVGQEIKVKVLDVRPDEKRLALSIKALEEKPQTADDDNESQPERRSNNNRRRNNNRDNRTASERSTANAPEESTGFTLGDLIGDELKNAESNNDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL3</accession>
    <name>F9UPL3_LACPL</name>
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        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="primary">recQ2</name>
        <name evidence="7" type="ordered locus">lp_1885</name>
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    <organism evidence="7 8">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101581.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889666.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1885"/>
    <dbReference type="EnsemblBacteria" id="CCC79152">
        <property type="protein sequence ID" value="CCC79152"/>
        <property type="gene ID" value="lp_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1885"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1588"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_9"/>
    <dbReference type="OMA" id="CRWQFLL"/>
    <dbReference type="PhylomeDB" id="F9UPL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1614-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="221"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="479" mass="53508" checksum="27B5AA09F7A89496" modified="2011-10-19" version="1">MSEDELYELLKTKYGFDEFRPGQLAVIQKLLAGQDVLAVLPTGTGKSLIYQLVGTALPGLVVVVSPLISLMQDQVARLNYQGEKQVAALTSQLDYGARQYLLNHLGQLKFLFISPEMLGQDIIQTALMQVQLALLVIDEAHCISTWGPDFRPDYRRLGQIRQRLQAPTTLMLTATATQRVRQDILTQLTVPDAQQILYSVNRPNIYLAVEQVNDEASKRATLQHLVTSARGPVIVYFTSKRQTDLIAEWLRTTTTLRVAAYHAGLATDDRFKIQQQFMAGQLDVICATSAFGMGINKADIRLVIHYHLPTTLADYVQEIGRAGRDGQQAMAIMLYAPGDENLVRNLNELTAATPNEIQQDYSRYQAQQPPTDDRSKVLQSYWLQGTPPTTVATIFADRQVAKERELRTLMSYVQTTTCHRTVMLTYFGEPAVTHTDQCCQLAAEPLPLAALGLMATHDEPTATIMSWDQHLAQLFLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR7</accession>
    <name>F9UPR7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1947"/>
    <dbReference type="DNASU" id="1061672"/>
    <dbReference type="EnsemblBacteria" id="CCC79206">
        <property type="protein sequence ID" value="CCC79206"/>
        <property type="gene ID" value="lp_1947"/>
    </dbReference>
    <dbReference type="GeneID" id="66449765"/>
    <dbReference type="KEGG" id="lpl:lp_1947"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1644"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_0_9"/>
    <dbReference type="OMA" id="KIEMLFI"/>
    <dbReference type="PhylomeDB" id="F9UPR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1669-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="17075" checksum="5D1C09CD4E94753B" modified="2011-10-19" version="1">MLIKSFPPAERTPQLISQLTQLWRQSVDASHHFLTPAEITTIEHEVPTALRTVPQLLVAVDDQNTPTGFIGIDGSLVAMLFIAPAASGAGIGTALLQTSIQDYGATTLTVNEQNPRARQFYEHRGFQVTNRQPTDDQGRPYPLLTMTYNCDPLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPY8</accession>
    <name>F9UPY8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribC2</name>
        <name evidence="13" type="ordered locus">lp_2031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101639.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2031"/>
    <dbReference type="DNASU" id="1061729"/>
    <dbReference type="EnsemblBacteria" id="CCC79277">
        <property type="protein sequence ID" value="CCC79277"/>
        <property type="gene ID" value="lp_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2031"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1716"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_2_9"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="PhylomeDB" id="F9UPY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1738-MON"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavokinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="186"/>
            <end position="311"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="36966" checksum="35B112F0E7C1AD06" modified="2011-10-19" version="1">MQVINLKYPVALSQIPEGPIVLALGFFDGVHRGHQQVVATARQAAQAQHAKLAVMTFDQHPSVVFKHTDPQQVRYLTTIDQKTALMSELGVDILYVLHFDATVGAMPPQTFVDQLIVGLHAQTVVAGFDYTYGPAEIANMQRLNDYGHNRFEIIEVPKAELDAEKISSTRIRRALDAGDIDTANRLLGYQYETAGEVVHGEARGRTLGFPTANVAHGPNTRVPGIGIYATMVQIGTRWVMGMASVGRNVTFGDHRPITVEIYLLDFRGDLYGHNLTVRWGHRMRGEIKFAGADALVAQLKRDEQNTRDYYVAHPFVVAPRIQVAQQSNRLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ46</accession>
    <name>F9UQ46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide repeat unit transporter (Flippase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cps4J</name>
        <name evidence="8" type="ordered locus">lp_2099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644570.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889849.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2099"/>
    <dbReference type="EnsemblBacteria" id="CCC79335">
        <property type="protein sequence ID" value="CCC79335"/>
        <property type="gene ID" value="lp_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2099"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1776"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_1_9"/>
    <dbReference type="OMA" id="LFCTLVE"/>
    <dbReference type="PhylomeDB" id="F9UQ46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1796-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="235"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="383"/>
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            <end position="408"/>
        </location>
    </feature>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="483" mass="55118" checksum="A5A283B0F6EB07BF" modified="2011-10-19" version="1">MLVSIRNKYRHLPKQVKASLWFLVCAFFEKSISIIATPIFTRIMSTSEYGQFNVLYSWLTIVTIIVSLNLCYGVYTQGLIKFSHDRRRYSAALQGLTVVLVLAWTLVYLGFRDFWNSVFSLTTTQMLAMLLMVWTSSVFNFWAGERRVALQYKSLVMVTLLVAIAKPLVGVLLVVYANDKVTARFLGLALVELVGYTGLFFVQMYRGKTFFSRHFWRHALMFNIPLAPHYLSQIVLSSADRIMIANMVNTKSAGIYSLAYSLSQIMILFNVALSQTLSPWIYQKIKDRRVADIAGVAYGALVLIAVVNLLLIAFAPEIVSIFAPRAYAKATWIVPPIAMSVFFIFAFDLFAKFEFYYERTSLIMIASVIGAVLNVALNYWLIPILGYEVAGYTTLICYVMYAAVHYWFMNRICREKLDTLPYDRKILGMITLTFLAVGFLFLGGYHSVVLRYLLILITAVVGFSKRDYLMTIVNQMLRVRKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ54</accession>
    <name>F9UQ54_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cps4B</name>
        <name evidence="4" type="ordered locus">lp_2107</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889857.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2107"/>
    <dbReference type="DNASU" id="1064041"/>
    <dbReference type="EnsemblBacteria" id="CCC79343">
        <property type="protein sequence ID" value="CCC79343"/>
        <property type="gene ID" value="lp_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2107"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1784"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052027_2_4_9"/>
    <dbReference type="OMA" id="MSIVMEY"/>
    <dbReference type="PhylomeDB" id="F9UQ54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1804-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388092" evidence="3">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="25623" checksum="D34EC4CA4CCD2728" modified="2011-10-19" version="1">MKLRRRVANMHTGIQLTTLTAPMSVVTEQVKTIRTNLNYAMVGKPLKTLMITSAIQGEGKSTVSSNLAVEYAKKGLQVLLVDADLRRPTIHQTFAISNQRGVSSWLSGQLTDVNEAIYPVLDHLFVMPSGPKPPNPAELLASDRMSEFLTVATRKLDLVIVDAPPILPVTDARILAGQVDGTVLVVRQNFVEKVAVRQAVSALKNARAQLLGTILNDVDIKTHGYGYGYYGTETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD8</accession>
    <name>F9UQD8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnT</name>
        <name evidence="9" type="ordered locus">lp_2213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79427">
        <property type="protein sequence ID" value="CCC79427"/>
        <property type="gene ID" value="lp_2213"/>
    </dbReference>
    <dbReference type="GeneID" id="57025737"/>
    <dbReference type="KEGG" id="lpl:lp_2213"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1869"/>
    <dbReference type="eggNOG" id="COG1114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036807_0_1_9"/>
    <dbReference type="OMA" id="HVFFKGF"/>
    <dbReference type="PhylomeDB" id="F9UQD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1888-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="449" mass="47872" checksum="C2DBA9AD83CA9A19" modified="2011-10-19" version="1">MNNRLSGRNLLFIGTMLFGLFFGAGNLIFPIFLGQQAGQHVGAAIIGLLITGIGLPLLGVIGMGLTRSQGVFDLATNVSRSYAYVFTVLLYFTLGPLFAMPRLATTAFQIGLAPFLTTKLQPVVLLGFSVAFFVVTWLLARNPGKIMTYVGKWLTPIFLLLLGALMLVAIIKPLGSLNVAASGAYVSHPVLTGFTEGYNTMDALASLAFGIVVIDAIRDLGVRDPGQIATDTIKAGLISMSLMAVIYGLLAIMGTMSLGRFAPAANGGITLAQIADAYFGRFGNVLLALIVIIACLKTAIGLTSAFGDTLHGMFPKISYHWLITIACLIPAILANVGLTEMITYSTPVLMFLYPLAIVLIILAVLAPWLGMSRWLYGMTTVWTMIPAILAGINAMPSAWVQASWLQALLHLNAWLPLANLGLGWSVPALLGFGLGWLISRKQPSASKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE3</accession>
    <name>F9UQE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2009-05" db="PDB data bank">
            <title>Crystal structure of the lp_2219 protein from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Vorobiev S.M."/>
                <person name="Scott L."/>
                <person name="Schauder C."/>
                <person name="Xiao R."/>
                <person name="Ciccosanti C."/>
                <person name="Foote E.L."/>
                <person name="Maglaqui M."/>
                <person name="Everett J.K."/>
                <person name="Nair R."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101686.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889946.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3HFQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.96 A"/>
        <property type="chains" value="A/B=1-339"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HFQ"/>
    <dbReference type="SMR" id="F9UQE3"/>
    <dbReference type="STRING" id="220668.lp_2219"/>
    <dbReference type="DNASU" id="1061488"/>
    <dbReference type="EnsemblBacteria" id="CCC79432">
        <property type="protein sequence ID" value="CCC79432"/>
        <property type="gene ID" value="lp_2219"/>
    </dbReference>
    <dbReference type="GeneID" id="57025742"/>
    <dbReference type="KEGG" id="lpl:lp_2219"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1874"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_3_1_9"/>
    <dbReference type="OMA" id="EGNWPRD"/>
    <dbReference type="PhylomeDB" id="F9UQE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1893-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3HFQ"/>
        </source>
    </evidence>
    <sequence length="339" mass="36539" checksum="BBDCC6DE309D6B90" modified="2011-10-19" version="1">MQERILFGTYTKKTSQGIYQGTLDTTAKTLTNDGLLAATQNPTYLALSAKDCLYSVDKEDDEGGIAAWQIDGQTAHKLNTVVAPGTPPAYVAVDEARQLVYSANYHKGTAEVMKIAADGALTLTDTVQHSGHGPRPEQDGSHIHYTDLTPDNRLAVIDLGSDKVYVYNVSDAGQLSEQSVLTMEAGFGPRHLVFSPDGQYAFLAGELSSQIASLKYDAQTGAFTQLGIVKTIPADYTAHNGAAAIRLSHDGHFLYVSNRGYNTLAVFAVTADGHLTLIQQISTEGDFPRDFDLDPTEAFVVVVNQNTDNATLYARDLTSGKLSLLQKDVTVPEGVCVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG1</accession>
    <name>F9UQG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641560.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889964.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2236"/>
    <dbReference type="EnsemblBacteria" id="CCC79450">
        <property type="protein sequence ID" value="CCC79450"/>
        <property type="gene ID" value="lp_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2236"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1892"/>
    <dbReference type="eggNOG" id="COG4470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080936_0_0_9"/>
    <dbReference type="OMA" id="TEYCNPG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1935-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009370">
        <property type="entry name" value="YutD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038141">
        <property type="entry name" value="YutD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06265">
        <property type="entry name" value="DUF1027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012565">
        <property type="entry name" value="DUF1027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR012565-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="24960" checksum="A41F7B723AD4C91E" modified="2011-10-19" version="1">MNREHIDELAEQQAERRRNLYHGLRTDKTHFEVSKHPFEIVYDYRQGFDLDKFVERYSSILNKYDYIVGDWGFEQLRLKGFFRDDMKDVQRSQTIGAVQDYLYEYCNFGCAYFIIKNERVIKPKRTSRSRKDDRRGKKNTNSRQSRARSNRNSSRSKQRRKSHSFTTKQKAAPFTEKRRQPAKVTAGNGKQAQTTKQSSGKRHFTIRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG8</accession>
    <name>F9UQG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial type II secretion/trafficking system extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for transformation and DNA binding.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644628.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889971.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2246"/>
    <dbReference type="EnsemblBacteria" id="CCC79457">
        <property type="protein sequence ID" value="CCC79457"/>
        <property type="gene ID" value="lp_2246"/>
    </dbReference>
    <dbReference type="GeneID" id="57025794"/>
    <dbReference type="KEGG" id="lpl:lp_2246"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1900"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1684371_0_0_9"/>
    <dbReference type="OMA" id="HQFIVIR"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1942-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0178">Competence</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17666" checksum="06527A7569A07E1B" modified="2011-10-19" version="1">MVVKRQGFTLIETVAVLAIVASVAVIAVHRFPTRQRQQNAEQAFWRELQTMWQQQTLTASVTGQPQVVSFRGTEVVTWGGKRGRPISGPQWHLPLPATLKTERGRDIQIQKNGHPQLAVVIFKSQLQPKQKIKLNALMGWGAYKVTHVKDANGFFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH7</accession>
    <name>F9UQH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="3">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepQ</name>
        <name evidence="3" type="ordered locus">lp_2258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.9" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889980.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2258"/>
    <dbReference type="MEROPS" id="M24.006"/>
    <dbReference type="EnsemblBacteria" id="CCC79466">
        <property type="protein sequence ID" value="CCC79466"/>
        <property type="gene ID" value="lp_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2258"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1909"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_9"/>
    <dbReference type="OMA" id="IHEWPYL"/>
    <dbReference type="PhylomeDB" id="F9UQH7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1951-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="149"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="369" mass="41175" checksum="E3A7CA522BB3881B" modified="2011-10-19" version="1">MTDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAPALEVEAIKEMGWPYKVFGYLDHENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQQFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFAFEQGFAAVKAGRTEQQIAAELQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASRTIAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQTDHEFPSIMAGNHMPLVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKELKVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI9</accession>
    <name>F9UQI9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA2</name>
        <name evidence="7" type="ordered locus">lp_2270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641528.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889992.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2270"/>
    <dbReference type="EnsemblBacteria" id="CCC79478">
        <property type="protein sequence ID" value="CCC79478"/>
        <property type="gene ID" value="lp_2270"/>
    </dbReference>
    <dbReference type="GeneID" id="57025815"/>
    <dbReference type="GeneID" id="66450027"/>
    <dbReference type="KEGG" id="lpl:lp_2270"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1921"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_9"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="PhylomeDB" id="F9UQI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1963-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11296" checksum="D5249AFC673378BF" modified="2011-10-19" version="1">MVAATTDKTFTTDTASGVTLTDFWATWCGPCRMQSPVVEQLADEMGDKVTFNKMDVDANPETASNFGIMSIPTLLVKKDGEVVDTLVGYHSKEQIQQTLAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQK0</accession>
    <name>F9UQK0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="10" type="ordered locus">lp_2281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2281"/>
    <dbReference type="EnsemblBacteria" id="CCC79489">
        <property type="protein sequence ID" value="CCC79489"/>
        <property type="gene ID" value="lp_2281"/>
    </dbReference>
    <dbReference type="GeneID" id="57025825"/>
    <dbReference type="GeneID" id="66450037"/>
    <dbReference type="KEGG" id="lpl:lp_2281"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1931"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_1_0_9"/>
    <dbReference type="OMA" id="KIYKWAV"/>
    <dbReference type="PhylomeDB" id="F9UQK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1973-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="13771" checksum="1EF9154F933A3DB9" modified="2011-10-19" version="1">MGQMASILFIVVMFAFLYFFMIRPQRKQQQQHQQMLSKIKRGDKVTTIGRLHGVVDEVNETEKTVTLDCDGIYLVFDLNAVAKISPAEDAQAKTVAPESGAAAESAATSEVESASSAADDNADSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR03</accession>
    <name>F9UR03_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2b protein 12, endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101793.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890156.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2469"/>
    <dbReference type="EnsemblBacteria" id="CCC79642">
        <property type="protein sequence ID" value="CCC79642"/>
        <property type="gene ID" value="lp_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2469"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2080"/>
    <dbReference type="eggNOG" id="COG1403">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108879_4_1_9"/>
    <dbReference type="OMA" id="KCEEHRR"/>
    <dbReference type="PhylomeDB" id="F9UR03"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2134-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="129" mass="15841" checksum="119580CD92AB2408" modified="2011-10-19" version="1">MAKPMKQCEHPGCRTLVAYDTRYCEKHRKATNKWRYHKRMYDSDESKYQQFYKSSAWRKLSRRFLESNPVCVQCYQDNVIRKANVVDHVIEIKDDWSRRLDESNLQPLCYRHHNRKTRLAREQREQTTK</sequence>
</entry>
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    <accession>F9UR49</accession>
    <name>F9UR49_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase, GGDEF domain</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_2524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890202.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2524"/>
    <dbReference type="EnsemblBacteria" id="CCC79688">
        <property type="protein sequence ID" value="CCC79688"/>
        <property type="gene ID" value="lp_2524"/>
    </dbReference>
    <dbReference type="GeneID" id="57025952"/>
    <dbReference type="KEGG" id="lpl:lp_2524"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2124"/>
    <dbReference type="eggNOG" id="COG3706">
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    <dbReference type="HOGENOM" id="CLU_057684_0_0_9"/>
    <dbReference type="OMA" id="HGAWKDL"/>
    <dbReference type="PhylomeDB" id="F9UR49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2181-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    <dbReference type="Pfam" id="PF00990">
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    </dbReference>
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        <property type="entry name" value="SSF55073"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="396" mass="45818" checksum="88B1F5980452C6D3" modified="2011-10-19" version="1">MLHLLTLSSLGRDLFNIKMLIVILITIGLITLMTILTYLLEQQVHRRQNRYWTIGAHGAEALSVLISMILLRQIFITLNSGSIISWTYATVQLTILLFSLNTMRNLAVEIINLLMPLFIYGQAIWLGHSTQYLPVFLAMAIILISTVVYITHNYQELHATQWKYLLFQILYSGTWWGVIWSVHPFKLSHTLVIILAFVLYMWLIRLAVNRVQKFFNEVLTFDQQVNYDELTGIRNRASFDTHAREVFAAYQHHQMGPVTMVMFDIDHFKAFNDQYGHLAGDAVLRHVAHFVELELNQRSTHGQIFRYGGEEFVIIFRGISALEAGQIMRTIQRKLKTVPIKFNVQTLNVTVSIGISELQPTDQTFTDWFVRVDDYLYQSKQAGRDQTTVESQLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR51</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642738.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2526"/>
    <dbReference type="EnsemblBacteria" id="CCC79690">
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        <property type="gene ID" value="lp_2526"/>
    </dbReference>
    <dbReference type="GeneID" id="57025954"/>
    <dbReference type="GeneID" id="66450242"/>
    <dbReference type="KEGG" id="lpl:lp_2526"/>
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    <dbReference type="eggNOG" id="COG0456">
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2183-MON"/>
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    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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        <property type="entry name" value="Acetyltransf_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="21592" checksum="6A78985DFE733166" modified="2011-10-19" version="1">MITIRPADQDDAGQIAPLINMIFDEMQLEELDDIPEPDLEQAITAAYRTPDYLSGKATTVVAEADGQVVGVAFGYPDKNEDAVDDVLARVTANNDAFGSAFEAEAESYEHEWYLDSIAVDPNYQGHGIGGKLLAALPRYARQAGQKRIGLNVDMANLGAKKLYDRYHYESVGIKPIGDRMYFHMQYELDKDLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642634.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2665"/>
    <dbReference type="EnsemblBacteria" id="CCC79794">
        <property type="protein sequence ID" value="CCC79794"/>
        <property type="gene ID" value="lp_2665"/>
    </dbReference>
    <dbReference type="GeneID" id="57026055"/>
    <dbReference type="KEGG" id="lpl:lp_2665"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2233"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="YNLEHEN"/>
    <dbReference type="PhylomeDB" id="F9URF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2285-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="28518" checksum="A3AEA047D2B523A3" modified="2011-10-19" version="1">MKVFISDDQEQQRLWLNDIITAQLEALHFNYELVSVWQPTDVLAAVKDGGGPNLYFLDIVLQREINGIQLASKIRDYDPDGFIVYVTVRDDMIPDTLSAMTTPTGFISKTNMFDKAKFVPEVQRVLQVVKKRLGMLQQSAEPTLTIRSGALLLTLKLKDIIYCEKEHGLRTTRIVTTTQSYVVHKNLNTIKEQLTAMHFFNEFQSYALNLDHVITVDFNKGVISMDNHDHLTFSRGTIKKLRAYYQTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF7</accession>
    <name>F9URF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101875.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890310.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79796">
        <property type="protein sequence ID" value="CCC79796"/>
        <property type="gene ID" value="lp_2667"/>
    </dbReference>
    <dbReference type="GeneID" id="57026057"/>
    <dbReference type="KEGG" id="lpl:lp_2667"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2235"/>
    <dbReference type="eggNOG" id="ENOG503462T">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2117860_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2287-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13782" checksum="6D4E0B688423C2DB" modified="2011-10-19" version="1">MYEMTKKLRVGDDVKEMIPQAVIAGLWDRLKAMRKEKLLIDSTMAIMFSDDYEDNKIFFMTLQKSGSFANEYEMAYDGPKDFLGHGTIVIIKDRPRTIQMSISDANKAEDTNDDATDEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG0</accession>
    <name>F9URG0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transport protein with CBS domains, DUF21 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">lp_2671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101876.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890313.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URG0"/>
    <dbReference type="STRING" id="220668.lp_2671"/>
    <dbReference type="EnsemblBacteria" id="CCC79799">
        <property type="protein sequence ID" value="CCC79799"/>
        <property type="gene ID" value="lp_2671"/>
    </dbReference>
    <dbReference type="GeneID" id="57026060"/>
    <dbReference type="KEGG" id="lpl:lp_2671"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2238"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_9"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="PhylomeDB" id="F9URG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2290-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="455" mass="51780" checksum="EB9562C4FB2011E6" modified="2011-10-19" version="1">MDSGQIILNLVIIVITFFVAAFFVACEFALVQTRPSALEEEQKKRDKPSKRIATSLHMVRNLNEYLSTTQVGVSLAGIILGWIGEQTTEHFVLDFLSLFNLSVSTAVLRGISIVIGVFLLTYLEVVLTEIVPKNIAIDMPLKVMAVITTPLRWFHVMFYPFVWLLNVSSAGVVKMLGIPVANEDNDVYSQAEILNLSRNAVTGGELERNDYLYMERAFEFNDKIAKDIMIDRTQLVVIDINDTVKQAIRVYLQKRFSRLPVVANNDKDKILGYVYNYDLIRQGEVDDDIRVNKLLRNIITIPETTPIQAILQKMIDKQTPIVVVVDEYGGTSGIVTDKDIYEELFGTVNDEIDNVSNEYIEKQADGTYRISGKMTIYDFERYFKTDLQEFEDSDVVTLTGYILDNFPKIQAGDTIQIGNFNFKALDFENAYINWFEVSAQRDSTPDDHNDDQTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM8</accession>
    <name>F9URM8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltogenic alpha-amylase</fullName>
            <ecNumber evidence="2">3.2.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.133" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890381.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URM8"/>
    <dbReference type="STRING" id="220668.lp_2757"/>
    <dbReference type="CAZy" id="CBM34">
        <property type="family name" value="Carbohydrate-Binding Module Family 34"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79867">
        <property type="protein sequence ID" value="CCC79867"/>
        <property type="gene ID" value="lp_2757"/>
    </dbReference>
    <dbReference type="GeneID" id="57026128"/>
    <dbReference type="KEGG" id="lpl:lp_2757"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2307"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_2_9"/>
    <dbReference type="OMA" id="TPDWVKH"/>
    <dbReference type="PhylomeDB" id="F9URM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2358-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043897">
        <property type="term" value="F:glucan 1,4-alpha-maltohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="142"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="574" mass="64395" checksum="53A0B8755E61B197" modified="2011-10-19" version="1">MQLAGIRHRPESEDTAVLAAHQLQVRLQTARDDVAQVEILFADSYLWQEGTTALERRIMQPGLATQGNQYWQTTLTVPTNRVVYAFLITDTIGATVGYGEGGFFDDVATNWQTVGNYFHMPYMHVSDAELPPAWVKETVWYQIFPERFANGVRQNDPANVQPWGAGRVHRDSFYGGDLPGITAHLDDLAALGVNGLYLCPIFTSPSNHKYDTIDHFEIDPHFGTKADFQALVDGAHARGMRVMLDAVFNHFGEQSPQWQDVIKNGEQSRFADWFHIHGWPVGRDPKTKRLNYETFATGAAMPKVNTQNPAVQAYLIDVTKYWIEQFGIDAWRFDVADEVDHGFWRALCGALRAIKPDVYLLGESWHSSQSLVGNGQFNAVMNYPLTQPILALFNGQLNPEDYVGKTNLELMMYRQPNQQAMFNALDTHDTPRLLTTLHGQLTKFKSALTLLMLLPGSPCIYYGTEVAMAGGADPDNRRCMNWQPDEQEQQVRQFVTRLIKFRRQQADFLATSQLTWTIDGHCLILTRTDVEQTIQGRFNLGAQAVSTVSGVSPILTAGITANEMAPGGFELTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU1</accession>
    <name>F9URU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC79930">
        <property type="protein sequence ID" value="CCC79930"/>
        <property type="gene ID" value="lp_2836"/>
    </dbReference>
    <dbReference type="GeneID" id="57026195"/>
    <dbReference type="GeneID" id="66450470"/>
    <dbReference type="KEGG" id="lpl:lp_2836"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2372"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="GNICYGA"/>
    <dbReference type="PhylomeDB" id="F9URU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2427-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EmrB-like"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="494" mass="53928" checksum="69AC22FBE7E548EF" modified="2011-10-19" version="1">MPTQNSTLPLDANGQPYHRTWLVLTLLVGTFTTFITQTLLTTAFPTLMADFHISATAVQWLTTGFMLIMGIMIPVSAWLLTRINSKYLYLTAMLIFGLGTTLAYFAVNFQMLLIARMIQAMGVGISAPVFQTIMSSVYPPEKRGSAMGTAGIVIGLAPAIGPTLSGWIIDNYSWRALFLFILPINILVIIVSFFTLRKVLPTSKQPIDWWSVLISTIGFGSMLYGFSSVGNAGWGDPVVLTTLVIGLIFIGLFVWRQLHMDQPLLELRVFKIPAFTLSAILTALAYMAMMGVEMILPMYIQTVLGRSAMDSGLILLPGAIMMGIMSPITGRIFDHIGARRLAMTGMLLLTLGTAFFLSISATTPILWIIVVYAIRMFGLTMVTMPVTTTGINALPFRLISHGTAANNTLRQVAASMGTAVLISVYSSVAKWQMPGHQLLTQAPLKYRQDGITATLTGYHMAFVVSLIFCAIGFGITFFLKANHSKTISQEDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV9</accession>
    <name>F9URV9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, ATP-binding protein,C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890462.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2857"/>
    <dbReference type="EnsemblBacteria" id="CCC79948">
        <property type="protein sequence ID" value="CCC79948"/>
        <property type="gene ID" value="lp_2857"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2857"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_21_9"/>
    <dbReference type="PhylomeDB" id="F9URV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2445-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="134" mass="14556" checksum="D7859757DB343326" modified="2011-10-19" version="1">MTARENVELASQITKDARDVDETLALVGLTHRADNFPAQLSGGEQQRVAIARAVAKNPKLLLCDEPTGALDYQTGKQVLQVIQDAAKQTQTTVIIVTHNSAIAQLGDQVIRINDAQVQSVEHNAHPTPLAEIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX5</accession>
    <name>F9URX5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890478.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79964">
        <property type="protein sequence ID" value="CCC79964"/>
        <property type="gene ID" value="lp_2876"/>
    </dbReference>
    <dbReference type="GeneID" id="66450504"/>
    <dbReference type="KEGG" id="lpl:lp_2876"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2407"/>
    <dbReference type="eggNOG" id="ENOG502ZGN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632580_0_0_9"/>
    <dbReference type="OMA" id="IIFPNEL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2461-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="73" mass="8207" checksum="2DB1DD2251016B59" modified="2011-10-19" version="1">MEVSIRKIGNAQGIIFPNELNLEVGARYRIEQSGPALIMTPINSELFANPDDWVGFRDSISQADREWDQLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9US32</accession>
    <name>F9US32_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890535.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2954"/>
    <dbReference type="EnsemblBacteria" id="CCC80021">
        <property type="protein sequence ID" value="CCC80021"/>
        <property type="gene ID" value="lp_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2954"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2465"/>
    <dbReference type="eggNOG" id="COG3641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063648_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9US32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2517-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="364" mass="37511" checksum="895EC59536BFD15D" modified="2011-10-19" version="1">MEATTTAATATHKMSTMDYVYKVSAGVSNAILVCLGIGLLLQSLANFVHWTALYQVGAIAQVLLGPAFGVAIATMLNSNTLVTFSAMISSTIGANAVFFSQSATNGVTATGHTLAQAAQSSIFTTGQPISAVAAGLVAVLIGNYLTGKTPLDMMLVPLAATFVGAVVGLGLAAVTTPALVWLSKFIATSMKVNPLIGSMAVSLAWALFLMTPASSAALAVAVMLDPVSSGAALIGTTAQFVGFTIMSFRQNNLGANIAQGIITPKVQFPNLLVNPRLAIPPMVAAVIAAPVATIAFHFSTSYKLAGLGLNSLIAPISLASTNFNSFMVYLLTGVLMPAVISIVLYRILVAAKWVESQQLQLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9US93</accession>
    <name>F9US93_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">wapA</name>
        <name evidence="10" type="ordered locus">lp_2958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101980.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890537.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2958"/>
    <dbReference type="EnsemblBacteria" id="CCC80023">
        <property type="protein sequence ID" value="CCC80023"/>
        <property type="gene ID" value="lp_2958"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2958"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2468"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030562_0_0_9"/>
    <dbReference type="OMA" id="VANEANM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2519-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008456">
        <property type="entry name" value="Collagen-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041171">
        <property type="entry name" value="SDR_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17961">
        <property type="entry name" value="Big_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05737">
        <property type="entry name" value="Collagen_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388990" evidence="7">
        <location>
            <begin position="32"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Big_8" evidence="9">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_bind" evidence="8">
        <location>
            <begin position="171"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="617" mass="64873" checksum="262EDDE46D064BF0" modified="2011-10-19" version="1">MKLSKRGLFWLLGLVSFAILLLFSQPLGAQAATNYHAKDYTTAASVINGPDFKHADTIQIQYQMSFGDTTFKAGDTVTIDMPANLEPRTVGATFDVTDAETGTVIGTGVVGGDGQVVLTMNSAIEGKTNVKIDVNLGMKYRYDDLGEQDVVFDTQDGQDTSVINMVANEANMSKKGTIDKENGTIKWTLLVDRREITMKNLSIADTIGDHQQMIKGIEVYNGEWSSANTYKRRDKLSDDAYQVNYSDNGFDLKFNDTVSNLVVIDYYTKITDTELIDQNYHFKNKAVMEWGGGTSGGKNSEEANGKVYEKVVNGGSGTGDLSSSSSSNSSSSNNSSDVDSSSDDSNSESSSAVDSSSDDSSSESSSAVDSSSDHSSSESSSAVDSSSDDSSSESSSAVDSSSDHSSSESSSAVDSSSDHSSSESSSVVDSSSDHSSSESSSAVDSSSDHSGSESSSDVNTSSESSDNTTTEPDNGHQTGDIEDPEDNTAVYPDIDEDTGTIDVDGGFDSNYDGSTTSNSTNSSKPLKDSTSSVFTSTPANTTTGQDGVDQTPAADTKKSSAKTTVSESDALTPSTPNQVAKLPQTNEAKMDSQALRSVGILLGVLTLGGGALIRHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9US99</accession>
    <name>F9US99_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional protein: transcription regulator sugar kinase, ROK family</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80029.1"/>
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    </dbReference>
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    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="PhylomeDB" id="F9US99"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="ROK"/>
    </dbReference>
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        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="31650" checksum="94ECB1199D1EE860" modified="2011-10-19" version="1">MQSLGVIDIGGTTIKFAVWQDQQLVAKTKVTTPTTLAEFYTLLTTQVAQMKRDYQIAGVGISSPGAVNKATGIIEGASALPYIHNFRIQPELQRRFELPVSMENDANCAALAELADGAGKQVASLCFLIVGTGVGGSVIVNHQIWHGAHLFGGEFGFTLMNDHQILSELGTAVAVAKRYNASHPAQPELDGQAVFELAAKGDTDAQAEVQVMVRALARAIYNLQYSFDPELIVMGGAVSNNPHLLPAINAEIEKLRATVKIASITPDVVACHFTDEANLRGAVVDFCQTYLDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA0</accession>
    <name>F9USA0_LACPL</name>
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        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890544.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2966"/>
    <dbReference type="EnsemblBacteria" id="CCC80030">
        <property type="protein sequence ID" value="CCC80030"/>
        <property type="gene ID" value="lp_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2966"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2475"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="ERQRMTI"/>
    <dbReference type="PhylomeDB" id="F9USA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2526-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="274"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="313"/>
        </location>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
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            <end position="386"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="585" mass="63996" checksum="3A5F0EA3D9713A56" modified="2011-10-19" version="1">MERPQAAYSRPAGGKFDLKQFLQLIRHASPRYWQLWLGLALGLLATGAQLMVPKFAQTLINGFSHGVNQTLLIGVIGLFLISAVISALSGSLLGIFGENVVANLRGTLWHKLVRLPVRYFDNVKTGEMTSRLVNDSTQIKDLLANAFPQVVTSLMQLVGAIAIMVLMDWRMTLIMVLAIPVVLLVMFPIMRQTGKIGHERQDALANFSGTAEETLSEIRLVKSSNAEPVETTTGAHQIKTLYRIGLREAIYDSISSPVMTATMMALFVGVLLYASARVASGTMTMGTLVSFLMYLFQIIGPAGMLGQFFTTLAKASGSTARIRELLNEPEEQLTVGVEHAVANETLAMHHVDFAYDDDQQILHDVSFEAKPNTVVAFAGPSGGGKSTIFGLLERYYQPTAGEISIGGQDVNELSLNSWRSQIGYVSQDSAIMAGTIRQNLTYGADRLYSDNELWHVLELASAADFVRAMADGLETQVGERGVKVSGGQRQRLAIARAFLRDPKILMLDEATASLDSESEAMVQQALGELMKGRTTLVIAHRLSTIVDADQIYFIEDGHVSGSGTHQELMANVPLYRDYVKIQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC0</accession>
    <name>F9USC0_LACPL</name>
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        <submittedName>
            <fullName evidence="8">Teichoic acid glycosylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gtcA3</name>
        <name evidence="8" type="ordered locus">lp_2989</name>
    </gene>
    <organism evidence="8 9">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890564.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2989"/>
    <dbReference type="EnsemblBacteria" id="CCC80050">
        <property type="protein sequence ID" value="CCC80050"/>
        <property type="gene ID" value="lp_2989"/>
    </dbReference>
    <dbReference type="GeneID" id="57026321"/>
    <dbReference type="KEGG" id="lpl:lp_2989"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2495"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_1_1_9"/>
    <dbReference type="OMA" id="WATANIV"/>
    <dbReference type="PhylomeDB" id="F9USC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2545-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18394" checksum="621356B819254400" modified="2011-10-19" version="1">MSKPDSIKVDQNEETVTEILEPAAELDKKIISPVKETRNQAIRYILWGLISVAVNFATFYTMYHLIGLEYQVANVISWVIAVQVAFWVDRLKVFDHHSHHVYREMGKFYATRIVTYVVEAIILWLLMSVLGSSAVLAKILGQAGAIIGNFLFSKLYVFRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC3</accession>
    <name>F9USC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2993"/>
    <dbReference type="DNASU" id="1063472"/>
    <dbReference type="EnsemblBacteria" id="CCC80053">
        <property type="protein sequence ID" value="CCC80053"/>
        <property type="gene ID" value="lp_2993"/>
    </dbReference>
    <dbReference type="GeneID" id="57026324"/>
    <dbReference type="KEGG" id="lpl:lp_2993"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2498"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="HAKISSM"/>
    <dbReference type="PhylomeDB" id="F9USC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2548-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="143" mass="15724" checksum="71665EE490F8071F" modified="2011-10-19" version="1">MATKFNRILVGVDDSADALLAFDYAIHQAKQDGAELVIISILENDEMNVYQALSKDYIHGERQELEQHILKYQKQAQAAGVTKVHAMIAEGEPGETIVKEVIPHVQPDLLIIGSLAKKGIAKHFGSQAAYMAKYAPISVLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL4</accession>
    <name>F9USL4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642346.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3100"/>
    <dbReference type="EnsemblBacteria" id="CCC80144">
        <property type="protein sequence ID" value="CCC80144"/>
        <property type="gene ID" value="lp_3100"/>
    </dbReference>
    <dbReference type="GeneID" id="57026410"/>
    <dbReference type="KEGG" id="lpl:lp_3100"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2590"/>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_8_1_9"/>
    <dbReference type="OMA" id="VVYAWVM"/>
    <dbReference type="PhylomeDB" id="F9USL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2637-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="317" mass="35501" checksum="794010E60207D3C1" modified="2011-10-19" version="1">MKTIQIGASQLKASAVALGIMRMVRLDTDAAANVLETVHDRGVNFIDSADIYGNGDSERIFGQALKQSSLKREDFFIQSKGGIVLDPEKSSGELVFGQRYDFSKQHLIATVDKILQRMQLDYLDSFLLHRPDPLMDPAEVAAAFDELQATGKVRHFGVSNFNPMQVEMLQAAVSQKLMINQLQFGVMHTGPIQFGLHTNMQDTASLNHDGEIIEYSRLHHMTIQAWSPYQYGMFAGTFIDNPKFPELNAKLQELADQYHVTKNAIATAWILRHPANMQVILGSMNPQHLDESIAGTDVTLTRQEWYDVYFAAGNDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP6</accession>
    <name>F9USP6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar-specific permease, SgaT/UlaA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77693.1"/>
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    </evidence>
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    <sequence length="505" mass="59042" checksum="1A84293E677373D2" modified="2011-10-19" version="1">MPAATTLITPAENRFFLLSERARRRTTLQQISALLRAHVTVKADSDFLKPTVRNLILQDHAQWLTDCSHEWQLLASLPYVVNPNESRQAWHHCELCHKPVRYEYHVQNKHNHRELIVGSECVKKFMNAETRYLMVITTEDNFYAVAQYQTLTTAVPTVPTIMFAQPWLPQLPAEQAPQARKLRQTTTQTVTTYLKRRTKQLPLQELKPAEQTYQRLVHDEQTVIEAAERAARQAIVTNQQQRQAQAQQSAVKAEQTLRQSHAYQCYLQQLAAIIVMRPERPMAKQQFEKITPPATERPLVNSYQFGQMVTEYRQTGKIQVRRLAMLDHQFVAALNQVTQQLDEQQTTRFYDDVFNSCWGWQYHQQATQRADWEHLLTTRWGQSLSLAWFEQLAMQTTMPQTQQWLADNADAGMQAALQQRLAAHEDRQPIARDRMTRSELRQFCLREQPAAPTLEAFEQVFDQQYQLSVDRQATAHETLAYYYIARQYQGDHQRALQQLNWLLKV</sequence>
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    <accession>F9USW4</accession>
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        <submittedName>
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    <organism evidence="7 8">
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        <lineage>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="279" mass="32063" checksum="7C7BB50093BEBF82" modified="2011-10-19" version="1">MQHELLIGYNDRHTFLNRLSGSTKLLCFVGLSVIGMMTYDTRYLIGVMIFSLILFRFSKIHYRDIAFVLNVIIGFSVLNLVMVYVFAPHYGVSIYGTEHLLLGSADHYFNLTAEQLFYEFNLLLKYTFAVPLALIFLMTTNPSEFAASLNKIGISYRISYSVAIALRYIPDVQADYRTISLAQQARGFEMSKKAHFMTRIRGGIQILLPLIFSSLDRIETISQAMELRRFGKGKHRTWYMAQRFKRNDYLALTLVALLIILGIALFKVNGGRFWNPFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9USW7</accession>
    <name>F9USW7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0152"/>
    <dbReference type="EnsemblBacteria" id="CCC77698">
        <property type="protein sequence ID" value="CCC77698"/>
        <property type="gene ID" value="lp_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0152"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.123"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_0_9"/>
    <dbReference type="PhylomeDB" id="F9USW7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-120-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="26682" checksum="5D768C3BD747333D" modified="2011-10-19" version="1">MAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAIQLLIIEGMVYSKRGAGTFVRKDFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARLPTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPTSIVTLTKQVLEGSVYGYLEQHSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYETSTVVADVQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT87</accession>
    <name>F9UT87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfa2</name>
        <name evidence="3" type="ordered locus">lp_3174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890719.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3174"/>
    <dbReference type="EnsemblBacteria" id="CCC80205">
        <property type="protein sequence ID" value="CCC80205"/>
        <property type="gene ID" value="lp_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3174"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2653"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_9"/>
    <dbReference type="OMA" id="LDPTMMY"/>
    <dbReference type="PhylomeDB" id="F9UT87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2693-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="45295" checksum="BDECFC1D3D07DDB9" modified="2011-10-19" version="1">MLEKTFYHTLLSHSFNMPVTVNYWDGSSETYGEGTPEVTVTFKEAIPMREITKNASIALGEAYMDGKIEIDGSIQKLIESAYESAESFFNNSKFKKFMPKQSHSEKKSQQDIQSHYDVGNDFYKMWLDPTMTYSCAYFKHDTDTLEEAQIHKVHHIIQKLNPQPGKTLLDIGCGWGTLMLTAAKEYGLKVVGVTLSQEQYNLVAQRIKDEGLSDVAEVRLQDYRELGNETFDYITSVGMFEHVGKDNLAMYFERVNHYLKADGVALLHGITRQQGGATNGWLDKYIFPGGYVPGMTENLQHIVDAGLQVADVETLRRHYQRTTEIWDKNFNAKRAAIEEKMGVRFTRMWDLYLQACAASFQSGNIDVMQYLVTKGASSRTLPMTRKYMYADNRINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT99</accession>
    <name>F9UT99_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hpk11</name>
        <name evidence="11" type="ordered locus">lp_3190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890731.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3190"/>
    <dbReference type="EnsemblBacteria" id="CCC80217">
        <property type="protein sequence ID" value="CCC80217"/>
        <property type="gene ID" value="lp_3190"/>
    </dbReference>
    <dbReference type="GeneID" id="57026479"/>
    <dbReference type="KEGG" id="lpl:lp_3190"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2665"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="OMA" id="RRFEVWP"/>
    <dbReference type="PhylomeDB" id="F9UT99"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2705-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="156"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="386" mass="43739" checksum="08CFB5EBCDCDDFC4" modified="2011-10-19" version="1">MKLTGREKSELFFEGVVTVILLLLLNLSIVVLINSTIAHNPGLQSGIFQIKRSITIGPNNYQLWSYENIFIGLMLIADGFVLYWRLIRRYKQMQLRHIISELHYIAAGHFDHRIDFNLTGDTQRVVESVNALVDSAIHSMDEEREIERSKDALITNVSHDIRTPLTSIIGYLGLIENKQYQSEEDLIKYAHIAYLKATQMKSLVEDLFEYTKSRQTETPLAINRLNLTAMLEQLAASFELEANKKHLKIEVESGTQPIYIEADAEKLGRVFSNLITNAFKYGTGAKNVVLQAEQRGEEVVIHVTNDGQRIPAESLGRLFERFYRVEESRSKATGGSGLGLAIAQSIVDHHGGYIYAQSDDEQTSFVIHLPVKHDHPLTKKQSDMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA5</accession>
    <name>F9UTA5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">lp_3196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642429.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890737.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3196"/>
    <dbReference type="EnsemblBacteria" id="CCC80223">
        <property type="protein sequence ID" value="CCC80223"/>
        <property type="gene ID" value="lp_3196"/>
    </dbReference>
    <dbReference type="GeneID" id="57026485"/>
    <dbReference type="GeneID" id="66450745"/>
    <dbReference type="KEGG" id="lpl:lp_3196"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2671"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_9"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="PhylomeDB" id="F9UTA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2711-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="39893" checksum="6EFBE6DA15C30971" modified="2011-10-19" version="1">MALTAGIVGLPNVGKSTLFNAITKAGAEMANYPFATIDPNVGMVEVPDKRLDRIQEIIPAKKVVPTTFEFTDIAGIVKGASKGEGLGNKFLENIRQVDAIVHVVRAFDDDNITHVTGKVDPQDDIETINLELSLADLEAVDKRLAKVQRAAKGSDKEAKAELAVLQKIKPALEAGKPVRSLEFNEDDQQIVKGLFLLTSKPVLYVANIAEDDMADPENSKYFQVVADYAKQEGAQAIGVAAETEEEIAELDDDDKADFLAAEGVEEPGLNKLIRASYKLLGLETFFTAGGKETRAWTFKRGTKAPQAAGIIHSDFERGFIRAEVMSYDALDEAGSEAKVKENGKLRLEGKDYVMQDGDIVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB5</accession>
    <name>F9UTB5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystine ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642439.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890747.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3209"/>
    <dbReference type="EnsemblBacteria" id="CCC80233">
        <property type="protein sequence ID" value="CCC80233"/>
        <property type="gene ID" value="lp_3209"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3209"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2681"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_9"/>
    <dbReference type="OMA" id="WFGIDVS"/>
    <dbReference type="PhylomeDB" id="F9UTB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2721-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389127" evidence="4">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="44"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="28968" checksum="0150C1898632D8E5" modified="2011-10-19" version="1">MKSWVKKLSVAVLGLGLAVTLTACGSNTSSSSKSNDLGLQKSGTLTIGLEGTFQPYSYRKDGKLTGFEVDLGKAVAKKMGLKAKFVPTKFDSLVAGLDTNKFDVVMNNMSETAARKKKYLFSTPYIYSKSQLAVKKNSSISKITDIKGKKVAETTTSNNATDAKRLGATITPTDSFQQSIDLVSQGRVAGTINSRESFYAYFKQNPKANIKLIDSGDHIASQKIGAIVTKQHPKMQKQISKAIQELRKDGTLKKLSNKYFGGNVTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD0</accession>
    <name>F9UTD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642455.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3227"/>
    <dbReference type="EnsemblBacteria" id="CCC80248">
        <property type="protein sequence ID" value="CCC80248"/>
        <property type="gene ID" value="lp_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3227"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2696"/>
    <dbReference type="eggNOG" id="ENOG50311TG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1747302_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2736-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16776" checksum="25326996E969C937" modified="2011-10-19" version="1">MAATDSQIALTMTFTLRPPFKTHFLLLKDYVADVRIPARDGMLTTIIAKNIPLSPALEQLKTIFDDVQNPVYWRLHDQAVQEFFSAHPEQRPVLPIDLLQVMLNTLSAQGLSDQQLMHIMKDVFERLQTNDFNGQASQRILTSLNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ5</accession>
    <name>F9UTJ5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pflB</name>
        <name evidence="18" type="ordered locus">lp_3313</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890827.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3313"/>
    <dbReference type="EnsemblBacteria" id="CCC80313">
        <property type="protein sequence ID" value="CCC80313"/>
        <property type="gene ID" value="lp_3313"/>
    </dbReference>
    <dbReference type="GeneID" id="57026577"/>
    <dbReference type="GeneID" id="66450841"/>
    <dbReference type="KEGG" id="lpl:lp_3313"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2764"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_9"/>
    <dbReference type="OMA" id="PYGGIKM"/>
    <dbReference type="PhylomeDB" id="F9UTJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2804-MON"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="17">
        <location>
            <begin position="5"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="16">
        <location>
            <begin position="629"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCC80313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="752" mass="84480" checksum="52AF3BDA563256F9" modified="2011-10-19" version="1">MITSEKTTKPAAWKGFKGGHWQEEINIRDFIQNNFTQYNGDESFLAGPTAATKTLNDKVLELKKQERAAGGVLDADTKVVATITSHGPGYIQKDLEKIVGLQTDKPLKRAFMPFGGIRMADDALKSYGYTPDEENDKIFTEYRKTHNQGVFDVYTPDMRKARHYKIITGLPDAYARGRLIPDLPRVAVYGIDRLMEDKANDFAHIGDGELTDDVIRLREEVQDQYRALADMKKMAASYGYDISKPATNAQEAIQWMYFAYLAAIKTQNGAAMSVGRIDTTMDIFIQRDLDNGVLDESQAQELIDQFVMKLRMVRFIRTEEYNSLFSGDPIWATLSMCGLGVDGQHHVTKTAFRILKTLDNMGAAPEPNITILWSDRLPEDFKRYATEVSIDSSTIQYENDDLMRVQWGTDYYGIACCVSAQPIADGIQYFGARANLAKAILYAINGGRDEIAGDQVGPAYEPITSEYIDYDEFMKKLDKQMDWLADTYVNSLNAIHYMHDKYYYEAAQLALKNTDLDRTFATGISGLSHAADSISAIKYGHVKVIRDERGIAVDFKADNDYPRYGNNDDRADDIAKWLVKELYSKMNTHHLYRNAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPAYGAEKSGALASLLSTAKLPYRYATDGISNTFGVTPNTLGHDLESRKDTLVNMLDGYMKNDGMHLNINVFNKDTLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVISRTFFESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN7</accession>
    <name>F9UTN7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641856.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888321.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0281"/>
    <dbReference type="DNASU" id="1061164"/>
    <dbReference type="EnsemblBacteria" id="CCC77807">
        <property type="protein sequence ID" value="CCC77807"/>
        <property type="gene ID" value="lp_0281"/>
    </dbReference>
    <dbReference type="GeneID" id="57027094"/>
    <dbReference type="KEGG" id="lpl:lp_0281"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.234"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_3_9"/>
    <dbReference type="OMA" id="HKQKEFI"/>
    <dbReference type="PhylomeDB" id="F9UTN7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-229-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="14870" checksum="857B15B4E07D5037" modified="2011-10-19" version="1">MFTITATAQKYGVSNNALRYYESVGLIGPIKRDQNGIRQFSASDQEMVNRIVHLRQLGASIKEIQQYSFRPEEVTLERTVALKKFLLRLNGDLEAQEAQIKIEKQYLKAKIEHLDGDILSMKSHKTTQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS4</accession>
    <name>F9UTS4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641896.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0320"/>
    <dbReference type="EnsemblBacteria" id="CCC77844">
        <property type="protein sequence ID" value="CCC77844"/>
        <property type="gene ID" value="lp_0320"/>
    </dbReference>
    <dbReference type="GeneID" id="57027134"/>
    <dbReference type="GeneID" id="66448414"/>
    <dbReference type="KEGG" id="lpl:lp_0320"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.272"/>
    <dbReference type="eggNOG" id="COG4405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102450_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTS4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-266-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06553">
        <property type="entry name" value="ASCH_Ef3133_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="PTHR39203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021320">
        <property type="entry name" value="DUF984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="17167" checksum="A5E6615338DF4DD8" modified="2011-10-19" version="1">MPAQSAEQLWHAYNESTDTNGASYQTRWFGQQNNPAEVTALADAILAGTKTATTTPLDSYTAEQIAIPQVGDYNVLLNGDMKPVAILKTVVSELIPFYRISAEHAYHEGDGDRTIGDWRKRKTAEFTPTLEEHGKNLSSDTPMVSEVFEVVYRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT0</accession>
    <name>F9UTT0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoin ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641902.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888364.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0327"/>
    <dbReference type="EnsemblBacteria" id="CCC77850">
        <property type="protein sequence ID" value="CCC77850"/>
        <property type="gene ID" value="lp_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0327"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.278"/>
    <dbReference type="eggNOG" id="ENOG50309QZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833635_0_0_9"/>
    <dbReference type="OMA" id="GASIHHW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-272-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="37824" checksum="55F0407DB11BD468" modified="2011-10-19" version="1">MTKRKLWQLLWRHYRTLLLTAGGVLLLVGIKEGYSIAHNPSRYVAQNVSSFALMEATHLRMETVVAIIVSLVLGVALFLSDNFTNFNQYLFSLPVARKQIYRRKIGLLIGMLVSAYMLAEAVFGLIAWRVLAKQQVRIDWLTTLYEELGILAVMLVFGLLAATFGLWVGHIFASALATFVFVCSLPFAYDGLINLAAGLTKLKYEQVDVLGQLPSWKPGGLLTTWVICGVIGGGLYLLNRWAFEHLSLENSGDFFRFPQWRGAVLGFSIIYLIVAICCSQFGNGVLGLLTDNYHAHMPLSTGIIMALVVAYLTWSLGRWFLYRPDRFRDAWTVKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV3</accession>
    <name>F9UTV3_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">lp_0355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641930.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888387.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTV3"/>
    <dbReference type="STRING" id="220668.lp_0355"/>
    <dbReference type="EnsemblBacteria" id="CCC77873">
        <property type="protein sequence ID" value="CCC77873"/>
        <property type="gene ID" value="lp_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="57027164"/>
    <dbReference type="KEGG" id="lpl:lp_0355"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.300"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_2_0_9"/>
    <dbReference type="OMA" id="GMWIIED"/>
    <dbReference type="PhylomeDB" id="F9UTV3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-295-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="346"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="501" mass="56846" checksum="1EE2DDC5F3BF338E" modified="2011-10-19" version="1">MAKKVYTDYFFDEPAYNTHDGGYIPLVTPKVEPQPLAIPPLLKPDRQTDTDDYYTVTAQESETQFLPGKKTKTWGYNAGFLGQTIVFRNGKQTHIDLENKLPELTTFHWHGLNVPGPITDGGCHAPVYPGETNHIDFKVHQPAATTWLHAHPCPSTATQVWKGLATMVIIKDDVEDQLPLPRNYGVDDIPLVLQDREFHDDNQFDYRADYDPDGVQGHTALVNGTVNPYFDVTTQRVRLRILDGSNRREWRLHFNDDLEFAQVASDGGILPAPVYMTKVMMTCAERDEIVVDFGQYQPGDEVTLMTDDTPLCRFRIKSFVPDDTKLPEHLVDIPDETPTPDLPVRTITMDGMDDEVALDGKKFDMSRIDARQKVGDVAIWEIRNTNSTENGMVHPFHVHGTQFRVLARNDGPVYPNEHGLKDTVGVNPGETVRIKVKFELTGVYMYHCHIIEHEDGGMMAQIESYDPQHPQTYHLMDMDTLRNAFAKEQGIKPEDVWMPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV6</accession>
    <name>F9UTV6_LACPL</name>
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        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0359</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0359"/>
    <dbReference type="EnsemblBacteria" id="CCC77876">
        <property type="protein sequence ID" value="CCC77876"/>
        <property type="gene ID" value="lp_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="66448451"/>
    <dbReference type="KEGG" id="lpl:lp_0359"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.303"/>
    <dbReference type="eggNOG" id="COG1419">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-298-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="45646" checksum="93210CE8CFAC620D" modified="2011-10-19" version="1">MSSTISAATFKLNDQAALSPAQQSLEHQLLTFIRTHRQQKQPSLFVIHGDAGTGKSAVLAAAFARLQALNRSLTPNDLQATDNYLVVNHNEMLKIYKRLAGEDPVLRKKDFQKPTPLINRLAKEHRQADVVFIDEAHLLLTQPDRYNRFTGHNQLTELINHSRVVVLVFDTRQVLKLKSYWHSNDLKPFLDQYPHANYNLDEQFRVTGGADVVDWIDGFTRGQLQPKPVSDNFDLRFFDDGQPLYDLIKQRDQQYGLARMVATADFPYVVNHGTWYVTAGQLKLPWDKVNLTDDPWALRPETLNEVGSIYTIQGFDLNYAGVILGPSVGYDEDHDRIVVRPERYEDQEAFKNRTDLGDLRPLKQQIIFNSINVLMKRGRYGLYIYAVDPALRQRLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ1</accession>
    <name>F9UTZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888425.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77911">
        <property type="protein sequence ID" value="CCC77911"/>
        <property type="gene ID" value="lp_0402"/>
    </dbReference>
    <dbReference type="GeneID" id="57024210"/>
    <dbReference type="KEGG" id="lpl:lp_0402"/>
    <dbReference type="eggNOG" id="ENOG5030AV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2807087_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-334-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7583" checksum="29881217154CACD6" modified="2011-12-14" version="1">MEEIISFEFSNGSKLLDSNVYEYKVGKEGTIKIDFPDSNGFVAVHKNNTETAYIKAPYMKFCTGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU63</accession>
    <name>F9UU63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3380"/>
    <dbReference type="EnsemblBacteria" id="CCC80365">
        <property type="protein sequence ID" value="CCC80365"/>
        <property type="gene ID" value="lp_3380"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3380"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2816"/>
    <dbReference type="HOGENOM" id="CLU_3008664_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2853-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="58" mass="6940" checksum="56CC0F273DC1D820" modified="2011-10-19" version="1">MQIERFWEVFHGQDLDRLVDKAHEDAPLSSEVYQVQVKYLNNEYVLTAIYEHEVNVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA6</accession>
    <name>F9UUA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_3427a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3427a"/>
    <dbReference type="EnsemblBacteria" id="CCC80408">
        <property type="protein sequence ID" value="CCC80408"/>
        <property type="gene ID" value="lp_3427a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3427a"/>
    <dbReference type="HOGENOM" id="CLU_2437151_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2896-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="10497" checksum="B351DE3A6FFC9DEE" modified="2011-10-19" version="1">MKLITVEEHFESAAVTAAMRQAVGNAALPTVSPALRQYMRDNLPSLQLCKTPSMNAWHLWLNRALICRCYLMVIHHHRTYRRNKQFHSHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RX1</accession>
    <accession>F9ULM8</accession>
    <name>YIDC2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC2</name>
        <name type="ordered locus">lp_3687</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641627.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891149.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RX1"/>
    <dbReference type="SMR" id="Q88RX1"/>
    <dbReference type="STRING" id="220668.lp_3687"/>
    <dbReference type="EnsemblBacteria" id="CCC80635">
        <property type="protein sequence ID" value="CCC80635"/>
        <property type="gene ID" value="lp_3687"/>
    </dbReference>
    <dbReference type="GeneID" id="57026861"/>
    <dbReference type="KEGG" id="lpl:lp_3687"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3079"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_5_0_9"/>
    <dbReference type="OMA" id="WIMPIMI"/>
    <dbReference type="PhylomeDB" id="Q88RX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3122-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01811">
        <property type="entry name" value="YidC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023060">
        <property type="entry name" value="YidC/YidC1/YidC2_Firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000020383" description="Membrane protein insertase YidC 2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="277" mass="31697" checksum="B57670F0C8312B85" modified="2003-06-01" version="1" precursor="true">MKKYRKILAMLAVLAIVLVLSGCSNTPITDKSTGFWDGLIILNFSRAIIWLSNLFGHSYGLGIIVFTLIIRIIILPLMIFQTRNMVAMQEVQPQMKALQKKYSSRDMETQQKLQAEMKKLYAKHGVHPMASMLPLLVQLPILIALYQAIWRTQALKTGSFLWLQLGSKDPYYVLPILAAIFTFASSWLAMKSQPEQNGMTTSMTYLMPVIILITAINVPSALSLYWVISNAFQVGQTLLLQNPFKINREREAKKQAERDRKRTLEKARKRAIRNHKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SV0</accession>
    <accession>F9UTG9</accession>
    <name>KUP2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable potassium transport system protein kup 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kup2</name>
        <name type="ordered locus">lp_3279</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890801.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SV0"/>
    <dbReference type="EnsemblBacteria" id="CCC80287">
        <property type="protein sequence ID" value="CCC80287"/>
        <property type="gene ID" value="lp_3279"/>
    </dbReference>
    <dbReference type="GeneID" id="57026550"/>
    <dbReference type="GeneID" id="66450815"/>
    <dbReference type="KEGG" id="lpl:lp_3279"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2736"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_1_9"/>
    <dbReference type="OMA" id="TILLYEW"/>
    <dbReference type="PhylomeDB" id="Q88SV0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2775-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000209028" description="Probable potassium transport system protein kup 2">
        <location>
            <begin position="1"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="680" mass="75704" checksum="7C5066E962370EA8" modified="2003-06-01" version="1">MRKQRIQERSLIGMLITLGVVYGDIGTSPLYVMNALINDAGQLKNATPDYVIGSVSLIFWTLMLITTVKYVLIALRADNHHEGGIFALYALVRHRAKWLIFVALIGGAALLADGTLTPAVTVTSAVEGLKGLPKLGAFSQYPWLVPLTVTVILLVLFMIQGFGTAVVGRSFGPMMLLWFTVIGIFGLINISQAPVILKAFSPVYAVQVLFNPANKMGIFILGSVFLATTGAEALYSDMGHVGKANIDATWPFVYTTLILNYLGQGAWMLTHYQDAAWRNATNVNPFYAMVPAGGQIAMIILATAAAIIASQALITGSYTLVDEAVGLKFLPRMIIKHPSNVRSQIYIGAINWLLCLVTLGIVWLFQTSAHMEAAYGLAITLTMLMTTILLSQWIHMKGHRALALALLFGFGALETVFLTASLTKFIHGGYLTLGLTLVIFLIMVVWFFGNRRRLRYNQANEQISLLDYRNQLIQLSHDDHLPVFATNLVYLAKVDHQHRVKRSILYSILDKRPKRAKVYWFITINETNRPYDCSYSIDMLGTRNIVEVQLNLGFRKSQHINLYLRQIVTNLIADHSIDPQYSRYGITQPRQVGDFKFVVQNQQIMDLASNPTMGQFDRLLIGGRVLLQNITPSPAIWYGLAFSDVLEETIPLFTKPATDATLTNLTVHHARTPQRNSRQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UT5</accession>
    <accession>F9UQS2</accession>
    <name>GLYA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">lp_2375</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101725.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UT5"/>
    <dbReference type="SMR" id="Q88UT5"/>
    <dbReference type="STRING" id="220668.lp_2375"/>
    <dbReference type="EnsemblBacteria" id="CCC79561">
        <property type="protein sequence ID" value="CCC79561"/>
        <property type="gene ID" value="lp_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2375"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2007"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_9"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="PhylomeDB" id="Q88UT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2046-MON"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000113592" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="412" mass="44402" checksum="732C8B5BAD4BA233" modified="2003-06-01" version="1">MNYQEQDPEVWAAISKEQARQQHNIELIASENIVSKGVRAAQGSVLTNKYSEGYPGHRFYGGNEYIDQVETLAIERAKKLFGAEYANVQPHSGSQANAAAYMALIQPGDRVMGMSLDAGGHLTHGSSVNFSGKLYDFQGYGLDPETAELNYDAILAQAQDFQPKLIVAGASAYSRLIDFKKFREIADQVGALLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGMILAKEKYGKKINSAVFPGNQGGPLDHVIAGKAIALGEDLQPEFKVYAQHIIDNAKAMAKVFNDSDLVRVISGGTDNHLMTIDVTKSGLNGRQVQDLLDTVYITVNKEAIPNETLGAFKTSGIRLGTPAITTRGFDEADATKVAELILQALQAPTDQANLDDVKQQAMALTAKHPIDVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU5</accession>
    <accession>F9UQR1</accession>
    <name>MURA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase 1</fullName>
            <shortName evidence="1">EPT 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA1</name>
        <name type="ordered locus">lp_2361</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890064.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU5"/>
    <dbReference type="SMR" id="Q88UU5"/>
    <dbReference type="STRING" id="220668.lp_2361"/>
    <dbReference type="EnsemblBacteria" id="CCC79550">
        <property type="protein sequence ID" value="CCC79550"/>
        <property type="gene ID" value="lp_2361"/>
    </dbReference>
    <dbReference type="GeneID" id="57025894"/>
    <dbReference type="KEGG" id="lpl:lp_2361"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1995"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_9"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="PhylomeDB" id="Q88UU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2034-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000178881" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="438" mass="47147" checksum="E48B4C5686B3A8AA" modified="2003-06-01" version="1">MEEIVVHGGQRLTGNVHIEGAKNAVLPILAASLLASSGQTHLSNVPVLSDVFTMNNVLKFLNTKIDFDEINKTIDIDASRQLSSEAPFQYVSKMRASIVVMGPLLARLGHAKVAMPGGCAIGSRPIDLHLKGLNALGAEIERHDGYVEATANQLHGAAIYLDFPSVGATQNIMMAATLADGITTMENVAREPEIVDLANYLNQMGAKVTGAGTETIRIEGVKAMHGCDHSIVQDRIEAGTFMVAAAVTQGNVLVEDAIAEHNKPLISKMREMGVTVTEEPAGIRVIGPEILKPTSVKTMPHPGFPTDMQPQMTILQLCAQGTSLLTETVFENRFMHLDELRRMNADFKVEGRSVIMYGPTDFNGAQVTATDLRAAAALVIAGLVSRGYTEVTNLKYLDRGYFNFHGKLAKLGAEIKRVDVPDGTVYALNPDFANEAAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UX2</accession>
    <accession>F9UQN4</accession>
    <name>EZRA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Septation ring formation regulator EzrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ezrA</name>
        <name type="ordered locus">lp_2328</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Colocalized with FtsZ to the nascent septal site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EzrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UX2"/>
    <dbReference type="SMR" id="Q88UX2"/>
    <dbReference type="STRING" id="220668.lp_2328"/>
    <dbReference type="EnsemblBacteria" id="CCC79523">
        <property type="protein sequence ID" value="CCC79523"/>
        <property type="gene ID" value="lp_2328"/>
    </dbReference>
    <dbReference type="GeneID" id="57025860"/>
    <dbReference type="KEGG" id="lpl:lp_2328"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1968"/>
    <dbReference type="eggNOG" id="COG4477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034079_2_0_9"/>
    <dbReference type="OMA" id="FRSQNHI"/>
    <dbReference type="PhylomeDB" id="Q88UX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2007-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00728">
        <property type="entry name" value="EzrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010379">
        <property type="entry name" value="EzrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06160">
        <property type="entry name" value="EzrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172873" description="Septation ring formation regulator EzrA">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="1"/>
            <end position="2"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="22"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00728"/>
        </source>
    </evidence>
    <sequence length="573" mass="64497" checksum="1B050AC94C2A9E2C" modified="2003-06-01" version="1">MQVAIGIVVVAIVIYAAVKGFQFYIDKQVRQLTERQQALVKQSQTTDFEKIEQLGLTGGSLAKLEALQSAGQEVDNDQLPAVSEQLTAITSQARGIRFLDAQQNLKKVAATLDTIEQRQAEIRQGLQALDDADAAHRQAVASLEKKYQNIRKTLLSQNFSFGPSIDKLEDQLANLESDFDHFSELAKAGDHDAAEKVLDQLHHDTGTLEMDIDRIPPIYKDLVSGFPDQLAELASGYQQLTAQHFHFEVESIEPEIKALQQAIDDNIALLGDLKVTDAENGNHAIEKRIDHLYDVMQAEIDAKAVVDQQQEEISKFLTHAMNQNHRLQIELDRLAQSYTLNNGEVERTRELNEQLKNIEAVYQADVTAITSKQAVFSEIAAHFAEQDEQLKGIEEEQVAINKGVASLTAEESKAHETLQRFDFEIHAIKRQVENLNLPGLPKDYLDYFKVVAKEIERLDHDINKLVINMDDITKQLIVIQADMATLKEKTSDLTDAAVMAEQLLQYANRYKTNHEEVQEASVEAQRLFTETHDYARSLEVIATAVDKVDPGSYKRIEDSYYANKQADKMNDEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VG6</accession>
    <accession>F9UQ39</accession>
    <name>RNZ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Z</fullName>
            <shortName evidence="1">RNase Z</shortName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnz</name>
        <name type="ordered locus">lp_2090</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640772.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889842.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VG6"/>
    <dbReference type="SMR" id="Q88VG6"/>
    <dbReference type="STRING" id="220668.lp_2090"/>
    <dbReference type="EnsemblBacteria" id="CCC79328">
        <property type="protein sequence ID" value="CCC79328"/>
        <property type="gene ID" value="lp_2090"/>
    </dbReference>
    <dbReference type="GeneID" id="66449863"/>
    <dbReference type="KEGG" id="lpl:lp_2090"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1769"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_0_9"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="PhylomeDB" id="Q88VG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1789-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000155872" description="Ribonuclease Z">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <sequence length="311" mass="34229" checksum="8290212C14AB8F7B" modified="2003-06-01" version="1">MQLEFLGTGAGSPGKFRNVTSTALRLLDERNEVWLFDVGEGTQHQILRTTLKPRKIAKIFITHLHGDHIFGLPGLLSSRSFQGGDEPLTIYGPVGVRDFVQTALRVSGTHLSYPLKFHEITKAETVFEDATFKVSCEPLDHRIACFGYRVEEADHPGELQADRLKALNIPSGPVYGQLKAGKTVTLPDGRTINGQDYIAAPQKGRTVTILGDTRRTPHAVSLAQDADALVHESTFGKDEGKLAHNYYHSTSTQAAQVAQQAGVKQLLLTHISARYTGKLSKELQKQAQKVFSHSKVVRDFDVIDIPLPEKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VM0</accession>
    <accession>F9UPY4</accession>
    <name>DNAK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">lp_2027</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101636.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889787.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VM0"/>
    <dbReference type="SMR" id="Q88VM0"/>
    <dbReference type="STRING" id="220668.lp_2027"/>
    <dbReference type="PRIDE" id="Q88VM0"/>
    <dbReference type="EnsemblBacteria" id="CCC79273">
        <property type="protein sequence ID" value="CCC79273"/>
        <property type="gene ID" value="lp_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2027"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1712"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_9"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="PhylomeDB" id="Q88VM0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1734-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078475" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="622" mass="66730" checksum="2E96385123969521" modified="2003-06-01" version="1">MASNKIIGIDLGTTNSAVAVLEGNEPKIITTPEGGRTVPSVVAFKDGETQVGEVAKRQAITNPNTVASIKRHMGEAGYKVSIEGKDYTPQQISAMILQYIKGFAEDYLGDTVEKAVVTVPAYFNDAQRQATKDAGKIAGLNIERIINEPTAAALAYGLDKTDKDEKILVYDLGGGTFDVSILELGDGVFEVLSTNGDTHLGGDDFDQKIIDWLVDGFKADNGVDLSKDKMALQRLKDAAEKAKKDLSGVSEAQISLPFISAGASGPLHLETTLTRAKFNELTADLVEKTRIPVENALKDADLSASDLDVVILNGGSTRIPAVQEAVEKWTGKESNHSINPDEAVALGAAVQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGVPQIEVKFDIDKNGIVNVSAKDMGTNKEQKITIKSSSGLSDDEIDQMVKEAKENEEADKKRKEEVDLKNEVDQLIFTTDKTLKDLEGKVSEDEVKKAKDARDALKKAQDDNNIDEMKAKKDDLNKIVQDLSVKLYQQAQEAQGAQGGADSNAAGNANSAKGSDDNTVDGDFEDLDKDKDKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VM1</accession>
    <accession>F9UPY3</accession>
    <name>DNAJ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name type="ordered locus">lp_2026</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889786.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VM1"/>
    <dbReference type="SMR" id="Q88VM1"/>
    <dbReference type="STRING" id="220668.lp_2026"/>
    <dbReference type="EnsemblBacteria" id="CCC79272">
        <property type="protein sequence ID" value="CCC79272"/>
        <property type="gene ID" value="lp_2026"/>
    </dbReference>
    <dbReference type="GeneID" id="57025578"/>
    <dbReference type="GeneID" id="66449805"/>
    <dbReference type="KEGG" id="lpl:lp_2026"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1711"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_9"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="PhylomeDB" id="Q88VM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1733-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000070804" description="Chaperone protein DnaJ">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <sequence length="380" mass="40550" checksum="5088A5162DD3313B" modified="2003-06-01" version="1">MAEQDLYKVLGVEKDASQDEIKKAYRKLSKKYHPDLNHEPGAEEKFKAVNEAYETLGDAQKRAQYDQFGSTGGQQGFGGAGGFGGQDFGGFGGGGGFEDIFSSFFGGGAGGSRRSNPTAPQQGRDLQYEMTLKFEDAIFGKKTTITYNREEQCETCGGSGAKPGTSPVTCSKCHGAGYIQVQTNTPLGRMMSQQVCDVCHGTGKEIKDKCATCGGSGHTEQSHSIKVTVPAGVEEGQQMRLQNQGEAGTNGGPYGDLFIIFRVEPSKDFERDGATIYFKLPIDFVQAALGDEVQVKTVHGDVKLKIPAGTQTGTTFRLRGKGAPRLRGNGNGDERVTVNIETPTHLNKGQKEALKTFAKASGKSVAGNGKSSLFDKLRGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VS3</accession>
    <accession>F9UPS9</accession>
    <name>SYGB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyS</name>
        <name type="ordered locus">lp_1964</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101608.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889732.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VS3"/>
    <dbReference type="SMR" id="Q88VS3"/>
    <dbReference type="STRING" id="220668.lp_1964"/>
    <dbReference type="EnsemblBacteria" id="CCC79218">
        <property type="protein sequence ID" value="CCC79218"/>
        <property type="gene ID" value="lp_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1964"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1658"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_9"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="PhylomeDB" id="Q88VS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1682-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072909" description="Glycine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <sequence length="694" mass="78532" checksum="37752F3F0DA95B1E" modified="2003-06-01" version="1">MAKTYLLEIGLEEMPAHVVTPSVLQLKERMIKFLKDARLDFEDVKTFSTPRRLTVQVLGLADKQADVKKEVRGPAKKIAQDADGNWTKAAIGFSKGQGASTDDIVFKDVKGTPYVFVQTFTAGKTAAEVLTGGIKDVITKMNFPTMMKWSTYSFKYIRPIRWIVSLLDDEVVPVQILDVAAGRVSRGHRFLGHDVEIATAADYEADLASVQVVADAAKRKATIREQIAALANERDWQIKVNEDLLEEVNNLVEYPTAFAGDFDTKYLTIPDEVLITSMRDHQRFFYVTDAEDNLLPHFVSVRNGNTDHLENVALGNQKVLTARLEDAAFFYHEDQQHSIQEYVERLKKVSFHDKIGTMYEKMQRVMIISDFLADRFGLTETEKNQLHRAAQIYKFDLVTGMVGEFPELQGVMGDKYAVLKGEDPAVGQAIREHYMPISADGDLPKSKVGAVLAIADKVDSITSFFAVGLTPSGSNDPFALRRQAFGIVRIVREQGWDFPIRQLEADIQKELVAHDATYNLDFEKQTAPVADFLTDRVKQWFNNRKIRYDIVDTVIKGSRQDIREMFKAADVLNAHQDDPQFKDTIEAFTRLLRITAKAKLAADDLTVDPSLFENEAEQHLYDAVLELQKQFTPAMSMEDRFKALAALRPLIVDYFEQTMVMSKDEKVRDNHLKQLLTIAQMINVMGDLNQLIVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WT1</accession>
    <accession>F9UNR9</accession>
    <name>TMCAL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name type="ordered locus">lp_1534</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889372.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WT1"/>
    <dbReference type="SMR" id="Q88WT1"/>
    <dbReference type="STRING" id="220668.lp_1534"/>
    <dbReference type="EnsemblBacteria" id="CCC78858">
        <property type="protein sequence ID" value="CCC78858"/>
        <property type="gene ID" value="lp_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1534"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1292"/>
    <dbReference type="eggNOG" id="COG1323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038915_0_2_9"/>
    <dbReference type="OMA" id="WARTKMA"/>
    <dbReference type="PhylomeDB" id="Q88WT1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1319-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000147170" description="tRNA(Met) cytidine acetate ligase">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <sequence length="383" mass="43061" checksum="900DA7BCF9FC733E" modified="2003-06-01" version="1">MQAVGLITEYNPLHNGHRYHLRQAQQLTNADCVIVVMSGDWLQRGEPAILDKWTRAKLALENGADLVIELPVFFATQPAHLFARGGIELLSALDCTSVVFGAEHPELDFQRLATAIAARQGSFTHYNATFATQFNAALQAATGVTLTAANDMLSFCYYAANQTLAHPMQLLPIKRRQADHATTTIAADSRYASGTAVRQAALAQDWAALKPVVPADTFTALTTQRLQRWSDFWPFLQYQLLTVDVARSGQYDQMAEGLEYRMQAMAQHATTFDDFIHQVKSKRYTYTRLQRVATAALLQLTQAEVQKAQAHNYLRVLGFTPKGQAYLHQVKKQLPLPLYTKINQDLRQHALNLDYRAGRVYQLINGQSQDLYRQPWRLPVTIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X16</accession>
    <accession>F9UNI2</accession>
    <name>RISB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="1">DMRL synthase</shortName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lumazine synthase</shortName>
            <ecNumber evidence="1">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribH</name>
        <name type="ordered locus">lp_1438</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101407.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889285.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X16"/>
    <dbReference type="SMR" id="Q88X16"/>
    <dbReference type="STRING" id="220668.lp_1438"/>
    <dbReference type="EnsemblBacteria" id="CCC78771">
        <property type="protein sequence ID" value="CCC78771"/>
        <property type="gene ID" value="lp_1438"/>
    </dbReference>
    <dbReference type="GeneID" id="57025072"/>
    <dbReference type="KEGG" id="lpl:lp_1438"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1204"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_1_9"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="PhylomeDB" id="Q88X16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1232-MON"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000134766" description="6,7-dimethyl-8-ribityllumazine synthase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <sequence length="159" mass="16748" checksum="C28956FE04733541" modified="2003-06-01" version="1">MTTFNGKINGNGLKIGIAVARFNAFVTQQLLTGAQESLVQHGVNETDIDVAWVPGAFEIPLTVQKMITTKRYDGVIALGAVIRGATAHFDYVCSGVTTGIATVSLATDTPIMFGVLTTDTIEQAMDRAGFKSGNKGADCAVSLLETLDVQRAILKADLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW0</accession>
    <accession>F9UMN1</accession>
    <name>RPOA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">lp_1062</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888984.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW0"/>
    <dbReference type="SMR" id="Q88XW0"/>
    <dbReference type="STRING" id="220668.lp_1062"/>
    <dbReference type="EnsemblBacteria" id="CCC78470">
        <property type="protein sequence ID" value="CCC78470"/>
        <property type="gene ID" value="lp_1062"/>
    </dbReference>
    <dbReference type="GeneID" id="57024717"/>
    <dbReference type="GeneID" id="66448973"/>
    <dbReference type="KEGG" id="lpl:lp_1062"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.897"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_9"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="PhylomeDB" id="Q88XW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-913-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175321" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="245"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="314" mass="34842" checksum="573B3160D42DE7DF" modified="2003-06-01" version="1">MIEFEKPNIHKIDENDNYGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVTSIQIDGVLHEFSTIEGVTEDVTAIILNVKKIALKLESDETKTLEIDVKGPANVTAGDIIGDADVEVLNPDLPICTVADGAHFHMRMTANTGRGYVSAEDNKHREDDMPIGVLAVDSLYSPIERVNYQVENTRVGQRDDFDKLTLDVWTNGSITPSEAISLSAKILTDHLSIFVNLTDEAKNTDVMVEKEETHKEKMLEMTIEELDLSVRSYNCLKRAGINTVQELTNKTEADMMKVRNLGRKSLEEVKAKLADLGLSLRKED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW9</accession>
    <accession>F9UMM2</accession>
    <name>RS5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">lp_1053</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW9"/>
    <dbReference type="SMR" id="Q88XW9"/>
    <dbReference type="STRING" id="220668.lp_1053"/>
    <dbReference type="EnsemblBacteria" id="CCC78461">
        <property type="protein sequence ID" value="CCC78461"/>
        <property type="gene ID" value="lp_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="49393334"/>
    <dbReference type="GeneID" id="57024708"/>
    <dbReference type="GeneID" id="66448964"/>
    <dbReference type="KEGG" id="lpl:lp_1053"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.888"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_9"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="PhylomeDB" id="Q88XW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-904-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131531" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="166" mass="17261" checksum="D45DA3B5678E35EF" modified="2003-06-01" version="1">MTFIDPSKLDLDDNVVAINRITKVVKGGRRLRFAALVIVGDHKGHVGFGTGKAQEVPEAIRKASEAAKKNLITVPMVGTTIPHEALGVYGGGRIMLKPAVEGSGVAAGGAVRAVMELAGVDDVTSKRLGSNTPVNVVRATFEGLKSLKTAEQVAALRGVSAEHLAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY3</accession>
    <accession>F9UMK8</accession>
    <name>RL2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">lp_1036</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641255.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888961.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY3"/>
    <dbReference type="SMR" id="Q88XY3"/>
    <dbReference type="STRING" id="220668.lp_1036"/>
    <dbReference type="EnsemblBacteria" id="CCC78447">
        <property type="protein sequence ID" value="CCC78447"/>
        <property type="gene ID" value="lp_1036"/>
    </dbReference>
    <dbReference type="GeneID" id="57024694"/>
    <dbReference type="KEGG" id="lpl:lp_1036"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.874"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_9"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="PhylomeDB" id="Q88XY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-890-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129572" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="279" mass="30192" checksum="B61BBB6FC8CA6AB8" modified="2003-06-01" version="1">MGIKKYKPTTNGRRNMTASDFSEITKTKPEKSLLDSQSHTAGRNSYGHITVRHRGGGHKQQYRLVDFKRIKDEVPATVKAIEYDPNRTANIALLVYADGVKSYILAPKGLEVGMQVQSGAEADIKVGNALPLTNIPVGTVIHNIELKPGKGGQLARSAGTSAQLLGKEGKYAIVRLSSGEVRLVLLTSRATIGTVGNEQHELINSGKAGRTRWQGKRPTVRGSVMNPNDHPHGGGEGKAPIGHPSPMSPWGKKTLGKKTRNKKARSNKLIVRGRRPGKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY4</accession>
    <accession>F9UMK7</accession>
    <name>RL23_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">lp_1035</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888960.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY4"/>
    <dbReference type="SMR" id="Q88XY4"/>
    <dbReference type="STRING" id="220668.lp_1035"/>
    <dbReference type="EnsemblBacteria" id="CCC78446">
        <property type="protein sequence ID" value="CCC78446"/>
        <property type="gene ID" value="lp_1035"/>
    </dbReference>
    <dbReference type="GeneID" id="57024693"/>
    <dbReference type="KEGG" id="lpl:lp_1035"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.873"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_9"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="PhylomeDB" id="Q88XY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-889-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000068094" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="97" mass="11152" checksum="0AEA1125A686FF3F" modified="2003-06-01" version="1">MEARDVILRPVVTESSMADLDDKRYTFDVNVQATKTQVKKAIEEIFDVKVVKVNVMNVKGKLKRQGRYAGYTKKRRKAIVTLSSDSNEIKLFNDDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YH7</accession>
    <name>Q88YH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Central glycolytic genes regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cggR</name>
        <name evidence="3" type="ordered locus">lp_0788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641043.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0788"/>
    <dbReference type="EnsemblBacteria" id="CCC78248">
        <property type="protein sequence ID" value="CCC78248"/>
        <property type="gene ID" value="lp_0788"/>
    </dbReference>
    <dbReference type="GeneID" id="57024490"/>
    <dbReference type="GeneID" id="66448752"/>
    <dbReference type="KEGG" id="lpl:lp_0788"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.665"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054506_2_0_9"/>
    <dbReference type="OMA" id="SVAYYQD"/>
    <dbReference type="PhylomeDB" id="Q88YH7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-684-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="94"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="343" mass="38076" checksum="48E982F4A68CACE0" modified="2003-06-01" version="1">MHSDIQWIEAIAPDMVDMLSRRYLVLRTINWMAPVGRRLLAQTLGVSERTLRTETDTLRKLDLIMTNKSGMQVTQQGQDVLVGLSHFMDELMGIRQKERQLAQYFNIKRCIIVSGDSDRQLKVIGTMGEEVNQLLQQLLPEGRNIIAVMGGHTMEHVASHLTNKLGDKRDLLFVPARGGVGESVAIQANTIASQMAQHTGGKFRSLFVPEQVSERTYEPLLKEPSIQEVLAIIGQANVVVHSIGEAISMAHRRNMSEDQIKVLRSREAIGEAFGYFFDKKGNVVYRIPRIGLQIGELAHREIILAIAGGASKATAIAAYMKNIAPKQTCLITDEGAANLILKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YM5</accession>
    <accession>F9ULV9</accession>
    <name>CH60_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">lp_0728</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888712.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YM5"/>
    <dbReference type="SMR" id="Q88YM5"/>
    <dbReference type="STRING" id="220668.lp_0728"/>
    <dbReference type="EnsemblBacteria" id="CCC78198">
        <property type="protein sequence ID" value="CCC78198"/>
        <property type="gene ID" value="lp_0728"/>
    </dbReference>
    <dbReference type="GeneID" id="57024433"/>
    <dbReference type="GeneID" id="66448701"/>
    <dbReference type="KEGG" id="lpl:lp_0728"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.613"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_9"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="PhylomeDB" id="Q88YM5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-633-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000063402" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="476"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="541" mass="57437" checksum="114336074F965255" modified="2003-06-01" version="1">MAKELKFSEDARSAMLKGVDQLADTVKSTLGPKGRNVVLEQSYGSPTITNDGVTIAKAIELDDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQSIVNEGMKNVTAGANPVGIRRGIEEATKTAVDSLHAMAHEVKTQEDIAQIASVSSASEETGKLIAEAMEKVGHDGVITIEESRGVDTSLDVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQSIVEQGKPLLIIADDISGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLQDIAILTGGTVITDDLGLELKDTTIDQLGQANKVTVTKDNTTIVEGAGSKDAISERVEFIRNQIGETTSDFDKEKLQERLAKLAGGVAVVRVGAATETELKERKYRIEDALNATRAAVEEGFVAGGGTALINVIKDVAALKETGDVQTGINIVKRALEEPVRQIAENAGLEGSVIVEKMKEQKPGVGFNAATDEWVDMIKAGIVDPTKVTRSALQNAASVSALLLTTEAVVAEKPEENAPAAPAAPNPGMGGMM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z31</accession>
    <accession>F9UL20</accession>
    <name>FTSH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsH</name>
        <name type="ordered locus">lp_0547</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="1688" last="1694">
            <title>The Lactobacillus plantarum ftsH gene is a novel member of the CtsR stress response regulon.</title>
            <authorList>
                <person name="Fiocco D."/>
                <person name="Collins M."/>
                <person name="Muscariello L."/>
                <person name="Hols P."/>
                <person name="Kleerebezem M."/>
                <person name="Msadek T."/>
                <person name="Spano G."/>
            </authorList>
            <dbReference type="PubMed" id="19074391"/>
            <dbReference type="DOI" id="10.1128/JB.01551-08"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expressed at a low constitutive level, expression is increased after exposure to 42 degrees Celsius. Transcription is partially repressed by CtsR.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Cells grow more slowly under optimal conditions, and much mre slowly at 42 degrees Celsius.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="AY644764">
        <property type="protein sequence ID" value="AAU05734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888549.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z31"/>
    <dbReference type="SMR" id="Q88Z31"/>
    <dbReference type="STRING" id="220668.lp_0547"/>
    <dbReference type="MEROPS" id="M41.009"/>
    <dbReference type="EnsemblBacteria" id="CCC78035">
        <property type="protein sequence ID" value="CCC78035"/>
        <property type="gene ID" value="lp_0547"/>
    </dbReference>
    <dbReference type="GeneID" id="57024321"/>
    <dbReference type="GeneID" id="66448597"/>
    <dbReference type="KEGG" id="lpl:lp_0547"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.453"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_9"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="PhylomeDB" id="Q88Z31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-456-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000400346" description="ATP-dependent zinc metalloprotease FtsH">
        <location>
            <begin position="1"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="153"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19074391"/>
        </source>
    </evidence>
    <sequence length="745" mass="80803" checksum="0690A8E2D72D74F6" modified="2003-06-01" version="1">MNNRRNGLFRNSLFYILMFLSLMGIIYFFFGGNSGSQTQNIRYSEFVKQLDKNNVKNVSIQPSGGVYKVTGSYRKARTTSSANALGIKSASTKTTSFSTTMLENNSTVDQVSKLAAKHDVKVTAKAEESSGIWVTLLMYIAPVILMLFLFYMMMGQAGQGGGNNRVMNFGKTKAKPADSKQNKVRFSDVAGEEEEKQELVEVVEFLKDPRKFVSLGARIPSGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPSIIFIDEIDAVGRQRGNGMGGGHDEREQTLNQLLVEMDGFTGNEGVIVMAATNRSDVLDPALLRPGRFDRKILVGRPDVKGREAILKVHAKNKPLAADVDLKEIAKQTPGFVGADLENLLNEAALLAARRNKKQVDAADLDEAEDRVIAGPAKHDRVVNKHERETVAYHEAGHTIVGLVLNDARVVHKVTIVPRGRAGGYAIMLPREDQMLMSKRDAKEQMAGLMGGRAAEEIIFGAQSSGASNDFEQATQIARAMVTQYGMSEKLGPVELENANQQAAYQQGMGASAFSQHTAQLIDDEVRRLSQEAHQTATDIIESHREQHKLIAEALLKYETLDEKQILSLFKTGKMPEKDSNEFPSEKAATFEESKRELERREAEKHAQNQSADDKQADSADTTTNVSVAEPSFPSESDASSEVSADSSVNSTANSATESATDSDVATSATGLPNAESATPSSQDDTNSQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZJ6</accession>
    <accession>F9UTS2</accession>
    <name>POTA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="1">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">potA</name>
        <name type="ordered locus">lp_0318</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + polyamine-[polyamine-binding protein]Side 1 = ADP + phosphate + polyamineSide 2 + [polyamine-binding protein]Side 1.</text>
            <dbReference type="EC" id="7.6.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888356.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZJ6"/>
    <dbReference type="SMR" id="Q88ZJ6"/>
    <dbReference type="STRING" id="220668.lp_0318"/>
    <dbReference type="EnsemblBacteria" id="CCC77842">
        <property type="protein sequence ID" value="CCC77842"/>
        <property type="gene ID" value="lp_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0318"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.270"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_9"/>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="PhylomeDB" id="Q88ZJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-264-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51305">
        <property type="entry name" value="POTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000286233" description="Spermidine/putrescine import ATP-binding protein PotA">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01726"/>
        </source>
    </evidence>
    <sequence length="365" mass="40686" checksum="50AAC919CC3D4019" modified="2003-06-01" version="1">MAVNTQPIIRLTNVTKSYGEHQVLKNINLDLEAGKFYTLLGPSGCGKTTILRTIAGFTDATSGQVYFDGQVINTLPANQRQVNTVFQDYALFPHMNVAENVAFGLKLHKVPKDEIETRVQKALAMVQLADLGEREISEISGGQQQRVAIARALVMQPKVLLLDEPLSALDAKLRKDMQYELRDLQQRLGITFLFVTHDQEEALAMSDEIFVMNAGEILQGGSPVDIYDEPINHFVANFIGESNIIPGKMLKDFEVEFVGKQFECADAGMQPNEAVEVVLRPEDLDIVAANQGKLVVTVDSQLFRGNYFEIVAYDTDHNEWLVHSTNPAAEGEPIGLTFDPQDIHVMRLNESEAAFDARLEQYEDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q890J5</accession>
    <accession>F9US46</accession>
    <name>PROB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">lp_0016</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643611.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890J5"/>
    <dbReference type="SMR" id="Q890J5"/>
    <dbReference type="STRING" id="220668.lp_0016"/>
    <dbReference type="EnsemblBacteria" id="CCC77593">
        <property type="protein sequence ID" value="CCC77593"/>
        <property type="gene ID" value="lp_0016"/>
    </dbReference>
    <dbReference type="GeneID" id="57026878"/>
    <dbReference type="KEGG" id="lpl:lp_0016"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.14"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_0_2_9"/>
    <dbReference type="PhylomeDB" id="Q890J5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-14-MON"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109683" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="265" mass="28796" checksum="160B92EA661C9A29" modified="2011-11-16" version="2">MKVIRKLKAKRVVIKVGTSTLVYPDGSINLRAIDQLAFVISAMRHRGREVVLVSSGAIGVGLNYMGLKQRPKAIPEQQAIAAIGQTELISIYKERFAIYEQKIGQLLLTRDIFVYPKSHHNVLNTFEALLKQNVVPIVNENDTVAVDELDHETKFGDNDQLSAIVATNIGADLLIMLSDIDGFYDGNPNADARAQLLGHIEKVDQHTYKLAGGSGSRFGTGGMVTKLKAAERMIDANGQMILANGADPTIIFQILAGEPVGTLFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q890K2</accession>
    <accession>F9US39</accession>
    <name>RS6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsF</name>
        <name type="ordered locus">lp_0009</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890K2"/>
    <dbReference type="SMR" id="Q890K2"/>
    <dbReference type="STRING" id="220668.lp_0009"/>
    <dbReference type="PRIDE" id="Q890K2"/>
    <dbReference type="EnsemblBacteria" id="CCC77586">
        <property type="protein sequence ID" value="CCC77586"/>
        <property type="gene ID" value="lp_0009"/>
    </dbReference>
    <dbReference type="GeneID" id="49392389"/>
    <dbReference type="GeneID" id="57026870"/>
    <dbReference type="GeneID" id="66448164"/>
    <dbReference type="KEGG" id="lpl:lp_0009"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.7"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_3_9"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="PhylomeDB" id="Q890K2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-7-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176781" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <sequence length="99" mass="11428" checksum="B77432E76CF3DED8" modified="2003-06-20" version="1">MSESKKYEITYIVRPDIDDAAKTALVDRFDKILTDNGAQVIDSKDWSKRRFAYEIGGFNEGTYHIVNLTATDDAALNEFDRLSKINDDILRHMIVKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX6</accession>
    <name>F9UKX6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyribonucleoside regulator, putative inducer deoxyribose 5-P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoR</name>
        <name evidence="4" type="ordered locus">lp_0495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0495"/>
    <dbReference type="EnsemblBacteria" id="CCC77991">
        <property type="protein sequence ID" value="CCC77991"/>
        <property type="gene ID" value="lp_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0495"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.408"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054506_1_1_9"/>
    <dbReference type="OMA" id="WINGLVT"/>
    <dbReference type="PhylomeDB" id="F9UKX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-412-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="316" mass="34415" checksum="16170F7B843CF27C" modified="2011-10-19" version="1">MEKAINQDKVKLALKVCHLYYEDGLSQSDIGKQLQISRPTISRLLSYAKDTGLVKIEIADPLKDLGTLAQQLEHKYHLKKVLISFDASNDSQLINEKLGELTADYLQTIVQDHDSIGISWGKTIKAVADHLHISTRNDVRIVQLKGSVAASDMNNFANDIVTKFSAAYHTNAVTLPLPVIFDDPVTKKIVLDDRFISQIIRAGEATNIALFTSGTVRSDAMLFNLGYLNAAEIKRLQSSSVGDIVSRFITKDGTIADSAINARTVGIQLEALKHKKYAILVAGSSRKVPSIHGALMGGYANVLITDSQSATALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL28</accession>
    <name>F9UL28_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </dbReference>
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    <dbReference type="OMA" id="MIIMPAN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-473-MON"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="12101" checksum="B9919198415781BD" modified="2011-10-19" version="1">MSLINKIDHAKVLDLTEQIPLDDDQVNSRTLVQRDDLSMTLFSVATDQEIGGHSAQGDAMVNILSGEAEITIEGTIYHLTAGQSIVIPKDARHALYAVQGFQMLLVVVKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL48</accession>
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        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase NpsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">npsA</name>
        <name evidence="7" type="ordered locus">lp_0578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888577.1">
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    </dbReference>
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        <property type="gene ID" value="lp_0578"/>
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    <dbReference type="PhylomeDB" id="F9UL48"/>
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    </dbReference>
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        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Condensatn"/>
    </dbReference>
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        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
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            <end position="4881"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="1500"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="5289" mass="602599" checksum="50231ECE7FCEB982" modified="2011-10-19" version="1">[encoded data, 5289 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="10" type="primary">pts10A</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640913.1">
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004888585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="66448633"/>
    <dbReference type="KEGG" id="lpl:lp_0586"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.490"/>
    <dbReference type="eggNOG" id="COG2893">
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    <dbReference type="HOGENOM" id="CLU_123235_1_1_9"/>
    <dbReference type="OMA" id="MLIEAVF"/>
    <dbReference type="PhylomeDB" id="F9UL56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-502-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013789">
        <property type="entry name" value="PTS_EIIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00824">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15297" checksum="3BFCE2563ED63CCD" modified="2011-10-19" version="1">MLAFVVVSHGSFAQGVVDSSYMIFGKQDKVQTVTFQLDEEPNELADKLAAAVARFDADDQVLFLVDLWGGSPFNAASRIVAEHTERMGLITGLNLPMLIEAYTVRDKPIDEVIAHLEETGKIGIKHLKLLQDDGEDEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL59</accession>
    <name>F9UL59_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase, biotin carboxyl carrier protein</fullName>
            <ecNumber evidence="2">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">accB1</name>
        <name evidence="2" type="ordered locus">lp_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888588.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0589"/>
    <dbReference type="EnsemblBacteria" id="CCC78074">
        <property type="protein sequence ID" value="CCC78074"/>
        <property type="gene ID" value="lp_0589"/>
    </dbReference>
    <dbReference type="GeneID" id="57024369"/>
    <dbReference type="GeneID" id="66448636"/>
    <dbReference type="KEGG" id="lpl:lp_0589"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.493"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_3_9"/>
    <dbReference type="OMA" id="EVEWHDP"/>
    <dbReference type="PhylomeDB" id="F9UL59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-505-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="133" mass="14395" checksum="A25ADEFD6F7EE1C2" modified="2011-12-14" version="1">MELKDLDRLVEKYARQGYQQIRVKAGDLEIEVTKPALASETVTPVAATPASTVAETEDEVVTLPSPMVGVVHLAPDLKVGQSLTAGQELGQIESMKLFNPLVSPTDGTLTAVLVADDATVEYEQPLFTMRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL65</accession>
    <name>F9UL65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease, drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888594.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0595"/>
    <dbReference type="EnsemblBacteria" id="CCC78080">
        <property type="protein sequence ID" value="CCC78080"/>
        <property type="gene ID" value="lp_0595"/>
    </dbReference>
    <dbReference type="GeneID" id="57024375"/>
    <dbReference type="KEGG" id="lpl:lp_0595"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.499"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_13_0_9"/>
    <dbReference type="OMA" id="MTLYQLA"/>
    <dbReference type="PhylomeDB" id="F9UL65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-511-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="147"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="36920" checksum="1D308B15A2E62E05" modified="2011-10-19" version="1">MKKAYLYIAISTLMFSSMEIALKMAGSAFNPIQLNLIRFFIGAIVLLPFALRALKQTGRKLVSADWRLFALTGLVCVIVSMSLYQLAITVDQASTVAVLFSCNPVFALLFSYLILRERLGRANLISVVISVIGLLIIVNPAHLTNGLGLLLAIGSAVTFGLYSIISRYGSVKRGLNGLTMTCFTFFAGAFELLVLAWITKIPAVANGLTAIGLRQFAAIPVLVNVNLNYFWLLFFIGVCVTGGGFAFYFLAMEQTDVSTASLVFFIKPGLAPILAALILHEQILWTTVVGIVVILIGSVVTFVGNRFRERDTMGAIEQPTAAATDDEHVIKAAHAVSNQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA1</accession>
    <name>F9ULA1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888630.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0638"/>
    <dbReference type="EnsemblBacteria" id="CCC78116">
        <property type="protein sequence ID" value="CCC78116"/>
        <property type="gene ID" value="lp_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0638"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.532"/>
    <dbReference type="HOGENOM" id="CLU_2382524_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-549-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="94" mass="10718" checksum="2A21F47193F7125D" modified="2011-10-19" version="1">MMISMQNDAEFIDAVAVAVADRIMPQLEVLVKEYYTPDQGLNQQQAASMLGCSVDTLKDFYYYQPGFPHFKKGTKDSFSQKALEKWMADNQIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB9</accession>
    <name>F9ULB9_LACPL</name>
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        <submittedName>
            <fullName evidence="8">Sodium-coupled N-acetylneuraminate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891040.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3563"/>
    <dbReference type="EnsemblBacteria" id="CCC80526">
        <property type="protein sequence ID" value="CCC80526"/>
        <property type="gene ID" value="lp_3563"/>
    </dbReference>
    <dbReference type="GeneID" id="57026762"/>
    <dbReference type="GeneID" id="66451002"/>
    <dbReference type="KEGG" id="lpl:lp_3563"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2973"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_4_9"/>
    <dbReference type="OMA" id="YVFIHFI"/>
    <dbReference type="PhylomeDB" id="F9ULB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3014-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="98"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <end position="205"/>
        </location>
    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="502" mass="54182" checksum="95527734FC8EEBC1" modified="2011-10-19" version="1">MSKVGFGVLNWVVLGAYLLAMLGVGAYFTRKASKNTDSFFKAEGHIPAWAAGFSIYATTLSAITFMSTPEQAFLSDWAYAIGSFSILIIIPILVKFYIPFFRKLKVTTAYEYLEERFSPVMRAISSLLFVLYHISRVAIVIYLPIIAITSVSNINPILIACVVGGLCILYTFLGGIEGVIWSDVIQGFLLLGSALLICVLGIFYIKGGFGTVVNDVVTNHKFISGNDFNIGDLSKFVPLILAGQIFNSLYQYTGSQDVVQRYQTTATIKDTNKSMYTNGWLALITIPLFFGMGTILYSFYQHTAALPAGFNTSAVVPYFVITQMPAGVAGLVIAGIFAAAQSTIASSLNAISSCVITDFKQRFFNDKFKNSNDVTLARGIIIIAGVLGLAVAIYLLMGNASQIWNLFLSVTGIFGVPIAGIFAVGIFTKRANTVGVLTGLVLSVGLSFWVQSLNISSLLVACVAFISAFVLSYVVSLLFPGGNHDVTGLTVSTINETYVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC1</accession>
    <name>F9ULC1_LACPL</name>
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        <submittedName>
            <fullName evidence="1">N-acetylglucosamine 2-epimerase</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3566"/>
    <dbReference type="EnsemblBacteria" id="CCC80528">
        <property type="protein sequence ID" value="CCC80528"/>
        <property type="gene ID" value="lp_3566"/>
    </dbReference>
    <dbReference type="GeneID" id="57026764"/>
    <dbReference type="KEGG" id="lpl:lp_3566"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2975"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_068005_1_0_9"/>
    <dbReference type="OMA" id="EYIHCKA"/>
    <dbReference type="PhylomeDB" id="F9ULC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3016-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050121">
        <property type="term" value="F:N-acylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="243" mass="26985" checksum="CD124EAA068AE32A" modified="2011-10-19" version="1">MKIGINTAIYESQVQAGATQLECLKTLVTRFDVSAVEVRGEFFKPETRSAELLAISQLCEEQHWDLYYSVPEELFSSDGYNASLVTNLELATKYHIKSLKYSFGVQPTLQAHDLEALTQLLATTSIQVTIENQPNANGDLATFESDVAWVKSQKLTLGYTFDSGNWYWIDQQPEPAFAALKSAITVFHLKDIKDQTTVMLGQGATDWHSLLGQLSPEIPVFLEYNIAAADLSGQIDLVKQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ4</accession>
    <name>F9ULJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891115.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3646"/>
    <dbReference type="DNASU" id="1061620"/>
    <dbReference type="EnsemblBacteria" id="CCC80601">
        <property type="protein sequence ID" value="CCC80601"/>
        <property type="gene ID" value="lp_3646"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3646"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3045"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="OMA" id="GHYPSHW"/>
    <dbReference type="PhylomeDB" id="F9ULJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3088-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="178"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="275" mass="31504" checksum="E080718BF1B33567" modified="2011-10-19" version="1">MLQLSEFEPEVLYAFPFRNEHPGTYVYHQHDFLELSIMLEGYSDYNVEGQWRRVVAGQALLFNPGIHHQETQPPHTQSLQLHIGFRHIALPGQVPNHLPFKDALISLDDYRAEFMANAQRIVAESQRPTAFGHALLIQAMVIEQLCWLLRSLPENSVSNDYTELHQGNVSRDQQALVNAATYYLDVHYNEDLTLGTVAASLHVSAAYLSRTFKAIQGETPISYLTRLRMQRAKQLLMQEAITVRQVAHAVGYQDPYYFSKVFKRYFGAAPTLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL0</accession>
    <name>F9ULL0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-12" db="PDB data bank">
            <title>The crystal structure of an universal stress protein UspA family protein from Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Li H."/>
                <person name="Cobb G."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641607.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3FG9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.47 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-153"/>
    </dbReference>
    <dbReference type="PDBsum" id="3FG9"/>
    <dbReference type="SMR" id="F9ULL0"/>
    <dbReference type="STRING" id="220668.lp_3663"/>
    <dbReference type="EnsemblBacteria" id="CCC80617">
        <property type="protein sequence ID" value="CCC80617"/>
        <property type="gene ID" value="lp_3663"/>
    </dbReference>
    <dbReference type="GeneID" id="57026843"/>
    <dbReference type="GeneID" id="66448141"/>
    <dbReference type="KEGG" id="lpl:lp_3663"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3061"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="ESVHYNR"/>
    <dbReference type="PhylomeDB" id="F9ULL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3104-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3FG9"/>
        </source>
    </evidence>
    <sequence length="153" mass="17119" checksum="11431D73B39D8C6E" modified="2011-10-19" version="1">MENQKMQEPLVYRRILLTVDEDDNTSSERAFRYATTLAHDYDVPLGICSVLESEDINIFDSLTPSKIQAKRKHVEDVVAEYVQLAEQRGVNQVEPLVYEGGDVDDVILEQVIPEFKPDLLVTGADTEFPHSKIAGAIGPRLARKAPISVIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULP6</accession>
    <name>F9ULP6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888649.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0658"/>
    <dbReference type="EnsemblBacteria" id="CCC78135">
        <property type="protein sequence ID" value="CCC78135"/>
        <property type="gene ID" value="lp_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0658"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.550"/>
    <dbReference type="HOGENOM" id="CLU_1068708_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-569-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="30193" checksum="FE8ECD34529DD2D1" modified="2011-10-19" version="1">MGIVRSISFFGIVCITYLLSLFANLNSPDWDGWLGFFGSIFGSIIAILGVYWQVSVQAKKAKEDAKQQQDLLRKQLNNEKENQYRQARPFFIVSKELIDPQERNKESISCIYSTFYRSEVPCSILGLTHIVINNVSKRDMYAVKVLVSTSTDDNFKQEFQKYSSAAALKSDEFYKSCISIDKIAANEKVGLLFDHYNEIEQVWIWYITEMRESIKLYFENENGGLIYRPDEKRLENQQKDGSANYDLSDFEETNRLSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV5</accession>
    <name>F9ULV5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888708.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0723"/>
    <dbReference type="EnsemblBacteria" id="CCC78194">
        <property type="protein sequence ID" value="CCC78194"/>
        <property type="gene ID" value="lp_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0723"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.609"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="PhylomeDB" id="F9ULV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-629-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="331"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="660" mass="74177" checksum="10783CC765A085D1" modified="2011-10-19" version="1">MILLQVQQVMRRFGADVLFDNVQMDIQEHARVALVGRNGAGKSTLLKMIAGETVPDEGQISMRKGLTIGYLAQDQGLDSNNTIWEEMSSVFAELHAIEKRMHQLENQLSDPAIMNDEQAYQQTLKTYDQIQTEFQQKNGYGYQAEIRGVLHGFQFDADVYDKSVTALSGGQKTQLALAKLLLEKRDLLILDEPTNHLDVETLTWLESYLQSYSGALLIVSHDRYFLDRVVNEVYDLSHHEMVHYTGNYDQFVQEKAARIQAQWKHYEKQQAEISKLEDFVNRNIVRASTTKRAQARRKQLAKMDRLDRPDSDEKTAHFGFHAAKQSGNIVLTVKDAAVGYDGQILSEPDNLNIKKHEAIAIVGPNGIGKSTFLKSILGQIPFIKGQAVFGTNVVTGYYDQEQRNLNDKKTVLSELWDEHPTTPEKDIRTILGSFLFTGEDVDKPVHALSGGERARLLLTKLAMQNDNFLILDEPTNHLDIDSREVLEVALNDFDGTLLFVSHDRYFINQVATSVVEVSPEGTELFLGDYDYYIDKKQEQAEIAAAAASQAAEKAAEAGAADSTSATTAAPRSKGQQNYQASKQQQREKRKLERSVAALEEQMTALDEQATQIQTEMAQPEVSADVGKLQDLQKELEAINTQQEQVETEWTEQAEALEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX2</accession>
    <name>F9ULX2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hpk3</name>
        <name evidence="8" type="ordered locus">lp_0744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101149.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888725.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0744"/>
    <dbReference type="EnsemblBacteria" id="CCC78211">
        <property type="protein sequence ID" value="CCC78211"/>
        <property type="gene ID" value="lp_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0744"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.626"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_9"/>
    <dbReference type="OMA" id="ENQLLWC"/>
    <dbReference type="PhylomeDB" id="F9ULX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-646-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="243"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="467" mass="52608" checksum="848506987BEC087E" modified="2011-10-19" version="1">MHNRWQQTTRLLLMENVLLVLIVLVVLQHFSPIKWSWRLVGCLVGAWLVLAVIEGLIAWRQQSERQRTIDRMEAKLRQMSSQQFPPHILLPQSDPLYSLAQAVNQLESYQKSQTRRAELQEKELMMIMRYLPVGVMVIDHRRQVQLSNPAMSELLQVSVNTVAHIYTKDIQLYALTKLIEDTITSGKNQRATITLIPAPNTQVVEASTVYIQGNRSQFQIVLMLYDITEVYMIEQMQDDFVSNASHELKTPITAISGFTETLLSGAKDDPDTLDQFLHIIADESQRLIDLIQDVLSLSRIRAQNTTMLTLAPLAVRPLIEQELAVVQQAIERQHLTINNQVDADLMITSDSQKLSQIIKNLLTNAIKYNRPHGSVTIATMVSHQTWSLIVKDTGIGISADDQQRIFERFYRASPSRSQQLVSGTGLGLAIVQELVNAMHGTIDVVSQRGVGTTMTVTLPLVASASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM24</accession>
    <name>F9UM24_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888777.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0804"/>
    <dbReference type="EnsemblBacteria" id="CCC78263">
        <property type="protein sequence ID" value="CCC78263"/>
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0804"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.680"/>
    <dbReference type="eggNOG" id="COG4894">
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    <dbReference type="HOGENOM" id="CLU_108507_0_0_9"/>
    <dbReference type="OMA" id="DIWGTKS"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="21543" checksum="63A92E2362AE26E7" modified="2011-10-19" version="1">MRKLYFSRNSFAQGARIVRDAHNQSHYLLVGRWGRRQDALSLYAIQGELLAEIRQTTLGLLPKFDLYYNRQNVGSISKTLGFWHEMLYVRKLRWIIMGSLSAENYRVYHGTELIMTMRPVVTTNGEAFELAITDQSTEPLCICIAAILDHWQKPTNRARTPIAKKGLNVSFGESNYTLTPRNKVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM79</accession>
    <name>F9UM79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, Ser/Thr-rich</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888832.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0869"/>
    <dbReference type="EnsemblBacteria" id="CCC78318">
        <property type="protein sequence ID" value="CCC78318"/>
        <property type="gene ID" value="lp_0869"/>
    </dbReference>
    <dbReference type="GeneID" id="57024558"/>
    <dbReference type="GeneID" id="66448821"/>
    <dbReference type="KEGG" id="lpl:lp_0869"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.738"/>
    <dbReference type="eggNOG" id="ENOG5033I43">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124919_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-754-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388982" evidence="2">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="16940" checksum="A8A4EA397F25983F" modified="2011-10-19" version="1">MAYRTPPFISPFAIVSIVLALGATNVVVNKTTHTVNGAKATSSVVKSSSASSASLKKKAADDSSDENKSKDKSSSDTSNDEQNSSSSSSTDENDTDSSSANKTSSSSSSADDTSSSATNSSTTDNNSSTTDTSDDDESSAAESSSTTASSSTTTTSQSTTDTTTSDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME4</accession>
    <name>F9UME4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888897.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0948"/>
    <dbReference type="EnsemblBacteria" id="CCC78383">
        <property type="protein sequence ID" value="CCC78383"/>
        <property type="gene ID" value="lp_0948"/>
    </dbReference>
    <dbReference type="GeneID" id="57024624"/>
    <dbReference type="KEGG" id="lpl:lp_0948"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.805"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103307_0_0_9"/>
    <dbReference type="OMA" id="YAYYFDI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-819-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="18676" checksum="27EA9C6F6D681758" modified="2011-10-19" version="1">METTLVIIRGNSGSGKTTLAQALQRRVGHHTLLVSQDVVRRDMLMSHDYPGNISIGLIEQIVCYGLGRVPVVIVEGILARDRYGKMLARLSQSFPRVLTYYFEVSFATTLARHQKRHRDFGVEDMRRWWLPHDTLGVANEVLIGEQQDLTTEVQQIMTTIHDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV8</accession>
    <name>F9UMV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lys</name>
        <name evidence="5" type="ordered locus">lp_1158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMV8"/>
    <dbReference type="STRING" id="220668.lp_1158"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78547">
        <property type="protein sequence ID" value="CCC78547"/>
        <property type="gene ID" value="lp_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1158"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.978"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044973_6_3_9"/>
    <dbReference type="OMA" id="KMPTSVF"/>
    <dbReference type="PhylomeDB" id="F9UMV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-989-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="29028" checksum="67D0145534CC66A2" modified="2011-10-19" version="1">MTKRQHYRPVYAKTRWARWRYRLGWLLVLLVIIGSVWGGLAWLRWRSDAVVSGFDVRGVAVSQNDGYLDFAALQNDGLKFVYLHATQGASYTDDNFASNYERIVGTSLGVGVIHTFSFSSTAAAQADYFEKTVGDSIGNLPIAIQVQYYGDYTDQTIAVRKSRAKLKALVTTLTQDYNRSCVVWSTPAVAKQIVKPALKDTDLWLDTAKTHQQGRRVMFMHYSDRAVYRQNGTRQEFAGILFNGSVTAYNKVVAQGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA3</accession>
    <name>F9UNA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889206.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1333"/>
    <dbReference type="EnsemblBacteria" id="CCC78692">
        <property type="protein sequence ID" value="CCC78692"/>
        <property type="gene ID" value="lp_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1333"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1124"/>
    <dbReference type="HOGENOM" id="CLU_203868_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1150-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="6326" checksum="426398C57536A114" modified="2011-10-19" version="1">MSTLKIGTTVKLPKPYLEIVGTIIAYYAAKDQYLVRFGVSQQLYFKPDELIVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA6</accession>
    <name>F9UNA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional protein: ABC transporter,ATP-binding protein transcription regulator, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643163.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889209.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1336"/>
    <dbReference type="DNASU" id="1062694"/>
    <dbReference type="EnsemblBacteria" id="CCC78695">
        <property type="protein sequence ID" value="CCC78695"/>
        <property type="gene ID" value="lp_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1336"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1127"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049568_0_0_9"/>
    <dbReference type="OMA" id="IQMSHVE"/>
    <dbReference type="PhylomeDB" id="F9UNA6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1153-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012046">
        <property type="entry name" value="LytTR_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="224"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="37022" checksum="C723357CAE79D1A6" modified="2011-10-19" version="1">MQTIQLSNIFKQQAHQTILKDFTLTIPAQSNIGIQMSHVEATTLFNLLRQTTPQTSGVMTGLTPARIQAIFHDDGFYPQLTVSTYLKTFQHISTFETDLDDILQYFALKDVAHTKIKHLSFDQQQRLALLRAFILQPDLLLIESPLTNLTNAGIELYLAALAYTREHGVTVLLTSYSLEELVLTSTTIFRYRPNQGLELTDLATESSSDSAHTSEDTPRPIFKIASKVEDKTVFFSPNEIDFIESVNGVSQLNVSGEQFTSSQTMSELEQQLTTLGFFRCHRSYLVNLQQIAELISYSRNSYTLILKNKSKLPLSRGKLTDLKALINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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    <name>F9UNH6_LACPL</name>
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        <name evidence="3" type="ordered locus">lp_1430</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889279.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1430"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78765">
        <property type="protein sequence ID" value="CCC78765"/>
        <property type="gene ID" value="lp_1430"/>
    </dbReference>
    <dbReference type="GeneID" id="57025065"/>
    <dbReference type="KEGG" id="lpl:lp_1430"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1198"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="NKNYGQT"/>
    <dbReference type="PhylomeDB" id="F9UNH6"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="331" mass="36976" checksum="DFFBA5BC88AA5C41" modified="2011-10-19" version="1">MQNPRLTIIVPCYNEEAVLPKSAHILDGILTDLIQHKQVNAASKLLFVDDGSQDKTWKLIKSLEKQYSTVTGLKFSRNFGHQNALMAGMQVASPTAEIVITIDADLQDDPQVIPEMVARYRAGSDIVLGVRNDRSSDSLFKRWTADGFYRLMKRIGVQLVPNHADFRLLSQRAVQALLTYEETNLFLRGIVPRLGFPTTKLYYHRQPRFAGVSKYPLRKMVAFAFDGITSFSIAPIKVILLFGMVISGGSLMMMLYALIQGLLGTATSGWSSLMTSLWFLGGMQLIGISIVGEYVGKIFAEVKHRPRYIIETDDYTATQQPAIVNSQRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ0</accession>
    <name>F9UNJ0_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Cell surface protein, DUF916/CscA family</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">lp_1448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889293.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1448"/>
    <dbReference type="EnsemblBacteria" id="CCC78779">
        <property type="protein sequence ID" value="CCC78779"/>
        <property type="gene ID" value="lp_1448"/>
    </dbReference>
    <dbReference type="GeneID" id="57025080"/>
    <dbReference type="KEGG" id="lpl:lp_1448"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1212"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_0_1_9"/>
    <dbReference type="OMA" id="PYEENEM"/>
    <dbReference type="PhylomeDB" id="F9UNJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1240-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394268" evidence="2">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="167"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="348" mass="38487" checksum="17450415B8399B41" modified="2011-10-19" version="1">MKKLMCLFGVIGGLVFMSWTSPSVQATATNAEVQYSVNKISPGQEVDASSPFFDLKAKAGTTRKIQARVYNPTDQSITVKTQLLTTFTNDSGQIAYTQTAKRYDASLKYRFDQIATLAAGSDKVTVPAKSNRVVSATINIPKGFDTGVILGSWYFEKMGQGAKKASKGVNINQKYSYALAVKLTAKEIAQPKLTLGTVTPGLRNYRKVVLATIRNPEPAVVSQLKLTTKVTRKGSSKVLYQNSSDNLIMAPNSNFTYPTFLDDQVMRAGDYTLSVTATTNDSKWAKKTWHWSRDFKITTEQARQNNQKAKNDPAAPISIWWYVLIVIVIAGLSAGIVYLIMKRHNRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM6</accession>
    <name>F9UNM6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two-component system response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rrp4</name>
        <name evidence="7" type="ordered locus">lp_1487</name>
    </gene>
    <organism evidence="7 8">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1487"/>
    <dbReference type="EnsemblBacteria" id="CCC78815">
        <property type="protein sequence ID" value="CCC78815"/>
        <property type="gene ID" value="lp_1487"/>
    </dbReference>
    <dbReference type="GeneID" id="66449375"/>
    <dbReference type="KEGG" id="lpl:lp_1487"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1249"/>
    <dbReference type="eggNOG" id="COG2197">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_9"/>
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    <dbReference type="PhylomeDB" id="F9UNM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1276-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
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    </dbReference>
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        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="24364" checksum="DC455CDA65ADCDBB" modified="2011-10-19" version="1">MYHVLIADDHAVVRSGLAYLINQQPNFEVIDEAADGTSTYLRVEQGDVDILVMDLSMPPGESGLITTQRIHEHFPDVRILILSMHEEQEYINKALHNGAMSYIMKSSSDDELLKALKTVANGEEYVDTNIVITKSDVQQINSNGVDTNLTGYNGLSKREREVFPLVALGYSNKEIAAKLFISTKTVEAHKANIMRKLALNNRADLIRYAIHHHLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
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    <name>F9UNN7_LACPL</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narH</name>
        <name evidence="2" type="ordered locus">lp_1498</name>
    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101444.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1498"/>
    <dbReference type="EnsemblBacteria" id="CCC78826">
        <property type="protein sequence ID" value="CCC78826"/>
        <property type="gene ID" value="lp_1498"/>
    </dbReference>
    <dbReference type="GeneID" id="49284218"/>
    <dbReference type="KEGG" id="lpl:lp_1498"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1260"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_9"/>
    <dbReference type="OMA" id="VYFNWQT"/>
    <dbReference type="PhylomeDB" id="F9UNN7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1287-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
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        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
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        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="519" mass="59012" checksum="ECA8E250D43F0D63" modified="2011-10-19" version="1">MKIKAQIGMVLNLDKCIGCHTCSVTCKNTWTNRPGAEYMWFNNVETKPGVGYPKRWEDEDHYKGGWELNSKGKLQLRAGNKVNKIALGKIFYQPDMPELDDYYEPWTYDYQTLFGPEKAHQPVARATSQITGLKMDLKTGPNWDDDLAGSPEYFKADPNMEKIETDIKANFEQAFMMYLPRLCEHCLNAPCVASCPSGAMYKRDEDGIVLVDQERCRGWRFCMTGCPYKKVYFNWKTHKAEKCTFCYPRIEEGEPTVCAETCVGRIRYIGAMLYDADRVEEAAETPEEDQLYQAQLDLFLDPNDPDIIEQALADGISEEMLEAAQNSPIYRMAVEEKIAFPLHPEYRTMPMVWYIPPLSPVMNYFEGRDSIKDPEMIFPGIDEMRIPVDYLASLLTGGNVPAIKGALYKLAMMRLYMRAKTGGKDFDAAKLQRVGLTENTATSLYRLLAIAKYEDRFVIPQNHKEQVEDAQSEQGGLGYDECAGCALAPQHGSMFKKAEAGESTNQIYAESFYGGIWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP67</accession>
    <name>F9UP67_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644348.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889520.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1704"/>
    <dbReference type="EnsemblBacteria" id="CCC79006">
        <property type="protein sequence ID" value="CCC79006"/>
        <property type="gene ID" value="lp_1704"/>
    </dbReference>
    <dbReference type="GeneID" id="57025336"/>
    <dbReference type="GeneID" id="66449571"/>
    <dbReference type="KEGG" id="lpl:lp_1704"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1440"/>
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    </dbReference>
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            <begin position="57"/>
            <end position="79"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="82" mass="8197" checksum="0C3790785D8186C4" modified="2011-10-19" version="1">MGWIGVAILGLTIGIVANAVGAHGRRQTTINLIAGLFGALGGQLSFGWFGPTVAGMTLLPVVSGAMILIVIGTVAAQALQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
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        <property type="protein sequence ID" value="CCC79008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="lp_1706"/>
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            <end position="77"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="CCC79008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9173" checksum="9240713FF9DB97FE" modified="2011-10-19" version="1">MHWLWVMIVGAAVGAFAGAIMSPSQSRGWIGHIIAGVLGALIGEGVLGPMGPELAGMTVIPAAIGAIAVVLIMMFVVQWARVRRSKHN</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889622.1">
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    <dbReference type="EnsemblBacteria" id="CCC79108">
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        <property type="gene ID" value="lp_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1833"/>
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    <dbReference type="eggNOG" id="COG4974">
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="32920" checksum="2AC5F043CEDD032A" modified="2011-10-19" version="1">MTAKFPYAKSFLASLETAGKQASTIEQYELTLADFFNYEQHFNETFAKDQLLADLTENDIQAYLAMLREQRQFKTSTLNKCLSNLNGYFSYLFSHRIITTLPTFTIKGQPLTNRQQTTTWPEQLAAWLAMDDLHPYTRLFLLLTTKGYTATEMLTPGFYQQLNAITFTAVEQAFLVKLRAYLQPLQTQSGSSDLFLKQRQRGTDPHLTLAALHKYLAGDSQRLGVPLKPVALRQDFMLWFLNQHRTTEPTEIMQQLRLDETSLEYYQNLLRQRDLRTLKATKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH8</accession>
    <name>F9UPH8_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1843</name>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101568.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1843"/>
    <dbReference type="EnsemblBacteria" id="CCC79117">
        <property type="protein sequence ID" value="CCC79117"/>
        <property type="gene ID" value="lp_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1843"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1554"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057834_1_0_9"/>
    <dbReference type="OMA" id="MTQHGFA"/>
    <dbReference type="PhylomeDB" id="F9UPH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1580-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="32675" checksum="646F1CB41ACE553C" modified="2011-10-19" version="1">MTVELKNEYLTVLINEAGAELSSVKSSDGIEYMWQADKTFWGRHAPVLFPIVGRLKDDQYTVAGQAYHMGQHGFARDNDFTVVNQTATQATFELTDSRATREMYPYAFRLRLIYTLTDHELTVNYNVHNPANQELLFSVGGHPAFNVPLADPAGTLADYKITVAPRKVYAHIPLQAPLNDAANADDFDLTKPLALSRDLFKDDALILDLNHHETTLMLDTDLDDHGVAMTIEDAPYVGMWSPYPAEAPFVCLEPWWGIADNVDSDGQLSHKMGINRLAANQTFDAKYAISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP3</accession>
    <name>F9UPP3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_1921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101592.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889696.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1921"/>
    <dbReference type="EnsemblBacteria" id="CCC79182">
        <property type="protein sequence ID" value="CCC79182"/>
        <property type="gene ID" value="lp_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1921"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1619"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_9"/>
    <dbReference type="OMA" id="FRRRGMY"/>
    <dbReference type="PhylomeDB" id="F9UPP3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1644-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="9"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="464" mass="49400" checksum="68373B0434D8B7A6" modified="2011-10-19" version="1">MEKRVDLKLILAIVAAGLLSFCGVIVETAMNITFPKLMREFALNTATVQWMTTAYLLVVAIIVPISAFLKRRFRTKTLFVTANLLFILGLVVDATATSFPVLVTGRIIQGLGTGIALPLMFNIIIDWAPARQKGTLMGIGTLITAIAPALGPTFGGLIVSWMDWHWIFVLLIPVLVISLVLGLYAIRQAQPTVKVGFDVVGWLMIVLLFVGFTIGFSKLATITTQPLIFVAWLVVGLIGLVGFVIRTRRAAQPLINLAIFTTKSYDLHLMAYFLVQICALGLAFILPNYIQLVNGKSALLAGLFVLPGAAIGAVFAPLGGRILDSLGAAKPVLTGSTILVIAMALFTVLGMHLSGGLILAIYILLMIGIGLTMGNTMTSGLQQLSAEHQADGNAVFNTMQQFAGAIGTSVVSAVITLVQVQTTGTSAHRTALGSTMALGLLLILVLIELGTMILAMKTRQAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR2</accession>
    <name>F9UPR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two-component system response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rrp6</name>
        <name evidence="7" type="ordered locus">lp_1942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889715.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1942"/>
    <dbReference type="EnsemblBacteria" id="CCC79201">
        <property type="protein sequence ID" value="CCC79201"/>
        <property type="gene ID" value="lp_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1942"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1639"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_9"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="PhylomeDB" id="F9UPR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1664-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="201" mass="22045" checksum="245FDEAE742B5F89" modified="2011-10-19" version="1">MITLYLAEDQSMLNSALTQLLELEDDLHVVGSAVDGINAWQELQELQPDVAILDIEMPGMTGLDVADRLASSQLATKVIVLTTFAQRRYFERAVKANVAGYLLKDSPSDDLIDAIRAVMTGRTIYAPELVTNMLSADNNPLTERELAVLVEAEKGLPTKTIAANLYLSAGTTRNYLSAIFSKLGVHNRLEAIRVAKANQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS1</accession>
    <name>F9UPS1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889724.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1954"/>
    <dbReference type="EnsemblBacteria" id="CCC79210">
        <property type="protein sequence ID" value="CCC79210"/>
        <property type="gene ID" value="lp_1954"/>
    </dbReference>
    <dbReference type="GeneID" id="57025535"/>
    <dbReference type="KEGG" id="lpl:lp_1954"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1650"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="IPCFAKR"/>
    <dbReference type="PhylomeDB" id="F9UPS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1674-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="299" mass="32957" checksum="4F6842FD6508AB2F" modified="2011-10-19" version="1">MNTPLLTVTQLNQYFSHQHILKALTFTIQKGHIVALVGANGAGKTTLMKSILGLTSFTGQIYLNGQSITPCHHQALSAVGALIEYPGLYPFLTGRQQLSLFATGANRTARVTKIIEALSMQAFADILTKHYSLGMRQKLGVALALLNQPALVILDEPMNGLDPQATKELRDLILWAQAQGTTFLISSHLLSELQRVANDVLVLDHGQLIANMSMPAFLAQQRPTYELVTNQDQRAYQLLRSAGYHLVAATPIRVLITPGFQLNPLLQLLLTNQIQLQRIQPHTEDLESSLLTMLKTVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX1</accession>
    <name>F9UPX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2013"/>
    <dbReference type="EnsemblBacteria" id="CCC79260">
        <property type="protein sequence ID" value="CCC79260"/>
        <property type="gene ID" value="lp_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2013"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1700"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195230_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1722-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="70" mass="8370" checksum="D8AEBD96F976B5EC" modified="2011-10-19" version="1">MTLKQAKRIMIKLRIRCQVHQKKHSRIKQQEQYLQDNVLNQHFSVNQPNQVWLADSTELTYGLMVSIKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX3</accession>
    <name>F9UPX3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889776.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2014"/>
    <dbReference type="EnsemblBacteria" id="CCC79262">
        <property type="protein sequence ID" value="CCC79262"/>
        <property type="gene ID" value="lp_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2014"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1701"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_41_7_9"/>
    <dbReference type="PhylomeDB" id="F9UPX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1724-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="79" mass="9364" checksum="1036813A0E58B546" modified="2011-10-19" version="1">MAQHEVTRSMPQPGTPYDNAPMEGWWNEFKLRWMDRHVKPATYQELVPLVEEGINYFNQLDRSPARNDLTPAEYWNEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ68</accession>
    <name>F9UQ68_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="synonym">dapA1</name>
        <name evidence="11" type="ordered locus">lp_2123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640801.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889871.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2123"/>
    <dbReference type="EnsemblBacteria" id="CCC79357">
        <property type="protein sequence ID" value="CCC79357"/>
        <property type="gene ID" value="lp_2123"/>
    </dbReference>
    <dbReference type="GeneID" id="57025663"/>
    <dbReference type="KEGG" id="lpl:lp_2123"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1798"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_9"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="PhylomeDB" id="F9UQ68"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1818-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="30593" checksum="2C57C1478688EED2" modified="2011-12-14" version="1">MNFANVDLMTAMVTPFDDHQQLDEKRLASLIEHLLAHGTQGILVGGTTGEAPTLTEDEKLTLLKKAAEIVDGRVPIVAGTGSNSTAATIAFTKKVSQIKGIDAALVVVPYYNKPDQAGMIAHFTAVADQGGLPVIIYNIPGRVIVKMTVATILTLAQNPNIIGIKQCATMEEFGAIVENAPADFLVYTGEDSQSLAAKEIGGAGVISVASHIYGDEMTAMFSAIDQGEIATAAKYQRDLTPKMSALFSAPSPSPVKAALNHLGQPVGEPRLPILPLSTEQTAQLFKTLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI1</accession>
    <name>F9UQI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641536.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889984.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2262"/>
    <dbReference type="EnsemblBacteria" id="CCC79470">
        <property type="protein sequence ID" value="CCC79470"/>
        <property type="gene ID" value="lp_2262"/>
    </dbReference>
    <dbReference type="GeneID" id="57025807"/>
    <dbReference type="KEGG" id="lpl:lp_2262"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1913"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_8_2_9"/>
    <dbReference type="OMA" id="GMQDTLT"/>
    <dbReference type="PhylomeDB" id="F9UQI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1955-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="32824" checksum="7E65FD0B3C7E0104" modified="2011-10-19" version="1">MFNSINLAAVDTPTKQVSVWMKLAKKIDWQQIIINIGGKLLEIILFILLFWVIDRLGKRLIHHLFLTNANTSDTANNRISTIFTLSLNIYHYVIMFFGIYAVLSVLGVPVGTLIASAGIFSVALGLGAQGFVSDIVTGFFILLEDQIDVGDYVKIETIEGTVSAIGLRTTQVTSPDGTLNFIPNRKILIISNQSRNDMRVLIDLYILTTTPVQDLTNVVRETNADLVPQYPDIIGEPDIQGVTTQADGTLVFRVQFYVKNGMQFAIQRDFLAAYLNAARAAGIQLPSPRLNIAPTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL7</accession>
    <name>F9UQL7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-proteolytic protein, peptidase family M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2306"/>
    <dbReference type="EnsemblBacteria" id="CCC79506">
        <property type="protein sequence ID" value="CCC79506"/>
        <property type="gene ID" value="lp_2306"/>
    </dbReference>
    <dbReference type="GeneID" id="57025842"/>
    <dbReference type="KEGG" id="lpl:lp_2306"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1950"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052943_0_0_9"/>
    <dbReference type="OMA" id="VYDDKMR"/>
    <dbReference type="PhylomeDB" id="F9UQL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1990-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="182"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="421" mass="46681" checksum="82EF0BC30802B827" modified="2011-10-19" version="1">MLQTQLAKGVQLTTVQSHQFKTNQIIINFRAPLARETITQRSLLSNLLETSSRDYPDQRALANALAAMYGAAFGAGVSRKGPTHNLQLAITVANERYLATDQPLTNQAIQFLQQVVLQPLVADGQFDQATFDRQKKNLEAAIMSVADDKQYYAAQQLNTALFADEPAQQVPSYGTASDLAALTAEGLYDYYQMMIQNDQIDIIVTGDVDEAAVLAQWQQAGFEDRLAGRPRPFYQHHNTNQYVEVSEQQALSQAKLNLGYDLPVFYRGNHYYAALVFNELFGGSPLSKLFMNVREKASLAYYASSSLDTFRGVLKVQAGIDGKNHDQVLAIIAAQLTAIQAGDFTDDLVEQLKLGLINDFESSLDSQRTFAVQALIDDLTQQRVTDTEWLRQIQSVTREQIIAVAKMVTLNNGFFLSGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQN5</accession>
    <name>F9UQN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signaling protein containing GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641476.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2330"/>
    <dbReference type="EnsemblBacteria" id="CCC79524">
        <property type="protein sequence ID" value="CCC79524"/>
        <property type="gene ID" value="lp_2330"/>
    </dbReference>
    <dbReference type="GeneID" id="57025861"/>
    <dbReference type="GeneID" id="66450072"/>
    <dbReference type="KEGG" id="lpl:lp_2330"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1969"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_2_0_9"/>
    <dbReference type="OMA" id="DNYIACS"/>
    <dbReference type="PhylomeDB" id="F9UQN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2008-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="44"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16526" checksum="1E96447BDB6EFDD0" modified="2011-10-19" version="1">MATTETSLMNQQLDALLFQETNLVANLANASALLNSTYDNLNWAGFYLFNEQTGELDLGPFQGKVACMHIKVGAGVVGTAFETQTNQRVADVHQFPGHIACDSASNSEIVVPITKDGHQIGVLDVDSPSLDRFNADNEAELTEFVAILTSHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ6</accession>
    <name>F9UQQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod-shape determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rodA2</name>
        <name evidence="7" type="ordered locus">lp_2354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890059.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2354"/>
    <dbReference type="EnsemblBacteria" id="CCC79545">
        <property type="protein sequence ID" value="CCC79545"/>
        <property type="gene ID" value="lp_2354"/>
    </dbReference>
    <dbReference type="GeneID" id="57025889"/>
    <dbReference type="KEGG" id="lpl:lp_2354"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1990"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_0_9"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="PhylomeDB" id="F9UQQ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2029-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="44530" checksum="211C9BC40BD347D2" modified="2011-10-19" version="1">MAEESRLRSQDEDSRIDWGIIFSVMMLGLIGLASIYVAAVHDSSSVNVTKQVISQVMWFVIGTAIAVIVMQFDSEQLWRVAPIAYWFGIFLLAAVLVLYSRSLFASTGAKSWFAVGSLTLQPSEVMKPAFILMLGRVVTMHNTEHPTHTMASDWQLIGKLIAYMVPVAILLKLQNDFGTMLVFFAILGGVILVSGISWRLLAPTFAIVAAIAGTALYLVISQSGRHILEAIGFKQYQFARIDTWLNPSTDTSNNAYQVWQSMKAIGSGQITGRGFNVSHVTVPVRESDMIFSVIGENFGFIGCAVVILLYFLLIYQMIRVTFDTKNEFYAYISTGVIMMILFHVFENIGMSIGLLPMTGIPLPFISQGGSALIANMAGIGLMMSMRYHYKSYMFSRNDRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU5</accession>
    <name>F9UQU5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101737.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890098.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2405"/>
    <dbReference type="EnsemblBacteria" id="CCC79584">
        <property type="protein sequence ID" value="CCC79584"/>
        <property type="gene ID" value="lp_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2405"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2031"/>
    <dbReference type="eggNOG" id="ENOG5033II5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378900_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2069-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="413"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="731" mass="81574" checksum="FC55FB187A607893" modified="2011-10-19" version="1">MNIDDHTLATNELAVLPLNHNWYQKVASNFEILQQYLNVFNGLGYYPNVGIISAGTLTIDLLNKHVDLRAGTMIERIGSAEVKVPTNVGIDLTNLGSVDYLVYDIQTNALMELSAIDKLKSTQILLNAIADQQLVFAYNRHTTKLFNSSEMMAPTNRATVVGDTIYVDWDQSAILIPKTTLIETTDNQFYTAKTDTDTRLDFSEYRNKGVDFMLIYDTLAKKYALSEIANQDYVTTNQGLYNSQLLLCIVNSNGLKLVEHGSNIVMKPFGESKQGNVTILNGTLTIDTNAHTIAFSDDFILGLTQAGRFQSLNHANNLTYQDKATGSAINTLYYHITLTERYFYVDVYPHNVDDFRILTFWNGKVFGIDDLDRVIVNGVGNGGRAALINKIDLRQLSTMMYSKEHPTVKIANLGDSTYQITGVSSTNGRWSDLLQPALIAETGNPNIKVVNGGFSGKSIQWIHDNFDTYFGHGKQFDGVQFVILGMGLNNATEFYNLDVIKGITKDVIQKIQALGMSVVLATTQANNLTTLSDRQEWYMYAAENAMRKELAHEMNLQLLDLNDATQKFLQYSHVKNSEITFDGLHFAPRGHQFEADWFESQLLTRPITITDNFQVDSTVQNTKSSAPQDWVVDNPNFTDGFKTKFNTSNNKGDTMLLDTLIMNMNTNPKALIAYTGPQNNGAYAVINGKKYPLSTGKTVLLDYAEMGLYHIKIMSGANNSVDVEGLKFKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR43</accession>
    <name>F9UR43_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890196.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2516"/>
    <dbReference type="EnsemblBacteria" id="CCC79682">
        <property type="protein sequence ID" value="CCC79682"/>
        <property type="gene ID" value="lp_2516"/>
    </dbReference>
    <dbReference type="GeneID" id="58789812"/>
    <dbReference type="GeneID" id="66450234"/>
    <dbReference type="KEGG" id="lpl:lp_2516"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2119"/>
    <dbReference type="eggNOG" id="ENOG5030AE6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3044634_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2175-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="54" mass="6273" checksum="6C21078C9B9CF671" modified="2011-10-19" version="1">MRVTINRGQEVYTDIPLMTARHRYIKADVWEIKKAIIEKSAINGWTVQALQAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR65</accession>
    <name>F9UR65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase,3-hydroxyisobutyrate dehydrogenase family</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890218.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2548"/>
    <dbReference type="EnsemblBacteria" id="CCC79704">
        <property type="protein sequence ID" value="CCC79704"/>
        <property type="gene ID" value="lp_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2548"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2140"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_9"/>
    <dbReference type="OMA" id="WSSEVNN"/>
    <dbReference type="PhylomeDB" id="F9UR65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2196-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="30220" checksum="4E94C0BE8CD1395F" modified="2011-10-19" version="1">MKLGWIGTGVMGAAIVRNLMTAGYDVTVYNRTKSKADALVAAGATWADTPAAVAETSDVIFTMVGFPRDVEQVYFGDHGIFSGLAAGKTVIDMTTSQPKLAVKIATYACEHDMHALDAPVSGGDIGAKNATLTVMVGGDADTYEAMLPLFNVLGHKVNHFGDAGTGQHAKMANQIMIAGTMTGLTEMLLYTKAAGLDPEKVLATLSSGGADNWSMDNYVPRILKDDYTPGFFARHFLKDLRIALSEADAMGLNLVATAQAKRLYEVMVDVKGLGDQGTQGLINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR89</accession>
    <name>F9UR89_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, MMPL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101832.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890242.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2575"/>
    <dbReference type="EnsemblBacteria" id="CCC79728">
        <property type="protein sequence ID" value="CCC79728"/>
        <property type="gene ID" value="lp_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2575"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2164"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323329_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR89"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2220-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="51"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="894" mass="99030" checksum="C4FF943F7B052831" modified="2011-10-19" version="1">MRKLLKPKWLFLFFWGIVVFASILILPNITTFVNEQTAMPQDATTSPKYQQQWGHGLTNSQSLTLVFNNSNGKLSKQQRQQISTTLAKLNRRADDYGINQLRTPTGMTNDRHLLRSNDGSTELALVAVQTSRADLSVIANQLNNAISIADLNTSVTSTDLIYQQHVQQQRRNLLISMLIGSLLSLIILGLIFRSLLVPLLNLLCQVVTLITTISFITNARLAWHWPLTANALSLAGLISLILTSLLTWHFMYAYWQSSATTAPTTVSLKILTLQYRQWALVFIPLILITITLHWTAFISLAAAWAITVALGITLLAVPPLNYAFTAWLGDNLFWPGTTAWPTRPRNLWGQLSKFGYWQPALGSLAVALLLLPGLILANGQFADDNLRPWRQNQLSNAELGQQLVQAHFGTGATAPITITLRAPQNLTQQQSLQTIDHLTTKLRAVPNVAQVISVTQPTGQPLSTFYVNQQLATINIDLAGKLTSMAKLKSQLTTDQQSLEQAATSRHTKSVDQLSDRINDLAELNDQVQRQLQAIDTTLTTSAEAEPDLTKVNQQVTKLDHLTDRMTTALNHVVTAQTTVATEAGHVDQRVHHVNQSLKQTVQPLTTLLASLKNTKTYLHDLAASQVGRSFYLPANAATNQAYQNSLFTNISSDLSMTQLTVTLKSAPASAASRRTLQRLQAVTHDSLLATPLAHAKILTTGVTQQQHYQHTLIATHALRWLTLGLIIGIVVLWFGLRSLTFSLLMTACLTGVTLTSWGWTQLILTRWLQTGPLSSSVLLGSLMLLTLHWLMITTATGYRQSWLRHLEPAHLQQHFYTSGRFVCPVTMIELTYLLPLLLTTAPTLKGLALMSLIGITISNLIVPLGFSGWTRWANEPPAIATLWQHFRPSSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD0</accession>
    <name>F9URD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2631"/>
    <dbReference type="ESTHER" id="lacpl-LP.2631">
        <property type="family name" value="5_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79769">
        <property type="protein sequence ID" value="CCC79769"/>
        <property type="gene ID" value="lp_2631"/>
    </dbReference>
    <dbReference type="GeneID" id="57026029"/>
    <dbReference type="KEGG" id="lpl:lp_2631"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2207"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094948_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9URD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2260-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="71"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="28360" checksum="46124B7BF57870DD" modified="2011-10-19" version="1">MTTNLFEDVVVRTTKFGDLPVLHVFAASQAQTKLPTIIDYHGWTNQTATELGTAYQLVRAGFRVILPTAYLHGSRNDGTDLDRHPEHFWSIVGHSVAEFPQLVAALVAAGISDANKIGVMGTSMGGITAAGIMATQPTVVAGVSLIGSPEPVAFATDQVAQLPAALQAKLPAELIEQTYQQLAKFDLSEHPEALAGRPMFFFNGTADQMVPYQYIRDFKHRFKDEPALKATVFKRAEGGVHHVPHKIQEAAVAFLETNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK2</accession>
    <name>F9URK2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">purS</name>
        <name evidence="6" type="ordered locus">lp_2726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642588.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890355.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2726"/>
    <dbReference type="EnsemblBacteria" id="CCC79841">
        <property type="protein sequence ID" value="CCC79841"/>
        <property type="gene ID" value="lp_2726"/>
    </dbReference>
    <dbReference type="GeneID" id="57026101"/>
    <dbReference type="GeneID" id="66450378"/>
    <dbReference type="KEGG" id="lpl:lp_2726"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2281"/>
    <dbReference type="eggNOG" id="COG1828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164833_3_1_9"/>
    <dbReference type="OMA" id="IENYRFE"/>
    <dbReference type="PhylomeDB" id="F9URK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2332-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="84" mass="9754" checksum="03285ACC249D2604" modified="2011-10-19" version="1">MYLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVAAEIDEMCDRLLANVNMETYRYEITEMEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK5</accession>
    <name>F9URK5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">lp_2729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2729"/>
    <dbReference type="EnsemblBacteria" id="CCC79844">
        <property type="protein sequence ID" value="CCC79844"/>
        <property type="gene ID" value="lp_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2729"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2284"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_9"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="PhylomeDB" id="F9URK5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2335-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="16931" checksum="938D50EE51DE7A9D" modified="2011-10-19" version="1">MMAKVGLIMGSISDWPTMQLAAEQLTALGVSYERHVISAHRMPQTLQSYGEEAASRGIQVIIAGAGGAAHLPGMLAANTLLPVIGVPIKTHTLNGVDSLLSIVQMPAGVPVATMAIGDAGAKNGALMAAQIIGLREPQVQHAIGEFRARQRQEAEQSERQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP7</accession>
    <name>F9URP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbg5</name>
        <name evidence="3" type="ordered locus">lp_2778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2778"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79886">
        <property type="protein sequence ID" value="CCC79886"/>
        <property type="gene ID" value="lp_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2778"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2326"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="GMHAPGY"/>
    <dbReference type="PhylomeDB" id="F9URP7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2377-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="479" mass="54896" checksum="777331249D6C8FC2" modified="2011-10-19" version="1">MTKGYKMPKDFLWGGAVAAHQLEGAWDVDGKGVSIADVMTAGRNGVPRKVTDGVKDGEIYPNHWGNDFYHRYSEDDRLFEEMGFKCFRTSIAWTRIFPNGDESEPNEAGLKFYDDLFDDLLSHGIQPVVTLSHFEIPYHLVKAYGGFSNRKMIDFFVHFAKTVFKRYQDKVKYWMTFNEINNQTAWSDPHPLLQNSGLQLSKDDNWEQAMYQAAHYELVASALAVQAGHAINPDFQIGCMVAMCPIYPLTAKPADVMMAERAMQKRYWFGDVHCLGEYPKWLPKYFERKGFDMDITAADLATLKAGTVDYVGFSYYMSFVTKGRDGDSDYDFKEPDDFVENPYVEKSDWGWQIDPTGLRYAMNWMQDRWHLPQFIVENGFGAYDKKEADGSVHDDYRISYFRDHILAMEQAVVLDGVDLIGYTPWGCIDLVSASTGEMAKRYGFIYVDADDNGQGSFDRSKKDSFNWFQQVIASDGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ0</accession>
    <name>F9URQ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gntR</name>
        <name evidence="2" type="ordered locus">lp_2782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642541.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890403.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2782"/>
    <dbReference type="EnsemblBacteria" id="CCC79889">
        <property type="protein sequence ID" value="CCC79889"/>
        <property type="gene ID" value="lp_2782"/>
    </dbReference>
    <dbReference type="GeneID" id="66450427"/>
    <dbReference type="KEGG" id="lpl:lp_2782"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2329"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_1_9"/>
    <dbReference type="OMA" id="YEVRSHE"/>
    <dbReference type="PhylomeDB" id="F9URQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2380-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="27009" checksum="CD95830ACCBCB425" modified="2011-10-19" version="1">MYRDIATKLVAAIQDGIFTVKLPTEAQLMERYQASRNTIRKAIDLVYQQGLLRRVQGSGYYITNIQLQHKTVVNLSARSLFNSHVHPRTLTSKILTFDTIHGDSALSRKLNIPVDEELYRIIRLRYWHDQLYCLEKAYYLRSVVPYLSTEAVNTSIWDFINEAYGIGIANSDDYLSLTNLNKEEAELMNLAQGATHLALDSCNYYKNNGLLDFSHTIFVYPDLALYFHTTNLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS2</accession>
    <name>F9URS2_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Extracellular protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_2809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890425.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79911">
        <property type="protein sequence ID" value="CCC79911"/>
        <property type="gene ID" value="lp_2809"/>
    </dbReference>
    <dbReference type="GeneID" id="57026176"/>
    <dbReference type="KEGG" id="lpl:lp_2809"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2351"/>
    <dbReference type="eggNOG" id="ENOG5030PJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249326_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2407-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394404" evidence="1">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="23206" checksum="0D849AAED482ABA3" modified="2011-10-19" version="1">MNFKRKIQLGIATATGMLVVGIVAVPSVTNVLHAASDSVSLVSQTAAPTTVKATNQTVKAISASGTKGNYRVKYAKAGTSSTTATYQQTNYNTKSDASSQVDYLANTQGQRTTLNSGTAATVQGTMGKVYVHWNTGSWSVTTIANTQDVAGNPTKFANQVNNQIQKQDLTSKNVTSGAVTVYDTPQNGQANSVQWQNGKQVAKVQGQQANTVIKIAADAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT0</accession>
    <name>F9URT0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890433.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2822"/>
    <dbReference type="EnsemblBacteria" id="CCC79919">
        <property type="protein sequence ID" value="CCC79919"/>
        <property type="gene ID" value="lp_2822"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2822"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2360"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060907_2_0_9"/>
    <dbReference type="OMA" id="RINGKNQ"/>
    <dbReference type="PhylomeDB" id="F9URT0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2416-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="355" mass="38130" checksum="ADB0858B82184073" modified="2011-10-19" version="1">MYLGLKEMAHEKLRYGLLSGVLLLIALVVFMLAGLANGLSNGNRQAVDQWHAQTVYLNEDANQTLSASQLKLADQERIKGQDVAPLASLSGTLRTASNGQKTNASAFGTTRDSFLMPKVVSGHRINGKNQLLISAGLKDKGYRIGQKVRIGTTDQKVTIVGTFKASTYSIAPTVYTDVATLNRLKGNPVTSGDQQPVNAFVTKKSHFKNQHHGNMQRLSIATFIEKLPGYSAEQLTLNTMIYFLFAIALAVIGIFMFVLTLQKQALFGVLKVQGIGTKHILAALLTQSVVMAIIGIGIGLLITLGLAQIMPAGLPFAIDWPQFGIYSVALLLAAVVGALLSWRTVAKIDPVVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU9</accession>
    <name>F9URU9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase, with LysM peptidoglycan binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890452.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URU9"/>
    <dbReference type="STRING" id="220668.lp_2847"/>
    <dbReference type="EnsemblBacteria" id="CCC79938">
        <property type="protein sequence ID" value="CCC79938"/>
        <property type="gene ID" value="lp_2847"/>
    </dbReference>
    <dbReference type="GeneID" id="57026203"/>
    <dbReference type="KEGG" id="lpl:lp_2847"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2380"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077123_0_0_9"/>
    <dbReference type="OMA" id="NTPVFNH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2435-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394405" evidence="2">
        <location>
            <begin position="27"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="354" mass="35025" checksum="FC30E298347D11E0" modified="2011-10-19" version="1">MKIKHLLLSSLATTGAIALGATAAKADTVTVKAGDTVSEIADTHKTTVAAVQKLNHLKNVNLIYVGDKLQVNKHQTVKMTRATTSVATPSTTTTITSAAVQNPTSTVTATSTVSQSTASQASASSVTSAASQSSTSAVSQSSTSQNSASSVTSATSQSATSAVSQSSTSQASASSVTSTTSQSATSATSQSSTSQASASSVTSTTSQSATSAASQSSTSQASASSVKSAASQSTTVTSQSTTTTASSAATSSASTSSTTASQASSSTASSTTSTTTSSTSTSEAAAKAWIAARESGGSYTVTNGIYYGKYQLGQSLLNGDYSAANQEATADAYVAGRYGSWTAAKAFWQANGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX8</accession>
    <name>F9URX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, subfamily IA</fullName>
            <ecNumber evidence="1">3.1.3.35</ecNumber>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.35" evidence="1"/>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101948.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2879"/>
    <dbReference type="DNASU" id="1063261"/>
    <dbReference type="EnsemblBacteria" id="CCC79967">
        <property type="protein sequence ID" value="CCC79967"/>
        <property type="gene ID" value="lp_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2879"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2410"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_9"/>
    <dbReference type="OMA" id="LCENLQD"/>
    <dbReference type="PhylomeDB" id="F9URX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2464-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050340">
        <property type="term" value="F:thymidylate 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="227" mass="25426" checksum="089DDEBC912DE224" modified="2011-10-19" version="1">MQYAIFDLDNTILDFDRAEAANLAAVFQHHGVTDIRRAENEYQAYNETVWQQIEQGADRDSLLDQRFQVFLGTLGITVDGPAVQQEYDQLLAHSYQVIPGAHELLRTLTNAGLTLLVGTNGIKHTQLSRLAGAHMTPYFDHIFISESIGYAKPNPHFFNAIHDQYPDMNATNTVMIGDSLRSDIAGAATVQLPSIWYNPQHVHNDTTIAPTYTVDNFKQLQKLLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY5</accession>
    <name>F9URY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101955.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890488.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2889"/>
    <dbReference type="EnsemblBacteria" id="CCC79974">
        <property type="protein sequence ID" value="CCC79974"/>
        <property type="gene ID" value="lp_2889"/>
    </dbReference>
    <dbReference type="GeneID" id="66450511"/>
    <dbReference type="KEGG" id="lpl:lp_2889"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2417"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065086_0_0_9"/>
    <dbReference type="OMA" id="FKWKYPL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2471-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022208">
        <property type="entry name" value="DUF3737"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12541">
        <property type="entry name" value="DUF3737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="32703" checksum="B4E15565C1591664" modified="2011-10-19" version="1">MKTITQQYLTGERALFKAHDLEIDNTTFADGESPLKESRNVTLKQPIFKWKYPLWYSQHVTVDQGLFETMSRSGIWYTKDITITNSTLQAPKLFRRASQVKLAHVHFSDAEETLWNCQDITLNDVQAAGDYFGMNSQNIRIDGFNLVGNYAFDGAKNVEIHHATLMTKDALWNCENVTVYDSQIIGEYLGWNSKNIRFVNCTIESDQGLCYMDNVKLENCTLLNTDLAFEYCRNIDADVVSTIDSVKNPLSGRIHAQAIGEIIMDDPEVDPHQTLISVDHESRAPHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9US06</accession>
    <name>F9US06_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Proline iminopeptidase</fullName>
            <shortName evidence="9">PIP</shortName>
            <ecNumber evidence="4 9">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pepR2</name>
        <name evidence="12" type="ordered locus">lp_2919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the N-terminal proline from various substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101971.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890509.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US06"/>
    <dbReference type="STRING" id="220668.lp_2919"/>
    <dbReference type="DNASU" id="1063330"/>
    <dbReference type="EnsemblBacteria" id="CCC79995">
        <property type="protein sequence ID" value="CCC79995"/>
        <property type="gene ID" value="lp_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2919"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2437"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_0_9"/>
    <dbReference type="OMA" id="TEYIPHI"/>
    <dbReference type="PhylomeDB" id="F9US06"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2491-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031975">
        <property type="term" value="C:envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="34596" checksum="F3C4B12FA26A0856" modified="2011-10-19" version="1">MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMYDQLGSWYSDTPNWDDDAIRQQYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYAADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENAFMLAIEKRQQWNNPHYRQLITHLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTLLMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9US78</accession>
    <name>F9US78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888139.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1061223"/>
    <dbReference type="EnsemblBacteria" id="CCC77625">
        <property type="protein sequence ID" value="CCC77625"/>
        <property type="gene ID" value="lp_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0058"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.47"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105338_1_1_9"/>
    <dbReference type="OMA" id="NGNTQAF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-47-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="15140" checksum="B6FA03B9E63A644C" modified="2011-10-19" version="1">MTVAIRYQTRNGNTQAFAEQIASVAGVPAQSIDTPVEQADTLFFGGGTYFMKPDKTASAFMKNLDPTKIKQIALFTTSGGPEMVSDKALTKIATEKGIPVIGHFHQVMGGKGMKIIGSTGGKLKDEQIELVKEFAQKMLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA8</accession>
    <name>F9USA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscD family,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890552.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2976"/>
    <dbReference type="EnsemblBacteria" id="CCC80038">
        <property type="protein sequence ID" value="CCC80038"/>
        <property type="gene ID" value="lp_2976"/>
    </dbReference>
    <dbReference type="GeneID" id="57026310"/>
    <dbReference type="KEGG" id="lpl:lp_2976"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2483"/>
    <dbReference type="eggNOG" id="ENOG5030BHP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989819_0_0_9"/>
    <dbReference type="OMA" id="GVQANHY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2534-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389082" evidence="2">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="13687" checksum="1C9F789732B0B8D2" modified="2011-10-19" version="1">MMRWLLIRGLLGLLIGLGPSIGGAAQTVGTSSTQIQFYTSRSADKQAPTTVQQIPQGDVVYATKAVKAAPNRFVGQWQQVLATGRLPQTGVQANHYYQWLGFLTLMALLLGWQVLKLMRERGANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE2</accession>
    <name>F9USE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase, with LysM peptidoglycan binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643362.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3015"/>
    <dbReference type="EnsemblBacteria" id="CCC80072">
        <property type="protein sequence ID" value="CCC80072"/>
        <property type="gene ID" value="lp_3015"/>
    </dbReference>
    <dbReference type="GeneID" id="57026342"/>
    <dbReference type="KEGG" id="lpl:lp_3015"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2518"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077123_1_0_9"/>
    <dbReference type="OMA" id="WEHIIAH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2566-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394316" evidence="2">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="23162" checksum="296E798101FC2A71" modified="2011-10-19" version="1">MKKLLTTILTTSAATVGLLLAGTVSAHADATYTVKKGDCVWAISQEYKTTIESIETANNIHGHLILPGQQLRIPGVNAQDLTSQAPATPVVSAPVQQAPVTTPTQPAETQAATTTQTTPAQTNETVASAPATTPATESYSGDNLQSYVLGQMQARTGVDAGTWNHIINRESNWQPHVVNGASGAYGLFQNIHISGGSVQQQIDAAVNLYHAQGMQAWALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE4</accession>
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        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890588.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_3017"/>
    <dbReference type="EnsemblBacteria" id="CCC80074">
        <property type="protein sequence ID" value="CCC80074"/>
        <property type="gene ID" value="lp_3017"/>
    </dbReference>
    <dbReference type="GeneID" id="57026344"/>
    <dbReference type="KEGG" id="lpl:lp_3017"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2520"/>
    <dbReference type="eggNOG" id="COG4043">
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    <dbReference type="HOGENOM" id="CLU_139906_1_0_9"/>
    <dbReference type="OMA" id="QAMYEQI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2568-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016645">
        <property type="entry name" value="UCP016134"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016134">
        <property type="entry name" value="UCP016134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="12654" checksum="B423C39C1FB2EAB2" modified="2011-10-19" version="1">MTTMQLIHPQWLLIKSGLKTIEIRLNDAKRQALQVGDIVNFIDLTTGQQLTTQLIDITRFASFESLLSEYTAVQVGSAPGTPVTQMVQEMLTLYSPVQVAQSGVVALQVRPLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE6</accession>
    <name>F9USE6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102007.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3019"/>
    <dbReference type="EnsemblBacteria" id="CCC80076">
        <property type="protein sequence ID" value="CCC80076"/>
        <property type="gene ID" value="lp_3019"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3019"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2522"/>
    <dbReference type="eggNOG" id="ENOG5030A9F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501682_0_0_9"/>
    <dbReference type="OMA" id="MRTILAQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2570-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="20121" checksum="48428C43227B5D68" modified="2011-10-19" version="1">MKKILIPIITVLIIGTIVGLSTLHRTPRATTTTVHKSRVIQQPQPITETTIAKQPALKYSCIIYYAIKHLKIQRWQEVSDFSLGWQVEIYTDQGQTKYLVWSDKHIKADAKQLQPNWFTLKNDQVTYDSFGVHTFKKDLTATVSMRTILAQIKRDHATKTVRHMPTNLVIKDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF3</accession>
    <name>F9USF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3026"/>
    <dbReference type="EnsemblBacteria" id="CCC80083">
        <property type="protein sequence ID" value="CCC80083"/>
        <property type="gene ID" value="lp_3026"/>
    </dbReference>
    <dbReference type="GeneID" id="57026353"/>
    <dbReference type="KEGG" id="lpl:lp_3026"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2529"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_9"/>
    <dbReference type="OMA" id="ANVQFMT"/>
    <dbReference type="PhylomeDB" id="F9USF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2577-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="26368" checksum="1A3DA6358E001D42" modified="2011-10-19" version="1">MSVKNKVIVITGASSGIGEASAKLLASHGAKVVLGARREQRLQKLANKIQQQGGQATYRVTDVTKPEDLTALVALAKREFGGIDVIFNNAGIMPTSPISALKTDEWNAMIDVNLKGVLNGVAAVMPDFTNQKYGQIITTSSVAGLKSFAGSGIYGATKFAVRNLMEVIRMESAQEHTNIRTTSLYPAAINTELLHTITDTNAKQGMNKLYASVGITPDAVARVVDFAVAQPDDVNVNEFTIYPTKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG3</accession>
    <name>F9USG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642293.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890607.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3038"/>
    <dbReference type="EnsemblBacteria" id="CCC80093">
        <property type="protein sequence ID" value="CCC80093"/>
        <property type="gene ID" value="lp_3038"/>
    </dbReference>
    <dbReference type="GeneID" id="57026361"/>
    <dbReference type="KEGG" id="lpl:lp_3038"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2539"/>
    <dbReference type="eggNOG" id="ENOG5032UTZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058980_0_0_9"/>
    <dbReference type="OMA" id="PYWYNNN"/>
    <dbReference type="PhylomeDB" id="F9USG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2586-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="396" mass="44766" checksum="E8F17A56A62E2500" modified="2011-10-19" version="1">MAGQEQQVRVSIPVSALKRAGIDRDDQLQLKVRNDALVLEKIKPRQPQWQQYLIIWPLLVAILSGLASYGYWWFQKVRPVPLTGAQSIGSLTIVAGVVTGAVLFVGFFLKTRNDPENRFSRHIYWRNFPVITIAFIMILAFALVGAFWVLELLFPDVIFDRFTSMLLLVLFTYFADAFMISAALTINARSLSTILTVVIVSGCVISMAANGQRRWWQHNLSFLGTHAAENAWQFNLTLIFSALLMVVLIDYLFVSLSRIYPRTWRTSTLRILLTLTAVDFGAVGLFPNNLTFHWLHDLVAGGLVTLLVLLIVGVRWLLPAVTKDFLWLSYGVGVVLLLLNFGFRWFGYPSLTAFEIQAFAISFGWLLMLFSRLQALVNEDPELLTIKLEQESTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ1</accession>
    <name>F9USJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscD family,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642325.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3074"/>
    <dbReference type="EnsemblBacteria" id="CCC80121">
        <property type="protein sequence ID" value="CCC80121"/>
        <property type="gene ID" value="lp_3074"/>
    </dbReference>
    <dbReference type="GeneID" id="57026390"/>
    <dbReference type="KEGG" id="lpl:lp_3074"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2568"/>
    <dbReference type="eggNOG" id="ENOG5030A79">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144100_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2614-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394321" evidence="2">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="13297" checksum="884257F73F40ECAC" modified="2011-10-19" version="1">MKRLGFITIAISTLLCWGWLSAPIIGVASTAESPATIRFDGQAESSNSDTGANQLQVTEASKSSHSIVHQPNASQAVHHQNPGWLPQTSEQWWLSAFIGGIGLLVVLIGWQLVNYLKKRSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM6</accession>
    <name>F9USM6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890670.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3113"/>
    <dbReference type="EnsemblBacteria" id="CCC80156">
        <property type="protein sequence ID" value="CCC80156"/>
        <property type="gene ID" value="lp_3113"/>
    </dbReference>
    <dbReference type="GeneID" id="57026422"/>
    <dbReference type="KEGG" id="lpl:lp_3113"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2602"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_1_9"/>
    <dbReference type="PhylomeDB" id="F9USM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2649-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14941" checksum="ABF78BD960E7F009" modified="2011-10-19" version="1">MLTFKIPEQQHYFTTKEVTAMTGMTKDALRYYEHLGILPDVQRNQYNYRQYSHKNLETLQLIKIFRDLDLDLSLLTPAHLALDGQAKVVAFKQYQQVIRDRIRHLEAIDQLLATKIDYFEHQSIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM9</accession>
    <name>F9USM9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3116"/>
    <dbReference type="EnsemblBacteria" id="CCC80159">
        <property type="protein sequence ID" value="CCC80159"/>
        <property type="gene ID" value="lp_3116"/>
    </dbReference>
    <dbReference type="GeneID" id="57026425"/>
    <dbReference type="KEGG" id="lpl:lp_3116"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2605"/>
    <dbReference type="eggNOG" id="ENOG50324R5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_5_0_9"/>
    <dbReference type="OMA" id="YTTTLTW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2652-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394324" evidence="1">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="18497" checksum="01E0EEA8163C7B7E" modified="2011-10-19" version="1">MKKFVLGLMISAGLLGATTVVANADTTGSSTGDVTFTGGTLSMSVDATHLAFGSNTISSSDATLATSSTPTVTVSDLRGTSAGWTLTVAQGQQFNTALNGTGSSLINAALTVAGTESDSAVTNGSTTLTPGTTSAAGAAGTVASAKNGTGNGASTVTFSDSKLAVPGKTTKLATGYTTTLTWNLNDTPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ4</accession>
    <name>F9USQ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3145"/>
    <dbReference type="EnsemblBacteria" id="CCC80184">
        <property type="protein sequence ID" value="CCC80184"/>
        <property type="gene ID" value="lp_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3145"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="AIMKNGH"/>
    <dbReference type="PhylomeDB" id="F9USQ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2677-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="180" mass="19087" checksum="85CF012CDBF166F6" modified="2011-10-19" version="1">MKKIIVNEYGSVDVLQEVVALKPVPGEKDVLIKVAAIGVNDPDIVMRKYGPFPTMPAEFRPTLPHMLGGDFSGIVEQVGAEVTKFQVGDHVMGYTKRGTYAQYIVLDQDDSLSQVPDQLDLIPLGGLYLTALTAWSAIMKNGHLQAGQKVLIHGGAGGVGSMAIQIAKAAGATVITTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS2</accession>
    <name>F9USS2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888167.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77653">
        <property type="protein sequence ID" value="CCC77653"/>
        <property type="gene ID" value="lp_0096"/>
    </dbReference>
    <dbReference type="GeneID" id="57026938"/>
    <dbReference type="KEGG" id="lpl:lp_0096"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.76"/>
    <dbReference type="eggNOG" id="ENOG50309I8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114708_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-75-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="27283" checksum="3CFB31D875DF626E" modified="2011-10-19" version="1">MSFRVVAGYFGEFSDEAKRANQDLGVIGMSFQYQCNLVYPEGAGPNFGFRTDAQAIDVFDALKVGYDGFKVQAGLIKAMGLVDYQLVGGRYELVGHDFRELPLAEINANLETMPGLLAQGPMPVRYVTYRRTDDPIDAVGFSGNWALGDSGGFRQLSETLAEPMQAPVAALIKAIDQLGLTLQQINLPTPQSSTALPTHLSDDVHQANVDVWVVLTQPQGDEQQVLQTIHNAQECNEKLCEALTRVYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX5</accession>
    <name>F9USX5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641758.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0162"/>
    <dbReference type="EnsemblBacteria" id="CCC77706">
        <property type="protein sequence ID" value="CCC77706"/>
        <property type="gene ID" value="lp_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="57026993"/>
    <dbReference type="KEGG" id="lpl:lp_0162"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.131"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_45_0_9"/>
    <dbReference type="OMA" id="ALKFLMW"/>
    <dbReference type="PhylomeDB" id="F9USX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-128-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="24905" checksum="5CF34DE92CC49AF9" modified="2011-10-19" version="1">MAVKQPVPKDPAKVERIMHAAMHTFAVSGYRDAKTDVIASAATVSKGLLFHYYGSKQRLYLATVQLATDTIIATINQQVFDVPDDLVTLMVRSARYKAAFGKDHPDEMKVLIDAYGALERLPVKIQAQMKILYTKSMTISREMISQVLDKMTLRADVDRDATIALIMGVYNQIFMEFQTYMRENHQVESMADIEWVVSRAKTYMGILEHGFMAADLDDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX7</accession>
    <name>F9USX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1393 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641760.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0164"/>
    <dbReference type="EnsemblBacteria" id="CCC77708">
        <property type="protein sequence ID" value="CCC77708"/>
        <property type="gene ID" value="lp_0164"/>
    </dbReference>
    <dbReference type="GeneID" id="57026995"/>
    <dbReference type="KEGG" id="lpl:lp_0164"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.133"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098232_3_0_9"/>
    <dbReference type="OMA" id="INYWSLA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-130-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030949">
        <property type="entry name" value="ECF_S_folate_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04518">
        <property type="entry name" value="ECF_S_folT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="18993" checksum="AB1F453FEC61E422" modified="2011-10-19" version="1">MTSSLTVRRIPLLGALIAMQLILGSLLSIQLLLTKISFAFIIIGLTARLFSPLVTAGSSAISSLLGMLLFPKFTFFPGFILTAFLTGLVFGYAFQHQTSLTRVLVANFIVVFILNLFLNSLWLHLMYLTPWSVLLTTRMIQEVITYVCYSVILIALFKIPILNQLTARFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT38</accession>
    <name>F9UT38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0237"/>
    <dbReference type="EnsemblBacteria" id="CCC77769">
        <property type="protein sequence ID" value="CCC77769"/>
        <property type="gene ID" value="lp_0237"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0237"/>
    <dbReference type="eggNOG" id="ENOG5030AI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193616_0_0_9"/>
    <dbReference type="OMA" id="IAIFSTW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-191-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="12536" checksum="A45E3013C0758B5B" modified="2011-10-19" version="1">MNSFKNPLMTTPYLLAIIATLTMLVSPLTTVVISVLIWLSGITLVWLHRQQRWLRFFYAPVFLYTFLLEQRYFSPSTQPLTETILINLAILGIAIFSTWAAYQLRHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT55</accession>
    <name>F9UT55_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepM</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ordered locus">lp_0257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888300.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0257"/>
    <dbReference type="EnsemblBacteria" id="CCC77786">
        <property type="protein sequence ID" value="CCC77786"/>
        <property type="gene ID" value="lp_0257"/>
    </dbReference>
    <dbReference type="GeneID" id="57027076"/>
    <dbReference type="KEGG" id="lpl:lp_0257"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.213"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_9"/>
    <dbReference type="OMA" id="CITWPDN"/>
    <dbReference type="PhylomeDB" id="F9UT55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-208-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="29083" checksum="84AC475E083EE5EB" modified="2011-10-19" version="1">MITLKSDREIKGMQAAGDIMVGLFHALEDYIKPGITTWDVDHFAYEYIVAHDATPGELNFEGYKYSTCVSVNDMICHGCPSKDILVKDGDLLKVDTVINYHGYLSDSCHAFVAGTPSPEVKKLMEVTHKALYLGIDQAVVGNRIGDIGWAIQNYAENEMGYGVVREYIGHGIGPTMHEKPDVPHYGEAGHGTRLKAGMTITIEPMVNIGDWRSGETADDGWTVRTLDGSLSCQYEHTLVVTDDGPKILSSFDNDFDAKYLWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT66</accession>
    <name>F9UT66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-glycerol glycerophosphotransferase / glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
            <ecNumber evidence="7">2.7.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagF2</name>
        <name evidence="7" type="ordered locus">lp_0269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EC" id="2.7.8.12" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100946.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888311.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0269"/>
    <dbReference type="EnsemblBacteria" id="CCC77797">
        <property type="protein sequence ID" value="CCC77797"/>
        <property type="gene ID" value="lp_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0269"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.224"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009366_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-219-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="6">
        <location>
            <begin position="672"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="939" mass="108303" checksum="28553DD319F9D5DC" modified="2011-10-19" version="1">MGKMNTIKLACKFVARPIREFVTKPAIRQINVYLYYVKHSKVQEKAVFLESYHAVNLTGNVYAMYQKMVQEYPDYTYYWAYKDKDTIPADIMADTKRHRVYLVKYESRQYMKALATSKYLINDTSFMPYFIKRDGQRYLNTWHGTPLKTLGLDIKGSGRADHKNIQRNLLAADVLAMPNQFTAEHLITSHDLNGIFPNEVYITGNPRVDNLLGTLVSEDTQALKERLGLPAEKIILYAPTWKKDVEYTTEADILQLLNEVQRLQERVPSGYKVFLKVHYFIYDKLVEMGYGDQLISNAIDTNTLLRGVDVLITDYSSIFFDFLPIKRPVMFYVPDKDSYAQNRGFYKSLDTLPGLVTDKFDQLLDDCNQKYFDSWAKTYEQQYNDYKSEFLSYDDGQATDRAVQVLFEESSSIERLDFNNNKKKLLIYAGGFYNNGITNSIINLSRNFDTNKYELVFVDYPRMRPEKEYNMNRLPDSVHFIFNFSWATRTFFDTYNQNTSYHFGFNSKLVNQNKMKATYQLNFRRIFGNFMPYEVIDFGGYNKAITGLFALSPVPKKVVFLHNTMWDEYNKIVNGRYKHRKNLRVTFTYYQYFDKIISVSQSADKQNREDLSQYADSAKFTWVENLVNGAEIEKELSEVKQQVDNGDSLIELTKTETPSGIITTQLFHPVDQNYFNFVTVARLSPEKNHLGLIQAFKLVHDNYPKTRLYIVGNGPIRLEVEQLISGLGLDESVFMMGFLQHPMKFVSFTDYVVLPSVTEGQGLAIIEALLAHKPVVGTDVAGIQDVIKGGRFGLLSGKNAVANPNSLANTLALSIETKDSIKYVKTVKEPLKIFHAETQVDGKWVTSSDDWENPDIVLGNGSNGRAFVEIKHVESYPNYAVFIDGKRAAQNGQLAHYDVQNDAALMIVLDMEQQVCFERFDWREYNQAALREFETRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM1</accession>
    <name>F9UTM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642958.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3348"/>
    <dbReference type="EnsemblBacteria" id="CCC80339">
        <property type="protein sequence ID" value="CCC80339"/>
        <property type="gene ID" value="lp_3348"/>
    </dbReference>
    <dbReference type="GeneID" id="57026602"/>
    <dbReference type="GeneID" id="66450865"/>
    <dbReference type="KEGG" id="lpl:lp_3348"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2791"/>
    <dbReference type="eggNOG" id="ENOG502ZVY8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174713_0_0_9"/>
    <dbReference type="OMA" id="NFAPQKG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2828-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="12065" checksum="2D3792C1193E7178" modified="2011-10-19" version="1">MLNVFDIVKLTKIDHKEVDSNQVVVTDGNGKPNAILTELLNDVVGNMRIFINMEDVYSVDDLMRALAAHTPLPQDVLEEYEKVLREPIYNINFVPKRGQVEVVIGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN0</accession>
    <name>F9UTN0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein, DUF125 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890862.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3359"/>
    <dbReference type="EnsemblBacteria" id="CCC80348">
        <property type="protein sequence ID" value="CCC80348"/>
        <property type="gene ID" value="lp_3359"/>
    </dbReference>
    <dbReference type="GeneID" id="57026611"/>
    <dbReference type="GeneID" id="66450875"/>
    <dbReference type="KEGG" id="lpl:lp_3359"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2801"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_3_1_9"/>
    <dbReference type="OMA" id="YQFIATI"/>
    <dbReference type="PhylomeDB" id="F9UTN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2837-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="232" mass="25063" checksum="DE5C7D2BC65877E5" modified="2011-10-19" version="1">MQLTRTKSEKTKQTMDEKLNSLRAGVLGSNDGILTVVGVLFSVAAATTNQFTIFIAGLSDLLACAFSMASGEYASVSTQKDTEKAVVEKERQLLKTDFEGELHAVQRHYMTLGVTEETAMAIARDLLTKKPLATVVSIKYDMQLGHYMNPWDAAFASLFSASAGGVFPLLAMTFAPAHWQWPATIIAVSVAVALTGYLSAVLGKGNVKTAVIRNVLVGIVTMFIHYYVGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN8</accession>
    <name>F9UTN8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hpk2</name>
        <name evidence="8" type="ordered locus">lp_0282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643713.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888322.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0282"/>
    <dbReference type="EnsemblBacteria" id="CCC77808">
        <property type="protein sequence ID" value="CCC77808"/>
        <property type="gene ID" value="lp_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0282"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.235"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="OMA" id="NQDAWIL"/>
    <dbReference type="PhylomeDB" id="F9UTN8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-230-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="43"/>
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            <end position="137"/>
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    </feature>
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        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="248"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="458" mass="51538" checksum="EAD5A1C43B3DBDE1" modified="2011-10-19" version="1">MPKNNTTPTYEQLINKAIRRLMLTITLLVSLITLLMVGTQQTINTTREARDLMSSLNQANIKDVPSFIQWNNTTTRNTKQPAFIRVTTKKATLTTATKTKRTIITTPSSKSFFTKQQTKLVGPLVYVRGFGFFLSYSEKDGHNTYQLWVSLRRLFNSLLILILLMLAVTCAALALGTWWAHRLALRLSDPTIKLLHATKYTSNNPDSDQPTLDVPASPREINDLGRAFNELLVTQNQRLQHERQFISDASHELRTPIAAIRGNLSLIKRRGDAHPEVIPESLQFIDEESLRMQHLIENLLHLSRADRAKLVLTDQDLSLLMLSLAEHYQPSIDQPLTLAIDPNIHVQGNAEMLQQIVVALLDNAHKYSPHDQPITLSLHQTDQAVELAVADHGEGIPDDQKQAVFQRFYRVDQSRSQAIEGSGLGLAIVQQLVTLNQANIKITDNQPSGSIFTVSWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP2</accession>
    <name>F9UTP2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts6C</name>
        <name evidence="11" type="ordered locus">lp_0286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888326.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0286"/>
    <dbReference type="EnsemblBacteria" id="CCC77812">
        <property type="protein sequence ID" value="CCC77812"/>
        <property type="gene ID" value="lp_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0286"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.240"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_0_9"/>
    <dbReference type="OMA" id="ASFDIMA"/>
    <dbReference type="PhylomeDB" id="F9UTP2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-234-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00359">
        <property type="entry name" value="cello_pts_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="441" mass="47655" checksum="7055054175328E73" modified="2011-10-19" version="1">MSENNNKSSFVNDRLVPFFGKIAGSRHLIALRDGMTLAVPMIIIGSVFMIIAQFPIKGYQTFMANTFGSNWSTIVQYPTNASFHIMGLIAVIGISYNLAKSYKVDPISASIVSLGAWFLTIPLNTDKAGALWVPLTQLDSAGLFTALLIGLFITDFYVFMVHRNWTIKMPDSVPPAVSNSFAALVPGFVILFLMWLLRLAVEASPMQSIPNVISFVLAKPLGLLSNTLPGALVAEFVVCILWIFGIHGANVVSGVMQPIWLAAMSQNAEALKAGKALPNVVTQQFFDNFVHMGGSGATLGLAFMIAFVAKSAEFKTLGKLVIGPALFNINEPIVFGLPIVMNYRIAVPFILAPLVNVTTTYIAMSTGLVAKTVGVMVPWTTPPIISGYLATMHISGAVLQIVNIVLDGAIYYFFFKALDRDKVKEEKTFAAKEAAGETVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR3</accession>
    <name>F9UTR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646418.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888347.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77833">
        <property type="protein sequence ID" value="CCC77833"/>
        <property type="gene ID" value="lp_0309"/>
    </dbReference>
    <dbReference type="GeneID" id="57027120"/>
    <dbReference type="KEGG" id="lpl:lp_0309"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.262"/>
    <dbReference type="eggNOG" id="ENOG5030A2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2035119_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-255-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="12907" checksum="17A5ADF5F9FBF70B" modified="2011-10-19" version="1">MKKTFTWSVSNGFAVLLLTVGTILAIITLGISFGSPISVDAMVTAAALWLAGVVFLHPAPVRILIPVITLVSLSLGYATYFSTSGSWLLAILATIITAGIISYGFSLRKSIRQHHSHWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW4</accession>
    <name>F9UTW4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine/carnitine/choline ABC transporter, substrate binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">choS</name>
        <name evidence="8" type="ordered locus">lp_0367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643770.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0367"/>
    <dbReference type="EnsemblBacteria" id="CCC77884">
        <property type="protein sequence ID" value="CCC77884"/>
        <property type="gene ID" value="lp_0367"/>
    </dbReference>
    <dbReference type="GeneID" id="57027174"/>
    <dbReference type="KEGG" id="lpl:lp_0367"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.311"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_0_1_9"/>
    <dbReference type="OMA" id="FRSLHEM"/>
    <dbReference type="PhylomeDB" id="F9UTW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-306-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="508" mass="55811" checksum="957837665C9732F1" modified="2011-10-19" version="1">MQTLIQTFIDRRGDLLTALWQHLGISLASLVIAMVIAIPLAIWVVRRPRWAEGLLQLTSVLQTIPSLALLGLLIPLVGIGTVPAVIALVIYALLPIFQNTYLGISEIDASIEEAADAFGMSRMRKLFKVELPIALPQIIAGIRTALVLIIGTATLAALIGAGGLGTFIMLGIDRNDTSLLLIGAISSALLAILLSALVRWFQTAKPRHALIVFVGILALLGGGGAYSVYANRVETITIAGKLGSEPEILINMYKQLIEAEDEHVHVTLKPNFGKTTFLFSALKNNQVDIYPEFTGSVLETLVKGNNPAGQTANQTYQLAKQRLAKQEQMTYLKPMQYNNTYALAVTKKFQQEHHLKTISDLTQVESILKPGMTLEFIDRNDGLKGIKKTYGLDVTAKSMEPALRYEAISKGKINLVDAYATDSELRQYHLALLKDNKHFFPTYQGAPLMKTSFANKHPKVVKALNKLAGKISETDMQEMNYEVNVKKQSASTVAHRYLVKHGLLKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX3</accession>
    <name>F9UTX3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC80385.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890899.1">
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    </dbReference>
    <dbReference type="GeneID" id="57026631"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC80395">
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    <dbReference type="InterPro" id="IPR027994">
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        <property type="entry name" value="WxL"/>
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    </evidence>
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    <accession>F9UUI4</accession>
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            <fullName evidence="5">PTS system glucose-specific EIICBA component</fullName>
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        <name evidence="5" type="primary">pts32A</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102200.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3520"/>
    <dbReference type="EnsemblBacteria" id="CCC80486">
        <property type="protein sequence ID" value="CCC80486"/>
        <property type="gene ID" value="lp_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3520"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2934"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_5_1_9"/>
    <dbReference type="OMA" id="ESEIIHY"/>
    <dbReference type="PhylomeDB" id="F9UUI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2974-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="4">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="160" mass="16958" checksum="3168FD12D5788809" modified="2011-10-19" version="1">MFGFKKKPVSLDLKAIASGKMVPITQVPDEVFAQKMMGDGFAIEPTQGTITAPADGEIKTLADTKHAVMMTTSDGLELLLHLGLDTVELDGKPFDALIKIGDKVKAGTPLVTMDLEAIRAAGKKATVITVVTNMDKVANIEVNSTENVTAMDTVVKITLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>P59399</accession>
    <accession>F9UR75</accession>
    <name>HISX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol dehydrogenase</fullName>
            <shortName evidence="1">HDH</shortName>
            <ecNumber evidence="1">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisD</name>
        <name type="ordered locus">lp_2559</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101827.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59399"/>
    <dbReference type="SMR" id="P59399"/>
    <dbReference type="STRING" id="220668.lp_2559"/>
    <dbReference type="EnsemblBacteria" id="CCC79714">
        <property type="protein sequence ID" value="CCC79714"/>
        <property type="gene ID" value="lp_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2559"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2150"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_9"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="PhylomeDB" id="P59399"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2206-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000135782" description="Histidinol dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <sequence length="428" mass="45986" checksum="9DE9DDE6D8487D2C" modified="2003-03-25" version="1">MKIINEDLASLKRLVQTKTQQLTDLKVESAVREIIANVIKNGDAAVKDYETQFDKVTLTDFKLSQTVIDDAYNNLDPQVKDALLLAKRNITSFHEKEKATGFIDAEQPGVLRGQKLMPLNRVGLYVPGGTAAYPSTLLMSALPAKIAGVNEVIMVTPPQVDGINPAVLAAAKIAGVDAIYQVGGAQAIAALAYGTESIPAVDKIIGPGNIFVATAKKQVFGQVAIDMVAGPSEIGILADDSADPRQLAADLLSQAEHDRRARPILITDSADLAQAVSDNVTSQLKVLPREAIATDAVNEKGFIAVVAKIEEMFDLMNTVAPEHLEVQLKNPTQYLNLIKNAGSVFLGRYASEPLGDYVAGPNHILPTSGTARFSSPLGVYDFVKRTSFIQYTKDALAKEAPAITTLARVEGLEGHARAIESRFDTYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE5</accession>
    <name>Q6LWE5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traE</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222039.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133746.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723582"/>
    <dbReference type="EnsemblBacteria" id="CAG17863">
        <property type="protein sequence ID" value="CAG17863"/>
        <property type="gene ID" value="CAG17863"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17863"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3110"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009097_6_0_9"/>
    <dbReference type="OMA" id="DPENEYT"/>
    <dbReference type="PhylomeDB" id="Q6LWE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3163-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="1">
        <location>
            <begin position="263"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="672" mass="77473" checksum="702E94B3A86DAD56" modified="2004-07-05" version="1">MGFGDKIIDLFMPTKKERQPSNHELAVSEPKPEIEDFTKLIDRDSLHSLFPFSWEQYPTYVQSGENFIRVLAIADYPKRVYGNWLSELKRKKGVIDIVQYIDSASNNSMITYYKKTIQNKEAQKLNTFDPYKKKILQNYINSANMQLDKYLDNSTTFVYQHMLIYLRTNSLAELDDLTENVKNTLIKLQMKPLVPVKATFQAFWSTMPINENLLGDYTYKESNTEVASSMFPFDDAEILDLKPRSDIEGVNKDTNSLIAVDMLDRNKTLNQNQVIIGTSGVGKTTYMIQKILRYAIQDYQLYIIDPENEYTKIVEALGGAVLHLTSNAKYKINPLQIFSEEILSADEAVMNLDLLVKDKIQRLKGFFEVLKTGITQVELAILDDVVKQAYVNSGVLKYSRLKEIKDDQWPTLSNVYDELEKLADRDEDKFNRVKDFYYILGSYTHGSNSLFDGHTNVNLKGKIISFDLKPLQSEQEVQSAAYLNTFQYLWDEITKDRHSRKKLFVDEFHFLTLHKAAATFFHQAYKRFRKYNAGAIAGTQQIQDVIEGTTDTGQNIGEAIIGNSYTKVFFGFDGKGVDDVITKLRMTFSDKEKKLLERRRQGEALMIYGSQRAFMRVELTEEELRLIDPEAYQEKYHRETAGQPDYQKRVVLTPSEIDDLTTTEEEGGALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF2</accession>
    <name>Q6LWF2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf25</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222032.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133739.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723575"/>
    <dbReference type="EnsemblBacteria" id="CAG17856">
        <property type="protein sequence ID" value="CAG17856"/>
        <property type="gene ID" value="CAG17856"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17856"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3103"/>
    <dbReference type="eggNOG" id="ENOG50323VN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158562_0_0_9"/>
    <dbReference type="OMA" id="YKAKAIN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3156-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004277950" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="13999" checksum="2D92B8CB3727F88E" modified="2004-07-05" version="1">MKKYRKYIIAVMTVLLIAVGLTACGKSIAQDLQSNKWYLNQKGQSYKTQFNKKTMIIESPLMNVNATYSVSNTSGKEYLKVDTDDEKNQKFELTQISDGYKAKAINKSAKADNGLGSFELQKRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S52</accession>
    <accession>F9ULE6</accession>
    <name>RHAD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaD</name>
        <name type="ordered locus">lp_3592</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:19689"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="EC" id="4.1.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. RhaD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S52"/>
    <dbReference type="SMR" id="Q88S52"/>
    <dbReference type="STRING" id="220668.lp_3592"/>
    <dbReference type="EnsemblBacteria" id="CCC80553">
        <property type="protein sequence ID" value="CCC80553"/>
        <property type="gene ID" value="lp_3592"/>
    </dbReference>
    <dbReference type="GeneID" id="57026786"/>
    <dbReference type="KEGG" id="lpl:lp_3592"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2997"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076831_0_0_9"/>
    <dbReference type="PhylomeDB" id="Q88S52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3040-MON"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00770">
        <property type="entry name" value="RhaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013447">
        <property type="entry name" value="Rhamnulose-1-P_Aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02624">
        <property type="entry name" value="rhamnu_1P_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000209662" description="Rhamnulose-1-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00770"/>
        </source>
    </evidence>
    <sequence length="283" mass="31938" checksum="E2AED861A6C42896" modified="2011-11-16" version="2">MIMTDFIDSPYVRDMAQTTENLYRHGWDERNGGNVSLRLTKEEVEAYAGTDKVLRQIPIKFDASELAGKYYLVTGTGRYFKNMVEFPERDMGLIRISEVGNSVDLMWGFNDGGEPTSEFPSHLMSHIARLKQDPDQRVIMHCHPTNLVAMTFTIPLSSKRFSRTLWKMHPESIVVFPEGVGVIPYMCPGTNEIGEKTAAKMADYRVVVWPHHGVFAAGDSLDETYGLVETVEKSALIYTTIREQGGEVLQSLTDKDFRDLIKRFDLKANEDFLTPDAVGATVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU8</accession>
    <accession>F9UQQ8</accession>
    <name>YIDD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2358</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101723.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU8"/>
    <dbReference type="STRING" id="220668.lp_2358"/>
    <dbReference type="EnsemblBacteria" id="CCC79547">
        <property type="protein sequence ID" value="CCC79547"/>
        <property type="gene ID" value="lp_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2358"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1992"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_5_2_9"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="PhylomeDB" id="Q88UU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2031-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171833" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="90" mass="10476" checksum="05EA94B813D92B53" modified="2003-06-01" version="1">MRRLLMKGIRFYQRAFSAFSPAHCRYYPTCSNYTLEAINRFGAVKGVLMGVARILRCQPLVKGGFDPVPAHFSLRRNPQYKEEDHRGKKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V55</accession>
    <accession>F9UQF2</accession>
    <name>SPX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Global transcriptional regulator Spx</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spx</name>
        <name type="ordered locus">lp_2228</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the C-terminal domain of the alpha subunit of the RNAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family. Spx subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101690.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889955.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V55"/>
    <dbReference type="SMR" id="Q88V55"/>
    <dbReference type="STRING" id="220668.lp_2228"/>
    <dbReference type="EnsemblBacteria" id="CCC79441">
        <property type="protein sequence ID" value="CCC79441"/>
        <property type="gene ID" value="lp_2228"/>
    </dbReference>
    <dbReference type="GeneID" id="57025751"/>
    <dbReference type="GeneID" id="66449976"/>
    <dbReference type="KEGG" id="lpl:lp_2228"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1883"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_9"/>
    <dbReference type="OMA" id="IMIDDKR"/>
    <dbReference type="PhylomeDB" id="Q88V55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1902-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01132">
        <property type="entry name" value="Spx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023731">
        <property type="entry name" value="Spx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000162556" description="Global transcriptional regulator Spx">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01132"/>
        </source>
    </evidence>
    <sequence length="132" mass="15485" checksum="1C975DEE41341D86" modified="2003-06-01" version="1">MVILYTAPSCTSCRKAKAWLQTHDIDFQEHNLFTEPLSIEKIKQILQLTESGTEEIISTRSKAFQQLNVDINDLSLNELFDMITHDPSLLRRPIMLDEKRLQVGYNEDEIRRFLPRKIRTLELLRAQQLANM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V56</accession>
    <accession>F9UQF1</accession>
    <name>MECA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adapter protein MecA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mecA</name>
        <name type="ordered locus">lp_2227</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V56"/>
    <dbReference type="SMR" id="Q88V56"/>
    <dbReference type="STRING" id="220668.lp_2227"/>
    <dbReference type="EnsemblBacteria" id="CCC79440">
        <property type="protein sequence ID" value="CCC79440"/>
        <property type="gene ID" value="lp_2227"/>
    </dbReference>
    <dbReference type="GeneID" id="57025750"/>
    <dbReference type="KEGG" id="lpl:lp_2227"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1882"/>
    <dbReference type="eggNOG" id="COG4862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071496_2_0_9"/>
    <dbReference type="OMA" id="EFFYTVM"/>
    <dbReference type="PhylomeDB" id="Q88V56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1901-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01124">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038471">
        <property type="entry name" value="MecA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008681">
        <property type="entry name" value="Neg-reg_MecA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39161">
        <property type="entry name" value="PTHR39161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05389">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029008">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212271" description="Adapter protein MecA">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="243" mass="27807" checksum="F654D66F731050AE" modified="2003-06-01" version="1">MEMERINEDTIRVVIGNDDLNERGIRVLDLLGNHKQIESFFYSILEEVDVDHQFQDNDAVTFQVLPNRNGLELFISKNSDNLQDTIAKATQSPDQSDDSDSQDDVSDYLKRKLMQTDTNQVEDGQGIAHNPTKDTNDLDPYLDDPDTPTKEYVLKFDQFEDLVSLAQLFRPEGLASNLFKYRDQYYLELVFFVDQSSTATIKDDVAVALEYAHLANISADVLLEHGEKIMSNAALETIRHYFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V76</accession>
    <accession>F9UQD1</accession>
    <name>RSMH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">lp_2202</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889934.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V76"/>
    <dbReference type="SMR" id="Q88V76"/>
    <dbReference type="STRING" id="220668.lp_2202"/>
    <dbReference type="EnsemblBacteria" id="CCC79420">
        <property type="protein sequence ID" value="CCC79420"/>
        <property type="gene ID" value="lp_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2202"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1861"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_9"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="PhylomeDB" id="Q88V76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1881-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108644" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="319" mass="35782" checksum="B333F69A4658B449" modified="2003-06-01" version="1">MATFEHTTVLLHEAIAALNVRPDGIYVDCTLGGGGHSREILQQLGLEGHLYSFDQDQTAIDYNQSNLATYLERGQVTFIKSNFANLKTELNARGLDHVDGVVYDLGVSSPQFDDAARGFSYQHDAPLDMRMDQSQKLTAQTVVNTWPYADLVRIFYRYGEEKFSKQVARLIERERAVQPIVTTGQLVEIIKNAIPARARRTGGHPAKRVFQAIRIAVNNELGVLETSLEQAIDLINVHGRVSVITFQSLEDRLVKTIFKEHSDLPELPPGLPVIPAEMQPDYRLVSRKPVVPSDAEIEANRRARSAKLRAIERLKITNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VS0</accession>
    <accession>F9UPT2</accession>
    <name>ERA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">lp_1967</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889735.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VS0"/>
    <dbReference type="SMR" id="Q88VS0"/>
    <dbReference type="STRING" id="220668.lp_1967"/>
    <dbReference type="EnsemblBacteria" id="CCC79221">
        <property type="protein sequence ID" value="CCC79221"/>
        <property type="gene ID" value="lp_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1967"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1661"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_9"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="PhylomeDB" id="Q88VS0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1685-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000180022" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <sequence length="302" mass="34284" checksum="4D6CCE95C2AEC6BC" modified="2003-06-01" version="1">MAEQQAFHSGFVAIIGRPNVGKSTLLNRVVGQKVAIMSDKAQTTRNRIQGIYTTADTQMVFIDTPGIHKPHSRLGDFMVKSALSTLGEVDAVLFMINADERRGAGDNFIIDRLKTVKQPIYLVINKIDQVHPDHLLEIMDQYKDALPWKEVYPISALEGNNVDELLTTLKGQLPEGPQYYPSDQITDHPERFIISELIREKVLELTRQEVPHSTAVVIDSIKRQDEEKIHVQATIIIERSSQKGIIIGKGGSMLKKIGSLARRDIEHLLGDKVYLELWVKVQENWKDRQDLLASYGYRQDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W73</accession>
    <name>Q88W73_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrAA2</name>
        <name evidence="2" type="synonym">carA</name>
        <name evidence="4" type="ordered locus">lp_1783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101548.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889584.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q88W73"/>
    <dbReference type="STRING" id="220668.lp_1783"/>
    <dbReference type="EnsemblBacteria" id="CCC79070">
        <property type="protein sequence ID" value="CCC79070"/>
        <property type="gene ID" value="lp_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1783"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1504"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_1_9"/>
    <dbReference type="OMA" id="IIFHTAM"/>
    <dbReference type="PhylomeDB" id="Q88W73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1533-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="360" mass="39227" checksum="768C1E9828FA6A98" modified="2003-06-01" version="1">MADRYLILEDGSAYLGEGFGSPAVSTGEIVVNTSMTGYQEIITNQIYHNQIVAFTQPTIGSYGINHDSYESILPTVKGVVVRDVASISTNRQRRWSLDQYLKQQNIPGISHIDTRHLAKQLRASGPMKASIVDVADAHAFDQLGATVLTNQQVAAVATPKPFPNPGTGLNVVVIDFGLKHGILRELSKRACNVTVLPYTATTEEILNLDPDGVILSTGPGKPQDLPVSVTEMIKNIQNRVPLFAIGLGHELFAMANGAQIMKLSPEHHGANHPIREVITNQIIYAAQGQGFAVDADTVDRNKLITTFVDLIDGTIQGLRLRDFPAFSVQFFPDGAPGPTETRDIFDEFVESMQQARGPIW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ2</accession>
    <accession>F9UP11</accession>
    <name>TRMD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">lp_1639</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640384.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889464.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ2"/>
    <dbReference type="SMR" id="Q88WJ2"/>
    <dbReference type="STRING" id="220668.lp_1639"/>
    <dbReference type="EnsemblBacteria" id="CCC78950">
        <property type="protein sequence ID" value="CCC78950"/>
        <property type="gene ID" value="lp_1639"/>
    </dbReference>
    <dbReference type="GeneID" id="57025221"/>
    <dbReference type="GeneID" id="66449520"/>
    <dbReference type="KEGG" id="lpl:lp_1639"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1386"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_9"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="PhylomeDB" id="Q88WJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1413-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060393" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="246" mass="27138" checksum="184572A680136DB1" modified="2003-06-01" version="1">MQIDILSLFPEMFAGPLHESMIGNAIENDVINVDVTNFRDFTTDKHNHVDDYPYGGGAGMLLQPQPIFDALASVQEKHPAPGRVILLDPAGVQFNQHVAEDFAQEEHLTFICGHYEGYDERIRSLVTDEVSLGDYVLTGGELGAMVMIDATVRLLPGVLGNSESAPGDSFSSGLLEYPQYTRPADFRGMKVPDILLSGDHGKIDDWRLEQALKRTYERRPDMLTGLSLSGKAKQMLADIKADESEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WK0</accession>
    <accession>F9UP03</accession>
    <name>RNC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">lp_1631</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640377.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889456.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WK0"/>
    <dbReference type="SMR" id="Q88WK0"/>
    <dbReference type="STRING" id="220668.lp_1631"/>
    <dbReference type="EnsemblBacteria" id="CCC78942">
        <property type="protein sequence ID" value="CCC78942"/>
        <property type="gene ID" value="lp_1631"/>
    </dbReference>
    <dbReference type="GeneID" id="57025213"/>
    <dbReference type="GeneID" id="66449512"/>
    <dbReference type="KEGG" id="lpl:lp_1631"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1378"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_9"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="PhylomeDB" id="Q88WK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1405-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000180404" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="161"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="231" mass="26652" checksum="A152A49953CBFB12" modified="2003-06-01" version="1">MITELAAMLKERFGIVFNDPDLLAEAFTQASYVNEHQDQQLKYYERVEFLGDAVLELVVSEYLYKRYKDMPQGKLTRLRAAMVCEESFASFARECDFPQYIRLGKGEQKAHAWERDSLLCDIFESFVGALYLDQGREPVLKFVHQVIFPKLDEGRFDGVFDYKTTLQEYLQRDGDVAIDYQLIEQDGPANERSYEIAVLADGQKIGEGWGHSKKEAEQSAARQAYSQLQQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X53</accession>
    <accession>F9UNE5</accession>
    <name>SYR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">lp_1391</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101383.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X53"/>
    <dbReference type="SMR" id="Q88X53"/>
    <dbReference type="STRING" id="220668.lp_1391"/>
    <dbReference type="EnsemblBacteria" id="CCC78734">
        <property type="protein sequence ID" value="CCC78734"/>
        <property type="gene ID" value="lp_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1391"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1165"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_9"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="PhylomeDB" id="Q88X53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1196-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151568" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <sequence length="562" mass="62910" checksum="D3B1F7AF5B6682C2" modified="2003-06-01" version="1">MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDIVEKVDSSDFEKVVAMGPYVNFFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSSPNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGDWGTQFGKLITAYKMWGSEAEVKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFKKIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKSDGATLYITRDLAAAIYRKRTYDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIPFGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKNPDLPNKDEVADAVGIGAVVFHDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAAWDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALVKSVSIVLKEALRLLGVKAPDEM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XV2</accession>
    <accession>F9UMP0</accession>
    <name>ECFA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Energy-coupling factor transporter ATP-binding protein EcfA1</fullName>
            <shortName evidence="1">ECF transporter A component EcfA1</shortName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ecfA1</name>
        <name type="synonym">cbiO1</name>
        <name type="ordered locus">lp_1073</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888993.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XV2"/>
    <dbReference type="SMR" id="Q88XV2"/>
    <dbReference type="STRING" id="220668.lp_1073"/>
    <dbReference type="EnsemblBacteria" id="CCC78479">
        <property type="protein sequence ID" value="CCC78479"/>
        <property type="gene ID" value="lp_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1073"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.908"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="PhylomeDB" id="Q88XV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-922-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51246">
        <property type="entry name" value="CBIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092021" description="Energy-coupling factor transporter ATP-binding protein EcfA1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01710"/>
        </source>
    </evidence>
    <sequence length="281" mass="30856" checksum="96F7ADAF440FF764" modified="2003-06-01" version="1">MVSPIIDVKHLDYRYPQQATDQLTLHDISFTVMPGEWVAIVGHNGSGKSTLAKNLNGLLAPAAGTITVDGQVLSEETVWDIRRKIGMVFQNPDNQFVGATVADDVAFSLENQGVPRSEMLTRVQAALEQVNMQDFATREPARLSGGQKQRVALAGMIAARPQILILDEATSMLDPRGRQEVLTTIRDMKANSALTVLSITHDIDEAASANRVLVINDGEVKEEGTPAEIFQHGEALIKMGLDMPYAERLKAALKRQGVQVPAQYLTEKGMADWLWQLRSNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XZ6</accession>
    <accession>F9UMJ5</accession>
    <name>CTSR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator CtsR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class three stress gene repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ctsR</name>
        <name type="ordered locus">lp_1018</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="1688" last="1694">
            <title>The Lactobacillus plantarum ftsH gene is a novel member of the CtsR stress response regulon.</title>
            <authorList>
                <person name="Fiocco D."/>
                <person name="Collins M."/>
                <person name="Muscariello L."/>
                <person name="Hols P."/>
                <person name="Kleerebezem M."/>
                <person name="Msadek T."/>
                <person name="Spano G."/>
            </authorList>
            <dbReference type="PubMed" id="19074391"/>
            <dbReference type="DOI" id="10.1128/JB.01551-08"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the ftsH promoter region, leading to repression of its expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Disruption leads to increased expression of ftsH, indicating CtsR is a transcriptional repressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CtsR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888948.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XZ6"/>
    <dbReference type="SMR" id="Q88XZ6"/>
    <dbReference type="STRING" id="220668.lp_1018"/>
    <dbReference type="EnsemblBacteria" id="CCC78434">
        <property type="protein sequence ID" value="CCC78434"/>
        <property type="gene ID" value="lp_1018"/>
    </dbReference>
    <dbReference type="GeneID" id="57024681"/>
    <dbReference type="GeneID" id="66448935"/>
    <dbReference type="KEGG" id="lpl:lp_1018"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.860"/>
    <dbReference type="eggNOG" id="COG4463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118139_0_0_9"/>
    <dbReference type="OMA" id="FRCAPSQ"/>
    <dbReference type="PhylomeDB" id="Q88XZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-877-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010607">
        <property type="entry name" value="Txn_repr_CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000400425" description="Transcriptional regulator CtsR">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="19074391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="155" mass="17614" checksum="684CCB3D0D9BCDA6" modified="2003-06-01" version="1">MQSQNISDIIEKYLKSILADSEHVEIRRSEIADLFNVVPSQINYVIKTRFTIQNGYLVESKRGGGGYIRIEKVNLVDDADVLDALIQVIGDSITQRDAYAVVQSLYEDDVLNRREAQLILVAIDHETLGLTDRDLENSLRARIIIGILNHLRYES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y39</accession>
    <accession>F9UMF2</accession>
    <name>ASNA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnA</name>
        <name type="ordered locus">lp_0957</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y39"/>
    <dbReference type="SMR" id="Q88Y39"/>
    <dbReference type="STRING" id="220668.lp_0957"/>
    <dbReference type="EnsemblBacteria" id="CCC78391">
        <property type="protein sequence ID" value="CCC78391"/>
        <property type="gene ID" value="lp_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0957"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.814"/>
    <dbReference type="eggNOG" id="COG2502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071543_0_0_9"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="PhylomeDB" id="Q88Y39"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-827-MON"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195881" description="Aspartate--ammonia ligase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <sequence length="322" mass="37552" checksum="2257E483E7862461" modified="2003-06-01" version="1">MHLIIPKDYDPKLSVKETQQAIRYIRETFQDEFGKQLNLSRLSAPMFVEKKTGLNDNLNGVEKPVSFTMQDMGDEQIEIVHSLAKWKRVALKRYGFDMHEGLYTNMNAIRKDEDLDNYHSAYVDQWDWEKVISKEERTVETLKAAVRQIFKVIKHMEHEVWYKFPQAVHHLPDEIHFLTTQELEDMYPDMTPRERENAICKKLGCVFLMQIGWKLDSGERHDGRAPDYDDWKLNGDILFWYEPLDQAIEISSMGIRVDAESMKKQLKDVDAEDRLSLPYHQMILNADVPYTIGGGIGQSRLCMLLLGKAHVGEVQAALWHKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YK1</accession>
    <accession>F9ULY3</accession>
    <name>GPDA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">lp_0756</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YK1"/>
    <dbReference type="SMR" id="Q88YK1"/>
    <dbReference type="STRING" id="220668.lp_0756"/>
    <dbReference type="EnsemblBacteria" id="CCC78222">
        <property type="protein sequence ID" value="CCC78222"/>
        <property type="gene ID" value="lp_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0756"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.637"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_9"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="PhylomeDB" id="Q88YK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-657-MON"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137977" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="338" mass="36579" checksum="2AA400CAC2F8A353" modified="2003-06-01" version="1">MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETLTAYSNLTQAIDGADVILFVVPTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRLSQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAASADESAAELVQQLFMNDYFRIYTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLTFIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQQNIEMPITEAIYDVLYKSADIKEVIPQLMRREGKPEIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z44</accession>
    <accession>F9UKZ7</accession>
    <name>ACPS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">lp_0522</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888526.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z44"/>
    <dbReference type="SMR" id="Q88Z44"/>
    <dbReference type="STRING" id="220668.lp_0522"/>
    <dbReference type="EnsemblBacteria" id="CCC78012">
        <property type="protein sequence ID" value="CCC78012"/>
        <property type="gene ID" value="lp_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="57024293"/>
    <dbReference type="KEGG" id="lpl:lp_0522"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.430"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_1_2_9"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="PhylomeDB" id="Q88Z44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-433-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175658" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="120" mass="13193" checksum="63492864F031BBA2" modified="2003-06-01" version="1">MIYGTGIDLTELSRIEAILAKGLRLPEKILTPAELAVFSRYPVKRQIEFMAGRFSAKEAYSKAYGTGIGAAVGFQDIEILDNAQGKPEVTRHPFDGPAWISISHTDTLVMTQVILERGNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZT8</accession>
    <accession>F9UT18</accession>
    <name>CRCB1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB1</name>
        <name type="ordered locus">lp_0213</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641805.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZT8"/>
    <dbReference type="SMR" id="Q88ZT8"/>
    <dbReference type="STRING" id="220668.lp_0213"/>
    <dbReference type="EnsemblBacteria" id="CCC77749">
        <property type="protein sequence ID" value="CCC77749"/>
        <property type="gene ID" value="lp_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="57027037"/>
    <dbReference type="KEGG" id="lpl:lp_0213"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.176"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_3_9"/>
    <dbReference type="OMA" id="EVMDKDH"/>
    <dbReference type="PhylomeDB" id="Q88ZT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-171-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000110116" description="Putative fluoride ion transporter CrcB 1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="116" mass="12497" checksum="0E03D909DE98AEB1" modified="2003-06-01" version="1">MLVLVGLAGAGAAVGALSRYGIMRLALPLNRWPLPIATLFINLTGALLLGWILTSSLPPNWQIFLGTGIMGGYTTFSTMINELVLLGRNHHQRVAWEYFGLSLVGGLVMVYLGTLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q890D8</accession>
    <accession>F9USR8</accession>
    <name>PIP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline iminopeptidase</fullName>
            <shortName evidence="2">PIP</shortName>
            <ecNumber>3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Prolyl aminopeptidase</fullName>
            <shortName evidence="2">PAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pip</name>
        <name type="synonym">pepI</name>
        <name type="ordered locus">lp_0088</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Releases the N-terminal proline from various substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888163.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890D8"/>
    <dbReference type="SMR" id="Q890D8"/>
    <dbReference type="STRING" id="220668.lp_0088"/>
    <dbReference type="ESTHER" id="lacpl-PEPI">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.021"/>
    <dbReference type="EnsemblBacteria" id="CCC77649">
        <property type="protein sequence ID" value="CCC77649"/>
        <property type="gene ID" value="lp_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0088"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.72"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_1_9"/>
    <dbReference type="PhylomeDB" id="Q890D8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-71-MON"/>
    <dbReference type="BRENDA" id="3.4.11.5">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031975">
        <property type="term" value="C:envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000406326" description="Proline iminopeptidase">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P52278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <sequence length="287" mass="32411" checksum="7A809B182D7D1D3B" modified="2011-11-16" version="2">MPFNGYQTYYRIVGDRQSNKTPLVLLHGGPGSTHNYFEGFDDLAAQTGRPIVMYDQLGCGRSSIPDDDQLWQAAMWVAELRALRTYLDLPEIHLLGQSWGGMLAIIYGCDYRPQGIKSLILASTLSSARLWAQEQHRMIRLMSPVDQSAIATAERLQDFTGAAYLTANQHFMTQHASGPITADDPEFLRRSKRVGTTAYNVAWGPNEYNPTGTLADYEYTDRLQYLQMPTLVTSGTDDLCTPLVAKTMVDQLPHATWTLFPRSRHMAFIDENTAYMTRLRHWLAAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX1</accession>
    <name>F9UKX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, thiamine diphosphate binding domain</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tkt1A</name>
        <name evidence="2" type="ordered locus">lp_0489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0489"/>
    <dbReference type="EnsemblBacteria" id="CCC77986">
        <property type="protein sequence ID" value="CCC77986"/>
        <property type="gene ID" value="lp_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0489"/>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_9"/>
    <dbReference type="OMA" id="GDHPDRT"/>
    <dbReference type="PhylomeDB" id="F9UKX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-407-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="275" mass="30253" checksum="2AA441B4025BE9A5" modified="2011-10-19" version="1">MTNKQLSVTQQRKLLLDSFKIREEIIDIAATLTGCHIGGSLSITDLLNYSLELYGNNPLNEVILSKGHAAAALYAALFTKGILKEKPSLSYGIKGSLLLGHPNNELPGIPYSTGSLGHGIGYGAGWALGQRLKQKEGIAVVLGGDGELQEGSVWEALQVISSKQIHNLIYIIDRNQAQNDGFLDNISEYYDLSARFKSFGFQVVEIDGHNFNNIHSAFQNKSANKALVIIADTVKGKGIRLMEGNPKSHYAKISVSQADKWKKQIKYQYEKNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX4</accession>
    <name>F9UKX4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888503.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0492"/>
    <dbReference type="EnsemblBacteria" id="CCC77989">
        <property type="protein sequence ID" value="CCC77989"/>
        <property type="gene ID" value="lp_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0492"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.406"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_9_0_9"/>
    <dbReference type="OMA" id="EGIHFMK"/>
    <dbReference type="PhylomeDB" id="F9UKX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-410-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="403" mass="44031" checksum="3350F6ED2760BD91" modified="2011-10-19" version="1">MNITSLLGRREFRNFFLADIISGFGVGLTTVGANWYMLQSTHSNKLVGMYLTVNVLAGFLMSPLAGSLTDRFSRKQVILWTFLGRALPMSLIALVIGYSGFNLWAMYGLAILTGAGWITYMAASRSYVQAVLPEELLGTANSFIEVSLQVGMFAAGAISGIILNYTGFMIILVINIIMFFVAVLLVAAIKADSPVNKGINEESAGFSNGLEYIWKHKSILSMGIISILPLIVTQLFNVSSPDYVSTVLRANSVVYGFVDMGYGIGGLAAGLITGYLINHFKNKNIIVFFFTLATIGLLTLYWTHVIPLTYVCTFSLGLSNSALRVVINTVLMHRVDKKFMGRATSIWNGTAQLIEVFASTLMGVANDKFGANIGFLWMAVIMLIGAVWSFIMLNTTKLRSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL93</accession>
    <name>F9UL93_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Prophage P1 protein 7</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888622.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0630"/>
    <dbReference type="DNASU" id="1061745"/>
    <dbReference type="EnsemblBacteria" id="CCC78108">
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        <property type="gene ID" value="lp_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0630"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122894_3_0_9"/>
    <dbReference type="OMA" id="HANLAGY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-541-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="138" mass="15950" checksum="0F32BBE8B03FF27F" modified="2011-10-19" version="1">MDRVKDIVKAIVNRYHTADPFVIAEKLNIQVEWCDFWAMPLGKNAYDNKEPIILLNNSIKHTPTQYFILGHELGHVIFHEGLIGYYTSVKHGHSKFEREADEFSVGLMGMLFIEENGHIPYSYRELAHQYGVPSDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD3</accession>
    <name>F9ULD3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catalase</fullName>
            <ecNumber evidence="10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kat</name>
        <name evidence="13" type="ordered locus">lp_3578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102230.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891054.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3578"/>
    <dbReference type="EnsemblBacteria" id="CCC80540">
        <property type="protein sequence ID" value="CCC80540"/>
        <property type="gene ID" value="lp_3578"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3578"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2985"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_9"/>
    <dbReference type="OMA" id="WTCYVQV"/>
    <dbReference type="PhylomeDB" id="F9ULD3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3027-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="55329" checksum="D9BF9E341477BB16" modified="2011-10-19" version="1">MTEKLTTETGQPWANNEHSQTAGARGPVLMQDYNLLEKLAHFDRERIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKKTPVILRFSQVAGEKGYPDTVRDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFIHSQKRDPKTNRRTQNMQWDFWAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVNQNGEQFWVKYHFISDQGVKNMTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQILPYEEGLNYKWDIFDVTKVISHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPGIEPSPDKLLQGRLFSYKDAQRYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVNYEPNALHGPEEVPDAAFSPDSVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINTIKDALGQVTLPGVKELEIKQFYEADKNYGTRVANALGMNIADIISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF3</accession>
    <name>F9ULF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, galactitol-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts36A</name>
        <name evidence="2" type="ordered locus">lp_3599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3599"/>
    <dbReference type="EnsemblBacteria" id="CCC80560">
        <property type="protein sequence ID" value="CCC80560"/>
        <property type="gene ID" value="lp_3599"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3599"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3004"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_6_0_9"/>
    <dbReference type="OMA" id="FECTSKI"/>
    <dbReference type="PhylomeDB" id="F9ULF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3047-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="17628" checksum="343035DF7C06DF93" modified="2011-10-19" version="1">MNYQDMLKSDLIFLDVDAESRTDLYKQIAKKLNTRGYVKSSYEAALNKREDEFPTGIVSDYISIALPHADPENINSPFVCVVTTKAPIQMLQMGYNTEEQASTFFFLGITKSDDQLILLQKFMALIQDKDFTTQFSQITDTKEMFNYLSEKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI9</accession>
    <name>F9ULI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan 1,6-alpha-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dexB</name>
        <name evidence="4" type="ordered locus">lp_3641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.70" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891110.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3641"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80596">
        <property type="protein sequence ID" value="CCC80596"/>
        <property type="gene ID" value="lp_3641"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3641"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3040"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="OMA" id="RDWYWWR"/>
    <dbReference type="PhylomeDB" id="F9ULI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3083-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043896">
        <property type="term" value="F:glucan 1,6-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="13"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="541" mass="61837" checksum="55B316340ED3FAA6" modified="2011-10-19" version="1">MQAHWWQRATVYQIYPRSFQDSNGDGIGDIPGIISRLDYLATLGVDALWLSPVYKSPNTDNGYDIADYQAIDPAYGTMADMDQLIAQAAQRGIKIVMDLVVNHTSDEHLWFVDACQNPDSPTRDYYVWADAVDGHAPNDLTSGFSGGSAWELDELTGQYFLHLFSKKQIDLNWQNPDLRRAIYRMMNFWIDKGIEGFRMDVIDMIAKEPRAKILVNGPHLHEYLHEMNRQTWRNRDFLTVGEAWSASPEDARQYSDEQREELSMVFQFGHLWADRQVGGEKWEQRPLDVAQLKQALYACQTTMATHGWNSLFWSNHDLPRAVSRFGATGQYRELSAKMLAIALHGLKGTPFVYQGEEIGMTDCPVATIDQVNDVEARTIYRQLRAQGDDAGTAMQKINIFNRDNARTPMQWTAKQHAGFTTGKPWLAINANYPRINVAAAQADYQSIWWTYQRLIRLRKQSAVLQQGEFTELSAVPAPIVAYTRTWQQTQWLICANFADTLITVDLPKRASELIISNYQDYPEQLGRVVLRPYEAFILALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ0</accession>
    <name>F9ULJ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, substrate binding protein,mannose-related oligosaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3642"/>
    <dbReference type="EnsemblBacteria" id="CCC80597">
        <property type="protein sequence ID" value="CCC80597"/>
        <property type="gene ID" value="lp_3642"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3642"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3041"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="OMA" id="TKLMPKY"/>
    <dbReference type="PhylomeDB" id="F9ULJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3084-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388806" evidence="1">
        <location>
            <begin position="33"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="356"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="490" mass="54101" checksum="7F865886020DE64F" modified="2011-10-19" version="1">MNKFVKGAALVSAVAFGTVALAGCGKSNSDSASSKATTVNMYMPGDKPKNYDAMIKRANKEIHKTYKNINLKMNFIGWGDYEQKYNVMVTSGSGYDLAFAQNYTSNALKGAYADMNSELKSGGVANKAYKQVDSAYWKGLKVNGKTYGFPVNANIYAQNMLTFNDEFLKKYNISINDVDSYASMESALAKFHKEKPGVAAFAIGQGFKASPKHMDFPLGNGLPFAIDSSGSSKKIVNVYDTSEMQGILKTLHSYYQKGYIPKDAATSSTQYNLQDNTWFVRQETQGPFDYGDSALITNAGGKKMKSKAITDPYKSSAQSQVAVWTISKTSKHKKEAMQVLNLLNTDKTLLNNITWGLEGTQWNFTDKAKGKIKITNKYKPNTFIGAWMMGNNKNLYTQDSTTEAMIKKRDQSIKDAKTSAALGFNPDTSSLKTEITNLSNVMSKYLDILNTGTADPVPTIKKMDKELKAAGYDKVQKELQKQYDAFLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ3</accession>
    <name>F9ULJ3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcnA</name>
        <name evidence="7" type="ordered locus">lp_3645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3645"/>
    <dbReference type="CAZy" id="GH20">
        <property type="family name" value="Glycoside Hydrolase Family 20"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80600">
        <property type="protein sequence ID" value="CCC80600"/>
        <property type="gene ID" value="lp_3645"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3645"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3044"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028877_0_0_9"/>
    <dbReference type="OMA" id="IGFTPNN"/>
    <dbReference type="PhylomeDB" id="F9ULJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3087-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="87"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_H_20C_C" evidence="6">
        <location>
            <begin position="417"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="616" mass="69713" checksum="7A64EE8401C51D2E" modified="2011-10-19" version="1">MITWQGLTTEQVQSVQAVCAAIMPTSDLSVECQHATTGIHIQRNGDQARLTYGSMAELMHGAALLCGRARKATQFDIRQQPRFEVLAAMLDVARNGVPTVAMIKQIIRRLASMGYNELWLYLEDLFEIPEAPYFGRGRGRYQQTELHEIALYGDRFGVTIVPAVQTLAHLHNALKWDAHAAVKDTDDTLLVGAPATKDFLTNLLRAASAPFTTNKIHVGMDEAYQLGRGRYLDQNGFTDQETLILQQLQLVVSLTQKLGLKAYMWSDLWFTFASSKHEMYDPDVHFDPAFKASLPPVGQVYWDYYHEDEQTYRERFTQHFELSDDVAFAGGIWTWSALAPNQSKMLATIDAGLKAAKASGVQQVVATMWFDDGAEVPFSAAWYGLQAFATYQYYEDVTPAMIDTEYAMIQGENATFYRLLDQFDNFTSKVNVDADNVSKLILYEDLMLQRYRSNLAVIDVEAHYLDLMTKLDQVHVHQENQLMVTFYKQLARTVLVKQRALKVVVALADSDVTKLRADSARAAVTSCQHALEQLLRDFRALWQQQRRGNGFEVIDVRLGGQIARCETVTWRIDEWLAGRDDLAELREPLLPMDKRNNGLVGHGLYKEIVSACELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ6</accession>
    <name>F9ULJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3648"/>
    <dbReference type="EnsemblBacteria" id="CCC80603">
        <property type="protein sequence ID" value="CCC80603"/>
        <property type="gene ID" value="lp_3648"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3648"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3047"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="PhylomeDB" id="F9ULJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3090-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="38"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="596" mass="67245" checksum="EBB5C7F1CAFDB9EF" modified="2011-10-19" version="1">MTKRNTYNEDEELTSRFNWHDYARLGHYLRPYSWRLCFVLITILIGNIAIILGPYLMKIAIDTAIPNRNLPLIWALSGTFLISLVIAFLCFRYRIWAITEIGQSLLIDMRTDLFTHLQELPFAYFDSRPHGKILIRVVNYINTLSDLLANGLVNLISDIISVLVTLIFMFAINWQLTLDSLALIPVLVLWAYLIQKKQRQAFRKLSDKQSNLNAYIHESIAGIKVTQGFAQEANAIQTFDAVADDNRRAYMQAVKIQYALGPGVQNISTITTALIYFIGIQQLGVVVSTGTLIAFLGYINNFWNPVINIGNFYNSLITATAYLERIFETMDEKPQILDAPDAFNLPPIKGDVRFNNVSFRYEEASPLTLHDISFHAQAGQTIALVGPTGAGKTTIINLLSRFYNVTTGNITIDNINLQQVTLDSLRQQMGVMQQETFIFSGTIMDNIRYGRLDATDDEVRSAAKIARADAFIQTLPSGYNTTVQEHGSSLSAGQRQLLAFARVLLADPRILILDEATAAIDTKTETLLQEGLNELLKGRTSFIVAHRLSTIQRADQILVINHGRIVEAGRHDQLMAMHGEYYRLYDSQYQMLQDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ8</accession>
    <name>F9ULQ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 47, major tail protein 2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101120.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888661.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0670"/>
    <dbReference type="DNASU" id="1061999"/>
    <dbReference type="EnsemblBacteria" id="CCC78147">
        <property type="protein sequence ID" value="CCC78147"/>
        <property type="gene ID" value="lp_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0670"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.562"/>
    <dbReference type="eggNOG" id="ENOG5030A38">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452738_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-581-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="21265" checksum="F58397765E7797F1" modified="2011-10-19" version="1">MAGVKLQTKNADKILYGIKFPWDDKAAQIQMLGLQATSSTTNTRASSAIKLKQGVVHTSGSRTETFVVDSYWIIGDKIHEGLKKVVEKDVAVGIWRMDFNEAKLDANGNVKSVPAEFGMAKPNGLPETEAVNNLLHANITYNIDGNTQDGVLDVSEIDPQLLVDGLKMFDFAHNTDIGTSSKIDNDNSIKPQFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM03</accession>
    <name>F9UM03_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2007-03" db="PDB data bank">
            <title>Crystal structure of Q88YI3_LACPL from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Benach J."/>
                <person name="Chen Y."/>
                <person name="Seetharaman J."/>
                <person name="Chi K.H."/>
                <person name="Janjua H."/>
                <person name="Cunningham K."/>
                <person name="Ma L.C."/>
                <person name="Xiao R."/>
                <person name="Liu J."/>
                <person name="Baran M.C."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888756.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2P0Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=1-333"/>
    </dbReference>
    <dbReference type="PDBsum" id="2P0Y"/>
    <dbReference type="SMR" id="F9UM03"/>
    <dbReference type="STRING" id="220668.lp_0780"/>
    <dbReference type="EnsemblBacteria" id="CCC78242">
        <property type="protein sequence ID" value="CCC78242"/>
        <property type="gene ID" value="lp_0780"/>
    </dbReference>
    <dbReference type="GeneID" id="57024483"/>
    <dbReference type="KEGG" id="lpl:lp_0780"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.659"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_9"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="PhylomeDB" id="F9UM03"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-677-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2P0Y"/>
        </source>
    </evidence>
    <sequence length="333" mass="36605" checksum="1B3FF9242A7B194C" modified="2011-10-19" version="1">MRKYTFKTQRPKIVVIGGGTGLPVVLNGLRKQAVDITAVVTVADDGGSSGIIRNYVNVVPPGDIRNVMVALSSWPDLYKDIFQYRFQGDDQFFAGHAIGNLIIAALTEMKSGVFDAVQELSNMMQVDGHVYPAANEALTLHGKFSDGTELVGEAEITAAHKSLERVWVTDKNGKEPQAVQPVIDAIMAADQIVLGPGSLFTSILPNLTIGNIGRAVCESDAEVVYICNIMTQKGETDNFSDADHVRVLNRHLGQNFINTVLVNTEKVPEDYMDFHKFNEVSKQVSHDFRGLREQNCRVISSNFLKLRDNGAFHDGDQVVAELMNLVGHSDVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM14</accession>
    <name>F9UM14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_0792a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78253.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="lpl:lp_0792a"/>
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    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    <sequence length="82" mass="9558" checksum="06066CDFF75B4EA4" modified="2011-10-19" version="1">MDDFQQQINEWSDWQGLQLNAGAFEPVIQKIYASENEPYKTPEPVRISWPPALRSDPPKSRFFHPVRLSPKLGPIIRRNVLD</sequence>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888785.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0813"/>
    <dbReference type="EnsemblBacteria" id="CCC78271">
        <property type="protein sequence ID" value="CCC78271"/>
        <property type="gene ID" value="lp_0813"/>
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    <dbReference type="KEGG" id="lpl:lp_0813"/>
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    <dbReference type="eggNOG" id="COG0673">
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    <dbReference type="OMA" id="HPRELIL"/>
    <dbReference type="PhylomeDB" id="F9UM32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-707-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
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        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF01408"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="300" mass="32814" checksum="D6D6D52EEE17FE0C" modified="2011-10-19" version="1">MLKIGVIGLGNIAQKAYLPVMAAMQDQYEFHLTTRNPEKRAQLATMYGFQHTHATLEELMAVKPAAVFVHTPTDTHAAIIKQLLLAGIHVYVDKPVATDLQVVQSLYDLAAARHLLLTCGFNRRFAPFNQQLKALPDKRMLVAEKVREVGSQDPETAVFDLMIHMVDTGLFLLDEPLEHTSGRLTTTATGALAQGYLTVQTAHEQLEVITNMYGGVNLEQVTVQTTGQRASVTDLSTKTVMTTATTTTTAFPDWTPTLEKRGFAPLIRAFLTAVTTHGPNPVDPTGAITSHAVCRHLLSD</sequence>
</entry>
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    <accession>F9UM71</accession>
    <name>F9UM71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_0860</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888824.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78310">
        <property type="protein sequence ID" value="CCC78310"/>
        <property type="gene ID" value="lp_0860"/>
    </dbReference>
    <dbReference type="GeneID" id="57024551"/>
    <dbReference type="KEGG" id="lpl:lp_0860"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.730"/>
    <dbReference type="eggNOG" id="ENOG5030ARJ">
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    <dbReference type="HOGENOM" id="CLU_2437080_0_0_9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="97" mass="11248" checksum="05A1CC8591A7BB6F" modified="2011-10-19" version="1">MLTPKTIHDDLHEHHTQVVQLFSKHPWLIPATTLLHIIPVVVGINGFWKSRALSKQLKIEREKTKQLALQQVDKVQSAVTSQHPSLRQLFKQIRSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI5</accession>
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        <submittedName>
            <fullName evidence="5">Transcriptional attenuator, cell envelope-related, LytR family</fullName>
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        <name evidence="5" type="ordered locus">lp_1000</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMI5"/>
    <dbReference type="STRING" id="220668.lp_1000"/>
    <dbReference type="DNASU" id="1063613"/>
    <dbReference type="EnsemblBacteria" id="CCC78424">
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        <property type="gene ID" value="lp_1000"/>
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    <dbReference type="GeneID" id="66448918"/>
    <dbReference type="KEGG" id="lpl:lp_1000"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.847"/>
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    <dbReference type="HOGENOM" id="CLU_016455_2_0_9"/>
    <dbReference type="OMA" id="METIMLP"/>
    <dbReference type="PhylomeDB" id="F9UMI5"/>
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="107"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="345" mass="37694" checksum="931E6B64A2AE9965" modified="2011-10-19" version="1">MEDMPSRSEMHREKSQGNNSQGNGNGPKKKHPVRNTVLIIIAVLLVGTGAFAARTYFNAKNAADTVFKSSGIKKSRNTSAVLNGKKPVSILLLGTDTGALGRNYKGRTDTIILATINPKTKTTTLMSLPRDSEVAVSGFEQDFPTKLNAAYAYGSAGTTIKTVQKWLNVPIDYYALINMGGMKKVVDEIGGVDITPIRTFTYEGYTFTKGQKEHMNGAKALAYSRMRYDDPLGDYGRQQRQRQLITAIIGESASASNLLKQDFLNSLAKQTRTDLTFGNLTSIVTNYRSATKNIVSDHAQGTGKMIDGQSFEVVSQSEKQRVTNVLRKSLNLKAATTGEKFANQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641273.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1070"/>
    <dbReference type="EnsemblBacteria" id="CCC78477">
        <property type="protein sequence ID" value="CCC78477"/>
        <property type="gene ID" value="lp_1070"/>
    </dbReference>
    <dbReference type="GeneID" id="57024723"/>
    <dbReference type="KEGG" id="lpl:lp_1070"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.905"/>
    <dbReference type="eggNOG" id="COG4939">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_079866_0_0_9"/>
    <dbReference type="OMA" id="ADYNKNM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-920-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        <location>
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            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="200"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="308" mass="32962" checksum="5A5189440EC3655A" modified="2011-10-19" version="1">MKFKSVITGASVVAISALALAGCGSSSSSSSSSSSKKSSSSSSSAKTTKVAKLTAGSKMKAGTYNLEEENYSHGYRTKMSITVNNNGKITKSSYDQVNKNGKSKVDDTSYNKQMKKIAGTNPKTYMPKLNKTLTGSAATGNVGSIDVVTGATESSKTFQNYTQQLVQAAQAGNKSTIKIDNGAKMKDGTYKLNEKNYSHGYKVTFAITVKDNKITKSEYNQVNKNGKSKVDDAAYNKQMKKVAKTNPKTYQPALNKSLVKSSDPTKVDVVTGATESSNTFIMYAEQLQNAAQKGDTNTITVDNMIFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889134.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1238"/>
    <dbReference type="EnsemblBacteria" id="CCC78620">
        <property type="protein sequence ID" value="CCC78620"/>
        <property type="gene ID" value="lp_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1238"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1050"/>
    <dbReference type="eggNOG" id="COG1595">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_20_1_9"/>
    <dbReference type="OMA" id="TEQETHW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1061-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="182" mass="21722" checksum="0C1241611A43D8CF" modified="2011-10-19" version="1">MHADRFDNQMAFDLLARPEHQRLLYGALKAAQVTKYHPQFEDCVTVAHLTWLSAYQNYAPELPANLPDFRKFAFRRIKWRTVDYLRKQTLRTQSQVNLEHALPITIDPMTEQETHWQLTALLTELLVQCRPGERIYLTEFFFEEQTVSSIMRRHQVSRRTVYNWRASLLVKAHKLYQQQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN37</accession>
    <name>F9UN37_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1244</name>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78626">
        <property type="protein sequence ID" value="CCC78626"/>
        <property type="gene ID" value="lp_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1244"/>
    <dbReference type="eggNOG" id="ENOG50302G1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195231_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="64" mass="7209" checksum="4507EA51EF4FC7B6" modified="2011-10-19" version="1">MKKVTTALAKKNINQLLTIVNQGHDTIEVENPSTQDSAVMVSMKDWLQIVSQLAKTNHHDMEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN65</accession>
    <name>F9UN65_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">araT1</name>
        <name evidence="4" type="ordered locus">lp_1280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643296.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889168.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1280"/>
    <dbReference type="EnsemblBacteria" id="CCC78654">
        <property type="protein sequence ID" value="CCC78654"/>
        <property type="gene ID" value="lp_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="57024895"/>
    <dbReference type="KEGG" id="lpl:lp_1280"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1086"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_9"/>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="PhylomeDB" id="F9UN65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1096-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="32"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="395" mass="43836" checksum="26D618FAD2CE9E65" modified="2011-10-19" version="1">MTLFRDDLNETISHIQVSTIRQFDEEVSAIPDMVKLTLGEPDFNTPEHVKAAAKKAIDDNYSHYTGMAGLLELRQAAAHFQETKYGVHYDAEDQVLVTVGATEAIATALTTICNPGDAIIIPSPIFPAYIPIIQEAHAKPLFMDTGVNDFVITPKMVDDFIAAHPDENFKGIVLNYPNNPTGVTYVEDEIKALADCFHRHNLWVVSDEIYSELTYGSDHVSIAKFIPDEVILINGLSKSHAMTGWRIGFLFASKEMTAQLKKVHQYYVTAATTIAQKAGVEALTNGIDDAQPMRQEYQARRDFVYQTMSKLGFKIARPTGAFYIFAKIPAGFEQDSMAFCKDLARKNQLAIIPGTGFGAEGEGYVRLSYAASMEKLHQAMDRLTAYMQEPANCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN79</accession>
    <name>F9UN79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643191.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889182.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78668">
        <property type="protein sequence ID" value="CCC78668"/>
        <property type="gene ID" value="lp_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1300"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1100"/>
    <dbReference type="eggNOG" id="ENOG50309HG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159917_0_0_9"/>
    <dbReference type="OMA" id="WWRQPLL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1126-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="239" mass="26976" checksum="5D5F2EBAC297DC45" modified="2011-10-19" version="1">MIRIGKLHIKRDYIALAIFTIVQSIISWWAALDYGRSFQTASFSAAQLPLIGYTLAVAAAVFIILDRRIAPQWSLIAIGITVAFAFTNIIAKESELLYLLLTCSAWLLVMAVPRFGMQNYFGLVVFGVIMTFTIPVAVFDLQNNYLSTTFLWKLTPMLASYVFLYVPSFSRQRQINQLISAITGLLLVITIFLQPLTWQTIVAILITIAVWFSQQSFGRTRLHLMINVAVQLALILLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN96</accession>
    <name>F9UN96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ugpA</name>
        <name evidence="8" type="ordered locus">lp_1325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101355.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1325"/>
    <dbReference type="EnsemblBacteria" id="CCC78685">
        <property type="protein sequence ID" value="CCC78685"/>
        <property type="gene ID" value="lp_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1325"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1117"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="PhylomeDB" id="F9UN96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1143-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="99"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="321" mass="35785" checksum="54F473245BE94432" modified="2011-10-19" version="1">MINSFPSIKRRLKPKQSPDAHDQATVQTGSFELKRNDKYYAWLFLGPSILALSVFVFYPMLRTLYLSFFLTNSLGEPTVFVGLQNYLNLLTTKSYLASLQATGIYVVGVTVFTLIGGLLLAAAANQRVRGIELFRTMFTSTMGVSVSVSAIFWLFMFNPSVGLLNKVAIWMHLPAINWLTEPHWAMVAIIMTSVWMHLGFTFLIFFGALQVVPKTLYDAADVAGTSRRYQFIHITLPMISPTLFFAAVITLISAFKSFGLIDLMTAGGPTNATNLLVYRIYRDAFVDGNYALASTESIILAIIIAAITVIQFKLLAKRVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC5</accession>
    <name>F9UNC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1360"/>
    <dbReference type="EnsemblBacteria" id="CCC78714">
        <property type="protein sequence ID" value="CCC78714"/>
        <property type="gene ID" value="lp_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1360"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1145"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_083287_3_2_9"/>
    <dbReference type="OMA" id="AHRMTKS"/>
    <dbReference type="PhylomeDB" id="F9UNC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1172-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="159" mass="18207" checksum="AE822FBF0EA1012E" modified="2011-10-19" version="1">MMATPTKNILLDEQLCFALYTASKRYNHFYSEALAPFKLTYPQYITLLALWEKSPMTVRELGSHVNLDSGTLTPLLKRMQTQGWVERKRDTDDERQVNISLSQKAIDAKPEIFAHVNSCMDLLGLDEATYNQIRETVNFASEHIKNADPKKVDYSGEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC7</accession>
    <name>F9UNC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889230.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1363"/>
    <dbReference type="EnsemblBacteria" id="CCC78716">
        <property type="protein sequence ID" value="CCC78716"/>
        <property type="gene ID" value="lp_1363"/>
    </dbReference>
    <dbReference type="GeneID" id="57024965"/>
    <dbReference type="GeneID" id="66449215"/>
    <dbReference type="KEGG" id="lpl:lp_1363"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1147"/>
    <dbReference type="eggNOG" id="ENOG50344W0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343157_0_0_9"/>
    <dbReference type="OMA" id="APKFLVV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1174-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="10625" checksum="C7569D7AA6DAFB56" modified="2011-10-19" version="1">MFMTTGDLQRSHMIKGVVSVTKHLMFESDGVDQFERFDDLIEQVKPLLLQKAEDQGGDGLIYVNFNTEVAQMSVAPRFLIVTGYGTVVKLVDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE6</accession>
    <name>F9UNE6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
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    </evidence>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="220668.lp_1409"/>
    <dbReference type="EnsemblBacteria" id="CCC78749">
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
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        </source>
    </evidence>
    <sequence length="202" mass="22246" checksum="E17F0A7FD16053AA" modified="2011-10-19" version="1">MQVFLQGLLFGIVYIAPIGMQNLFVVSTAIEQPLQRALRVALIVIAFDTSLSLACFYGVGRLLQTTPWLELGVLLIGSLLVFYIGWNLLRQKATAMGTLDADFSYKAAILTAFSVAWLNPQALIDGSVLLAAFRVSIPAALTHFFMLGVILASIIWFIGLTSLISKFKHLMQPRVLLWINRICGGIIILYGVQLLATFITKI</sequence>
</entry>
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    <accession>F9UNG8</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC78757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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            <end position="281"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="326" mass="36992" checksum="012760E093C00046" modified="2011-10-19" version="1">MAKKLFDYQLDETVDGYFLLKDSEVRIAKNGKKFLAINFQDTSGEISGKFWDASDTDVENFQAGRIVHLKGKRENYQGNPQIKIQQMRLTHSGEPQEVQQFVEHAPLKTDTMADEINQFVFEITEPNWNRIVRHMLTTFHDRFFSYPAAKKNHHAFAGGLAYHTLSILRLAKAVADQYPHVNRALLYAGAILHDMGKTIEMSGPVSTTYTLAGNLVGHIVLIDEQIVETCQQLKIDEQSESVLVLRHTILAHHGLLEYGSPVRPHIMEAEILHDLDELDASIQMMQTSLGHAEPGTYTERIFAMDGRNFYRPTGDQTKGELPDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH0</accession>
    <name>F9UNH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxyterminal processing proteinase, S41 family, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889273.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1420"/>
    <dbReference type="DNASU" id="1062461"/>
    <dbReference type="EnsemblBacteria" id="CCC78759">
        <property type="protein sequence ID" value="CCC78759"/>
        <property type="gene ID" value="lp_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1420"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1191"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849382_0_0_9"/>
    <dbReference type="OMA" id="RASFNAM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1220-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="68"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35586" checksum="E97C525A233B6555" modified="2011-10-19" version="1">MITNKCRYGLVGLISIVLTFGLSASNRLRASFNAMPAITYMSKYGIINHRTQWQAMLHATDHGRKITSLTQLNQILRAANLHSFAVANLRQVEHATRPTKTMSAGLTIINVPAFYSSQHQLQKQYWTQLQHLIKQTKPTTDLILNFAANTGGSSAPMIAGLAAIIPDGTIYTGITNHHRNRPRMMYHGRITGGLGQDDVNFSQPTAAHFRHIYAIIGNQTASAAEVTIMALKRNPHVTLVGRSSAGYTSLNGGVFLNTAVAVMTIGTLKATVKIHGQQYFNNQPLKPDIPTLYQPLAPLQLGQSPHLDADFLSELRTIMKHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH8</accession>
    <name>F9UNH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohydrolase, MutT/NudX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101403.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889281.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1433"/>
    <dbReference type="DNASU" id="1062431"/>
    <dbReference type="EnsemblBacteria" id="CCC78767">
        <property type="protein sequence ID" value="CCC78767"/>
        <property type="gene ID" value="lp_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1433"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1200"/>
    <dbReference type="eggNOG" id="ENOG5032BFD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_29_0_9"/>
    <dbReference type="OMA" id="PSYWDIP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1228-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="15680" checksum="DB28992AC5698AFB" modified="2011-10-19" version="1">MVQIIAHTLVTAGHDVLILKRNQFERGRPNVDASYWDLPGGSALANELPQVAAKRECWEETGLKVQAERVIWEDSTFDKAKNQVYTRLVYSTQAFVTRPAISLDLTEHMAFLWMKPELILTNIRIVSYLKPILTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNP5</accession>
    <name>F9UNP5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">DNA polymerase I</fullName>
            <ecNumber evidence="3 13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">polA</name>
        <name evidence="17" type="ordered locus">lp_1508</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 13"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889348.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1508"/>
    <dbReference type="EnsemblBacteria" id="CCC78834">
        <property type="protein sequence ID" value="CCC78834"/>
        <property type="gene ID" value="lp_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1508"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1268"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_9"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="PhylomeDB" id="F9UNP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1295-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="15">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="14">
        <location>
            <begin position="301"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="16">
        <location>
            <begin position="638"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCC78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="882" mass="98802" checksum="F6004068409B90C9" modified="2011-10-19" version="1">MAKKLLLIDGNSVAFRAFFALHSQLERFVNPDGLHTNAIYGFNTMLDHMIKAVEPTDMLVAFDAGKTTFRTAMYDNYKGGRAKTPSEFSEQMPYIKQLLDAYGIKHYELKDYEADDIIGTLAAQADQTGYTTTVVTGDRDLTQLTTEHTTVAVTVKGVSEVEHYTPAHVEEKLGITPAQIIDMKGLTGDTSDNYPGVTKVGEKTALKLLKQYGTMEGIYENIDAMKQSKMKEHLIEDREQAAQAKVLATIKRDAPIDVQLADLSYDGPDLDQLAAFYQKMDFQSFLKKLHLQSDEPATPIDYTVLTKANLTELQQFTDHVDFYLEMPTPNYHTSAFAGFAIGADDHWYISRDVELLMQPTVADLLSSTTITKDVFDMKRTTVGLNRLGIQLGKVDFDLLLVSYLLDTNDNSNDLGSLAEQHGYTDLPSDETVYGKGVKRAIPEDDDVFFSHLARKLAAIASLKPQLLKELAANEQDQLYDDIEKPMANVLAQMEIAGITVDSSRLKAMGSQFTERLSEIEQTIYQEAGEEFNINSPKQLGHILFEEMKLPVIKKTKTGYSTAVDVLEKLAPEAPIVANILQYRQISKIQSTYVVGLLDAIHSADQKVHTRYLQTLTQTGRLSSVDPNLQNIPVRLEEGRKIRQAFVPSHEGWQIFSSDYSQIELRVLAHITDDENMQAAFKAGDDIHAATAMRIFHLNSAEEVTPNIRRQAKAVNFGIVYGISDYGLSQNIGITRKQARSFIDAYFKEYPGVKKYMDEIVQTAKKQGYVETISHRRRYLPDINSKSFNQRSFAERTAMNTPIQGSAADIIKIAMIKMQDKLQAAGLKATMLLQVHDELIFEAPKEEIPVLEKLVPSVMDSAVQLAVPLKVESHYGDTWYDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS9</accession>
    <name>F9UNS9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase, UbiA family</fullName>
            <ecNumber evidence="6">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640302.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1546"/>
    <dbReference type="DNASU" id="1061731"/>
    <dbReference type="EnsemblBacteria" id="CCC78868">
        <property type="protein sequence ID" value="CCC78868"/>
        <property type="gene ID" value="lp_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="57025138"/>
    <dbReference type="KEGG" id="lpl:lp_1546"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1302"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_3_1_9"/>
    <dbReference type="OMA" id="MSIIALK"/>
    <dbReference type="PhylomeDB" id="F9UNS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1329-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901663">
        <property type="term" value="P:quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="322" mass="36382" checksum="C88B4999D42E9482" modified="2011-10-19" version="1">MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVAIALFVTGFNNVQDYYLAKDLHYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVRTNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVEGFGVFFLSVYMNVATPVLAGFKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGHRWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNTAPQNLMMFQGMQLLGLILGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNX0</accession>
    <name>F9UNX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepP</name>
        <name evidence="6" type="ordered locus">lp_1595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1595"/>
    <dbReference type="EnsemblBacteria" id="CCC78909">
        <property type="protein sequence ID" value="CCC78909"/>
        <property type="gene ID" value="lp_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1595"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1344"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_0_9"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="PhylomeDB" id="F9UNX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1371-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="135"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="37871" checksum="728FCB46591529E2" modified="2011-10-19" version="1">MSRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTAFAGQYDDQHLVITRDYLGAVCDIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDVVDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMREIDVSNLLDAFMRTHGASGPSFTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTAYQAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLISKNTTGTLVANSVITVEPGVYFPDLGGMRIEDDVLVTAEGHERLTTATRDLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ6</accession>
    <name>F9UNZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamin pyrophosphokinase</fullName>
            <ecNumber evidence="6">2.7.6.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tpk</name>
        <name evidence="6" type="ordered locus">lp_1622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-04" db="PDB data bank">
            <title>Crystal structure of the lp_1622 protein from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Vorobiev S.M."/>
                <person name="Abashidze M."/>
                <person name="Seetharaman J."/>
                <person name="Zhao L."/>
                <person name="Maglaqui M."/>
                <person name="Foote E.L."/>
                <person name="Ciccosanti C."/>
                <person name="Janjua H."/>
                <person name="Xiao R."/>
                <person name="Acton T.B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645150.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889449.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3CQ9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B/C/D=1-219"/>
    </dbReference>
    <dbReference type="PDBsum" id="3CQ9"/>
    <dbReference type="SMR" id="F9UNZ6"/>
    <dbReference type="STRING" id="220668.lp_1622"/>
    <dbReference type="DNASU" id="1063722"/>
    <dbReference type="EnsemblBacteria" id="CCC78935">
        <property type="protein sequence ID" value="CCC78935"/>
        <property type="gene ID" value="lp_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1622"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1370"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_0_9"/>
    <dbReference type="OMA" id="ITYCPEG"/>
    <dbReference type="PhylomeDB" id="F9UNZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1397-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="5">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3CQ9"/>
        </source>
    </evidence>
    <sequence length="219" mass="24125" checksum="1DB834BE400695D0" modified="2011-10-19" version="1">MATIVNLLVGGPTANYPADLTTIPGPWVGADRGALRLVKRGIQPVMVVGDFDSIDAAELQTVKDALVGAIVVKPDQDHTDTQLAIKSIFEQLQPDEVHLYGATGGRLDHLLANMWLVLDPVFRQWAPQIKLIDKQNSVRFFLPGDYQITKEADKRYLAFVPLMPMHLTLPDEKYQLDAAYNAYPISWASNEFSGNTGHFSFDAGVLAVIQSRDDSMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP15</accession>
    <name>F9UP15_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1645"/>
    <dbReference type="EnsemblBacteria" id="CCC78954">
        <property type="protein sequence ID" value="CCC78954"/>
        <property type="gene ID" value="lp_1645"/>
    </dbReference>
    <dbReference type="GeneID" id="57025225"/>
    <dbReference type="KEGG" id="lpl:lp_1645"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1390"/>
    <dbReference type="eggNOG" id="ENOG503328X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074053_2_0_9"/>
    <dbReference type="OMA" id="CWVRCEN"/>
    <dbReference type="PhylomeDB" id="F9UP15"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1417-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17827" checksum="C87E1FF80FE38FA9" modified="2011-10-19" version="1">MTTLIDITGQKFGRLTVIRRCGTAKNGNALWLCQCRCGNQTKADSYALRHGRARSCGCLTRESRSQLIRRNPKTAASMGRLSNLKIHDHHTDLPSKIMSKRNKSGVIGVSWDSNTQKWVATFFYKGRYLLHKPFQHFEDAVLARQAMENRYLNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP38</accession>
    <name>F9UP38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG1</name>
        <name evidence="1" type="ordered locus">lp_1674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1674"/>
    <dbReference type="EnsemblBacteria" id="CCC78977">
        <property type="protein sequence ID" value="CCC78977"/>
        <property type="gene ID" value="lp_1674"/>
    </dbReference>
    <dbReference type="GeneID" id="57025248"/>
    <dbReference type="GeneID" id="66449545"/>
    <dbReference type="KEGG" id="lpl:lp_1674"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1413"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_9"/>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="PhylomeDB" id="F9UP38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1440-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="25748" checksum="FF7E34223D4CC011" modified="2011-10-19" version="1">MSVDEVILVTGAAKGIGLATVKRLAAQGASVILNVHHEIEAADWQALTAEYPRLTQLVGDVSDDQTAADLIETVMTNFGRLDGLVNNAGVTHDQLLTRLHAEDFMSVIQTNLLGTFNMTKYALKVMQRQRQGAIVNVASVVGLHGNIGQANYAASKAGIIGLTKTTAKEAARRQVRCNAVAPGMITTAMTAQLNDRVTAAALSDIPLKRFGTPDEIAQAIDFLLHQPYLTGQVLTVDGGMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB7</accession>
    <name>F9UPB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase, GNAT family, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1766"/>
    <dbReference type="EnsemblBacteria" id="CCC79056">
        <property type="protein sequence ID" value="CCC79056"/>
        <property type="gene ID" value="lp_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1766"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825719_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7682" checksum="8FDAB3E401349406" modified="2011-10-19" version="1">MGGGRQILHTLEQDVYFSHAHRVEIPASVTAHLFYQHFGYRPKPGGIYPDDEGLYRLEKFPHESFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE4</accession>
    <name>F9UPE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-09" db="PDB data bank">
            <title>Crystal structure of putative N-acetyltransferase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Chang C."/>
                <person name="Li H."/>
                <person name="Cobb G."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3EFA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.42 A"/>
        <property type="chains" value="A=1-144"/>
    </dbReference>
    <dbReference type="PDBsum" id="3EFA"/>
    <dbReference type="SMR" id="F9UPE4"/>
    <dbReference type="STRING" id="220668.lp_1797"/>
    <dbReference type="DNASU" id="1063725"/>
    <dbReference type="EnsemblBacteria" id="CCC79083">
        <property type="protein sequence ID" value="CCC79083"/>
        <property type="gene ID" value="lp_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1797"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1518"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_6_1_9"/>
    <dbReference type="OMA" id="HYLTIHA"/>
    <dbReference type="PhylomeDB" id="F9UPE4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1546-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
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        <source>
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</entry>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79089.1"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <sequence length="110" mass="12225" checksum="3ED4E2F3B4DFECF9" modified="2011-10-19" version="1">MQNLIPGDMLEVNQKLKWELDAGMTADESSVINEAVLAGTQYFVDEALEGSYWTVKWAADGQTIELYGTTGTVVGRIKPLSATLENDFRQDSQGLFIRIEKEVAVIVRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPF4</accession>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="lp_1811"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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            <end position="67"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCC79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG6</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889619.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1823"/>
    <dbReference type="EnsemblBacteria" id="CCC79105">
        <property type="protein sequence ID" value="CCC79105"/>
        <property type="gene ID" value="lp_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1823"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1541"/>
    <dbReference type="eggNOG" id="ENOG5030AKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1883133_0_0_9"/>
    <dbReference type="OMA" id="PHHYLAM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1568-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="133" mass="14977" checksum="EC5601E44BF906D3" modified="2011-10-19" version="1">MMKKATWRLLALLIGQPIVIYTAQRALLTTIPSRYGLLGAIAYTSDPHHYLAMLESALIPALLIALKPLNRYAAPYTWSTILKRTLGWWLFGMNWFILISLFVQASWLSWGIFLWSLGGAMVLLAKLLGVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ2</accession>
    <name>F9UPQ2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101598.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889705.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1931"/>
    <dbReference type="EnsemblBacteria" id="CCC79191">
        <property type="protein sequence ID" value="CCC79191"/>
        <property type="gene ID" value="lp_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1931"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1628"/>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035128_1_0_9"/>
    <dbReference type="OMA" id="CRYLRRM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1653-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="559" mass="63913" checksum="8C345D659621D19D" modified="2011-10-19" version="1">MDWEDYFPTAIAERGYDYYLQGYVTDLKRTKTQITAMVTGTQDYGVVIDLANGDFHGGACECPYANSHPYCKHMAAVLCQATAADKPASQQQVSKAPTSFDSLEQTATKLVERATDRQVRDFLSVVLAHDKHLVQLFRTVMGETNVVTDLPEYLASVDDLFDTNADGGGFIDYDAATDFGDEALTLLKEEVQPLVDHGEYGLVFQILAHLMLKIDHVDIDDSDGEIMMIMSASDDLWEAVLTKADADVQQQVFDWLCKQLTKSLNIIEDTLDDLLFTYFKTPAFIDAKLVYTAKRFRAVQKHPDLWDYDWQIKKWLKHYLQMMSAAHVPDKQIIKFCGANLAIPQVRLFYSQFCLQHQDEAHAVQLLKDGKKLVTDDPSMLAELSRQLKDAYQQLGEKQLYRQELWQLLTEYAPADEMLFSELKQSYPTTDWPAVREQLLTAIAKNSNVDLKPLYVQENLLNPLLKAVVAADGLWDLRIYEPLLKPRFSDLLLAKYDHEVRKMATTTGTRRKYQQLVGILKRMLAYPAGKSTVQAIVHDWQQQYPRRSAMMDELSRLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPU6</accession>
    <name>F9UPU6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable cell wall amidase lytH</fullName>
            <ecNumber evidence="5">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lytH</name>
        <name evidence="8" type="ordered locus">lp_1982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in cell-wall metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889749.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1982"/>
    <dbReference type="EnsemblBacteria" id="CCC79235">
        <property type="protein sequence ID" value="CCC79235"/>
        <property type="gene ID" value="lp_1982"/>
    </dbReference>
    <dbReference type="GeneID" id="57025560"/>
    <dbReference type="KEGG" id="lpl:lp_1982"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1675"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_1_1_9"/>
    <dbReference type="OMA" id="WHTNLNI"/>
    <dbReference type="PhylomeDB" id="F9UPU6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1699-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017273">
        <property type="entry name" value="LytH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037730">
        <property type="entry name" value="CWA_LytH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="7">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="282" mass="30967" checksum="62C7B09C406185C9" modified="2011-10-19" version="1">MQVLKQFWRQITVTVIFIGLVIGFVVLLATNNTATVNIANVNIRSGPGMSYAIEDATSKGTKVHIMKRKNNWLYVRYADHKFGWIASWLVNEHNSQLTKTTKISEATIVLDPGHGGSDSGALSSKGKMEKTYTLRVAKAVAKKLRAAGAHVVLTRDSDEYVGLSARPAIANKLHADAFISFHFDSSPEKNTASGITTYYYHKSTSLALAKALNNNVSTLPIPSKGTDFGDFLVIRDNSRPSVLMELGYINDKSDFKTISSKKYPQEVAHAVYAGLSTYFANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPZ0</accession>
    <name>F9UPZ0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroI</name>
        <name evidence="2" type="synonym">aroK</name>
        <name evidence="3" type="ordered locus">lp_2033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640717.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889793.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2033"/>
    <dbReference type="EnsemblBacteria" id="CCC79279">
        <property type="protein sequence ID" value="CCC79279"/>
        <property type="gene ID" value="lp_2033"/>
    </dbReference>
    <dbReference type="GeneID" id="57025585"/>
    <dbReference type="KEGG" id="lpl:lp_2033"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1718"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_3_9"/>
    <dbReference type="OMA" id="DTDIFMQ"/>
    <dbReference type="PhylomeDB" id="F9UPZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1740-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="173" mass="18658" checksum="3C2E830F7D26D750" modified="2011-10-19" version="1">MRAILIGFMGSGKTTVGRLLAAGLATKHADLDDLIVQRAGRSITTIFAEQGEGYFRQLEHQTLLQALETPGILSTGGGTPTIAMNAISLKQSTVPVIWLTASDQTTINRVKNDTSRPLVNELDTGALIALKQRRQALYAAAADLTIATDQLTPQQIARQIQQWLNQQPVALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ84</accession>
    <name>F9UQ84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosortase (Transpeptidase), TIGR03110 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101667.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2143"/>
    <dbReference type="EnsemblBacteria" id="CCC79373">
        <property type="protein sequence ID" value="CCC79373"/>
        <property type="gene ID" value="lp_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2143"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1814"/>
    <dbReference type="eggNOG" id="ENOG502ZNKB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364439_0_0_9"/>
    <dbReference type="OMA" id="IMAFISR"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1834-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017541">
        <property type="entry name" value="Exosort-XrtG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03110">
        <property type="entry name" value="exosort_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="199" mass="22830" checksum="CD6C60B22B6F41A6" modified="2011-10-19" version="1">MNVKILLGIVIWLYGLSVLKRARLSAFYFIVGSAGLFFILTAISRPYWVWFFTHAVIHGVALFSDITGWCSIMFKMGLVYIINSGNPVIMSIDYECSGIIETCAFISLVAFYPAYQRREKVFYGVFGLLYIYLINVLRLSVVIVIVHFGGGQTFFLAHSVIGRLLFYVLVIVLYYNVFTYSQLARGLYQQFIDCRERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ92</accession>
    <name>F9UQ92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase complex, E1 component,beta subunit</fullName>
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    <gene>
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        <name evidence="2" type="ordered locus">lp_2153</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889895.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2153"/>
    <dbReference type="EnsemblBacteria" id="CCC79381">
        <property type="protein sequence ID" value="CCC79381"/>
        <property type="gene ID" value="lp_2153"/>
    </dbReference>
    <dbReference type="GeneID" id="49394321"/>
    <dbReference type="GeneID" id="57025687"/>
    <dbReference type="GeneID" id="66449916"/>
    <dbReference type="KEGG" id="lpl:lp_2153"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1822"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_9"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="PhylomeDB" id="F9UQ92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1842-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35439" checksum="145ED046363A0271" modified="2011-10-19" version="1">MSKKTYIQAITDALRLELGSDEKTLVFGEDVGKNGGVFRATDGLQAEFGEDRVFDTPLAESGIGGLSIGLALEGFRPIPEIQFLGFIFETLDSIAGQMSRERFRTGGTRHMPITIRSPYGGGTHTPEMHADSLEGYLAQIPGLRVVTPSNPYDAKGLLISSIRNNDPVFFLENLKLYRSMKADIPDEAYTVPLDKANVVREGTDISLIAYSAQVNQSLKVAEKLEKEGISVEVVDLRTLSPLDEETILKSVQKTGRAVAIQEAQRQAGIAANVASLIAEKGALYLSAPVGRVYAPDTVYPFGLAEDDWLPAEDEIEAKTREILNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB9</accession>
    <name>F9UQB9_LACPL</name>
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        <submittedName>
            <fullName evidence="8">Cell division initiation protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">divIVA</name>
        <name evidence="8" type="ordered locus">lp_2189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640850.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2189"/>
    <dbReference type="EnsemblBacteria" id="CCC79408">
        <property type="protein sequence ID" value="CCC79408"/>
        <property type="gene ID" value="lp_2189"/>
    </dbReference>
    <dbReference type="GeneID" id="57025717"/>
    <dbReference type="KEGG" id="lpl:lp_2189"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1849"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076854_0_2_9"/>
    <dbReference type="OMA" id="QSIFVAQ"/>
    <dbReference type="PhylomeDB" id="F9UQB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1869-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="232" mass="26174" checksum="2BF2E15016775E39" modified="2011-10-19" version="1">MVLSPDDIHNKEFSTKLRGYNIDEVNDFLEQIIKDYQITLKQNKDLQERLDSSEGKLKYFNELKDSLNQSILVAQEAADKVKTNSKKEADIITREAQKQASDIVSEATDKSNQMIDEASQKAKRLSVETDDLKKQTRVFRQRLQVMLESQLEVVKSKDWDQLLSETNTADYAEIQHVLKEDNLDNSGDASVNSEATVEITEATSGETPVADGGDQVQQQTVVIFPDDDSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX3</accession>
    <name>F9UQX3_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Prophage P2a protein 24 endodeoxyribonuclease RusA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2433</name>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890126.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2433"/>
    <dbReference type="EnsemblBacteria" id="CCC79612">
        <property type="protein sequence ID" value="CCC79612"/>
        <property type="gene ID" value="lp_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2433"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2056"/>
    <dbReference type="eggNOG" id="COG4570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136719_0_0_9"/>
    <dbReference type="OMA" id="WPCKLKF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2098-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14471" checksum="D40238126FC8FF07" modified="2011-10-19" version="1">MNKVVIKGELPSLNEYIKAERANRYAAANLKKRYTALCSVYARASRNSGVEFSWPCKLKFTWYTKNNRKDADNIAFAKKFVLDGFMKAGLLGNDNRKHITGFQDEFAVDKRNPRVEIDEITEDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR20</accession>
    <name>F9UR20_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2488a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2488a"/>
    <dbReference type="EnsemblBacteria" id="CCC79659">
        <property type="protein sequence ID" value="CCC79659"/>
        <property type="gene ID" value="lp_2488a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2488a"/>
    <dbReference type="eggNOG" id="ENOG5030AYF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169537_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2151-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="43" mass="4795" checksum="AE4925525B76D218" modified="2011-10-19" version="1">MSFFSDLHFLPGTHTSSHTSYVSNQPLGTFYQFVLNVIAAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR40</accession>
    <name>F9UR40_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890193.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2513"/>
    <dbReference type="EnsemblBacteria" id="CCC79679">
        <property type="protein sequence ID" value="CCC79679"/>
        <property type="gene ID" value="lp_2513"/>
    </dbReference>
    <dbReference type="GeneID" id="57025944"/>
    <dbReference type="KEGG" id="lpl:lp_2513"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2116"/>
    <dbReference type="eggNOG" id="ENOG5030ABW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2233108_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2172-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0079">Bacteriocin immunity</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="105" mass="11723" checksum="BD86BEDC0318779A" modified="2011-10-19" version="1">MAKAKARTTQPNERLSAQLALASMAIEIRSDVVLTRLVARARRRLNRSGDSIAIAHQIAVDLGYYLVCHQYKMPRAAYDLLAVAYEVSVETPTRATIIQLPSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR44</accession>
    <name>F9UR44_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface hydrolase, DUF915 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2519"/>
    <dbReference type="ESTHER" id="lacpl-LP.2519">
        <property type="family name" value="Duf_915"/>
    </dbReference>
    <dbReference type="DNASU" id="1062707"/>
    <dbReference type="EnsemblBacteria" id="CCC79683">
        <property type="protein sequence ID" value="CCC79683"/>
        <property type="gene ID" value="lp_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2519"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2120"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_0_0_9"/>
    <dbReference type="OMA" id="HYNIVAH"/>
    <dbReference type="PhylomeDB" id="F9UR44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2176-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388107" evidence="2">
        <location>
            <begin position="29"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="31708" checksum="4C800C30DD7EB19D" modified="2011-10-19" version="1">MKQIKWWLLAVLLVVGLTGCGSQTTKKQATQQAASTKKISPYVNQQTPTFYVHGFQGSAKSTNTLIAHAEKTAHAHKVLVATVSTSGQVTLTGKWRGRVRNPIIQVVFKNNLAQYDQQSAWLAKVITTVQQQHAFKHYNIVAHSAGCVASVNMLMTQQTTTFPKINKLVTIAGPFDGVVGEDDVANQNSFLTSGQPKYLHAAYELLAAKRNNFPKNVQLLNIVGTLNDGSHSDSLVTNVSARSIKYLLRGRDVDYTEKDFYGAHAQHSQLHENAKVALAVDRFLWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR55</accession>
    <name>F9UR55_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hdhD1</name>
        <name evidence="8" type="ordered locus">lp_2532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101815.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2532"/>
    <dbReference type="DNASU" id="1062719"/>
    <dbReference type="EnsemblBacteria" id="CCC79694">
        <property type="protein sequence ID" value="CCC79694"/>
        <property type="gene ID" value="lp_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2532"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2130"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_0_0_9"/>
    <dbReference type="OMA" id="NYSSMYQ"/>
    <dbReference type="PhylomeDB" id="F9UR55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2187-MON"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="6">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="7">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="36920" checksum="101A68214F6090C8" modified="2011-10-19" version="1">MKYGIIGAGAMGYRYGVMLQENAGVDVDFIDTWGPNVAKVREQGGVDVARDHQNHHVVPINIYYPEEYQGHPDVWIVFKKQMQLADELKRDASLFHEDQYVFAAMNGMGHFEKIAQYFPENHIIGGTAMIATVLNGPGTVDFMGPKGSEAMHMSKYAGHIDTTTKQVMADFKAADLNPIWSDNFMGMCMSKVVFNAVTNSLCTMFEIQMGQFIEYPGVKDMATQMFNEAYDACERAGIKLIETRQEEIDSVETVSRAYKYHYPSMYQDFSKGRPTEVDYINGYIAKIGREHDYVCRVHEFVTHEVHLAEMMRQYRHPEIPVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA6</accession>
    <name>F9URA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formate C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pflF</name>
        <name evidence="5" type="ordered locus">lp_2598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.54" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101845.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2598"/>
    <dbReference type="EnsemblBacteria" id="CCC79745">
        <property type="protein sequence ID" value="CCC79745"/>
        <property type="gene ID" value="lp_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2598"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2181"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009096_0_1_9"/>
    <dbReference type="OMA" id="HVQYNIV"/>
    <dbReference type="PhylomeDB" id="F9URA6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2236-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="22"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="693"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="814" mass="91615" checksum="A1303BC54F1A17A0" modified="2011-10-19" version="1">MIMSETLTKTTTTINHFGKLTPMMDRLRDSIIDAKPYVDPERAILTTETYRQHQDEQVDILRAKMLEHVLDKMSIFIEDDTLIVGNQARQNRWAPVFPEYSMNWVIDELDTFEKRPGDVFYITEKSKEELRAIAPFWKHNTLEDRGYASFPEASRIFYDLGIIGADGNITSGDGHIAVDYKNVVNKGLKWYEDRIKTALANLDLTDFNQQKQYYFYKAGLIVIDAIHNFAKRYAQLASKQAQNTTSATRKAQLEKIAQILNKVPYEPANSFYEAIQAVWLVHLTLQIESNGHSVSYGRLDQYLAPFYEHDLKTGAIDANGATELLTNLCLKTLTINKVRSWQHTEFSAGSPLYQNITIGGQTPDGKDAVNPTSYLILRAIAQAHLPQPNLTVRYHHGLSDKFMRECVEVIKQGLGMPAFNNDEIIIPSFIRRGVKKEDAYNYSAIGCVETAIPGKWGYRCTGMSFINFPRVLLLIMNGGIDPESGKRLLPDYGKFTDMTSFDQLMTAWDKALREMTRQSVIIENSCDLALEQNYPDILCSVLTDDCIGRGKTIKEGGAVYDFISGLQVGIANLADSLAAIKKLVFEEKKLTTTQLWHALTTDFADEDGEKIRQMLINDAPKYGNDDDYVDDLIVEAYKPYIDEIAKYKNTRYGRGPIGGLRYAGTSSISANVGQGHSTLATPDGRHARTPLAEGCSPEHAMDTDGPTAVFKSVSKLSTKDITGGVLLNQKMSPQILRSDESCMKLVALLRTFFNRLHGYHVQYNIVSRDTLIDAQNHPDKHRDLIVRVAGYSAFFVGLSKETQDDIIERTEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG3</accession>
    <name>F9URG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
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                <person name="Leer R."/>
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                <person name="Nierop Groot M.N."/>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        </source>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    <accession>F9US14</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
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                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
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        <property type="protein sequence ID" value="CCC80003.1"/>
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    <dbReference type="EnsemblBacteria" id="CCC80003">
        <property type="protein sequence ID" value="CCC80003"/>
        <property type="gene ID" value="lp_2927"/>
    </dbReference>
    <dbReference type="GeneID" id="66450539"/>
    <dbReference type="KEGG" id="lpl:lp_2927"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2445"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_1516061_0_0_9"/>
    <dbReference type="OMA" id="ATIGPPQ"/>
    <dbReference type="PhylomeDB" id="F9US14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2499-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="177" mass="18857" checksum="A2FBA68C18AB3CBF" modified="2011-10-19" version="1">MPVVISSLIPVVAPVKRQVINVTTLANTVHLYGLLGFKQQIIPATDQIVAPFAGVITAVAANQRLIGFRAANGLVGWLRIGQLTSALESPTFKFNVKPGDWVVAGQMLVEVISLLTQRLQPVKTTVVLTIRHAVVRVRERLLAASNQVDPMGTVISGITTSMAGNHRVATIGPPQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US15</accession>
    <name>F9US15_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase, GGDEF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642201.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890518.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2929"/>
    <dbReference type="EnsemblBacteria" id="CCC80004">
        <property type="protein sequence ID" value="CCC80004"/>
        <property type="gene ID" value="lp_2929"/>
    </dbReference>
    <dbReference type="GeneID" id="57026275"/>
    <dbReference type="GeneID" id="66450540"/>
    <dbReference type="KEGG" id="lpl:lp_2929"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2446"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_9"/>
    <dbReference type="OMA" id="ERMTISM"/>
    <dbReference type="PhylomeDB" id="F9US15"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2500-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="242"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="376" mass="44138" checksum="65AD2E21E587DFBF" modified="2011-10-19" version="1">MTWSNWRISPFVTSIFFILGVLTLYWVLFNWITTWFHARHINIDDDTVNAWHGVIYMLVFVFVMQLSVVGKADSWEFVNFHLIAVVFCSFFLNIRMPYYSLLPVVIVYMVFDQSIFYWESWSYAVVFVLFFWSMNYLRLWVPKHRYPWLYYYGAVAFYGGILWGLIKLKYSLDWDNTLQEYGYLMIFAGLLYAYVNMLTQDSEIKLRLAQFASHDALTETENFAAYTEHIKYLFDDSAKNNLNLSMMMFDIDHFKHVNDTYGHLAGDRVLQEVAATVTTVLAANDEKVKLYRTGGEEFNVLFPGYDLASTKVIVRQVFEAVNHLVVKYEDEEINVSISVGVSTLHQADGSPIDLYNRVDQNLYFSKRHGRMRVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG4</accession>
    <name>F9USG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642294.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890608.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3040"/>
    <dbReference type="EnsemblBacteria" id="CCC80094">
        <property type="protein sequence ID" value="CCC80094"/>
        <property type="gene ID" value="lp_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3040"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2540"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="PhylomeDB" id="F9USG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2587-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="593" mass="65861" checksum="9301358378E14B9B" modified="2011-10-19" version="1">MSDLRNAGKYYWHYLKRYWLGFLLSVILIAFSTWCIVVAPTYLGRAVEELTQYLQQWTNQATRAQASLQPFNRTLIIYVLLYVGDASTIFIASLILARVTAFSTGTMRVGLFRKMQRMKVQYFDTHSDGDILARFTSDLDNIFNAMNQALLEILLAVAQFVGLLIVMFNQNTTMAWVTMASTPVALIIAAFVMHKAGVAVNQQQDDIGQLNGYINEQITGQKVLITNGLQQDSLKGFHQYNGKVRQSALTGQIWSGILNPLMQGMSLLNTAIVIFFGSWLALNGSMSTGAALALVVVFVNYAQQYYQPIMSLTSLYSMIQLAITGARRVDEVRNQPDEVSPANGQALDGIHDELLIDNVRFSYLPGKEILHGVSIHVHRGEMVALVGPTGSGKTTVMNLLNRFYDVDSGAITFDGVNIQDFDLQVLRQNVGIVLQEPQLFTGTIADNIRYGDPTASMDRVIDAAKQANIHDFVMSLPDGYQTRVSDEQSIFSAGQKQLMSIARTILTNPKLLILDEATSNVDTVTEANIQAAMDNVIQGRTSFVIAHRLKTILNADKIVVLKDGQIIEQGNHHDLLAANGFYAELYRNQMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK6</accession>
    <name>F9USK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase (NAD(P)+)</fullName>
            <ecNumber evidence="3">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabD</name>
        <name evidence="3" type="ordered locus">lp_3092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3092"/>
    <dbReference type="EnsemblBacteria" id="CCC80136">
        <property type="protein sequence ID" value="CCC80136"/>
        <property type="gene ID" value="lp_3092"/>
    </dbReference>
    <dbReference type="GeneID" id="57026402"/>
    <dbReference type="KEGG" id="lpl:lp_3092"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2582"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_9"/>
    <dbReference type="OMA" id="NDDLGEV"/>
    <dbReference type="PhylomeDB" id="F9USK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2629-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="470" mass="50404" checksum="08CD302D816B6144" modified="2011-10-19" version="1">MAYQTINPYTNEVVKTYDNATTDQIEQALTTGDALYHQWRHEPVSSRAASLHKIAALLREHKDELAKIATIDMGKLLSESQGEVELCAMIADYYADHGAELLAPTPISTQATGDAEIEKQATGVLMLVEPWNFPYYQIMRVFAPNYMVGNPMILKHASNTPGSAAAFAKIVEEAGAPAGSLTNLFLNYDQVSDIIADPRIQGVALTGSKRGGQAVAKAAGANLKKSSMELGGSDAFVVLADADIDEAVNLAWRVRLYNAGQVCTSSKRFIVAADVYDDFLAKLKERFAKLVPGDPMDPQTTLAPMNSKRAKEKLQDQVDRAIAGGATVAYGNEPIDLPGQFFQPTILTDIDQDNPLFYEEMFGPVAQVFKVDSEQAAIDLANNSELGLGGIVFAGTAAHGKAVAQQIETGMVFVNTFLSSLPELPFGGVKGSGYGRELSSLGLMAFVNEKLVVTAQKPDYDNGAGGLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK9</accession>
    <name>F9USK9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102039.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890653.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3095"/>
    <dbReference type="EnsemblBacteria" id="CCC80139">
        <property type="protein sequence ID" value="CCC80139"/>
        <property type="gene ID" value="lp_3095"/>
    </dbReference>
    <dbReference type="GeneID" id="57026405"/>
    <dbReference type="KEGG" id="lpl:lp_3095"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2585"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_9"/>
    <dbReference type="OMA" id="MRHNELK"/>
    <dbReference type="PhylomeDB" id="F9USK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2632-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="14121" checksum="96008D0234061FC0" modified="2011-10-19" version="1">MLKERVTAQPRYRNEFDATMQLIRGKWKIMILFELAEVKVSRFADLQHHIQAVSHKTLASQLKELEQDELIERHDFKTAQPHVEYRLTAKGQSLIPILDAICTWGDQHVDPALIERSLCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM8</accession>
    <name>F9USM8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3115"/>
    <dbReference type="EnsemblBacteria" id="CCC80158">
        <property type="protein sequence ID" value="CCC80158"/>
        <property type="gene ID" value="lp_3115"/>
    </dbReference>
    <dbReference type="GeneID" id="57026424"/>
    <dbReference type="KEGG" id="lpl:lp_3115"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2604"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_1_0_9"/>
    <dbReference type="OMA" id="YAYTEAV"/>
    <dbReference type="PhylomeDB" id="F9USM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2651-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678936" evidence="2">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="162"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="39285" checksum="619E261191DC2B27" modified="2011-10-19" version="1">MQKRLRLSLGMLLAVVASLLMMGQVASADQGVGFEITPVQSSSQVDKRLSYFDLKLKPRQTQTVAVKIHNTASEPITINIGIAKATTNINGVVEYKHTNNRSANLPYDISKLVTTDEPQVKLAKGQVKTVKFQIKMPAQSYQGILAGGITFLKKATATDTKKAVAVNNQYAYTEAVILHGSKDLTTNQLTMNKITVKQLNGRNAINFPLVNHTAAYLNKVQTNIKIYHRGGSQVVYHQKLANGQMAPNSIYKLPLQTGEKALAAGKYTAVVKVTSKKQHWQFKQNFVITKGQADTLNKTAVLKQGPNWWLYIGIGLLLLLLIILVIWYIWRKQKKIKSLEKQLAEKNRQDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR0</accession>
    <name>F9USR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA1</name>
        <name evidence="8" type="ordered locus">lp_0076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100870.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888155.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0076"/>
    <dbReference type="EnsemblBacteria" id="CCC77641">
        <property type="protein sequence ID" value="CCC77641"/>
        <property type="gene ID" value="lp_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0076"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.63"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_5_1_9"/>
    <dbReference type="OMA" id="GITIFSH"/>
    <dbReference type="PhylomeDB" id="F9USR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-63-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="672" mass="73933" checksum="3B78D0B6F5F454D5" modified="2011-10-19" version="1">MKRIVAGIIAHVDAGKTTLSEALLYRSGALRQLGRVDNGDAFLDTDVLEKQRGITIFSHQANLQYKDINLTLLDTPGHVDFATQTEQVLSVLDVAILVVSATDGVQGYTRTLWRLLARYDVPTILFVNKMDAPGTDSDQLIQQIQQTLSPGCVAFNTPGAGDTLEDRPVIPTAAVEDIAMQNDEVLTDYLETGTLSDATIRQMIQRREVFPCYFGAALKLDGVDALMTGLDYWTTPQLTRPEFGARVFKITHDDQGERLTWIRMTGGTLRPKDIVYDDQKVNQLRVYNGTKYATTSALTAGSVGAITGLTGTRPGQGLGQAATSLQPVMQPVLTYALDPQREELHTCLAALRQLEDEDPQLHVTWSEPLQELRVQVMGTIQLEVLQQILQDRFQLTVKFGTGSILYQETITQAVEGVGHFEPLRHYAEVHLLLTPAPRGSGLQFTTDCSLEVLGRNWQHQVVSNLQAKTQVGVLIGAPLTDVKVTLVSGRASNVHSVGGDFREATWRALRQGLMMLNQRGDCQLLEPWYRFRLEIGQEQVGRAMTDIQRMNGQFDAPVANTSVATDGTGLTTITGTAPVAAMQDYSQTVRAYTHGQGQLECIVDGYRPCHNEMAVVDKAEYVPTADLENTPDSVFCAHGAGYPVAWNQVPEMAHVPYVYSNTELAHFKASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV4</accession>
    <name>F9USV4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug-efflux transporter, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643663.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0132"/>
    <dbReference type="DNASU" id="1061337"/>
    <dbReference type="EnsemblBacteria" id="CCC77685">
        <property type="protein sequence ID" value="CCC77685"/>
        <property type="gene ID" value="lp_0132"/>
    </dbReference>
    <dbReference type="GeneID" id="57026972"/>
    <dbReference type="KEGG" id="lpl:lp_0132"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.109"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_57_3_9"/>
    <dbReference type="OMA" id="CPIFGYL"/>
    <dbReference type="PhylomeDB" id="F9USV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-107-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="410" mass="44523" checksum="455C1D57745443A9" modified="2011-10-19" version="1">MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFAADYAISAISAPLWGIIADKKGRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFAGFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVIGGLLAQLFSIRNTFFITAGLLMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAPIISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVIMYFPQGIVTSVVALGILRFAIGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGNMFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPDIWKNGKRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT05</accession>
    <name>F9UT05_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_0197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100913.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0197"/>
    <dbReference type="EnsemblBacteria" id="CCC77736">
        <property type="protein sequence ID" value="CCC77736"/>
        <property type="gene ID" value="lp_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0197"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.161"/>
    <dbReference type="eggNOG" id="COG3827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316374_0_0_9"/>
    <dbReference type="OMA" id="KPEIWVK"/>
    <dbReference type="PhylomeDB" id="F9UT05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-158-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00222">
        <property type="entry name" value="CollagenBindB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008454">
        <property type="entry name" value="Collagen-bd_Cna-like_B-typ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041171">
        <property type="entry name" value="SDR_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17961">
        <property type="entry name" value="Big_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05738">
        <property type="entry name" value="Cna_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389118" evidence="7">
        <location>
            <begin position="29"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Big_8" evidence="10">
        <location>
            <begin position="251"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="9">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="CNA-B" evidence="8">
        <location>
            <begin position="619"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="9">
        <location>
            <begin position="719"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1006" mass="105200" checksum="B5513793786FBB4B" modified="2011-10-19" version="1">MRLIDFKTWIMGTAAMLTLIVTNQTVSAADTATTATETTQTSGSSTLANQVVLRQTTSSSSSSSSSSSSSSSSSSSSSSSSSTKASATGAATETATSKAVTTSESSTQSSSTTATSQTTSGVTAAQATTDSTDTTATSRATANAKADQRAASAKANNEQATTQNQQQTTNMYSGVVTSQKDSARTATTTDQATASVATLSRMSRASLRSLAQRATVAVQGLDATDATVTDDDGVTYSATDVLSLYANYIAKYHWSIADDVSVTAGSTATVTLPENVVFTNGTQHIDVQKSDGTVVGTFTAETGSQTGTLTFNDYYATSDRYNRQGDLTFYVTGTSATTGSSTTGINKVGWADSNSLDADGNPTKMIWQVVANINSEKWQQVAIVDQLGLYQTHEGTMTLETGHYTDGAFVKDAALGTYGFATQQFTYADGVSTPQVTVTVVGQQMTINIDQLDVAVNIFYEVGLTVGHTYTNNAGVTYAPVIGDATDPNEGSSTGEPKSEQSNVAVRFGGSGTASDDIQSYSLVINKTDGDGQSVAGATYQLEDSTGTVLRTDLVTDSVGQLRIGNLSAGTYMLVETAAPSGYQIDTAKHVFTVSAAQATANVVTGSVVDKRIAKTALTVNKVWADVPAGVQTPTVEVTLQRNGQAYQTLQLTSANGYTGTFSDLDVTDVYGNAYTYTVIETAIAGYISSQTTSGETVTLTNTYQTGKLTVIKTDSSGANRLAGAVFAVKNAAGTLVAQLTTDATGQAQLTGLTQGAYTVSEIQAPDGYLINTQAQVLVLNEQSAYQGQLVFADEVEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPSEPVLPGHADEDSDSDQVVTTKTETAKLVKQTNLVTTTRPTKLLGQPIKLVATSKPVVKVTKATNRKSAQQLPQTSEQSMDWLMILGWFLLGLTVVSRQRRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT44</accession>
    <name>F9UT44_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0245"/>
    <dbReference type="EnsemblBacteria" id="CCC77775">
        <property type="protein sequence ID" value="CCC77775"/>
        <property type="gene ID" value="lp_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0245"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.202"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_4_2_9"/>
    <dbReference type="OMA" id="VHNEEGT"/>
    <dbReference type="PhylomeDB" id="F9UT44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-197-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="231" mass="26259" checksum="4AA688D425F6F812" modified="2011-10-19" version="1">METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLEKKSGIGTRVISNDLFNKLTQTQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTMLRIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKILQENGQTITHFQDKFSAVTLADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT63</accession>
    <name>F9UT63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641846.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77794">
        <property type="protein sequence ID" value="CCC77794"/>
        <property type="gene ID" value="lp_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="57027084"/>
    <dbReference type="GeneID" id="66448362"/>
    <dbReference type="KEGG" id="lpl:lp_0266"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.221"/>
    <dbReference type="eggNOG" id="ENOG5033XFD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208560_0_0_9"/>
    <dbReference type="OMA" id="QLAFNFT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-216-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="30001" checksum="B53D0499B981790E" modified="2011-10-19" version="1">MAKRRITHDPHQFVNTATDRRRLQLAVQLALPTCAHVLARNFARSSASSYWLLMLKTPGTAAPRFLTLRIADHLLWLTNHDQLTISWEAGNFDAVQRTLRQELTPATLQQYSYQLTTTDIMTLRLILHLEQHQLIWLVQLAPEIAKAYKNQHFDLRDDFGQAKLLLGNMNNSSLQLVPVKQPAFQNHLGQYFGRNLLFSQFTSHHLLRLLPTNQWIRPLLKVLPPTPNLEQQLAVLYGTDFVRIYVEAIRQQARLQAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB3</accession>
    <name>F9UTB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3206"/>
    <dbReference type="EnsemblBacteria" id="CCC80231">
        <property type="protein sequence ID" value="CCC80231"/>
        <property type="gene ID" value="lp_3206"/>
    </dbReference>
    <dbReference type="GeneID" id="57026494"/>
    <dbReference type="KEGG" id="lpl:lp_3206"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2679"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="FERYGKR"/>
    <dbReference type="PhylomeDB" id="F9UTB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2719-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="33469" checksum="96D2430F74EB750F" modified="2011-10-19" version="1">MANFAYEVFSTVVAQHTFYQAAATLNVTPSAVSHSINQLEKELGFPLFIRNRSGVELTSDGRQVLPYVQEILNTESNLRQVADNIQGLHSGSVRIGGFSSVCINWLPRIIREFNHKYPDIKISVMQGNFNEITNWAKIGTIDIGFTSMPVNENLLVHSLINDPIYCVTPADFIPENGEFITTDDVADKNFILQQSDYDRDTKLALDHYHVTNNFLRFSIDDQSIISMVESGLGMGILPQLALRKLTGDVNTFSFAEPYNREIALVANKTQAAAPSTAIMIRAIKQFLTKEYPDQMLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI7</accession>
    <name>F9UTI7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="3">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folB</name>
        <name evidence="5" type="ordered locus">lp_3299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890819.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTI7"/>
    <dbReference type="STRING" id="220668.lp_3299"/>
    <dbReference type="EnsemblBacteria" id="CCC80305">
        <property type="protein sequence ID" value="CCC80305"/>
        <property type="gene ID" value="lp_3299"/>
    </dbReference>
    <dbReference type="GeneID" id="57026567"/>
    <dbReference type="KEGG" id="lpl:lp_3299"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2755"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_1_4_9"/>
    <dbReference type="OMA" id="GHYKSVA"/>
    <dbReference type="PhylomeDB" id="F9UTI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2793-MON"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13817" checksum="319863DF571CE722" modified="2011-10-19" version="1">MGMIRINNLRFHTFNGVLPEERRNGQQLGLDIAIKYPIETKVQHDDVHETINYAAVRNVVDEFVTTHSYKLIESLANHLLQTLLTSFPAADAINIKIRKYSVPMPGIFDDVEIEVEGTPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK2</accession>
    <name>F9UTK2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase/esterase, SGNH or GDSL hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890834.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTK2"/>
    <dbReference type="EnsemblBacteria" id="CCC80320">
        <property type="protein sequence ID" value="CCC80320"/>
        <property type="gene ID" value="lp_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3323"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2771"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293037_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2811-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23107" checksum="FCF1A4E697D799F3" modified="2011-10-19" version="1">MAISNGHVSFKRPAWLGDSITANNGLATVHYHDILAADWDVERSDNLGISGSTIGSRYDAMAVRYQAIPEDADFIAVFGGVNDYGRDQPLGQYGDCDMTTFYGALMMLLTGLQTNWPTVPKLFISAIHIGSDFGGSFSAVTNGLGYRQSDYEAAIAQMTADYGVPHLSLYRDAGMTFAIPAQAAIYSVDTLHPNNAGHRVIARKLQSFLDSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP0</accession>
    <name>F9UTP0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888324.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0284"/>
    <dbReference type="EnsemblBacteria" id="CCC77810">
        <property type="protein sequence ID" value="CCC77810"/>
        <property type="gene ID" value="lp_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0284"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.238"/>
    <dbReference type="eggNOG" id="ENOG5030A31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2330228_0_0_9"/>
    <dbReference type="OMA" id="TCDLVMQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-232-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="10919" checksum="C191781DCD21AAD2" modified="2011-10-19" version="1">MSDMGLFRDAMQALYHSGHYGYNINVKKSAPAVDPKEVPAIAALGRINRTPNFKTWSVDSPYKTAEFTAKLTDAVATCDLEMQDLEIKPQIDGRWGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP3</accession>
    <name>F9UTP3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641862.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77813">
        <property type="protein sequence ID" value="CCC77813"/>
        <property type="gene ID" value="lp_0287"/>
    </dbReference>
    <dbReference type="GeneID" id="57027100"/>
    <dbReference type="KEGG" id="lpl:lp_0287"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.241"/>
    <dbReference type="eggNOG" id="ENOG5030A6C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2260205_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-235-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11902" checksum="CB0B84FC17219A48" modified="2011-10-19" version="1">MSQPNTLHPQAYCYYIELTGSERPDLLTALTTSEQELGDWEPVQAAKLPTWRLWTDANADTIRYTVAHVIARSALPQNAYWLLQYKGTDHGHPRMLHPQFHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ1</accession>
    <name>F9UTQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tag1</name>
        <name evidence="1" type="ordered locus">lp_0296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0296"/>
    <dbReference type="EnsemblBacteria" id="CCC77821">
        <property type="protein sequence ID" value="CCC77821"/>
        <property type="gene ID" value="lp_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="57027108"/>
    <dbReference type="KEGG" id="lpl:lp_0296"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.249"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_9"/>
    <dbReference type="OMA" id="MVDTHLV"/>
    <dbReference type="PhylomeDB" id="F9UTQ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-243-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="21460" checksum="F0F90E6884E27E20" modified="2011-10-19" version="1">MQRCAWADSSPAMQAYHDNEWGRPQHNQQRLFELLCLETYQAGLSWQTVLNKRAAFNEDFADYDVDQVAAMTTADVERLLTDARIIRHRQKLMATINNARVIRDWPAGEDFATWLWAFVDNQPIRQAWASIDEVPATNDLAQQVSKEMKRRGFKFVGPTTIYSYLQATGLINDHVVDCPFAPENLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY5</accession>
    <name>F9UTY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100992.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888419.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0394"/>
    <dbReference type="EnsemblBacteria" id="CCC77905">
        <property type="protein sequence ID" value="CCC77905"/>
        <property type="gene ID" value="lp_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0394"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.327"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_4_9"/>
    <dbReference type="OMA" id="NHARTEK"/>
    <dbReference type="PhylomeDB" id="F9UTY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-328-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="41434" checksum="08BF82E94F4E86F6" modified="2011-10-19" version="1">MQPRLTTTISILSLSTVTGITTVITGIIPQLKRTFPTVPTTLIEWLVTIANCSALITLLFNPRLTSRWGLRPIVISGLLISAIMGLIPAITTNFTVIMVSRLGLGLGVGLFSPHAISLLTHSFTGDLRARLLGYQTGLSALGNAILLGLAGLLISLSWHAVFWLYGLLVIVAGGVAWFVPEPTVPSTTTNHARTEKTQLPRHQWTLLGLTFITYLLIWGVQLKLPSYFSARHFGNAATINLTLAAMNIGGLLAGLTFGYLYRYLHRFTLTLGYAGAAISVLVLWLASNATVAIGAAVFFNFIYSYTGPYLVFTSNTGLDTIQVNVLSSYLTIATIISAFFAPLVWNSLGQLGPQTLTANVLIWIMLILGGLALITGSHHPRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
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    <name>F9UU01_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Plantaricin biosynthesis protein PlnQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnQ</name>
        <name evidence="2" type="ordered locus">lp_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888435.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0413"/>
    <dbReference type="EnsemblBacteria" id="CCC77921">
        <property type="protein sequence ID" value="CCC77921"/>
        <property type="gene ID" value="lp_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0413"/>
    <dbReference type="eggNOG" id="ENOG5030BD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2898611_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-343-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="62" mass="7253" checksum="5DC00B50EF9056E5" modified="2011-12-14" version="1">MKSYNMKLNRDFYKAYSFWLGVLAVIGLVGDVLLKYNTAVSPWIMILIAIYLFLRAFTSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU06</accession>
    <name>F9UU06_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin immunity protein PlnI,membrane-bound protease CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plnI</name>
        <name evidence="3" type="ordered locus">lp_0419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646470.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0419"/>
    <dbReference type="EnsemblBacteria" id="CCC77926">
        <property type="protein sequence ID" value="CCC77926"/>
        <property type="gene ID" value="lp_0419"/>
    </dbReference>
    <dbReference type="GeneID" id="57024222"/>
    <dbReference type="KEGG" id="lpl:lp_0419"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.342"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056865_0_0_9"/>
    <dbReference type="OMA" id="LRTRNIW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-348-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="28997" checksum="AC37A0CBC0DC34AF" modified="2011-12-14" version="1">MPLIKVIITAIYYLIVLFLMNPLTDIMGIKDGPFQFILTESIILIAIIILNRRYVKQPIHWLPVNIMSILKKNSLPLSLAIIFLLIFFRNHMYQFLISLLLSLIVAITEEYAFRGMIFRTLLALNLKKFATLQATIASMMTASLIFAAMHLVNLLSQPVWSVLCQVLYVIGLGILLAAIYLKTGSLLAAISVHWLIDFSSFYSQGIDPTQSPINGPMEALLKGLFLNILFIGIATFILSSKHWKLLSILNIEDKIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU19</accession>
    <name>F9UU19_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0433"/>
    <dbReference type="EnsemblBacteria" id="CCC77939">
        <property type="protein sequence ID" value="CCC77939"/>
        <property type="gene ID" value="lp_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0433"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.353"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_9"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="PhylomeDB" id="F9UU19"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-360-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="28978" checksum="C1424914D7649181" modified="2011-10-19" version="1">MHVALAQLNIQFGDPDANYEQIEMAIQRAAEQTVDVIVLPEMWNTGYALTRLNVLADDDGQRTLQLLSKLAQQFCVNIVGGSVAVARDGHYYNEMLVVDRQGQLLSRYDKVHRFGLMAEDRYITAGETENVFELDGTVAMGAICYDIRFPEWLRKQAARGPQVIFFSAEWPTVRQMQWRLLLQARAIENQAFVVAVNRVGSDPDNQFGGQSLVIDPLGQIVAIGGAHAQLITAELDLTQVDQVRGQIPVFEDRRPELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU26</accession>
    <name>F9UU26_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional protein: transcription regulator sugar kinase, ROK family</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0441"/>
    <dbReference type="EnsemblBacteria" id="CCC77946">
        <property type="protein sequence ID" value="CCC77946"/>
        <property type="gene ID" value="lp_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0441"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.361"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_9"/>
    <dbReference type="OMA" id="ANYDAHD"/>
    <dbReference type="PhylomeDB" id="F9UU26"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-367-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="31670" checksum="9842DFB498983456" modified="2011-10-19" version="1">MTMYIGIDIGGTSIKCGLVDAHGHISRKVTRPTATAKVDIMADLVAMIQGLQADGQVAGIGVSMPGVVQSDGFLTTAGAVTAFEKINLQAELHAQTQLPVIIENDANAAAIAEQWLGVAQNVPNYLSLVLGTGVGGALVINNQIYRGAHARSGEFGWMVVDDDEIDTEMGTLNFRGATVIGLIRRYNQFSAMPVTDAREIFDRADAGEVLAQHVFHSYYYSLAKGIINLMVAFDPELVVIGGGISANMTFMTDLNATIADLQANHNSINHLTLASVVPAKLRNDAGMIGAVYQLIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU56</accession>
    <name>F9UU56_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80358">
        <property type="protein sequence ID" value="CCC80358"/>
        <property type="gene ID" value="lp_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3372"/>
    <dbReference type="eggNOG" id="ENOG5030A51">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343179_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2846-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="97" mass="11394" checksum="38E1A0DFBE24811A" modified="2011-10-19" version="1">MNPEDMFQRYLNKYQITYQHPEHGLVMLTSPVWPQHPELQQAIQSAFQGLNGVTSITINSPEQLVMRYHSDQLRRLSPLTLLNLERQLSKQYHQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU61</accession>
    <name>F9UU61_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890877.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3378"/>
    <dbReference type="EnsemblBacteria" id="CCC80363">
        <property type="protein sequence ID" value="CCC80363"/>
        <property type="gene ID" value="lp_3378"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3378"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2815"/>
    <dbReference type="eggNOG" id="ENOG5030A7Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135554_0_0_9"/>
    <dbReference type="OMA" id="HIPDEHF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2851-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="15594" checksum="EB1FA718A72C2E27" modified="2011-10-19" version="1">MRVLYPKLVEEAYNYIAKAEPAVKNAPNAVKSEIYSKMVNDGIIDENGEPTQTAIDRGFVDGDSELDYEPATLAEFKAMHPCYKEYDDSHFSHTDQGWVIDSYVMKSLSLKALHDPNSSEEQRSFARHALEEIERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU67</accession>
    <name>F9UU67_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102137.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3384"/>
    <dbReference type="EnsemblBacteria" id="CCC80369">
        <property type="protein sequence ID" value="CCC80369"/>
        <property type="gene ID" value="lp_3384"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3384"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2820"/>
    <dbReference type="eggNOG" id="ENOG503019K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2700129_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2857-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="73" mass="8173" checksum="2B6C7CD0282B33CB" modified="2011-10-19" version="1">MNNAQTRLNHARTTLQGTLLQLDYLQELVNETAMQDSQRAKISQQIHNIEVNNQGALKQLASVYEVPLVGIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU76</accession>
    <name>F9UU76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface hydrolase, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3393"/>
    <dbReference type="ESTHER" id="lacpl-LP.3393">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.B04"/>
    <dbReference type="EnsemblBacteria" id="CCC80378">
        <property type="protein sequence ID" value="CCC80378"/>
        <property type="gene ID" value="lp_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3393"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2827"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_3_9"/>
    <dbReference type="OMA" id="LLWINTI"/>
    <dbReference type="PhylomeDB" id="F9UU76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2865-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="35468" checksum="647C7EF62938999E" modified="2011-10-19" version="1">MTTRKKWTIALIAFLTVIAIGVAGGSFYLYHFAFEPTPKVLNHSSSKSKSKLKQNQAWLKRVNKQTWHETSATDHLKLVADYVPAAHRTTKTIIVAHGYMGNKEQMASYIRLWHRQGYNVLAPDDRGNGQSQGDYYGFGWPDRLDYLKWTRQVIRRVGQNSQIGLFGVSMGGATVMMMSGEKLPSQVKAIIEDCGYTSVGDELGYELNQLYHLPKFPLLYTASWVAQAKAHFNFMTASSVNQLKKNKLPIFFIHGAKDTFVPTKMVYQNYRATTVKSKQLWVAPGAGHAESYTRYPQLYQQKVSQFMAKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU94</accession>
    <name>F9UU94_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890910.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3415"/>
    <dbReference type="DNASU" id="1063759"/>
    <dbReference type="EnsemblBacteria" id="CCC80396">
        <property type="protein sequence ID" value="CCC80396"/>
        <property type="gene ID" value="lp_3415"/>
    </dbReference>
    <dbReference type="GeneID" id="57026642"/>
    <dbReference type="KEGG" id="lpl:lp_3415"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2845"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132477_0_0_9"/>
    <dbReference type="OMA" id="YALEHIN"/>
    <dbReference type="PhylomeDB" id="F9UU94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2883-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="29277" checksum="20FFD211B4263697" modified="2011-10-19" version="1">MNFPELKLSQTERDFNFDFAILEHDLSYFFEKRCLDYALEHINRFNHKIKDNLYNVRPLILKEALISLTCDLASVSFYHYLNMITFVNLRKDILHYLTTTTLTNDDFMPLLESIVNNYFSNLDTLDIPIDGTRLSKQVALVVYYIDNHCDEPLRANTILEELTLDPEYTKRKFRKELGFTINFYIRHAKLQRAKQLLINTHLPIGEIAERINFYNSAEFARQFQKEFDITPSKYRELNQIFYKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC9</accession>
    <name>F9UUC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3459"/>
    <dbReference type="EnsemblBacteria" id="CCC80431">
        <property type="protein sequence ID" value="CCC80431"/>
        <property type="gene ID" value="lp_3459"/>
    </dbReference>
    <dbReference type="GeneID" id="57026677"/>
    <dbReference type="KEGG" id="lpl:lp_3459"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2879"/>
    <dbReference type="eggNOG" id="ENOG502ZI5S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316764_0_0_9"/>
    <dbReference type="OMA" id="KDEWESL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2919-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="99" mass="11569" checksum="3D761F9025223773" modified="2011-10-19" version="1">MGTPLNPDDMQSLLTHDRRYQRASAILTDQWQRIIADEDLAYRQQITIDDLQFAKALLASETLTSQFEFDHYAGVQRLRQHYGSQLTSSAQHWLVQKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE7</accession>
    <name>F9UUE7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE2</name>
        <name evidence="10" type="ordered locus">lp_3481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102181.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890963.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3481"/>
    <dbReference type="EnsemblBacteria" id="CCC80449">
        <property type="protein sequence ID" value="CCC80449"/>
        <property type="gene ID" value="lp_3481"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3481"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2897"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_9"/>
    <dbReference type="OMA" id="DGELGEW"/>
    <dbReference type="PhylomeDB" id="F9UUE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2937-MON"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="334" mass="36401" checksum="CE286009C0B653AC" modified="2011-10-19" version="1">MAVLVLGGAGYIGSHAVDRLVAKGYDVAVVDNLVTGHRAAVNEHARFYEGDVRDTAFMNTVFDQENVEGVIHFAAFSVVPESMKDPLKYFDNNTAGMVKLLKVMAKHDVKKIVFSSTAATYGEPKQVPIKESDPQVPTNPYGESKLAMEKIMHWSDVAYGIKFVALRYFNVAGAKPDGSIGEDHAPETHLVPIILQVAAGERDQLQIFGDDYPTPDGTNVRDYVHVVDLADAHILALEYLKQGHDSDAFNLGSSTGFSNKQMLDAAREVTGKPIPAVMAPRRAGDPSTLVAASDKARTVLGWTPQYDDVKEIIKTAWTWKESHPAGYDDRGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF8</accession>
    <name>F9UUF8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE3</name>
        <name evidence="11" type="ordered locus">lp_3492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890974.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3492"/>
    <dbReference type="EnsemblBacteria" id="CCC80460">
        <property type="protein sequence ID" value="CCC80460"/>
        <property type="gene ID" value="lp_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3492"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2908"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_0_9"/>
    <dbReference type="OMA" id="WRVGIQH"/>
    <dbReference type="PhylomeDB" id="F9UUF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2948-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="318" mass="35278" checksum="6489B3560A2F49BB" modified="2011-10-19" version="1">MIGTQKKYVSQFTMMGTVISLTLFEPNQLAVEAVYDYLQRMDGVFSVNRADSELAAINQYAGIHPVLVSTECFQLVSDAIKYTKQYADSFNVLIGPLVKLWKIGFGGHQVPAAKGISQRLALLDTHEVILDEAQSSIYLRQSGMQLDLGAIAKGYFADQVVKQLQQAGITNAIVNLGGNVKLLGANPLTDNRRWQVGIQAPEAPRGYPALQVEMPARTVVTSGIFERYFKIGNHRYHHILDPRTGYPVENQVDQVSIITERSELAEVLSTVAYFEGPNRGCQLIEQLPHTEAIFIDHEQQVTVTSGLTPRRKGVFTIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O08321</accession>
    <accession>F9UL06</accession>
    <name>ARGD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylornithine aminotransferase</fullName>
            <shortName evidence="1">ACOAT</shortName>
            <ecNumber evidence="1">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argD</name>
        <name type="ordered locus">lp_0531</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="1"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101045.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888535.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08321"/>
    <dbReference type="SMR" id="O08321"/>
    <dbReference type="STRING" id="220668.lp_0531"/>
    <dbReference type="EnsemblBacteria" id="CCC78021">
        <property type="protein sequence ID" value="CCC78021"/>
        <property type="gene ID" value="lp_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0531"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.439"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_9"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="PhylomeDB" id="O08321"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-442-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112749" description="Acetylornithine aminotransferase">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68242." evidence="2" ref="1">
        <original>C</original>
        <variation>R</variation>
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68242." evidence="2" ref="1">
        <original>P</original>
        <variation>T</variation>
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="389" mass="41459" checksum="428AEA97EA37C9C4" modified="2011-11-16" version="4">MTMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQLTHIWHTSNLYENELQDAVAGLLANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQHSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAALDKITPELAAVILEVVQGEGGVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLANGLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQSLATQVEPIPVVKQITGKGLMIGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPIVMQPADLLAGIALIAKVLTTLTTEVTTNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O08322</accession>
    <accession>F9UL07</accession>
    <name>OTC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Ornithine carbamoyltransferase</fullName>
            <shortName>OTCase</shortName>
            <ecNumber>2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">argF</name>
        <name type="ordered locus">lp_0532</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101046.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888536.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08322"/>
    <dbReference type="SMR" id="O08322"/>
    <dbReference type="STRING" id="220668.lp_0532"/>
    <dbReference type="EnsemblBacteria" id="CCC78022">
        <property type="protein sequence ID" value="CCC78022"/>
        <property type="gene ID" value="lp_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0532"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.440"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_1_9"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="PhylomeDB" id="O08322"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-443-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112937" description="Ornithine carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68243." evidence="3" ref="1">
        <original>C</original>
        <variation>G</variation>
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68243." evidence="3" ref="1">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68243." evidence="3" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68243." evidence="3" ref="1">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="340" mass="36974" checksum="59BF46086D5620E9" modified="2003-03-25" version="2">MNNQFEGRSFLKEIDYTPTELAYLIDFASHLKTLKAHHIPHPYLQGKNIALLFEKTSTRTRSAFTVAANDLGANPEFLCKDDIQFGTKESVVDTAKVLGSMYDGIEFRGFKQSTVEDLATYSGVPVWNGLTDEWHPTQILADFLTLKEHFGHLKGLTLAYVGDGRNNMANSLLVAGAMLGINIAIGSPVALQPAPAVVALAQQYAQAAGSTVVITADPQQAVTQADALYTDVWVSMGEQVDYGERIKQLLPFQINTALLAATGKSSTIVMHCLPALHDLKTQLGAKLGEQYGMTAFEITDDVFQSKQEVVFEEAGNRMPAIKAVMAATLGNLFIPTSIFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>P59390</accession>
    <accession>F9UMR3</accession>
    <name>LDH2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase 2</fullName>
            <shortName evidence="1">L-LDH 2</shortName>
            <ecNumber evidence="1">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ldh2</name>
        <name type="synonym">ldhL2</name>
        <name type="ordered locus">lp_1101</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889016.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59390"/>
    <dbReference type="SMR" id="P59390"/>
    <dbReference type="STRING" id="220668.lp_1101"/>
    <dbReference type="EnsemblBacteria" id="CCC78502">
        <property type="protein sequence ID" value="CCC78502"/>
        <property type="gene ID" value="lp_1101"/>
    </dbReference>
    <dbReference type="GeneID" id="57024748"/>
    <dbReference type="KEGG" id="lpl:lp_1101"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.931"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_9"/>
    <dbReference type="OMA" id="AWSHVTI"/>
    <dbReference type="PhylomeDB" id="P59390"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-945-MON"/>
    <dbReference type="BRENDA" id="1.1.1.27">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000168358" description="L-lactate dehydrogenase 2">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="309" mass="33116" checksum="A0DF444AC833060D" modified="2003-03-25" version="1">MDKKQRKVVIVGDGSVGSSFAFSLVQNCALDELVIVDLVKTHAEGDVKDLEDVAAFTNATNIHTGEYADARDADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFNGCFVISSNPVDILTSMTQRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEHGDSSIVNFDEIMINAQPLKTVTTVDDQFKAEIEQAVRGKGGQIISQKGATFYGVAVSLMQICRAILNDENAELIVSAALSGQYGINDLYLGSPAIINRNGLQKVIEAELSDDERARMQHFAAKMLTMMNVAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>P71478</accession>
    <accession>F9UMW0</accession>
    <name>CSP1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Cold shock protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">csp</name>
        <name type="synonym">cspP</name>
        <name type="ordered locus">lp_1160</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="3039" last="3042">
            <title>Cloning and characterization of cspL and cspP, two cold-inducible genes from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Mayo B."/>
                <person name="Derzelle S."/>
                <person name="Fernandez M."/>
                <person name="Leonard C."/>
                <person name="Ferain T."/>
                <person name="Hols P."/>
                <person name="Suarez J.E."/>
                <person name="Delcour J."/>
            </authorList>
            <dbReference type="PubMed" id="9139925"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>C38</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>In response to low temperature.</text>
    </comment>
    <dbReference type="EMBL" id="Y08760">
        <property type="protein sequence ID" value="CAA70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889063.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P71478"/>
    <dbReference type="SMR" id="P71478"/>
    <dbReference type="STRING" id="220668.lp_1160"/>
    <dbReference type="EnsemblBacteria" id="CCC78549">
        <property type="protein sequence ID" value="CCC78549"/>
        <property type="gene ID" value="lp_1160"/>
    </dbReference>
    <dbReference type="GeneID" id="49393431"/>
    <dbReference type="GeneID" id="57024795"/>
    <dbReference type="GeneID" id="66449050"/>
    <dbReference type="KEGG" id="lpl:lp_1160"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.980"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_9"/>
    <dbReference type="OMA" id="ICEMAKI"/>
    <dbReference type="PhylomeDB" id="P71478"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-991-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000100305" description="Cold shock protein 1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CSD">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="66" mass="7257" checksum="923A44CD6DBD2EA9" modified="1997-02-01" version="1">MKNGTVKWFNADKGYGFITGEDGNDVFVHFSAIQTDGFKTLEEGQKVTFDEESSDRGPQAANVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG3</accession>
    <name>Q6LWG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf14</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003678453.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133728.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723564"/>
    <dbReference type="EnsemblBacteria" id="CAG17845">
        <property type="protein sequence ID" value="CAG17845"/>
        <property type="gene ID" value="CAG17845"/>
    </dbReference>
    <dbReference type="GeneID" id="57295601"/>
    <dbReference type="KEGG" id="lpl:CAG17845"/>
    <dbReference type="eggNOG" id="ENOG5030BJ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180510_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3145-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12780" checksum="E6C00C712CE84BAD" modified="2004-07-05" version="1">MMQTEYAQQDSLANRLNIVDALVKQATKAEIESISAVYLIQANQEINLLELKYSSELTIQQNLYKVKIAFLQINHLILNNLAVSYFRDYTQIEKEFEHFHRLICEVKDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V05</accession>
    <accession>F9UQK1</accession>
    <name>TGT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgt</name>
        <name type="ordered locus">lp_2282</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V05"/>
    <dbReference type="SMR" id="Q88V05"/>
    <dbReference type="STRING" id="220668.lp_2282"/>
    <dbReference type="EnsemblBacteria" id="CCC79490">
        <property type="protein sequence ID" value="CCC79490"/>
        <property type="gene ID" value="lp_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2282"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1932"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_9"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="PhylomeDB" id="Q88V05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1974-MON"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000135487" description="Queuine tRNA-ribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="1">
        <location>
            <begin position="250"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="1">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <sequence length="380" mass="42830" checksum="E22D69B656C308A4" modified="2003-06-01" version="1">MEPAIKYRLIKKEKHTGARLGELITPHGTFPTPMFMPVGTQASVKSLAPEELDAMGAGVILSNTYHLWLRPGEQIVKEAGGLHQFMNWKKGILTDSGGFQVFSLAKNRDITEEGVHFKNHLNGSKMFLSPEKAIQIENDLGPDIMMSLDECPPFFESYDYVSKSVARTSRWAERGLKVHQHPDYQGLFGIVQGAGFKDLREQSAKDLVSLDFPGYSIGGLSVGESKAEMNHVLDFTTPLLPENKPRYLMGVGSADALIDGAIRGVDMFDCVLPTRIARNGTCMTSHGRLVVKNAAYAHDFTPLDDNCDCYTCRNFTRAYIRHLIKADETFGLRLTSYHNLYFLLHLMKQVRQAIMDDNLLEFRQNFFEMYGFNDKNPKNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V14</accession>
    <accession>F9UQJ2</accession>
    <name>Y2273_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0473 protein lp_2273</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2273</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889995.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V14"/>
    <dbReference type="SMR" id="Q88V14"/>
    <dbReference type="STRING" id="220668.lp_2273"/>
    <dbReference type="EnsemblBacteria" id="CCC79481">
        <property type="protein sequence ID" value="CCC79481"/>
        <property type="gene ID" value="lp_2273"/>
    </dbReference>
    <dbReference type="GeneID" id="57025818"/>
    <dbReference type="GeneID" id="66450030"/>
    <dbReference type="KEGG" id="lpl:lp_2273"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1924"/>
    <dbReference type="eggNOG" id="COG3906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146610_2_1_9"/>
    <dbReference type="OMA" id="EVYAFRY"/>
    <dbReference type="PhylomeDB" id="Q88V14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1966-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01448">
        <property type="entry name" value="UPF0473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40066">
        <property type="entry name" value="PTHR40066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000304839" description="UPF0473 protein lp_2273">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01448"/>
        </source>
    </evidence>
    <sequence length="98" mass="11102" checksum="A0901DBF214ED49F" modified="2003-06-01" version="1">MSQNQDRKDNDVITLVDDEGNETLFNILFTFDSEDFGHSYILLYPADAAADDEVDIQAYIFNPEDGDNGELQLIESDDEWDMVEQVLNTFLADDGGMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V81</accession>
    <accession>F9UQC6</accession>
    <name>MURG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">lp_2196</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:23192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60032"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640857.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V81"/>
    <dbReference type="SMR" id="Q88V81"/>
    <dbReference type="STRING" id="220668.lp_2196"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79415">
        <property type="protein sequence ID" value="CCC79415"/>
        <property type="gene ID" value="lp_2196"/>
    </dbReference>
    <dbReference type="GeneID" id="57025724"/>
    <dbReference type="KEGG" id="lpl:lp_2196"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1856"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_9"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="PhylomeDB" id="Q88V81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1876-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109182" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="363" mass="38705" checksum="4AF96BFDE8CD050B" modified="2003-06-01" version="1">MRLMISGGGTGGHIYPALALIDALKAHDPEAQVQFVGTHRGLESRIVPERGIDFKTIKIQGFKRSLSLQNVKTVYLFLKSVVTARKYIKAFKPDVVVGTGGYVSGAVVFAASQMHIPTVIHEQNSVVGVTNKFLSRFVDKIAISFESARSQFPAQKVVMTGNPRAQQVANIKKSGALAQFDLDPDIPTALIFGGSRGAARINAAAVAAIPELNKRDYQTLFVTGQVHYEKIRNGLSATALAPNVKIEPYIKNMPAILPEVAVILGRAGATSIAEITALGIPSILVPSPYVTNDHQTKNAQSLVNAGAAELIKEADLTGTSLVAALDGLLQSTTHRETMAANAKKLGMPDAADQLLHVLETVIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VC8</accession>
    <accession>F9UQ77</accession>
    <name>COAD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="synonym">kdtB</name>
        <name type="ordered locus">lp_2133</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640809.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VC8"/>
    <dbReference type="SMR" id="Q88VC8"/>
    <dbReference type="STRING" id="220668.lp_2133"/>
    <dbReference type="EnsemblBacteria" id="CCC79366">
        <property type="protein sequence ID" value="CCC79366"/>
        <property type="gene ID" value="lp_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2133"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1807"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_1_1_9"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="PhylomeDB" id="Q88VC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1827-MON"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156223" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="163" mass="18072" checksum="439F3D6506DD3B4C" modified="2003-06-06" version="1">MVTAVFPGSFDPITRGHLDMIQRASRLVDRLIVAVMVNTSKQPLFTMTEKVAMISDELTGLPNVEVQAATGLTVDFMASVHATVLVRGLRNEQDFGYERDIAWMNKSLDETIETICLIARPPYAYFSSSLIKEVAKMGADVSKYVPTAVAQKLHQRLGTDQHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VE0</accession>
    <accession>F9UQ65</accession>
    <name>EFTU_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">lp_2119</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640798.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889868.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VE0"/>
    <dbReference type="SMR" id="Q88VE0"/>
    <dbReference type="STRING" id="220668.lp_2119"/>
    <dbReference type="EnsemblBacteria" id="CCC79354">
        <property type="protein sequence ID" value="CCC79354"/>
        <property type="gene ID" value="lp_2119"/>
    </dbReference>
    <dbReference type="GeneID" id="57025660"/>
    <dbReference type="GeneID" id="66449889"/>
    <dbReference type="KEGG" id="lpl:lp_2119"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1795"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_9"/>
    <dbReference type="OMA" id="ERPHCNV"/>
    <dbReference type="PhylomeDB" id="Q88VE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1815-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_TR_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
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    <dbReference type="Pfam" id="PF00009">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
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    </dbReference>
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        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091337" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="395" mass="43377" checksum="6563E3620B8C06EA" modified="2003-06-01" version="1">MAKEHYERTKPHVNIGTIGHVDHGKTTLTAAITKVLASKGLAKEQDFASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVDYIVVFLNKTDLVDDDELVDLVEMEVRELLSEYDFPGDDIPVIRGSALKALEGDPEQEKVIMHLMDVVDEYIPTPVRDTEKPFLMPVEDVFSITGRGTVASGRIDRGTVKVGDEVEIVGLHEDVLKSTVTGLEMFRKTLDLGEAGDNVGALLRGVNREQVVRGQVLAKPGSIQTHKKFKGEVYILSKEEGGRHTPFFSNYRPQFYFHTTDITGVIELPDGVEMVMPGDNVTFTVELIQPAAIEKGTKFTVREGGHTVGAGVVSEIDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W46</accession>
    <accession>F9UPF9</accession>
    <name>TARI_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribitol-5-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tarI</name>
        <name type="ordered locus">lp_1816</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12456"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57608"/>
            <dbReference type="ChEBI" id="CHEBI:57695"/>
            <dbReference type="EC" id="2.7.7.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.40" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889612.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W46"/>
    <dbReference type="SMR" id="Q88W46"/>
    <dbReference type="STRING" id="220668.lp_1816"/>
    <dbReference type="EnsemblBacteria" id="CCC79098">
        <property type="protein sequence ID" value="CCC79098"/>
        <property type="gene ID" value="lp_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1816"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1534"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_3_9"/>
    <dbReference type="OMA" id="TDACKIL"/>
    <dbReference type="PhylomeDB" id="Q88W46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1561-MON"/>
    <dbReference type="UniPathway" id="UPA00790"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047349">
        <property type="term" value="F:D-ribitol-5-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902012">
        <property type="term" value="P:poly(ribitol phosphate) teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TarI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="TarI"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000075580" description="Ribitol-5-phosphate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions ribitol 5-phosphate for the nucleophilic attack" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Positions ribitol 5-phosphate for the nucleophilic attack" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02068"/>
        </source>
    </evidence>
    <sequence length="233" mass="25901" checksum="6A576C790713C0D7" modified="2003-06-01" version="1">MIYAQILAGGKGTRMGNVPMPKQFLLLADKPILIHTIEKFTLESRFDAILVVCPADWVSHTEDIIKKYITDERVHVVVGGADRNETLMSGINYIQDHYGIQDDDVVVTHDAVRPFITQRIINDNIVAVLENKAVDTVVPAIDTIVRGANDQVTDIPVRSEMYQGQTPQSFHIKILIDSYNALSSEQKASLSDSCKICSLAGQKVSLVRGENYNFKITTPFDLRVASALVEKRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WK6</accession>
    <accession>F9UNZ7</accession>
    <name>RL28_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">lp_1624</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638622.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889450.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WK6"/>
    <dbReference type="SMR" id="Q88WK6"/>
    <dbReference type="STRING" id="220668.lp_1624"/>
    <dbReference type="EnsemblBacteria" id="CCC78936">
        <property type="protein sequence ID" value="CCC78936"/>
        <property type="gene ID" value="lp_1624"/>
    </dbReference>
    <dbReference type="GeneID" id="49393891"/>
    <dbReference type="GeneID" id="57025207"/>
    <dbReference type="GeneID" id="66449506"/>
    <dbReference type="KEGG" id="lpl:lp_1624"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1372"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_1_9"/>
    <dbReference type="OMA" id="QKVRIMV"/>
    <dbReference type="PhylomeDB" id="Q88WK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1399-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178488" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="61" mass="7001" checksum="F26AB1618D5396AD" modified="2003-06-01" version="1">MAKDYVTGKRTHFGNTRSHALNHSRRSWKANLQKVRILVDGKPKKVWVSARTLKSGKVTRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XG4</accession>
    <accession>F9UN34</accession>
    <name>Y1241_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0374 protein lp_1241</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1241</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0374 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889137.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XG4"/>
    <dbReference type="SMR" id="Q88XG4"/>
    <dbReference type="STRING" id="220668.lp_1241"/>
    <dbReference type="EnsemblBacteria" id="CCC78623">
        <property type="protein sequence ID" value="CCC78623"/>
        <property type="gene ID" value="lp_1241"/>
    </dbReference>
    <dbReference type="GeneID" id="57024863"/>
    <dbReference type="GeneID" id="66449120"/>
    <dbReference type="KEGG" id="lpl:lp_1241"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1053"/>
    <dbReference type="eggNOG" id="COG3557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109787_1_0_9"/>
    <dbReference type="OMA" id="QSYKHNG"/>
    <dbReference type="PhylomeDB" id="Q88XG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1064-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01568">
        <property type="entry name" value="UPF0374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016882">
        <property type="entry name" value="UPF0374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028345">
        <property type="entry name" value="UCP028345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248097" description="UPF0374 protein lp_1241">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01568"/>
        </source>
    </evidence>
    <sequence length="182" mass="21649" checksum="0A62F609DFD4C259" modified="2003-06-01" version="1">MAREAKGPKEGDFITIKSYKHDGSLHRTWRDTMVLKTSENVLIGCNDHTLVTEDDGRRWVTREPAIVYFHKHYWFNIVAMIRDNGVSYYCNLASPYVLDKEALKYIDYDLDVKVFPDGERRLLDVDEYEEHGAQWRYSADTDRILKANVKVLVDWIKNKKGPFSQDYIDIWYSRYQELSRRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW8</accession>
    <accession>F9UMM3</accession>
    <name>RL30_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">lp_1054</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641261.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW8"/>
    <dbReference type="SMR" id="Q88XW8"/>
    <dbReference type="STRING" id="220668.lp_1054"/>
    <dbReference type="EnsemblBacteria" id="CCC78462">
        <property type="protein sequence ID" value="CCC78462"/>
        <property type="gene ID" value="lp_1054"/>
    </dbReference>
    <dbReference type="GeneID" id="57024709"/>
    <dbReference type="GeneID" id="66448965"/>
    <dbReference type="KEGG" id="lpl:lp_1054"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.889"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_1_9"/>
    <dbReference type="OMA" id="ALFQIAH"/>
    <dbReference type="PhylomeDB" id="Q88XW8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-905-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000056057" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="60" mass="6681" checksum="5289720899643CC7" modified="2003-06-01" version="1">MAQLKITLVRSAAHRLPKQRKIVKELGLGRINSSVVKPDDAATRGQIFHIAHLVDVEIIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YE8</accession>
    <accession>F9UM39</accession>
    <name>GLMM_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="1">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmM</name>
        <name type="ordered locus">lp_0820</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888792.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YE8"/>
    <dbReference type="SMR" id="Q88YE8"/>
    <dbReference type="STRING" id="220668.lp_0820"/>
    <dbReference type="EnsemblBacteria" id="CCC78278">
        <property type="protein sequence ID" value="CCC78278"/>
        <property type="gene ID" value="lp_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0820"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.695"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_9"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="PhylomeDB" id="Q88YE8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-714-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147904" description="Phosphoglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <sequence length="451" mass="48376" checksum="F8E0C52BAB762F82" modified="2003-06-01" version="1">MKYFGTDGVRGIANSGLTPEMAFRLGRAGGYVLTEHAENKSTQPRVLVARDTRISGQMLEEALIAGLLSAGIEVLRLGVITTPGVAYLVRIQDADAGVMISASHNPVEDNGIKFFGGDGFKLSDAKEEEIEELLDQPKDTLPRPAAEGLGTVADFPEGNLKYSQFLEQTIPDDLSGIHLAVDGANGSTSNLVSRIFADLNVEFDTMATAPDGLNINKGVGSTHPEALSKFVVEKGAQVGLAFDGDGDRCIAVDELGNIIDGDKIMYICGKFLSERGKLKQDTVVTTVMSNLGLYKALEAAGLHSKQTQVGDRYVVEEMLKDGYNLGGEQSGHVVFLDFNTTGDGMLTGIQLLHVMKETGKKLSELAAEVTTYPQKLVNVKVQDKKAALNNDKIKAVIKDVEDEMAGDGRVLVRPSGTQDLLRVMAEAKTDELVSAYVDRIVDVVKAEVGIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YF4</accession>
    <accession>F9UM33</accession>
    <name>MURB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="1">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murB</name>
        <name type="ordered locus">lp_0814</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888786.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YF4"/>
    <dbReference type="SMR" id="Q88YF4"/>
    <dbReference type="STRING" id="220668.lp_0814"/>
    <dbReference type="EnsemblBacteria" id="CCC78272">
        <property type="protein sequence ID" value="CCC78272"/>
        <property type="gene ID" value="lp_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="57024513"/>
    <dbReference type="KEGG" id="lpl:lp_0814"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.689"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_9"/>
    <dbReference type="PhylomeDB" id="Q88YF4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-708-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179221" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <sequence length="302" mass="32333" checksum="304D11368BB4FBC5" modified="2011-11-16" version="2">MTKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVAFPKSISETKALITFANEQNLPLTVIGNASNLIVKDGGIRGLTIILTRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFAAGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKTLDHDELDFGYRHSTIQDYDDIVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGLQGHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL33</accession>
    <name>F9UL33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA</name>
        <name evidence="9" type="ordered locus">lp_0562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0562"/>
    <dbReference type="EnsemblBacteria" id="CCC78048">
        <property type="protein sequence ID" value="CCC78048"/>
        <property type="gene ID" value="lp_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="57024343"/>
    <dbReference type="GeneID" id="66448615"/>
    <dbReference type="KEGG" id="lpl:lp_0562"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.466"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_9"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="PhylomeDB" id="F9UL33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-478-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="52"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="378" mass="41403" checksum="21CAAAFCED51B3AD" modified="2011-10-19" version="1">MSKVLKHAIIYTGLEKIDDGYIRFGKEIEAVGPMDDYVAQPDDDIEFVSGKTIVPGFIDVHSHGGYSFDSMDGNPAEINEMVNDMVAREGITSYFCTTMTQSNENLDHSMAGINKAADENPVIQGVHLEGPFISATFKGAQPEKYIKNPNVDLLDNWNKLSGGRVKLITYAPEDPGSREFEKYCLENGIVPSVGHSNATREQLLASKATHVTHLYNAQREFKHREPGVTGHAMLENNMYCELICDGFHIVPDMIKLAYEQKGVDRIELVTDSMRAKGEPDGISELGGQKVIVKDGQARLEEGNLAGSVLTFINAFKNIQKFTGCGIAEAVKMASVNQAREFGLTKKGTLEAGKDADINILDGNQDLVATYSYGKKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_0618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888612.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0618"/>
    <dbReference type="ESTHER" id="lacpl-LP.0618">
        <property type="family name" value="Duf_915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78098">
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        <property type="gene ID" value="lp_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0618"/>
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    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_0_0_9"/>
    <dbReference type="OMA" id="HSYGGTE"/>
    <dbReference type="PhylomeDB" id="F9UL83"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-529-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="32488" checksum="6D9F4B165FB28D4B" modified="2011-10-19" version="1">MAEVILVIIGALVLGILGRITFKFWQYGRPQHLRQSVSANSADDSAVTLFIPGYAGNRFSFGGMLQRFTAGGIANKSLVVMIDRHNHPHVTGELDAYRPMVQLIFATPRVAVRQQAAGVLAVVQYLIAHEHVQTINLVAHSMGGVVLFQYLTTAAKLVNLPEVRKVVTIGAPFNDSEVGQNTYPIENHPLTATGPTKTTPVYNYFLRTLQRLPNTISYLNIAGNIGDAAQSDGAVALNSALSLRFLLRPTRDQYQEFVVHGKNARHSRLHENYEVDRQIVQFFISRSHKKGCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB6</accession>
    <name>F9ULB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3560"/>
    <dbReference type="EnsemblBacteria" id="CCC80523">
        <property type="protein sequence ID" value="CCC80523"/>
        <property type="gene ID" value="lp_3560"/>
    </dbReference>
    <dbReference type="GeneID" id="57026759"/>
    <dbReference type="KEGG" id="lpl:lp_3560"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2970"/>
    <dbReference type="eggNOG" id="COG5506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111531_0_1_9"/>
    <dbReference type="OMA" id="VESKYHE"/>
    <dbReference type="PhylomeDB" id="F9ULB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3011-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012543">
        <property type="entry name" value="DUF1694"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07997">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034303">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="15913" checksum="E128F965D82A59D1" modified="2011-10-19" version="1">MQDNEEVLGTRLQNGMFGVPDLHPDEQHRYLGTFYERVELQISFKQALRYDFTSVLVPVLRQPRDYQLLLNGQLDMDIMGRYMRLANQYSILFTVKNSHFYHHNLDSAAIILCADHALNRTEVDILQRYPQIAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC5</accession>
    <name>F9ULC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891046.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3570"/>
    <dbReference type="EnsemblBacteria" id="CCC80532">
        <property type="protein sequence ID" value="CCC80532"/>
        <property type="gene ID" value="lp_3570"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3570"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_2_1_9"/>
    <dbReference type="OMA" id="RYGPWAT"/>
    <dbReference type="PhylomeDB" id="F9ULC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3020-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="16182" checksum="0E0B54510D4EBEF7" modified="2011-10-19" version="1">MTTPKRYELEDAQWDRIKGYFPPYRTGRPSSLDNRTALNAILWLMRSGAPWRDLPERYGSWKTVYSRFRAWVSSGLFEQVFLELIDDPDMENLSLDSTIVRAHQKATGAKKRRMYGRKSSYWIKSRWPNDQDSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF5</accession>
    <name>F9ULF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system, galactitol-specific EIIC component</fullName>
            <ecNumber evidence="12">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pts36C</name>
        <name evidence="12" type="ordered locus">lp_3601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102243.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891076.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3601"/>
    <dbReference type="EnsemblBacteria" id="CCC80562">
        <property type="protein sequence ID" value="CCC80562"/>
        <property type="gene ID" value="lp_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3601"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3006"/>
    <dbReference type="eggNOG" id="COG3775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040393_1_0_9"/>
    <dbReference type="OMA" id="FLMPIDW"/>
    <dbReference type="PhylomeDB" id="F9ULF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3049-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015577">
        <property type="term" value="F:galactitol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013853">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37324">
        <property type="entry name" value="PTHR37324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006304">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="11">
        <location>
            <begin position="8"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="516" mass="56393" checksum="9F3DBA7D72CB8D2C" modified="2011-10-19" version="1">MDVLKTIVNYVLNLGGPVFVPLIMFIIATIAGLKLKKSVLAALTLGVAFSGMTLVVNYMMDSISPAAKAMSKIFHLSLNAIDAGWTGVAAITWSYKSAFLFFPLLLAINFIMLTFKWTKTLNVDMWNVWNKIFTYVVVLYFTHNVFYGFIVAGIQIVLELKAGDMWQRHIEDLTGMPGVTVPHFVTLFAVILQPLNKLLDFIPAMNRPFDSAALQKKIGVFGDNTVMGAIIGVLLGFGAGYSVSKSLNLAIQAATAMTLFPMISKLFMQALSPIADAMSDFMKKHFNGREVFIGLDWPILAGRNELWVTVVILVPVMLVFAMLLPGNTVLPFAGIINLSFVVAALLLTGANLLRMLVLGIITTPIFLYGATYFAPIITNLAKSTGTVKVQAGQQLSWSTFEGPDFRLFFAKAFTGEWWAIGISILWLLGFIWLYIDQNKIKLPSQRYVLAGSAQSSSTTAAPSETTTTSAGSLDDLDDMDFSNTSKSSASNNATKVSLNDLDGLNFSNTSKHNNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI2</accession>
    <name>F9ULI2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102270.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891103.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3633"/>
    <dbReference type="EnsemblBacteria" id="CCC80589">
        <property type="protein sequence ID" value="CCC80589"/>
        <property type="gene ID" value="lp_3633"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3633"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3033"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_9"/>
    <dbReference type="OMA" id="CRRIMFV"/>
    <dbReference type="PhylomeDB" id="F9ULI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3076-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="354" mass="39377" checksum="200A6ABEFDEC92A9" modified="2011-10-19" version="1">MPKSEPRYLTIYNQLKNQITSGTLTANEQLPTELQLAKAYNVSRITSKRALTELESQGLIYRKQGSGSFVQPTDQPKTNKQLLLVLPFPTDAGLGDYASGVSLAASAHHYQAVTMDSASFFNLSAKEIHENYAGVIYLPQDLYQEAERIYQLKLAQVPVVILDKTLPALELPVVTADNFSGGQIATDHLLQLGHQQILFYAQRNNTVLPSSVYERYFGYLTALNQQHVTPVTALADLPTLNQFSTNDWLTYLADHQITAIVVENDLTAIKLMNTLRKVDPKIWQRLSIVGFDNIQAASLTYPSLTTVAQDFKGMGTKAVSLLLKTPVQPTTVRLPVQLIQRDSTQPFQPISKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL5</accession>
    <name>F9ULL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3669"/>
    <dbReference type="EnsemblBacteria" id="CCC80622">
        <property type="protein sequence ID" value="CCC80622"/>
        <property type="gene ID" value="lp_3669"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3669"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3066"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_1_9"/>
    <dbReference type="OMA" id="IWARDWE"/>
    <dbReference type="PhylomeDB" id="F9ULL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3109-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="31792" checksum="4B6D09947C6FAB35" modified="2011-10-19" version="1">MKTAIVTDSASYLSAADVEKYHIHVVPITVIFGHQTYLENVEITSKEFYERMRTAPELPTTTQITLGQMQTTYDQLAKAGYDAVISIHLSSGITSFITNLESYLPNVTNIKVYPFDSLITAGGEAYMVLLAAKLVTEGYSPEQVIAQLKKIRETTGVYFVVDNLSHLVRTGRLSNASGLVGNLLRIKPVLTFQDGKIVAIQKERTMRRAYAAIKAKLAAEIAAVDYPLRVTIENGNNPKLQAEWTADLKASFPDLTIDEGEIGPVVGVHVGEGVMGLIWARDWEKWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT4</accession>
    <name>F9ULT4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">dnaX</name>
        <name evidence="7" type="ordered locus">lp_0698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101139.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888687.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0698"/>
    <dbReference type="EnsemblBacteria" id="CCC78173">
        <property type="protein sequence ID" value="CCC78173"/>
        <property type="gene ID" value="lp_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0698"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.586"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_3_9"/>
    <dbReference type="OMA" id="EIHCKMV"/>
    <dbReference type="PhylomeDB" id="F9ULT4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-608-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpA/B"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
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        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="565" mass="62752" checksum="D7B481C2B146C71B" modified="2011-10-19" version="1">MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKAINCHHLVDGEPCNECETCTAITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYKVYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHKIPLTIISRTQRFDFRRITAKDSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVTGSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEMVDSVAMGEDDQQFEAFAKQIDAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLDGQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQGGSITKPAPAKPRSSNGPVVKKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFDYAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQQAPAKEPVVEEAKNMFGDLVEVQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT7</accession>
    <name>F9ULT7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888690.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0701"/>
    <dbReference type="EnsemblBacteria" id="CCC78176">
        <property type="protein sequence ID" value="CCC78176"/>
        <property type="gene ID" value="lp_0701"/>
    </dbReference>
    <dbReference type="GeneID" id="57024411"/>
    <dbReference type="GeneID" id="66448679"/>
    <dbReference type="KEGG" id="lpl:lp_0701"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.589"/>
    <dbReference type="eggNOG" id="ENOG5033B6J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187598_0_1_9"/>
    <dbReference type="OMA" id="AKIDWDT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-611-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019644">
        <property type="entry name" value="DUF2508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10704">
        <property type="entry name" value="DUF2508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9849" checksum="DFD01900647F1223" modified="2011-10-19" version="1">MFKRKQKIKHPKEVFDEQLLSTLNAAKLDWDRAKQNQEAVYDNNTSELVTQTALARAKYLYLYREARLRQVHGQTIQRSVIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM60</accession>
    <name>F9UM60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888813.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0845"/>
    <dbReference type="DNASU" id="1061992"/>
    <dbReference type="EnsemblBacteria" id="CCC78299">
        <property type="protein sequence ID" value="CCC78299"/>
        <property type="gene ID" value="lp_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0845"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.719"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_9_0_9"/>
    <dbReference type="OMA" id="GAITQVC"/>
    <dbReference type="PhylomeDB" id="F9UM60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-735-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="18392" checksum="67857FB65CC576D2" modified="2011-10-19" version="1">MNSDELSKLLNDYFEAYQNTTKTMMDLVAWPLSQNKLSFEQFLILRRIATTDEVTLNDIAIQRQVTRSAISRQVKSLLMQHYVFQVPDPRDRRRLYLHLTERGQQVERIVDQAITQHFDHWVNQLGAPQIDQVLKMMGTFSQQVTDLGEPQSHPVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM63</accession>
    <name>F9UM63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate oxidase</fullName>
            <ecNumber evidence="6">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pox1</name>
        <name evidence="6" type="ordered locus">lp_0849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101179.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0849"/>
    <dbReference type="EnsemblBacteria" id="CCC78302">
        <property type="protein sequence ID" value="CCC78302"/>
        <property type="gene ID" value="lp_0849"/>
    </dbReference>
    <dbReference type="GeneID" id="57024543"/>
    <dbReference type="KEGG" id="lpl:lp_0849"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.722"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_9"/>
    <dbReference type="OMA" id="TLMGWGA"/>
    <dbReference type="PhylomeDB" id="F9UM63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-738-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014092">
        <property type="entry name" value="Pyruvate_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02720">
        <property type="entry name" value="pyruv_oxi_spxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="382"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="579" mass="63498" checksum="A8D3E53A0E0D7534" modified="2011-10-19" version="1">MAKISGSDAVLKVIQKWGVKHIYGLPGGSFDSTMNAIYNQRKTLKYIQVRHEEAGAIAASADYKLTGKIGVCFGSAGPGAVHLLNGLYDAKEDGIPMLAIVAQVPTKRMNMDFFQAMNEEPIFDDVAVWNRTAMTAESLPMMTDEAIRQAYAHNGVAVLTIPKDFGWAEIEDNFETNASVHTVNYPAPTAESVADAVKLIKAAKSPMIYFGVGAKDAAEELKAASEKFKMPLVSSVLAKGIIEDDYPAYLGSTGRVAPKPGAEIGFSTDLILWVGNNVPFSIFLFNKKAKVIQIDIDSEKFGKRHHTNVAIQADAKKALAAINAAGEARDDSAFYDAAVADKKNWDKWQASFNDSTESPVRPEPIFDVLNQEASDKAVWAIDVGNVNINFERLIRMHDDQKWATSGIYATMGFGVPAALAAKVNYPDRDVYSLSGDGAFAMLSEEILAQVKYNLHIINIVFSNETLGFIEAEQTDDSHQPLSGVDLPDTDWAKVGEGYGAVGYTVRTKAEFKQALEDAKKTDKPVVIDVKLTHAMPFTTEHMYLDDAWQDKDKIAEFVKKYDAQALKPFSYFLKQAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM76</accession>
    <name>F9UM76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888829.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78315">
        <property type="protein sequence ID" value="CCC78315"/>
        <property type="gene ID" value="lp_0865"/>
    </dbReference>
    <dbReference type="GeneID" id="58789799"/>
    <dbReference type="GeneID" id="66448818"/>
    <dbReference type="KEGG" id="lpl:lp_0865"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.735"/>
    <dbReference type="eggNOG" id="ENOG502ZN07">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207080_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-751-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="49" mass="5599" checksum="5F3F39487D1CB415" modified="2011-10-19" version="1">MQFQKTNSWFSIVLDTQRQMFVATDKLHPELFAEGVTIEDAVANLQTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM87</accession>
    <name>F9UM87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnP1</name>
        <name evidence="8" type="ordered locus">lp_0883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888840.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0883"/>
    <dbReference type="EnsemblBacteria" id="CCC78326">
        <property type="protein sequence ID" value="CCC78326"/>
        <property type="gene ID" value="lp_0883"/>
    </dbReference>
    <dbReference type="GeneID" id="57024567"/>
    <dbReference type="GeneID" id="66448830"/>
    <dbReference type="KEGG" id="lpl:lp_0883"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.747"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_9"/>
    <dbReference type="OMA" id="WQSMKLV"/>
    <dbReference type="PhylomeDB" id="F9UM87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-762-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="24255" checksum="E369F5EF07BFF835" modified="2011-10-19" version="1">MQNFIQAYSWINIRFLLEGLWVTVEVSVVSIIASFIIGSVLGVLRYVKIKYLSAVVGFVVDIIRNLPLILIIFFTYFGLPHLGFKPGIIFAAILAMTIFESAMLAEIIRSGILAVDYGQMEGARANGMSYVQALWHIVFPQAIKKTIPTIVSQFISLIKDTSLATIIVLPELLNHAQIIYGQNSAYILPMFLMIAVMYFIICYALSILSRVLDKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM90</accession>
    <name>F9UM90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system, beta-glucosides-specific EIIBC component</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pts11BC</name>
        <name evidence="15" type="ordered locus">lp_0886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="15"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888843.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0886"/>
    <dbReference type="EnsemblBacteria" id="CCC78329">
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        <property type="gene ID" value="lp_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="57024570"/>
    <dbReference type="GeneID" id="66448833"/>
    <dbReference type="KEGG" id="lpl:lp_0886"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.750"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_0_9"/>
    <dbReference type="OMA" id="MINGCIA"/>
    <dbReference type="PhylomeDB" id="F9UM90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-765-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0418">Kinase</keyword>
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    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="116"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="483" mass="51505" checksum="7BD3F7DA098CA37B" modified="2011-10-19" version="1">MKNKDKQYEKVANGVLEAVGGSANISSVTHCMTRLRFNLKDESIPNDGEVQNIPGVIGVNRAGGQYQIIIGQAVSKVYDALLTVGNLTRNAPINEDLDNRPKEKLTFKSAGNMILNKLAGCLTPLIPMLIAASMFKMFAAILGPSMFNVLGTKTSLYQLFTLVGDAGFYFFPIILGYTAAKQFNTSRIISMFLGAILIDPNLIKIVTAGKAFNIFGIAMPLVNYSSTVIPIILSVWVMSYIERFFKRYVPESISTIVIPTLTIAIMLPISLCILGPAGNFIGNYICTGILAFGKLGGLPTIIAVGVVGALWEILVMTGMHLLMLTTMMMIFAQSGHENFVTLGAVAASMSVAGMCLGAALRIKDQDQKTLAWGYLIASIIGGVTEPGLYGLAIRYKRPFIGMMIGGFCGGLYAGLTTVTAYVMVPVANFLSLTAYVGGQTSNVINGVVSGVIAFVAAAIATYAIGVEANTNKQGTKEFKLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN69</accession>
    <name>F9UN69_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine/pyrimidine phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889172.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1289"/>
    <dbReference type="EnsemblBacteria" id="CCC78658">
        <property type="protein sequence ID" value="CCC78658"/>
        <property type="gene ID" value="lp_1289"/>
    </dbReference>
    <dbReference type="GeneID" id="57024914"/>
    <dbReference type="GeneID" id="66449165"/>
    <dbReference type="KEGG" id="lpl:lp_1289"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1090"/>
    <dbReference type="eggNOG" id="COG0503">
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
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        </source>
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            <dbReference type="EMBL" id="CCC78658.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="180" mass="19598" checksum="9B3FF75B4D99CDB8" modified="2011-10-19" version="1">MQTYQLTLGSLTRQLPLIRLNATTSIASFVLLGDAELTDYAARQLSQRLTTTKFDYLVTMESKGIPLAQALSQATNHPRFIVLRKNRKDYMQHPLIEPVSAITTSTPQQLVLDGTDAALINHKRVIIIDDVISSGGSLTAANALLHQAGAQVVKQMAILAEGAASERTDIDFLAPLPLFD</sequence>
</entry>
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        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004889219.1">
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    <dbReference type="STRING" id="220668.lp_1352"/>
    <dbReference type="EnsemblBacteria" id="CCC78705">
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        <property type="gene ID" value="lp_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1352"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1137"/>
    <dbReference type="eggNOG" id="COG1733">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="120"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
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</entry>
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    <name>F9UND0_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="lp_1370"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCC78719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
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    <accession>F9UNR6</accession>
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            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="5" type="ordered locus">lp_1531</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
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    <dbReference type="RefSeq" id="YP_004889369.1">
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        <property type="gene ID" value="lp_1531"/>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.1289"/>
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    <dbReference type="PhylomeDB" id="F9UNR6"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR003607">
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    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
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    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="31"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="205" mass="22914" checksum="55B55BF46F773A9F" modified="2011-10-19" version="1">MSKTIEYTEAIVPYRHEELMAKVAAQLTDKRYQHCLRVEETARQLAADNGVDVELAGIAGLLHDYAKQRDDQTFIQLIKTHGMDPNLVSYGNGVWHGYVGAELIKDELHIYNEPILNAVRLHTVGAPYMTKLDQIIFMADFIEPARDFPGVEAAREATAKSLADGVRFQIQHTLDYLIQKGAPVYPQTLATYNAWVGGVAPQFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW6</accession>
    <name>F9UNW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889419.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1591"/>
    <dbReference type="DNASU" id="1063550"/>
    <dbReference type="EnsemblBacteria" id="CCC78905">
        <property type="protein sequence ID" value="CCC78905"/>
        <property type="gene ID" value="lp_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1591"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1340"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_0_0_9"/>
    <dbReference type="OMA" id="SYITSAH"/>
    <dbReference type="PhylomeDB" id="F9UNW6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1367-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="23974" checksum="AD7029436D01C47F" modified="2011-10-19" version="1">MSHEVDPRVDKTRRRLRQALITLLQTETVDNISVQKLTSTAAVTRGTFYLHYKDKPAFVDQALDDLVSELFETAIVTVSVGDIMTNPADPLQRVHVFSLSKALSYISQHAEAFETLLLDQRQLAVNQRINQQMTTWMTKFHRDFQDQFADLEVPVSIQIAYYVSATVGLITDWLANDMIYTPHYLTKCIKKMHHLMTVGSISFTDFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNX7</accession>
    <name>F9UNX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101471.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1602"/>
    <dbReference type="EnsemblBacteria" id="CCC78916">
        <property type="protein sequence ID" value="CCC78916"/>
        <property type="gene ID" value="lp_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1602"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1351"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_1_9"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="PhylomeDB" id="F9UNX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1378-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="296" mass="31862" checksum="D69F3E7603A46C04" modified="2011-10-19" version="1">MNKQLLTEFESKWRPQINQYLDEQLQACSDQSTLTDAMRYSVLAGGKRLRPLLTLAILDTFDITTTAANLRASVAVELMHTYSLIHDDLPAMDNDQLRRGEPTNHVKFGEDVAILAGDALQPLTFEWIADSGLPASIVANQTLALAQATGPRGMVAGQVADVLGAGQHLALPALQQLHREKTGALIHYAVQAGLIQAQVQPTVQELLLQYADAYGLAFQIYDDILDVTSTPAQLGKATHKDADEHKNTYPGLLGLAGARTALEQAVTAAQTALVKASAASQRGMGLLAAFLTYFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP33</accession>
    <name>F9UP33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640407.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889486.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1669"/>
    <dbReference type="DNASU" id="1061115"/>
    <dbReference type="EnsemblBacteria" id="CCC78972">
        <property type="protein sequence ID" value="CCC78972"/>
        <property type="gene ID" value="lp_1669"/>
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    <dbReference type="GeneID" id="57025243"/>
    <dbReference type="KEGG" id="lpl:lp_1669"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1408"/>
    <dbReference type="eggNOG" id="COG2207">
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHARAC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="36809" checksum="DE5A5A0DD61B158E" modified="2011-10-19" version="1">MKIMVSEQFQCFMASLGVDLNSLLEAAGINKVVWQEQLMLSDVEYWQLMNEFDNQLTDEMILSLGNITNINTFMPSFFAALAAKNGEQAIARMATYKSLAGPVHLEIVTKPDIVNIHILGNSLGVELPRFTIMTEQLLLISLLRVGTGKLIKPISVGSKYPYGDQIDAVMGIRPQQLADNCIQFQVTDLQRAFISANNSMWAFLQPGLDQQKLAIEHNQSLLATVQALLLKKIPSGSFSIDEIATSLNLSKRTLQRHLSTLSTTFNDEVQIARRTLVVPLMKDQSLNLIEISYLLGYSDPESFSRAFKKWFHQSPSVYRQQSLGMFKN</sequence>
</entry>
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    <accession>F9UP62</accession>
    <name>F9UP62_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640439.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79001">
        <property type="protein sequence ID" value="CCC79001"/>
        <property type="gene ID" value="lp_1699"/>
    </dbReference>
    <dbReference type="GeneID" id="57025331"/>
    <dbReference type="GeneID" id="66449566"/>
    <dbReference type="KEGG" id="lpl:lp_1699"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1435"/>
    <dbReference type="eggNOG" id="ENOG502ZP4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188348_0_0_9"/>
    <dbReference type="OMA" id="KHENATV"/>
    <dbReference type="PhylomeDB" id="F9UP62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1464-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="82" mass="9490" checksum="3FE391D22FFDA614" modified="2011-10-19" version="1">MSKVYTDVFNIKHTDCTVVDTINEFSRIFIIQDKHGSRFTCLKDDARPAKKGSGHWTSASPEDAPQDYAVPYRSRKRQRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP77</accession>
    <name>F9UP77_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101520.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889530.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1717"/>
    <dbReference type="EnsemblBacteria" id="CCC79016">
        <property type="protein sequence ID" value="CCC79016"/>
        <property type="gene ID" value="lp_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1717"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1451"/>
    <dbReference type="eggNOG" id="ENOG5030ANJ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316767_0_0_9"/>
    <dbReference type="OMA" id="FKQSRTK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1479-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="99" mass="11100" checksum="A4DE499EEA8597C0" modified="2011-10-19" version="1">MGQAITRWVWLPAPIVTRQSTFKIHVGDLQRHPVPLRAAQWYQFKQSRTKLICSVPITTTQYAAVTHLAAQRLKAGQAGMLPAPEQPVMTRGTTITFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP78</accession>
    <name>F9UP78_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1718</name>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101521.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79017">
        <property type="protein sequence ID" value="CCC79017"/>
        <property type="gene ID" value="lp_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1718"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1452"/>
    <dbReference type="eggNOG" id="ENOG5030BNW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2396008_0_0_9"/>
    <dbReference type="OMA" id="WLTGCEL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1480-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="10117" checksum="C68D028096BD5B70" modified="2011-10-19" version="1">MKTRYQLQVKYDGIRSLTRCRVLAIIIASFTGWLTGCELAQATTVPTMMQTYHPWSVRGLNLESLRLLVATTVLGLVCWGLATYLKPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP97</accession>
    <name>F9UP97_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889550.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1742"/>
    <dbReference type="EnsemblBacteria" id="CCC79036">
        <property type="protein sequence ID" value="CCC79036"/>
        <property type="gene ID" value="lp_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1742"/>
    <dbReference type="HOGENOM" id="CLU_2788718_0_0_9"/>
    <dbReference type="OMA" id="ISGHHYK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1499-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="68" mass="7793" checksum="4DA221E7695EBCCF" modified="2011-10-19" version="1">MPVRGVATTFFRDGLVVVSYQWRLPTSLAQRTEVKTGPPGFPVLVSRWDAHHWTKISGHHYKLKNGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB9</accession>
    <name>F9UPB9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muramoyl-tetrapeptide carboxypeptidase, S66 family</fullName>
            <ecNumber evidence="6">3.4.17.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.13" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101543.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889572.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1768"/>
    <dbReference type="MEROPS" id="S66.003"/>
    <dbReference type="EnsemblBacteria" id="CCC79058">
        <property type="protein sequence ID" value="CCC79058"/>
        <property type="gene ID" value="lp_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1768"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1492"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_1_9"/>
    <dbReference type="OMA" id="QRIPFLA"/>
    <dbReference type="PhylomeDB" id="F9UPB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1521-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106415">
        <property type="term" value="F:muramoyltetrapeptide carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="225"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="352" mass="39032" checksum="4AE12B08DC8066F7" modified="2011-10-19" version="1">MRKYVDWKYVKIKKCYTYFNYILILWGGNTMKIGTFSASTPITALSPNRYARARRFLATQGVTLVAGNLTGRRDSYRAGSIKERAAEINALIHDDSLDILMATIGGTNANSVLAMLDYEYLNQHPKIIVGYSDATAVLLAVQTHAPNCRVIYGPALVASLGALESEIVTTTWQNFLTVYRAAPGQAVTEQAPAQWTDEAVNWETFEHPKHMHANTWHYTATPILTGRLIGGNLNTMYGFFNSPYFPKLTGNELLFIEDAEKTAATLEKNFVMLALAGVFDQISGIILGKHALYDDQGSGRLPIDILQEVLGDHQLPIIYDYDSCHTVPMLSTPLGADVRIDAQARTVTFSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD9</accession>
    <name>F9UPD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101552.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889592.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1791"/>
    <dbReference type="EnsemblBacteria" id="CCC79078">
        <property type="protein sequence ID" value="CCC79078"/>
        <property type="gene ID" value="lp_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1791"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1512"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="RWFGNVV"/>
    <dbReference type="PhylomeDB" id="F9UPD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1541-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="299" mass="32478" checksum="B04303539377CC25" modified="2011-10-19" version="1">MADAILTVKHLNKSYGHQPVLRDVSFECTQGRIVGLVGANGAGKTTIMKAILGLLSTDGEIQIAGESMQFDHHPILATVGSLIEYPSLYPYMSGWDNLRLFADGPDAQARLAAVVSALNMTDYIHQKARHYSLGMKQKLGVALAFLNQPQLVILDEPMNGLDPQGTKELRDFILKQKQAGVTFLISSHILSELQKLADDLVIIDHGKIIEKTTMTALLTTTDHFVIVKTDHDGQAKAVLVAAGYQVVADTVVKVHLAPDHQVADVLHVLTSHGLTVRDVRHETADLESTILKLLATTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH5</accession>
    <name>F9UPH5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase 4 subunit A</fullName>
            <ecNumber evidence="7">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Topoisomerase IV subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">parC</name>
        <name evidence="9" type="ordered locus">lp_1839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotetramer composed of ParC and ParE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640556.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889628.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1839"/>
    <dbReference type="EnsemblBacteria" id="CCC79114">
        <property type="protein sequence ID" value="CCC79114"/>
        <property type="gene ID" value="lp_1839"/>
    </dbReference>
    <dbReference type="GeneID" id="57025438"/>
    <dbReference type="KEGG" id="lpl:lp_1839"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1551"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_9"/>
    <dbReference type="OMA" id="PRSNRID"/>
    <dbReference type="PhylomeDB" id="F9UPH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1577-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019897">
        <property type="term" value="C:extrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00937">
        <property type="entry name" value="ParC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005741">
        <property type="entry name" value="TopoIV_A_Gpos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF9">
        <property type="entry name" value="PTHR43493:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01061">
        <property type="entry name" value="parC_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="11"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="816" mass="91702" checksum="ED81D48260BF17E7" modified="2011-10-19" version="1">MATEQPKIQELTLEDVMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYAMNQDGNTFDKAFRKSAKSVGNVMGNFHPHGDSSIYEAMVRLSQDWKLREPLIEMHGNNGSMDGDPAAAMRYTEARLSKIAGEMLQDIDKKTVDMVLNFDDTEYEPTVLPARFPNLLVNGATGISAGYATEIPPHNLSEVIDAILFLMNHPKATLEDLMDFVKGPDFPTGGIIQGLAGIKQAYETGRGRIVVRSRTKIVPLKGNKSQIEVSEIPYEVNKAQLVKKIDEIRILKKIEGIAEVRDESDRQGLSVVIELKRDVNAEGILTYLLKNTDLQITYNFNMVAIYHQRPEHVGLKTILTAYLEHQRDVVTRRTQFNLQKAMDRQHIVQGLIKAMSILDQVIKTIRGSKDKKDAKQNLVSQFDFSEIQAEAIVTMQLYRLTNTDVTQLEKESAELAKAIATYQLILAEPKELDKVLRRELKAVQKAYPTSRLTEIQNEIQELKVKTEVVIPQEDVIVMISHDGYIKRTSLRSYSASEPDDNGLKDEDYPIYLAKNSTLDHLMMFTNMGHLIYRPIYEIADAKWKDTGEHISQTIGLAENERITWVYSFENLKATGKFLVATSDGYIKQTAFADYTPGRTYKTRASQFIKMKSDDATVVTVEYLPAAPTGTLILITQHGYGLRYDLSEVPTIGAKAVGVKSMDLRDDAIVRATIAADDDLIAMITQRGSFKKMKVADLPVTSRARRGVQVLRELKNNPHRVADYVLVASDANGVALDVLTDRGKHHSILNDDHPTSARYSNGSFVVDTDTEGEPVSMQIHPIPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR6</accession>
    <name>F9UPR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889719.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1946"/>
    <dbReference type="EnsemblBacteria" id="CCC79205">
        <property type="protein sequence ID" value="CCC79205"/>
        <property type="gene ID" value="lp_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1946"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1643"/>
    <dbReference type="HOGENOM" id="CLU_2260208_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1668-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11553" checksum="4143FCDB22E1F1D7" modified="2011-10-19" version="1">MENGGLKTYIRRRVTTKRSEITVNQRPPSVRNGRSIDIVLAGSYTSEKWIGCVGMKFVIFGGELLVLAAWLIYGRTLPLSLRIIGVIGIVIVSQWAHWVLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPY7</accession>
    <name>F9UPY7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4 9">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aldB</name>
        <name evidence="10" type="ordered locus">lp_2030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2030"/>
    <dbReference type="EnsemblBacteria" id="CCC79276">
        <property type="protein sequence ID" value="CCC79276"/>
        <property type="gene ID" value="lp_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2030"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1715"/>
    <dbReference type="eggNOG" id="COG3527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_0_0_9"/>
    <dbReference type="OMA" id="MANCIYQ"/>
    <dbReference type="PhylomeDB" id="F9UPY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1737-MON"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="PTHR35524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="236" mass="25932" checksum="1F5019BBABEA4607" modified="2011-10-19" version="1">MDTTTIFQHGTLGLLVPGLFDGTITAGELLTHGDTGIGTLDGLNGEVIILGGHAYQAREDGQIREIQPEETLPFASVHFEKPDISAQLAAITQTDFEQQVVHDYRLTNVFAAIRVDGTFAKVKTRVAPRQEPPYKTLVAATATQPEFTGEHVDGTIIGYYAPHLFQGATVGGFHLHFLSKDHQLGGHLLGFEVEQATLKVQHFADFHVHLPIDNEAYLQEQFDNEAIDHAINKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ44</accession>
    <name>F9UQ44_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PTS system, fructose-specific EIIABC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">fruA</name>
        <name evidence="17" type="ordered locus">lp_2097</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889847.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2097"/>
    <dbReference type="EnsemblBacteria" id="CCC79333">
        <property type="protein sequence ID" value="CCC79333"/>
        <property type="gene ID" value="lp_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2097"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1774"/>
    <dbReference type="eggNOG" id="COG1299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013155_1_0_9"/>
    <dbReference type="OMA" id="CKLMAPH"/>
    <dbReference type="PhylomeDB" id="F9UQ44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1794-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="14">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="15">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="16">
        <location>
            <begin position="308"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCC79333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="655" mass="68564" checksum="A8BA473458AF7ED7" modified="2011-10-19" version="1">MDIRDLLLKDVMIMDMHATTKDEAIDELVHKYAEQGIINDEALYKQDIIKREAESTTGIGDGIAMPHAKDKAVNRATVMFAKSKAGVDFNALDGQPVHLFFMIAAPEGANNTHLAALAALSSLLIDPELVAKLKNAQSPEEVQQLFGDAQAAKEEKEAKDAAAKAEKEAAAASTTTDEKRPYLVGVTACPNGIAHTYMAEAALIKAGEAAGVDIKIETNGSEGVKHLLTADEIARADGVVIAADKKVKMARFDGKHLVNRPVTDGINNADQLVQEALSGKAPVYHDADGGAADDDEGGSANGSVWGEVYKDLMNGISHMLPFVVGGGILMALSFIIEQFVGSKSLAFTFFNQAGNMAFAFMVPVLAGYIAESIGDRPALMPGFVGGFMATVYTGAYGGVYTASITANAKSPAGFLGGLAAGFLAGYITVWMKKWTKNMPQSLDGMKPMLIFPILGLLIIAALMFFVVNPIFSVINAWITHFLNSMGTGNAVLLGLVLGGMMSIDMGGPFNKAAYVFATGAFTATGHGNLMAAVMAGGMVPPLATAIATAFWPKKFTDDERKAGISNWLLGISFITEGAIPFATADPLHVIGSSVIGAAIAGGLTQLWGVAVPAPHGGLWVSLLATNIWGYIGATIIGAVIAGVILGLWKPAKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD4</accession>
    <name>F9UQD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ and Co2+ transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889937.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79423">
        <property type="protein sequence ID" value="CCC79423"/>
        <property type="gene ID" value="lp_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2206"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1864"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_9"/>
    <dbReference type="OMA" id="IMDIQKS"/>
    <dbReference type="PhylomeDB" id="F9UQD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1884-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="36068" checksum="A0FBD9713FD25D57" modified="2011-10-19" version="1">MLQYFTTGKNGLLTTPDDHHDQPYWINVERPTSTEIDQLVTQFDLPKDYLTAILDDAEVSRAEQLSTTQSSQPILIVMQYPKLTTSKLGYLEFQVYPFALILVDQVVITVSNYPASFIQDFVMDPASSKLSLDNHEDFVLTIMWYIEHSFVTALELINQRTSALESRLNQATHNVELFTIMAYQKSLIRFKAALNQNTPTLDAVETSITHFNAPNHQSLTDDIKIETQQASDMAETTNQILQQYSQLVGSVISNNLNDVMKFLTSLTMVLTIPTIIGGIYGMNVKLPGAGLVHAFTWLMLGTIILCIISIEYLRNHDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF3</accession>
    <name>F9UQF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644623.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2229"/>
    <dbReference type="EnsemblBacteria" id="CCC79442">
        <property type="protein sequence ID" value="CCC79442"/>
        <property type="gene ID" value="lp_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2229"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1884"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_1_9"/>
    <dbReference type="OMA" id="HIPPWTD"/>
    <dbReference type="PhylomeDB" id="F9UQF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1903-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="26838" checksum="86959F063D3E02E9" modified="2011-10-19" version="1">MKLTVLGYYGGYPYDGVGTSSYLITAGDYHLLLDCGSGALNALEEILDPLQLDSVLLTHYHHDHTADVGVLQYYWQLRAGERKTPVLPIYGHTADPLNFGALTWANATEGRAYDPAAVNQIGPFDVSFLPTKHPVPAYAVKLVERATGQELVFSADTAYLPELATFAAGAQLLMTDTNFAADKTGKMWHMTSAQSGKIAKDARVKKLLLTHLPQDVSFTQLQQEAQAAAGNDIQVTVAQKFLQLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF5</accession>
    <name>F9UQF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2231a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101691.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889958.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2231a"/>
    <dbReference type="EnsemblBacteria" id="CCC79444">
        <property type="protein sequence ID" value="CCC79444"/>
        <property type="gene ID" value="lp_2231a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2231a"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1886"/>
    <dbReference type="eggNOG" id="ENOG5030A5C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1978715_0_0_9"/>
    <dbReference type="OMA" id="YTIGIDV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1929-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14366" checksum="91548B67F7758220" modified="2011-10-19" version="1">MQKKVAGTIIYNDQQGSHFLVKHSTNGYNFYQLLVRAGHSPLASVLWDLRYTIGIDVDQLRLYDSIMAELDDEKVAVFVFDHLAVDGQVRAKFDRQGLEFVLASELHELFTSVRVSETMPFTNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH5</accession>
    <name>F9UQH5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641543.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889978.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2255"/>
    <dbReference type="DNASU" id="1061456"/>
    <dbReference type="EnsemblBacteria" id="CCC79464">
        <property type="protein sequence ID" value="CCC79464"/>
        <property type="gene ID" value="lp_2255"/>
    </dbReference>
    <dbReference type="GeneID" id="57025801"/>
    <dbReference type="KEGG" id="lpl:lp_2255"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1907"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087946_0_0_9"/>
    <dbReference type="OMA" id="ELAMNPT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1949-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="32685" checksum="80F2BB67A166F38E" modified="2011-10-19" version="1">MTQLIMRPRPGKIKLGLKASQAPAQLMDRLQYRPEVFEFFTSATDFEPEAFQTLKTAVQFVKTTVTEQIVIHHPMSYQGVHLDQLLDPHREAAAYQFLQTSTAQLLALATELDVKVLVHGGYGSDSGRLIDEYESLQVARDVVFERLDNLVRQASGHVVIENGVTASFMYGDPQLDERIIQHHYPLVCDLSHVFIALHGDMELTMLALKRLAPLIQHYHLVDSMGTRHDSLPLGQGLIDWQRVLPVLNPHATMIYEVPDETDATCANMLSSYHYLRALELRSIEGGQAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI5</accession>
    <name>F9UQI5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645445.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2266"/>
    <dbReference type="EnsemblBacteria" id="CCC79474">
        <property type="protein sequence ID" value="CCC79474"/>
        <property type="gene ID" value="lp_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2266"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1917"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_2_0_9"/>
    <dbReference type="OMA" id="ICFGHSH"/>
    <dbReference type="PhylomeDB" id="F9UQI5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1959-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="19029" checksum="2D81D374D0BBD528" modified="2011-10-19" version="1">MKCLVVSDSHGDRDVLVRLLDKYRGQVDAFFHCGDSELPHDDAVFQEMFTVQGNMDFDAVIPNEVNPTIDEVTVYMTHGHLVGVNMGLDHLLANAEVHNAKLAFFGHTHQLGVERRGGVVVLNPGSITYPRGEFARIGGTYAIVTTSAAGIDVQYYDRQLQAVPELKFHFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ5</accession>
    <name>F9UQQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine cleavage system, H protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcsH2</name>
        <name evidence="4" type="ordered locus">lp_2353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101722.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2353"/>
    <dbReference type="EnsemblBacteria" id="CCC79544">
        <property type="protein sequence ID" value="CCC79544"/>
        <property type="gene ID" value="lp_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2353"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1989"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_3_1_9"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="PhylomeDB" id="F9UQQ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2028-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="10487" checksum="334C82902B5BABC0" modified="2011-10-19" version="1">MSEDAAYFWTKDVDGHTRLGLTKAAHETLGEVKYAELPAIGDKVSQNSAFLSVEATKAVSEFNCPINGTVVAVNPALSENFDALNSVEDGVAWLIDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX7</accession>
    <name>F9UQX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P2a protein 20, replication protein DnaD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2437"/>
    <dbReference type="EnsemblBacteria" id="CCC79616">
        <property type="protein sequence ID" value="CCC79616"/>
        <property type="gene ID" value="lp_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2437"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2060"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074315_2_0_9"/>
    <dbReference type="OMA" id="PVEHKEL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2102-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="36366" checksum="C05E5358001E7640" modified="2011-10-19" version="1">MNAAVTESTEWVKGPLIRTGGANLDYFKQRRAYRNFKMYEASVSNGQNNLYRELLDYANDEGKLDVQFRMKNSALLSLTGLSEPGLDKARNSLVQLGLIKYARGKKNVKPPEYRIINLYSRSAGYPTSNPTTSHKSRPTGLDEVGQLVGQGGGQPVEHKELTNTDPDLTDTDSYDDDAGVTREQVINDWTNLWGFPNGVARPEIDEWLAVLKPELVAYAIQIAGEHDVQSRGALKYVRAIIAGWKKRNITTLEQAKKAAANHDDRMKSERKPSGYSKPRRKEVTPKWMQKGASQADSKSNSSDDQQDDMSDEAFLAFMNSQEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA0</accession>
    <name>F9URA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine nucleosidase</fullName>
            <ecNumber evidence="4">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2591"/>
    <dbReference type="EnsemblBacteria" id="CCC79739">
        <property type="protein sequence ID" value="CCC79739"/>
        <property type="gene ID" value="lp_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2591"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2175"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_3_0_9"/>
    <dbReference type="OMA" id="HFNGGNI"/>
    <dbReference type="PhylomeDB" id="F9URA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2230-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="IUNH"/>
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        <location>
            <begin position="6"/>
            <end position="304"/>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
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</entry>
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    <name>F9URD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="CCC79776.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>F9URF6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="19802" checksum="13A14EA0AE1FFA3E" modified="2011-10-19" version="1">MAANETYADWQARMAKVILPKWIELPNFDLYMDQVLLLINETLQPLGADPVTAAMINNYVKHKVILSPVKKKYQIMQLADIIVISLLKPSYPLDKIRQGIDQVTATGYPKRAYDNFITVLTNQLHHPDDPITISDQDLSHSLTTAAAQLIVNKLRTDELLRLNQVQTKPQQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM2</accession>
    <name>F9URM2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890375.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79861">
        <property type="protein sequence ID" value="CCC79861"/>
        <property type="gene ID" value="lp_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2748"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2301"/>
    <dbReference type="eggNOG" id="ENOG50309V4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675662_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2352-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17912" checksum="EF96311F9F862D10" modified="2011-10-19" version="1">MIGHITVMQPDYDQGILTDFHGRHFKFRLTAVWPSSALHIGAEFYFRPQLTAAGLVAVELRYQHHDGTCLSVRPPTEVSQQVMIRIGELALNTDDIQYYALTTDQAEVRNGYASSARHLVIKMRCGRQYIFYNWDGVNIDDVVTKLATLHTVQRQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN4</accession>
    <name>F9URN4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, histidine triad family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642555.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890387.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2763"/>
    <dbReference type="EnsemblBacteria" id="CCC79873">
        <property type="protein sequence ID" value="CCC79873"/>
        <property type="gene ID" value="lp_2763"/>
    </dbReference>
    <dbReference type="GeneID" id="57026134"/>
    <dbReference type="KEGG" id="lpl:lp_2763"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2313"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_5_1_9"/>
    <dbReference type="OMA" id="YNIGVNC"/>
    <dbReference type="PhylomeDB" id="F9URN4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2364-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13357" checksum="6E7B7E439685868E" modified="2011-10-19" version="1">MACIFCQPLPYILENDLAAAFFDKKPVSPGHLLIIPKAHYATYFDVPTATRNAMLALLTQAKAYLDAHNHPDGYNIGINVDPAAGQTVMHCHLHLIPRYQGDVPDPAGGIRKMLPDGVPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT1</accession>
    <name>F9URT1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2823"/>
    <dbReference type="EnsemblBacteria" id="CCC79920">
        <property type="protein sequence ID" value="CCC79920"/>
        <property type="gene ID" value="lp_2823"/>
    </dbReference>
    <dbReference type="GeneID" id="57026185"/>
    <dbReference type="GeneID" id="66450460"/>
    <dbReference type="KEGG" id="lpl:lp_2823"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2361"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="LPWLTCF"/>
    <dbReference type="PhylomeDB" id="F9URT1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2417-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="24834" checksum="099298DB2B6D96D9" modified="2011-10-19" version="1">MSQPVLALQNINKQFGHGHTAVNALTDANFEVSAGQFVAIIGPSGSGKSTFLTIAAGLQTPTSGQVILNGQPLSNQTEKQRLAYRFNEIGFILQSSNLIPFLTVREQFKLVDKMARRKFDQAGTDELLAELALTEVRDAYPSDLSGGERQRVAIARALYNDPSVILADEPTASLDTPRSIDVVKRLANEAHQHQKAIVMVTHDQRLIDDCDVVYQIEDGKMSRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
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        <name evidence="2" type="ordered locus">lp_2872</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2872"/>
    <dbReference type="EnsemblBacteria" id="CCC79961">
        <property type="protein sequence ID" value="CCC79961"/>
        <property type="gene ID" value="lp_2872"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2872"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2404"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="DNDYYAH"/>
    <dbReference type="PhylomeDB" id="F9URX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2458-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="198" mass="21289" checksum="CDEE6C23631005BE" modified="2011-10-19" version="1">MKRVLIVGATGTIGGVVRQTLLNETDNQLTLFARSANRLKTSERESVIAGDVTKDSDLDKAIAGQDVVFVALSGSLGRFAQKIVAAMDRNKVSRLLFITSMGIYDEIPASVGASGNLSSNPMLRTYREAADVVEASDLNYTLIRPGWFTGGPVDYEITKKGEPFGGHDVSINSIADFVKNAIVDNDYYAHDSVGLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9US10</accession>
    <name>F9US10_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-01" db="PDB data bank">
            <title>Crystal structure of putative carboxylesterase (NP_786266.1) from Lactobacillus plantarum at 1.70 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2008-05" db="PDB data bank">
            <title>Crystal structure of lipase/esterase (lp_2923) from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR108.</title>
            <authorList>
                <person name="Forouhar F."/>
                <person name="Su M."/>
                <person name="Seetharaman J."/>
                <person name="Mao L."/>
                <person name="Janjua H."/>
                <person name="Xiao R."/>
                <person name="Ciccosanti C."/>
                <person name="Maglaqui M."/>
                <person name="Foote E.L."/>
                <person name="Zhao L."/>
                <person name="Everett J.K."/>
                <person name="Acton T.B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH CALCIUM</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="5">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="6">
        <citation type="journal article" date="2013" name="FEBS J." volume="280" first="6658" last="6671">
            <title>Structure, biochemical characterization and analysis of the pleomorphism of carboxylesterase Cest-2923 from Lactobacillusplantarum WCFS1.</title>
            <authorList>
                <person name="Benavente R."/>
                <person name="Esteban-Torres M."/>
                <person name="Acebron I."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
                <person name="Alvarez Y."/>
                <person name="Mancheno J.M."/>
            </authorList>
            <dbReference type="PubMed" id="24127688"/>
            <dbReference type="DOI" id="10.1111/FEBS.12569"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS)</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-8794390">
            <id>F9US10</id>
        </interactant>
        <interactant intactId="EBI-8794390">
            <id>F9US10</id>
            <label>lp_2923</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890513.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="PDB" id="3BXP">
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        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=1-276"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-276"/>
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        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=1-276"/>
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        <property type="method" value="X-ray"/>
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    <dbReference type="SMR" id="F9US10"/>
    <dbReference type="MINT" id="F9US10"/>
    <dbReference type="STRING" id="220668.lp_2923"/>
    <dbReference type="DNASU" id="1063342"/>
    <dbReference type="EnsemblBacteria" id="CCC79999">
        <property type="protein sequence ID" value="CCC79999"/>
        <property type="gene ID" value="lp_2923"/>
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    <dbReference type="KEGG" id="lpl:lp_2923"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2441"/>
    <dbReference type="eggNOG" id="COG0657">
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    <dbReference type="PhylomeDB" id="F9US10"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="IntAct"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
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        <property type="entry name" value="AB_hydrolase_3"/>
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        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3D3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4BZW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="4BZZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="4C01"/>
        </source>
    </evidence>
    <sequence length="276" mass="30419" checksum="FA8717CA1728CB18" modified="2011-10-19" version="1">MQVEQRTLNTAAHPFQITAYWLDQISDFETAVDYPIMIICPGGGFTYHSGREEAPIATRMMAAGMHTVVLNYQLIVGDQSVYPWALQQLGATIDWITTQASAHHVDCQRIILAGFSAGGHVVATYNGVATQPELRTRYHLDHYQGQHAAIILGYPVIDLTAGFPTTSAARNQITTDARLWAAQRLVTPASKPAFVWQTATDESVPPINSLKYVQAMLQHQVATAYHLFGSGIHGLALANHVTQKPGKDKYLNDQAAIWPQLALRWLQEQGLLAGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9US54</accession>
    <name>F9US54_LACPL</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="2" type="primary">malZ</name>
        <name evidence="2" type="ordered locus">lp_0025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888115.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0025"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77601">
        <property type="protein sequence ID" value="CCC77601"/>
        <property type="gene ID" value="lp_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0025"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.23"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_4_9"/>
    <dbReference type="OMA" id="IVGEEWS"/>
    <dbReference type="PhylomeDB" id="F9US54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-22-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="138"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="605" mass="69505" checksum="442AEE2A18C56D8D" modified="2011-10-19" version="1">MQVTYNSFLPTYKTPFGAVTRQTPVQFTISVQTVTPVKQIDLCVAHDGQWDDEQALPLHPISPTMYTATFIPTQVGLYFYYFRIETATMTAYYGCVDGGYGGPGVQYVLREHVQMYQLTILKAVETLPQWYREGVAYQIFVDRFNNGNADGHVNAPKPNSFIYGQLTDRPLYVRDEHRAILRWDFYGGNLRGISAKIPYLQRLGVTIIYLTPIFEASSNHRYDTGDYLKIDPVVGDLTDFDNLVAAVHRAGMRLILDGVFNHVGVDSKYFNQAGHYPTVGATQSTTSPYYPWFTFIHYPHDYDSWWGIRDLPTVDKDDPTYRDFIFGKPDSVIDYWTQRGVDGWRLDVADELPDDFIAGIRRTLDRYPDKVLIGEVWEDASHKLAYGMRRHYLEGGGLQAVMNYPLRRLIIHVLNGTLTPAEWWRELMTLKENYPATTFRFNFNNIGSHDTPRILTMLAEDRQRLRLAVQLLLTLPGVPCLYYGDEALMMGGKDPDNRAFYPWQDADQAQVQFVADWANWRQRHPWLNTAHFVPFYLADYGIGYLYWQADQTVMVIVNVTTEPRTMTSHDLKLSGVPIKLAQAIQCCLVTQTLGGEQLRLIENFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB9</accession>
    <name>F9USB9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular zinc metalloproteinase, M10 family</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">zmp3</name>
        <name evidence="7" type="ordered locus">lp_2988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890563.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2988"/>
    <dbReference type="EnsemblBacteria" id="CCC80049">
        <property type="protein sequence ID" value="CCC80049"/>
        <property type="gene ID" value="lp_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2988"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2494"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089949_0_0_9"/>
    <dbReference type="OMA" id="FLVYSTE"/>
    <dbReference type="PhylomeDB" id="F9USB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2544-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ZnMc" evidence="6">
        <location>
            <begin position="112"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="266" mass="28106" checksum="83C0DCB990AC2861" modified="2011-10-19" version="1">MLKNLMRGIKALCLIGLVLFGWRNYDTLAPRAAALYQTSRQNLAAALSGDLSSHLLGADDTSSATEDSATNSSKQSSGQQTDKTASASSVTSSSSQATSSTTQATPIESIVQNATLKKTYYYSFDHNVPKAARQVFLEAVATYNQTGLVHLVAGQASGSQNSVTFSMYHKKMTTGATSVELGHGGPDITKQISWRGTQYWNNATASLNGSYASAFSKSVAVHELGHALGLDHSSSTESVMYPVSQGKSTLSSADIAALQTIYQKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD7</accession>
    <name>F9USD7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts23C</name>
        <name evidence="11" type="ordered locus">lp_3010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890581.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3010"/>
    <dbReference type="EnsemblBacteria" id="CCC80067">
        <property type="protein sequence ID" value="CCC80067"/>
        <property type="gene ID" value="lp_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3010"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0808">Transferase</keyword>
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            <begin position="13"/>
            <end position="460"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="490" mass="52205" checksum="02370EFA3990B384" modified="2011-10-19" version="1">MENSSNGAVSNFINNKVLPPIMKFVNTKPVKALQDGMVYALPFIIIGSVFLILSNIPIPAVAAVIKASGWAAFFNQAYTVTFGVLSLWAAVGIAYVYVRNEGYEPLPAGLTSMAVFLLLQTLNIANPLVAAMGKAGTGITNAAGNVVMSGSAVSQNIDKLPKVLQNFVQAPVTGVVNITWLGGQGMIAAIIVGILVGWAYSAMIRKGWKITLPEQVPASVANQFTAMIPAGVILIVAMLIFAAFSAFGNTDMLQFIYKVLQTPLQGLSDSLGGALVIAFLVPFFWFFGVHGGLIMGAITSGLLIPNTFDNASLYKAGKLTVAQGAHIVTNEFYNNFINLTGSGITIGLVIFTLFAAKSVQFKTIGKVEFIPALFNINEPFLFGLPIVMNPFLAIPFFLTPVIVALSTYLVIYFGIVPPLNGFAAPWTTPAIISGFLIGGWKMAIWQTITLVMSTAIYFPFAKKYDAILTKEEGEKAAAEAAAGNAEIEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="lp_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3065"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2560"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <feature type="signal peptide" evidence="2">
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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            <begin position="25"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="15678" checksum="A7C8CD0BB4B46BE8" modified="2011-10-19" version="1">MPNKWWRLILGVMLVLSWAIPVRAATHGRTEISVGFYETKYSADRIIPARVIPDGGHPYVIRPADPGTQGQRNQSERKPIRRQLIIDGWLRGQSRNGQQLPQTSERLVIGSILGGMGLLASVLAGALYRILKRQDGGERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL3</accession>
    <name>F9USL3_LACPL</name>
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        <submittedName>
            <fullName evidence="13">Hypothetical membrane protein, DUF1211 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">lp_3099</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80143">
        <property type="protein sequence ID" value="CCC80143"/>
        <property type="gene ID" value="lp_3099"/>
    </dbReference>
    <dbReference type="GeneID" id="57026409"/>
    <dbReference type="KEGG" id="lpl:lp_3099"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2589"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090238_1_2_9"/>
    <dbReference type="OMA" id="WREKNED"/>
    <dbReference type="PhylomeDB" id="F9USL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2636-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="21753" checksum="C35EFB46619D5BB5" modified="2011-10-19" version="1">MNKARLEAFTDAIIAIVLTLLVLDLPRPQTPSVRALFAEWQSIYVYIITFTLLISIWLNHHDLFVQVKKIDRVVFWANSFWLLCQSFIPFMASWITKFPHSKWPAVFYILTGFVWMLAYQLLVAAVRRLNPHIHRMSSPALSVVFGGFLVVLTVALINPDVGLFLIPVHAFASVILATKRKWHLRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS4</accession>
    <name>F9USS4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888169.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0099"/>
    <dbReference type="EnsemblBacteria" id="CCC77655">
        <property type="protein sequence ID" value="CCC77655"/>
        <property type="gene ID" value="lp_0099"/>
    </dbReference>
    <dbReference type="GeneID" id="57026941"/>
    <dbReference type="GeneID" id="66448239"/>
    <dbReference type="KEGG" id="lpl:lp_0099"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.79"/>
    <dbReference type="eggNOG" id="ENOG5030A8B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2633598_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-77-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="77" mass="8857" checksum="E8FD143A19874490" modified="2011-10-19" version="1">MLNPNTEIHRGWNRRVVTGKTLAECDERLVKYLNDQDYGSGEFVVLHENDGSNENTGYDLPDGDNCYISFLIYNSRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS8</accession>
    <name>LARR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactate racemization regulatory protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Transcriptional activator LarR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">larR</name>
        <name evidence="6" type="ordered locus">lp_0103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="J. Bacteriol." volume="197" first="219" last="230">
            <title>Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Bakouche N."/>
                <person name="Diman A."/>
                <person name="Viaene E."/>
                <person name="Dandoy D."/>
                <person name="Fontaine L."/>
                <person name="Hallet B."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="25349156"/>
            <dbReference type="DOI" id="10.1128/JB.02192-14"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>DNA-BINDING</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Positive transcriptional regulator that is absolutely required for the expression of lactate racemase (Lar) activity. Controls Lar expression by sensing the L-/D-lactate ration. Binds to a 16-bp palindromic sequence (Lar box motif) that is present in the larR-larA intergenic region, allowing transcription of the larABCDE operon.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">L-lactate acts as a positive effector on the binding and multimerization of LarR on DNA, while D-lactate antagonizes the positive effect of L-lactate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Multimerizes on DNA. Multimerization is required for transcription activation.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced by L-lactate but not by a racemic mixture of DL-lactate. Makes part of the larR(MN)QO operon.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9USS8"/>
    <dbReference type="SMR" id="F9USS8"/>
    <dbReference type="STRING" id="220668.lp_0103"/>
    <dbReference type="DNASU" id="1061368"/>
    <dbReference type="EnsemblBacteria" id="CCC77659">
        <property type="protein sequence ID" value="CCC77659"/>
        <property type="gene ID" value="lp_0103"/>
    </dbReference>
    <dbReference type="GeneID" id="57026945"/>
    <dbReference type="GeneID" id="66448243"/>
    <dbReference type="KEGG" id="lpl:lp_0103"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.83"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_12_0_9"/>
    <dbReference type="OMA" id="MTMNGKK"/>
    <dbReference type="PhylomeDB" id="F9USS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-81-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000441648" description="Lactate racemization regulatory protein">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25349156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="25349156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="25692" checksum="BB04358320261234" modified="2011-10-19" version="1">MVLTDIEYLLSYLEAHHVPTIKKKRHTYLTYHGLAEHYTYVLKDGIIKNSIILQDGREYNLSYIAKPDVISLLRDEVSRSTDQPFNVRIESEYATFYQVNRVAFWKYVNSTPELQNYVKNYYRKKLSENILRLQRMVMNGKKGAICAFIYSLVDLFGRKVNEGILIDFVVTNDDIAGFCGISSRSSVNRMLKELRTDGVITVKNHKFIIQDVSYLLDQIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST5</accession>
    <name>F9UST5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        </source>
    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC77666.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="34082" checksum="3C3B6A62E90251C6" modified="2011-10-19" version="1">MQALVVPDPSAQTMEQLQWQERPMPNLGPTEVLIKTQAVGLNPVDFKLVAAGNAAWQYPHTLGLDTAGIVEAVGAEVTNFRPGERVCGHANLANNGTFAEYVSLPAAVLAKIPTTVSFEAAAASLCAGLTAYQALLRKANLNAAQTVLIHAGAGGVGSMAIQLAKAAGKTVFTTVSKAKQAFVAPLHPDAQIDYHHEDVTTRIQDLTQQHGVDLIINTIGHADADLPRLAYNGQLVCVLATPDHFPSNQVVTISKLDLGGAHRSGNPAQVADLGQMTAALLALVQAGKVDPLITQVLHRDQLVTGLQQLQAGQVVGKLVVTFDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST9</accession>
    <name>F9UST9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxymethylpyrimidine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiP</name>
        <name evidence="7" type="ordered locus">lp_0116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0116"/>
    <dbReference type="EnsemblBacteria" id="CCC77670">
        <property type="protein sequence ID" value="CCC77670"/>
        <property type="gene ID" value="lp_0116"/>
    </dbReference>
    <dbReference type="GeneID" id="57026956"/>
    <dbReference type="KEGG" id="lpl:lp_0116"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.94"/>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048240_1_0_9"/>
    <dbReference type="OMA" id="AFEIIVM"/>
    <dbReference type="PhylomeDB" id="F9UST9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-92-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytosine transmembrane transporter activity"/>
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        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012732">
        <property type="entry name" value="Thia_CytX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02358">
        <property type="entry name" value="thia_cytX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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        <location>
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            <end position="136"/>
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    </feature>
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            <end position="168"/>
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    </feature>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="399" mass="42574" checksum="A81D05C36BE93B79" modified="2011-10-19" version="1">MKHDGIFRSQFLLWLGAAISIAEILTGTLMAPLGLTRGLAAIVLGHLIGCGLFLVPAGYLGAKLHQSALASAQLAFGRGGVLLASGLNALQLVGWTAVMIVNAQLAMNSISGKLFGFRSPLLMATIVAILIIAWLLMGSQLLFKINNAVVGLLVLGTVLMLVMVFMAPTTSQSVSPTSMTFGQAVELNVTMALSWLPLIGDYTQRVDRPLPVALVSAGGYMLGSLVMFVTGLLVVLRTGQTDITALLTRSGLGLVALLIIVFSTVTTTFLDTYSAATSLANLTGSRHVNRLAVGVTVVGLLIALTVAMTYYQNFLYLIGSVFTPLYAIIFVTYFVRHATLPYWLNFCWWVVGIVAYYQLQAIDFIGGTTLLVLVGLSIAVWLTGIIVKPTALGYRELSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Glutamine amidotransferase, class I</fullName>
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    <gene>
        <name evidence="1" type="ordered locus">lp_0117</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77671.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0117"/>
    <dbReference type="EnsemblBacteria" id="CCC77671">
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        <property type="gene ID" value="lp_0117"/>
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    <dbReference type="HOGENOM" id="CLU_030756_2_1_9"/>
    <dbReference type="OMA" id="PEYWAET"/>
    <dbReference type="PhylomeDB" id="F9USU0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="26242" checksum="172AEE5C3FB125A3" modified="2011-10-19" version="1">MVKPIIGIAPGVVTVNSQMFPGRVRDYVNRDYLKSVTDNGGVPLVLPVTTDATTIERYVGMIDGLLLCGGADVAPLTYGEEPQPKLGGVDPERDQYEIALIRATHAVGKPVLGICRGLQILNVCYGGNLYQDMSELPAGQGTLKHMQGQLAAYGMHHVKVVPGTTLAEYLGTTSDAIAINSFHHQAVKQVATGFQVVAQSADQVVEAIEATAGGLQLGVQWHPEMMQQVNSMQARLFAAFVRACVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV9</accession>
    <name>F9USV9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside 2-deoxyribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0138"/>
    <dbReference type="EnsemblBacteria" id="CCC77690">
        <property type="protein sequence ID" value="CCC77690"/>
        <property type="gene ID" value="lp_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0138"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.114"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117644_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-112-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="16798" checksum="BC410D4AE8977B12" modified="2011-10-19" version="1">MSTRLMSDEPTIYLAGPWFTEGQPERLAKIEKLMDELELTYYSPRLDGIDLTPDATEADRNAVFTDNVDHLKRAKLVVAVVDGFDTGTIWETGTAYGLDIPVAYYSETLADGTFNVMLAKSGKAVIENMTDLKAFLQDPTADDFQYTGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX4</accession>
    <name>F9USX4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100908.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888219.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0161"/>
    <dbReference type="EnsemblBacteria" id="CCC77705">
        <property type="protein sequence ID" value="CCC77705"/>
        <property type="gene ID" value="lp_0161"/>
    </dbReference>
    <dbReference type="GeneID" id="57026992"/>
    <dbReference type="KEGG" id="lpl:lp_0161"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.130"/>
    <dbReference type="eggNOG" id="COG3559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036785_2_0_9"/>
    <dbReference type="OMA" id="GDRWWVL"/>
    <dbReference type="PhylomeDB" id="F9USX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-127-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="538" mass="58752" checksum="9BDEB372BC1DAE62" modified="2011-10-19" version="1">MATQLFARTGLLIRFNLRRDWKKLLIWVVVLTGLFTAIAAKFDGIYGTQMALNEIVKTLKTPAMISLFGAFSAKSPYTTAKVFATEMVVFMAIVMIVMNIMVAVVTTRGDEDDGLLELVRAHAVGRLAPLFAGAAELTALNGLIGFLFALGLTVAKLPGATTPGNWLIGLGLGGLGWAFGMLTLLLAQVMTSASGTTMLSYLLLGVMYVARMGTDVNRPDLTWWIPFGWIEKLDAYQTNDWLPIGLYVLLGLGCSSLAAALNAYRDLGAGLVEPRRGRRQASGLLRGPVTLLWRQAHGLIIAWLLGNFILGAAYASVFNTIGDLAKSNPMIKQLLGASALAAANRLIVKNFIAVLAIVMVIVALVPAVQLMLKLVNDEQKGYLHQVYATATSRWHVWASYTGWAIVTGLLVLLAGLSGMYLMGLTSMVKPISWVTYWHVFAAYAPAMLVMVAVTSALAGWRPKWRYAAWIWVFYAFFSLYLGNLIDLPKWARRLTPLGFVNKVPIKPLDGTTSSWCLLLTVLILVVAALSYRRRDLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY8</accession>
    <name>F9USY8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltodextrin ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdxF</name>
        <name evidence="7" type="ordered locus">lp_0176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641771.1">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.144"/>
    <dbReference type="eggNOG" id="COG1175">
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    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="PhylomeDB" id="F9USY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-141-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="183"/>
        </location>
    </feature>
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            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
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            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="190"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="429" mass="47330" checksum="2F9EEE1B92EF0A45" modified="2011-10-19" version="1">MQVKDVKKAQRLSIIPGLGQLYNGQTIKGVGFIIILLAFIAEFIFGGFSAFANLVTLGSVSMEDNSLFMMIYGTLQILLTIVFIVFYIANLYDAKHVAQLINNGKKVSHTFKELGASLVDGGFAYLLTTPAYILMVFTIVFPVLVTLLMAFTNYDFAHIPPAMLLDWIGFKNFTSMFFLSSYRATFNAVFGWTVIWTVCATTLQIIIGIATAVIANQNFIKGKRFFGVIFLLPWAIPAFVSIMSFSNIFNDSAGAINVQVIGLWNTLVPFAHIAPIHWMTDTFWTKVAIIMIQGWLGFPYIYVMITGILQAIPEDLYEAATLDGATVMQKFNKITLPTIFAIAAPIFVTQYTFNFNNFSMIYLFNQGGPGDVGANAGGTDILISWIYKLTTGTSPQYSLAAAVTLIISVLVIGISLIVFKKTHAFEMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT78</accession>
    <name>F9UT78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3164"/>
    <dbReference type="DNASU" id="1064002"/>
    <dbReference type="EnsemblBacteria" id="CCC80196">
        <property type="protein sequence ID" value="CCC80196"/>
        <property type="gene ID" value="lp_3164"/>
    </dbReference>
    <dbReference type="GeneID" id="57026459"/>
    <dbReference type="KEGG" id="lpl:lp_3164"/>
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    </dbReference>
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    <dbReference type="OMA" id="HRKTFYL"/>
    <dbReference type="PhylomeDB" id="F9UT78"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="22572" checksum="34E218C361E60B5D" modified="2011-10-19" version="1">MQVSQYQDLRVQRTINSIYDAFKRLICEKEYSKITVTELAKMAQINKKTFYRYYPTLDDLLIELQTRYSQAYLKEIGNLQYPRDLAKSVEAFFTYSATQGEAYDRITTCSVGSYVGIRQQMINEVMTKTWGQSQEFNQLADWKQRILLDFVEQTGLKVYTTWVATGKKEPLEAVISAATELMQGGVEQYLKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB4</accession>
    <name>F9UTB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642438.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3207"/>
    <dbReference type="EnsemblBacteria" id="CCC80232">
        <property type="protein sequence ID" value="CCC80232"/>
        <property type="gene ID" value="lp_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3207"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2680"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_9"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="PhylomeDB" id="F9UTB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2720-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="408" mass="45337" checksum="CDB5D6FE299E7A38" modified="2011-10-19" version="1">MKKLFANRVLNNDTSDLDEVFKNSANPENISFAGGFPDQHLFPDNDLKQAYRDAIEHDGQGIFQYSSTQGLPALRQKIADRMATHADVQVSADNVMMTQGGQQAIDLVAKLMLNHGDAMVVEGPTYMGALAAFDTYEPTYYEIPVDDNGMNIRQLRKTLKAHPEIKLIYTIPDFHNPTGTTMSAKRRQALVALANQYDVIILEDSPYRDLRYSGQNIPAIKHYDTEGRVIFISSFSKILSPALRTGWIVADDAIMHELVGLKSAIDVQSPNVTLAAINSYLDQHDIDDHVATISTSYRIKRDAMLAALDQYFPQNVHYTRPNGGFFIWVTLPEGIDAKTLLNDVVLPQAHVAYVPSACQFASRKVKNGFRLNFTSLDVETITLGIKRLGHILQPAPVIVPAASFAPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC1</accession>
    <name>F9UTC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890753.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3217"/>
    <dbReference type="EnsemblBacteria" id="CCC80239">
        <property type="protein sequence ID" value="CCC80239"/>
        <property type="gene ID" value="lp_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3217"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2687"/>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080365_3_0_9"/>
    <dbReference type="OMA" id="ATVRTIW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2727-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="23386" checksum="2AE05543416D53A9" modified="2011-10-19" version="1">MNDYLSKFNALLVQLTDDERDEVVEFYREYLLDAAIANYDDCVAELGTPKQLARKVLADYSIRFNENLNANTSKRQKSQATVRTIWLIVLALLSTPITIPALIVILAVFFALAVTVFAVVIAAGAILIGVTILAFAMLTAGIGIFGQSLWVALFYLGSGLAIIGAELLVLPLFIWLISVILQGIAKIVQNLYHRFVKKNRAERGGHHHAKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC7</accession>
    <name>F9UTC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3224"/>
    <dbReference type="EnsemblBacteria" id="CCC80245">
        <property type="protein sequence ID" value="CCC80245"/>
        <property type="gene ID" value="lp_3224"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3224"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2693"/>
    <dbReference type="eggNOG" id="COG0390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076147_1_0_9"/>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="PhylomeDB" id="F9UTC7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2733-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="251" mass="27068" checksum="910DCD2A39940725" modified="2011-10-19" version="1">MNLAVNNTSLFLAAMLVLVALGISLWQKLGLDKDIVIGVVRAVVQLFIVGYLLKYIFRVNNLWLTLAMMGFIIFNAAWNAKKRGPGIDHALAISLLAIFVSTGVTLGVLVLSGAIKFVPSQMIPISGMIASNSMVAIGLAYRSLNSQFHDQRQGVLERLALGAGLLDASIAIVREAIRTGMSPTIDSAKTVGLVSLPGMMSGLIFAGVDPVRAIKYQIMVTFMLLSATSLGSIIACYLAYRNFYNEQKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI3</accession>
    <name>F9UTI3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroneopterin triphosphate pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folQ</name>
        <name evidence="3" type="ordered locus">lp_3295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643483.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890815.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3295"/>
    <dbReference type="EnsemblBacteria" id="CCC80301">
        <property type="protein sequence ID" value="CCC80301"/>
        <property type="gene ID" value="lp_3295"/>
    </dbReference>
    <dbReference type="GeneID" id="57026563"/>
    <dbReference type="KEGG" id="lpl:lp_3295"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2751"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_9"/>
    <dbReference type="OMA" id="IQQFLPN"/>
    <dbReference type="PhylomeDB" id="F9UTI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2789-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="21293" checksum="2F9E0B6686AB0C94" modified="2011-10-19" version="1">MTTTWLIASNNAGKSRDLIACLAYYGLTARQYLTVAPRLEFPVETTTSYVDNAVAKARFGAQQLGVPVIADDSGLEISALPDLLGVTTARDLGVAVSGFDCNQEILTALRDIPDNERQALMRATLAAAWPDGRILAVQASITGYIASYQFGRYSGGFDRIFWLPRYGRTLAELPATWRIPLTHRGRAALKLITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ0</accession>
    <name>F9UTJ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug transport protein, major facilitator superfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_3303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890822.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3303"/>
    <dbReference type="EnsemblBacteria" id="CCC80308">
        <property type="protein sequence ID" value="CCC80308"/>
        <property type="gene ID" value="lp_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3303"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2759"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_9"/>
    <dbReference type="OMA" id="TQKIGYY"/>
    <dbReference type="PhylomeDB" id="F9UTJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2796-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="471" mass="51214" checksum="A3FD46380CEFD2AD" modified="2011-10-19" version="1">MQTANQNVTLTGRRRFWFIFTLLLGTWTMSISQSSLSTVYPTFMRDFGISASTVQWLTTGFMLTMVVMMPISPWLLNNIGFKKLFLAVLVLFDIGSIIIYFAPSFGVMMVGRLIKAAAVGVLFPSYQSILLTITPEEKRGSTMGVAGLVMGSALASGPIISGVVLKFTDWHGLFAVFITVATLLILISFTTIKDVMVNKPSKLDLLSIVTLLGFAGILYVVNEIGKPNVNWTFGWLLLAVSVLAVAYFTYRQFHLETPLLELRVLKTFNYDLAIFLTAISYVALIVVTIIFPLYYQGVLKVSPFVSGMSLVPGAVLLSILNPLTGKLAEKIGYKQIMLLGMSMIVVGWLILALINSELNLLTMILLAALIEGGNAFVMMPAVTLGANSLPDELISHGTAVITTVRQILGSAGVAVATLVLSNVTLAQKQAGASTLRANLQGYHTVFWMMLGIELVGLVLALLLRDGRKQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM2</accession>
    <name>F9UTM2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mutY</name>
        <name evidence="14" type="ordered locus">lp_3349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3349"/>
    <dbReference type="EnsemblBacteria" id="CCC80340">
        <property type="protein sequence ID" value="CCC80340"/>
        <property type="gene ID" value="lp_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3349"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2792"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_3_9"/>
    <dbReference type="OMA" id="RDPYRVW"/>
    <dbReference type="PhylomeDB" id="F9UTM2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2829-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="44"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC80340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="41851" checksum="505816A7A60ABF66" modified="2011-10-19" version="1">MIEWDAATIKDFQTTLLDWFDHEGRDLPWRHDHEPYHVWVSEIMLQQTQVQTVIPYYQRFMALFPTVADLAAAPESQLLKAWEGLGYYSRVRNMQRCAKQLLTDYDGQWPQTAAELTELIGIGPYTAGAIASIAFNEPVPAVDGNAYRVFSRLLKIDADIAKPQTRAAFERVISQIISQERPGDFNQAIMDLGSSYMTARQPDTAHSPVKRFNQAYLDGDELAYPVKTKKPRPKPVAYVAVLAKMQDQWLMTKRPSNGMLANLWTVPLIPIADLDLDDDYQPEELVTAVENYFKREYQLQLTAHYLTGRPVTHTFTHQKWTIQGLSGQVGLSDLAYFAGQTFTLIERQKLPMPKVQEKIFARYSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP7</accession>
    <name>F9UTP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0292"/>
    <dbReference type="EnsemblBacteria" id="CCC77817">
        <property type="protein sequence ID" value="CCC77817"/>
        <property type="gene ID" value="lp_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0292"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.245"/>
    <dbReference type="eggNOG" id="ENOG5030A4H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2382514_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-239-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="11082" checksum="66286D842FBC882C" modified="2011-10-19" version="1">MIPKSARIRIEFDAEVLRNEIFDVHDFASFQSFWQRFENFLADRMVVGHLNVLEGRGLIPSDFSDVDGHLAYQVGEDAHQIAYDQIAREWTITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ3</accession>
    <name>F9UTQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643721.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888337.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0298"/>
    <dbReference type="EnsemblBacteria" id="CCC77823">
        <property type="protein sequence ID" value="CCC77823"/>
        <property type="gene ID" value="lp_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0298"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.251"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039499_1_1_9"/>
    <dbReference type="OMA" id="YQQMVGP"/>
    <dbReference type="PhylomeDB" id="F9UTQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-245-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389140" evidence="8">
        <location>
            <begin position="42"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="341"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="492" mass="50920" checksum="6D9BAB5DFEA9BAD8" modified="2011-10-19" version="1">MNFFKRAWLNLTAKKGRSILLVLVTSAIMLFVLAGLLIRNAADTATSNAKKSVGATVTLSANREAAFKKMRSATSTSKSSRPKLTTSPVKLSDAKKIAKLSNVSSYNATVSTSANAKGFDTISTSGSSTGGGMKGMGGSSSSGTGDISITGVTNTNSVSTFESSSSKITKGRGITASDEGTNNVVIESELAKEDSLSVGDTIKLKATTGDKKTYTMKIVGIYKASSSASTQQGPGSTDVSNSVYTSYTFANTVKGSKYKNTADSVTFAISDPAKVSSVKTSGKQLINTSKYSLSTDDSSYQTVKSSMNNVKSFADKIVWLVAIAGTIILALIVILMIRERRYEIGVLLSLGESRWKIVAQFFAEMVMVLIVSVVLAGFGGKFVGNKLGDQLVSQQTTTATTTTSSTSQQGQPGGGGGAPSGNTGGSKPSGNMPSGGGQTGNASATTDTNLDINVTVMDLVELGGFGLAIMFLSIMLASGGILRLQPKKVLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ8</accession>
    <name>F9UTQ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77828.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888342.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTQ8"/>
    <dbReference type="STRING" id="220668.lp_0304"/>
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        <property type="gene ID" value="lp_0304"/>
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    <dbReference type="HOGENOM" id="CLU_077123_0_0_9"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394427" evidence="2">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC77869">
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        <property type="gene ID" value="lp_0350"/>
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    <dbReference type="KEGG" id="lpl:lp_0350"/>
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    <dbReference type="eggNOG" id="COG0039">
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="entry name" value="L-lactate/malate_DH"/>
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        <property type="entry name" value="Lactate/malate_DH_N"/>
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldh_1_N"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LLDHDRGNASE"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
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        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
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        <ligand>
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        <ligand>
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    </feature>
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        <ligand>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    <sequence length="319" mass="34819" checksum="7EDCD6533E34040F" modified="2011-10-19" version="1">MRKYAIIGVGHVGATIAYTLVCKGIADELVLIDTNAAKARAEQLDLQDAQARLDSRTIIKINDYHELDDTDILFVTSGNIHALDHASGNRWAEFEYTKQIVQDIAPKVKATKFNGVVIDTMNPCDAITHYFQRATGLSRQQVFGTGTFLDTARMQKVVAEAFDCDPKNISGYVYGEHGESQFSAWSTVQVNGIPITSLVDKYHLDLDALEAAARHGGWAVHSGKGYTSFAIATCAVKLSEAVFANARLACPVSAYSETFETYVGQPAIIGKDGVESVTTLALTADEQAKFRNSADTIIEKFHAFDDVLSDQSVKKRQQA</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77877.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="gene ID" value="lp_0360"/>
    </dbReference>
    <dbReference type="GeneID" id="57027168"/>
    <dbReference type="KEGG" id="lpl:lp_0360"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.304"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_3_9"/>
    <dbReference type="PhylomeDB" id="F9UTV7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-299-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17448" checksum="84CA6D6192CC50FB" modified="2011-10-19" version="1">MKLDFSVAVHSILYLDAHRDSKVASRELAQSLHLNPVMIRNILSVLHKHGYLTGTVGKNGGYQLDLALADMNLGDLYDLTIPPTISYARFITGPSKTDEQADQSPIAANISETLTDLFTVADRQYRAYYHQFTMADLQADLNHHGTFLQHEQDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV8</accession>
    <name>F9UTV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888392.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0361"/>
    <dbReference type="EnsemblBacteria" id="CCC77878">
        <property type="protein sequence ID" value="CCC77878"/>
        <property type="gene ID" value="lp_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0361"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.305"/>
    <dbReference type="eggNOG" id="ENOG5030A1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155817_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-300-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="16958" checksum="E74AB162A2EAB249" modified="2011-10-19" version="1">MKNKAIFVNNLNLKRVCHSGLSGLIIGAILDVIMKVALRLKGALAMTARLVLIHEVGRYRELSEQRYWLESADFWGVDGRGATVNEAIGNFLTNLVQYCRDYYQRGLWQLDDRLLQLDHVDTVLAYAQAGKSPAPLFLFKLVPADHELASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY2</accession>
    <name>F9UTY2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imm63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888416.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77902">
        <property type="protein sequence ID" value="CCC77902"/>
        <property type="gene ID" value="lp_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0388"/>
    <dbReference type="eggNOG" id="ENOG5033378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1883134_0_0_9"/>
    <dbReference type="OMA" id="HGSEDGF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-325-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028952">
        <property type="entry name" value="Imm63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15599">
        <property type="entry name" value="Imm63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Imm63" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="15831" checksum="B5F674CBB0B79654" modified="2011-10-19" version="1">MFKLSTEDLKIYILERVSRLGNINIKEYNFLENKHGSEDGFYIYSDGQRYHFVYSERGTENKHNVTDNLFEIAYWVISSITDTLAIRYVRTRVLPNQSQRKIIFDKKLSLLSIVGENYKKAGEIEISEILKTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY3</accession>
    <name>F9UTY3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888417.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77903">
        <property type="protein sequence ID" value="CCC77903"/>
        <property type="gene ID" value="lp_0391"/>
    </dbReference>
    <dbReference type="GeneID" id="57024202"/>
    <dbReference type="KEGG" id="lpl:lp_0391"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.325"/>
    <dbReference type="eggNOG" id="ENOG5030B9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187595_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-326-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="10326" checksum="D539F9A9F7849723" modified="2011-10-19" version="1">MLVFIVIGLITAVITIGLGYWSYILGKRNKSNLVGSVIPVGYFIVRLVFVLVLGEGVRELITSLVGNLVITAIYVLLFVWGRQRFNRQKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU03</accession>
    <name>F9UU03_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-componet system histidine protein kinase PlnB sensor protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="3" type="primary">plnB</name>
        <name evidence="3" type="ordered locus">lp_0416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100998.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU03"/>
    <dbReference type="STRING" id="220668.lp_0416"/>
    <dbReference type="EnsemblBacteria" id="CCC77923">
        <property type="protein sequence ID" value="CCC77923"/>
        <property type="gene ID" value="lp_0416"/>
    </dbReference>
    <dbReference type="GeneID" id="57024219"/>
    <dbReference type="KEGG" id="lpl:lp_0416"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.339"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046138_1_2_9"/>
    <dbReference type="OMA" id="YNEICSE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-345-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="NatK_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="183"/>
        </location>
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        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
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            <end position="437"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="442" mass="50436" checksum="C120C89E797D1CE3" modified="2011-12-14" version="1">MVEISIFDSVIQSFFIYLGIILVYNFIFSNTNIKRIIYSLILLLVLSLVGAILDDTTSLILVLGAIIKEKCQPKINYYHLNVFLMLISSQIVILALASYLSRGFLYIYLDADKISGLSEYGDLFIGIEIIVMYIIGFLVFNLVYKMVRRYTGSFDISDDERINRHLFIILLAFFGSIEMLLFISNFQGVTATIQLTLLLTFVLMLGLISWQTLETIRVYAWQKKIAAEKLQNKQLNDYLKSVEHQYLELRKFKHDYKNLIASLNTQDNISEIKDYLTDYTQSGEFRASLNDGSIASVQHLKNEILRGLVVQKFFYAKQCGVKLTIEIANTDFILSHGVTVAVRIIGNLLDNAIEQAQKMTDKIVTVAFNEIDNTAEIAISNPIDSDFNQHQIFETGYSTKGSNRGLGLTNVRDLVEQQKGFYMDIETKKNYVTMTLIVTEDK</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890884.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3385"/>
    <dbReference type="EnsemblBacteria" id="CCC80370">
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        <property type="gene ID" value="lp_3385"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3385"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2821"/>
    <dbReference type="eggNOG" id="ENOG5030B21">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="142" mass="15273" checksum="18029B5F1D2518C2" modified="2011-10-19" version="1">MGKPIYELSKLNDISKACKQAAITIERVNVANASISAISELVTPTLKQAITGDDNVNYFELNDDELRDFIDEQGNTIYNTMCVLTEMDELSALIDSKTAALSGVIGDINSTVNGINDSINSVFDGGNSDYSDDNSQGATDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC3</accession>
    <name>F9UUC3_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Cell surface protein, CscC family</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_3450</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102168.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3450"/>
    <dbReference type="EnsemblBacteria" id="CCC80425">
        <property type="protein sequence ID" value="CCC80425"/>
        <property type="gene ID" value="lp_3450"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3450"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2873"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024308_0_0_9"/>
    <dbReference type="OMA" id="NEIELWA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2913-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394344" evidence="1">
        <location>
            <begin position="28"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="716" mass="77386" checksum="DB850CE3AE0673EB" modified="2011-10-19" version="1">MWKGPKQILVALTALMGLWAGTAQIQAADEATLATAPSGLNQLDKLFTLPAAFSSGISNSANIGNVTNASSPNTQAVQVINGKKQMGGFWSNDANRLDLNKNATFKMWVYLGTSTSTSKAGDGMAFVLQNDPNGTAASAQVSSSSIIGETLGVWGVDTDNKLKDGEEFAKTAIQNSWALEFDTYTNTSTSYSNAGKGDSFDDGIKKQHIATGYPGLASQYENQSVRSLDVTGIIWSTRYYFTQKHTNLVTNMSLGDSKWHHLVMDWHAATKTMTYTYNDINPDGSATGSGFTQSEVLDTSQFNSSDGLVRWGFMGATGSNSGNNMVVIESAPNLVDVHAAVKVTDKTKNREIKTGGQLKAQHKVQYDYQLTYQGGQIDWDNITAELNLPQHITFDSAKVTYADGSEQTLTAPTSSDTKVDYTLDKAVSASQPTATITLNGTAENVVVNEQTTATTATFKNKVFETTTEAPDYMITVDQPLYLKIRNSPYTVANGEDVIIRGIVAAEDSEQLTNGQVTLHPTLNGKEMPTVQMSDDDEQGYFYYKVKAEDLHVGDDNEIELWASDRYENVSPVDKAQIIVTAGELGFKTVAKSSTFKTITLDGSAQTTDREDDWQLVVRDSRGKGSSWQLQASATNFKTTGGQNLAGDVIFRDGEQTTTLNSAGTVIDSHTATSDNDDYDVLADWTNKSGILYQSNAGATPGSYTGDITWTLTDAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF5</accession>
    <name>F9UUF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890971.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3489"/>
    <dbReference type="EnsemblBacteria" id="CCC80457">
        <property type="protein sequence ID" value="CCC80457"/>
        <property type="gene ID" value="lp_3489"/>
    </dbReference>
    <dbReference type="GeneID" id="66450955"/>
    <dbReference type="KEGG" id="lpl:lp_3489"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2905"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_9"/>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="PhylomeDB" id="F9UUF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2945-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="37933" checksum="77A002D3775B2E61" modified="2011-10-19" version="1">MYQASQKRYDHMIYNRVGNSGLKLSAIGLGLWNNFGSVDPIANQKAIIHQAFDLGITYYDLANNYGPEPGSAETNFGRIMATDMRPYRDEMVIASKAGYVMWPGPYGNWGSRKSIIASADQSLQRTGLDYFDIFYSHRPDPETPMEETATALDQLVRQGKTLYVGISNYNGKQTAAMTKIFESLGTPYIIHQPRYNMFNRQVEQDLFPVLQATHKAAVGFSSLSQGLLTDKYLHGITTDSRANKQTIPFLSPVQVEQTLATVKRLNEVAQQREQSLAQMALAWNLRQPALASVLIGASRPEQVVNNVAALEKLKFSESELATIEQILTEQPAIDWNAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ7</accession>
    <name>F9UUJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891013.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80499">
        <property type="protein sequence ID" value="CCC80499"/>
        <property type="gene ID" value="lp_3535"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3535"/>
    <dbReference type="HOGENOM" id="CLU_2617603_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2987-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="78" mass="9128" checksum="4FAE0220922EB1F6" modified="2011-10-19" version="1">MAGIAVNMTLDDISYHVKLDGKLGLIDRKHNSYEMLEIPTKIHFYQILYDHVLNKGINLSDWIDIKILLTSLFRKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ9</accession>
    <name>F9UUJ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891015.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3537"/>
    <dbReference type="EnsemblBacteria" id="CCC80501">
        <property type="protein sequence ID" value="CCC80501"/>
        <property type="gene ID" value="lp_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3537"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2948"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_9"/>
    <dbReference type="OMA" id="DITMIEY"/>
    <dbReference type="PhylomeDB" id="F9UUJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2989-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="30082" checksum="95B6D9907F961EF9" modified="2011-10-19" version="1">MENIKMIAIDIDGTLVNSKKQVTLRVKQAIKMAKKKKIKVVICTGRPLTGVKALLQELELDAQDDQYVVCFGGAATYTTSGELIDERPISYEDYIDLEALARKLRLHFHTVSEDRLYTADRNIGDYTLYEANLVSMGISYRTPEEMRNIKLIKSMYVDEPEVLDAAIKQQKLFEPLKKQVTFTKSAPFYYEANANGVSKGNALQVLCEKLSLTAANVMAIGDEANDLSMIKFAGHGVAMGNAIPEVKQVADEITVDNEHDGVAKAIEAITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK3</accession>
    <name>F9UUK3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, lactose/cellobiose-specific EIIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pts34B</name>
        <name evidence="3" type="ordered locus">lp_3541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642903.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891019.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3541"/>
    <dbReference type="EnsemblBacteria" id="CCC80505">
        <property type="protein sequence ID" value="CCC80505"/>
        <property type="gene ID" value="lp_3541"/>
    </dbReference>
    <dbReference type="GeneID" id="66450988"/>
    <dbReference type="KEGG" id="lpl:lp_3541"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2952"/>
    <dbReference type="eggNOG" id="COG3414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159248_0_1_9"/>
    <dbReference type="OMA" id="PTAADVW"/>
    <dbReference type="PhylomeDB" id="F9UUK3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2993-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="10852" checksum="0C8A488D59FDC7F7" modified="2011-10-19" version="1">MKFLAVCQSGLGSSFMVQMNIQSILKDENVKEDIQVDHSDVGSVGADSADYFFVESTLQSALGSIPENKVVLLKSLIDKQEVRNHVNTILDQENIEHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O08445</accession>
    <accession>F9UKZ8</accession>
    <name>ALR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine racemase</fullName>
            <ecNumber evidence="1">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">alr</name>
        <name type="ordered locus">lp_0523</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="3804" last="3807">
            <title>The alanine racemase gene is essential for growth of Lactobacillus plantarum.</title>
            <authorList>
                <person name="Hols P."/>
                <person name="Defrenne C."/>
                <person name="Ferain T."/>
                <person name="Derzelle S."/>
                <person name="Delplace B."/>
                <person name="Delcour J."/>
            </authorList>
            <dbReference type="PubMed" id="9171436"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="Y08941">
        <property type="protein sequence ID" value="CAA70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08445"/>
    <dbReference type="SMR" id="O08445"/>
    <dbReference type="STRING" id="220668.lp_0523"/>
    <dbReference type="PRIDE" id="O08445"/>
    <dbReference type="EnsemblBacteria" id="CCC78013">
        <property type="protein sequence ID" value="CCC78013"/>
        <property type="gene ID" value="lp_0523"/>
    </dbReference>
    <dbReference type="GeneID" id="57024294"/>
    <dbReference type="KEGG" id="lpl:lp_0523"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.431"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_1_9"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="PhylomeDB" id="O08445"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-434-MON"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114528" description="Alanine racemase">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <sequence length="375" mass="40710" checksum="844E9BAC5FF3463B" modified="1997-07-01" version="1">MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAGATGFCVAILDEALALRAAGFAEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAILAANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQPQSPFDFEGIFTHFATADQADDTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGRELSAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGFHVLVDGEFCEIVGRVCMDQLMVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYEIACGLAPRVPRVYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE3</accession>
    <name>Q6LWE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traC</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222041.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133748.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723584"/>
    <dbReference type="EnsemblBacteria" id="CAG17865">
        <property type="protein sequence ID" value="CAG17865"/>
        <property type="gene ID" value="CAG17865"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17865"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3112"/>
    <dbReference type="eggNOG" id="ENOG5033WZQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046644_0_0_9"/>
    <dbReference type="OMA" id="IFIAIPP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3165-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13880" checksum="516CAAD8297934BB" modified="2004-07-05" version="1">MKKGKEFIFPENVDKDYGIWKDYTLKDFGYAALAGLVGLIFIAIPPYGLILVLIKIVIVVLAMTIVMAILTIRPVASRKNIKVRDNFKLKRRYANSQKLFYLKPKKRGELNAFEEEQDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG6</accession>
    <name>Q6LWG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Repressor of arsenical resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arsD1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222021.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133725.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723561"/>
    <dbReference type="EnsemblBacteria" id="CAG17842">
        <property type="protein sequence ID" value="CAG17842"/>
        <property type="gene ID" value="CAG17842"/>
    </dbReference>
    <dbReference type="GeneID" id="57295598"/>
    <dbReference type="KEGG" id="lpl:CAG17842"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3091"/>
    <dbReference type="eggNOG" id="ENOG5032RMG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120868_1_0_9"/>
    <dbReference type="OMA" id="FEPELTC"/>
    <dbReference type="PhylomeDB" id="Q6LWG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3142-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010712">
        <property type="entry name" value="Arsenical-R_ArsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06953">
        <property type="entry name" value="ArsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="12585" checksum="AD1EBF7A6B2C5BC8" modified="2004-07-05" version="1">MKKIELFEPAMCCSTGVCGPSVDQNLLMITSAFDALQGVKTIEADRYNLSNNPDVFSERADILAAIKDDADAVLPITVVDGQIVKTGAYPTIDELSDYTGLVFVPAEQTGGCCGGDGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG9</accession>
    <name>Q6LWG9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133722.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723558"/>
    <dbReference type="EnsemblBacteria" id="CAG17839">
        <property type="protein sequence ID" value="CAG17839"/>
        <property type="gene ID" value="CAG17839"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17839"/>
    <dbReference type="HOGENOM" id="CLU_2788719_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3139-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="68" mass="7556" checksum="E3B7A0CDD71B0028" modified="2004-07-05" version="1">MRLPNKSKSLTTRNRHSKANGLMRKLLLLPGEVCHGSSLKLEVISGRNRLNSNVELSMTEVSRGHSSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S98</accession>
    <accession>F9UUK1</accession>
    <name>TAL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transaldolase</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tal</name>
        <name type="ordered locus">lp_3539</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891017.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S98"/>
    <dbReference type="SMR" id="Q88S98"/>
    <dbReference type="STRING" id="220668.lp_3539"/>
    <dbReference type="EnsemblBacteria" id="CCC80503">
        <property type="protein sequence ID" value="CCC80503"/>
        <property type="gene ID" value="lp_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3539"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2950"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_9"/>
    <dbReference type="OMA" id="FRIQHID"/>
    <dbReference type="PhylomeDB" id="Q88S98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2991-MON"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173668" description="Probable transaldolase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <sequence length="217" mass="23260" checksum="237AE07377A1E29A" modified="2003-06-01" version="1">MKFFLDTANTEDIKHFAELGLVDGVTTNPTLVSREGRDFETVIKEITQIVSGPVSAEVTATKAEEMIAQARNEIKWASNIVVKIPMTEEGLKAVKVLSGEGIKTNVTLVFSVSQGLLAAKAGATYISPFLGRLDDIGGNGIQLVKDLRQVLDTYGFKTEIIAASVRGPQHVQEAALAGADIATIPATVFGKLWSHPLTDKGLASFASDWKAFQATQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SF0</accession>
    <accession>F9UUE6</accession>
    <name>GALT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="1">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">galT</name>
        <name type="ordered locus">lp_3480</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102180.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SF0"/>
    <dbReference type="STRING" id="220668.lp_3480"/>
    <dbReference type="PRIDE" id="Q88SF0"/>
    <dbReference type="EnsemblBacteria" id="CCC80448">
        <property type="protein sequence ID" value="CCC80448"/>
        <property type="gene ID" value="lp_3480"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3480"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2896"/>
    <dbReference type="eggNOG" id="COG4468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047799_0_0_9"/>
    <dbReference type="OMA" id="IVDWPMS"/>
    <dbReference type="PhylomeDB" id="Q88SF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2936-MON"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023425">
        <property type="entry name" value="GalP_uridyl_Trfase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01239">
        <property type="entry name" value="galT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01163">
        <property type="entry name" value="GAL_P_UDP_TRANSF_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0299">Galactose metabolism</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000169910" description="Galactose-1-phosphate uridylyltransferase">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <sequence length="487" mass="54243" checksum="70748FD7C6277E8B" modified="2003-06-06" version="1">MTSLDQFVTAVIASPSQYTELDRIYVHNRVLGLVGEGDPIAASDDQLTSLTDALVKTAIQNGKIEATQSDEDILADQLMDLVTPLPSVLNQRFWDKYQVSPQTATDYFFNLSKANDYIKTRAIAKNVVFPAKTPFGDLEITINLSKPEKDPKAIAAARNQPQDGYPLCQLCMQNEGYLGRLGYPARSNHRIIRLTLGGNTWGFQYSPYAYFNEHSIFLDQEHRPMVINRQTFTNLLEIVQQFPHYFVGSNADLPIVGGSMLSHEHYQGGRHEFPMMKAPIARTIDLGIAGVKAGIVKWPMSTIRLTSQDLVALTDAAVKIHETWKNYSDESVDVRAYTDGTRHHTTTPIARKVGDDYVLDIVLRDNQTSAEFPDGIFHPHQDVQHIKKENIGLIEVMGRAILPARLKTELAEVGKYLLDQPNQMVAMHQAWAAQLKATNTITADNVTTVIDTAVGNVFARVLADAGVFKWDDAGEAAFDRFVAAMHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SY9</accession>
    <accession>F9UTC9</accession>
    <name>Y3226_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized RNA methyltransferase lp_3226</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_3226</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642454.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890761.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SY9"/>
    <dbReference type="SMR" id="Q88SY9"/>
    <dbReference type="STRING" id="220668.lp_3226"/>
    <dbReference type="PRIDE" id="Q88SY9"/>
    <dbReference type="EnsemblBacteria" id="CCC80247">
        <property type="protein sequence ID" value="CCC80247"/>
        <property type="gene ID" value="lp_3226"/>
    </dbReference>
    <dbReference type="GeneID" id="57026510"/>
    <dbReference type="KEGG" id="lpl:lp_3226"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2695"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_1_9"/>
    <dbReference type="OMA" id="YCGVGGF"/>
    <dbReference type="PhylomeDB" id="Q88SY9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2735-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000161990" description="Uncharacterized RNA methyltransferase lp_3226">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="481" mass="53727" checksum="DC22FCE3311948A8" modified="2003-06-01" version="1">MPQSNHYSHQSRSHNDRRRQQPDEKVQATVNIGQRFPLTIRRLGINGEGIGYYKHVITFVKGALPEEVVVAEVTAVHPRYLEAKIRSIRKPSPDRVDPRDAYAGEVGGFELEHLDYPAQLAFKQDLIRQALEKYRPAGYRHYDVRPTIGMTNPYEYRNKAQFQVRLIDGHVAAGLYKENSHDLVDLPTCSVQMPATMTVMRQVVAWLEELQVPIYDEEHNSGIVKTIVVREAAATGEIQLVFITNTPKLPKKHQLLMKIAEKLPMVVSVMQNINAGKTSLIWGDQTTLLAGKPTITEELDGLVFDLSARAFFQLNPQQTKKLYRLAREALNLAPNETLVDAYSGVGTIGLSLADVAKEVRGMDTIPAAVADANANAQRNQITNAHYEVGEAEVLLPQWLASGFAPDAMVVDPPRTGLDNVLIDAILQSAPEKLVYISCNPSTLAQDLQALTRGYQVDYIQSIDMFPQTARCEAVVRFTKRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q88TT1</accession>
    <accession>F9URU4</accession>
    <name>Y2841_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>UPF0324 membrane protein lp_2841</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2841</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890447.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88TT1"/>
    <dbReference type="STRING" id="220668.lp_2841"/>
    <dbReference type="EnsemblBacteria" id="CCC79933">
        <property type="protein sequence ID" value="CCC79933"/>
        <property type="gene ID" value="lp_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2841"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2375"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_3_0_9"/>
    <dbReference type="OMA" id="IIVKMIR"/>
    <dbReference type="PhylomeDB" id="Q88TT1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2430-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000157424" description="UPF0324 membrane protein lp_2841">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="336" mass="35136" checksum="8A4E2FDF2EB3EAB6" modified="2003-06-01" version="1">MKVKGILPGLVTSLVIAIISQGLAQFVPALGAATIAILLGIIGGNTFLKQPQLGRGTKFAESKLLEYSVMLLGATMTVQTIGKIGGFGVLFILCQMTITIVGALWLGRKLGFSQSVRMLMAGGNAVCGSSAIASIAPVIDADEDDKGTVITLVNLMGTVLMLTLPVLGMAVFGGSVILKGALIGGTLQSVGQVVAAASMINQTTVQFATIFKIMRIMMLVVVVLIFGRLHQRTIENELAEDAVVSGNGNGHWLPWYVAGFLILCALNSLISLPAIIGATAHTISSWFEIIALAAIGLRLNLVNFMKAGKRLALYGLGVGTIQVVSALILITLLLQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UC0</accession>
    <accession>F9UR95</accession>
    <name>FENR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="1">FNR</shortName>
            <shortName evidence="1">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="1">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2585</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UC0"/>
    <dbReference type="SMR" id="Q88UC0"/>
    <dbReference type="STRING" id="220668.lp_2585"/>
    <dbReference type="EnsemblBacteria" id="CCC79734">
        <property type="protein sequence ID" value="CCC79734"/>
        <property type="gene ID" value="lp_2585"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2585"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2170"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_5_9"/>
    <dbReference type="OMA" id="PEKVIYD"/>
    <dbReference type="PhylomeDB" id="Q88UC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2225-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364857" description="Ferredoxin--NADP reductase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <sequence length="331" mass="36077" checksum="81D714D63B77E503" modified="2003-06-01" version="1">MSAEYDLTIIGGGPVGMFAAFYAGMRNARVQLLESLPELGGQVQALYPEKIIHDVAGYPAIKGRELVAQLEKQLTQFPIDIQLASPVTDVTGAMGDFTITTASGQQSHSKAIIVATGSGAFEPRRLAVDNAAEFENKQLFYHIPSVKQFADRTVLVAGGGDSAIDMALMLEPVAKHVYIMHRRDRFRGMEHNVDLLKASSVEIKTPFLIKQLAETATGQLQLTMKEVRGTTEETLAVDDLIVNYGFIADNKVIRNWHVTPTMAHRLITVDTEMNTDVPGIAAIGDTVTYAGKLGLIASGFGEAPNAVNQLMMTLYPERRSPLHSTTVFEKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VG4</accession>
    <accession>F9UQ41</accession>
    <name>OBG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">lp_2094</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644566.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889844.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VG4"/>
    <dbReference type="SMR" id="Q88VG4"/>
    <dbReference type="STRING" id="220668.lp_2094"/>
    <dbReference type="EnsemblBacteria" id="CCC79330">
        <property type="protein sequence ID" value="CCC79330"/>
        <property type="gene ID" value="lp_2094"/>
    </dbReference>
    <dbReference type="GeneID" id="57025637"/>
    <dbReference type="KEGG" id="lpl:lp_2094"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1771"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_9"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="PhylomeDB" id="Q88VG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1791-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385999" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="3">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="2">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <sequence length="431" mass="46685" checksum="0F06BC254504C534" modified="2003-06-01" version="1">MFVDQVKVDVKAGNGGNGMVAFRREKFVPNGGPAGGDGGRGGSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGRSAKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLADVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVILHLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLATDDTLPNTPAVYPVSSITQQGLKALLAKTADLLDTTPQFPIKGVDDLKHRDYTTEADADFSIDNPEPGLFVLSGDKLERLFKMTNLDHEESLMRFARQLRGMGVDDALRAAGAKNDDTIQILDYSFQFMD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-28" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VI7</accession>
    <accession>F9UQ17</accession>
    <name>Y2062_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein lp_2062</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2062</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889820.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VI7"/>
    <dbReference type="SMR" id="Q88VI7"/>
    <dbReference type="STRING" id="220668.lp_2062"/>
    <dbReference type="EnsemblBacteria" id="CCC79306">
        <property type="protein sequence ID" value="CCC79306"/>
        <property type="gene ID" value="lp_2062"/>
    </dbReference>
    <dbReference type="GeneID" id="57025612"/>
    <dbReference type="KEGG" id="lpl:lp_2062"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1747"/>
    <dbReference type="eggNOG" id="COG4224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173137_0_1_9"/>
    <dbReference type="OMA" id="KMARINE"/>
    <dbReference type="PhylomeDB" id="Q88VI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1767-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094975" description="UPF0291 protein lp_2062">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <sequence length="79" mass="9387" checksum="059C0AB95024F232" modified="2003-06-01" version="1">MISKELLARINELAHKAKAEGLTELEEAERQELRQKYLKEFRAGFRQQVEMLQVYDKDGKEVTPEKVRQVQRDRGLRDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ1</accession>
    <accession>F9UQ13</accession>
    <name>Y2058_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>UPF0213 protein lp_2058</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2058</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0213 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640742.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ1"/>
    <dbReference type="SMR" id="Q88VJ1"/>
    <dbReference type="STRING" id="220668.lp_2058"/>
    <dbReference type="EnsemblBacteria" id="CCC79302">
        <property type="protein sequence ID" value="CCC79302"/>
        <property type="gene ID" value="lp_2058"/>
    </dbReference>
    <dbReference type="GeneID" id="57025608"/>
    <dbReference type="KEGG" id="lpl:lp_2058"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1743"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_0_3_9"/>
    <dbReference type="OMA" id="RLYTGIT"/>
    <dbReference type="PhylomeDB" id="Q88VJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1763-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161365" description="UPF0213 protein lp_2058">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="101" mass="11450" checksum="C1A59E825B57BA8E" modified="2003-06-01" version="1">MASTSKPAASTTAIKKYYFYVLLCADQTLYGGFTDNLQRRLATHNAGKGAKYTRVRSRRPLQLIYHETFTDKSSALKAEYAFKHQSRAAKLKYLSAHDVKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WM9</accession>
    <accession>F9UNX3</accession>
    <name>NUSB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">lp_1598</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101470.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889426.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WM9"/>
    <dbReference type="SMR" id="Q88WM9"/>
    <dbReference type="STRING" id="220668.lp_1598"/>
    <dbReference type="EnsemblBacteria" id="CCC78912">
        <property type="protein sequence ID" value="CCC78912"/>
        <property type="gene ID" value="lp_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1598"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1347"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_2_9"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="PhylomeDB" id="Q88WM9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1374-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176548" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15758" checksum="D027A49B9C7309BF" modified="2003-06-20" version="1">MSLTRHEIREKAFQALFALNANPDADENQLFQQLLNPEETDAVEIPAYLSTLVTGVREHQVELDAQIQPYLSQKWSLDRLAKTDLIILRIAFFELQFVDDVPTKVAVNEAIELTKAFSDDRSRKFVSGVLGKVVKNQAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YL7</accession>
    <accession>F9ULW7</accession>
    <name>SECA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">lp_0739</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YL7"/>
    <dbReference type="SMR" id="Q88YL7"/>
    <dbReference type="STRING" id="220668.lp_0739"/>
    <dbReference type="PRIDE" id="Q88YL7"/>
    <dbReference type="EnsemblBacteria" id="CCC78206">
        <property type="protein sequence ID" value="CCC78206"/>
        <property type="gene ID" value="lp_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0739"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.622"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_2_9"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="PhylomeDB" id="Q88YL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-641-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000073483" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <sequence length="787" mass="89558" checksum="D97CE603A4294E50" modified="2003-06-01" version="1">MANILKRWVESDKRTIRRLDKIANKVEAYADEYGKLSDADLQAKTPEFRERYKEGESLDDLLPEAFATAREGAKRVLGLYPFHVQILGGIVLHQGDIAEMKTGEGKTLTATMPVYLNAISGKGVHVVTVNEYLSARDATEMGELYNWLGMSVGINGAEKSPEEKRAAYNADITYSTNGEIGFDYLRDNMVVYREDMVQRPLNFAIIDEVDSILIDEARTPLIISGQSEGTTGMYKRADRFAKTLTKDEDYKVDLESKTVALLDEGIRKAEKYFGLENLYDTDNTALNHYLDEALRANYIMLKDKDYVISDGQALIVDSFTGRIMDGRRFSDGLHQAIEAKEHVEIQEETKTMANITYQNLFRMYKKLSGMTGTAKTEQEEFREIYNMEVITIPTNRPMIRDDRSDLLYPTLQSKFNAVVKEIKQLHEKGQPMLIGTVAVETSEYLSHRLDEENIPHVVLNAKNHAKEADIVANAGQRGAVTIATNMAGRGTDIKLGPGVKEVGGLAVIGTERHESRRIDNQLRGRAGRQGDPGMSQFYLSLEDDLMLRFGSERIKNFLQRMNVEDDDAVIQSRMITRQVESAQKRVEGNNYDSRKNVLQYDDVMRAQREVIYGERQQVIMEEKSLKPVIMPMIKRTVERTVQLHMQGDAKDWDLDAVVDFAQAAMVKEDSISVADLKGKSPAEVEAYLMDRVDKIYADKAKQLYDAGQMLEFEKVVILRVVDSHWTDHIDAMDQLRQSIGLRGYGQLNPLVEYQRDGYQMFEEMVADIDYDTTRLFMKSEIRQNIQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YP8</accession>
    <accession>F9ULT6</accession>
    <name>RECR_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">lp_0700</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888689.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YP8"/>
    <dbReference type="SMR" id="Q88YP8"/>
    <dbReference type="STRING" id="220668.lp_0700"/>
    <dbReference type="EnsemblBacteria" id="CCC78175">
        <property type="protein sequence ID" value="CCC78175"/>
        <property type="gene ID" value="lp_0700"/>
    </dbReference>
    <dbReference type="GeneID" id="57024410"/>
    <dbReference type="GeneID" id="66448678"/>
    <dbReference type="KEGG" id="lpl:lp_0700"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.588"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_9"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="PhylomeDB" id="Q88YP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-610-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000190336" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="199" mass="21879" checksum="F63914C95C30D57E" modified="2003-06-01" version="1">MQYPEPIAKLIDSYMKLPGIGGKTATRLAFYTIDMNGDDVTEFAKSLIAAKRDLHFCSICGNITEDDPCVICKDKSRDQSTVLVVEEAKDVMAMEKIKEYNGLYHVLHGVLSPIDGKGPEDINIASLLKRLQQNEAIKEVIIATNATPEGEATAMYISRLVKPAGIKVTRLAHGLSVGSDIQYADEMTLFKAVEGRQEM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YW9</accession>
    <accession>F9UL85</accession>
    <name>RL1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">lp_0620</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888614.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YW9"/>
    <dbReference type="SMR" id="Q88YW9"/>
    <dbReference type="STRING" id="220668.lp_0620"/>
    <dbReference type="PRIDE" id="Q88YW9"/>
    <dbReference type="EnsemblBacteria" id="CCC78100">
        <property type="protein sequence ID" value="CCC78100"/>
        <property type="gene ID" value="lp_0620"/>
    </dbReference>
    <dbReference type="GeneID" id="57024395"/>
    <dbReference type="GeneID" id="66448662"/>
    <dbReference type="KEGG" id="lpl:lp_0620"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.520"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_9"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="PhylomeDB" id="Q88YW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-531-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125672" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="229" mass="24770" checksum="DD98E725697C3244" modified="2003-06-01" version="1">MAKKSKQYQDAAKLVDRDKAYDVTEAVDLVKKMDFAKFDATVEVAFKLNVDTKQADQQLRGAVVLPNGTGKDQTVIVFAKGDKAKEAEEAGADFVGETDLVQKIQDGWLDFDVAIATPDMMAQVGRLGRVLGPKGLMPNPKTGTVTMDVAKAVNDSKAGKVTYRTDRDGNVHVPVGKVSFDTDKLVGNFKTIEDTIVKARPASVRGTFIQNLVVTSTFTPAVRVDLASF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-27" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z02</accession>
    <accession>F9UL49</accession>
    <name>PAND_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">panD</name>
        <name type="ordered locus">lp_0579</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z02"/>
    <dbReference type="SMR" id="Q88Z02"/>
    <dbReference type="STRING" id="220668.lp_0579"/>
    <dbReference type="EnsemblBacteria" id="CCC78064">
        <property type="protein sequence ID" value="CCC78064"/>
        <property type="gene ID" value="lp_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0579"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.482"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_9"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="PhylomeDB" id="Q88Z02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-495-MON"/>
    <dbReference type="BRENDA" id="4.1.1.11">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000023111" description="Aspartate 1-decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000023112" description="Aspartate 1-decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <sequence length="130" mass="14458" checksum="813A76450299104D" modified="2003-06-01" version="1" precursor="true">MLIDMLKGKIHRATVTQADLEYVGSITIDETLMEASGILEYEKVQIADVNNGARFETYVIAGPRDSGVICLNGATARCASVGDKVIIMNYAQFEPEEAKHAKPYVVLVDDENRLTKRVRYEKHGLLAEEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z28</accession>
    <accession>F9UL23</accession>
    <name>SYK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="1">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysS</name>
        <name type="ordered locus">lp_0550</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888552.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z28"/>
    <dbReference type="SMR" id="Q88Z28"/>
    <dbReference type="STRING" id="220668.lp_0550"/>
    <dbReference type="EnsemblBacteria" id="CCC78038">
        <property type="protein sequence ID" value="CCC78038"/>
        <property type="gene ID" value="lp_0550"/>
    </dbReference>
    <dbReference type="GeneID" id="57024324"/>
    <dbReference type="KEGG" id="lpl:lp_0550"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.456"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_9"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="PhylomeDB" id="Q88Z28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-459-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152639" description="Lysine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <sequence length="499" mass="57629" checksum="BC26C96489E9CE7E" modified="2003-06-01" version="1">MARQEQTMNDQLKVRREKMDELREEGIDPFGHRFERTDLAQDLQDKYGDMDKDELDAKQVVATIAGRMLAKRGKGKVGFADIWDRSGKMQLYIRKDVVGEDTYHIFKRSDIGDFLGITGQVFKTDFGELTIKVTGLTFLSKALRPLPDKFHGLQNVEQIYRQRYLDLISNRDSFDRFLKRTKIISAIRHHLDDQGFTEVETPMLHNQAGGAAARPFVTHHNALNIDLYLRIALELHLKRLIVGGMEKVYEIGRVFRNEGMDREHNPEFTMMETYVAYFDFHDVMAETEGIFKAAAQAVTDDGIVTYHDQKVDFNQPFKQIHMVDAIKEKTGIDFWQPMSIEDAQKLADEHHVKYEPYWKVGHIINAFFEEFVEDTLNEPTFVYGHPVEISPLAKKNEEDPRFTDRFELFILGNEYANAFSELNDPIDQRQRFEAQAAERTAGNDEAEHIDEDFVEALEYGMPPTGGLGIGIDRLVMLMTDADSIRDVLLFPTMRPEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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    <name>F9UL15_LACPL</name>
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        </submittedName>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
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            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888544.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0541"/>
    <dbReference type="EnsemblBacteria" id="CCC78030">
        <property type="protein sequence ID" value="CCC78030"/>
        <property type="gene ID" value="lp_0541"/>
    </dbReference>
    <dbReference type="GeneID" id="57024316"/>
    <dbReference type="GeneID" id="66448592"/>
    <dbReference type="KEGG" id="lpl:lp_0541"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.448"/>
    <dbReference type="eggNOG" id="COG1188">
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    <dbReference type="OMA" id="VANEACD"/>
    <dbReference type="PhylomeDB" id="F9UL15"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-451-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="10875" checksum="2E9BB1888DD230A1" modified="2011-10-19" version="1">MSMRLDKFLKVSRIIKRRSVAKEIADKGRIQINGKVAKSSSNVSVDDELIISFGNKTLTVKVTQLLETTKKNDAELMYDIISEDYKTDYRQPFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULE4</accession>
    <name>F9ULE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642937.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3590"/>
    <dbReference type="EnsemblBacteria" id="CCC80551">
        <property type="protein sequence ID" value="CCC80551"/>
        <property type="gene ID" value="lp_3590"/>
    </dbReference>
    <dbReference type="GeneID" id="57026784"/>
    <dbReference type="KEGG" id="lpl:lp_3590"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2995"/>
    <dbReference type="eggNOG" id="COG5506">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111531_0_1_9"/>
    <dbReference type="OMA" id="QYPFTIM"/>
    <dbReference type="PhylomeDB" id="F9ULE4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3038-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012543">
        <property type="entry name" value="DUF1694"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07997">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034303">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="15636" checksum="66A6584914EA88DD" modified="2011-10-19" version="1">MQGKRPDLDQRIQNAVFGLPLVRPDEQHRCLGTFYERIELRISFAEALKYNCSGVLQRLLKENSKYQLLINGQLDMDIMGQYIQSAKQNGVLFAIRNSQYYRADSNSAAVILCADHALNRDTVDVLERYPQLNKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK3</accession>
    <name>F9ULK3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorbitol operon transcription antiterminator,BglG family</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srlR2</name>
        <name evidence="5" type="ordered locus">lp_3656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.140" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102281.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891124.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3656"/>
    <dbReference type="EnsemblBacteria" id="CCC80610">
        <property type="protein sequence ID" value="CCC80610"/>
        <property type="gene ID" value="lp_3656"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3656"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3054"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_5_3_9"/>
    <dbReference type="OMA" id="AFPHTIN"/>
    <dbReference type="PhylomeDB" id="F9ULK3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3097-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="274"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="3">
        <location>
            <begin position="473"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="621" mass="71704" checksum="3ECDC5689DE96261" modified="2011-10-19" version="1">MDRQSFEILNFFINNDALTLRELQSHFSVSRVTITKNIRAINDYLVGIAKINVNQAKFYLVINNYSAMAKLQTNFLKKDLDFNDPLKRQATILKELLQQITDYVILDDLAESLAVSRGTINKDLKALKQQLDYYQVRIETKTNRGIHLAVEHDYMYAVITRTLVGKYYELEATWDKATDVKLLNLVKKLDHNNDTVTMVKRNIAVINWLRKYNIQINDRINNYHPLLSDVTMACLRNLVTEIIGSSLSTSEWEFISYPLNIRKLPKDDNQLVQVGLVEVEDLMQSVFPILKQKLDVNLDFKRLLMELRYHLLFLINRAIFDVKSEGFISVDMLSKYPVSTELAQLTLSTIATKLNIRIRSQEVGYLTVYFQMELEEYMAAPIIHRVALVEPINTSMKKFISEKLKEMLDDDLQIDVFNSISEWEQSPEKYLLIFSNSFLTDNELINHAPIIRLNSIFNQGTLRERLQISLVDEAVNQGQCRFDVTQFDEQETYVTGVKKLINQEIQHGQLTPDFMQAWLNREQQSSSIFGDGVALPHVIDKSGLNRILVTVGVFEKPVVFDNQKVNVVFLVAIPYKLDATLSKILAQVYDLIRSITANSNIYNNLKNYDENQGLNQLMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL2</accession>
    <name>F9ULL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenolic acid decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">padA</name>
        <name evidence="1" type="ordered locus">lp_3665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2006-03" db="PDB data bank">
            <title>Crystal structure of p-coumaric acid decarboxylase (NP_786857.1) from Lactobacillus plantarum at 1.70 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="journal article" date="2010" name="Proteins" volume="78" first="1662" last="1676">
            <title>p-Coumaric acid decarboxylase from Lactobacillus plantarum: structural insights into the active site and decarboxylation catalytic mechanism.</title>
            <authorList>
                <person name="Rodriguez H."/>
                <person name="Angulo I."/>
                <person name="de Las Rivas B."/>
                <person name="Campillo N."/>
                <person name="Paez J.A."/>
                <person name="Munoz R."/>
                <person name="Mancheno J.M."/>
            </authorList>
            <dbReference type="PubMed" id="20112419"/>
            <dbReference type="DOI" id="10.1002/prot.22684"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS)</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="5">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641609.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2GC9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=1-178"/>
    </dbReference>
    <dbReference type="PDB" id="2W2A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.38 A"/>
        <property type="chains" value="A/B=1-178"/>
    </dbReference>
    <dbReference type="PDB" id="2W2B">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A/B=1-178"/>
    </dbReference>
    <dbReference type="PDB" id="2W2F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.73 A"/>
        <property type="chains" value="A/B/C/D=1-178"/>
    </dbReference>
    <dbReference type="PDB" id="2WSJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.24 A"/>
        <property type="chains" value="A/B=1-178"/>
    </dbReference>
    <dbReference type="PDBsum" id="2GC9"/>
    <dbReference type="PDBsum" id="2W2A"/>
    <dbReference type="PDBsum" id="2W2B"/>
    <dbReference type="PDBsum" id="2W2F"/>
    <dbReference type="PDBsum" id="2WSJ"/>
    <dbReference type="SMR" id="F9ULL2"/>
    <dbReference type="STRING" id="220668.lp_3665"/>
    <dbReference type="DNASU" id="1061602"/>
    <dbReference type="EnsemblBacteria" id="CCC80619">
        <property type="protein sequence ID" value="CCC80619"/>
        <property type="gene ID" value="lp_3665"/>
    </dbReference>
    <dbReference type="GeneID" id="57026845"/>
    <dbReference type="KEGG" id="lpl:lp_3665"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3063"/>
    <dbReference type="eggNOG" id="COG3479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129251_0_0_9"/>
    <dbReference type="OMA" id="VCFQNDH"/>
    <dbReference type="PhylomeDB" id="F9ULL2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3106-MON"/>
    <dbReference type="SABIO-RK" id="F9ULL2"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14241">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PTHR40087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011561">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2GC9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2W2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2W2B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2W2F"/>
        </source>
    </evidence>
    <sequence length="178" mass="21010" checksum="C8ED70783E6F7496" modified="2011-10-19" version="1">MTKTFKTLDDFLGTHFIYTYDNGWEYEWYAKNDHTVDYRIHGGMVAGRWVTDQKADIVMLTEGIYKISWTEPTGTDVALDFMPNEKKLHGTIFFPKWVEEHPEITVTYQNEHIDLMEQSREKYATYPKLVVPEFANITYMGDAGQNNEDVISEAPYKEMPNDIRNGKYFDQNYHRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULU7</accession>
    <name>F9ULU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonates ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnE1</name>
        <name evidence="7" type="ordered locus">lp_0712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888700.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0712"/>
    <dbReference type="EnsemblBacteria" id="CCC78186">
        <property type="protein sequence ID" value="CCC78186"/>
        <property type="gene ID" value="lp_0712"/>
    </dbReference>
    <dbReference type="GeneID" id="57024421"/>
    <dbReference type="KEGG" id="lpl:lp_0712"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.599"/>
    <dbReference type="eggNOG" id="COG3639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064254_1_2_9"/>
    <dbReference type="OMA" id="MVWFRRR"/>
    <dbReference type="PhylomeDB" id="F9ULU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-621-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30043:SF1">
        <property type="entry name" value="PTHR30043:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="30641" checksum="DDF86783A5B816C2" modified="2011-10-19" version="1">MIENSQPKTQVLQPSAPPTRSISLVTRPRKILRAVMIGLTLISVYSLVTLNNANLNIIDALHSLGLNLNAMFLHPSVGQDTLGQLLRALMTSVSLAMLTTLLGALIAFFIAVGAARNLAPSWLATSIKAVMAFIRAIPTILWVLIYSVVMGLGASAAVVGLTFHSVAYLVKAYSESIEETSQDTIEALKASGVGFWPIVFQAILPSIIPALLSWTFIRFEINFANAVAVGAAAGADDIGYYLFMAGSFYFDFHEVGLIVYLLLGVAIVLELVSMRLRGHYLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM41</accession>
    <name>F9UM41_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase/phosphodiesterase, EAL domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101167.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888794.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0823"/>
    <dbReference type="EnsemblBacteria" id="CCC78280">
        <property type="protein sequence ID" value="CCC78280"/>
        <property type="gene ID" value="lp_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0823"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.698"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089605_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UM41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-716-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="223" mass="25455" checksum="DFBD97FC87040791" modified="2011-10-19" version="1">MVMLKYKYFAQPINNLGTNRTILYELLLRQWDERQQTWRIPATFEIAPTELIQLLDCAIQELNNHHVSINLTARQFANPDFQAAISHYVQTHLLPRELTVELVATPELSELQQLSVGYRAAGILLAFDDVGSDNLFQQIKMMLPYVNTVKFALQNMRPLGTPTTDAIVSTLKFWFDKAEEQQMLFTFEGIESAADVQLANHLGITRGQGYYFAKPQLPATFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM52</accession>
    <name>F9UM52_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase (RNAP)-binding regulatory protein, arsenate reductase (ArsC) family, Spx subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spx1</name>
        <name evidence="4" type="ordered locus">lp_0836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888805.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0836"/>
    <dbReference type="EnsemblBacteria" id="CCC78291">
        <property type="protein sequence ID" value="CCC78291"/>
        <property type="gene ID" value="lp_0836"/>
    </dbReference>
    <dbReference type="GeneID" id="57024533"/>
    <dbReference type="GeneID" id="66448794"/>
    <dbReference type="KEGG" id="lpl:lp_0836"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.711"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_9"/>
    <dbReference type="OMA" id="HQIDYIE"/>
    <dbReference type="PhylomeDB" id="F9UM52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-727-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="16311" checksum="B70347D7E16E19E8" modified="2011-10-19" version="1">MTVNLYYSTSSKSSRSARAWLVENNIPFNERDIIANPLDRDELKQILRLTENGFEDIVSTRSKAFKALHIDLSDLGFNQLLDLLVEKPQLLKRPIIYDGRRLQIGYNEEDIRAFLPRSVRKSELREIQQKLYDDDQQAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA9</accession>
    <name>F9UMA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbg2</name>
        <name evidence="6" type="ordered locus">lp_0906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888862.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0906"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78348">
        <property type="protein sequence ID" value="CCC78348"/>
        <property type="gene ID" value="lp_0906"/>
    </dbReference>
    <dbReference type="GeneID" id="57024589"/>
    <dbReference type="KEGG" id="lpl:lp_0906"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.768"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="YPYNSDP"/>
    <dbReference type="PhylomeDB" id="F9UMA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-784-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="500" mass="57886" checksum="9501C3079CD7746E" modified="2011-10-19" version="1">MDVYKTSPNFMWGVATAANQVEGAWNEDGKGMSIADCLRYRPQIDSSDYQAVNQMDSAEIENALNDESTKGWAKRHGVDFYHHYREDIKQLAETGINTYRFSISWARIFPNGDDKCPNQAGLDFYLSLVKELAKYQITPVVTLSHYEMPLNLVLNYDAWYDRRVADFFGRYARTVIDYLHDYVKYWIPINEIDSIIRHPFSSAGLVADRFASHDFKTVIYQAMHHQFVAAAQVVKYCHRHYPQMQVGSMITRTMVYPYNSDPNNVLAATQTMREVYAFSDIQVRGEYPEFLLTKLKKAHITIEFQEGDQEVLRENTADFVAFSYYSSICTASNVEGLRVTKANRTVGVYNRYLPESEWGWQIDPVGLRLSLIDLFDRYQKPLFIVENGLGAVDELSSDLRVHDIYRISYLRQHIRQMLIAIANDGVDLMGYCMWGTTDMISASSNQMSKRYGLIYVDLDDNGDGSYNRYLKDSYFWYQELLSYKNQIPAIFLDENSIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMB7</accession>
    <name>F9UMB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888870.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0917"/>
    <dbReference type="DNASU" id="1061925"/>
    <dbReference type="EnsemblBacteria" id="CCC78356">
        <property type="protein sequence ID" value="CCC78356"/>
        <property type="gene ID" value="lp_0917"/>
    </dbReference>
    <dbReference type="GeneID" id="57024597"/>
    <dbReference type="KEGG" id="lpl:lp_0917"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.776"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_4_0_9"/>
    <dbReference type="OMA" id="KWSLQYT"/>
    <dbReference type="PhylomeDB" id="F9UMB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-792-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="14175" checksum="0C3DB13277C06F40" modified="2011-10-19" version="1">MPAKTQNNFIRRLINLRDSRNWSKTEVARKLGLSSMQRYANYEYGTNEPDLNMLKQIADLYDVTTDYLLGEDSASKWIARKDTTDLKDFLTAHVDSMTYGGEALTEEERQQVRVAMAVIFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMP9</accession>
    <name>F9UMP9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tkt2</name>
        <name evidence="10" type="ordered locus">lp_1083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1083"/>
    <dbReference type="EnsemblBacteria" id="CCC78488">
        <property type="protein sequence ID" value="CCC78488"/>
        <property type="gene ID" value="lp_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1083"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.917"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_9"/>
    <dbReference type="OMA" id="APMMWAL"/>
    <dbReference type="PhylomeDB" id="F9UMP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-931-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="670" mass="72114" checksum="687231E19D744EDA" modified="2011-10-19" version="1">MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWANRDRFVLSAGHGSALLYSLLHVSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPLGQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGDLMEGVSHEAASFAGNQQLQKLIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRPSLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLILQRGQRAHRRWQSQREALPQAVQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQKLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNVAFGVREFGMGTILNGMTLHGGLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLIPNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLSPQRGRQPMGILIASGSEVALALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPPQIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQVLAANQFTVADLVRTYQQTHVDLGQQLRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ0</accession>
    <name>F9UMQ0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroD1</name>
        <name evidence="4" type="synonym">aroE</name>
        <name evidence="7" type="ordered locus">lp_1084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1084"/>
    <dbReference type="EnsemblBacteria" id="CCC78489">
        <property type="protein sequence ID" value="CCC78489"/>
        <property type="gene ID" value="lp_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1084"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.918"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_4_9"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="PhylomeDB" id="F9UMQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-932-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="32221" checksum="688974C0BABEB96E" modified="2011-10-19" version="1">MIDGQTALFGFIAHPARHSRSPRMHNLSFDYWGLNARYLAFDVAPDGLAGTLAGIRSMGIAGVNLSMPFKQTVVPLLDGLTVRAQRIQAVNTIKNEAGKLIGDSTDGAGVFQDLLHQGLNLVDKHVMVLGAGGAGKAIIAAALDYGVASVTVFKRNNERYAGVQHWLEQLSTTTSVPLRLCAYEDQVRMQQVARTSNLIINATNIGMTTAGTPLPISIIQQLVPQQTVYDVIYQPLETTFLRLARQQGCATYNGLGMLIWQGALAFEFWTGKQMPVQQVRQDMLASIQATPPITAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ1</accession>
    <name>F9UMQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroA</name>
        <name evidence="2" type="ordered locus">lp_1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1085"/>
    <dbReference type="EnsemblBacteria" id="CCC78490">
        <property type="protein sequence ID" value="CCC78490"/>
        <property type="gene ID" value="lp_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="57024736"/>
    <dbReference type="KEGG" id="lpl:lp_1085"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.919"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_9"/>
    <dbReference type="OMA" id="IVMRPDA"/>
    <dbReference type="PhylomeDB" id="F9UMQ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-933-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="331" mass="35557" checksum="8483C43489DFDD83" modified="2011-10-19" version="1">MIIILKPATATAMQAKLVSQFGADHEIFTHNNRIAIQGLRPEALPADVQAASESILTAVPAAVQSSRLFHPEDTIIKTPHSVIGGNQFVMMAGPCSVESAEHVDQMAAVAKQGGATIVRGGAFKPRTSPYSFQGLGETGLQYLRTAADKHGLDMITEVMDDEHVAMVAKYTDIFQIGARNMQNFSLLKAVGQTQIPVALKRGMSATIDDVLNAAEYIAAGGNHQIMLLERGIRTFDNKYTRNTFDLGAVPVLQSLTHYPVIVDPSHAVGTWELVTPMAMAGVAAGASGMIVEIHDQPTQALSDGPQALKPATYLKMAQQAFQLHDLMQTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ6</accession>
    <name>F9UMQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L(+)-tartrate dehydratase, subunit A</fullName>
            <ecNumber evidence="8">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttdA</name>
        <name evidence="8" type="ordered locus">lp_1090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1090"/>
    <dbReference type="EnsemblBacteria" id="CCC78495">
        <property type="protein sequence ID" value="CCC78495"/>
        <property type="gene ID" value="lp_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1090"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.924"/>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMQ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-938-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="33659" checksum="3F72AAD5BD7B97C2" modified="2011-10-19" version="1">MDTMTYDYTEPTLSAKGQRMRDILADYIALISHRLPDDVTAKLEELSKIEVDPLQKLVYDTMMENQLLANKLKRPSCQDTGALQFFIKCGAQFPLLGELNQILKDAVYRGTKKAPLRHNAVQTFDEYNTGMNIGDGIPSIFLQVDGNGTDISMYVYMAGGGCTLPGAAKVLMPGEGYEGVVRFVMDRMTSYGINACPPLLVGVGVATSVETAALNSKLALMRRVDSENPNANAAKLEHLLEDGINHIGLGPQGFGGQKSVMGVNVENTARHPSTIGVAVSTGCWSHRRGLINFDADLNYDLPLNKGVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR1</accession>
    <name>F9UMR1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Manganese/zinc ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtsA</name>
        <name evidence="5" type="ordered locus">lp_1097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641296.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889014.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1097"/>
    <dbReference type="EnsemblBacteria" id="CCC78500">
        <property type="protein sequence ID" value="CCC78500"/>
        <property type="gene ID" value="lp_1097"/>
    </dbReference>
    <dbReference type="GeneID" id="66449000"/>
    <dbReference type="KEGG" id="lpl:lp_1097"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.929"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_9"/>
    <dbReference type="OMA" id="DPHIWFD"/>
    <dbReference type="PhylomeDB" id="F9UMR1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-943-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388848" evidence="4">
        <location>
            <begin position="32"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="313" mass="34626" checksum="0F6115E741AA4A73" modified="2011-12-14" version="1">MKTKLIALIGVIAMVTGMAVFLNQRQQSAKATTTSAKIRVVSTNSILDDMVKNVGGQYVQNYSIVKRGTDPHEYEPRPTDIAATAEADVIFYNGLNLETGGNGWFKKLVTASKKDFDHDVFAASKGIKVKYLTTNVNEPDPHAWLDLANGIQYVKNINRTLQAKDPKHAAVYQKNTDRYVAKLTKLHESAQTKFKQIPTSQRLLVTSEGAFKYFSAAYHVPAAYIWEVNTESQGTPAQMRTALKKIEGTQVRSLFVESSVSPKSMNKLSQETGIPVASTIFTDSLAAKGKPGDTYYSMLKWNLDKIYAGLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR9</accession>
    <name>F9UMR9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate lyase subunit beta</fullName>
            <ecNumber evidence="8">4.1.3.34</ecNumber>
            <ecNumber evidence="9">4.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Citrate (pro-3S)-lyase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Citryl-CoA lyase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">citE</name>
        <name evidence="19" type="ordered locus">lp_1108</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Represents a citryl-ACP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(3S)-citryl-CoA = acetyl-CoA + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:20812"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57321"/>
            <dbReference type="EC" id="4.1.3.34"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>citrate = acetate + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:10760"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="4.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer with a subunit composition of (alpha,beta,gamma)6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.34" evidence="8"/>
    <dbReference type="EC" id="4.1.3.6" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1108"/>
    <dbReference type="EnsemblBacteria" id="CCC78508">
        <property type="protein sequence ID" value="CCC78508"/>
        <property type="gene ID" value="lp_1108"/>
    </dbReference>
    <dbReference type="GeneID" id="57024754"/>
    <dbReference type="KEGG" id="lpl:lp_1108"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.937"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044864_0_0_9"/>
    <dbReference type="OMA" id="AWLFCPA"/>
    <dbReference type="PhylomeDB" id="F9UMR9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-951-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009346">
        <property type="term" value="C:ATP-independent citrate lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008816">
        <property type="term" value="F:citryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006475">
        <property type="entry name" value="Citrate_lyase_beta_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01588">
        <property type="entry name" value="citE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="18">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00015712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCC78508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="33263" checksum="916FFF839DF7DB0A" modified="2011-10-19" version="1">MAENEERLRRTMMFVPGNNPAMVKDAGIYGADSIMFDLEDAVSMAEKDAARVLVYEALKTQDYGNAELVVRINGLDTKYYADDVKAMVKAGIDVIRLPKVESATMIQTLEKDVAAAEAEFKIPVGTTHLMAAIESAKGVLNAPAIAAASDRMIGIALSAEDYTTDMKTHRYPDGAELEFARNMVLHAARAAGIAAFDTVFTNMADPDGFYRETRHIHQLGFDGKSLVNPRQIAMVNSVYEPTKDEVIKAQKVIAAIEEARIKGSGVISMNGQMVDRPVVLRAQRVMSLAKVSNLLDEEGNYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT5</accession>
    <name>F9UMT5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome D ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ordered locus">lp_1129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1129"/>
    <dbReference type="EnsemblBacteria" id="CCC78524">
        <property type="protein sequence ID" value="CCC78524"/>
        <property type="gene ID" value="lp_1129"/>
    </dbReference>
    <dbReference type="GeneID" id="57024771"/>
    <dbReference type="KEGG" id="lpl:lp_1129"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.954"/>
    <dbReference type="eggNOG" id="COG4987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="VSHNATF"/>
    <dbReference type="PhylomeDB" id="F9UMT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-967-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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        <property type="entry name" value="SSF90123"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="24"/>
            <end position="44"/>
        </location>
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    </feature>
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            <begin position="26"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78524.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="586" mass="66287" checksum="53CDBEAE164086BD" modified="2011-10-19" version="1">MKDFLATFKNDTWVMPYLRKYKKLLALTLFLGLMTFFCGSALMFNSGYLISKAARHPYNILMIYVPIVLTRAFGIGRPAFRYAERITSHNWVLRIVSDFRKKLYQSVAKHAVAIRQNFQTGDVLSILADDIDHIENLYLRTVFPTVIAWLMTLVIVIGLGYFSWWFGLLMLLMLGLVVVIMPLWSVLLNGARESRSRQIQQGFYTQLTDSVMGLGDWLIAGRQTDFYERQTQPIEAIAALRKQDHRFQWWRDFTIQIIFGVICLALLIWSSFYWTTNAASSNWIAAFVLSVFPLVDAMQSVSQGVSEWPSYQRSIKRVNALDTTPEDEHDQTVLTEPFQVLRIADLDFKYAEGGHAIFDGLNLTLKAGEKLALLGPSGTGKSTLLKLILGDLTPDSGTVQLNDVPITRLQNERAQLFGVLDQQPYLFNTTIMNNVRMGNLQATDEQVKAALAAVELAPLIDTLPDGYETVVEEGGARFSGGERQRLALARILLQDAPIIILDEPTVSLDPITEAHLLTTVFRVLHDKTILWVTHHLAGVNHVDQVRFLEDGQFDMAGTPSELYANAPRFKRLYDLDQGRDDANNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCC78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="335" mass="37109" checksum="3E1A13CF2861277C" modified="2011-10-19" version="1">MLKLGIIGTNWITQQFIDAAAASGEWQLTSVYSRHAETAQAFAAKNHADETFTDLDAFFSRGSFDTVYIASPNSLHFAQAKQAIAYGKHVIVEKPAVANQQEFEQLDAVLKAHPDVLLFEAARQIHEVNFQRVKDQIKKLSLVQGATLTYMKYSSRYDAVLAGEEPNIFSLNFAGGALQDLGVYLAYDAVGWFGMPEEVAYYPTLIRTGVDGKGVAILRYADFTVTLNVGKTSDSFLPSEINGLRDAIVMDNPAELGQITYQDKDGQEHAIGAQPDTNPMLAEARDFATVINDPSNHQTEYLAWRQLSRNVNKLLFNLRQSGHLYFTGEAPDTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF7</accession>
    <name>F9UNF7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface protein, ErfK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1403"/>
    <dbReference type="EnsemblBacteria" id="CCC78746">
        <property type="protein sequence ID" value="CCC78746"/>
        <property type="gene ID" value="lp_1403"/>
    </dbReference>
    <dbReference type="GeneID" id="57025038"/>
    <dbReference type="KEGG" id="lpl:lp_1403"/>
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    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="PhylomeDB" id="F9UNF7"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LD_TPept_cat_dom"/>
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        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
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        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="203" mass="22843" checksum="A7F11B196E6A3339" modified="2011-10-19" version="1">MKISVHQLIWVTIGAISLTIFTGFGHLFARHHQAIASNRPITKVSHSATKVTTPVPETVDWHKPSLSRPYPKLAKYDDINIQVSIKKQRVYLKNHDQTLYTMLASTGKHGSDTPKGHFEIQAERGQHFFNTQSGEGANYWVSFKDHGIYLFHSVPVDANDQYIVKEAQQLGKVANSHGCIRLTIADAKWLYENISTHTPVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG3</accession>
    <name>F9UNG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1412"/>
    <dbReference type="EnsemblBacteria" id="CCC78752">
        <property type="protein sequence ID" value="CCC78752"/>
        <property type="gene ID" value="lp_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1412"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1184"/>
    <dbReference type="eggNOG" id="ENOG5030APT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_216854_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1213-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="40" mass="4964" checksum="53F2A225D136C523" modified="2011-10-19" version="1">MKYTKKRAPRKNQKQRDATFDKFKQQQNELNANRRGVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI6</accession>
    <name>F9UNI6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640242.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1443"/>
    <dbReference type="EnsemblBacteria" id="CCC78775">
        <property type="protein sequence ID" value="CCC78775"/>
        <property type="gene ID" value="lp_1443"/>
    </dbReference>
    <dbReference type="GeneID" id="57025076"/>
    <dbReference type="KEGG" id="lpl:lp_1443"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1208"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_3_9"/>
    <dbReference type="OMA" id="HELLMTM"/>
    <dbReference type="PhylomeDB" id="F9UNI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1236-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="208" mass="23863" checksum="1E5DE32D30D91EAA" modified="2011-10-19" version="1">MTQLNQRRRGNRLENAIYDTTYTLLSQYGLDQVTFSRVATAAATSRSVLYRYWDSTFDLIFHTIIHQIQKTPIALTTTPLDTGSLRTDLILLAQRFIQQTSTGPFRYFRLLFATALNAQNQRDLTQLVTQIDHANLTLIEPLLTNAQNHGELQIWPNQAAQLVLFQQLRYCDIINQPMNTDQQLTNLIDQVVLPALRASGVANRHFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK8</accession>
    <name>F9UNK8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, ATP-binding protein,iron-sulfur cluster assembly ATPase protein SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sufC</name>
        <name evidence="7" type="ordered locus">lp_1468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889311.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1468"/>
    <dbReference type="EnsemblBacteria" id="CCC78797">
        <property type="protein sequence ID" value="CCC78797"/>
        <property type="gene ID" value="lp_1468"/>
    </dbReference>
    <dbReference type="GeneID" id="57025097"/>
    <dbReference type="GeneID" id="66449357"/>
    <dbReference type="KEGG" id="lpl:lp_1468"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1230"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_9"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="PhylomeDB" id="F9UNK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1258-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="265" mass="29267" checksum="7D2A8D51EB6EBF41" modified="2011-10-19" version="1">MATLEVKDLHVEVTDDEQKKSREILKGVNLSMKTGEIHAIMGPNGTGKSTLSQTIMGQPAYHVTQGDILLNGESIVNMPVDERARKGLFLGMQYPAEIQGVTNAEFLRAAMNARRPADDQISVMAFLKELDKNLALLNMSESMTERYLNEGFSGGEKKRNEILQLLMIKPSFALLDEIDSGLDIDALQVVSKGVNSMRGDNFGSLIITHYQRLLNYIVPDVVHVMMGGRIVKTGNADLAKTLEKEGYAGLRDDLNIDVKLVDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNT6</accession>
    <name>F9UNT6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent phosphohydrolase, HD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640309.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889389.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1556"/>
    <dbReference type="DNASU" id="1061928"/>
    <dbReference type="EnsemblBacteria" id="CCC78875">
        <property type="protein sequence ID" value="CCC78875"/>
        <property type="gene ID" value="lp_1556"/>
    </dbReference>
    <dbReference type="GeneID" id="57025145"/>
    <dbReference type="GeneID" id="66449443"/>
    <dbReference type="KEGG" id="lpl:lp_1556"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1309"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104072_1_0_9"/>
    <dbReference type="OMA" id="TFVDKYC"/>
    <dbReference type="PhylomeDB" id="F9UNT6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1336-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="19493" checksum="988F60D1D878D2D1" modified="2011-10-19" version="1">MKTNNAWQQDSEYVAIVEDLLAQPAVQRLAEFTQHHHSNRLDHSIAVSYDSYVLAKKWHLNTTAVARGGLLHDLFYYDWRETKFDLGSHAFIHPRVALRNAEKLTKLTPMEKDIILKHMFGATLAVPKYRESLLVSLVDDYEAEHEFFGPLRMKVAKQLDRFRGKVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP18</accession>
    <name>F9UP18_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase, component I</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpE</name>
        <name evidence="3" type="ordered locus">lp_1652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101488.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889471.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1652"/>
    <dbReference type="EnsemblBacteria" id="CCC78957">
        <property type="protein sequence ID" value="CCC78957"/>
        <property type="gene ID" value="lp_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1652"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1393"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_9"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="PhylomeDB" id="F9UP18"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1420-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="205"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="478" mass="53063" checksum="FC66B10E3238EA3C" modified="2011-10-19" version="1">MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSFKPQRSLTGRQLAKHKRPANETLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKLHLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTADLAATYAVTQTALTQQLAAIIEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGSLLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAEDQQLAHELQTSPKEIAEHNMLVDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAAEVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVPRGAYGGCFGYLDCNGNLDMAIGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP19</accession>
    <name>F9UP19_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase, component II</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpG</name>
        <name evidence="2" type="ordered locus">lp_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640393.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889472.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1653"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="EnsemblBacteria" id="CCC78958">
        <property type="protein sequence ID" value="CCC78958"/>
        <property type="gene ID" value="lp_1653"/>
    </dbReference>
    <dbReference type="GeneID" id="57025229"/>
    <dbReference type="KEGG" id="lpl:lp_1653"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1394"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_3_9"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="PhylomeDB" id="F9UP19"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1421-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="191" mass="20798" checksum="21F6CC4F07D6B702" modified="2011-10-19" version="1">MELLIDNYDSFTYNLYQLIGRLTPDVRVIKNDDLTVAAIKALQPDHIILSPGPGTPAHTGVSPQVVQQLAGQVPILGICMGLEVMVTAFGGSLQGAQHLVHGQATLMHVQPSSLFKDCPMQFMAARYHSLVADAGRLPVNFRIIGTSDDQEIMAVEDVGRQLYGVQFHPESIMTPAAVGEQLIRNFLALKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP30</accession>
    <name>F9UP30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase, zinc-binding</fullName>
            <ecNumber evidence="5">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adh1</name>
        <name evidence="5" type="ordered locus">lp_1665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101497.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889483.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1665"/>
    <dbReference type="EnsemblBacteria" id="CCC78969">
        <property type="protein sequence ID" value="CCC78969"/>
        <property type="gene ID" value="lp_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1665"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1405"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_9"/>
    <dbReference type="OMA" id="CCRNFGT"/>
    <dbReference type="PhylomeDB" id="F9UP30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1432-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="4"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="347" mass="36710" checksum="5636F9ADC73D5468" modified="2011-10-19" version="1">MKSTIFEKAGLVSVQEVDKPTLQSDDDVIVRIVRTCVCGSDLWSYAHGDDKAAHSINEGHEAIGIVEAIGSAITTVKPGDFVITPFTHGCGECAACLAGFDGTCDRHPGHTNWSNGFQAEYIRFTYGNWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHAARCANVQKGDKVVVIGDGAVGQCAVIAAKLRGAAQIVLMSRHEDRQQMALASGATAVVAERGDEGIAKVREILGGGADAALECVGTEAAIDQALGVLHNGGRVGYVGVPHYNNRPLGSTFAQNIAVAGGSASVTTYDKQFLLKAVLDGNINPGRVFTQTYPLADINQAYQDMQNRKTIKAMITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP42</accession>
    <name>F9UP42_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA carboxylase, biotin carboxylase subunit</fullName>
            <ecNumber evidence="9">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">accC2</name>
        <name evidence="9" type="ordered locus">lp_1678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.2" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889495.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1678"/>
    <dbReference type="EnsemblBacteria" id="CCC78981">
        <property type="protein sequence ID" value="CCC78981"/>
        <property type="gene ID" value="lp_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1678"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1417"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_9"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="PhylomeDB" id="F9UP42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1444-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="462" mass="50707" checksum="E24B3C97F621D053" modified="2011-10-19" version="1">MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSYLNMQAIISAANLTGCQAIHPGYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENARQTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAAAGGGGKGIRAVSNDQDLAKAFRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLEESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVTEMVTGIELIKAQVQIAAGIPLKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIYPMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMVSRKMHRCLLELTIDGVQTNRTFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP94</accession>
    <name>F9UP94_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspAT</name>
        <name evidence="4" type="ordered locus">lp_1739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889547.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1739"/>
    <dbReference type="EnsemblBacteria" id="CCC79033">
        <property type="protein sequence ID" value="CCC79033"/>
        <property type="gene ID" value="lp_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1739"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1467"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_9"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="PhylomeDB" id="F9UP94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1496-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="43784" checksum="7F661D0DA6803104" modified="2011-10-19" version="1">MYMELSRKVMQVQPSATLKISATAKQMMADGVDVINLGIGEPDFQTPDNIKQAAIDSIQNGQASFYTPATGLPALKQAISQRIEADHHYHFDPNQIVVTDGAKMALFTLFQVILNPDDEVLLPVPYWVSYSEQVKLAGGVPVEVSTDEQLRFTTADLEAQRTPKTKALVLNSPQNPSGLVFSRAELTAIVNWAVEHDVLVIADEIYEKLLYNGNEFTSVLELDDANMDHVVLINGVSKAYSMTGWRIGYAAGPQTIMAKMGVVLGHAASNPAAVSQYAAIEAFSGDQSSVETMRQGFEARLNELYPLIERLPGFKMPAGKPAGAFYLFPDITEALRLTGYADAPAFVTAVLLEAHVGLVPGEAFGMPGCLRLSYATDIDSLREAHRRLQKFMTEKIAEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC0</accession>
    <name>F9UPC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101544.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1770"/>
    <dbReference type="EnsemblBacteria" id="CCC79059">
        <property type="protein sequence ID" value="CCC79059"/>
        <property type="gene ID" value="lp_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1770"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1493"/>
    <dbReference type="eggNOG" id="ENOG5032JPE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114697_0_0_9"/>
    <dbReference type="OMA" id="FNLWITT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1522-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="27605" checksum="49716E1593EBB831" modified="2011-10-19" version="1">MHKYSVQVGVYTQYFFKVIRDTPGVLIYTICLPLVFLIMNVSSAFFKPLSLTTYTAQVVPYIGWMIFSNCLTTASNVAILREQGYLKQYRTLVVSPAVFLVSQALVSLGIILMTLLLVALLSAITFKLAFLSLLGRLWLTVLLTYLPVTCFGLPLIALALRRKTVDMIGNALALIVVVGTFMLSNMLAVSANNPLLNLVSPIYLVTNVFAMISVGHVSHFMTTYLLSLIVLLVIGGFSYRHIKILPTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC4</accession>
    <name>F9UPC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD-dependent</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644384.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1776"/>
    <dbReference type="EnsemblBacteria" id="CCC79063">
        <property type="protein sequence ID" value="CCC79063"/>
        <property type="gene ID" value="lp_1776"/>
    </dbReference>
    <dbReference type="GeneID" id="57025389"/>
    <dbReference type="KEGG" id="lpl:lp_1776"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1497"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_9"/>
    <dbReference type="OMA" id="YPQDAQV"/>
    <dbReference type="PhylomeDB" id="F9UPC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1526-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="368" mass="40389" checksum="EEEA9FF46BCB5D6F" modified="2011-10-19" version="1">MQKQVTIIGSGIVGAVTAYYLSQNPDLNVTIYDEGIGQATKNSAGIISPWLSKRRNQRWYQLAKAGAALYPEIVADTQMGYSVYQQAGTIVTRADPDDLQALYDLALKRRQAAPQMGTIEKLTAEEVQERIPLLTAPQPGVFVSGGARVDGDKFAHNLLKYAEKRNLVRHKGKVRLGDQGQLLTVNGQQSYDTLILAVGAWLKPLLLPMKIVADVRPQKGQLIEMQLPETWADDVPVLMPEGERDFIPFTRSKLVVGATHENDQGYDLQVSSLVEDDLFASGLKLDANLTKDQITQVKVGTRAYTRDFAPFFGPIPDNPHILVASGLGSSGLTTGPMIGKLLADYVQTGAHDWDQYQRPIETYLAPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH0</accession>
    <name>F9UPH0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YozE_SAM_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889623.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79109">
        <property type="protein sequence ID" value="CCC79109"/>
        <property type="gene ID" value="lp_1834"/>
    </dbReference>
    <dbReference type="GeneID" id="57025443"/>
    <dbReference type="GeneID" id="66449670"/>
    <dbReference type="KEGG" id="lpl:lp_1834"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1546"/>
    <dbReference type="eggNOG" id="ENOG5030ADA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825638_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1572-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023089">
        <property type="entry name" value="YozE_SAM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036806">
        <property type="entry name" value="YozE_SAM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06855">
        <property type="entry name" value="YozE_SAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140652">
        <property type="entry name" value="SSF140652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YozE_SAM_like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7665" checksum="AEF64A3C0ACF1964" modified="2011-10-19" version="1">MTFYRWLEPFIEQNGPFAPAACYAHSDFDFPLTSNVHELSDYITYLNIRDSVKKSFYSALDAYQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH1</accession>
    <name>F9UPH1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="synonym">msrA2</name>
        <name evidence="6" type="ordered locus">lp_1835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640552.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889624.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1835"/>
    <dbReference type="EnsemblBacteria" id="CCC79110">
        <property type="protein sequence ID" value="CCC79110"/>
        <property type="gene ID" value="lp_1835"/>
    </dbReference>
    <dbReference type="GeneID" id="57025442"/>
    <dbReference type="KEGG" id="lpl:lp_1835"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1547"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_1_9"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="PhylomeDB" id="F9UPH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1573-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19245" checksum="EF4F8DBB6F4D9A87" modified="2011-10-19" version="1">MTETAIFAGGCFWCMVKPFDQQPGIKSVISGYTGGTVANPTYEQVASHTTGHTEAVKITFDPDVISYADLVEIYWRQTDPTDASGQFQDRGDSYRPVIFVNSEAQRRTATASRDALAASGKFAEPIVTTIEDAKPFYPAEAEHQDFYRRNPFRYQIEEMGGREAFIKQHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH4</accession>
    <name>F9UPH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644418.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889627.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1838"/>
    <dbReference type="EnsemblBacteria" id="CCC79113">
        <property type="protein sequence ID" value="CCC79113"/>
        <property type="gene ID" value="lp_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1838"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1550"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="FHISYVY"/>
    <dbReference type="PhylomeDB" id="F9UPH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1576-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="36844" checksum="7CB48648DF531D18" modified="2011-10-19" version="1">MKTTQESIFSSKTLTYFLQLAETMNYTQAAQILGITQPALTQQIKKLERTVGAPLFYSVGKKLRLSDAGYTMLNATHSIYSVLNKATDEIQQTTSATQGTINIGVLASIEDHVFEDFAIKYYEANPNVIISLHMLTRKEIWERLENNRIDLAVMYLPDESIKNWKPYQSKKIIQDELLFISGDEKLAKKKRIKFKDTTLNPWVTYPENYYLDQVVKESYKNQLADLPTAVARFTTPQQIYRFVAATNTNTALPNSFMVANPATDKLHTLSFEPAIKFDLNFVFRKDKDQIPRIKNFLDEFDAYLRTEDYISRLQKINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ23</accession>
    <name>F9UQ23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101646.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889826.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2069"/>
    <dbReference type="EnsemblBacteria" id="CCC79312">
        <property type="protein sequence ID" value="CCC79312"/>
        <property type="gene ID" value="lp_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2069"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1754"/>
    <dbReference type="eggNOG" id="ENOG50305J0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1935372_0_0_9"/>
    <dbReference type="OMA" id="CTWQVRV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1772-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="14275" checksum="6BA5C0F9E9645ADE" modified="2011-10-19" version="1">MWFSHHQKRNSLQAPVAGTYTVIPTATSPQQIGLLAIQPTSPVINAPIDGDIISLSPSRLVINSLSNQHIELRIDRTNFHNNCTWQVRVGDSVSPLTIVGTLYGSLKDVTIAVYRIDTIQATNWVSLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ28</accession>
    <name>F9UQ28_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/sulfonate/bicarbonate ABC transporter,permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644507.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889831.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2077"/>
    <dbReference type="EnsemblBacteria" id="CCC79317">
        <property type="protein sequence ID" value="CCC79317"/>
        <property type="gene ID" value="lp_2077"/>
    </dbReference>
    <dbReference type="GeneID" id="57025623"/>
    <dbReference type="KEGG" id="lpl:lp_2077"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1759"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_9"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="PhylomeDB" id="F9UQ28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1777-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="378"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="580" mass="65454" checksum="A03BD1B97E50A6B2" modified="2011-10-19" version="1">MTSLKRGIKVRSVVGTMMWLGLSIGILLMIGWCIAKMNLPLSRLPTQGYLDTTGGKDYLTMSHLVAAALRTTTRLFIGMGYSILFSLIFGILAARYRSARYVILPIVNLLESVPLLGFLTFTTAWFMGLFPNNVLGVEAVAIFGVFTAQAWNIMLALYQSLRVTPEDLMTVAKQFGCNSWQRFWRLEFLYATPSILWNIVISQSAAWFALVACEQATIVVPKNETLVLPGIGSYIQIALDTANFGAVINAVIALVICVLLVNVFIFQPLIKGTAHYKYGTSTDSQLPQQSQVYDLMVMAKVPLLVKRLHRHIRYWWLYGAPKQWQKLGFSRIIRILKKYTVYWRIAWWLVIAVGLYRLGVLLIKYLDWINLSVLFKWTFLTTSRVLIAVLLSALIFIPLAVWVASNARRLKLIQPVGQVLGSIPADIYIPIVALMITLTGTTQHWWVIPLIMTGTQWYFFFNIIAGYLAIPSDIKDVVNIFHLSGWRWWTHFLIPSLFPSFITAIINAAGAAWNADIAAELISWGTHQYAVTGLGAYIAQNINNKPAEATGVLIICVIVGLCVVLIWQPLYRFAERRFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH2</accession>
    <name>F9UQH2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rbsK2</name>
        <name evidence="10" type="synonym">rbsK</name>
        <name evidence="13" type="ordered locus">lp_2251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2251"/>
    <dbReference type="EnsemblBacteria" id="CCC79461">
        <property type="protein sequence ID" value="CCC79461"/>
        <property type="gene ID" value="lp_2251"/>
    </dbReference>
    <dbReference type="GeneID" id="57025798"/>
    <dbReference type="KEGG" id="lpl:lp_2251"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1904"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_9"/>
    <dbReference type="OMA" id="AMDSIPF"/>
    <dbReference type="PhylomeDB" id="F9UQH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1946-MON"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="31769" checksum="439D9E8C20C0289D" modified="2011-10-19" version="1">MNKVTVLGSLNVDSILRFKRFPKPGETLPLTGKSVAGGGKGANQAIAAARAGAQTTFIGKVGTDQEGAFMVQQLTNSGVNDQYVQHSNVASTGSAFILLDSSSENRILIDGGTNQQVTAEDVERAQPAISASTFLIAQFETPIAATIRGFELAQAAGQKTILNPAPATTTVPAELLATTDLIVPNETETETLTGVHITDEQSMIQGAQKLQALGVANVIITVGSKGAFWMRGAEHGFVPAYKVEAVDTTAAGDTFIGALSSVLMPDFSNLAAAVRFANRASSIAVQKLGAQPSIPTKEAIEAAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL8</accession>
    <name>F9UQL8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">thrA2</name>
        <name evidence="15" type="ordered locus">lp_2308</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2308"/>
    <dbReference type="DNASU" id="1062318"/>
    <dbReference type="EnsemblBacteria" id="CCC79507">
        <property type="protein sequence ID" value="CCC79507"/>
        <property type="gene ID" value="lp_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2308"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1952"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_2_9"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="PhylomeDB" id="F9UQL8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1991-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04245">
        <property type="entry name" value="AAK_AKiii-YclM-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035804">
        <property type="entry name" value="AKIII_YclM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="49851" checksum="A8368EF32408CBCF" modified="2011-10-19" version="1">MKVIKFGGSSLASSQQLQKVLAIVEADQKRKYVIVSAPGKRFDGDTKVTDLLIQYARQTIHHQDTQAVTAAIIDRYAEIGHGFNVPEAQLTPIFETIRNLPKQSYADNTYLMAAFKAHGERLNAQLVAAVFQQSGLNARYLDPKDAGMVVTDVPDDAQIIKSSYDQLAKWANSEQILVIPGFFAYNRNGQICTFSRGGSDITGAIIARGVHAERYENFTDVDAIYAVNPSLVAKPAAISEMTFTEMRELSYAGFSVFHDEALIPAIEDNITVNVKNTNHPEAPGTLIQSTREPNPHYPVTGIASSSSFCSLYLRKYLLNKEVGLGRKILTILENHHISYEHMPSGIDDLTIIFDEHQLTPELEKTLVAEISTAINPDEIYFTHDYSILMLVGENMRNRVGIMSRAATALANDNIKLIMVNQGASEISIMFGVHDNDADQAVIALYKEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM1</accession>
    <name>F9UQM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamine/histidine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnP2</name>
        <name evidence="8" type="ordered locus">lp_2314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641492.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890024.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2314"/>
    <dbReference type="EnsemblBacteria" id="CCC79510">
        <property type="protein sequence ID" value="CCC79510"/>
        <property type="gene ID" value="lp_2314"/>
    </dbReference>
    <dbReference type="GeneID" id="57025846"/>
    <dbReference type="KEGG" id="lpl:lp_2314"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1955"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_9"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="PhylomeDB" id="F9UQM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1994-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23972" checksum="1756645DF7F7F35C" modified="2011-10-19" version="1">MQYILEILPSLLSGAVMTLKIFIWTLIGSLPLGLVVGLGLMSNFKPLQWLLHFYVWLMRGTPLLLQLIFVFYGLPLIGIVFPRYYAALFAFILNYAAYFAEIFRGGLQSIDNGQYESARVLRLSYWQTIRKIVIPQVIKIVLPSVGNEVINLVKDSSLVYVIGLGDLLRAGNVATARDVTLVPLVLVGIIYLALTAVTTFVLGRIEKHYSYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004890041.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_2333"/>
    <dbReference type="EnsemblBacteria" id="CCC79527">
        <property type="protein sequence ID" value="CCC79527"/>
        <property type="gene ID" value="lp_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2333"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1972"/>
    <dbReference type="eggNOG" id="COG5506">
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    </dbReference>
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    <dbReference type="OMA" id="SQANIKF"/>
    <dbReference type="PhylomeDB" id="F9UQN8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2011-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07997">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034303">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="154" mass="17211" checksum="ABF41B501CD68B78" modified="2011-10-19" version="1">MAETDKQPVDRIETAMHGTPKLHPDEQRKYLGTFRERVEVAVTVAQIKQANYVDALNQAFTSHPDDQLYINGNLDQELIGPYIKAASQANIKFTIKTDDIYHTADDDYALVFTAASAINQDIIDVAQRYPSQTSSATPQAEKTPGLLDKFKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ7</accession>
    <name>F9UQQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641449.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2357"/>
    <dbReference type="EnsemblBacteria" id="CCC79546">
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        <property type="gene ID" value="lp_2357"/>
    </dbReference>
    <dbReference type="GeneID" id="57025890"/>
    <dbReference type="GeneID" id="66450103"/>
    <dbReference type="KEGG" id="lpl:lp_2357"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1991"/>
    <dbReference type="eggNOG" id="ENOG50302KN">
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    <dbReference type="HOGENOM" id="CLU_194417_2_0_9"/>
    <dbReference type="OMA" id="VNTHDEA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2030-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021351">
        <property type="entry name" value="DUF2969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11184">
        <property type="entry name" value="DUF2969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8325" checksum="8E923953AEC7E23C" modified="2011-10-19" version="1">MARKDKAISVTLNETKVNGQPVTEVLIGKQVIGQVTQVGERFEAEMVSDNQPFAHTKSFDESLQEILSAYHLHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ4</accession>
    <name>F9UQZ4_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Prophage P2a protein 2, integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2455</name>
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    <organism evidence="4 5">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101785.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2455"/>
    <dbReference type="EnsemblBacteria" id="CCC79633">
        <property type="protein sequence ID" value="CCC79633"/>
        <property type="gene ID" value="lp_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2455"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2072"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_6_9"/>
    <dbReference type="OMA" id="ELGRICN"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2123-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="43422" checksum="DFAB303BD82F47E6" modified="2011-10-19" version="1">MSVTKLNNGKWQARVSYKDDDGNYKSVTHLEKRKTDAVEWETKTKNALLEGADLSRSTESLKHYFLDWIRIYKTDGVSRHTHELYMGNWRHIAAYFKDRPMSAIKRPDYQKFLNEFGRSHGIATSHKLHQQVHTAIKDAVADGILKRDFAYKAHVTGRPPKPVEEKYLTLSDYKKLRKYLIKTADYDHMTMLMMLFQLETGTRFEEAAGLTWDNLDLNNGIVHIKQQWDARRQTFRPTKGNGQADGDITIGPAYCRFMRSYRSTQKDYLELHEMKNPKNLVFWSKLGKIVGNGNANEELGRICNRLKINKVTTHAMRHTHASILILNHESLPYVQHRLRHQKLETTVNTYVHLIEEENGVSDKKATELMDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR11</accession>
    <name>F9UR11_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890164.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2477"/>
    <dbReference type="EnsemblBacteria" id="CCC79650">
        <property type="protein sequence ID" value="CCC79650"/>
        <property type="gene ID" value="lp_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2477"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2087"/>
    <dbReference type="HOGENOM" id="CLU_200432_1_0_9"/>
    <dbReference type="OMA" id="QDDANEF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2142-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="62" mass="7398" checksum="096F67490877992A" modified="2011-10-19" version="1">MMNMKNSFPRYMTYKQAMECLNIKSYNTLYKYIKQGLRVVAINGTKRIDQLDADKFMEAHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR59</accession>
    <name>F9UR59_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="3">HAT</shortName>
            <ecNumber evidence="3">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Homoserine transacetylase</fullName>
            <shortName evidence="3">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metA</name>
        <name evidence="3" type="synonym">metAA</name>
        <name evidence="5" type="ordered locus">lp_2537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101819.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2537"/>
    <dbReference type="EnsemblBacteria" id="CCC79698">
        <property type="protein sequence ID" value="CCC79698"/>
        <property type="gene ID" value="lp_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2537"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2134"/>
    <dbReference type="eggNOG" id="COG1897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057851_0_1_9"/>
    <dbReference type="OMA" id="WLWFCYQ"/>
    <dbReference type="PhylomeDB" id="F9UR59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2191-MON"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3 4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="291" mass="32509" checksum="CDFC816338035C44" modified="2011-10-19" version="1">MTVTANNGLLVARGEWANATCQESHQAQQILILNLMPTKVTTERQFLKRFAAGNTDVAVTFMYPASHHFKSLPQAVVAAHYVTLADIQDQYFDGLIVTGAPVETLPFEAVDYWNELLTIIDWSRQHVSQTLFECWAAQAGLYAQFGIAKRAVAHKIFGIYSATSTDVKSPLISGLNAGGLLKMPQSRHTALVMPERLPAGLQVVADNPKVGPLVLSAPKLHAVYVTGHPEYERRTLADEYLRDRRKHLPIQLPEHYFATEQLTTVDYSWQTSSNQLYQNWLATLNLTKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR63</accession>
    <name>F9UR63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101822.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2543"/>
    <dbReference type="EnsemblBacteria" id="CCC79702">
        <property type="protein sequence ID" value="CCC79702"/>
        <property type="gene ID" value="lp_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2543"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2138"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="TCIMITH"/>
    <dbReference type="PhylomeDB" id="F9UR63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2194-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="28960" checksum="B1A78D5DD1A3C4A7" modified="2011-10-19" version="1">MTNSSAPLLSLKNIVTKVNPGTPNEVKILRGLNLDVYDGDFITVLGSNGAGKSTLFNTISGELPVDSGTIQLRDQDITRLSVEKRTAFLARVFQDPKMGTAPRMTVAENLLLASQRGKRRTLKLRQLKKHLSHFQALTETMDGNGLSARLNTATENLSGGQRQALSFLMATEQRPDLLLLDEHTAALDPKTSAQLMTQTNQRVTEEKLTCLMITHHLDDALRYGNRLIVLDQGQIKYDVRDEEKAQLTKEKLLSFFDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR80</accession>
    <name>F9UR80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+/Co2+ transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890233.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2565"/>
    <dbReference type="EnsemblBacteria" id="CCC79719">
        <property type="protein sequence ID" value="CCC79719"/>
        <property type="gene ID" value="lp_2565"/>
    </dbReference>
    <dbReference type="GeneID" id="57025983"/>
    <dbReference type="KEGG" id="lpl:lp_2565"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2155"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_8_0_9"/>
    <dbReference type="OMA" id="TADADHF"/>
    <dbReference type="PhylomeDB" id="F9UR80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2211-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="35054" checksum="10FC40D104812056" modified="2011-10-19" version="1">MIKVHELSDDFRWVAVNNYTENDYHQLVSEEHVTDEMLGYATDQHERGRLEYDAKSAITTIIFDVVTEDVEEGTYTAQVSFMLIDHTLLTFTTDNTIFVEDMLADEIDADWEDVLHPYDHIFNVLYKLSRQYFSAINKINKQRQDIQMKMKKQIQRSVIIQLMDLETTLVYFLTSLKSNNDMLQSLKRFVPVKFSAAQLERLDDIIVEAQQGLEMANIASDIIGRVSNAYSNILDNSLNNTMWVLTIFSIVLTMPNIVFGFFGQNVDLPFMKNPFGWEITVFIAVALCALTIWLLRRNSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR92</accession>
    <name>F9UR92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfatase, alkaline phosphatase superfamily,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LTA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890245.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2580"/>
    <dbReference type="EnsemblBacteria" id="CCC79731">
        <property type="protein sequence ID" value="CCC79731"/>
        <property type="gene ID" value="lp_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2580"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2168"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021310_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2223-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mmb_sulf_HI1246"/>
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    </dbReference>
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        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="251"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
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        <location>
            <position position="303"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="479"/>
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        <location>
            <position position="480"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="717" mass="80923" checksum="4DDEE3D7D4B33DE0" modified="2011-10-19" version="1">MFTKFRQYVNTRIGFFWLLVFLFWAKTIYAYLTEFSLGVADPLQAFLMLVNPIATTVFLFSLAFYIRKTGVYYYILLFIDALDTILLYANVIYHREFTDFMTVSTITGVSKVSQGLTGSSLALASWGDVLYWADIIVILALVILHRIEQDTRPIKKHTAFAYTSAAIAGFGLNLTLAESNRPQLLTRTFDRTYIVKYLGIDAFTVYDGIKDEQTNHQRASAKKSELDTVKDYTESHYAAPNAKMYGLAKGRNVIVIHLESFQQFLIDQKVNGKEVTPFLNKLYHSNSTYSFKNFFHQVGQGKTSDAENMLETSTYGLSTGSLFSQLGSDNTFQAAPAILNQRANYSSAVFHGNVASFWNRNNTYKNMGYQYFFDASYFDTTGDKSTGYGLKDKLLFKNSVQYLERLQQPFYVKYITVTNHFPFTLDKEDTTFKTTDTSDSAINGYFQTAHYLDQSVKEFYTYLQKAGLLKNSMIVLYGDHYGLSNSENSTLAPILGKSADDWTSFDSAQLQRVPFMINIPGIKSGKVESTYGGEIDVLPTILHLLGISSKRYIQFGTDLFSKQHDSTVAFRNRDFVTSKYTVLSGKIYDNATGETIDDDEAVQKTVDKDQKKVDKELSLSDSLNNKNLLRFYTPKGFKKVDASNYNYADGLEKEIQIQNKLAGKSTSLYSKNGNKSTDSLYTTDAPEASHKKTDSTRIKITNPDDTDSTTTSSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_2615</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2615"/>
    <dbReference type="EnsemblBacteria" id="CCC79758">
        <property type="protein sequence ID" value="CCC79758"/>
        <property type="gene ID" value="lp_2615"/>
    </dbReference>
    <dbReference type="GeneID" id="57026019"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="129" mass="14639" checksum="45BFBCC840EC1775" modified="2011-10-19" version="1">MKFDDKVPIYYQIKQYIYHKMIDGTLPPGAKLPAVRQLALDLTVNVNTVQRALSEMITEGTLTSQRGKGNFVTEDQAHIMQLRTTLVNEQLALAYDQLHALNLSDAEIVASLQQYIAQREEHNHDSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE6</accession>
    <name>F9URE6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridylate synthase</fullName>
            <ecNumber evidence="2">4.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluA</name>
        <name evidence="2" type="ordered locus">lp_2653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.70" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101869.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890299.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2653"/>
    <dbReference type="EnsemblBacteria" id="CCC79785">
        <property type="protein sequence ID" value="CCC79785"/>
        <property type="gene ID" value="lp_2653"/>
    </dbReference>
    <dbReference type="GeneID" id="57026045"/>
    <dbReference type="KEGG" id="lpl:lp_2653"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2223"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_8_1_9"/>
    <dbReference type="OMA" id="DRHETQF"/>
    <dbReference type="PhylomeDB" id="F9URE6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2276-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="92"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="33338" checksum="A8C14D5BBB2725CA" modified="2011-10-19" version="1">MTWTYQLTIPSSLNQQSIRACLRTWLIPKRIQGQLRQTRRIQLNGAPTSIAQLVNTGDRLTLTFIPSDFRTPTSNYIAAATAPATILYQNSDLLVVDKPAGVKSHPNQPGETGSILNDLAATLQPTQQVPYMVHRLDQMTSGAMLVALNPVVVPILDRLISDKQIRRTYYAWVRGHFATPTGHFTAPIGHDATDKRKRWVNTADAQPALTDYEVCATTAHQSLVKLTLHTGRTHQLRVHLAASDHPIIGDPLYDSQAESAPRLMLHAQLLDLQLPFSTTRVTVPAPLPSLFEKPHLIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH3</accession>
    <name>F9URH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101881.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890326.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2689"/>
    <dbReference type="EnsemblBacteria" id="CCC79812">
        <property type="protein sequence ID" value="CCC79812"/>
        <property type="gene ID" value="lp_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2689"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2251"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="SIETIRC"/>
    <dbReference type="PhylomeDB" id="F9URH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2303-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="33420" checksum="9D65B8FE45A50ED9" modified="2011-10-19" version="1">MNIKDLQYYVSLTQLKNFSLVAAQFHVSQPTISAAIRRLETELKTQLLIRANPHLPVALTTTGIQVQRHANQILLEHQLMCQEVAHTTTDQLVIGMPPIIEINYFPRIASQLPQALFSQIQPISQGSLAALKGLKNGQLDLAVLAYLNEFTDTTIQLTTFDTQSFSIVVPTDDPLATNSQLQFRSLRHQHFVALKDNFVHRQAFRQLSHQNHVRPTIVFESNEIGSILNMVRQHVGIALLSNAVQLPAGLQRLPLTDAQAPTFNVGVAYRHSMTFSPTQADLIQRLTAAFQSVDWRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ9</accession>
    <name>F9URJ9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">purF</name>
        <name evidence="10" type="ordered locus">lp_2723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890352.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2723"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="CCC79838">
        <property type="protein sequence ID" value="CCC79838"/>
        <property type="gene ID" value="lp_2723"/>
    </dbReference>
    <dbReference type="GeneID" id="57026098"/>
    <dbReference type="KEGG" id="lpl:lp_2723"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2278"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_9"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="PhylomeDB" id="F9URJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2329-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="52399" checksum="6FED3C71AE198B5C" modified="2011-10-19" version="1">MPTEVRSLNEECGVFGVWGSPDAAQLTYFGLHALQHRGQEGAGITANDHGKLQTERGLGLLADVFRDPRRLARLTGQAAVGHVRYATAGNHGLENIQPLSFNFSDSQFALAHNGNLTNAVTLRRRLEQHGAIFHASSDSEILMHLIRRSPAATLTEQVKDALRQVHGGFAYLLLTNDCLIAALDPNGLRPLVVGQLPTGGYVVCSETCALDTIGATFVQDVQPGELLTIDDHGLTIDHYTTDTQLAICSMEFIYFARPDSDIHGVNVHSARKRMGAQLAVEQPVDADIVVGVPNSSLSAATGYAEASGLPYEMGLIKNQYSSRTFIQPTQALREQGVRMKLSAVKGVVAGKRVVLIDDSIVRGTTSRRIVKLLKDAGAKSVHLRIASPPLRYPCFYGIDIQSTNELIAAQQTIREMCQTFGADSLGFLSEQGVVDAVGLSTTEPYGGLCMAYFNGDYPTALYDYQAEYDAEIAQLQANHEGVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM3</accession>
    <name>F9URM3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79862">
        <property type="protein sequence ID" value="CCC79862"/>
        <property type="gene ID" value="lp_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2749"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2302"/>
    <dbReference type="eggNOG" id="ENOG5030A8F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193619_0_0_9"/>
    <dbReference type="OMA" id="MLTQITA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2353-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="12614" checksum="FBD9810DBD9D1215" modified="2011-10-19" version="1">MTFTNQETDYLMNLLTNQLMALLSRVTRWQTHSLSQHQYDQQVHETLQPELTMLTQITAKLQGQARDQTQLGAIQTGLKKLQVATTYQLTADQLAHANERRLNRRYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU0</accession>
    <name>F9URU0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase, HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644753.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2835"/>
    <dbReference type="EnsemblBacteria" id="CCC79929">
        <property type="protein sequence ID" value="CCC79929"/>
        <property type="gene ID" value="lp_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2835"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2371"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_9"/>
    <dbReference type="OMA" id="LIQWDEG"/>
    <dbReference type="PhylomeDB" id="F9URU0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2426-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="25376" checksum="24F5622ACD495570" modified="2011-10-19" version="1">MTKKYLTFDCYGTLINTEPLYQWVANLGLAVGLDPLTVRKAYATYEDDPASVNPYLDYSTLVRADLKHLDRLFEQRHFFESHYVECLEVQRHLLPYADVIPTLTAWQQLGYQLIIMSNSSWDIMPANIAALKVSFTAVVTAEDIQAYKPALAFFETVQERFKLTADNHWHIARGYESDVVPASAMQWPMIWINRDQRQPTSSERPTHMVTDLAAVKQWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY8</accession>
    <name>F9URY8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2894"/>
    <dbReference type="EnsemblBacteria" id="CCC79977">
        <property type="protein sequence ID" value="CCC79977"/>
        <property type="gene ID" value="lp_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2894"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2421"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_9"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="PhylomeDB" id="F9URY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2474-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79977.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="583" mass="64196" checksum="FE02D066B9A84CA6" modified="2011-10-19" version="1">MSIFLKLGWYFRREWKLYLAGVLGLVLTAIIGIVPPRIIGDVVDGINQHSLTAHTLTVYLVIIGVAAVGQYLARYLWRNAIWGGAAGLERTLRERLFWHFMKMDATFYQQYRTGDLMAHATNDLTAVERVAGGGILQFADSIITGGTTLIAMMTLIDWRLTLIAVVPFPLLAVVSRYLGKKIHVAFRASQAAFSRLNNKAQESISGIKVIKALGQEKADVADFNQQIDQTIKINRHVNVLDSLFDPAITMIIALSYGATIILGGLYVTHGVITIGNLVSFVTYLGMMVWPMFAVGMLFNTMERGNASYDRVMELLNQQSAIIDAKRGIEQRPHGDIQYQIKQFNYPNDAGTSLSNVDFTLKAGQTLGIVGRVGAGKSTIMKLILREFDQYEGHITYGGHDIKQYALDSYLPALGYVPQDSFLFSNTIRENIRFADPTVSQAVVEAVAAKSDLSGQIASMPAGYDTQVGEEGISLSGGQRQRLAIARALLINPELLILDDALSAVDAETEAEILANLKAERADKTTIIAAHRLSSVMNADEIIVLDAGHVVERGTHAQLMTQHGWYQKMFTRQQLETKVEGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
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    <name>F9US04_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
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    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2917"/>
    <dbReference type="EnsemblBacteria" id="CCC79993">
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        <property type="gene ID" value="lp_2917"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="F9US04"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="35"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="404" mass="43496" checksum="58C8C7B9DF8DBE98" modified="2011-10-19" version="1">MLTLLKNRTLQTIASANFFTTLGVSLFNIILLTYAKNFPNPHWFVAIVSVVTVVPYVFGGLTGRLADQTRRKTNWLIGTKVVQAGLYLVLAQVITQQTVVVFYVVVAINFISDLLGRYGGSILTIVIQDRIGPDDRQQVMGLNASVSTLVEPLGQTLGVLIIAQWHDYALAGIVNAMTFIGAASCLLAGRSAIQSTPKVAVRPRHIEAWPVIQRVMLTTTRMGAVSYLGILMILNVATMSIDAILNLMFIDLASRMPVSYSVAILMVNVVFVTGSVLGGITKNTWFDRLSLFQLLLAAILAPMLTYVTLLVVPQLILILGGMFAVGFMSGKLDPKMFAIMMPQIDPHLTGTVFGTISSIVTLAAPVGSVGIVLLYNLVGATAACSVMIGVSALALIWAVMAHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9US57</accession>
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        <submittedName>
            <fullName evidence="4">Kojibiose-like phosphorylase, specific</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0028</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC77604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
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        <property type="protein sequence ID" value="CCC77604"/>
        <property type="gene ID" value="lp_0028"/>
    </dbReference>
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    <dbReference type="KEGG" id="lpl:lp_0028"/>
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    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="WIPDNSR"/>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:organic substance catabolic process"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="3">
        <location>
            <begin position="126"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="1">
        <location>
            <begin position="427"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="2">
        <location>
            <begin position="846"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="906" mass="102193" checksum="D8F5387602A8753E" modified="2011-10-19" version="1">MKLIRLRIENDAMDIAYHPVSGQAATAHYLIAYNSDQTIGENLENIKVRLAGLQFDAAILENGLSYPFSDTIVGVNYDRIDVGLALTNLLNIPVVSQAAVDQLGLVAAVKAKSAYLKWHLDYYGQYHGVRNNGQEAMLTIGNGYFGLRGAFLESHADKDNYPGTYVAGVYDQTTTTVHDHQVKNEDLVNLPNAQFMTFGIDHQTPFTLNEHDLQDAYRSLDLKTGLLTTTKLIQLASGHQLRIRSQKVANMRDWHRYSIRYQVTPLNFAGSLQIYTEIDGSVVNSNVSRYNVFDQHHLKTMGIETAANTVYLSGQTKSSHINYTIGAKLTSPDVPAIENFNSTQQPQGVQQTVSLAVEAGKTYTFDKNVVIATSNDHSDPQLTHVQAELDQSSFDNTVTTSKDYWEATWRATDIKIRGDITSQRLLRVNIYHSFVSAAAIESGQLDASVGARGLHGEAYRGHVFWDEMFILPFYTLHRPELAKQLLAYRYRRLPMARKNAEAEGYAGAMYPWQSASKGDEQSQFTHLNPITKTWDPDNSRLQRHVSLDIAYNVWFYYHVTQDRDFLTHYGMEMLLSIAAFWISKADYDQANGRYNISGVMGPDEFHENYPNSTTAGLKNNAYTNIMVAWLFDTITTLRAQMPQAAFQAAAQAAQFDSTAEQALTTISHQLTLEINRRGIIAQFEGYFNLPTLDFQAYRQKYGDIARMDRILKAESKTPDAYQVAKQADALMAFYNFDVTTVQKIIEKMGYQLPKEYLTHNIQYYLARTTHGSTLSRIVYAVLNQLDDNDDDAWKLFSEALASDYYDIQGGTTAEGIHLGVMCATLNLTTRNFGGVNPLGAHLQVNPRLPEHWQTLKFKHLFRGVHYVFVIDHQRVTVTADQPSTIMIGKQHYQLQAKKPLSVTYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD3</accession>
    <name>F9USD3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3004"/>
    <dbReference type="EnsemblBacteria" id="CCC80063">
        <property type="protein sequence ID" value="CCC80063"/>
        <property type="gene ID" value="lp_3004"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3004"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2508"/>
    <dbReference type="eggNOG" id="ENOG5030A7B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246583_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2557-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11641" checksum="16941B0C20A82433" modified="2011-10-19" version="1">MQQLTPLAAYSDLAFDWSIVINEGAAGLTTIRQHLAATLSDCLAAHVTILCRPAMFFLIIHDHRQKVAIPGHIYPGTEQPYEIQLDGWPVNNSTAFMTIIHKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD5</accession>
    <name>F9USD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system, cellobiose-specific EIIA component</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pts23A</name>
        <name evidence="5" type="ordered locus">lp_3008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890579.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3008"/>
    <dbReference type="EnsemblBacteria" id="CCC80065">
        <property type="protein sequence ID" value="CCC80065"/>
        <property type="gene ID" value="lp_3008"/>
    </dbReference>
    <dbReference type="GeneID" id="57026335"/>
    <dbReference type="KEGG" id="lpl:lp_3008"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2511"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756542_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2559-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="4">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="148" mass="15487" checksum="E3A674DF157A7ABD" modified="2011-10-19" version="1">MGLFSFGKKVKLYAPVDGTLIDLATVAAGQTGFAVTPERHHIFSPVTGTVSALIPEQNAIELAAGKLTVRLRMGVNTSATPATYVHEGDQVTPETPLAFVDQEQAAENGEDMTVLVVVDKGGQPAEKISLSTSGQVSHDQEVATVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD6</accession>
    <name>F9USD6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system, cellobiose-specific EIIB component</fullName>
            <ecNumber evidence="6">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pts23B</name>
        <name evidence="6" type="ordered locus">lp_3009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3009"/>
    <dbReference type="EnsemblBacteria" id="CCC80066">
        <property type="protein sequence ID" value="CCC80066"/>
        <property type="gene ID" value="lp_3009"/>
    </dbReference>
    <dbReference type="GeneID" id="57026336"/>
    <dbReference type="GeneID" id="66450603"/>
    <dbReference type="KEGG" id="lpl:lp_3009"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2512"/>
    <dbReference type="eggNOG" id="COG1440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147323_1_1_9"/>
    <dbReference type="OMA" id="YAIPEQN"/>
    <dbReference type="PhylomeDB" id="F9USD6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2560-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389089" evidence="4">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="11702" checksum="F9FA3F7A5EE2FB18" modified="2011-10-19" version="1">MAEKIIMLACSAGMSTSLLVSKMEAAAKQDGVDYKIFATSAADIDHQLSQDPHPDVLLLGPQVRYMANDVKKKTDKAGIPMDIINMSDYGMMNGENVLQAAEKLLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD9</accession>
    <name>F9USD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase protein family</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3012"/>
    <dbReference type="EnsemblBacteria" id="CCC80069">
        <property type="protein sequence ID" value="CCC80069"/>
        <property type="gene ID" value="lp_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3012"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2515"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_9"/>
    <dbReference type="OMA" id="RYILGHQ"/>
    <dbReference type="PhylomeDB" id="F9USD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2563-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="36391" checksum="215625377C6FB257" modified="2011-10-19" version="1">MNKSLVLVTGGNGFLASHIIKQLLTAGYPVRATLRSLDKAAGVKQTLAGTPNLDRLTFVALDLTQDQGWAEAMRDVTYVMSVAAPVFVNQGQASDEVTSAAKVGTIRVLKAATAAGVKRVVMTANLGAVGFSRLDHDHPVTEVDWTREDQPGLSLYEKSKLVAEEAGWAYCKAHADSPEFTTVNAGAMLGPSLNGHVTGSYNLVSRILTGQMMPNLKVNVIDVRDVADLEVRAMTAPAAANQRFLAVAATPISMRDLKTLIQEQRPQLAAGLTKHLIPDWFVRGLAPFSGQLRESSLMIRINHEVSTQKAQQLLGWQARSADTAVLAAVDTLVKNGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK2</accession>
    <name>F9USK2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system histidine protein kinase sensor protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lamK</name>
        <name evidence="3" type="ordered locus">lp_3088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890646.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3088"/>
    <dbReference type="EnsemblBacteria" id="CCC80132">
        <property type="protein sequence ID" value="CCC80132"/>
        <property type="gene ID" value="lp_3088"/>
    </dbReference>
    <dbReference type="GeneID" id="57026399"/>
    <dbReference type="KEGG" id="lpl:lp_3088"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2579"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046138_1_2_9"/>
    <dbReference type="OMA" id="GILMDNA"/>
    <dbReference type="PhylomeDB" id="F9USK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2625-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="311"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="416" mass="47701" checksum="B683175ABDC98F8C" modified="2011-10-19" version="1">MKIIFVQTLFLFLFVKVLLRDWRVLSIWDISYAVVSSLVSGWIFSVIGQYAALPLLGLVVLFTWWHTHSFSESLFVSLQVIIWSIVVDHISSLLTYMLKLDDGYLLIFMGLQLVGLITLNLILMNTHIQTTFNRPRLNRVTALLLLAIYLYIIVSEGLDSELRMVVSNLVVLLVVMGLAIAIYDEYRVTIRAKYQVQQQRLQIKNDTRYMHEIETHYNELRRFRHDYQNIMLSINEYLKTDDLAGLQQYYQQNIAPVTKRVSDEQYNLEDLSRVQVKSVKSILFSKLSYAQSQGVKVQFDLKQVLNGVTTNELDLAIALGIILDNAIEATAGHYHGELMSAIFVTAHSTVFLVQNNVFDSLPPLWQLKEAGYSTKGQERGLGLSQLSAIVNRNENMILETRLLASAFVQRLTVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK3</accession>
    <name>F9USK3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Auto-inducing peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890647.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3089"/>
    <dbReference type="EnsemblBacteria" id="CCC80133">
        <property type="protein sequence ID" value="CCC80133"/>
        <property type="gene ID" value="lp_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3089"/>
    <dbReference type="HOGENOM" id="CLU_3253308_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2626-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="42" mass="4874" checksum="461E5A877947F16A" modified="2011-10-19" version="1">MVQWAKRFSETKEPVVLISHNQNRCAGKIVVLMMSRLELWGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST4</accession>
    <name>LARE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase</fullName>
            <ecNumber evidence="3">4.4.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase accessory protein LarE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase activation protein LarE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase maturation protein LarE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 8">Lactate racemization operon protein LarE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nickel-pincer cofactor biosynthesis protein LarE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase</fullName>
            <shortName evidence="7">P2CMN sulfurtransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">larE</name>
        <name evidence="8" type="ordered locus">lp_0109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6750" last="6761">
            <title>Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Goffin P."/>
                <person name="Deghorain M."/>
                <person name="Mainardi J.L."/>
                <person name="Tytgat I."/>
                <person name="Champomier-Verges M.C."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="16166538"/>
            <dbReference type="DOI" id="10.1128/JB.187.19.6750-6761.2005"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="5598" last="5603">
            <title>Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
                <person name="Hausinger R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27114550"/>
            <dbReference type="DOI" id="10.1073/pnas.1600486113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>REACTION MECHANISM</scope>
        <scope>ACTIVE SITE</scope>
        <scope>MUTAGENESIS OF ASP-30 AND CYS-176</scope>
        <scope>DIDEHYDROALANINE FORMATION AT CYS-176</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54788"/>
            <dbReference type="Rhea" id="RHEA-COMP:13982"/>
            <dbReference type="Rhea" id="RHEA-COMP:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:137353"/>
            <dbReference type="ChEBI" id="CHEBI:138330"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.4.1.37"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54892"/>
            <dbReference type="Rhea" id="RHEA-COMP:13982"/>
            <dbReference type="Rhea" id="RHEA-COMP:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:137372"/>
            <dbReference type="ChEBI" id="CHEBI:138330"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.4.1.37"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="1 2">Induced by L-lactate and repressed by D-lactate. Is thus regulated by the L-lactate/D-lactate ratio. Makes part of the lar operon (larABCDE).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Deletion of this gene leads to a loss of lactate racemase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LarE family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.37" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888179.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="5UDQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.09 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.62 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.19 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.79 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.62 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UDX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.78 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="5UNM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.58 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6B2M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.09 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6B2O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6DG3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6UTP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.55 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6UTQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.39 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6UTR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.41 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDB" id="6UTT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.49 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-276"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UDQ"/>
    <dbReference type="PDBsum" id="5UDR"/>
    <dbReference type="PDBsum" id="5UDS"/>
    <dbReference type="PDBsum" id="5UDT"/>
    <dbReference type="PDBsum" id="5UDU"/>
    <dbReference type="PDBsum" id="5UDV"/>
    <dbReference type="PDBsum" id="5UDW"/>
    <dbReference type="PDBsum" id="5UDX"/>
    <dbReference type="PDBsum" id="5UNM"/>
    <dbReference type="PDBsum" id="6B2M"/>
    <dbReference type="PDBsum" id="6B2O"/>
    <dbReference type="PDBsum" id="6DG3"/>
    <dbReference type="PDBsum" id="6UTP"/>
    <dbReference type="PDBsum" id="6UTQ"/>
    <dbReference type="PDBsum" id="6UTR"/>
    <dbReference type="PDBsum" id="6UTT"/>
    <dbReference type="AlphaFoldDB" id="F9UST4"/>
    <dbReference type="SMR" id="F9UST4"/>
    <dbReference type="STRING" id="220668.lp_0109"/>
    <dbReference type="DNASU" id="1061362"/>
    <dbReference type="EnsemblBacteria" id="CCC77665">
        <property type="protein sequence ID" value="CCC77665"/>
        <property type="gene ID" value="lp_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="57026951"/>
    <dbReference type="GeneID" id="66448249"/>
    <dbReference type="KEGG" id="lpl:lp_0109"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.89"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_9"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="PhylomeDB" id="F9UST4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-87-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-20306"/>
    <dbReference type="BRENDA" id="4.4.1.37">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="DisProt" id="DP01168"/>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000441655" description="Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of activity." evidence="3">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="30"/>
        </location>
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    <feature type="mutagenesis site" description="Loss of activity." evidence="3">
        <original>C</original>
        <variation>A</variation>
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        </location>
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    <feature type="helix" evidence="14">
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            <end position="46"/>
        </location>
    </feature>
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            <begin position="47"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5UDT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="5UDW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5UNM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6B2M"/>
        </source>
    </evidence>
    <sequence length="276" mass="30484" checksum="94B4C899BBAD22EE" modified="2011-10-19" version="1">MATLATKKATLVAALKDLQRVTVAFSGGIDSTLVLKMALDVLGRDNVTAVVANSELFTDEEFDKAMSLAEELGANVQGTTLDYLSDDHIKNNTPDSWYYAKKMFYSRLNDIAANNGSAAVLDGMIKNDENDYRPGLKARSEAGARSLLQEADFFKTDVRALAQELGLTNWNKVASCSVSSRFPYGTTLTHDNIAQVMAAEKYLRSLGFPTVRVRFHNDIARIELPEARIGDFLVFNDRVNRQLQSLGFRYVTLDLGGFRSGRMNDTLTKAQLATFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY2</accession>
    <name>F9USY2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dak3</name>
        <name evidence="6" type="ordered locus">lp_0170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0170"/>
    <dbReference type="EnsemblBacteria" id="CCC77713">
        <property type="protein sequence ID" value="CCC77713"/>
        <property type="gene ID" value="lp_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="57027000"/>
    <dbReference type="KEGG" id="lpl:lp_0170"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.138"/>
    <dbReference type="eggNOG" id="COG3412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045361_1_0_9"/>
    <dbReference type="OMA" id="SFDHVQV"/>
    <dbReference type="PhylomeDB" id="F9USY2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-135-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
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        <property type="entry name" value="DhaM_N"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="5">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="12839" checksum="7E9B220F8C404B80" modified="2011-10-19" version="1">MSLGIVVVSHVPEIAAGIQRLLGQVAQDVSITIAGGTDDNQVGTSLTKITQAFDANHADELLAFYDLGSAKMNLEMAIEMSDKTVHLYDTALIESAYTAASLLQAAVPLADVEAQLAPLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY7</accession>
    <name>F9USY7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdxE</name>
        <name evidence="5" type="ordered locus">lp_0175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100909.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888232.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0175"/>
    <dbReference type="EnsemblBacteria" id="CCC77718">
        <property type="protein sequence ID" value="CCC77718"/>
        <property type="gene ID" value="lp_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0175"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.143"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_2_9"/>
    <dbReference type="OMA" id="WAHDWIG"/>
    <dbReference type="PhylomeDB" id="F9USY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-140-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013430682" description="Maltodextrin-binding protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="417" mass="45668" checksum="61E31AA770020E7D" modified="2011-10-19" version="1">MSTWKKLGMGALATGLALTLVGCGNSKSSSSSSKMDKTLKVSADPSYKSYMKSVIPKFEKKYNVKVKVSYKAMLDEDDALKLDGPSGKGPDVLMAPYDRVGQMASQGQLSTVKLTSGRYNATGKKSVTYKNKVYAAPVTIESDVLYYNKKLIKTAPKNFKELEKLASDKKYAYANDKTKSVAFLTQWTNFYNAFGVIKGYGGYVFADGNTNAKKMGLNNSGAVEGLTYMTKWFTKYWPSGMQNVTSNENFVTSQFTSNKTAAVIDGPWMAATYKKSNIDYGVAVLPKLNNGKDYQAFAGGKAWAISNYSKHKTAAQAWLDFISNKTNQNKLYKSASEIPANTAARKEAVSTGDDMATAVSKQYDKDVPLINLPQMSEVWTPAQTMVTNDASGKMTPKQAANKAQKTILTNISQKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ2</accession>
    <name>F9USZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltodextrin ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">msmX</name>
        <name evidence="6" type="ordered locus">lp_0180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641775.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888237.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0180"/>
    <dbReference type="EnsemblBacteria" id="CCC77723">
        <property type="protein sequence ID" value="CCC77723"/>
        <property type="gene ID" value="lp_0180"/>
    </dbReference>
    <dbReference type="GeneID" id="57027010"/>
    <dbReference type="KEGG" id="lpl:lp_0180"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.148"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_9"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="PhylomeDB" id="F9USZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-145-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="368" mass="41304" checksum="6584DEF9C943F046" modified="2011-10-19" version="1">MVEMNLDHIYKKYEGNDKYSVTDMNLDIKDGEFIFFIGPSGCGKSTTLRMIAGLEDITKGDFKMNGQVMNDVEPKNRDIAMVFQTYALYPNMSVFDNMAFGLKIRKTYSNTEIKKRVDNAAEQLGLTDYLQRKPANLSGGQRQRVALGRAIVRDAGTFLLDEPLSNLDAKLRVDMRTTIAQMHQRLKTNMIYVTHDQIEAMTMADRIVIMNDGKIMQVGTPHELYNEPVNQFVAGFMGSPSMNFFNATLHDGRVTDGEGLDVAVPEGQLKVLKAQGYDQKKMIVGIRPEDIHAEQIALEAMSDSIVKTKVVVSEFLGAESMLYCTAGKSKFTAQVDARDYHNPGENVEVAFEMSKAHFFDSETKDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ4</accession>
    <name>F9USZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="8">3.2.1.96</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100911.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USZ4"/>
    <dbReference type="STRING" id="220668.lp_0182"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="CAZy" id="GH85">
        <property type="family name" value="Glycoside Hydrolase Family 85"/>
    </dbReference>
    <dbReference type="DNASU" id="1061453"/>
    <dbReference type="EnsemblBacteria" id="CCC77725">
        <property type="protein sequence ID" value="CCC77725"/>
        <property type="gene ID" value="lp_0182"/>
    </dbReference>
    <dbReference type="GeneID" id="57027012"/>
    <dbReference type="KEGG" id="lpl:lp_0182"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.150"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008357_0_0_9"/>
    <dbReference type="OMA" id="AYGFDGW"/>
    <dbReference type="PhylomeDB" id="F9USZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-147-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389017" evidence="5">
        <location>
            <begin position="31"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="7">
        <location>
            <begin position="718"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="797"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="948" mass="104458" checksum="2459730302D4BFD3" modified="2011-10-19" version="1">MRHGQYRYIVGTLALITTAVGLVACSKQSANQQISYRQTAEATLDKGMDNQPEAPYWFPKQLLKWQLSKDKAAKYNTASVPLAKRIDKWQLPTVNKTQDPKMKVVALSIMNSSTSGNAPRGINTFDANVFSNWQYIDQLVYWGGSAGEGLIVPPTADVIDSAHKNGVPVLGTVFFPQVVSGGKLKWLNDFLKQDADGHFPMADKLVAVAKAYGFDGWFINQETDPEVKSFDSASTGKTATSSTSNGLSKKHAQLMQQLIKEYKQKAGSKLDLMWYDSMTKDGKMDWQNALTKENQSYLVDANMKPVADSMFLNFWWTKKRLASQELLKKSHERAEKLGISPYNLFAGIDVQADGTATPVRWNLFANKQHVPYTSLGLYAPDWTHASSDTVDEFQAKEGALWVNDQNDPSRSIPSTTSTHWPGVSTYAVEQSAITKQPFVTNFSLGNGYNYFIKGKNVSLRDWNNRSLQAVNPTYRWLINNGNGNALKASFDYTDAYEGGNDIKLAGKMRKDTASTIKLYTTDLDVTADTQVSLTAKASGKSTAKLVVTLKDGRTKTIAGDRTLSKHWTTVSYDVSQLTKKTIKGLSLKISAAETDASYSVQLGRLAITGKQQAAPKKVNQVTIDNRTFDEEGKYAGVNLSWQATTKNKLDHYEIYQVNNDGSRSFLGATNTTNFYLNALKRNGQHNETNLMVVPVDIWNQRGDASDQVTLKWPDNRKPKAAFTVNRTLAAPGNTIKFTNASSKNATSYKWEFDGATKTTSTAKNPTVTYRKAGTYNVTLTAKNKDGQRHVTMKKLITITPKAQGALTLLSKNAKTSASGYTNSSEAPKMAVDGKLDTKWCATGKAPHTLTLDLGRQTTVSAVKLAHAKAGGEGADMNTRAWTIQVSTDGKRYTDVARTYNNTQATSLNTFAATSARYVRLVVDKPTQVADTAVRIYEMDVLGLTQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT34</accession>
    <name>F9UT34_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, mannitol-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts2A</name>
        <name evidence="2" type="ordered locus">lp_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641824.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888279.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0232"/>
    <dbReference type="EnsemblBacteria" id="CCC77765">
        <property type="protein sequence ID" value="CCC77765"/>
        <property type="gene ID" value="lp_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="57027055"/>
    <dbReference type="GeneID" id="66448342"/>
    <dbReference type="KEGG" id="lpl:lp_0232"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.193"/>
    <dbReference type="eggNOG" id="COG4668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_3_0_9"/>
    <dbReference type="OMA" id="EDYIQAM"/>
    <dbReference type="PhylomeDB" id="F9UT34"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-187-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="16138" checksum="4C589A75E3EB177D" modified="2011-10-19" version="1">MEALDKKMIALNQQVATQEEGIRLAGQLLVDGGCVEPEYIDAMQARNQDVSVYMGNFIAIPHGTEDGMKYIKKTGISVVQVPMGVSWGNPDDNDDDKTVTVIFGIAGLNGEHLNLLSQIAIYCSDVANVAKLADAQSEDEIINLLKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT46</accession>
    <name>F9UT46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100934.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888291.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0248"/>
    <dbReference type="EnsemblBacteria" id="CCC77777">
        <property type="protein sequence ID" value="CCC77777"/>
        <property type="gene ID" value="lp_0248"/>
    </dbReference>
    <dbReference type="GeneID" id="57027067"/>
    <dbReference type="KEGG" id="lpl:lp_0248"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.204"/>
    <dbReference type="eggNOG" id="ENOG5030AX4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465161_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-199-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9746" checksum="FBE101862F29D2B0" modified="2011-10-19" version="1">MFGILILAAFVIGSEWLVSRGVMPAYLIKARTGQTLWRALLSILVTVGLVGWLHLPAVIAIVVTIYFATIIANRYLQVFEAMERGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT97</accession>
    <name>F9UT97_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bar</name>
        <name evidence="2" type="ordered locus">lp_3187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642421.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3187"/>
    <dbReference type="EnsemblBacteria" id="CCC80215">
        <property type="protein sequence ID" value="CCC80215"/>
        <property type="gene ID" value="lp_3187"/>
    </dbReference>
    <dbReference type="GeneID" id="57026477"/>
    <dbReference type="KEGG" id="lpl:lp_3187"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2663"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_4_3_9"/>
    <dbReference type="OMA" id="IFAHNQP"/>
    <dbReference type="PhylomeDB" id="F9UT97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2703-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="165" mass="18489" checksum="4B215DA9002827FA" modified="2011-10-19" version="1">MSVSLRTATMSDLPIIVDIYNQTIPSHQVTADLKPVTVEQRRNWFLSHTPEHYPLWVVVKDDSVVGWVSLSPFYGRAAYAKTTEISVYLDRSVQGQGIGSQVLTLVPKQLPVLGLTTIIAYIFSSNIPSIKLFKKFGYEQWGFLPEVAELGGRPNDLVILGQHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB6</accession>
    <name>F9UTB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3210"/>
    <dbReference type="EnsemblBacteria" id="CCC80234">
        <property type="protein sequence ID" value="CCC80234"/>
        <property type="gene ID" value="lp_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3210"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2682"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_9"/>
    <dbReference type="OMA" id="QWEAGYS"/>
    <dbReference type="PhylomeDB" id="F9UTB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2722-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="26136" checksum="20C679610C06EF75" modified="2011-10-19" version="1">MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIANFYVWLFRSTPLLVQLFIVYFGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETIRAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLPPLSNSFISLVKDTSLAASITIIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG2</accession>
    <name>F9UTG2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">purB</name>
        <name evidence="13" type="ordered locus">lp_3269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890794.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3269"/>
    <dbReference type="EnsemblBacteria" id="CCC80280">
        <property type="protein sequence ID" value="CCC80280"/>
        <property type="gene ID" value="lp_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3269"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2729"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_9"/>
    <dbReference type="OMA" id="ASSCEKI"/>
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    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
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        <property type="entry name" value="Pur_lyase"/>
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    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="ADSL_C" evidence="12">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
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    <accession>F9UTI0</accession>
    <name>F9UTI0_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">lp_3292</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004890812.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80298">
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        <property type="gene ID" value="lp_3292"/>
    </dbReference>
    <dbReference type="GeneID" id="58789817"/>
    <dbReference type="KEGG" id="lpl:lp_3292"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2748"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="6190" checksum="353B17AA4D5B49DF" modified="2011-10-19" version="1">MSIINRVIGIIITLILLCQWLLGYQLPAAMAFFLVAWLIGLVTMWLLPDSTTANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM3</accession>
    <name>F9UTM3_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890855.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_3350"/>
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    </dbReference>
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    <dbReference type="GeneID" id="66450867"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CCC80341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="121" mass="13989" checksum="690880EB7A0E9871" modified="2011-10-19" version="1">MATVHAEAKAELLRQYQEIVTKYLTNISETVDVKAHFELKNEPGFNYFVDYLFLANVCYQASLDILNNEDQKYPDINKRLAAVILKYPEYLTLAVFNADFQDESVTDHYEKTLVDLANTLD</sequence>
</entry>
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    <accession>F9UTQ5</accession>
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100955.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888339.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0300"/>
    <dbReference type="DNASU" id="1061141"/>
    <dbReference type="EnsemblBacteria" id="CCC77825">
        <property type="protein sequence ID" value="CCC77825"/>
        <property type="gene ID" value="lp_0300"/>
    </dbReference>
    <dbReference type="GeneID" id="57027112"/>
    <dbReference type="KEGG" id="lpl:lp_0300"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.253"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119056_0_0_9"/>
    <dbReference type="OMA" id="WDATIVL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-247-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="28686" checksum="268D4F713143F38E" modified="2011-10-19" version="1">MSSTKRGWGAAISIFILVPILFKLIAWLPVPTLYSGLVQDLLVLLIFLLLNHFWFKISIQWWQSQSLVRQCLQLIPGIIILLLPMTSNFIKLCHLAWTPTLILYIGYALVIGITEEYIYRGMLLPLLRQCFPHRLMLAICIDSLLFGLTHLLINSSQLTLSYVIPQVFYAAAGGLIFCGLYLRTNNLVWPIFLHALSDVSVVVSLATHTHTAAKLSIPVAYAIGISVLYLVLFIIIAFIVRWQVRPQKRLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU20</accession>
    <name>F9UU20_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">lp_0434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888454.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0434"/>
    <dbReference type="EnsemblBacteria" id="CCC77940">
        <property type="protein sequence ID" value="CCC77940"/>
        <property type="gene ID" value="lp_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0434"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.354"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_1_9"/>
    <dbReference type="OMA" id="LGHYFGT"/>
    <dbReference type="PhylomeDB" id="F9UU20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-361-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="338" mass="37614" checksum="C554933437EEE362" modified="2011-10-19" version="1">MTKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIRKSLLQVAMDYLAVGIDPQKSTILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQKAFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLEQTREIVRSFNKTYQTDTLVEPEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGKVEGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYEADPAQVLQILKDGTAKANVVADQTWREMQDAIGINYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU53</accession>
    <name>F9UU53_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug transport protein, major facilitator superfamily (MFS), EmrB/QacA subfamily, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lmrB-N</name>
        <name evidence="10" type="ordered locus">lp_3368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3368"/>
    <dbReference type="EnsemblBacteria" id="CCC80355">
        <property type="protein sequence ID" value="CCC80355"/>
        <property type="gene ID" value="lp_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3368"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_9"/>
    <dbReference type="PhylomeDB" id="F9UU53"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="371" mass="39438" checksum="AC9420EFA370B84A" modified="2011-10-19" version="1">MNNIMDSVQSSPQAKQRARVPVAHPMLAMMGMLIGGFVGMFSETSLNIALPQLMAQLHVSTATVQWLVTGYMLMIGIVLPLSSLITKWFTTRQVILFALIDFAVGAIISASAPGFGVLLFGRMIQGIATGLILPLMFTVAMQIFPPYKLGAAMGMVGLVIMFAPAVGPTIAGAILGLASWRWIFWLFIPFLIIAFIFAVTSLKNIAKVTRPKVDFLSILLSMVGFGSLVVGVSLASDQGWGSPAVLGALILGLVILAWYAHRQLTMESPILNLKTSAIPGFRVGACLVMINFGIILSAMYLLPMYIQKGLLIPVALTGVIMLPGGLMNAIVSAVSGRLYDSIGARTPAMLGFLISMVGALMLALTTTQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU80</accession>
    <name>F9UU80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional protein: 2',3'-cyclic-nucleotide 2'-phosphodiesterase 3'-nucleotidase</fullName>
            <ecNumber evidence="4">3.1.3.6</ecNumber>
            <ecNumber evidence="4">3.1.4.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpdB</name>
        <name evidence="4" type="ordered locus">lp_3400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.6" evidence="4"/>
    <dbReference type="EC" id="3.1.4.16" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890896.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3400"/>
    <dbReference type="EnsemblBacteria" id="CCC80382">
        <property type="protein sequence ID" value="CCC80382"/>
        <property type="gene ID" value="lp_3400"/>
    </dbReference>
    <dbReference type="GeneID" id="57026628"/>
    <dbReference type="GeneID" id="66450892"/>
    <dbReference type="KEGG" id="lpl:lp_3400"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_4_4_9"/>
    <dbReference type="OMA" id="EKAQYPM"/>
    <dbReference type="PhylomeDB" id="F9UU80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2869-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="320"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="516" mass="57922" checksum="3952AF2A2E8BEFAF" modified="2011-10-19" version="1">MKIKLISTSDVHGYLAPTDYSRRDNIAPFSLSRAATVIHQLSREDTADVWPIVIDNGDYVQGSPLTYFIARHHQEAAPLYSRLANCNHVQAGIFGNHEFNYGLDYLDLCESSRQYPMLAANIHDDLHRTLFSKPYTILERAGVKVAILGLTTQFVAHWEQPHHIAGLHFEDVVATAKHWVPKLRQLADVVVIAYHGGLERDPQTDRPTERMNGENRGSALLAEVPGIDAMITGHQHRQLAVTVHGVPVTQPGMKGTNVAMITLELDRNHQVTTSHPEIYPVADATPNTQVMQLVGPINDQMEDWLDTPLGQINGNMLVHDHLQARLHNHPYIDFINRVEMAATGTDIAATALFNDDVPGLKQHVTMREVMNSYVYPNKLAVEAITGADLRAALERCASYFLLQDGHVRVNPEFMHPKLRHYVYDIYSGIDYTFDLTKPFGQRVVQLDYHGAPVTADQKLTVTLNHYRAGGGGNYPMYQTAKIIRRLPTDMTVLIADYFAQHPVVNATQPTNFQVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA8</accession>
    <name>F9UUA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890924.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3430"/>
    <dbReference type="EnsemblBacteria" id="CCC80410">
        <property type="protein sequence ID" value="CCC80410"/>
        <property type="gene ID" value="lp_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3430"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2858"/>
    <dbReference type="eggNOG" id="COG2837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044178_0_0_9"/>
    <dbReference type="OMA" id="CAEPNLH"/>
    <dbReference type="PhylomeDB" id="F9UUA8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2898-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="317" mass="35960" checksum="3D66DF012563A517" modified="2011-10-19" version="1">MPINPNRAQDVWKDVGEHVQFTVLQLNRQDQQHDREVFQEFADRSQAIIRSLRIRDAKPETGTQLKVSIGISSAAWDYLFPGAPKPKELETYTTLSGPKYTMPATPGDLFFHIRASNEAVVYECQTQFQRVLAPITTVLDETKGFRYFEGRAIIGFIDGTEAPAVEDAADYALVGDEDPQFINGSYAFAQKWQHDMPVWEHMHTEDQEKAVGREKFSDFELEDEDKFKNAHNVASKLEIDGVEQKIVRMNVPYSNPAAGNTGTYFIGYARHWTVTKGMLQNMVDQSDFLLTFSTLLSGQAFFIPSRDLLAQIADDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC7</accession>
    <name>F9UUC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein (Putative)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102170.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3454"/>
    <dbReference type="EnsemblBacteria" id="CCC80429">
        <property type="protein sequence ID" value="CCC80429"/>
        <property type="gene ID" value="lp_3454"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3454"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2877"/>
    <dbReference type="eggNOG" id="ENOG5030A9J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316763_0_0_9"/>
    <dbReference type="OMA" id="YHLTITS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2917-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="10004" checksum="ACE27E0140920A91" modified="2011-10-19" version="1">MGSFQDLGISQLVKLPLVADTQSGTYHLTITSNSGGNAAVDKIASPLQGVLPQMNGTQQWILFGIGVCGLSLLILLILIWWRNRQTIKEQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG1</accession>
    <name>F9UUG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102188.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3495"/>
    <dbReference type="DNASU" id="1062880"/>
    <dbReference type="EnsemblBacteria" id="CCC80463">
        <property type="protein sequence ID" value="CCC80463"/>
        <property type="gene ID" value="lp_3495"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3495"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2911"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="MESMEDH"/>
    <dbReference type="PhylomeDB" id="F9UUG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2951-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="34952" checksum="AEC623F42CE8A298" modified="2011-10-19" version="1">MNLRHLVFFKELARTQHMAKAAENLGISQPSLSYAIKKLEHELGVPLFEADGRNIKLTSIGGVYLKYVTATLNDLSQGNELVKQLMDPDTGHVKLGFTYTLGQQLVPELLSHFKNQSENQAITFELGQGNSGVLLQALADEKYDIVLASNVDRLGEQLTAHLFDFIPLVQQEIVAVVPNDHPAVQKNPLHVEDLAPYPMILFSQNSGLRPLIDQILSAAHVQPKVAYEVEEDYTMAGFVRYNMGVALMPYLPLLNPERVQIKHLADQPLQHQIYLVVRRSGFITPAVHRFQEFIRSYCWQHYTNQERSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG5</accession>
    <name>F9UUG5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="1">SDH</shortName>
            <ecNumber evidence="1">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroD4</name>
        <name evidence="1" type="synonym">aroE</name>
        <name evidence="3" type="ordered locus">lp_3499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102191.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890981.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3499"/>
    <dbReference type="EnsemblBacteria" id="CCC80467">
        <property type="protein sequence ID" value="CCC80467"/>
        <property type="gene ID" value="lp_3499"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3499"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2915"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_9"/>
    <dbReference type="OMA" id="MPFKESC"/>
    <dbReference type="PhylomeDB" id="F9UUG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2955-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="31525" checksum="C0FC93A7A3494E6B" modified="2011-10-19" version="1">MEKRISGTTGLFTLLGSPVGHSGSPAMYNFSFQEQGLDYAYLAFDVKKAQMPEAIDAIRLFKVRGSNVTMPCKGVAATLVDELSPAAKIVGAINVIVNDNGKLTGHITDGIGFVRNLKENGVDIAGKKLVVIGAGGAATALQVQCALDGAKSLAIFNREDDFYANAENTQKKIKEAKPEVDVNVYHLEDQDKLKAEIEKADILVNATIVGMKPLDGQSLVDPSYLRSDLVVADTVYNPLKTKLIEDAEALGCTVAPGKGMLLWQGDAAYTLFTGKAMPTAEYQAYEARQAAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG8</accession>
    <name>F9UUG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890984.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3502"/>
    <dbReference type="DNASU" id="1062786"/>
    <dbReference type="EnsemblBacteria" id="CCC80470">
        <property type="protein sequence ID" value="CCC80470"/>
        <property type="gene ID" value="lp_3502"/>
    </dbReference>
    <dbReference type="GeneID" id="57026715"/>
    <dbReference type="KEGG" id="lpl:lp_3502"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2918"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="FATDDYP"/>
    <dbReference type="PhylomeDB" id="F9UUG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2958-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="301" mass="33572" checksum="0E8F309992DEBD8F" modified="2011-10-19" version="1">MNLDHLRYFVALSRTENYTQTAKLLHITQPSLTKAIHSLEAELNIDLFQKAGRSVTLTPAGKVFASDVESALLLLDKSVTNIKRFDQQKAPIRIAALRTLSIKWLPDIAQRFLQLSPHAAVQFQFNTDTGLSPDILNGLRNNKYDVAFCSKMDHFSDIEFFPVAEQTMVCITPTTHPLANRSSINLAETLAYPQITFSQRSGLHPIMQKLFNDCGGQPISAYAVEEDQAIAGLVASGFGIAVVPNMSILQTMPVKIIPLSFPTWQRILYMGTLKHRTPQPAVEEFITFVRDQSKTLSVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI5</accession>
    <name>F9UUI5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102201.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3521"/>
    <dbReference type="DNASU" id="1062463"/>
    <dbReference type="EnsemblBacteria" id="CCC80487">
        <property type="protein sequence ID" value="CCC80487"/>
        <property type="gene ID" value="lp_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3521"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2935"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_4_9"/>
    <dbReference type="OMA" id="QDLEHAP"/>
    <dbReference type="PhylomeDB" id="F9UUI5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2975-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="282" mass="30862" checksum="2E846741861DE613" modified="2011-10-19" version="1">MTSVLFTIHNRLENFSKAEQKIGRYILDHTNAVIKMSTAELAAATGVSTATVARFGKTLIPDGGYPALKLRLSAESTVDQTLYDEINPKDSLDAIKSKLALRITHTIDETNRSLDDAALQAASQLIADKASVYVYGLGASNVVATDFEQKFIRIGKAVIHSQDPHLLAVGMTTQRQNVVLLLISNSGEKSESIRLANLAHSINIPVIVLSRNATSTLGKLADIILINDDSEENQTARAAATTSLMAQLYVVDLLYYTFITNDYERHIKQLVASREAIKENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ2</accession>
    <name>F9UUJ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator, BlgB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bglG5</name>
        <name evidence="2" type="ordered locus">lp_3529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891008.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3529"/>
    <dbReference type="EnsemblBacteria" id="CCC80494">
        <property type="protein sequence ID" value="CCC80494"/>
        <property type="gene ID" value="lp_3529"/>
    </dbReference>
    <dbReference type="GeneID" id="57026730"/>
    <dbReference type="KEGG" id="lpl:lp_3529"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2942"/>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078802_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UUJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2982-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="170"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="282" mass="32372" checksum="D4FA3E6485581EEA" modified="2011-10-19" version="1">MKFLKNFNNNAALVVDDQDVEWIVIGNGVGFGKHQGDQIDDQKIQRRFVATLKQNVDIDAFQDLKPQSFVITTKVVHLVEPLLKVSFSDYQYFVLADHIDFALKRANDGIDVDNGTVRWEVKKLFPKEFHAASQAVDLINVTADVILPKSEVVFMTYHFINAGSDGSKLQETIKITKLISGIIDIVQYQYQMHLDPESFNYNRFIAHLRALMVQRVSRSNGTGSELDQSLLQLMQVKYAHAYATVERIDTFLQSKAGWRLEPDDKVYLTLHIWRVTHRQKSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RX6</accession>
    <accession>F9ULM3</accession>
    <name>MNMG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">lp_3681</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891144.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RX6"/>
    <dbReference type="SMR" id="Q88RX6"/>
    <dbReference type="STRING" id="220668.lp_3681"/>
    <dbReference type="PRIDE" id="Q88RX6"/>
    <dbReference type="EnsemblBacteria" id="CCC80630">
        <property type="protein sequence ID" value="CCC80630"/>
        <property type="gene ID" value="lp_3681"/>
    </dbReference>
    <dbReference type="GeneID" id="57026856"/>
    <dbReference type="KEGG" id="lpl:lp_3681"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3074"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_9"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="PhylomeDB" id="Q88RX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3117-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117117" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="636" mass="70736" checksum="5A521AF0EF3AB93A" modified="2003-06-01" version="1">MTEVKQYPGRDYDVIVVGAGHAGSEAALAAARMGNRTLLMTINLDMVAFMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTYVQMRMLNTGKGPAVRALRAQADKHAYHAEMKHTIEREPNLTLRQGIVDGLIVEDGVCKGVITNTGARYSAKSVVLTTGTAARGKIIIGELMYSSGPNNSQPAMKLSGDLERLGFNLERFKTGTPPRVDGNTIDYSVTEEQPGDPEPHHFSFETKDADYIDLKHQLSCWLTYTNETTHKIIRENLDRAPMFTGVIEGVGPRYCPSIEDKIVRFADKKRHQLFLEPEGRNTDEWYVQGLSTSMPEEVQQRILHSIKGLEDAEMMRPGYAIEYDVVAPYQLKATLETKLVKNLYTAGQTNGTSGYEEAAGQGLIAGINAGLRALDRGQFTLKRSDAYIGVMIDDLVTKGTNEPYRLLTSRAEYRLILRHDNADLRLTDKGRELGLIDDERYAAFEAKRQAIKNELDRLGKIRIKPNDEVNAFLRAHNSGELKDGVLAADFLKRPEVQYADLMKFIPAAPEPLERHVIEQVEIQIKYAGYIQKAEERVDRLKKMEAKKIPDRIDYDAIDGLATEAHQKLKKIQPTTIAQASRISGVNPADIAILSVYIQQGRIAKVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88TY1</accession>
    <accession>F9URP5</accession>
    <name>SDHD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable D-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-serine deaminase</fullName>
            <shortName evidence="1">DSD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsdA</name>
        <name type="ordered locus">lp_2776</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine/threonine dehydratase family. DsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101913.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88TY1"/>
    <dbReference type="SMR" id="Q88TY1"/>
    <dbReference type="STRING" id="220668.lp_2776"/>
    <dbReference type="PRIDE" id="Q88TY1"/>
    <dbReference type="EnsemblBacteria" id="CCC79884">
        <property type="protein sequence ID" value="CCC79884"/>
        <property type="gene ID" value="lp_2776"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2776"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2324"/>
    <dbReference type="eggNOG" id="COG3048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035707_0_0_9"/>
    <dbReference type="OMA" id="ESDPNCF"/>
    <dbReference type="PhylomeDB" id="Q88TY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2375-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01030">
        <property type="entry name" value="D_Ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011780">
        <property type="entry name" value="D_Ser_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF9">
        <property type="entry name" value="PTHR48078:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02035">
        <property type="entry name" value="D_Ser_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000185615" description="Probable D-serine dehydratase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01030"/>
        </source>
    </evidence>
    <sequence length="436" mass="47572" checksum="2A74F012004530FD" modified="2003-06-01" version="1">MDTTVMIEEHPQIKELIAKRPIVWQNPDYGKRADLPLTRADIFDAVARWERFAPFLAVAFPETAAMNGIIESPLLPLEQMKPAWEALNHQSLAGQLYLKADSQLPISGSIKSRGGIYEVLKFAEQVAMAHTDLTYMDDYSVLATAKYHELFAQYGVIVASTGNLALSVGIMAATFGFKTTVYMSHDARQWKKDKLRANGVTVEELNTDFSSVIPVARAAAAKDDHTHFVDDEGSRDLFLGYAVAGVRLQHQLKVQGIKMDAAHPVVVYLPAGVGGSPSGVAFGLKMIMGANIYPVFCEPTHVPSVTLGMMTKLNEKIAVQDIGLDGLTAADGLAVSRPSRLAGKVMRTLLLGTATFEDDDLYRYLTKLVDTEDVIVEPSAAAGFTAIAPIMAQFPTLAGKDVTHIVWATGGDMMPESERQLDYELGQKLLTKINNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U22</accession>
    <accession>F9URK3</accession>
    <name>PUR7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="1">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purC</name>
        <name type="ordered locus">lp_2727</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890356.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U22"/>
    <dbReference type="SMR" id="Q88U22"/>
    <dbReference type="STRING" id="220668.lp_2727"/>
    <dbReference type="EnsemblBacteria" id="CCC79842">
        <property type="protein sequence ID" value="CCC79842"/>
        <property type="gene ID" value="lp_2727"/>
    </dbReference>
    <dbReference type="GeneID" id="57026102"/>
    <dbReference type="KEGG" id="lpl:lp_2727"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2282"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_9"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="PhylomeDB" id="Q88U22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2333-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100835" description="Phosphoribosylaminoimidazole-succinocarboxamide synthase">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <sequence length="243" mass="27081" checksum="365D938160E26713" modified="2003-06-01" version="1">MTAAIEKQALLYTGKAKAMYATNDPEILWVEYLDQATALNGKRKVPIDQKGRLNNRIASLIFKDLANHGIANHFIEQPSDYVQLVRRVTMIPLETVVRNAASGSFERKFAVPHLTKFAEPVLEFFYKSDQLDDPFINDSQIHALNVATPAIVAEIKRQALQVNQRLTAIFAAMGVQLVDFKIEFGLTTTGKVLLADEISPDSCRLVDLKTGASLDKDVFRKDLGDLTSVYQEVLTRLATVEEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-03" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UZ4</accession>
    <accession>F9UQL2</accession>
    <name>RECA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">lp_2301</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890015.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UZ4"/>
    <dbReference type="SMR" id="Q88UZ4"/>
    <dbReference type="STRING" id="220668.lp_2301"/>
    <dbReference type="PRIDE" id="Q88UZ4"/>
    <dbReference type="EnsemblBacteria" id="CCC79501">
        <property type="protein sequence ID" value="CCC79501"/>
        <property type="gene ID" value="lp_2301"/>
    </dbReference>
    <dbReference type="GeneID" id="57025837"/>
    <dbReference type="KEGG" id="lpl:lp_2301"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1945"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_9"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="PhylomeDB" id="Q88UZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1985-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122736" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="380" mass="40652" checksum="E7B6ABF05BA5B0B8" modified="2003-06-01" version="1">MADARKAALDTALKKIEKNFGKGAIMRMGDAAQTTISTISSGSLALDDALGVGGYPRGRIVEIYGPESSGKTTVALHAVAEVQKQGGTAAYIDAENALDPVYAEHLGVNIDDLLLSQPDTGEQGLEIADALVSSGAVDILVVDSVAALVPRAEIEGEMGDAHVGLQARLMSQALRKLSGTLNKTKTIALFINQIREKVGVMFGNPETTPGGRALKFYATIRLEVRRAEQIKEGTNIIGNRVRIKVVKNKVAPPFKRAEVDIMYGQGISQTGEIVDMAAEKDIVKKSGSWYSYGDDRIGQGRENAKKYLDEHPDVMTEIRQKVRDAYGMDATGEETSETDDQAKEAKDKGTAKNGSKGQSKSTKATPAETALDLGDQPTEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VK3</accession>
    <accession>F9UQ01</accession>
    <name>RIMP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">lp_2044</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640728.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889804.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VK3"/>
    <dbReference type="SMR" id="Q88VK3"/>
    <dbReference type="STRING" id="220668.lp_2044"/>
    <dbReference type="EnsemblBacteria" id="CCC79290">
        <property type="protein sequence ID" value="CCC79290"/>
        <property type="gene ID" value="lp_2044"/>
    </dbReference>
    <dbReference type="GeneID" id="57025596"/>
    <dbReference type="KEGG" id="lpl:lp_2044"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1729"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_0_9"/>
    <dbReference type="OMA" id="YIHVSLY"/>
    <dbReference type="PhylomeDB" id="Q88VK3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1751-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000181882" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="158" mass="17730" checksum="6FBC3B91D527304A" modified="2003-06-01" version="1">MSSNVVETIQPVAAAIVSAHQFELVDLEFVREGQSWYLRLYIDKPGGINIEECAMVSDELSEKLDAMEPDPIPQAYFLEVSSPGAERPLKKEADFQNAIGKYVHVGLYQKLDGKKIFEGDLTAVTPTTLTIDYLDKTRHKTVTINREQISQARLAVKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VQ3</accession>
    <accession>F9UPU9</accession>
    <name>DTD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">lp_1986</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889752.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VQ3"/>
    <dbReference type="SMR" id="Q88VQ3"/>
    <dbReference type="STRING" id="220668.lp_1986"/>
    <dbReference type="EnsemblBacteria" id="CCC79238">
        <property type="protein sequence ID" value="CCC79238"/>
        <property type="gene ID" value="lp_1986"/>
    </dbReference>
    <dbReference type="GeneID" id="57025563"/>
    <dbReference type="KEGG" id="lpl:lp_1986"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1678"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_9"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="PhylomeDB" id="Q88VQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1702-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000164551" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="148" mass="16007" checksum="7BF7CF86B0798577" modified="2003-06-01" version="1">MRVIVQRSQQAQVSIDGKVRGTIDHGFVLLVGFQDGDGQAELDYIAHKILNLRVFSDADGKMNLNIQQVGGAILSISQFTLYAETRHGNRPSFTAAGNPELASKLYDTFNQQLAASGVTVATGEFGADMQVSLVNDGPVTICYDTDQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ3</accession>
    <accession>F9UP10</accession>
    <name>RIMM_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">lp_1638</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640383.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ3"/>
    <dbReference type="SMR" id="Q88WJ3"/>
    <dbReference type="STRING" id="220668.lp_1638"/>
    <dbReference type="EnsemblBacteria" id="CCC78949">
        <property type="protein sequence ID" value="CCC78949"/>
        <property type="gene ID" value="lp_1638"/>
    </dbReference>
    <dbReference type="GeneID" id="57025220"/>
    <dbReference type="GeneID" id="66449519"/>
    <dbReference type="KEGG" id="lpl:lp_1638"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1385"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_1_9"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="PhylomeDB" id="Q88WJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1412-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000163305" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="98"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <sequence length="174" mass="19323" checksum="78A6BFB55234F4A0" modified="2003-06-01" version="1">MDYYRVGTLVNTHGIRGEVKVVVVTDFPEERFKVGQQLSLFKTPDETTGGITVKIAKAREQKGLYFLTFEGLDNINDVERYKGWTIKVPAEALHALPAGEYYYHQIVGLQVVTTADEPLGTIKEILSPGANDVWVVKRDHGQSDVLLPKIPQVIKDVDLDAGVVTVELMEGLID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WT5</accession>
    <accession>F9UNR5</accession>
    <name>NADD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="1">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadD</name>
        <name type="ordered locus">lp_1530</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640290.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889368.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WT5"/>
    <dbReference type="SMR" id="Q88WT5"/>
    <dbReference type="STRING" id="220668.lp_1530"/>
    <dbReference type="EnsemblBacteria" id="CCC78854">
        <property type="protein sequence ID" value="CCC78854"/>
        <property type="gene ID" value="lp_1530"/>
    </dbReference>
    <dbReference type="GeneID" id="57025125"/>
    <dbReference type="GeneID" id="66449421"/>
    <dbReference type="KEGG" id="lpl:lp_1530"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1288"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_1_9"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="PhylomeDB" id="Q88WT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1315-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000181418" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <sequence length="211" mass="24027" checksum="97D6BBF0EEC7410C" modified="2003-06-01" version="1">MQTVNQTATKVLTETVTAIPHRRVGILGGTFNPPHLGHLIMAQQVGDQLGLDEVRFMPDAQPPHVDEKKTIAVEDRANMVQEAIVDNPLFRLETAEIERGGKSYTYETMKFLKAKHPDTQYYFIIGGDMVDYLHTWYHIDELVKLVTFVGIKRTGYPTTSQYPVIWVDAPLIDISSTQIRQKISHGHSVRYLVPEAVAAYIKEHHLYEQND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WU7</accession>
    <accession>F9UNQ3</accession>
    <name>RL35_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">lp_1516</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638526.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889356.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WU7"/>
    <dbReference type="SMR" id="Q88WU7"/>
    <dbReference type="STRING" id="220668.lp_1516"/>
    <dbReference type="EnsemblBacteria" id="CCC78842">
        <property type="protein sequence ID" value="CCC78842"/>
        <property type="gene ID" value="lp_1516"/>
    </dbReference>
    <dbReference type="GeneID" id="49393790"/>
    <dbReference type="GeneID" id="57025113"/>
    <dbReference type="GeneID" id="66449402"/>
    <dbReference type="KEGG" id="lpl:lp_1516"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1276"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_3_1_9"/>
    <dbReference type="OMA" id="GTSMMNH"/>
    <dbReference type="PhylomeDB" id="Q88WU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1303-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000177372" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <sequence length="64" mass="7419" checksum="0D707745C7CAA9FA" modified="2003-06-01" version="1">MPKQKTNRAAAKRFKVTAKGKIKSANAFTSHRFHGKTKKQRRQLRGTAIIEKPMVKTYHKLLQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XT4</accession>
    <accession>F9UMQ8</accession>
    <name>CITG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase</fullName>
            <shortName evidence="1">2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase</shortName>
            <ecNumber evidence="1">2.4.2.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">citG</name>
        <name type="ordered locus">lp_1093</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine</text>
            <dbReference type="Rhea" id="RHEA:15117"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61378"/>
            <dbReference type="EC" id="2.4.2.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CitG/MdcB family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.52" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889011.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XT4"/>
    <dbReference type="STRING" id="220668.lp_1093"/>
    <dbReference type="EnsemblBacteria" id="CCC78497">
        <property type="protein sequence ID" value="CCC78497"/>
        <property type="gene ID" value="lp_1093"/>
    </dbReference>
    <dbReference type="GeneID" id="66448997"/>
    <dbReference type="KEGG" id="lpl:lp_1093"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.926"/>
    <dbReference type="eggNOG" id="COG1767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056179_1_0_9"/>
    <dbReference type="OMA" id="QSWQRPA"/>
    <dbReference type="PhylomeDB" id="Q88XT4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-940-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00397">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017551">
        <property type="entry name" value="TriPribosyl-deP-CoA_syn_CitG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30201">
        <property type="entry name" value="PTHR30201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03125">
        <property type="entry name" value="citrate_citG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000214675" description="Probable 2-(5'-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00397"/>
        </source>
    </evidence>
    <sequence length="280" mass="30279" checksum="AAB7B18D994602CC" modified="2003-06-01" version="1">MDTKIIVNHALRALLYEVTVNPKPGLVDPLSAGPHPDMNAFMFIDSALSLAPYFNACAAAGVAYTAVDLTGLFKQIRGIGVQAEQTMFAATKGVNTHKGAVFSLGVLVTAAAYQLQHPDVDLATIVRTMLAGLTANDFNDLNTKDPTTLTAGERQYLTYGIKGIRGEAEAGYPTVMQVALPALRRSRGTINQRLLDTLMAIVQATVDTNLVKRAHDPHVIDWVHDQAHRYFDLGGSRSEAGMAFLRELNQIFVDHNYSLGGSADLLILTIFIGLQTDILA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XU9</accession>
    <accession>F9UMP3</accession>
    <name>TRUA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">lp_1076</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XU9"/>
    <dbReference type="SMR" id="Q88XU9"/>
    <dbReference type="STRING" id="220668.lp_1076"/>
    <dbReference type="PRIDE" id="Q88XU9"/>
    <dbReference type="EnsemblBacteria" id="CCC78482">
        <property type="protein sequence ID" value="CCC78482"/>
        <property type="gene ID" value="lp_1076"/>
    </dbReference>
    <dbReference type="GeneID" id="57024728"/>
    <dbReference type="KEGG" id="lpl:lp_1076"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.911"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_9"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="PhylomeDB" id="Q88XU9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-925-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000057396" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="262" mass="29805" checksum="F01BC895E315D4C8" modified="2003-06-01" version="1">MTTRYKVVLAYDGTNFAGFQRQPHQRTVEQVVTKAVNKMAKDPVEPIVIYGAGRTDAGVHAFGQTLHFDLPYEINPEGVRRGLNSMLPMDTIVKAVSIVPNDFHARYDTVGKRYWYRAYQNEFVDPFKRHYTGHFKFAADIDRIQQAIGDLEGRHDFSTFVASGSQAHDHVREIYSAKAWALPDEREIQFEFCGSGFLYNQVRIMVAVLMEIGQGRRAVDCIPALLAAKDREQARGTAPAAGLYMKKVYYEQNELQADLIKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW5</accession>
    <accession>F9UMM6</accession>
    <name>KAD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">lp_1058</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW5"/>
    <dbReference type="SMR" id="Q88XW5"/>
    <dbReference type="STRING" id="220668.lp_1058"/>
    <dbReference type="EnsemblBacteria" id="CCC78465">
        <property type="protein sequence ID" value="CCC78465"/>
        <property type="gene ID" value="lp_1058"/>
    </dbReference>
    <dbReference type="GeneID" id="57024712"/>
    <dbReference type="KEGG" id="lpl:lp_1058"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.892"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_9"/>
    <dbReference type="PhylomeDB" id="Q88XW5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-908-MON"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000158783" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="219" mass="24462" checksum="D0A417F00E4F9A05" modified="2011-11-16" version="2">MSTMNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVPDEVTNGIVRDRLAEADTKNGFLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVLVERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQRDDDKPATVKNRLDVNIKLNTPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX1</accession>
    <accession>F9UMM0</accession>
    <name>RL6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">lp_1051</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX1"/>
    <dbReference type="SMR" id="Q88XX1"/>
    <dbReference type="STRING" id="220668.lp_1051"/>
    <dbReference type="PRIDE" id="Q88XX1"/>
    <dbReference type="EnsemblBacteria" id="CCC78459">
        <property type="protein sequence ID" value="CCC78459"/>
        <property type="gene ID" value="lp_1051"/>
    </dbReference>
    <dbReference type="GeneID" id="57024706"/>
    <dbReference type="GeneID" id="66448962"/>
    <dbReference type="KEGG" id="lpl:lp_1051"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.886"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_9"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="PhylomeDB" id="Q88XX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-902-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000260881" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="178" mass="19350" checksum="82D7C0BBE90B4A0F" modified="2003-06-01" version="1">MSRIGYKVIELPAGVEVSQAGEVVTVKGPKGTLTRNIASDITMTVEGNEVKFTRPSDDYKMKALHGTTRANVNNMVEGVTKGFTKNLQLVGVGYRAQLQGKKLVLSVGYSHPVEFATPENLTVEVPDNTHINISGIGKQAVGDFAAEVRAVRSPEPYKGKGIRYVDEYVRRKEGKTGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX4</accession>
    <accession>F9UML7</accession>
    <name>RL5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">lp_1047</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888970.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX4"/>
    <dbReference type="SMR" id="Q88XX4"/>
    <dbReference type="STRING" id="220668.lp_1047"/>
    <dbReference type="EnsemblBacteria" id="CCC78456">
        <property type="protein sequence ID" value="CCC78456"/>
        <property type="gene ID" value="lp_1047"/>
    </dbReference>
    <dbReference type="GeneID" id="49393329"/>
    <dbReference type="GeneID" id="57024703"/>
    <dbReference type="KEGG" id="lpl:lp_1047"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.883"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_9"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="PhylomeDB" id="Q88XX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-899-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124939" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="180" mass="20238" checksum="F893BDD6C668EC0B" modified="2003-06-01" version="1">MENRLKAQYEKEIVPALVDKFNYTSVMQVPKLAKIVLNMGVGDAVTNAKNLDEAVEELTLISGQKPLVTRAKKSIAGFRLREGMAIGAKVDLRGERMYDFLDKLINVSLPRVRDFHGVSTRSFDGRGNYTLGVREQLIFPEINYDNVNRVRGLDIVIVTTADSDEESRELLTQFGMPFAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-29" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY8</accession>
    <accession>F9UMK3</accession>
    <name>EFG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G</fullName>
            <shortName evidence="1">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA</name>
        <name type="ordered locus">lp_1027</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645499.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY8"/>
    <dbReference type="SMR" id="Q88XY8"/>
    <dbReference type="STRING" id="220668.lp_1027"/>
    <dbReference type="EnsemblBacteria" id="CCC78442">
        <property type="protein sequence ID" value="CCC78442"/>
        <property type="gene ID" value="lp_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1027"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.868"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_9"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="PhylomeDB" id="Q88XY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-885-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091139" description="Elongation factor G">
        <location>
            <begin position="1"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="698" mass="77013" checksum="E893E1D721A21993" modified="2003-06-01" version="1">MANTREFSLDKTRNIGIMAHIDAGKTTTTERILYYTGKIHKIGETHDGASQMDWMAQEQERGITITSAATTAQWKNHRINIIDTPGHVDFTVEVERSLRVLDGAIAVLDAQSGVEPQTETVWRQASTYNVPRIVFVNKMDKIGADFKYSVSTIHDRLQANAHAIQLPIGAEDNFEGVIDLIEMKADLYDEDQLGTEWDTVDVPDEYKEEAQAARDDLIEALADIDDGIMEKYLGGEEISKEEIKAAIRKGTLALEFFPVLAGSAFKNKGVQMLMDAVVDYLPSPLDVKPYKATDPETEEEVDLIAGDDKPFAALAFKVATDPFVGRLTFIRVYQGTLESGSYVLNATKDKRERVGRLLQMHSNQRKEIPEVFSGDIAAAIGLKNTTTGDSLTSIEHPYHLESMEFPDPVIQVAVEPKTKADQDKMNVALQKLSEEDPTFKAETNPETGETLIAGMGELHLDIIVDRMRREFNVEATVGAPQVSYRETFTKSTQVQGKFVHQSGGKGQYGDVWVEFTPNEEGKGFEFEDAIVGGVVPREYIPSVEQGLKEAMANGVLAGYPLVDVKAKLYDGSYHDVDSSEAAFKIAASLALRNAVKTAGPVILEPIMKVDIVAPEDYLGDVMGHVTARRGNIEGMEERGNAQEVHAYVPLAEMFGYATTLRSATQGRGTFTMTFDHYEKVPKSVQEDIIKKNGGTPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YN0</accession>
    <accession>F9ULV4</accession>
    <name>TSAD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">lp_0721</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YN0"/>
    <dbReference type="SMR" id="Q88YN0"/>
    <dbReference type="STRING" id="220668.lp_0721"/>
    <dbReference type="EnsemblBacteria" id="CCC78193">
        <property type="protein sequence ID" value="CCC78193"/>
        <property type="gene ID" value="lp_0721"/>
    </dbReference>
    <dbReference type="GeneID" id="57024428"/>
    <dbReference type="KEGG" id="lpl:lp_0721"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.606"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_9"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="PhylomeDB" id="Q88YN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-628-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303396" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="348" mass="37564" checksum="A76D6260948672D8" modified="2003-06-01" version="1">MGTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIEQITICIEAALQEAHVTYADLDAVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMAGHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEIIGETRDDAAGEAYDKIGRVLGVPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKNDLAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELILAPLKLCGDNGAMIGAAGYVQYQHHQFGDATLNADPSLEFDWMPGMLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q890D7</accession>
    <accession>F9USR9</accession>
    <name>Y089_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein lp_0089</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0089</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100877.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888164.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890D7"/>
    <dbReference type="SMR" id="Q890D7"/>
    <dbReference type="EnsemblBacteria" id="CCC77650">
        <property type="protein sequence ID" value="CCC77650"/>
        <property type="gene ID" value="lp_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0089"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.73"/>
    <dbReference type="eggNOG" id="COG3022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061989_1_0_9"/>
    <dbReference type="OMA" id="WKNGQYK"/>
    <dbReference type="PhylomeDB" id="Q890D7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-72-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000203988" description="UPF0246 protein lp_0089">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <sequence length="248" mass="28577" checksum="71D2DBAC643E0DEA" modified="2003-06-16" version="1">MKIIIAPAKKMIIDQDAFPALTEPIYLDQTQQLLAQLQHLTYPEAKTLWHCSDKLAQPNYDWLQKIDLTRNLTPAILSYSGIQYRYMAPDVFTQPALDYIQANLRILSGFYGILRPFDGIVPYRLEMQARLAVGQAKNLYAFWGDRLYQALTPRPEPIINLASQEYAKTIAPYLAPHQSMIDIVFASFIDGKLKTKATLARMARGAMVRFLAEHQIDDVTAIRTFDHPDYQFDEKRSTANRFVFIYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW5</accession>
    <name>F9UKW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0483"/>
    <dbReference type="EnsemblBacteria" id="CCC77980">
        <property type="protein sequence ID" value="CCC77980"/>
        <property type="gene ID" value="lp_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0483"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.397"/>
    <dbReference type="HOGENOM" id="CLU_195720_0_0_9"/>
    <dbReference type="OMA" id="HQIVECP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-401-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="56" mass="6091" checksum="BAB74FD633D77666" modified="2011-10-19" version="1">MSAKCPSCGASVELEKDVLTGEIVECEECGEELEVKNEDGTFLLNLAPDVEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL25</accession>
    <name>F9UL25_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640888.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0552"/>
    <dbReference type="EnsemblBacteria" id="CCC78040">
        <property type="protein sequence ID" value="CCC78040"/>
        <property type="gene ID" value="lp_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="57024333"/>
    <dbReference type="KEGG" id="lpl:lp_0552"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.459"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077420_1_1_9"/>
    <dbReference type="OMA" id="LGYRREW"/>
    <dbReference type="PhylomeDB" id="F9UL25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-468-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022302">
        <property type="entry name" value="Phosphoesterase_putative"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03729">
        <property type="entry name" value="acc_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="32600" checksum="ECAED13E35F70897" modified="2011-10-19" version="1">MEGLTIVRIAFSSDNHFDVNRVDATAMMRSQATYLLQNGVQIYLIAGDLFNDFQRSQQFVVDLQALLGAQTRVYWIAGNHDMVHGISFDELETGHFDGYLHNRYIDISGTDWRVIGHNGWYDYQYAAQVPDTTAADFLHWKNAFWIDRAIKQPMSDQERTDLMLNQVKAQLNLAAVDHKQVIFMTHFVPRIDYLRFSDDNRFWNMANALMGTPRLGQLLEQFNVAHVLFGHLHVHPQPRVFGQTTYYDQAVGYGLKRINEWQANNFMAEWYQDTQILDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL63</accession>
    <name>F9UL63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional attenuator, cell envelope-related, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101070.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888592.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0593"/>
    <dbReference type="DNASU" id="1061550"/>
    <dbReference type="EnsemblBacteria" id="CCC78078">
        <property type="protein sequence ID" value="CCC78078"/>
        <property type="gene ID" value="lp_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0593"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.497"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_2_0_9"/>
    <dbReference type="OMA" id="GYIMINM"/>
    <dbReference type="PhylomeDB" id="F9UL63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-509-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="111"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="43601" checksum="47AFADA54BA8E024" modified="2011-10-19" version="1">MSENNNDNEMGPRQRRYREQQQRNPHLKPHKKRPWLITLLIVVVLLIVTGGWWGYKTWNAAKDTMNTTYQSTGSTKLRNVDAVIKKGKPFSILLLGTDTGALGRGKDFSARTDTMIVATINPKKESMTLTSIPRDTQVMIDGQSQKINAAYTIGGASGAVKSVEKLLDVPIDFYVLLNMGGLKQIINAMGGVTVTPKLTFKYGNANVKKGVKIKLNGAAALDYSRMRYDDPQGDYGRQKRQQQVIMAMVSQSNSLGSIANIEKITKKLAKNMRTDLTWNDMVALDTKYKNASHHAKSYTVQGTDATIDGLSYQVASSSERYKNSKRIRKALGLSNSNLTESVFSETASITTGSSSSSSSSSSTTTSSDTTTYGTSTTQDTTTQDQTTTQDQTTTNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD5</accession>
    <name>F9ULD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator accesory gene regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lamA</name>
        <name evidence="6" type="ordered locus">lp_3580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891056.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3580"/>
    <dbReference type="EnsemblBacteria" id="CCC80542">
        <property type="protein sequence ID" value="CCC80542"/>
        <property type="gene ID" value="lp_3580"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3580"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2987"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="ISVYICE"/>
    <dbReference type="PhylomeDB" id="F9ULD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3029-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="28626" checksum="CDF2FEB7F7F1BD75" modified="2011-10-19" version="1">MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELLDKVNAQQPQKAIYVLDIALNSDVNGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIAETVRSINVKSIIFFESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLTMTNGEKVLCSAQANRYLAKWLAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF2</accession>
    <name>F9ULF2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3598"/>
    <dbReference type="EnsemblBacteria" id="CCC80559">
        <property type="protein sequence ID" value="CCC80559"/>
        <property type="gene ID" value="lp_3598"/>
    </dbReference>
    <dbReference type="GeneID" id="66451032"/>
    <dbReference type="KEGG" id="lpl:lp_3598"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3003"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_0_9"/>
    <dbReference type="OMA" id="FDNDVTR"/>
    <dbReference type="PhylomeDB" id="F9ULF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3046-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="259" mass="29167" checksum="1283417AAD7533C4" modified="2011-10-19" version="1">MVSRDDRVLHILKILNKHPRISVKRLIELTGESVSTMRRDLIVLEQSGKVKRTFGMVSLLENTNIEFASPFRYRTHVEEKKVICRLLARRVIKDNQALFIDPSTTTAYLPNYLSERQNVKVITDNLQFAIAANQMTNLNLFLTGGSLRPNSNSLLGNHTIQDIAMFRPQLAIVSCSTLDNTGAYIADMDQADVKIAMMKSARESILVADHTKFQSVNSDYIRLASFPAWSTIVTDRAPKDQFLKHMAALGVKVIYPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL3</accession>
    <name>F9ULL3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatic compound hydratase/decarboxylase</fullName>
            <ecNumber evidence="1">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891134.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3666"/>
    <dbReference type="EnsemblBacteria" id="CCC80620">
        <property type="protein sequence ID" value="CCC80620"/>
        <property type="gene ID" value="lp_3666"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3666"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3064"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_0_9"/>
    <dbReference type="OMA" id="IQRAWVA"/>
    <dbReference type="PhylomeDB" id="F9ULL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3107-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="266" mass="28429" checksum="FB6958EC9F04EFBE" modified="2011-10-19" version="1">MTTTTTETETQVAQQLFTAYQTQHALTMADFTSSVVDEDAAYRVQAALTALKQQPVGGYKVSLTSAETQKMFDAHTPLYGVQVADHFLAAPTTVRRGQLMDPLVEVELVFKAKEDLSTTDSLTDLWQKTTVAPGLELPDSRFADWFPDLPKNLVVADAAVGGLVVYGTERETAELFASADAVATSKCTLVHDGGTVKTGQASEVLGNPLESLKWLVGKLAEQGKTLTAGQRVSSGTFVLPPHLTAGHWQADFDAGLGQVALDVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL7</accession>
    <name>F9ULL7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepC2</name>
        <name evidence="3" type="ordered locus">lp_3673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102285.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3673"/>
    <dbReference type="EnsemblBacteria" id="CCC80624">
        <property type="protein sequence ID" value="CCC80624"/>
        <property type="gene ID" value="lp_3673"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3673"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3068"/>
    <dbReference type="eggNOG" id="COG3579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_9"/>
    <dbReference type="OMA" id="GEPHRYN"/>
    <dbReference type="PhylomeDB" id="F9ULL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3111-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="438" mass="49998" checksum="8975117EFB635EFE" modified="2011-10-19" version="1">MATELTPDALAALRTTHAQDRMAPVLTRAITKNGIEAASFDNQAASRLARTFSVELPTGKVSNQKHSGRCWEFSLLNTLRHKFATRYHVKDFELSQNYLFFWDKIERANIFYRNVEQTARQPIDDRLVQFLFANPGEDGGQWAMAASLVQKYGVVPASVMPESFNTDNTTAFQASLSRQLRKDGLKLRQLVMDGASEAELQSLEKSMLQTVYRMTAYSFGEPPTSFDLEYRDDEQHYHRTANLTPQQFYQDYFETDLDDYVVVTNSPDKPFNRLYSLPDEDNVIGGKPIEFLNLDMGVLTDVAVQQLQAGETVWFGNDVLRQMDRKTGYLDAHLFETGKLFGTNDHLTKAQRLLTGEGEVSHAMTLTGVDLVADTPTKWKVENSWGEQVGDQGYFVMSQDWFNEYVYEVVVHKHFLAPEFQALLNERAQRLPAWDPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL9</accession>
    <name>F9ULL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891140.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3676"/>
    <dbReference type="EnsemblBacteria" id="CCC80626">
        <property type="protein sequence ID" value="CCC80626"/>
        <property type="gene ID" value="lp_3676"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3676"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3071"/>
    <dbReference type="eggNOG" id="ENOG5030B1D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541624_0_0_9"/>
    <dbReference type="OMA" id="WPITHIA"/>
    <dbReference type="PhylomeDB" id="F9ULL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3113-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388810" evidence="1">
        <location>
            <begin position="28"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="512" mass="56801" checksum="A5457A981C15EB54" modified="2011-10-19" version="1">MRRLLTGTLVVGGLLLVVCLMAVNGQAKVVDEPTSAMQDITTNFEQRTIGRVPWPITHIAANYVRDDHMTHKTSRVKITLGKGVVHSPNGKGLYNLWDLVLNRQGKEYGATFLAYNINNRVWRPHRTDTIKTHGIKAGQPVWIGNKSSTNASSNPIRTLPAYMVTKQYCQMVSQIKLSPHITGFEANKRIITGTGTQGGDLITAKFGNQIKKTRVDHEGRWQMKCFSGNGHLMVTETNAYDDIPGHTETVINNGTPRTDATIKLNLFLTNGHTFSTAKGRKVLVTGMILGTDQNDFDRDVVLKNNALTIHFAHADGTPIANYKANGSVNEPDKAGYFHLKLPTESLKQGPNDVKVWVSDQHGQRSNIDTLTVNVNSGLMFGQINAQMRFRSNTIPQSERLLSPTNQWQIEVHDTRSVASKWYVYATATKMKSAQHSLIGDLVYIDAAGQKHVMTNQETLVGHGTHTNPNQQTTNIAATWQARQGIFLDVQPELYAGSYHGKINWSLQDTPQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULM5</accession>
    <name>KHPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 5">RNA-binding protein EloR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Single stranded DNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpB</name>
        <name evidence="2 5" type="synonym">eloR</name>
        <name type="ordered locus">lp_3683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="MSphere" volume="4" first="0" last="0">
            <title>CRISPR Interference for Rapid Knockdown of Essential Cell Cycle Genes in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Myrbraaten I.S."/>
                <person name="Wiull K."/>
                <person name="Salehian Z."/>
                <person name="Haavarstein L.S."/>
                <person name="Straume D."/>
                <person name="Mathiesen G."/>
                <person name="Kjos M."/>
            </authorList>
            <dbReference type="PubMed" id="30894429"/>
            <dbReference type="DOI" id="10.1128/msphere.00007-19"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE SUBUNIT</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Necessary for correct cell elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Forms a complex with KhpA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has an N-terminal Jag-N domain, a linker with a phosphorylated Thr, and 2 RNA-binding domains (KH and R3H).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Cell length is reduced.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102290.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3683"/>
    <dbReference type="EnsemblBacteria" id="CCC80632">
        <property type="protein sequence ID" value="CCC80632"/>
        <property type="gene ID" value="lp_3683"/>
    </dbReference>
    <dbReference type="GeneID" id="57026858"/>
    <dbReference type="KEGG" id="lpl:lp_3683"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3076"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_0_9"/>
    <dbReference type="OMA" id="INQKHAP"/>
    <dbReference type="PhylomeDB" id="F9ULM5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3119-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00867">
        <property type="entry name" value="KhpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000454542" description="RNA-binding protein KhpB">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="256"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Jag_N domain" evidence="2">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8CY87"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="322" mass="34181" checksum="38EA7C52306580DA" modified="2011-10-19" version="1">MTVFEGNTVAAAIAAGLKQLHRTRDQVEVEVIAEAKKGFLGLGKHPAQVRLTVVPASAAPATTPTSATATAQQSVATESTTAPTMPRPTVQTPKSTPTRQAKTSQATTSAAKPATSKAKAVAKPASMAVTTGPVIADTDQSKPATTSKTKSVAADQSQTPRTPAEIAARQAANETAVRALCDYLLAVVKELGVTADLDVDFGNRYATLNFDTTKQGLLIGKHGRTINALQDLAQVYMNHHGASHVNVVLDVDDYRERRAATLKRLAESTAREVIATGKQVFLDPMPSFERKLIHAELANNHHVTTFSEGRDPHRAVVVAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULM7</accession>
    <name>F9ULM7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102292.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="RIAYQAQ"/>
    <dbReference type="PhylomeDB" id="F9ULM7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3121-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
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        <property type="entry name" value="SBP_5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388967" evidence="3">
        <location>
            <begin position="36"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="89"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="545" mass="60539" checksum="0967C2322AC39F4A" modified="2011-10-19" version="1">MQAKYTYSIIGVVSALLLTGCLGAVSNSSKTTSTADQNRTLGITIPGEPMTTDPTTSIETNGGAVITQTGEGIYRKNANNKIVAGVVEKKVKPTENKTRYTFTIRKNARWQNGTKITSQDFVTALRRQANPTTKSQNLDAISYIKNFDAVNKGKMAVNKLGVTAINKRTFSIKLSKPVPYMNYEFTSFYPLNTEAVQKYGSKLGSNSATTVANGAYVIKGWKGSNDSWYYVKNKYYWNAKNVKIKRIKVTVTKDDNTAQNLFNAGTVQVTNISGQYVKNNANNSQMTVTKTGRNNYIYFNSKKSVTANENFRHALSLVINQKTLAKDVLQDGSQAATNIVPKNYASDPTTGEDFVKEVGNLSPTNIKQAKQYWQKAQKELGKQNVTLNFLCDDTDTEKKLAEYVQGVAEKYLKGVTIKIVAVPHATHVSRDFTGNFDLVTVGWGPDYPDAQNFLDGMQSSNSINFTQWKDAKYDALMAKVSNTAKYTAAQRWTYEKQADRRLMKLDAVIPTYQASSAFLVSKDVGGLQWDEFSGTSSQLQYAYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
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    <name>F9ULQ6_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Prophage P1 protein 45, head-tail joining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0668"/>
    <dbReference type="EnsemblBacteria" id="CCC78145">
        <property type="protein sequence ID" value="CCC78145"/>
        <property type="gene ID" value="lp_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0668"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.560"/>
    <dbReference type="eggNOG" id="ENOG5030A3G">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1616942_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-579-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20123" checksum="F5C8F1F86B2CF67C" modified="2011-10-19" version="1">MANNYDKIPAVKFSIDVDYFNQLFETARRLAHNGMPEAIEEANKEYQRAVALSKAFIKNAGAREKEAAQGLERTQVGHGKSGYEPTGTLQGSLEIKISDDGKSVSVMPMATVADQKRALAAIAGSGSKKPITSQDGVDYYGVYVEYGTYKMAAEPFMKPTGEKIATRLENDFDRIMRLAVLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR2</accession>
    <name>F9ULR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101124.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0674"/>
    <dbReference type="DNASU" id="1061977"/>
    <dbReference type="EnsemblBacteria" id="CCC78151">
        <property type="protein sequence ID" value="CCC78151"/>
        <property type="gene ID" value="lp_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="57025306"/>
    <dbReference type="KEGG" id="lpl:lp_0674"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.566"/>
    <dbReference type="eggNOG" id="COG4722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095671_0_0_9"/>
    <dbReference type="OMA" id="AREITYE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-585-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="28758" checksum="FCAB521F35DE4DE3" modified="2011-10-19" version="1">MVMDHDIYFGYQRPRPTEYVQFANFDSRQLNLYLAGRIANNPPTKEVTESIGYMDGIIDFSDILGRRIFDNRTIEYQFKALNINYHDRKLLEQKCKRLLLIPMRQPIYDSHDLPFYWFGKASSVTANDDHVNNVLEITVQFNVSPYALRKGQFDDIWDNFSLETGYAQFTKYSVKGTKKISLYNDSDLKSRLKVICQNDMTINGKYKYTKNYQDNPNFRLEPGINDLTVNGNGDIEFQWESEVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR5</accession>
    <name>F9ULR5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 54, minor head protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101127.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888668.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0677"/>
    <dbReference type="EnsemblBacteria" id="CCC78154">
        <property type="protein sequence ID" value="CCC78154"/>
        <property type="gene ID" value="lp_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="57025309"/>
    <dbReference type="KEGG" id="lpl:lp_0677"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.569"/>
    <dbReference type="eggNOG" id="ENOG5030IEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341849_0_0_9"/>
    <dbReference type="OMA" id="FTINVMD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-588-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018913">
        <property type="entry name" value="BppU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10651">
        <property type="entry name" value="BppU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BppU_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="204" mass="22763" checksum="36F0B00F1C74FF2D" modified="2011-10-19" version="1">MANQELVYDITKQPNLQPAQQAIYARVGDGGLKTVTVKLNANNYPYDLTGKHVNFEGVKADSTRIIDTSGGIVLDPQGGIFRYVFPAQTFTARGRFQQAFFKVMLGDKVDTTIDVVVDVSPNLVEFGINSESYLSEYEQLISELKDKQQTFLTDLGQKVDLSKTQLQNISDRLDNIKTQLATNDVVSKTEFNTKLKNVVFIKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW3</accession>
    <name>F9ULW3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101145.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0734"/>
    <dbReference type="EnsemblBacteria" id="CCC78202">
        <property type="protein sequence ID" value="CCC78202"/>
        <property type="gene ID" value="lp_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0734"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.618"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_2_1_9"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="PhylomeDB" id="F9ULW3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-637-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="23713" checksum="6C7B7F3B806BFD26" modified="2011-10-19" version="1">MTKPYYTITQDTVFEQTIKKSRFIAHLYRISDEVDAQAKIAAVRADNPKANHNCFAYMLGDDDHIQRMSDDGEPVGTAGSPILEVLKTNELHDVLAVVTRYFGGIKLGAGGLIRAYNGTPAQAIEVSGKVQRILQARIAITLDYRNVDALTYYLQQNKLTTLNTDYGVQVTQIIAVTQSEIATIQQDITNLLSGQVTFSEQGEQFTEIPVTTPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX1</accession>
    <name>F9ULX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two-component system response regulator,phosphate transport regulon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp3</name>
        <name evidence="8" type="ordered locus">lp_0743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640997.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888724.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0743"/>
    <dbReference type="EnsemblBacteria" id="CCC78210">
        <property type="protein sequence ID" value="CCC78210"/>
        <property type="gene ID" value="lp_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="57024444"/>
    <dbReference type="KEGG" id="lpl:lp_0743"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.625"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="OMA" id="FSLCRWV"/>
    <dbReference type="PhylomeDB" id="F9ULX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-645-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="27177" checksum="6C329008FCA07229" modified="2011-10-19" version="1">MTMDKILVVDDEPAIVTLLSYNLKQAGYEVVTATDGADALSLGLAQSFTCILLDLMLPKLDGMEVTKKLRQEKVQTPIIIVTAKNDEFDKVFGLELGADDYITKPFSPREVLARIKAVIRRTTPDEPVTPPAPMPPANRAVMLVGDLQIDQNKYRVARNGKNISLTPKEFELLVYFVEREGRVLSRDAILNHVWGYDYASETRIVDIHISHLREKIEADPKQPRLIRTVRGFGYEFVGDGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM10</accession>
    <name>F9UM10_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gapB</name>
        <name evidence="10" type="ordered locus">lp_0789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UM10"/>
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    <dbReference type="MoonProt" id="F9UM10"/>
    <dbReference type="EnsemblBacteria" id="CCC78249">
        <property type="protein sequence ID" value="CCC78249"/>
        <property type="gene ID" value="lp_0789"/>
    </dbReference>
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    <dbReference type="GeneID" id="57024491"/>
    <dbReference type="GeneID" id="66448753"/>
    <dbReference type="KEGG" id="lpl:lp_0789"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.666"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAPDH-I"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
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    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
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            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="13"/>
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        <ligand>
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    </feature>
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        <location>
            <position position="38"/>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="125"/>
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        </ligand>
    </feature>
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        <location>
            <position position="186"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="lp_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="57024522"/>
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    </dbReference>
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        <property type="entry name" value="Cof"/>
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        <property type="entry name" value="HAD-SF_hydro_IIB"/>
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        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
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        <property type="entry name" value="HAD-SF-IIB"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="29631" checksum="21EC55C0E23937B1" modified="2011-10-19" version="1">MAINLIATDLNGTLLHQDQRFDKERFKRVLAQLRAINVSLVLSSGNQYAHLRQLFKDVMADNLIVVAENGASIYAQDRLIFDGSLSADQQRKFVTVDRHQPLFKDAYVILVGSHGSYTELGAPDKLVAMARQFYDHLHLVADLATVDDTVKKISISTSPDQAADLVARANDYFDGELRAHDSGYGVVDLVDQRVGKLPAIQFLATKLGLTAANVMAFGDGANDVPLLRYAAHSYAMCNAPADIQAAAKHVTALDNEHDGVLATIEQELLNN</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC2</accession>
    <name>F9UMC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0923</name>
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    <organism evidence="8 9">
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        <lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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    </reference>
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</entry>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
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                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="CCC78417.1"/>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMK0</accession>
    <name>F9UMK0_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Type 4 prepilin-like proteins leader peptide processing enzyme</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_1023</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="gene ID" value="lp_1023"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_1_1_9"/>
    <dbReference type="OMA" id="VFWLFKL"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="24789" checksum="5C817E6D005DB18E" modified="2011-10-19" version="1">MLTSSLFIIGLCLGSFVTCMAERISNGHILISTQRSRCPHCRHQLRFWQLIPLLGILLQRGQCYDCRTPISLRSSLIELLCGSLLASSSASLSLTLPLLIGYLVLIFNSLTDYLTFEVYPLTLLLPAGLGLWQQRPPLTISLYLVLALLVGLYLLARLTATFGLGDVDVLLMLVFIIPADTLLTCLAIAAVAALVGFIISAPRHRLPFVPFISWSFIMVTQLTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY7</accession>
    <name>F9UMY7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbB</name>
        <name evidence="8" type="ordered locus">lp_1189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1189"/>
    <dbReference type="EnsemblBacteria" id="CCC78576">
        <property type="protein sequence ID" value="CCC78576"/>
        <property type="gene ID" value="lp_1189"/>
    </dbReference>
    <dbReference type="GeneID" id="57024825"/>
    <dbReference type="GeneID" id="66449081"/>
    <dbReference type="KEGG" id="lpl:lp_1189"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1007"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_9"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="PhylomeDB" id="F9UMY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1019-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="5"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="38668" checksum="5253B8C97E04DFA7" modified="2011-10-19" version="1">MENLLVTGGAGFIGSNFVHYVYNHHPEVKITVLDKLTYAGNRANLEEILGDRVKLVVGDICDAPLVDELMQQTDAVVHYAAESHNDNSLKDPWPFIETNIIGTYTLIQSAHKFNKRFHHVSTDEVYGDLPLREDLPGHGEGVGEKFTPTSRYKPSSPYSSSKASSDLLVRAWVRSFGLQATISNCSNNYGPYQYIEKFIPRQITNILSGIRPKLYGSGKNVRDWIHTNDHSAAVWDILTKGKIGETYLIGADGEMNNKDVLEMILELMGQPKDAYDVVKDRPGHDLRYAIDSTKLRTELGWQPEFTDFRSGLKATIDWYTDHQDWWQADKNKVESNYAKNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY9</accession>
    <name>F9UMY9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1191"/>
    <dbReference type="EnsemblBacteria" id="CCC78578">
        <property type="protein sequence ID" value="CCC78578"/>
        <property type="gene ID" value="lp_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1191"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1009"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_41_7_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1021-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="70" mass="8496" checksum="2E3119C8CD95DEEF" modified="2011-10-19" version="1">MSRHRTPYDNAPMERWWNEFKLRWMVSHPMAKTYEELVKLVEAGIDYFNHHNLSAQRNGLTPDEYWSEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN08</accession>
    <name>F9UN08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78597">
        <property type="protein sequence ID" value="CCC78597"/>
        <property type="gene ID" value="lp_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1211"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1028"/>
    <dbReference type="HOGENOM" id="CLU_1003972_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1039-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="33125" checksum="0326C1D10401E2D6" modified="2011-10-19" version="1">MPIKYSSQFELLLFYSDAFSNPWFLNQKLILVDHKISKLQASHHEMQFQVETTVIEWQRYRIHVMKELKLSPNTVQEFCQLNRDDLVVSDYFVENCREHNDIERAIMYCRTGIQQAAQDDNSTVMYHCYDQLVSLYRDCGLVNEYRHALFEAITKCDALNSNWYIQLREQYSSADWSNVRRQISASIIPQTDFEWDSFQNVSVRPYVLALQRDVKEATTPESQLSIIKQLDYLQKYHGSTGLEVADWLWQDWYRHYPERKVLIDAFDEWIAQIIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN11</accession>
    <name>F9UN11_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1214"/>
    <dbReference type="DNASU" id="1063075"/>
    <dbReference type="EnsemblBacteria" id="CCC78600">
        <property type="protein sequence ID" value="CCC78600"/>
        <property type="gene ID" value="lp_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1214"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1978714_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1042-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14694" checksum="D4D1D18F4EC791A9" modified="2011-10-19" version="1">MGRKGSRYTIKEKLFYIGLVTQGMAPNAVQRKYGVEHSQVSRWVKCYGLQGIDGLRHRLMGKYPSELKLKIVLEYLEGHSSYPRLCDKYNIPTIYQWIHQYTSGKQLTTRSVKQVKDGRKQPSWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN22</accession>
    <name>F9UN22_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644185.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1228"/>
    <dbReference type="EnsemblBacteria" id="CCC78611">
        <property type="protein sequence ID" value="CCC78611"/>
        <property type="gene ID" value="lp_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1228"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1041"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132477_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UN22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1052-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="28782" checksum="A573FF20417A3475" modified="2011-10-19" version="1">MNIARFTPLRISSSEQEFILNFSLLEHDLIHFFKIRDFDHAISRINKFKEVHPINCIDAEILNQLLLGLIGSLTAASYTHNLNLNDFLKLRLYFFNFIKKSPCTSSTFWPLSNDIITTYFNLLDNFDFHVSYQNLSKQVALTAYYISAHPQELTNSHGVLHTLNLNNDYTQKLFKKELGFSINAYIQHIKLSEAKRLLLQRQLSVGKIASLLHFYDTPTFSKTFKKAVGLSPLKYRELNYLSLTSQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN48</accession>
    <name>F9UN48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643233.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889151.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1258"/>
    <dbReference type="EnsemblBacteria" id="CCC78637">
        <property type="protein sequence ID" value="CCC78637"/>
        <property type="gene ID" value="lp_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1258"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1067"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="PhylomeDB" id="F9UN48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1078-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="32473" checksum="E68C06D0B886C44B" modified="2011-10-19" version="1">MNLKQLQYFLAVAEEGQMTAAAKRLHVAQPPLSYQIKQLELELGVTLFNRLPQGVTVTEAGKLLVGYAQQLTQLSATAENKVRALAHGVTGTINLGTVSSSAGVMPNTALLKWLGQHPDVQLAITEGNTYELLDDLHKRLLDVAVLRTPFNAQHLVCRYFPAERMAAVIPKRYSRFEKRRQLQLSDLATLPLIKYRRFNELFHVAFLEASVTPTYIMTCDDARTAMHWANHQLGVALVPRSLAETYDGGDVLIRSLADHRFQTQLALATTPEALATPLVAGLMAQFQQAQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC1</accession>
    <name>F9UNC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pltR</name>
        <name evidence="6" type="ordered locus">lp_1356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101371.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1356"/>
    <dbReference type="EnsemblBacteria" id="CCC78710">
        <property type="protein sequence ID" value="CCC78710"/>
        <property type="gene ID" value="lp_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1356"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1141"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="YIMINDY"/>
    <dbReference type="PhylomeDB" id="F9UNC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1168-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="29169" checksum="226345975915D189" modified="2011-10-19" version="1">MLKTFVVEDDPEQLATLKQIIKNHIMINDFDMELTLATGQAQTLLDYVETNSDLEGLYFLDIEYPGQDLNGLALATRIREADVNARIVFVSTHSEMAFLTFERRIEPLDFIVKDLGQETVKAKVETDIRVAYERYTKQAVTSRAMFSYSKGGQLFNVPLDQVLFIETGAVRNKLVLHLTDRIVQYNGKISDETVAHPELFRVHKSFLVNPQMLVRIDKQHQLGYFENGESVDIAIRKMHDLIALIKRSELAVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE9</accession>
    <name>F9UNE9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1395"/>
    <dbReference type="EnsemblBacteria" id="CCC78738">
        <property type="protein sequence ID" value="CCC78738"/>
        <property type="gene ID" value="lp_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1395"/>
    <dbReference type="eggNOG" id="ENOG5030A14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2155149_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="12495" checksum="6279DB27DB9B3EEE" modified="2011-10-19" version="1">MPLAQQIILTYSTETDVNTLLYQDLGALQFSMEYTLTNPKIYTVLNRYPAPVAVRSAMTASDLLPFHRQFQTRHAEFAAMNLEPLGMLTDARQHPEKVLADATQILTKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG6</accession>
    <name>F9UNG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1416"/>
    <dbReference type="EnsemblBacteria" id="CCC78755">
        <property type="protein sequence ID" value="CCC78755"/>
        <property type="gene ID" value="lp_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1416"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1187"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_4_1_9"/>
    <dbReference type="OMA" id="MIKFIHC"/>
    <dbReference type="PhylomeDB" id="F9UNG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1216-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014576">
        <property type="entry name" value="Pesterase_YhaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033091">
        <property type="entry name" value="Pesterase_YhaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="406" mass="44516" checksum="87DE0692A9A76482" modified="2011-10-19" version="1">MKFLHAADLHLDTPFQGLSGLTPALQERLVTAPLRALSRLVDLAVAEQVDFVLLVGDLFDQQGQSVQAQAALMTALARLNTASIPVLLSFGNHDFQADLSRWHFPANVHVFGPQVTTATLTTVAQERVAISGFSYAQRWVTTDPVDDYPVKATGVDYQIGTLHGQIGVAGDHYAPFNVSELLTKHYDYWALGHIHQRQTLNSQPPIVYAGNTQGRHRGETGAKGCLIVNSQADQTLQPVFHALTDIEWADWTPTLTSPEPMSRSHIVHQLADQLSLKMVTGLKLVTITLPASLQLSAMAELALNQGAILAQLQEQANEHWWPVAIEQATTDTMTPLFGINATTWQQVGEQVVTDQAVAELAGKLLDEDFLNTALLEDMSPTAWQQQVVRLLNDQYHLTTGVNDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH4</accession>
    <name>F9UNH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1426"/>
    <dbReference type="EnsemblBacteria" id="CCC78763">
        <property type="protein sequence ID" value="CCC78763"/>
        <property type="gene ID" value="lp_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1426"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1196"/>
    <dbReference type="eggNOG" id="ENOG50309PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121384_0_0_9"/>
    <dbReference type="OMA" id="ADNITHQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1224-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="20722" checksum="CA9E9B17A3D0C002" modified="2011-10-19" version="1">MQKLMPVAVTNIADNITHQPAYMTIVLNDHKYSTARKKTPFILKALNEGAAAHGRLTITPSRLSLADERGTVFQTLAPIPTVITDVELGLYRSIVRQLGNGVRMKARYTLAVTLTSDTATYQMLNTDLSVLKPLLAWITDFHLHLTDSLQLATSDIDWPNLTADQFEALTKGTPYFAWQQTIGAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR2</accession>
    <name>F9UNR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889365.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1527"/>
    <dbReference type="EnsemblBacteria" id="CCC78851">
        <property type="protein sequence ID" value="CCC78851"/>
        <property type="gene ID" value="lp_1527"/>
    </dbReference>
    <dbReference type="GeneID" id="57025122"/>
    <dbReference type="GeneID" id="66449418"/>
    <dbReference type="KEGG" id="lpl:lp_1527"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1285"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_4_0_9"/>
    <dbReference type="OMA" id="VLNPYHI"/>
    <dbReference type="PhylomeDB" id="F9UNR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1312-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="176" mass="19985" checksum="F436AAC014B73A7B" modified="2011-10-19" version="1">MIKQFKPTWMIPAIYNVTPAQLRAQGIKAVFTDLDNTLIAWDNPDGTPELKKWLHALQDAGIPLVVVSNNSEARIAKALQSLELPFVSRSLKPLPLGISKARHDLGLHKNEVVMVGDQYITDMWAAHLAGVPSILVQPIVKTDAWNTRINRFFERFIKLRLAHVYPEMHFQEDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS5</accession>
    <name>F9UNS5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="3 7">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gnd2</name>
        <name evidence="9" type="ordered locus">lp_1541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 7">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889378.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1541"/>
    <dbReference type="EnsemblBacteria" id="CCC78864">
        <property type="protein sequence ID" value="CCC78864"/>
        <property type="gene ID" value="lp_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="66449430"/>
    <dbReference type="KEGG" id="lpl:lp_1541"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1298"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_9"/>
    <dbReference type="OMA" id="VIMVKAG"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="182"/>
            <end position="475"/>
        </location>
    </feature>
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            <position position="186"/>
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        <location>
            <begin position="12"/>
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            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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            <begin position="35"/>
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        <ligand>
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            <position position="104"/>
        </location>
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        <source>
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            <dbReference type="RuleBase" id="RU000485"/>
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            <dbReference type="SMART" id="SM01350"/>
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        <source>
            <dbReference type="EMBL" id="CCC78864.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="478" mass="52982" checksum="3D871216F03D0431" modified="2011-10-19" version="1">MSNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIEDFVASLETPRRIIMMVKAGKPTDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKSGINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEKISAKAPQDGAPCVTYIGPNGAGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITADILSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMKNERVAASKKLAGPTADVDLPAKEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLKFGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDYFADIAAKYQQSTREVLSLAIQAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP75</accession>
    <name>F9UP75_LACPL</name>
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        <submittedName>
            <fullName evidence="8">1,4-dihydroxy-2-naphthoate octaprenyltransferase, UbiA prenyltransferase family</fullName>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ordered locus">lp_1715</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCC79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC79014">
        <property type="protein sequence ID" value="CCC79014"/>
        <property type="gene ID" value="lp_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1715"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1449"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="KIWVAST"/>
    <dbReference type="PhylomeDB" id="F9UP75"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
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        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="34392" checksum="BF2637DDF4ED85AD" modified="2011-10-19" version="1">MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAVNVSDNYYDYRHARDREGYAQKTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWLVLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLIELTCVVVSTYGQHPLTWSIVGTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIWPLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFVLGTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG1</accession>
    <name>F9UPG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribitolphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tarK</name>
        <name evidence="6" type="ordered locus">lp_1818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889614.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1818"/>
    <dbReference type="EnsemblBacteria" id="CCC79100">
        <property type="protein sequence ID" value="CCC79100"/>
        <property type="gene ID" value="lp_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1818"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1536"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029598_0_0_9"/>
    <dbReference type="OMA" id="PFESCLL"/>
    <dbReference type="PhylomeDB" id="F9UPG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1563-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="42756" checksum="612B9037B2C746AF" modified="2011-10-19" version="1">MGRLKTVKLVLLHTSFNLFYQFFYKVFGPKKGRITLATMRSGQLNDNLAALEQGLKTANVKPVTVFCYHYDRTLAGKVGFLLASIKALYVIARADVFVIDDYFFPLYAIHKHDDNQVVQLWHAIGSLKKFGLSLPNADQSVMKPHTNYDWVLINAKSDQPAYLDAMAINQDHVIATGSPMVDSLLNRQPQQPRLAARRILYSPTYRQGVQGKQQVMGYVNNMIAACQQLTGPWELYISLHPYLKLSAMTLPSNVHIFQDAERVKTLMPTIDLFITDYSSLSLTFSYFERPIILYTPDYDDYMQTSGFYVDYYQYLQAPHFSKAARVVDFINQEVDHMDLSYVHELKQKTFPHQDGHNTERVVQFVEKLAGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS3</accession>
    <name>F9UPS3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889726.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1956"/>
    <dbReference type="EnsemblBacteria" id="CCC79212">
        <property type="protein sequence ID" value="CCC79212"/>
        <property type="gene ID" value="lp_1956"/>
    </dbReference>
    <dbReference type="GeneID" id="57025537"/>
    <dbReference type="KEGG" id="lpl:lp_1956"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1652"/>
    <dbReference type="eggNOG" id="ENOG5030A9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787065_0_0_9"/>
    <dbReference type="OMA" id="MTMLVGY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1676-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="352" mass="40151" checksum="C38E7F254DB70283" modified="2011-10-19" version="1">MNKKLGHLIIWQHAPLLIGMLILFIALGAWTGFRMNQHWQMLDQNHDMLISGLKYDHRRQQYQDVDGLVAPSKQQYLNQYLQVYHADRRGLLANLRVGSNVEPNDFLWGISILVGIALIAIPRYRHQNEWLQSLGFRRAAIFGATFLSYSLTTIIAYSLAKLMVLLVLVQNIPGIYFAQFNWWVWGGNVISTTLVALILMTASALVLLVTPNLVMAMLVGYAIVKPISWFVLIRSFGQPGNYLLAFLNQHWLLGIAIGCLVWGLGGILGRYLSAQQITERNHQAILLPAWRVPMLIGLSIILTKLITDVMLAPQTSWSYVAVVWSATLIGLIAWIYQPRWSRYFWQVVRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPT3</accession>
    <name>F9UPT3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dgk</name>
        <name evidence="12" type="ordered locus">lp_1968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101609.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1968"/>
    <dbReference type="EnsemblBacteria" id="CCC79222">
        <property type="protein sequence ID" value="CCC79222"/>
        <property type="gene ID" value="lp_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1968"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1662"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_2_9"/>
    <dbReference type="OMA" id="SFRYAAQ"/>
    <dbReference type="PhylomeDB" id="F9UPT3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1686-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="138" mass="15446" checksum="84A15CE7E435D03C" modified="2011-10-19" version="1">MASKNRPDRLQVGKNHSFWQSWLHAWTGLKTVVIEERNMRTHLVLGAVALFAGWWVHLSVNEWLWLALAIFLVILCEINNTIAENLSDMITGPNFSPLAKKIKDIAAGAVVFAAAFAVLVGLVLFAPKVWNLIVSWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV0</accession>
    <name>F9UPV0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">relA</name>
        <name evidence="9" type="ordered locus">lp_1987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640696.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889753.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1987"/>
    <dbReference type="EnsemblBacteria" id="CCC79239">
        <property type="protein sequence ID" value="CCC79239"/>
        <property type="gene ID" value="lp_1987"/>
    </dbReference>
    <dbReference type="GeneID" id="57025564"/>
    <dbReference type="KEGG" id="lpl:lp_1987"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1679"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_9"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="PhylomeDB" id="F9UPV0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1703-MON"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="8">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="755" mass="86282" checksum="90771358AC1CC293" modified="2011-10-19" version="1">MPKQPTWTAQDVLDMVQKYMNSDHVALVKRACDFATYVHKDQYRQSGEPYIMHPIQVAGILAELKMDPETVASGFLHDVVEDTGVTLGDVEELFGHDVAVIVDGVTKLGKIRYKSNKEQLAENHRKLLLAMSKDIRVMIVKLADRLHNMRTLQHLRPDKQRRIANETLEIYAPIADRLGISTIKWELEDISLRYLNPQQYYRIVHLMNSRREDREKYIEIAIQDIQKALHDLELPEAEIYGRPKHIYSIYKKMRDKHKQFSQLYDLLAIRVVVDSIKDCYAVLGAIHTQWKPMPGRFKDYIAMPKANMYQSLHTTVVGPEGKPLEIQIRTFEMHRVAEYGVAAHWAYKEGKRDEVQETQSGNKLNLVKEIIELQDESKDAADFMEGVKGDLFSDRVYAFTPKGDVTELPKGAGPLDMAYSIHTEVGNHTTGAKVNGKIVPLDYQIKNGDIVDILTSTSSTGPSRDWQKLVYTRRARNKIKQFFRNADREENIITGRDLLEKQLRDLEFNPKEIMTKDKVTAVAQKMHYGSEDDLFAALGFGDVQPVGIANRLTSDVRKQREANRQREREEAILADSTEAPAKKKSKDHHNEDQEKQDRKRQKVSSSGGVIIQGVDNLLVRLSHCCSPIPGDEIVGYITKGRGVSVHRVDCPNVKSAEANGERLIDVQWENPEGDRTNYNSDLEIQGYNRNGMLNDVLKVINNHTKFLTNVNGKVDHNKMVIISVSLGVRNLEHLQRIIDSLKNVQDLYVVERKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ36</accession>
    <name>F9UQ36_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recJ</name>
        <name evidence="10" type="ordered locus">lp_2087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101649.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889839.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2087"/>
    <dbReference type="EnsemblBacteria" id="CCC79325">
        <property type="protein sequence ID" value="CCC79325"/>
        <property type="gene ID" value="lp_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2087"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1766"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_4_1_9"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="PhylomeDB" id="F9UQ36"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1786-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018779">
        <property type="entry name" value="RecJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10141">
        <property type="entry name" value="ssDNA-exonuc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="85"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="315"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="456"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="ssDNA-exonuc_C" evidence="8">
        <location>
            <begin position="570"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="778" mass="83877" checksum="668425DF4C925232" modified="2011-10-19" version="1">MLAAKKKWVPRLTTAVDEADVDKLAEAASVTPLVARLLIMRGINTAEEAAPFLHADQQPLLDPTNMHDMEKAVDRIQEAIIAGDQITIYGDYDADGLTSTSIMYETLDQIGANVNYYIPDRFKDGYGPNQAAFDRLIAAGTKLFVTVDNGVAGNAVINQVQEQGIDVVVTDHHELPTELPHAYAIVHPRHPEGSYPFGGLSGAGVAFKVATALLEEVPEELLDLAAIGTVADLVSLTGENRTLVTLGLKVLQQTTRPGLAALIQEAGLIPDKLTETNIGFGIAPRLNALGRLQSAQSGVELLTTLDDERATALAKQVNQLNEKRQGLVKTISASAIEQAQTPENEARQTLVITGHGWHEGVLGIVASHVVETTGKPTLVLNEDDDGRLKGSGRSVEAYNLFAAIDPVRESLVAFGGHHMAVGLTVMADQLATLKEAMEVAAVSQQLADNAQVSLPIDGTLPLAEATLATLADIQALAPFGTDNPAPLFELVPTTVPHARAIGSDQQHLKLQLGDGTNTIDAIGFSMGTALPAIQASPTDVTLVGELSENTWNGQTKPQIMVKDIAVTGTQVIDARTQHLSAHLFQAPGVYLFFHQRLLKKVEQYLGSQAQAVWVGDTKTDLTAVTANQAVFIVDCPDTLADMTQVLSTIALDQLTLYLYRQESVYLTGMPNRAQFAKLFQFTAAHHDVDIHHQLTLVAKHLHIERNLLIFMIQVFFEVGFVKINDGVMNGVSNPAKADLHHAPSYQLREQQIVAEETLLYSKSAALQVWVKNQAAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ91</accession>
    <name>F9UQ91_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pdhC</name>
        <name evidence="8" type="ordered locus">lp_2152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2152"/>
    <dbReference type="EnsemblBacteria" id="CCC79380">
        <property type="protein sequence ID" value="CCC79380"/>
        <property type="gene ID" value="lp_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2152"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1821"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_9"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="PhylomeDB" id="F9UQ91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1841-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="431" mass="45971" checksum="307787C9A9D17A4E" modified="2011-10-19" version="1">MAYEFKLPELGEGLEEGEIASWLVKPGDEVKEDDSLVEIQNDKSVEELPSPVSGKVIDILVPEGETAKIGDVIVTIDDGSGDAAPAATKTEAPASEAAETPAATSAQPTGTPAAGNPNKRVLAMPSVRQYARDKDIDITLVTPTGAHGQITKQDIDNYTGAPAATGAKPAATPATTAPAASEAPAPTPVKPYVSDTPELETREKMTPIRKAISKAMVNSKHTAPHVTLFDEVEVSALMAHRKKYKQVALDRDIHLTFLPYFVKALVAVLQQFPELNASIDDANKEIVYKHYFNIGVATDTDRGLLVPNIKHAEGKGLFAIAKEITDNTQKAYDGKLKASEMSGGSITISNIGSIGGGWFTPVINQPEVAILGVGRIGKEPYVNDDGEIVVGKMQKLSLSFDHRLIDGATAQRAMNLLKQLLHDPELLLMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ98</accession>
    <name>F9UQ98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diacylglycerol/lipid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889901.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2159"/>
    <dbReference type="EnsemblBacteria" id="CCC79387">
        <property type="protein sequence ID" value="CCC79387"/>
        <property type="gene ID" value="lp_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2159"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1828"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_0_2_9"/>
    <dbReference type="OMA" id="HRAYICT"/>
    <dbReference type="PhylomeDB" id="F9UQ98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1848-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="36422" checksum="A5E6FBC419628A16" modified="2011-10-19" version="1">MIAEYYIIINELAGSGHGKVVWETVKPILEQRQIRFEYRISEYAGHTIRLANEYVKTIQRRPNVTPVILVIGGDGTLNEALNGIMQVPQAEPIPLAYIPGGSGNDFARGLGMATDPAIALAQVLNNMRPRSLNVGYFHETLKNEHRYFVNNVGLGFDAQIVDDTNRSKKKGRLGRWAYLSNMLAAYSQQEGFPLTVHVNRKRDYYKRAFLCTVSNIPYFGGGVKILPQANLHDNQLELIVVEEPHWWIILWLFVLLLLGGRHLKSRFVHHYRNANLHLLVNSVEIGQMDGQIIGNRNYDLYLSTHPYPFWIDTSIHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD9</accession>
    <name>F9UQD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA large subunit methyltransferase A</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rrmA</name>
        <name evidence="4" type="ordered locus">lp_2215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640871.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2215"/>
    <dbReference type="EnsemblBacteria" id="CCC79428">
        <property type="protein sequence ID" value="CCC79428"/>
        <property type="gene ID" value="lp_2215"/>
    </dbReference>
    <dbReference type="GeneID" id="57025738"/>
    <dbReference type="KEGG" id="lpl:lp_2215"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1870"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050931_2_0_9"/>
    <dbReference type="OMA" id="MTPHGWR"/>
    <dbReference type="PhylomeDB" id="F9UQD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1889-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="97"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="31660" checksum="9861DA9C69055F01" modified="2011-10-19" version="1">MKKIDRGIQFVQANIDRFRCLVCNQAYVTIDGHSLCCPNGHQVDFSKKGTLYFLTHQVASEYDANMLAARRRVLQAGFFGPIVQAINAALPKTAQRILDIGSGEGTPLADLLTMHANSEDVGIGFDISKDGVNLATQLTTTAYYCVADLAQLPFTDGAFTAIMDVFSPSAYQEFERVLAPGGQLLKIVPNPEYLVELRHLLFKPTDRQYQYDNQRVLDLFAQHYPTAKRQRIQYQVALDNIDFNDLLVMTPLHWGADAEQLATAKRQGLTKITVDVSLLTMQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE1</accession>
    <name>F9UQE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889944.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2217"/>
    <dbReference type="DNASU" id="1061494"/>
    <dbReference type="EnsemblBacteria" id="CCC79430">
        <property type="protein sequence ID" value="CCC79430"/>
        <property type="gene ID" value="lp_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2217"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1872"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_2_9"/>
    <dbReference type="OMA" id="WRTLTAY"/>
    <dbReference type="PhylomeDB" id="F9UQE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1891-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="43085" checksum="5D738C4F338746C0" modified="2011-10-19" version="1">MKPDSQKQRWSAQRLIRILVVILLVLTIFFMGKQVDWLLDPVRQFFSIVGLPIILAGVLYYLLNPLVDWLEKRFRVRRTWTIIGLFIVVVALLALGIIAIIPTIRDQTLSIINDWPNYWKNASTEVNRWLNDPQLSSIRDQLESWNTDLSKLVSGRFSKYLTGTVTSLTGVFSTVTTVIIGLITMPFILFYLLRDGHQLPKYMAKFVPTKARSGFLEVLTEINSQVSNYIRGQLTVAFFVAVMFAVGYSIIGLKFALTLGIAAGILNLIPYLGSFLAMVPSVVIALVTSPWMLVQVLIVFVIEQTIEGRFISPLVLGSSLAIHPITILVVLLAAGKIFGLMGVIFGIPGYAILKVLWTHLFDWYRRSSGLYEAEATPSTDQTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE9</accession>
    <name>F9UQE9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF1</name>
        <name evidence="9" type="ordered locus">lp_2225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2225"/>
    <dbReference type="MEROPS" id="M03.007"/>
    <dbReference type="EnsemblBacteria" id="CCC79438">
        <property type="protein sequence ID" value="CCC79438"/>
        <property type="gene ID" value="lp_2225"/>
    </dbReference>
    <dbReference type="GeneID" id="57025748"/>
    <dbReference type="KEGG" id="lpl:lp_2225"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1880"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_9"/>
    <dbReference type="OMA" id="YRQTMFA"/>
    <dbReference type="PhylomeDB" id="F9UQE9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1899-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="207"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="603" mass="67708" checksum="3CE090B6901B72DD" modified="2011-10-19" version="1">MVATKQLPTRSAVPEELTWDLTPIYADQAAYEADIAQVKAAIPTVTALKETFTSSADTVLAGIQAVLALYRRLEKVAVYASLKSDQDTGNSTNAALDDQASSLTAKVSAATAWFEPAILELTPGELDTYLDENVDLRDYRHLLDTIRLQKGHVLSESEEALLAGASDIFGASAKTFGVLNNADFQFPTVKDDDGNPVKLSQGIYGVLLESVHPAVRREAFEALYKVYGQFRRTLASTLASQVKVHNFVAQAHHYPDARTAALAANQIPTAVYDSLVTSVDKHLDLLHRYVALRKQLLGVDQLHMYDMYTPLAPKPTTNYSYQQAQATALQALKILGPDYLKHVKTAFASRWIDVVENQGKRSGAYSSGMYDTAPYMLLNWQDNIDNLYTLVHEMGHSMHSYFTTHHQPYQYGDYSIFVAEIASTTNENLLTNYFLATEQDPKMRAYVLNYYLDGFKGTVFRQTQFAEFEQWLHEQDQEGQALTADRLSKHYLQLNQRYYGDAVVSDPQIADEWSRIPHFYYNYYVYQYATGFAAASTLADRISTQQTDAVADYLGYLKAGSSAFPIDVMHRAGVDMTKPDYLDAAFEVFEERLNEFEQLVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQK7</accession>
    <name>F9UQK7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79496">
        <property type="protein sequence ID" value="CCC79496"/>
        <property type="gene ID" value="lp_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2292"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1939"/>
    <dbReference type="eggNOG" id="ENOG5030A4T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1914402_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1980-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="15402" checksum="6F2E23D8BEB74B60" modified="2011-10-19" version="1">MIKMSGERVSGAWTTQHDWELIVLDMTKLYYRQVYSAYCFLADLPEATPAFVAGRKTLWELNAHPSARDAKLITLNLYEQVAAFELDPNRHDQAAIATINLQRDNAVSGLQPLVQLFGSYPATTKIETLDNWDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW4</accession>
    <name>F9UQW4_LACPL</name>
    <protein>
        <submittedName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Ursing B."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
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                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="283"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="507" mass="57479" checksum="72833543E11DF5FA" modified="2011-10-19" version="1">MKLIYQQMLAFFAVIITVIVVLGFSFIRTTRTMLYQNSWQQLQQYAASIEKEAIRYNTKTNQVVGFNQQFLNDGTVILRDQHIHFSVYDANKKLVYPSGMGTTMSGTPGGSIYDPKISAKDWKKLKRNKIITQSPHVTFRTRNRDQPVNTPSLRTIDVLVPLFYKNGATKKFVGAISIGSFEQTLQANEQQIEKNLFIALLVSGIAALLLSYILARYSVRRINRLRYATHSVANGDFDIQVDSNHKDEIDDLADDFNGMVNSLRTSNEEIKRQEKRRREFMADAAHEMRTPLTTINGILEGLAYDAIPEEDKGHSIELMQNETKRLIRLVNENLDYEKIRTGQIALNKTNFDGAEVLHNLVEQLTKKAAAADDEFKLTVPEKLPVWADYDRFVQVLFNIMQNAIQFSQANVIEVTGSRTDHATVVAIQDHGIGMTPDQVKNIWERYYKADPSRKNTKYGESGLGLAISHQLVQQHGGSIKVDSVENEGTCFTVTFPDEGFDKPIIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR83</accession>
    <name>F9UR83_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101829.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2568"/>
    <dbReference type="EnsemblBacteria" id="CCC79722">
        <property type="protein sequence ID" value="CCC79722"/>
        <property type="gene ID" value="lp_2568"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2568"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2158"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_9"/>
    <dbReference type="OMA" id="GFITMPG"/>
    <dbReference type="PhylomeDB" id="F9UR83"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2214-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="29694" checksum="C80F39FFA0CAA643" modified="2011-10-19" version="1">MKTWFITGTSSGFGKELATIVARQSDTQLIAAARHTDDLAYLDVFDATRIEKVSIDVTNESQIKTGVAQAIQRFGTIDVLVNNAGLGYFSTIEESDMAKVRYMFEVNVMGLANVTRTVLPTMRAHHAGIIINLSSALALTTLPTMGFYSATKYAVEGYSDTLRQEVKDLGIQIMTVEPSGARTQWSGRSSQKMVPTIADYAAFSDAITTVSDSVTQAPGNPHRIAQVMFDQANLAEVPAHLPLGEFAYQGGLANLQSIVSEIKSREDLSLSTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC3</accession>
    <name>F9URC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF2</name>
        <name evidence="9" type="ordered locus">lp_2621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101855.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2621"/>
    <dbReference type="MEROPS" id="M03.A08"/>
    <dbReference type="EnsemblBacteria" id="CCC79762">
        <property type="protein sequence ID" value="CCC79762"/>
        <property type="gene ID" value="lp_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2621"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2201"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_1_9"/>
    <dbReference type="OMA" id="HPYMWAV"/>
    <dbReference type="PhylomeDB" id="F9URC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2253-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="339"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="599" mass="67219" checksum="DCA7A2AF19402CB6" modified="2011-10-19" version="1">MHYSETWDLDSIFAGGIDSPALTAKMSTIKQQLTTTADTLVHWRAAADTPDADWFTQLVNSLQAIQAGIDQATVFVVAYQSAHADDTKAAPLLNQIYQLDNQLNNLLTRFKKQLVKLDQATFDTLVQQPALQAIAFNLTEMRQQGLALLDDDTEALINDLALDGFQGWSDHYDTLVSQIQVPYTDENGITQQLSAGQAQNMLAAAMPNAQRAELMRNWEHAWQTHAAPFADTLNHLAGFRLANYRAHGTTNFLQKPLELNRMSQATLDTMYQVVADSKDILLSYLKRKAQLLGKDQLDWQDIEAPLTLGQLPNQTYDQAADFVINNFRQFSPKMGALAQHALEHRWVEAENRPNKRPGGYMENLPETHESRIFMTFTGSPNDTATLAHELGHAFHGSVIQDLPLWRQDYAMNVAETASTFAELIVADASVKAADDAKTKLTLLDAKMQNPLAMFLDIRARFLFETRFYAARQHGIVTPDTLSDLMLTAQKDAYGNALNTYHPMFWASKLHFYIDDVPFYNFPYTFGYLFSLGIYAQAKTQSDFEDRYIALLRDTANMSTEALAAKHLGVDLTTPAFWQAGVALIKRDIDEFMALSAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE2</accession>
    <name>F9URE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system, N-acetylglucosamine-specific EIIC component</fullName>
            <ecNumber evidence="8">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pts19C</name>
        <name evidence="8" type="ordered locus">lp_2649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101866.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890295.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2649"/>
    <dbReference type="EnsemblBacteria" id="CCC79781">
        <property type="protein sequence ID" value="CCC79781"/>
        <property type="gene ID" value="lp_2649"/>
    </dbReference>
    <dbReference type="GeneID" id="57026041"/>
    <dbReference type="KEGG" id="lpl:lp_2649"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2219"/>
    <dbReference type="eggNOG" id="COG3715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069101_2_1_9"/>
    <dbReference type="OMA" id="NMPIIAV"/>
    <dbReference type="PhylomeDB" id="F9URE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2272-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="269" mass="28762" checksum="63934502C0B32874" modified="2011-10-19" version="1">MQVTLIQGLLIGLFALIAGIDFWLEGLYIFRPMIVCTVTGAILGNLTLGIIAGGLTELAFAGLTPVGGTQPPNPIMAGIMTVVLAYTTGKTPSTAIGLALPFSILMQYIILFYYSAFSVLTKKLDAYAANVETKKFTRLALLPTVLVALTYGVIAFLCVYGAQEPMKALVNSMPVWLSHGFEIAGNILPAVGFGLLLKSMLKAEYVPYLLLGFTAACFIKFGNLMPVAVIGISLAFIEFYHNKKQTDNEKKLKSMIESASGNGDDGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG8</accession>
    <name>F9URG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase with N-terminal regulator domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890321.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2683"/>
    <dbReference type="EnsemblBacteria" id="CCC79807">
        <property type="protein sequence ID" value="CCC79807"/>
        <property type="gene ID" value="lp_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2683"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2246"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_9"/>
    <dbReference type="OMA" id="YTQQPFP"/>
    <dbReference type="PhylomeDB" id="F9URG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2298-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="455" mass="51362" checksum="54865F9055C13792" modified="2011-10-19" version="1">MMPLNRQSTTPLYIQLYQQMRDDYDATQANHQLWSIRKMAQNLGVSKTTVEQAYDQLLAEGYVYTVPGSGYFYRDRTHWPAAKQALETVPQPTKPRAFTYDFRYGVTQLLSPSWNAWKRAVRLALRQTEQQPTAVYPDAQGLPALRENLVRFLKTTRGVRCTADQIVITSGAKAGLSILLSILPRGTVGIENPGYRGLSELAASYGQTAVPIRVTEDGLDLTQVRARNPQIIYTTPGHQFPLGVVLPIEKRLALLQWAGTQHLIIEDDYDSEYRYSAHPLPALQSLATANQVAYLGTFSRGIDPTLRMGYLVLPPQLVATYHQRYQYRAEMVAGLLQQAMANYFEDGAYYRHLSRNRAANRQKYRVLCHQLAQTKQIRPIATGAGVHLVVQIPGIAQAKLLEALEQQQVRIYPLSSNWRDMPTTDYYLLGFAGLTLSELTTGVKRLVQVCEQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ9</accession>
    <name>F9URQ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101917.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890412.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2793"/>
    <dbReference type="EnsemblBacteria" id="CCC79898">
        <property type="protein sequence ID" value="CCC79898"/>
        <property type="gene ID" value="lp_2793"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2793"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2338"/>
    <dbReference type="eggNOG" id="ENOG502ZH17">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386257_0_0_9"/>
    <dbReference type="OMA" id="IYRISTQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2389-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="717" mass="76253" checksum="96794BF97E5B5C3A" modified="2011-10-19" version="1">MVLSRKNKKEGLGRRLWNSITEPIPDDDSTEQDNEQIPLAYDLKDSAASKADEAEAKSTVNIPRSTANNSAEKQPVDAVIEPEKVAKKARHSGDDRQAAKQSTAPVKHGATSAVKQKGSAGSQSSAKAESAQITKKSAATKPASTASQAAPKTASAVSSQAVSDQRFKHAASTTASAAQSAPARAAKEASQATSTAVSDQKRVAKTTASTKVHQSAATSEVPMTRMARRASQEAASQAKTHSQQSSASTSSAAAAASAVAQSTAPKSTAPKSATSKAAVSQATATTAKDPQATAAKQPKVERRIPADHIPPVARKQQPRIAVKGTEQADDDTQPELPLSREELYGDQQPNGGKQPNKPTMSRVARHEEQRVPHDDQPDDDRDFSELETDEKNPHLKKPARRYNWKLMLAGVAILVVAAGGAFFMWNHGQATQAAARTNAEKIVDQVYTSSAQRDLRASASSSTLTKLQNNIDNMKDSSEKTRLQKQHDTAAKMLTVRTSYQDLRNAKGLLKTDVTMDTITKGQQRLTTAGLTTSKPYFAKKYDKLFTTTGKTVKKVVSYDADFQKLYNKKNKLKASTPSTTVDKVLANLKAYRKKSQLAANDYQKLITDRKKLAKANNASSSASSSSTYSYSEPESSSSSSYSTYSESSDNSSSASTHSYSNDTDTSSATSSSSTPSYSYSANTDSSSTTNYGDTSSTTTGGTASSTDGYSTATGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR5</accession>
    <name>F9URR5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642526.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890418.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2799"/>
    <dbReference type="EnsemblBacteria" id="CCC79904">
        <property type="protein sequence ID" value="CCC79904"/>
        <property type="gene ID" value="lp_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2799"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2344"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020854_0_1_9"/>
    <dbReference type="OMA" id="IVMPMRY"/>
    <dbReference type="PhylomeDB" id="F9URR5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2395-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="478" mass="53002" checksum="5D009E1D2E18512D" modified="2011-10-19" version="1">MANEKQLRWSNIALIAFVAVWGLGNVVNNFALQGLSVVTSWILIMIIYFIPYTLIVGQLGSTFKDAEGGVSSWIRATSTKRLAYYAAWTYWIVHIPYLAQKPQGILIAFSWLFRGNGNFVNTTPALVVQAICLVLFLFFLWIASLGLTTLKRIGSVAGTGMFIMSILFIILAVSAPFMTKATVQTPNMFSLKSYLPKFDFTYFTTVSMLVFAVGGSEKISPYVNKTKNPGREFPLGMLVLAGMVAICALLGSFAMGILFNSKHIPADLMANGAYYAFQRLGAFYHVGNLFLILYAIANVLAQISALAFSIDAPLKILLGDADPEFIPKKLSKMNKKDVPVNGYILTGVLVSILIIIPALGIGNMNELFNWLLNLNSVVMPMRYLWVFLAYMLLNKHLKEFKSDYKFLKNPVAGRLVGAWCFLFTAFACILGMVPKTSYASNPSSWLFQLTLNILTPIIFVALGMILPMIARRHRTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY7</accession>
    <name>F9URY7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644847.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2893"/>
    <dbReference type="EnsemblBacteria" id="CCC79976">
        <property type="protein sequence ID" value="CCC79976"/>
        <property type="gene ID" value="lp_2893"/>
    </dbReference>
    <dbReference type="GeneID" id="66450513"/>
    <dbReference type="KEGG" id="lpl:lp_2893"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2420"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_9"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="PhylomeDB" id="F9URY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2473-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="595" mass="68094" checksum="36E1CFE6191C20F2" modified="2011-10-19" version="1">MAARQSVWARSMPVKEQLTVIRRLLPYAKPFKWFFIAAIVFSGLISVVNIYLPRVLQTFIDHYLKTGHATVPVMWYFAGLYFFGMVVRALMQFVQNFSSTMGAEYMLENVRRQMFAKLHRMGMRYFDQVPGGSILSRLTNDTMSFSNFWALFNTLFTAFFAVISSFVAMYLTDAQIALWLLVFMPFLAVTIWYYQRYSSRVYRRMRERLSELNTKLSEAITGISVIQQFRQEHRINGEFDHTNDAYFKTRQAMIRTNSLLLSPLIDLFYALGTVMVLGIFGVRGLNGYVAAGVVYAFITYLNNFYNPMTSMMDNLSDFQDGVVAGSRVLRVMDDPTIAPAQHADPTAKITRGKIEFRHVTFAYDGQHPVLKDVSFVAEPGQTVALVGQTGSGKTSTINVLMRFYEFQSGEVLIDDRDIREYPAEELRQKMGLVLQEPFMFYGDINSNIRMFNDQISDEQVQAAARFVKADDFINDLPENYQSRVIERGASYSSGQRQLISFARTIVTDPKILILDEATANVDTETEEMIQTGLDRIQENRTTIAIAHRLSTIQNADLILVLNQGQIVERGSNDELLQQHGYYYDMIQLQNSAHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F9US38</accession>
    <name>F9US38_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">lp_0007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641633.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0007"/>
    <dbReference type="EnsemblBacteria" id="CCC77585">
        <property type="protein sequence ID" value="CCC77585"/>
        <property type="gene ID" value="lp_0007"/>
    </dbReference>
    <dbReference type="GeneID" id="57026869"/>
    <dbReference type="KEGG" id="lpl:lp_0007"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.6"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_9"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="PhylomeDB" id="F9US38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-6-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="14"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="811"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="529"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="853" mass="94523" checksum="639F88E067DF40A8" modified="2011-10-19" version="1">MADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGVTPDKPYKKSARIVGDVMGKYHPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPAVLPARFPNLLVNGATGIAVGMTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGRGNIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDREGMRIVIDVRRDASASVILNNLYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQEDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIRQSQTSEIAKNQLMDNYGLSDKQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRKFGDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMDVHDDDFIEHLLTTSTHDVLLFFTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKIQAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSNGLKAITLKDDDELIGVTITDGHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITEKGYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNIATVSQTGRATLGVRLMRLGDDGQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADATTTEPTTDSNDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9US64</accession>
    <name>F9US64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of two-component system, YycI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646175.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0039"/>
    <dbReference type="EnsemblBacteria" id="CCC77611">
        <property type="protein sequence ID" value="CCC77611"/>
        <property type="gene ID" value="lp_0039"/>
    </dbReference>
    <dbReference type="GeneID" id="57026897"/>
    <dbReference type="KEGG" id="lpl:lp_0039"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.33"/>
    <dbReference type="eggNOG" id="COG4853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078250_1_0_9"/>
    <dbReference type="OMA" id="TWHIVVN"/>
    <dbReference type="PhylomeDB" id="F9US64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-33-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018604">
        <property type="entry name" value="YycI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09648">
        <property type="entry name" value="YycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="YycI" evidence="2">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="31477" checksum="030EC9C61DFA499D" modified="2011-10-19" version="1">MNFRRIEWIFLLAFVVLDIFLGFMFVQTSSKSTQTTGDTATTIIREMRADNISFKNPDTSEGTGYYIAGSNESGLKQLLSQLTEQTARVQSGGKLVSTLRATTTIDTRNPKADLTTFMSQRTNVIHGTEYVYDADLSSNGDYVFVQKVADGEIMTGAGQVHLFVNKNKQLTSYTQTYVNHVKTLREKAVTISEKKALVALYQYNQVASSSRIVWAKLGYSRLLKLKDSSVYVPTWIFAVRGKNSSNVTLHRINAFTGSSMKNGSTASDTSSLDATVGMMWNAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB0</accession>
    <name>F9USB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101992.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2978"/>
    <dbReference type="EnsemblBacteria" id="CCC80040">
        <property type="protein sequence ID" value="CCC80040"/>
        <property type="gene ID" value="lp_2978"/>
    </dbReference>
    <dbReference type="GeneID" id="57026312"/>
    <dbReference type="KEGG" id="lpl:lp_2978"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2485"/>
    <dbReference type="eggNOG" id="ENOG5030B15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9USB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2536-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388119" evidence="2">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="25479" checksum="ABFFA258117A9C82" modified="2011-10-19" version="1">MKKVVGSLLMTSTILLGALTPIVGHAADGENRSGTTNATATFTANTTNPVDPVDPTDPTKPLDPKPGDGDNGANSGAGLSLIYAPGKLDFGSHEIDVINNQSYKALTGSDGSTVTMGSTSKVGLQVSDQRGTNAGWTLSVAAADGTDGNLSTLKGATVSLPAGTVISSGSEASNGSTGGNGAVGQAVELDLGSQASTSAGASFTGTTSGNVMTAADKSGAGITSDLLDPAAVKLNVVANTAAATTYKGVLNWTLTSSADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC5</accession>
    <name>F9USC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890569.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2995"/>
    <dbReference type="DNASU" id="1063491"/>
    <dbReference type="EnsemblBacteria" id="CCC80055">
        <property type="protein sequence ID" value="CCC80055"/>
        <property type="gene ID" value="lp_2995"/>
    </dbReference>
    <dbReference type="GeneID" id="57026326"/>
    <dbReference type="KEGG" id="lpl:lp_2995"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2500"/>
    <dbReference type="eggNOG" id="COG0398">
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    <dbReference type="OMA" id="YMIPFIP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2550-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="24617" checksum="86C2FA2369C81490" modified="2011-10-19" version="1">MKVKITKRQLISGAVLLALLLIGLLIYRYHGTWEIIQHRVFDQSALVAQVRRHRAIDILLVVPLLICFSIIPGAPVATISVVAGICFGKGLGAVLNIIGITLGNLIAQRFFGRVTARRDQQPSKLVTAIGKMRHPLLGIVIGYTIPFIPTSLVSLAAIETAVTPRQLAAATLLGSMPTAIIYAWGGDELIKAHFKNALMLVGLLVLLLGLLWLIHHDRQRAVDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF2</accession>
    <name>F9USF2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC80082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643370.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3025"/>
    <dbReference type="EnsemblBacteria" id="CCC80082">
        <property type="protein sequence ID" value="CCC80082"/>
        <property type="gene ID" value="lp_3025"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3025"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2528"/>
    <dbReference type="eggNOG" id="ENOG5031SH3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147324_0_0_9"/>
    <dbReference type="OMA" id="VGVWINH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2576-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388122" evidence="2">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15949" checksum="922F30E81D7D6048" modified="2011-10-19" version="1">MNKKFMQTIFQIIVTVAALVVIVYAVQQHSPTTDKSNQATKQQTSVTHSDNSHLTEADVVGVWINHHNKDIHQQITFTADHKWKENQHHVTNIYSGTWKIIGHNQISLSPYGEKIQLSGHDFSTMDVLNYHHILNKQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
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    <name>F9USH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102019.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890614.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3048"/>
    <dbReference type="EnsemblBacteria" id="CCC80100">
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        <property type="gene ID" value="lp_3048"/>
    </dbReference>
    <dbReference type="GeneID" id="57026368"/>
    <dbReference type="KEGG" id="lpl:lp_3048"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2547"/>
    <dbReference type="eggNOG" id="COG1396">
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    <dbReference type="PhylomeDB" id="F9USH0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="30105" checksum="278936C84C0C8D55" modified="2011-10-19" version="1">MTLGTALKQARKAQQLNQKQAARGICAQSMLSAIENDRYVPNARLLLALCQRLGVAVSTLSLADDFEISAEQAFNDRVRQMCNAHQYQQLKDWLLQPTTLEHVQTDEQTQAYYYYLGVACWQVDRTSDAAQQNLRLAIGMAAPSSPPTTLTRLALISLAVVKAHHHPQAPVAALVTRALADIDAGAYEENANIVFYLAGLVAYEQHDSQLAVARLTQGLAFATTHDSHYMLANIYQLMAQLAMAAGETATAQVASQRSQVFKDLFKEQINDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI5</accession>
    <name>F9USI5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3067</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890629.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3067"/>
    <dbReference type="EnsemblBacteria" id="CCC80115">
        <property type="protein sequence ID" value="CCC80115"/>
        <property type="gene ID" value="lp_3067"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3067"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2562"/>
    <dbReference type="eggNOG" id="ENOG50309KJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_3_0_9"/>
    <dbReference type="OMA" id="LLWQDKM"/>
    <dbReference type="PhylomeDB" id="F9USI5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2608-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389100" evidence="2">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="20074" checksum="585D6CF873591B3B" modified="2011-10-19" version="1">MKSMLGHLLMAGTLLLAGSTPIVANAAENRSGNTDIKAEFTKSTSTVTPVDPSNPDVPSTDGDGDNGAAAGGDLSLIFVSKSLGYGTHELDVLNDQQYKVDPTSSYTLLWQDKMVVEVSDVRGTNAGWKLTVTGSNLTGTDGTAAKGATLSLPKGDVVNSGSEANGAVATASEVALNGTVGSSAVLNADKGGGSGVTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ9</accession>
    <name>F9USJ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface protein, ErfK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890643.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80129">
        <property type="protein sequence ID" value="CCC80129"/>
        <property type="gene ID" value="lp_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3084"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2576"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089260_0_1_9"/>
    <dbReference type="OMA" id="PIDWQKS"/>
    <dbReference type="PhylomeDB" id="F9USJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2622-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
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        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388125" evidence="3">
        <location>
            <begin position="34"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="84"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="23468" checksum="E3964006E1274B0D" modified="2011-10-19" version="1">MQRKSTLILLTSITLVIGLLAVGTVKVVGDAHRPSQSTVTTKKVVSKTKAKTTAKSTVMRTPINWRQSSETVAYPNVNRYPDLWIHVSLAKQRLYLMNHHHVLYTMYASSGVPTADRKTPRGTYHVQAERGKYFYSASVDEGAYYWVSWLNHGEYLFHSTPVDAQGHFIKSDAADLGKRPSSHGCIHLSVADSKWVYNNIKYGTKVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN6</accession>
    <name>F9USN6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="4">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890680.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3125"/>
    <dbReference type="EnsemblBacteria" id="CCC80166">
        <property type="protein sequence ID" value="CCC80166"/>
        <property type="gene ID" value="lp_3125"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3125"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2613"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_3_9"/>
    <dbReference type="OMA" id="CDPKTFV"/>
    <dbReference type="PhylomeDB" id="F9USN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2659-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="493" mass="53243" checksum="155C2D0B19B630BD" modified="2011-10-19" version="1">MTLAKHDSYDIVVVGTGAAGTAAALEAAQHGASVLLLEKGRHTGGSSNYTEGLFAVDSYLQKAQNINVSATDVLKEEVDYSKYRADSRIWRRYLDDSANTVQWLKDQGVEYEGVQAMGAGEATWHIYKGMGQAVLHDALQPQAQKLGVELLTSTTAITLHQATDGAITGVMIQSAATNETQVINTAAVILATGGYLNNPDMMQKLTHYDTRRLIPVSSGKGTGDGLRLAWQAGAQQYGTGMAMLFGGYLKDPSEPSFKYMASQMETAAGQQPLLWLNEHGERFVDEAVVYNFSYAGNALYTQNQVFSILDQGVINKMAQDGNFMGLGVYVRRGEKMTKLQAEIDAAVAANKPFIFKANTIEALATKMHLPVDQVTHSIQTYNQYCDNGQDDDFGKNPEYLVKVSQGPFYGFELNVGAFCTMGGLKVTTNNEVLDTTGQPITGLYAAGNDAAGLTGDTYGPNMPGTCVGYAFYSGRNSGRHAAQYTHQQSIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP2</accession>
    <name>F9USP2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbg7</name>
        <name evidence="3" type="ordered locus">lp_3132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642374.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890686.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3132"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80172">
        <property type="protein sequence ID" value="CCC80172"/>
        <property type="gene ID" value="lp_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3132"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2620"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="VYQALHH"/>
    <dbReference type="PhylomeDB" id="F9USP2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2665-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="483" mass="55387" checksum="AE85B319CB039C6D" modified="2011-10-19" version="1">MGLRKDFLWGGAIAANQVEGAWNIDGKGLSVADVATYKPNVDVKDYRKQVGVTKSDIEKAIQDTDTKYYPKRRGIDFYHRYPEDLELFHEMGFKALRLSIAWTRIFPTGEEFEPNQAGLDYYKAMFNKMHELGIEPIVTLSHYEMPLALASKYNGWENRKVIDLFVRFCKVCFETYKNDVKYWLTFNEIDSVTRHPFTSAGIIPDQTDNLLQAEYQAFHHQFVASALVTKSCHEVIPGSQVGCMLTKLTDYPNSSDPRDVLASFNKNTMNYFPADVQVFGEYPPLVLNYFKKQKIHIDMTASDLEILKENTVDFVTFSYYMSLVSSYDENNLTLTTGNTIVGGKNPHLPVTEWGWTVDPVGLRISLLQLYDRYHKPLMIVENGMGAKDELTADQKIHDDYRIKYFRAHFNEMIKAVDAGVDLLGYTSWAPIDLVSASTSQMSKRYGFIYVDEDDLGNGSLKRYRKDSFTWYQKVIQTNGTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ8</accession>
    <name>F9USQ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100868.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888153.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0074"/>
    <dbReference type="EnsemblBacteria" id="CCC77639">
        <property type="protein sequence ID" value="CCC77639"/>
        <property type="gene ID" value="lp_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0074"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.61"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_2_9"/>
    <dbReference type="PhylomeDB" id="F9USQ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-61-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="35953" checksum="11AA509CA519ADAF" modified="2011-10-19" version="1">MNRSERLNQELIFLSYRQEFHIKELMQEFNISKRTALRDVNSLEQLGLSIYVEPGRYGGYQIMQQQLWVPILLNSQEINALFFALKALSLLSATPFEKSYHTIYKKLMATLSLSNQRQVAKLQRVVNYYSIPNLDAPTHLSDLLTAILDENVVQLTMTTVTAGFQIFDLLYRHGIWFFSGVNLDNNAWGIYRCDTIKVFQTSEQPARYTWKQLAQRQRSYDHHHHNIRYKCALTPPGREHVQKNNYPNMHLTHQNDQDYLIGGYNQDELAYMVDYLLGLGRNVRIIYPEALKTAYLQELQQIQDFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST3</accession>
    <name>LARD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">D/L-lactic acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lactate racemization operon protein LarD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lactic acid channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">larD</name>
        <name evidence="5 6 10" type="synonym">glpF1</name>
        <name evidence="10" type="ordered locus">lp_0108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6750" last="6761">
            <title>Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Goffin P."/>
                <person name="Deghorain M."/>
                <person name="Mainardi J.L."/>
                <person name="Tytgat I."/>
                <person name="Champomier-Verges M.C."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="16166538"/>
            <dbReference type="DOI" id="10.1128/JB.187.19.6750-6761.2005"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transporter that facilitates the transmembrane diffusion of D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes. Also facilitates urea and H(2)O(2) diffusion across membranes, but is not permeable to water, glycerol and dihydroxyacetone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced by L-lactate and repressed by D-lactate. Is thus regulated by the L-lactate/D-lactate ratio. Makes part of the lar operon (larABCDE).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Cells lacking this gene show a decreased lactate transport ability (PubMed:23799297). Deletion of this gene does not affect lactate racemase activity (PubMed:24710389).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UST3"/>
    <dbReference type="SMR" id="F9UST3"/>
    <dbReference type="STRING" id="220668.lp_0108"/>
    <dbReference type="EnsemblBacteria" id="CCC77664">
        <property type="protein sequence ID" value="CCC77664"/>
        <property type="gene ID" value="lp_0108"/>
    </dbReference>
    <dbReference type="GeneID" id="57026950"/>
    <dbReference type="KEGG" id="lpl:lp_0108"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.88"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_9"/>
    <dbReference type="OMA" id="VMMAVYI"/>
    <dbReference type="PhylomeDB" id="F9UST3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-86-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441642" description="D/L-lactic acid transporter">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="9">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="9">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="25449" checksum="BD0119ABDCAF056D" modified="2011-10-19" version="1">MVHQLIAEFMGTALMIIFGVGVHCSSVLKGTKYRGSGHIFAITTWGFGISVALFIFGNVCINPAMVLAQCLLGNIAWSLFIPYSVAEVLGGVVGSVIVWIMYADHFKASTDEISPITIRNLFCTAPAVRNLPRNFFVELFDTFIFISGILAISEIKTPGIVPIGVGLLVWAIGMGLGGPTGFAMNLARDMGPRIAHAILPIANKADSDWQYGIIVPGIAPFVGAAIAAWFMHGFFGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU1</accession>
    <name>F9USU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein with HIRAN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2009-09" db="PDB data bank">
            <title>Crystal structure of protein lp_0118 from Lactobacillus plantarum,northeast structural genomics consortium target LpR91B.</title>
            <authorList>
                <person name="Seetharaman J."/>
                <person name="Lew S."/>
                <person name="Vorobiev S.M."/>
                <person name="Wang D."/>
                <person name="Janjua H."/>
                <person name="Cunningham K."/>
                <person name="Owens L."/>
                <person name="Xiao R."/>
                <person name="Liu J."/>
                <person name="Baran M.C."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 59-159</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100890.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3K2Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B/C/D=59-159"/>
    </dbReference>
    <dbReference type="PDBsum" id="3K2Y"/>
    <dbReference type="SMR" id="F9USU1"/>
    <dbReference type="STRING" id="220668.lp_0118"/>
    <dbReference type="DNASU" id="1061353"/>
    <dbReference type="EnsemblBacteria" id="CCC77672">
        <property type="protein sequence ID" value="CCC77672"/>
        <property type="gene ID" value="lp_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0118"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.96"/>
    <dbReference type="eggNOG" id="ENOG5030GSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518556_0_0_9"/>
    <dbReference type="OMA" id="HAVTYHE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-94-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIRAN" evidence="3">
        <location>
            <begin position="64"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3K2Y"/>
        </source>
    </evidence>
    <sequence length="530" mass="58972" checksum="C681934C59FC6330" modified="2011-10-19" version="1">MERIEAGMSVMTLKKQTYRVIAVINQGQELLVRAHEPETADIEIIPVTTVVQVTEQNSTGDAAVALDTVTVVGERYVDDIVATLTTLRVGMAVLLQRESGNQYDDNAISVWTLQHAKLGYIARYQNQPYATLMDQGQRLYGIVTVLDQQKQHLELMLWRTTAVPSPIEALQIRQRLAKPRTNLGAVPTHSLQTPLGTIVMMCNGHPIKYQQVPLSPWLTPADELHVTKRYLLTPDWSQVPPDSLITCQVTAKADVVQRWQNEHISAAVLTNASSFYVVGISAQTKTGLNDNLVDDAAQPAVIYRVGQVSAHMQAGFMVSWAPFGDPRVQPALKLALHFSSQPLVPYHPVTPSRTNATFTQQELAALLVSALPNYQGGQRLEPSVTTITVEKLRQTLGDQTYHALANYQRHVQLVAGSTEGVNETLLQALIHAVTYHELTTMHYYQPTVGMVDQVIYPIQLFSTTTKDEDDAQLVGCLALYNYETFEIQQVPLTAIARIAIIADPEHPQTTPETESPDWLRIFLHGWNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT09</accession>
    <name>F9UT09_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0202"/>
    <dbReference type="DNASU" id="1061428"/>
    <dbReference type="EnsemblBacteria" id="CCC77740">
        <property type="protein sequence ID" value="CCC77740"/>
        <property type="gene ID" value="lp_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0202"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.166"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_2_9"/>
    <dbReference type="OMA" id="RAVNFYH"/>
    <dbReference type="PhylomeDB" id="F9UT09"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-162-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16672" checksum="AE5C17CF94441726" modified="2011-10-19" version="1">MKIEHLQHPTTHQLDQLMTIWLSGNLTAHDFVSADYWRQQAPLVREALQSAELIVGLTDGPEAYILGFIGLQNDYIAGIFICNDAQHQGLGTALLATAQADYHQLQLNVYVANRPAIAFYHYHGFRVIDQASDQATQQSEYTMQWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT21</accession>
    <name>F9UT21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ISP2_1</name>
        <name evidence="8" type="ordered locus">lp_0216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100920.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77752">
        <property type="protein sequence ID" value="CCC77752"/>
        <property type="gene ID" value="lp_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0216"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.179"/>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9UT21"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-174-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="550" mass="64349" checksum="FA817111DF091F68" modified="2011-10-19" version="1">MQDYYNMNQTTLSIALDYQPEEHHSARYINQLVESLKLKYDYQFGRPREYNLGAMLKLVLLAYSYGIFSSRKIERFARENKPAGWLIADQIPSYRTICRFRISDELATLTTDSLSQLTQYLRQNGMIDDVSFIDGTKILADANKYSFVWKKNTIRFDKMNREKLVDLLGELHEAKIVGEIPAGSELTPELLDIMISKVEDHLVVLNETVEATKQVSPNPAKQQRRTVKSQKRKLDKRRDKMREHQAQQAIYDQRNSYSKTDHDATFMRVKEDPMQNGQLKPAYNVQIATSNQFITGYRLFQNPTDTRTLQPFIEHLKANNVLGHTIVADAGYGSESNYRYLEDEFGQHTVLIPYGTMLKENSRKWQSDDRKVMNWDYHEKDDYFINPQNVRFNFNAYRQRTDKYGFTRDFKEYIAEKYDENHQLISAALTPKGYLKRISVNENWEYFKSKQRELLSAPETGQIYAQRKIDVEPVFGKMKASLHFNRFSVRGFDKVTKEAGIVILALNIMKLVTVGTNFKNQRRKQMGRETKIRFLVPFAYTEASYVTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE0</accession>
    <name>F9UTE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, beta-glucosides-specific EIIABC component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts28ABC</name>
        <name evidence="16" type="ordered locus">lp_3240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102091.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890772.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3240"/>
    <dbReference type="EnsemblBacteria" id="CCC80258">
        <property type="protein sequence ID" value="CCC80258"/>
        <property type="gene ID" value="lp_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3240"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2706"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_10_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2746-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
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        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
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        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="573"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="288"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="664" mass="69699" checksum="42D8A7681ACD070A" modified="2011-10-19" version="1">MKQVHLLTPVAGQLVPLESVHDPVFSQGMMGQGFGIEPTDGQVVAPISGKVTMVAASLHAIGFTGNNGLEVLVHLGIDTVELADRPPFKVNVQVGDTVEAGEKVAMMDLAAITSANKDTTVIMAVTNTADMVTKLTPELGEVRAGVVGAVVELKEHVAEASVVKGKGGKYDELATQIIAQVGGPVNVKSVIHCITRVRFYLKDEGQANDEAIRNLKGVIDVAKAGGQYQVVIGPAVTDVYDAIVGQLGAGFGDADASAVAMEKEANRLAWQKMTPWQKVKHGFSSLIGVITGSMIPVIGLLAASGILKGILSLLKNFNLVSATTPTYVIINAMGDSVFYFLPIFVGFTAAKKLGADPVIMGIIGGVLTYPAIVGMATTGKVTGHLLGMAINANFFGIPVHVASYTYSIFPMIAGAWLASKLEPWLKRVIPTVLRMIFVPLFEVVIISGAIIIILGPIITALSGALAAGIVAIYKLSPAISGLIIGGFYQVLVIFGLHWAIIPIVVNDITTTGHSYLNAIVSATMVAQGGAVLAIALKSKFANIKELAWPATISAFCGVTEPAMYGINLKYGRAFITASIGGAVGGFLTGLFNVNMWGFAGSLIGVTSFINPKGLDFSFYGFLIASAIDLIVAFTLTWMFGFSDNDVKNVKKAPEKKHLGQQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ3</accession>
    <name>F9UTJ3_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, VanZ-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890825.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80311">
        <property type="protein sequence ID" value="CCC80311"/>
        <property type="gene ID" value="lp_3310"/>
    </dbReference>
    <dbReference type="GeneID" id="57026575"/>
    <dbReference type="KEGG" id="lpl:lp_3310"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2762"/>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077618_8_0_9"/>
    <dbReference type="OMA" id="ATFFIYL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2802-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="VanZ-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19919" checksum="8E0DF84618AA124C" modified="2011-10-19" version="1">MLAWLPFFLISLMFIVLLYACARSARTNIQRFKQLSLIAFLWVLTAFCYTPTSYNFGTQLVIQYIQWGPVKLNVIPFQQLDIEFWLNVLLTVPLGGLLAWNFPDLPWRRFIWLGFLTGLTLELGQFILDWLVNLKRWVDIDDVITNWAGVIIGAAGYKIARHVPGLRWLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ6</accession>
    <name>F9UTJ6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="11">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pflA</name>
        <name evidence="13" type="ordered locus">lp_3314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3314"/>
    <dbReference type="EnsemblBacteria" id="CCC80314">
        <property type="protein sequence ID" value="CCC80314"/>
        <property type="gene ID" value="lp_3314"/>
    </dbReference>
    <dbReference type="GeneID" id="57026578"/>
    <dbReference type="GeneID" id="66450842"/>
    <dbReference type="KEGG" id="lpl:lp_3314"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2765"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_1_1_9"/>
    <dbReference type="OMA" id="IGVPNKR"/>
    <dbReference type="PhylomeDB" id="F9UTJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2805-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="31319" checksum="37E53C897DCCAADE" modified="2011-10-19" version="1">MENKQVSTTQAAAKEPLIGYVHSIETFGSVDGPGIRYVAFLQGCHMRCQYCHNPDTWKLNVGDQMTADEILEDAAKYRAFWGKTGGITVSGGESLVQIDFILDLFEKAKAMNISTCLDTSGQPFTREQPFFDKFERLMKVTDISLVDIKHIDSAKHKQLTQYGNENILDMIQYMAQHHDDMWIRHVLVPQRTDYDEDLKKLGDYIAKIPNDVVQKVEVLPYHTLGVKKYHEMKIKYRLEGIESPTQDRVANAEKLLHTADYNGYKTWMPLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK6</accession>
    <name>F9UTK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ISP2_4N</name>
        <name evidence="8" type="ordered locus">lp_3331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890838.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3331"/>
    <dbReference type="EnsemblBacteria" id="CCC80324">
        <property type="protein sequence ID" value="CCC80324"/>
        <property type="gene ID" value="lp_3331"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3331"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2776"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="OMA" id="IRTHARC"/>
    <dbReference type="PhylomeDB" id="F9UTK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2815-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="461" mass="54120" checksum="EC5DADD999AE6D0A" modified="2011-10-19" version="1">MQDYYNMNQTTLSIALDYQPEEHHSARYINQLVESLKLNYDYQFGRPREYNLGAMLKLVLLAYSYGIFSSRKIERFARENKPAGWLIADQIPSYRTICRFRISDELATLTTDSLSQLTQYLRQNGMIDDVSFIDGTKILADANKYSFVWKKNTIRFDKMNREKLVDLLGELHEAKIVGEIPAGSELTPELLDIMISKVEDHLVVLNETVEATKQVSPNPAKQQRRTVKSQKRKLDKRRDKMREHQAQQAIYDQRNSYSKTDHDATFMRVKEDPMQNGQLKPAYNVQIATSNQFITGYRLFQNPTDTRTLQPFIEHLKANNVLGHTIVTDAGYGSESNYRYLEDEFGQHTVLIPYGTMLKENSRKWQSDDRKVMNWDYHEKDDYFINPQNVRFNFNAYRQRTDKYGFTRDFKEYIAEKYDENHQLIAAALTPKGYLKRISVNENWEYFKSKQRELLSAPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR6</accession>
    <name>F9UTR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641885.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888350.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0312"/>
    <dbReference type="EnsemblBacteria" id="CCC77836">
        <property type="protein sequence ID" value="CCC77836"/>
        <property type="gene ID" value="lp_0312"/>
    </dbReference>
    <dbReference type="GeneID" id="57027123"/>
    <dbReference type="GeneID" id="66448403"/>
    <dbReference type="KEGG" id="lpl:lp_0312"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.265"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_0_9"/>
    <dbReference type="OMA" id="MGFISRQ"/>
    <dbReference type="PhylomeDB" id="F9UTR6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-258-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="16081" checksum="05ABB2B1D83F9BFB" modified="2011-10-19" version="1">MIPTLRLMGTLSRIVTNEGNQRFAKYGLNNNQFIYLIRICEQPGLFFSQLADQMKMDRTTNYRAVQNLIKKGYVIKQTHPENKKVRCLYPTSAGQALYPELHAYEQWCADLVGEQLTPGQQQVLFESLSLVTANVTQHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT1</accession>
    <name>F9UTT1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acdH</name>
        <name evidence="3" type="ordered locus">lp_0329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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    </evidence>
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    </evidence>
    <sequence length="455" mass="48693" checksum="8FDA05AA40416111" modified="2011-10-19" version="1">MLKEMEETTVSRSIDRLVLNASLAANRLEVMDQSQVDQAVAAMARAAHAARGMLAAMAVEETGRGNYRDKVAKNDFAAKNVYNYIKDDKTVGIINDDPVSGVMKVAEPVGIIAGVTPVTNPTSTVIFNAMLALKTRNPIIFGFHPFAQKSCVETGRIIRDAAIASGAPKDWIQWIKTPSLEATNTLMNHPGVATIIATGGAGMVKTAYSTGKPALGVGPGNVPCFIEQTADIQQAVSDVVTSKSFDNGMICASESNLIVADQIYDQVKRELSHNGVYFVGTENFKALEATVMNLDKQAVDPKVAGQTPWQIAQWAGFDVPSDTKVLAVELPSIGGDQVLSREKLSPVLAVVHAKDTEAGFNLMKRSLALGGLGHTAALHTTDEAVMNKFALEMTACRALINVPSSQGAIGYKYDNVAPSLTLGCGTWGHNSISHNLEDWDLLNIKTVAKRLTKIR</sequence>
</entry>
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        <submittedName>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        </source>
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</entry>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888410.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0381"/>
    <dbReference type="EnsemblBacteria" id="CCC77896">
        <property type="protein sequence ID" value="CCC77896"/>
        <property type="gene ID" value="lp_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0381"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125499_0_0_9"/>
    <dbReference type="OMA" id="KYAITIN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-318-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="180" mass="20956" checksum="6B43BFAABC93888B" modified="2011-10-19" version="1">MKILNIFDAVRDGTFQDFKNFYEGNINVISGNLDLNLLCMAVTNDKNPEEKLQIIKFLFAEGIDVNYATQKEKRNALHLFYFCVLRPTIEYEMEITNLFIKHGVNVNATDKYNAIPLKYAITINNLPTSDNKEMYQLLLNKGSDYNLKDGFGKSCLDYAKEYSWRNDFLDIVKEYENSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY4</accession>
    <name>F9UTY4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thgA1</name>
        <name evidence="4" type="ordered locus">lp_0393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888418.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0393"/>
    <dbReference type="EnsemblBacteria" id="CCC77904">
        <property type="protein sequence ID" value="CCC77904"/>
        <property type="gene ID" value="lp_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0393"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.326"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_2_9"/>
    <dbReference type="OMA" id="KTYDHGK"/>
    <dbReference type="PhylomeDB" id="F9UTY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-327-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="205" mass="23105" checksum="36B6224952D412E6" modified="2011-10-19" version="1">MTNNNDRLHTGELYLPNDPELEKRQFGYLDQLYDFNQTRPSELTKRQILLSKMFAEIGPKCYIEPPFHSNFGGHHVHFGKGVYANFNLTLVDDTHIYVGDYTMFGPNVTIATAGHPILPSLREQAYQYNMPVHIGRNCWFGAGAIVLPGITIGDNVVVGAGSIVTKDLPDNVVAVGNPAHILRHINDHDRLYYFKDRQIDPSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU08</accession>
    <name>F9UU08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin peptide PlnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plnE</name>
        <name evidence="1" type="ordered locus">lp_0422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU08"/>
    <dbReference type="STRING" id="220668.lp_0422"/>
    <dbReference type="EnsemblBacteria" id="CCC77928">
        <property type="protein sequence ID" value="CCC77928"/>
        <property type="gene ID" value="lp_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="57024224"/>
    <dbReference type="GeneID" id="66448498"/>
    <dbReference type="KEGG" id="lpl:lp_0422"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.343"/>
    <dbReference type="eggNOG" id="ENOG5032CFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3044744_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-350-MON"/>
    <dbReference type="EvolutionaryTrace" id="F9UU08"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="56" mass="6191" checksum="45CEC1D5886A7738" modified="2011-12-14" version="1">MLQFEKLQYSRLPQKKLAKISGGFNRGGYNFGKSVRHVVDAIGSVAGIRGILKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU46</accession>
    <name>F9UU46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc/iron ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">znuB</name>
        <name evidence="8" type="ordered locus">lp_0464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0464"/>
    <dbReference type="EnsemblBacteria" id="CCC77966">
        <property type="protein sequence ID" value="CCC77966"/>
        <property type="gene ID" value="lp_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0464"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.383"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_1_0_9"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="PhylomeDB" id="F9UU46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-387-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="28484" checksum="29FC95B207CB92F4" modified="2011-10-19" version="1">MSMFSLVFMRNAYLAGTFIAIICGTIGVFVIARNLSFLTHTLSEIGFAGAAFGIFMGWTALSGMLIFTVISSVIVGQMSVKQSRREASISAISALFIGLGILFLSLSNQTSSYATSILFGSVIGIASADVIRVAILSAIVLLVMLGLYRPLKFDSFDAIGARVSGLWTTGISVVFLVLVAMSVSVAAQIVGSLLIFILLTLPAAAARYFVHTVSKMIFLAIGFALIGVWLGLYLSYVTNLPVSFFIAAIECIFYFAALGYQRLRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU55</accession>
    <name>F9UU55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890871.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3371"/>
    <dbReference type="EnsemblBacteria" id="CCC80357">
        <property type="protein sequence ID" value="CCC80357"/>
        <property type="gene ID" value="lp_3371"/>
    </dbReference>
    <dbReference type="GeneID" id="57026619"/>
    <dbReference type="KEGG" id="lpl:lp_3371"/>
    <dbReference type="eggNOG" id="ENOG5030AW1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2935818_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2845-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="60" mass="6668" checksum="CE5FCE146023CE3E" modified="2011-10-19" version="1">MELTIGLIIGTSIILAILCGILSIYYYHHTKKLNGTIWALIGIALLCLAGFFVWVVWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF1</accession>
    <name>F9UUF1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">melA</name>
        <name evidence="11" type="ordered locus">lp_3485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890967.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUF1"/>
    <dbReference type="STRING" id="220668.lp_3485"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80453">
        <property type="protein sequence ID" value="CCC80453"/>
        <property type="gene ID" value="lp_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3485"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2901"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_9"/>
    <dbReference type="OMA" id="WEGIYFD"/>
    <dbReference type="PhylomeDB" id="F9UUF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2941-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="10">
        <location>
            <begin position="37"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="9">
        <location>
            <begin position="657"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="738" mass="83632" checksum="26C519521A0A96CE" modified="2011-10-19" version="1">MAVTLQQTLIDIDEEQLVFHLHNDQISYILGVETGNVLAHLYFGPRVRGYHGERQYPRIDRGFSGNLPNTTDRSYSKDDLPQEYGGNNTGDYRQPAAIIRAANGARTVDFRYQDCRMEAGKPELKGLPQTYVEDEDEAQTLIVTLRDATLGVTLELAYTIYRDRPVITRSARLINHSEQAVDLEKVASMQMDLPTQPLDAISLPGSYARERQLSRERLHRGVTQFESRRGASSHHMNPFVALADPNTNEFQGNVLGALLIYSGNHQISLERDPIGQTRLTMGINEYNFDWRLAAGDSFQTPEVAMVYSTTGLNGMSQTYHDLLRDRVARSRYKHDLRPILINNWEATYFDFDADKIQSILDAAAPLGIEMFVLDDGWFGHRNDDNSSLGDWFVNRNKLPGGLADISKRTHDKGMRFGLWFEPENISADSDLYRAHPDWVLGVPDRGRTLSRNEYVLDFSQPDVVDNIFEQMTAVLDKVPIDYIKWDMNRNLTEVYSPHSDSTHEGETSHRFILGVYDLMERLTKRYPQILFEGCSGGGGRFDAGLMYYMPQSWPSDNNDPIERLKIQYGTSLVYPISAITAHVGTSPDELLGRSTSMKMRGAVAMSGTLGYELDAAQLSDADKQAVKRQVAFYKQHRELVQYGTFYRLESPFESNTVAWMFVSPDQKEALLFTFVILGAVQPEPHITKLAGLDPQQTYVETDTNKMYGGDELMQLGLYTTPVQTSDFTAQVHYFKAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH2</accession>
    <name>F9UUH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3506"/>
    <dbReference type="DNASU" id="1062838"/>
    <dbReference type="EnsemblBacteria" id="CCC80474">
        <property type="protein sequence ID" value="CCC80474"/>
        <property type="gene ID" value="lp_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3506"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2922"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_4_3_9"/>
    <dbReference type="OMA" id="ILNGHYH"/>
    <dbReference type="PhylomeDB" id="F9UUH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2962-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="243" mass="28215" checksum="7E05DA065D42B3D5" modified="2011-10-19" version="1">MSRKEPIYQTILSALILELNTNHFRKNDPFYSESELRKKYQVSSTTVVRVLNMLADQGYIYRIQGKGSFVSKFNRGTAVRITDTHTYDVDEEQVAILVANQTTPLPTRAKFTAESTTWYLERLREIRHAPFEFSQSWYLATLIPATAMKKLRAVHSIYALIRKHAQLDLSRQPFEQEYAATCVPNQRIADYLHVSLDTMVIKIERWVFQGEETLEYTVSYMLPNYFGLALTSDSKSVDPNRIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-11" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>P77885</accession>
    <accession>F9URI3</accession>
    <name>CARA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Carbamoyl-phosphate synthase pyrimidine-specific small chain</fullName>
            <ecNumber>6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbamoyl-phosphate synthetase glutamine chain</fullName>
            <shortName>CPS-P</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrAA</name>
        <name type="ordered locus">lp_2701</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3416" last="3422">
            <title>In Lactobacillus plantarum, carbamoyl phosphate is synthesized by two carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the arginine-repressed from the pyrimidine-regulated CPS.</title>
            <authorList>
                <person name="Nicoloff H."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
            <dbReference type="PubMed" id="10852872"/>
            <dbReference type="DOI" id="10.1128/JB.182.12.3416-3422.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text>Inhibited by pyrimidine.</text>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text>Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890336.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77885"/>
    <dbReference type="SMR" id="P77885"/>
    <dbReference type="STRING" id="220668.lp_2701"/>
    <dbReference type="MEROPS" id="C26.963"/>
    <dbReference type="EnsemblBacteria" id="CCC79822">
        <property type="protein sequence ID" value="CCC79822"/>
        <property type="gene ID" value="lp_2701"/>
    </dbReference>
    <dbReference type="GeneID" id="66450359"/>
    <dbReference type="KEGG" id="lpl:lp_2701"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2261"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_9"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="PhylomeDB" id="P77885"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2313-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000112286" description="Carbamoyl-phosphate synthase pyrimidine-specific small chain">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1">
        <location>
            <begin position="169"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91004." evidence="2" ref="1">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="364" mass="39983" checksum="5B916580EE4C3267" modified="2003-03-25" version="2">MKRYLVLEDGTIYPGTGFGATTATVGELVFNTGMSGYQESITDQSYNGEILMFTYPLIGNYGINRDDHESIKPTCKGVVVHEVARRASNWRNAQSLDDYLKQNAIPGIMDIDTRAVTKHIRTKGAMKATIVDNVLPDTVDRLKVTELNRAVVAQSSTNNAYPNPATGPNVVVVDFGLKHSILRELAKRQCNLTVLPYNTTASEIMALNPDGVMLTNGPGDPKDVPGALEMIREVEKHVPLFGICLGHQLFALANGADTFKMKFGHRGFNHPVREIATGRIDFTSQNHGYAVDRDSLAQTDLLITHEEINDGTVEGLRHRDYAAFSVQYHPDAAPGPHDADHIFDEFIDLMAANQATQKGSQFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD4</accession>
    <name>Q6LWD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tnpA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222049.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133757.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723593"/>
    <dbReference type="EnsemblBacteria" id="CAG17874">
        <property type="protein sequence ID" value="CAG17874"/>
        <property type="gene ID" value="CAG17874"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17874"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3119"/>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009098_14_1_9"/>
    <dbReference type="OMA" id="YPHAMRT"/>
    <dbReference type="PhylomeDB" id="Q6LWD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3174-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF4158" evidence="7">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="586"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG17874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="997" mass="114147" checksum="5E4E15F9E420897B" modified="2004-07-05" version="1">MPTNPHHQQSFGTFEGVPSADQLRLYFQLTDFDRALIDEMRSATTKLGFAVQLSSVRFLGTFPTNLQQVPAEVIDYLAKQLTIDGRALAGYTRKMTISQHMTLIKRKYHYQAFTDPAVKASLNDWLLERARFTTETEKLLFDMLLKKCLDEKILLPGVTTFERFINGVTEVAADLLDSQLVAVPSVEETDRLLNLLTAVGEPIYGATIKMDLLRNPLMDESRKEINRGFTRLKQFQQFKTEDWQLGAIPAGKLKNLANYAFKAKASLIKRMSVKRQTALLVAFVSEYRKRAMDEQLLALSRFYETLFKRAKKKEAKERLRTIKDLDHAALTLSQIVRLLMDETISSQDLRNKVLATYPPEIIESAVTQVNQLVRNEREPIAIEELLNAYRKFRKFIPDILATIVFEGTINGQDCLIVWEFIRQRFPRPVTYRMFEQIAEKLPKKWRYYIRENPKVTNQCVLIAGIELLVHGLKRHDIYVRQSNRYLDPMACLIDKSTWRQQKAVLIQQLDLPQTGQAAVEAVKQDLALSYAETLKNWADSEMAQVKEVDGQEKIIVAKLRKAREQKDEAAFKSRVRHLIPKIDLSDILLEVNQQLQLTQCFSHVSESETKMKHVDISILAVLLAEACNIGLSPVAKNSSNSLKYDRLMYVDHQYLRIDTLAAANRRIINAHKKLKSALIWGDGQMASADGIRYVTPQRSLYSRSNPKYFGRGRGITFYNFVSDQYIGFHGMVVAGTLRDSLYLLEGFLNQGSSLEPTQIMTDTAGYSDLVFGLFGLLGFQFSPRIANSQGTKLWRIDSTADYQVLNGVSQNRINLKLIEEHWEDILRVAGSLKSGKVNATELTQALQREGHPTALGKAITEYGKVYKTKHQLRYLSDELYARQILEQLNKGEARHALCRNIFYGRKGKLYQTYFDGMEEQLNALSLVTNAIIYWNTVYLEKIVTQMQSEGFDCSDDMIGKLSPLMFEHINFVGKYTFQYNEALENGHLRPLDEADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF6</accession>
    <name>Q6LWF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf21</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222028.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133735.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723571"/>
    <dbReference type="EnsemblBacteria" id="CAG17852">
        <property type="protein sequence ID" value="CAG17852"/>
        <property type="gene ID" value="CAG17852"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17852"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3099"/>
    <dbReference type="eggNOG" id="ENOG5030A6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202494_0_0_9"/>
    <dbReference type="OMA" id="YQVAWQK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3152-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="71" mass="7887" checksum="2183B41A2C038B0A" modified="2004-07-05" version="1">MDNELTVIGSELPVLQTKGTYKYLKEITGNGSYYQVAWQKLADGYVALYGTTPVQINVAPILNDIFEDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG2</accession>
    <name>Q6LWG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Repressor of arsenical resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arsD2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003678452.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133729.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723565"/>
    <dbReference type="EnsemblBacteria" id="CAG17846">
        <property type="protein sequence ID" value="CAG17846"/>
        <property type="gene ID" value="CAG17846"/>
    </dbReference>
    <dbReference type="GeneID" id="39466530"/>
    <dbReference type="KEGG" id="lpl:CAG17846"/>
    <dbReference type="eggNOG" id="ENOG5032RMG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120868_1_0_9"/>
    <dbReference type="PhylomeDB" id="Q6LWG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3146-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010712">
        <property type="entry name" value="Arsenical-R_ArsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06953">
        <property type="entry name" value="ArsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="99" mass="11350" checksum="01117EF73EF57089" modified="2004-07-05" version="1">MCCATGVCGPSVKKELIQTTAIQRHVNADGENIIIRRNLTQNPDAFVRNHQINDLLKKYGITVLPITMVNGIIFKQRDYPTFQEFSDYLHQDLSRAFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH9</accession>
    <name>Q6LWH9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS102</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377165">
        <property type="protein sequence ID" value="CAG17829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222009.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133713.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17829">
        <property type="protein sequence ID" value="CAG17829"/>
        <property type="gene ID" value="CAG17829"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17829"/>
    <dbReference type="HOGENOM" id="CLU_1775076_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3130-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS102"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="17103" checksum="C47A3CC609A70E72" modified="2004-07-05" version="1">MVGGILGLVGVTITLFYSFFNDKRSKKFQLQLESDNENFQNTLAIQEHERRIWMKKYEVLVQLIGSRYDFSSTEFKRAFNSVPAVFFDSPDVIKSYKNFYSYKSNSSVDDGLANEKLVNIFVEMYRDLEIEENVDETDLEKIFDTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RZ2</accession>
    <accession>F9ULK6</accession>
    <name>RBSD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-ribose pyranase</fullName>
            <ecNumber evidence="1">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbsD</name>
        <name type="ordered locus">lp_3659</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891127.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RZ2"/>
    <dbReference type="SMR" id="Q88RZ2"/>
    <dbReference type="STRING" id="220668.lp_3659"/>
    <dbReference type="EnsemblBacteria" id="CCC80613">
        <property type="protein sequence ID" value="CCC80613"/>
        <property type="gene ID" value="lp_3659"/>
    </dbReference>
    <dbReference type="GeneID" id="57026839"/>
    <dbReference type="GeneID" id="66451086"/>
    <dbReference type="KEGG" id="lpl:lp_3659"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3057"/>
    <dbReference type="eggNOG" id="COG1869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135498_0_0_9"/>
    <dbReference type="OMA" id="IIRTGEC"/>
    <dbReference type="PhylomeDB" id="Q88RZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3100-MON"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000346220" description="D-ribose pyranase">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <sequence length="131" mass="14637" checksum="916D98B6F4AF5656" modified="2003-06-01" version="1">MKKTKVINSDLSRVIATMGHFDKLSIGDAGMPVPSSTEKIDLAVDNGIPSFMQVLNNVLEELEVQRIYLAEEIKVQNPKMLTAIKKRLPDTPITFIPHEEMKKDLADCKAFVRTGEMTPYSNILLESGVTF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V12</accession>
    <accession>F9UQJ4</accession>
    <name>Y2275_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0297 protein lp_2275</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2275</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0297 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641523.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889997.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V12"/>
    <dbReference type="SMR" id="Q88V12"/>
    <dbReference type="STRING" id="220668.lp_2275"/>
    <dbReference type="EnsemblBacteria" id="CCC79483">
        <property type="protein sequence ID" value="CCC79483"/>
        <property type="gene ID" value="lp_2275"/>
    </dbReference>
    <dbReference type="GeneID" id="57025820"/>
    <dbReference type="GeneID" id="66450032"/>
    <dbReference type="KEGG" id="lpl:lp_2275"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1926"/>
    <dbReference type="eggNOG" id="COG4472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162466_0_0_9"/>
    <dbReference type="OMA" id="IMSGDPT"/>
    <dbReference type="PhylomeDB" id="Q88V12"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1968-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01507">
        <property type="entry name" value="UPF0297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037258">
        <property type="entry name" value="DUF965_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000216971" description="UPF0297 protein lp_2275">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01507"/>
        </source>
    </evidence>
    <sequence length="89" mass="10296" checksum="F6007CCE826CEF4E" modified="2003-06-01" version="1">MSSLDKTMYFDFDNDSVKDVHDTLTTVYEALQEKGYNPINQIVGYLLSGDPAYIPRLKDARNLIRKHQRDEIIEELVKSYLKADKDVDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VE1</accession>
    <accession>F9UQ64</accession>
    <name>TIG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">lp_2118</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889867.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VE1"/>
    <dbReference type="SMR" id="Q88VE1"/>
    <dbReference type="STRING" id="220668.lp_2118"/>
    <dbReference type="EnsemblBacteria" id="CCC79353">
        <property type="protein sequence ID" value="CCC79353"/>
        <property type="gene ID" value="lp_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2118"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1794"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_2_9"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="PhylomeDB" id="Q88VE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1814-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000179368" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="440" mass="49436" checksum="55EBECD47A5CB435" modified="2003-06-01" version="1">MAAKWEKKEGNQGELTFEIGADKISEGIDKAFQRTKKNLNVPGFRKGKVPRQIFNQMYGEEALYQDALNIVLPEAYEEAIKETEIEPVDQPQIDVDSMEKGKPWVLKAVVTVKPEVKLGQYKELSVTRQNTRVYAKDVDAELESRREKQAELVLKEDQPAAKGDTVVIDFKGFVDGEPFEGGESENYSLELGSNSFIPGFEDQLVGVKAGDETEVKVTFPKDYQAEDLQDKEATFKVTVHEVKTKELPELDDEFAKDVDEDVDTLEELKAKIKDELKEQKESAAHDAIEDEALNQAVDNAEIQAIPDAMKEDDIHRQMDQYLANMQQQGIDPKTYYKLTGTTEDDLHKQFAADAERRVKTNLVLEAVVEAENIKPSQDEIAAEVKDLASQYNMEESAVRGALTDDMLSHDIAIRQAVDLIADSAKQNAKAEDKKDDSDKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VE2</accession>
    <accession>F9UQ63</accession>
    <name>CLPX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">lp_2116</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889866.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VE2"/>
    <dbReference type="SMR" id="Q88VE2"/>
    <dbReference type="STRING" id="220668.lp_2116"/>
    <dbReference type="PRIDE" id="Q88VE2"/>
    <dbReference type="EnsemblBacteria" id="CCC79352">
        <property type="protein sequence ID" value="CCC79352"/>
        <property type="gene ID" value="lp_2116"/>
    </dbReference>
    <dbReference type="GeneID" id="57025658"/>
    <dbReference type="GeneID" id="66449887"/>
    <dbReference type="KEGG" id="lpl:lp_2116"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1793"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_9"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="PhylomeDB" id="Q88VE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1813-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160371" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="421" mass="46519" checksum="1ADD020F36EE0739" modified="2003-06-01" version="1">MFENTETNGPVNCSFCGKSQDQVKKIVAGPGVYICNECIDLCKEIIDEEFSEEQTHELTDIPTPKEIVDELDQYVIGQNEAKRTLSVAVYNHYKRVKAMADNDEETEDGPELQKSNISLVGPTGSGKTFLAQSLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQNADYDVERAEKGIIYIDEIDKIAKKSENVSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPQQEFIQIDTTNILFIVGGAFDGIEDIVKRRLGDKTIGFGTDTDGKNAVLDDSKSLMQQVVPEDLLQFGLIPEFIGRLPILTALERLTEDDLVRILTEPKNALVKQYQRLIALDGAELDFNDDALRAIAQEALARNTGARGLRSIIEDTMRDIMYDIPSREDVKKVIITRETVADHAEPELVLADQKAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-03" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VK2</accession>
    <accession>F9UQ02</accession>
    <name>DPO3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III PolC-type</fullName>
            <shortName evidence="1">PolIII</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">polC</name>
        <name type="ordered locus">lp_2045</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889805.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VK2"/>
    <dbReference type="SMR" id="Q88VK2"/>
    <dbReference type="STRING" id="220668.lp_2045"/>
    <dbReference type="PRIDE" id="Q88VK2"/>
    <dbReference type="EnsemblBacteria" id="CCC79291">
        <property type="protein sequence ID" value="CCC79291"/>
        <property type="gene ID" value="lp_2045"/>
    </dbReference>
    <dbReference type="GeneID" id="57025597"/>
    <dbReference type="KEGG" id="lpl:lp_2045"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1730"/>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003297_0_0_9"/>
    <dbReference type="OMA" id="YYAAYFT"/>
    <dbReference type="PhylomeDB" id="Q88VK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1752-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024754">
        <property type="entry name" value="DNA_PolC-like_N_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028112">
        <property type="entry name" value="DNA_PolC-type_N_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14480">
        <property type="entry name" value="DNA_pol3_a_NI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11490">
        <property type="entry name" value="DNA_pol3_a_NII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000204578" description="DNA polymerase III PolC-type">
        <location>
            <begin position="1"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease">
        <location>
            <begin position="422"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1437" mass="162045" checksum="EA6A81D70788D952" modified="2003-06-01" version="1">MSLNQQEMFEKLLEQIEMPTGPEFTEAAIDKLTVHQASKVWEFHLHFQHVLPYTQFMTFQNKLQIAFKEIARVTFTIVTDDTEVNGRELAEYWEWIVQHSGIKSPLVQSLCNSNVPTYEDGRVILLAENEVIQNFLTNQALGPIESTYHRLGFPKFSVHTMIDESASQAKIKEFHEQKAKSDQALAQKAEAAIKKANEKRQKQADAPAPIDGPVQLGKQINPQEPAKQMVQITEEERSVVVEGYVFDMEVRTLRSQRQLLILKVTDYSSSMVVKKFSRNADDEAQFAALKPGMWVRVRGSVQEDSFMRDLTINAYDINETSHASRQDTAPADEKRVELHLHSNMSQMDATNSVSDYVKQAAKWGHPAIAITDHSGAQAFPEAFAAGEKNNIKILYGVEANMVDDGVPIAYNDAHVDLKESTYVIFDTETTGLSAIYDRVIELSAVKMVKGNVVDQFEEFIDPGFHLSETTTNLTSITDDMVRGSKSEEEVFKLFREFYGDAIVVGHNVTFDIGFMNTGYARHHMGPITNPIIDTLTLARWLYPNLRGYRLNTLAKKFNVNLEHHHRAIYDAETTGHLNHLFLKDAEDRYQVQFHDQLNDHMNENAAYRHARPFHATLYAQTQAGLKNLFRIISLSNVEYYYRVPRVPRSVLNKYRDGILVGSACSSGEVFTAMMQKGKEEARQKAGYYDFLEVQPKPAYSALIESGLIADTDHLEEIISNMVELGHEMNIPVAATGDVHYLNPEDKIYRKILIHSQPGNPLNRTERPDVHFRSTDEMLKDFDFLGTETAHEVVVDTPRALADQFEIVRPVKDKLYTPRMKGAEAEIEKLTMDRAHAWYGNPLPEIVQKRVDKELKSIIGNGFSVIYLIAQRLVFKSNKDGYLVGSRGSVGSSIVATLSGITEVNPMPPHYRCPNCQYSHFYTNNEYGSGYDLPPKDCPECGTDMVRDGQNIPFETFLGFYGNKVPDIDLNFSGDYQPIAHNYTKVLFGEKNVYRAGTIGTVADKTGYGYVKAYERDTNQTLRSAEVDRLAKGTTGVKRTTGQHPAGIIVVPDYMDIYDFTPVQYPADDQSAAWQTTHFDFHSIHDNILKIDILGHDDPTMIRMLQDLSGVQPESIPPVDPHVMKIFSSPEVLGVTEDQIFSKTGTLGIPEFGTRFVRGMLEETHPSTFNELLQISGLSHGTDVWLGNAEELIKDGTVTLAEVIGCRDNIMTDLIHYGMESDMSFQIMEHVRKGRGIPDEWQQAMKDANVPDWYIESCLKIKYMFPRAHAAAYILMALRVAYFKVYFPLIYYTAYFSVRADDFDLVAMAHGKDAVKASMKAITDKGMDASAKEKNLLTVLELANEMLERGFKFSMVDLDKSDASDWLIDGDTLIAPFRAVPGLGLNVAKQIVAARADKPFLSKEDLSKRGKVSKSLIDFMTENGVLSDLPDENQLSLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W23</accession>
    <accession>F9UPI2</accession>
    <name>TRMFO_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="1">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmFO</name>
        <name type="synonym">gid</name>
        <name type="synonym">gidC</name>
        <name type="ordered locus">lp_1848</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W23"/>
    <dbReference type="SMR" id="Q88W23"/>
    <dbReference type="STRING" id="220668.lp_1848"/>
    <dbReference type="EnsemblBacteria" id="CCC79121">
        <property type="protein sequence ID" value="CCC79121"/>
        <property type="gene ID" value="lp_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1848"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1558"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_9"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="PhylomeDB" id="Q88W23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1584-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117248" description="Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <sequence length="441" mass="48261" checksum="0D1B4E9B6DEDF78D" modified="2003-06-01" version="1">MASIPTVNVIGAGLAGSEAAWHIANMGVNVRLYEMRPNKMTPAHHTAQFAELVCTNSLRANQLANAAGLLKAEMRQMDSIVMQAAEHHAVPAGGALAVDRDTFSAEITAAITALPNVEIINEEITSLPDGITVVATGPLTAASLAKSIQAFNDEDDLHFFDAAAPILTKDSIDMDKVYLKSRYDRGEAAYLNCPMTEAEFDVFYDALIHAEMAEAHDFENSDVFEGCMPIEVMAQRGRQTMLFGPLKPVGLEDPKTGKQPFAVVQLRQDDAAGDLYNIVGFQTHLKWGEQKRVFSLIPGLENVEFVRYGVMHRNTFMKSPKLLTPTYQTQQRPDLFFAGQMTGVEGYIESAASGIVAGTNAARLALGLEPVVFPTDTMMGAMAHYITHTSASNFQPMNANFGIMPKLKQRIRDKRERNTAISERALADLTTFKDETLTVNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YN5</accession>
    <accession>F9ULU9</accession>
    <name>PHNC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphonates import ATP-binding protein PhnC</fullName>
            <ecNumber evidence="1">7.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnC</name>
        <name type="ordered locus">lp_0714</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)</text>
            <dbReference type="Rhea" id="RHEA:18065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16215"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888702.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YN5"/>
    <dbReference type="SMR" id="Q88YN5"/>
    <dbReference type="STRING" id="220668.lp_0714"/>
    <dbReference type="PRIDE" id="Q88YN5"/>
    <dbReference type="EnsemblBacteria" id="CCC78188">
        <property type="protein sequence ID" value="CCC78188"/>
        <property type="gene ID" value="lp_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="57024423"/>
    <dbReference type="KEGG" id="lpl:lp_0714"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.601"/>
    <dbReference type="eggNOG" id="COG3638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="GWAHRLV"/>
    <dbReference type="PhylomeDB" id="Q88YN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-623-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51249">
        <property type="entry name" value="PHNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0918">Phosphonate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092712" description="Phosphonates import ATP-binding protein PhnC">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01713"/>
        </source>
    </evidence>
    <sequence length="256" mass="28117" checksum="FAAF01AB71602A31" modified="2003-06-01" version="1">MLKVIQLDKTYGSNKHSLKAVNFTAKPGEVTAIIGPSGAGKTTILRSINQLIRDDSGQILLDDTDIRQANKAELRKVRHHIGMIFQNYNLISPLTALENVLHGRLGAKSTVAGMLGLYSSAEKQEALQLLDEVGLKEYAYQRCDQLSGGQQQRVGIARALMQHPKMILCDEPIASLDPKSTTIVMDILRRLAKEKQLIILINLHQVDIAMAYTDHIVGINSGAIVFEGATNEVDDAVLQHIYRQPDQSTAVAANEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL08</accession>
    <name>F9UL08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein, QueT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888537.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0533"/>
    <dbReference type="EnsemblBacteria" id="CCC78023">
        <property type="protein sequence ID" value="CCC78023"/>
        <property type="gene ID" value="lp_0533"/>
    </dbReference>
    <dbReference type="GeneID" id="66448582"/>
    <dbReference type="KEGG" id="lpl:lp_0533"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.441"/>
    <dbReference type="eggNOG" id="COG4708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104115_1_0_9"/>
    <dbReference type="OMA" id="APIMYAV"/>
    <dbReference type="PhylomeDB" id="F9UL08"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-444-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="18487" checksum="3FDDA8146E8CE186" modified="2011-10-19" version="1">MTQSKIRPWIINALVAAMYVVLCLGPAAFSLASGAIQFRVSEGLNHLAVFNRKYIWGIVAGVILFDAFGPGASLLNVLFGGGQSLLALLVLTWLAPKLKTVWQRMLLNIALFTVSMFMIALMITMMSSGVAFWPTYLTTALSELIIMSITAPIMYSLDRVLHFSDRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL22</accession>
    <name>F9UL22_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dus2</name>
        <name evidence="13" type="ordered locus">lp_0549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0549"/>
    <dbReference type="EnsemblBacteria" id="CCC78037">
        <property type="protein sequence ID" value="CCC78037"/>
        <property type="gene ID" value="lp_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="57024323"/>
    <dbReference type="KEGG" id="lpl:lp_0549"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.455"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_9"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="PhylomeDB" id="F9UL22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-458-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="335" mass="36799" checksum="55F6CA2D491C14C7" modified="2011-10-19" version="1">MNQEWQIGDVTIPNRVVVAPMAGVTNAAFRVICKDFGAGLVVCEMISDRGIMYHNRKTLEMMFVDPKEHPMSIQIFGGSKATLVQAAQFVDQQTNADIIDINMGCPVNKVVKTDAGAKWLLSPDKVYEMVAAVTAAVNKPVTVKMRTGWDAEHVYAVENARAAERAGAAAVAMHGRTRKQMYQGHADWDVLKRVADALTIPLMGNGDVQTPQDAARMLDEVGADAVMIGRAVEGNPWMLTQTVHYLATGELLTPPTPMAKMQTAMEHLQRLVVLKGERGGCHEFREQAPYYLKGIPRSARTKVALMEASSLAEMMRILTQFQEQTATYLASHAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA3</accession>
    <name>F9ULA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888632.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0640"/>
    <dbReference type="EnsemblBacteria" id="CCC78118">
        <property type="protein sequence ID" value="CCC78118"/>
        <property type="gene ID" value="lp_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0640"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.534"/>
    <dbReference type="eggNOG" id="ENOG5030B4U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1956806_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-551-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14992" checksum="5135FA9D84F51D7D" modified="2011-10-19" version="1">MIPAQAGLNEHWQQRNDSRDWVLDADNYCYDGDEFDKAQLFQDYIDNNDFEQWATDMQADMLSAICIVTFGSTDVSVLYPDQGEEPNWQWLIDVFGQSRLWDELLVHIDTDTMMTRLGYHWVSEGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC4</accession>
    <name>F9ULC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891045.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3569"/>
    <dbReference type="EnsemblBacteria" id="CCC80531">
        <property type="protein sequence ID" value="CCC80531"/>
        <property type="gene ID" value="lp_3569"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3569"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2978"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_9_1_9"/>
    <dbReference type="OMA" id="FGRIKDW"/>
    <dbReference type="PhylomeDB" id="F9ULC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3019-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="143" mass="16164" checksum="8D94034124A666EB" modified="2011-10-19" version="1">MVENQAIGLSRGGRTTKIHALVDGLGNPLGFRLTGGQVHDSQVASELLEGFDISQSNIIADKAYGTAKLRQYIEDKAGVYTIPPKENTKDKWTCDYHVYCERHLIENFFNQLKNFRRIATRYDKLAHVYLATVYIASICILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT1</accession>
    <name>F9ULT1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdH</name>
        <name evidence="5" type="ordered locus">lp_0694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0694"/>
    <dbReference type="EnsemblBacteria" id="CCC78170">
        <property type="protein sequence ID" value="CCC78170"/>
        <property type="gene ID" value="lp_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="57024404"/>
    <dbReference type="GeneID" id="66448672"/>
    <dbReference type="KEGG" id="lpl:lp_0694"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.583"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_9_0_9"/>
    <dbReference type="OMA" id="PACVQCD"/>
    <dbReference type="PhylomeDB" id="F9ULT1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-604-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="8633" checksum="960A2D18741FAEC8" modified="2011-10-19" version="1">MKKVTVFTKNNCMQCKMTKKFLTAHNIAFEEKNINTNPEYVDYLKNQGFHAVPVVEINGEDSIAGFRPDALKQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULU3</accession>
    <name>F9ULU3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2007-02" db="PDB data bank">
            <title>Crystal structure of oleoyl thioesterase (putative) (NP_784467.1) from Lactobacillus plantarum at 2.00 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888696.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2OWN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-261"/>
    </dbReference>
    <dbReference type="PDBsum" id="2OWN"/>
    <dbReference type="SMR" id="F9ULU3"/>
    <dbReference type="STRING" id="220668.lp_0708"/>
    <dbReference type="DNASU" id="1062819"/>
    <dbReference type="EnsemblBacteria" id="CCC78182">
        <property type="protein sequence ID" value="CCC78182"/>
        <property type="gene ID" value="lp_0708"/>
    </dbReference>
    <dbReference type="GeneID" id="57024417"/>
    <dbReference type="KEGG" id="lpl:lp_0708"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.595"/>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045466_2_0_9"/>
    <dbReference type="OMA" id="NKYFCYR"/>
    <dbReference type="PhylomeDB" id="F9ULU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-617-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016295">
        <property type="term" value="F:myristoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004320">
        <property type="term" value="F:oleoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016296">
        <property type="term" value="F:palmitoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="2OWN"/>
        </source>
    </evidence>
    <sequence length="261" mass="29919" checksum="7B4ED275B11188F8" modified="2011-10-19" version="1">MATLGANASLYSEQHRITYYECDRTGRATLTTLIDIAVLASEDQSDALGLTTEMVQSHGVGWVVTQYAIDITRMPRQDEVVTIAVRGSAYNPYFAYREFWIRDADGQQLAYITSIWVMMSQTTRRIVKILPELVAPYQSEVVKRIPRLPRPISFEATDTTITKPYHVRFFDIDPNRHVNNAHYFDWLVDTLPATFLLQHDLVHVDVRYENEVKYGQTVTAHANILPSEVADQVTTSHLIEVDDEKCCEVTIQWRTLPEPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW0</accession>
    <name>F9ULW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888713.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9ULW0"/>
    <dbReference type="STRING" id="220668.lp_0729"/>
    <dbReference type="EnsemblBacteria" id="CCC78199">
        <property type="protein sequence ID" value="CCC78199"/>
        <property type="gene ID" value="lp_0729"/>
    </dbReference>
    <dbReference type="GeneID" id="57024434"/>
    <dbReference type="KEGG" id="lpl:lp_0729"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.614"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_1_9"/>
    <dbReference type="OMA" id="VGHWYEH"/>
    <dbReference type="PhylomeDB" id="F9ULW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-634-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="611" mass="67277" checksum="21C906DDF7501DF7" modified="2011-10-19" version="1">MWRYLKRLVIGKPLKTMDEGGQALTKFKALALLSSDALSSVAYGTEQITTVLITLSAAALMYQLYVAALVLVLLFAITMSYRQIIRAYPSGGGAYVVASTNWGRPAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALANYQVLIAVLIVIAIMALNLRGMRESASFLTFPVYFFIIMIIGMILWGVMNIASGNLTYHASAAVGAPVQGMTLVLFLRAFSSGSSSLTGVEAISNAVPNFKRPKRKNAANTLAIMSLVLAVFFGGITYLSYYLGVKPQVDNTVLSQIATAVFGHGLFYYLLQLSTALILAVAANTGFSAFPILAYNLAKDKFLPHAYMDRGDRLGYSNGIISLAVGAIALIFIFHGKTTLLIPLYAVGVFVPFTLSQSGMIIHWFRERGQWWWMKAAVNLLGALISILLVIFLFLLHFGNVWPYLIVMPLLLYMFYRIHVHYNRVAAQLRVVAKEKAAIHDYDGATVIVLVSNVTRVTAQAVNYARSIGDYVIAMHVSFDENPEKEHKTAAEFKETFPDVRFVDIHSSYRSIATPTLRFCDVIAKRAAERNFSTTVLVPQFVPKKPWQNILHNQTSLRLRAVLNSRENIIVSTYNYHLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY7</accession>
    <name>F9ULY7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trxB</name>
        <name evidence="11" type="ordered locus">lp_0761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0761"/>
    <dbReference type="EnsemblBacteria" id="CCC78226">
        <property type="protein sequence ID" value="CCC78226"/>
        <property type="gene ID" value="lp_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="57024467"/>
    <dbReference type="KEGG" id="lpl:lp_0761"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.642"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_9"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="PhylomeDB" id="F9ULY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-661-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="33455" checksum="BF013DD361ED8343" modified="2011-10-19" version="1">MAKSYDVIIIGAGPAGMTAALYASRANLSVLLLDRGIYGGQMNNTAAIENYPGFKSVLGPDLAKDMYESATQFGAEYAYGSVESVEDRGDVKIVTTDSDTFETKALVIGTGSEYRKLGVTGEDTYGGRGVSYCAVCDGAFFRNKHVVVVGGGDSAIEEGTYLTQLADKVTVIHRRDQLRAQQILQDRAFANPKMEFVWNSNVTEIIGDDKKVTGVKVNNNKTGEDSEIAVDGVFIYVGINPITKPFSNLGITDENGWIETNDHMETKVPGIFAVGDVRKKDLRQVATAVGEGGTAGQGVYTYITALGDKVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ0</accession>
    <name>F9ULZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgm</name>
        <name evidence="11" type="ordered locus">lp_0764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0764"/>
    <dbReference type="EnsemblBacteria" id="CCC78229">
        <property type="protein sequence ID" value="CCC78229"/>
        <property type="gene ID" value="lp_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="57024470"/>
    <dbReference type="KEGG" id="lpl:lp_0764"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.645"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_9"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="PhylomeDB" id="F9ULZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-664-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="211"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="326"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="575" mass="63537" checksum="2FF36D45E19635AA" modified="2011-10-19" version="1">MSWQDTYNTWKNQATLETSLKQELTGMAGDDAALEDAFYEPMEFGTAGMRGVLGPGINRMNIYTVRQATEGLARFMDTLPAEVKERGVAISFDSRHHSEDFAHESARVLGQHGIKSYVFESLRPTPELSFTVRHLHTYAGIMITASHNPKQYNGYKIYGEDGGQMPPKESDLITSYIRKVDDVFAIAVADEQQLLADKTETIIGDDVDQDYLAKVKEVTINQKLVDEVGKDMKLVFTPLHGTGRMLGEKALKNAGFKNFSVVKEQAVADPEFSTVKFPNPEFPEAFKMAIDLGKKEGADVLIAVDPDADRLGTAVRQPNGEYVLLTGNQIAAVLLHYILQANKDAGTLPTNAAAVKSIVSSEFATKVAASYGVTMINVLTGFKYIAEQIEHFEATGEHTYMFGFEESYGYLIKPFVHDKDAIQTTVLLAEVAAYYKQQGKNLYDGLQDLFKEYGYFREQTTSEEFDGVGGSDKIAALMTKFRSEAPTAFAGYDVTGTEDFQSQTESFADGHTAPIALPKANVLKYHLNDGTWIAIRPSGTEPKIKFYIGTLGSTLEEANDKLAKFEDAIQAFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM29</accession>
    <name>F9UM29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888782.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0810"/>
    <dbReference type="EnsemblBacteria" id="CCC78268">
        <property type="protein sequence ID" value="CCC78268"/>
        <property type="gene ID" value="lp_0810"/>
    </dbReference>
    <dbReference type="GeneID" id="57024509"/>
    <dbReference type="KEGG" id="lpl:lp_0810"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.685"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_1_9"/>
    <dbReference type="OMA" id="FGMGVKD"/>
    <dbReference type="PhylomeDB" id="F9UM29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-704-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="18631" checksum="905E428616D96462" modified="2011-10-19" version="1">MAEEVVDVRPAEVADAAQLLALLAQLGRESNTFTVDEGIEDLSETDEQAQIERINGTTTNIIFVATLDSRLIGVSTVQASTDFSAAQGEVGVAVLKEFWGMGLGTALIEEVLDWARNYSSLERLVLTVQLRNVRAVKLYQHLGFENCTATSYDVVDPTGKRVPAIDMGIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM36</accession>
    <name>F9UM36_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1361 family</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <property type="entry name" value="DUF1361"/>
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            <end position="24"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="protein sequence ID" value="CCC78311"/>
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        <property type="entry name" value="AA/rel_permease1"/>
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        <property type="entry name" value="AA_permease_2"/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC78344.1"/>
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    </evidence>
    <sequence length="618" mass="68490" checksum="CF115E81433B38DB" modified="2011-10-19" version="1">MDQVSLVIILLAALLIPLIMAKFKINSLPTAVMEIIVGIVIGPSVFNFVNTSDLISQLSTIGVIVLLFLSGLEIDFSLFKKRRTALTPLEQKNAVNTPKYSPVRLSVYAYSTIIVLSLLLAAAFKVSGLFSDFWLAAILFGTISLGIVIAALKEQELLSKAFGQTILLISVFGELVPMMGLTLYASVYGSNSQSLWLLLLILAVAALLLLRFKPFFRFYQNINKSTTQLDIRLAFFLIVTMVTVAESVGAENILGAFVAGIVLKLLNPSETTRERLDAIGYGFFIPIFFITTGVDLNLRTLLTSGKTLLLIPLFFLAYMVAKIGGYWVLKLRFKQANALAGTALTATTMTMVLAVLRVAKSMKTITSDQSGAFLLAALLTCVISPLIFNKFYSAEKEDLVKTAVHFIGANLSTVPVAQQLRKGWYDVSMYTNHPENYQTYHAQVPVTLMENFTAQDLQDHGVFDTDILVLGHIDAERNYELAKAAKTYGVRRIIVRFEDRNVLNEHEDELRELGVEVYNTPEANITLLRALIESPSTLLLLNDTENSIYEVRVLNHLYTDVQIKNLQFAQDITISQVIRNRKLIAPNGNTTIMYGDRLIFTGNKQTAAQIRQALATAN</sequence>
</entry>
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        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CCC78355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="12238" checksum="2452CB9677B64A4C" modified="2011-10-19" version="1">MKSKNLALTNGIVGLVGGIILLFGGWFIAGGIVSDAATGSVSNTSGAAAFLNILKIAILALGIIALIYYKGDKRVGTASGVLLIVGGAIALIPFLGWIGGILAIIGGSLYLASLKHFSQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC4</accession>
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        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
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    <gene>
        <name evidence="3" type="ordered locus">lp_0925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="HFYLLWG"/>
    <dbReference type="PhylomeDB" id="F9UMC4"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="258"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="270"/>
            <end position="291"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="325"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="16"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="615" mass="68643" checksum="DD2C55D263CB7FF1" modified="2011-10-19" version="1">MRIKWFSLVRITGLVLVLTYHFFQTQFTGGFIGVDIFFTFSGFLITSLMVDEFARSDNFKLMAFYGRRFYRIVPPLFIAVLLVLPLTYLIDHDFVTDIGKQVAAALGFTTNYFEIATGGSYENKFIPHLFVHTWSLAVEMHFYILWGLIAWLVAKISRRLASGRRALTRFRWGLGLLTTAFAIESFVMMYFGAVGLKDFSPVYFSSLTHCFPFFVGGLIGVLSGIKAQGPIYRWTTAHCNPIIAGAVMLISFILLVALGDRMKFDALQTYQGGLLLATVLAGIMIYGARLLHDHTPNLKEPRWMTFLADVSYSVYLYHWPLYVIFSHMMVNWLAALLTTVLSIILSALSYYVLEPVIAGKRAHVFGHTVTWRQLQLPVITAGVLLAVNTGVVVKNAPQLSTLEQNLWVSGIYQDIDKIGTTHEAVLAAVTPKKKQATPKGDQEKAPGVSIIGDSVTLGTRSYLGDHVANSNIDAEGDRTMNLAYKVMMNQQRSHTLRQYVVICIGTNALDDYEEQTMKIIHDLEPGHKLILMTPYNARADADWNSSKLAVLERRLPAKYKFITVADWGKIAAQHPEVFKGTDGVHFGGIRAGDILYAKVINQALTAAKQTPAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD8</accession>
    <name>F9UMD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888891.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0941"/>
    <dbReference type="DNASU" id="1063980"/>
    <dbReference type="EnsemblBacteria" id="CCC78377">
        <property type="protein sequence ID" value="CCC78377"/>
        <property type="gene ID" value="lp_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="57024618"/>
    <dbReference type="KEGG" id="lpl:lp_0941"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.799"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_6_9"/>
    <dbReference type="OMA" id="MDFHHHL"/>
    <dbReference type="PhylomeDB" id="F9UMD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-813-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="35658" checksum="42BB973BA7499F2A" modified="2011-10-19" version="1">MAQHVKFHQYFFQWMQLYKLDAVRPVTYRKYEMSHRQLVTLAPDLKMADLSRLTYQQLLNDYAETHERQTTMDFHRHLKGSLIDALEEGFIDRDPTRKAIIKGIKHRQHKTKYLHQYELQALLNELNLNNEVNWDYFILLIAKTGIRFAEALGVTPDDFDFAHQTLSISKTWDYKSNKSDFAPTKNNSSVRKVPLDWQTVIQFSQLTKKLPEDQPIFVQAKVYNDTVNHYLERLCKHASIPVISVHGLRHTHASLLLYAGVSIASVARRLGHSNMTTTQQTYLHIIQELENQDNDKVMKHLASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI2</accession>
    <name>F9UMI2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cold shock protein CspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cspC</name>
        <name evidence="5" type="ordered locus">lp_0997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0997"/>
    <dbReference type="EnsemblBacteria" id="CCC78421">
        <property type="protein sequence ID" value="CCC78421"/>
        <property type="gene ID" value="lp_0997"/>
    </dbReference>
    <dbReference type="GeneID" id="57024661"/>
    <dbReference type="GeneID" id="66448915"/>
    <dbReference type="KEGG" id="lpl:lp_0997"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.844"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_9"/>
    <dbReference type="OMA" id="GPCANKV"/>
    <dbReference type="PhylomeDB" id="F9UMI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-857-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7308" checksum="558D2F37D40082FA" modified="2011-10-19" version="1">MEHGTVKWFNADKGFGFITRENGSDVFVHFSAIQEDGFKSLDEGQAVNFDVEESDRGPQAVNVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW5</accession>
    <name>F9UMW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface hydrolase, DUF915 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
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            <title>The crystal structure of the putative cell surface hydrolase from Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Zhang R."/>
                <person name="Li H."/>
                <person name="Cobb G."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 40-288</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78554.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=40-288"/>
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    <dbReference type="GO" id="GO:0004177">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3LP5"/>
        </source>
    </evidence>
    <sequence length="288" mass="32689" checksum="2B0829FD77DCBC06" modified="2011-10-19" version="1">MLKRYWWRWLLGIGLLVGICWPAYTWSQANIKTLKNTGRTRMAPVIMVPGSSASQNRFDSLITELGKETPKKHSVLKLTVQTDGTIKYSGSIAANDNEPFIVIGFANNRDGKANIDKQAVWLNTAFKALVKTYHFNHFYALGHSNGGLIWTLFLERYLKESPKVHIDRLMTIASPYNMESTSTTAKTSMFKELYRYRTGLPESLTVYSIAGTENYTSDGTVPYNSVNYGKYIFQDQVKHFTEITVTGANTAHSDLPQNKQIVSLIRQYLLAETMPDKVRQKNAQRVQN</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1204"/>
    <dbReference type="EnsemblBacteria" id="CCC78591">
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        <property type="gene ID" value="lp_1204"/>
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    <dbReference type="KEGG" id="lpl:lp_1204"/>
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    </dbReference>
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        <location>
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            <end position="353"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="379" mass="44104" checksum="798F6000BB8D4FE0" modified="2011-10-19" version="1">MARYSRIFMFSLKYTIFCIVIVGLLLLIGSICKSRRSGTFTFFTLLAVISAIRVNTGSDYFNYYINYETVTNYYNRLIDTITSRYQFGIISMDYAVQKLFGNSNGLFIAISVVVSVILWGIFRCYSQFPRISASVWLLSGFYLISNNLLKQYIAMLFMMIGYFFMRRRHFVLFIFCTFLASVFHLTALLVAPMYFFSTHIPVTKRSLVLCCTFGGALLVIVYPIIRILVKVRLFSKYEQYLDSAATVGYRFIIASVIMGVFYFVIVSVYLRSIESLSEDARQYIRMIMIGLILTIVSVRFFYLSRVAYYFLQFLPLLVANAFNKQMNDTTIARTMRSWILIWLTIYCFLFTAFSGENNYYNYSTIINDVPVSVQEFISR</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78595">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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            <fullName evidence="3">Transposase</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1212"/>
    <dbReference type="EnsemblBacteria" id="CCC78598">
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        <property type="gene ID" value="lp_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1212"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_027402_4_3_9"/>
    <dbReference type="PhylomeDB" id="F9UN09"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
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    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
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</entry>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889139.1">
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    <dbReference type="EnsemblBacteria" id="CCC78625">
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        <property type="gene ID" value="lp_1243"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="entry name" value="HTH_XRE"/>
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    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCC78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="13808" checksum="3C905CC2A4CE9054" modified="2011-10-19" version="1">MAFLKIDNGELLKNIRQFAKKNGLTLAEVATLAGLSASAIYSWKKHTPSVGTLKEVAQVLGTSYTKLVGKDKEPTAKATNAAAVDLKKVIENKKNQFEYDGQPITNEQMKIIRNVLKSMFKTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN52</accession>
    <name>F9UN52_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppB</name>
        <name evidence="7" type="ordered locus">lp_1262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="CCC78641"/>
        <property type="gene ID" value="lp_1262"/>
    </dbReference>
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    <dbReference type="GeneID" id="66449138"/>
    <dbReference type="KEGG" id="lpl:lp_1262"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_9"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="PhylomeDB" id="F9UN52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1082-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="33683" checksum="162FF7C50FE2FC21" modified="2011-10-19" version="1">MRKYLLKRIFYLFLTLFIVATATFFLMKLMPGTPLQNEAKLTPSEKASILAQYGLDKPVWLQYFIYIGGIFKGSLGLSFQFSDQAVSYLIGSRMGPSMQLGGQAMVVGIVFGIILGAVGAIKKDTWADRLATILSILGIAVPSFVLAILLQYYLGLKAGWFPVAGWEGFAYTILPTLALAASPLAETARFIRTDMVDVLSSDYIELAKAKGLSKFGIVYHHALRNSLIPMVTLIGPLAAALMTGSMVVENIFSVPGIGEQFVKSILVNDYPTIMGVTIFYSALLCLLLLLTDIVYGIIDPRIRLNGNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN78</accession>
    <name>F9UN78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE1</name>
        <name evidence="2" type="ordered locus">lp_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889181.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1299"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78667">
        <property type="protein sequence ID" value="CCC78667"/>
        <property type="gene ID" value="lp_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1299"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1099"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_21_0_9"/>
    <dbReference type="OMA" id="HRIISVA"/>
    <dbReference type="PhylomeDB" id="F9UN78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1125-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="498" mass="57747" checksum="1954535FC3DA064F" modified="2011-10-19" version="1">MYYFVGTGLGLKLTGIEKAQLNRLALFDAAGYQARCVYVTYNPRLHEHAARFGAEGKCFSLYDFFQGTMPEAVTKIHHDWMHYWQAVCHFKVIQVPNTTDFRVLDTDGQYLMYVHFVDAGRQQLDYVNYFDNQSVKVRREFYDNRGFLSRTSFLVKHQEVHTEVYYDLQGQVKIIKQYDITGPEPKLRLITLKNYQQRDFFFNTEQAFQTFFFNELGTADDVYFCDRNRQTAAALGHTRPAIRVCSVLHSTHLRIGEDVVSGHLKSVYRYVLAHPDQFHRIIVSTEHQKRDLLARYDNLPPVVVIPVGYTTVHPVKIDGRDPHRIISVARYSPEKQLPHQLEVVRRLVGEFPDLTLQLFGHGQKIEMQMRQFIQANHLEKNIVIRGFLPNLAEEYQRASLALMTSVEEGFSLATMEAESYGVPVIGYRIAYGPEDIIEDGVNGYLVTPNDVDELTMKVRQYLQHPERQAQLITNAYNSATRYSKQTIIEKWRQLIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN85</accession>
    <name>F9UN85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE3</name>
        <name evidence="2" type="ordered locus">lp_1312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101349.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889188.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1312"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78674">
        <property type="protein sequence ID" value="CCC78674"/>
        <property type="gene ID" value="lp_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1312"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1106"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_21_0_9"/>
    <dbReference type="OMA" id="CDRTVEC"/>
    <dbReference type="PhylomeDB" id="F9UN85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1132-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="323"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="508" mass="57863" checksum="73E9B8A5B8070BC4" modified="2011-10-19" version="1">MYYFLNDNMQFSKSGIEQAEINRLTLFKKHHVAAKIVTRVFAMNLHDVLEGANIADADFVNLFDFFCGSQSVKRQRFDLADFEVPADAIKTRKDNQIQVMERGKLIMIIYLRAGTEAVSNVQYFDVNGRTLKMSWWDTRGFKCLEQLFDWDGKIAQEAYFGPDGLIHVEKLHLLNHAGQERITWRVLNYNEQSHTFNGMNELTRYFYDELNQLNDEQNVFICDRTVECAWGLFNMTTSAKKVLHLHNNHVSDAKDIMHSTLNNNYANALNNWAAWDAVISATPEQTKDVEARFGKDIPAFTIPVGYVDNATLKAAPVKFDQRQKDLVVQVARLAPEKQQNHSIEAFVEVHKHFPDAKLELWGYANGDIEKQLHAQVAAAHLEDVVLFKGYTTDVNAVYNRAQLGLLPSRAEGFSLMLLEAQAHGLPMVANDVKYGPSDIIQDHKSGILTTDGDVQQLTKTILELLKNQGQLAQYSAQAYENAKRYSEEAVFKQWQALLDYFKPAKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN94</accession>
    <name>F9UN94_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644234.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1322"/>
    <dbReference type="EnsemblBacteria" id="CCC78683">
        <property type="protein sequence ID" value="CCC78683"/>
        <property type="gene ID" value="lp_1322"/>
    </dbReference>
    <dbReference type="GeneID" id="57024939"/>
    <dbReference type="KEGG" id="lpl:lp_1322"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1115"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="ANDWEAD"/>
    <dbReference type="PhylomeDB" id="F9UN94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1141-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="17795" checksum="89DA505ACE9FD6AA" modified="2011-10-19" version="1">MTMVKRILVGIDTSPQSQLALTKAIKIAVEQNAALDIVTVINTEKFIGVTQGPMGFGATTPQALNELTAGLKANLAKARQQAMAAGVSDVRVHLHSGNSKLLLATTLPDRYGTDLIVVGATGLNNVARVLIGSNAAYVIRNATCDTLVVRTDADQQPVKLPKHTTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG4</accession>
    <name>F9UNG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transpeptidase-transglycosylase (Penicillin binding protein 2A)</fullName>
            <ecNumber evidence="11">2.4.1.129</ecNumber>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pbp2A</name>
        <name evidence="11" type="ordered locus">lp_1413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="11"/>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1413"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78753">
        <property type="protein sequence ID" value="CCC78753"/>
        <property type="gene ID" value="lp_1413"/>
    </dbReference>
    <dbReference type="GeneID" id="57025044"/>
    <dbReference type="KEGG" id="lpl:lp_1413"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1185"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_2_9"/>
    <dbReference type="OMA" id="VHGMGLA"/>
    <dbReference type="PhylomeDB" id="F9UNG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1214-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="91"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="709" mass="77773" checksum="BFFCC506769ABED4" modified="2011-10-19" version="1">MQKNGFWATIKDGLRVIGNWLAPYWQRFAAVVGYQWHRRQITRWLIVLVLTVILIGSAYLTYEAKTAKVGNLQAELEKTTEIYDKDNKKAGSLYSQKGTYVHLSSISKNLQNAVISTEDRNFYKEHGFSVKGIGRAFVLLVINKILGRDYISGGGSTLTQQLVKNAYLTQQQTFSRKFREIFLAIETENVYSKGQILAMYLNNAYFGHGVWGAEDASERYFGVHASELSVDQAATLAGMLSSPSGYDPINHPKASTARRNVVLNNMVANNKLSKSEYKLYSQKAMTLTNNYHYESGYNYPYYFDAVIDEAINKYGLTESDIMNRGYKIYTSLDQDDQTQMQDSFKDSTLFPANADDGTKVQGASIAVDPSTGGVLAVVGGRGKHVFRGFNRATQIKRQPGSTIKPLAVYTPALQNGYTYDSNLSNKKQTFGANKYAPKNYDNVYSKSVPMYTALSQSMNIPAVWLLNKIGVNKGYQSVKKFGLPVTKSDDNLALALGGLTTGVSPAQMTSAYTAFANGGKKTTAHFITKIVDASGNVVVDNTKTKTKKIMSASVAKEMTSMMLGTYNSGTGAAAKPYGYSVAGKTGSTQADYSTGSGTKDQWMIAYTPDIVVTTWIGFDTTNSTHYLKSLSENQLSSLFKNELQNILPNTNNTSFGTKDAATLATESNSSDSDSSDSGSSVWENVEKGANAVKNKAKDWFSKAKSFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI4</accession>
    <name>F9UNI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1440"/>
    <dbReference type="EnsemblBacteria" id="CCC78773">
        <property type="protein sequence ID" value="CCC78773"/>
        <property type="gene ID" value="lp_1440"/>
    </dbReference>
    <dbReference type="GeneID" id="57025074"/>
    <dbReference type="GeneID" id="66449275"/>
    <dbReference type="KEGG" id="lpl:lp_1440"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1206"/>
    <dbReference type="eggNOG" id="ENOG5031R2N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124401_0_0_9"/>
    <dbReference type="OMA" id="KNIEHWE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1234-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="20302" checksum="D98FA0177B839101" modified="2011-10-19" version="1">MTKKYVANIVPLNAEGIGTAPHGTATFTETGNQLHVTIEMFDTPANTQHWEHFHGFPDGKAAQIATMAQDVNHDGFVDLPETEPVSGTTMVPFDNAPHHMDVPNDNYPVADAQGHFAYEIDVPLGDLQAKFKEVFGTDDLELDKRVIYIHGVPQDLALPASVAGEVGMYDAHVTLPIAVGKIEVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ6</accession>
    <name>F9UNJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78785">
        <property type="protein sequence ID" value="CCC78785"/>
        <property type="gene ID" value="lp_1455"/>
    </dbReference>
    <dbReference type="GeneID" id="57025086"/>
    <dbReference type="KEGG" id="lpl:lp_1455"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1218"/>
    <dbReference type="eggNOG" id="COG1131">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="PhylomeDB" id="F9UNJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1246-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="26767" checksum="F040FEE8B7EC4FFC" modified="2011-10-19" version="1">MTLAVQHLVGGYSQIPVLKDISFQVEPGELVGLIGLNGAGKSTTINHIIGLLTPMKGSIALNGVTLAQDPQSYKSQIAYIPETPILYEELTLKEHLEMTMLAYGLDQEQAWQRAHDLLKTFRLANKLDWFPANFSKGMKQKVMIVCAFITNAKLFIIDEPFLGLDPLAVHDLLALIATVKAQGAAVLMSTHVLDTAEKACDKFVLLHAGEVQTQGTFAEIKANYPDAGESLNDIYLSLTGVTRDE</sequence>
</entry>
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    <accession>F9UNK7</accession>
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        <submittedName>
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        </submittedName>
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    <gene>
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        <name evidence="3" type="ordered locus">lp_1467</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889310.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1467"/>
    <dbReference type="EnsemblBacteria" id="CCC78796">
        <property type="protein sequence ID" value="CCC78796"/>
        <property type="gene ID" value="lp_1467"/>
    </dbReference>
    <dbReference type="GeneID" id="57025096"/>
    <dbReference type="GeneID" id="66449356"/>
    <dbReference type="KEGG" id="lpl:lp_1467"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1229"/>
    <dbReference type="eggNOG" id="COG1918">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2700133_0_0_9"/>
    <dbReference type="OMA" id="LCEGCPI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1257-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8312" checksum="BD6F722939F5D1C4" modified="2011-10-19" version="1">MLSQSVTNTSQLHIQQFTGLDNQTVQRLHSLGLHVGSPLAVVRYYPFHGPVIVQIDQQRIGIRYTVFQTLIGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ6</accession>
    <name>F9UNQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78845">
        <property type="protein sequence ID" value="CCC78845"/>
        <property type="gene ID" value="lp_1519"/>
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    <dbReference type="PhylomeDB" id="F9UNQ6"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_assoc_2"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="420" mass="47747" checksum="828C6E3A9D2C1792" modified="2011-10-19" version="1">MAFKTPLADRMRPQSLEQMVGQQDLLKAGQPLRQIIDQHVNIPLILWGPPGTGKTSLAQIIASQDDYPFVAFNASTENKAQLTKAIAQYPEQSFVLLIDEIHRMTKTLQDFLLPYLENGHVMLIGSTTENPIMSIVPAIRSRCQIFEFQPLSDTDIEIALRRAVTDIYNLTDDQVDAKALNLIAISAEGDLRIALNILETLHAIDQKQITVAAVQHFAQQQHFSYDRKATKHYDYLSAYSDSMAGSDTDAALYYLTILLKNDDLPSVVRRLREIPYTYIGLANPEQVTQIVVAANQAEKIGMPKAKYPLMFATMLMCISPKSGSFDQSWEKLDQDTQNPSQHPMPRGLRDMHYKHSEEITGGGLIDNPFQMPHQIAQQNYMPKGLAGRRYYYPKDNENERKLGAQYLKLHRFIYNEDYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR0</accession>
    <name>F9UNR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ica1</name>
        <name evidence="3" type="ordered locus">lp_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101456.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889363.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1524"/>
    <dbReference type="EnsemblBacteria" id="CCC78849">
        <property type="protein sequence ID" value="CCC78849"/>
        <property type="gene ID" value="lp_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1524"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1283"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_0_2_9"/>
    <dbReference type="PhylomeDB" id="F9UNR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1310-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="437" mass="50388" checksum="477A0AA45D7A055F" modified="2011-10-19" version="1">MEIMQTLKPFESIWNFVLLLLVSYPILGAFAWFIGVLCYQLIYRHRHKDDIEFKQLTPAEQPFITIMIPAHNEEVMIEHTINYLMNNLNYEKYEVLVTDDGSTDETPAILERLQNVYDNLRVVTIKKNQGKAHAFNVGVGFARGEFILSNDADSIPEPDALWKYMSYFMGEEHANTAAVTANMDVQNRSTIIAKSQTVEFSSIVGVIKRSQVSALGNMYAYSGANTMYRRDALIDVGLFRQDRATEDISIAWDHQLNGWTTVFSPDILFYMNVPENLDALYHQRKRWAKGGTEVLLTNFKRVVSHPGKYLKQWAFITDQTLSIIWSLFFFVSTLIFLISLVTFFFTGNYERVYHMFCMAFIFVTFEMFAGVLQLLSALIVDDRGRKFKYLIFMPLYMLIYWQVNALALVTTLIPAVKTILGYGSGTWVSPVRKHHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU0</accession>
    <name>F9UNU0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ordered locus">lp_1561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640312.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889393.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UNU0"/>
    <dbReference type="STRING" id="220668.lp_1561"/>
    <dbReference type="EnsemblBacteria" id="CCC78879">
        <property type="protein sequence ID" value="CCC78879"/>
        <property type="gene ID" value="lp_1561"/>
    </dbReference>
    <dbReference type="GeneID" id="57025149"/>
    <dbReference type="KEGG" id="lpl:lp_1561"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1313"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_1_1_9"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="PhylomeDB" id="F9UNU0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1340-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="44757" checksum="4B33CCBE66A9774B" modified="2011-10-19" version="1">MEGRVLNNNQDNQDQKDQNDSQDRGVNEPNRSEQKQRKSFSKHVIGGVVGILVVLLIIVGVLGYRYFDNATQPYDSSDNRVVQVDIPYGANGKKIADILQREKVIKSGFVFEYWTKAHNLSNFHAGYYQLKPSMSLAQIAKALNKGGSSEPVQSSSGKVLIVEGSQIKTIAKTVQKQTDFTSAEFLALMKDQTFIKSLAKKYPQLLNSAMSAKQVRYRLEGYLFPATYVVGKKTTLKQLVTQMVSKTNDELEPYYAQIKKSKMSVQEVMTLASLVEREGSTTKDRRLIAGVFLNRLDAKWRLDSDISVFYAINSNKSTLTNKDLQTDSPYNLRLNLGYGPGPFNSPSLTSIKAVLDPAQRSKGYMYFVADLKTGDVYYAKDAAGHAANIKKVSKHNEAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP37</accession>
    <name>F9UP37_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="4">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabD</name>
        <name evidence="7" type="ordered locus">lp_1673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1673"/>
    <dbReference type="EnsemblBacteria" id="CCC78976">
        <property type="protein sequence ID" value="CCC78976"/>
        <property type="gene ID" value="lp_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1673"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1412"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_1_1_9"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="PhylomeDB" id="F9UP37"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1439-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="6"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="33308" checksum="B88D0F5824F6A0CA" modified="2011-10-19" version="1">MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAITAMNMGLYRALTALLNECPTVLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGLQHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQIVIGGDAAGIQAARTYLKTHGVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETLVKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYCQDTEEVRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP92</accession>
    <name>F9UP92_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">3'-5' exonuclease DinG</fullName>
            <ecNumber evidence="5 6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6 8" type="primary">dinG</name>
        <name evidence="8" type="ordered locus">lp_1737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">3'-5' exonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101529.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1737"/>
    <dbReference type="EnsemblBacteria" id="CCC79031">
        <property type="protein sequence ID" value="CCC79031"/>
        <property type="gene ID" value="lp_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1737"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1465"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_1_0_9"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="PhylomeDB" id="F9UP92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1494-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02206">
        <property type="entry name" value="DinG_exonucl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006310">
        <property type="entry name" value="DinG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01407">
        <property type="entry name" value="dinG_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="247"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box" evidence="5">
        <location>
            <begin position="463"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="286"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="934" mass="104976" checksum="65429E6FAD5737CA" modified="2011-10-19" version="1">MKPNTTYAVVDIETTGTSVKDGDRIIQIGCAFVKNNKIINTFATDVNPLTTVPAVIENLTGISNARVRKAPPFDDLAGTVYSLLQGTVFVAHNVNFDLPFINSELQRVGYPELPIQAVDTVSLSQILLPTASSFRLRDLSHLLAIDHNHPHSADSDAIATAHLFITLQQRLAHLPLITLQQMVQLAPELPRETADLFAYAFQQGKQHPQRLPTDLVIKNGLALRKQRLPQQAAGRKAARYPLTKAQKQHIFGDRLTYRPQQARMMNQIYRHYSKQSAEQVPLLIEAPTGTGKTLGYLLPLAYLAQDGQQVVVSTATTVLQTQLRDQGVALLNQLLPNPVTAVVIKGNQHYVDLNRFARGLALHEHSKQTQLLKLRVLVWLTMTTTGDLDELHLSTYQAPYFSEIAHHGVASLKADDPFFKEDFLRFRDQLTAQATFIITNHAYLMRHVAQLGSRQERPLLVLDEAQHLADGVVRDSRQTFDFNGYMATCHSLISRIDTEHSLNLRALFAEQPQADYRLKLLDNSLNDTDLHLQQLQAALARTFVPAQKGGNQPAELGITTDQLTDFFAAHNPLIKQLQTAIENCFLQFQQLNEQYQHDQSQILPSEQHVLDDFDNRLQHLRQGYELLQTWLVPASREQRVFWVSLNQWHDRGSLTLAGSLIDTQGYFKTQLYPYFSAPLLTGATLFATGKSQYVYSQLDIDQATAKHHRLSPPFDLEHQARLFVATDATAAEAPSGKQRVAYLTHAIHDIVMAAPKQTLVLFNSLNMIEAVFYSLHQTDLPGDREILAQGVNGSREKLLRRFMQGDDAILLGAGSFWEGIDLPQEQLELLIVTQLPFESPDQTTTKARYQQLRQAQLNPFYNEALPKAALKLRQGIGRLIRTDEDRGAAVILDDRLMTKRYGQTILKALPKTLPPATGSLTMITQELQSFFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE3</accession>
    <name>F9UPE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1796"/>
    <dbReference type="EnsemblBacteria" id="CCC79082">
        <property type="protein sequence ID" value="CCC79082"/>
        <property type="gene ID" value="lp_1796"/>
    </dbReference>
    <dbReference type="GeneID" id="57025409"/>
    <dbReference type="GeneID" id="66449643"/>
    <dbReference type="KEGG" id="lpl:lp_1796"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1517"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_1_9"/>
    <dbReference type="OMA" id="MALGFCA"/>
    <dbReference type="PhylomeDB" id="F9UPE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1545-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="32203" checksum="90AB4E433C191385" modified="2011-10-19" version="1">MKIAVVTDSTSYLTPQEVADNDIHVVPIPVIIDGKVYQEGVDIKTADFYANMKSFKSFPSTSQPPVGEMVAFYNRLGEQGYDAVISIHLASTISGFYNSLMNMRDMVDNIKLYPYDSQITVRLMGYLAIEAARMAKAGHSVEEILARLDDLRASMGEYFIVDDLQNLVRGGRLSNASAFIGSVLRIKPLLTFDDQSHEIVAFEKVRSTKKALARVEHLFAEAQSKVDYPLRAIIVQGNNLAAAEDWKQKLQQIYPDMPIDITYFGPVIGAHLGDKSLALAWLKDIDKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPF1</accession>
    <name>F9UPF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889604.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1806"/>
    <dbReference type="EnsemblBacteria" id="CCC79090">
        <property type="protein sequence ID" value="CCC79090"/>
        <property type="gene ID" value="lp_1806"/>
    </dbReference>
    <dbReference type="GeneID" id="57025417"/>
    <dbReference type="KEGG" id="lpl:lp_1806"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1525"/>
    <dbReference type="eggNOG" id="ENOG503370N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155280_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UPF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1553-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009303">
        <property type="entry name" value="DUF960"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06124">
        <property type="entry name" value="DUF960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="102" mass="11530" checksum="3E0D0960F953D9A4" modified="2011-10-19" version="1">MFDQDEERFATLGLAAKLPSAVIDGIWDIIDQNLKGVVRLPRVLQFALIARNGQVTVAFDAQHDAIMEFDLPVNYQREFPETVAVLDDGQYQTMMLMDELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG0</accession>
    <name>F9UPG0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose-5-phosphate reductase</fullName>
            <shortName evidence="1">Ribulose-5-P reductase</shortName>
            <ecNumber evidence="1">1.1.1.405</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribitol-5-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">tarJ</name>
        <name evidence="3" type="ordered locus">lp_1817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57695"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.405"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.405" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UPG0"/>
    <dbReference type="STRING" id="220668.lp_1817"/>
    <dbReference type="EnsemblBacteria" id="CCC79099">
        <property type="protein sequence ID" value="CCC79099"/>
        <property type="gene ID" value="lp_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1817"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1535"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823603_0_0_9"/>
    <dbReference type="OMA" id="HADQRYF"/>
    <dbReference type="PhylomeDB" id="F9UPG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1562-MON"/>
    <dbReference type="UniPathway" id="UPA00790"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050256">
        <property type="term" value="F:ribitol-5-phosphate 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902012">
        <property type="term" value="P:poly(ribitol phosphate) teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02069">
        <property type="entry name" value="TarJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034710">
        <property type="entry name" value="TarJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="38206" checksum="7E4C964BA7AB555F" modified="2011-10-19" version="1">MLNQVYRLVSPRQFEVETVAEEVDADDLIVRPKFLSICHADTRYFFGQRSQAALRAKLPMALIHEAVGEVVYDPRNEYKPGTLVAMVPNTPVKKDSIIQENYLPSSRFRSSGYDGFMQEYVCLRRDRAITVPSDFDPHMAAFIEMVSVGVQALTKLESTMDEDQRVIGIWGDGNLGYITATLVKQIFPDSQLLVFGRHQSKLDYFSFADKTYLVDDIPADVKVSQALECTGGQGSEAAIQQIIQHIQPMGTAILMGVSENPVGIDTRSVLAEGLTLRGVSRSSREDFKRAVDILSSSPVTRERLQNLVGYVQKVSSIQDITNFFDSALTNYWGKEVMEWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR3</accession>
    <name>F9UPR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system histidine protein kinase sensor protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpk6</name>
        <name evidence="3" type="ordered locus">lp_1943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1943"/>
    <dbReference type="EnsemblBacteria" id="CCC79202">
        <property type="protein sequence ID" value="CCC79202"/>
        <property type="gene ID" value="lp_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1943"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1640"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_9"/>
    <dbReference type="OMA" id="WLAYLPY"/>
    <dbReference type="PhylomeDB" id="F9UPR3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1665-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="367" mass="41874" checksum="07F994A5477B8A5D" modified="2011-10-19" version="1">MLTHHKNKLKTIEWTSYVWLAYLPYTIAAYIPVKSWHDWLWLLLVGGFLVLYILVVEKPHWRAVTMPAELVVTGLFAVFAANNFMIIFPGWQVSFLLGRRPKREFYGFALGYYAFLIGGCIRDYLQYPGVFGWHNGDVMGLVFPLLSPILAYTFSWSVERQRQLNQTNRRLKTIVERNERERIARDLHDTLGQSFSMITLKTELAKKLLVKAPEKVAPELDEIEQTSRQNLQLVREIVNNLHEQSLTEVLLAQTRNLAAVGVWTTTTGETQATKWPTTVQSCFAAVLVEAMTNVMRHAHAHEVRIDFVETAKIYQIKLKDDGKGGTLIRQGANGIAGMRTRLQAKQGTFAITSSRRGTQLILTLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ20</accession>
    <name>F9UQ20_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101644.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889823.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79309">
        <property type="protein sequence ID" value="CCC79309"/>
        <property type="gene ID" value="lp_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2066"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1751"/>
    <dbReference type="eggNOG" id="ENOG502ZGUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115364_0_0_9"/>
    <dbReference type="OMA" id="VIYARQT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1769-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="23002" checksum="39906A60574FCD0C" modified="2011-10-19" version="1">MLFLAIMGLIVFLLALFSVIYARQTGGGWKFLTLITVLSALVTIYAVVKLPYWPYNQSQQSTRKASSSTSTSTSTSKSKSTSLSSSQVVFNEASTKRAAATTKLNEENILKQLQSNYQSIGTVAFTKSTKTYTITPTNKKYVKSLKTIKSYPSQNQKAITTITSNFKSLSKSLQKNLAAGYTIQLLQPDTTDKTLLSVQDGQIMTNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ33</accession>
    <name>F9UQ33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640766.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2084"/>
    <dbReference type="EnsemblBacteria" id="CCC79322">
        <property type="protein sequence ID" value="CCC79322"/>
        <property type="gene ID" value="lp_2084"/>
    </dbReference>
    <dbReference type="GeneID" id="66449856"/>
    <dbReference type="KEGG" id="lpl:lp_2084"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1763"/>
    <dbReference type="eggNOG" id="ENOG502ZBIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051151_2_1_9"/>
    <dbReference type="OMA" id="HIAVFIA"/>
    <dbReference type="PhylomeDB" id="F9UQ33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1783-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="403" mass="43099" checksum="A5E761400F99DB18" modified="2011-10-19" version="1">MKNLGRNRAFVTLTVADLFETIGTSLFNIILLTYARTFAQANLMVSLVSVATVLPGIFGMLTGRLADSQTNKRGWLAGLKFVQAALYLVLAQLITEKQVGLLLIIIVINLCSDVLGMLSGSLRMPLLQAKVASELQEEALGINQGIGVLMQTMGQALGVSLLAATGDYRLAGYLNAITFLIAGLVLLSGYETLKLPSATVTVTSTFRQLLRQVRQAMEAGVHMNVLALLGSVLFLNAVGASVDALLNLYLIHRATQLPFSFGVAILVMNTADVFGSVAGNLLHTGYFQRWTFRGVMLTTVVAFEGLFINLLFWQNYWVVVTIMMIGGFCMGQANPKLMASLLKVADQSIVGSLGGIINSLATISIPIGSVGLVLLDNIVSPEAAYLTAMGLLLACGGCLFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ40</accession>
    <name>F9UQ40_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644565.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889843.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79329">
        <property type="protein sequence ID" value="CCC79329"/>
        <property type="gene ID" value="lp_2093"/>
    </dbReference>
    <dbReference type="GeneID" id="57025636"/>
    <dbReference type="KEGG" id="lpl:lp_2093"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1770"/>
    <dbReference type="eggNOG" id="ENOG5030U54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165429_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1790-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="94" mass="10909" checksum="E6E0D1C15BFD778E" modified="2011-10-19" version="1">MRLIDFNLSTADLQQTLPLYWELTTNQIWPIQSVTLVDHQLVLVASKSALPLTLDQFNARTRQIDGQTQLCIQTPPRPRRLFGYRLSQQRLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ43</accession>
    <name>F9UQ43_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="5">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fruK</name>
        <name evidence="7" type="ordered locus">lp_2096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14213"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.56"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644568.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889846.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2096"/>
    <dbReference type="EnsemblBacteria" id="CCC79332">
        <property type="protein sequence ID" value="CCC79332"/>
        <property type="gene ID" value="lp_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2096"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1773"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_1_0_9"/>
    <dbReference type="OMA" id="GETRSNI"/>
    <dbReference type="PhylomeDB" id="F9UQ43"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1793-MON"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="32449" checksum="4B8EF84BD995456B" modified="2011-10-19" version="1">MIYTITVNPSIDYVVQLPQMTLGSVNRLAHTAKLPGGKGINVSQILNDLDQPNKALGFIGGFTGTFISDALKAKGLDCHFTPIADDTRINVKIHAEEETELNGAGPDITAKEIEAFYTELANLTPNDVVVMSGSLAPSLPDSFYYDIIQKVEAAGANFVIDTTGEALKKTLPSHPLVVKPNNHELADYYHTTFNSQADIIAAGQRMLAEGAQHVLISMAGDGGLLITKDAVYFSPAPKGQVINSVGAGDSMIGGFVGTFAKTHDAVESFRYGLACGSATAFSEDIATRAKIDEILPLINIEKLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ48</accession>
    <name>F9UQ48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps4H</name>
        <name evidence="2" type="ordered locus">lp_2101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2101"/>
    <dbReference type="EnsemblBacteria" id="CCC79337">
        <property type="protein sequence ID" value="CCC79337"/>
        <property type="gene ID" value="lp_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2101"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1778"/>
    <dbReference type="eggNOG" id="ENOG50317XH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646883_0_0_9"/>
    <dbReference type="OMA" id="FINDLFM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1798-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="424" mass="47231" checksum="4FB893FA291525A8" modified="2011-10-19" version="1">MTAVNRQIGGPFLRLGLLIAGFYLIYQPNFWSSSYVPLIVTLGITGGCVLLLSPKDLSIAINRLHIFVIGVMLSVIYFAFRAKLAGTDPRVFQNVVIILNVLALVLWLEVLRKYFNVTSETVLTWMLWMVVVQCLFALVMLASSGIRAAILAKTATGIIQNQFIYGERLYGISSDYTFFTPIYHSLMGLVAIYMGMNLGKKYYWFLPFCVFIIVLNGRTGLITLAFGFALMLVKRMLSSVRGLFQVALIIVLSVTFIILGLAFLQSIQPDTYTWIVSGFEDTFALVFEGSKQGNYEQLTGSFLMFPSQLLDWVFGYGVRVYGGNANNIWFGTSDIGFINDLFMGGIIYMALLYGTIIASLTACHKKSGKVVRDSKIFLAFGVVLLIANYKGEVARSGMVLTAIIFLGYLLSTELKIEEKKWQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ86</accession>
    <name>F9UQ86_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="4">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">typA</name>
        <name evidence="4" type="synonym">bipA</name>
        <name evidence="6" type="ordered locus">lp_2146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889889.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2146"/>
    <dbReference type="EnsemblBacteria" id="CCC79375">
        <property type="protein sequence ID" value="CCC79375"/>
        <property type="gene ID" value="lp_2146"/>
    </dbReference>
    <dbReference type="GeneID" id="57025681"/>
    <dbReference type="KEGG" id="lpl:lp_2146"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1816"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_9"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="PhylomeDB" id="F9UQ86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1836-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="612" mass="68468" checksum="FDCDB2900A4E2CB4" modified="2011-10-19" version="1">MKFRDDIRNIAIIAHVDHGKTTLVNEMLKQSDTLDEHVQIDDRAMDTNAIEKERGITILSKNTAVRYGDKQINILDTPGHADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALEQHLTPIVVINKIDRPGARPEEVVDEVLDLFIELGADESQLDFPVVYVSALNGTSSYESDPAKQEHTMQPIFDTIIKTIPSPIDNSDEPLQFQVALLDYNDYVGRVGIGRVFRGTIKVGDSVSVMKLDGSKKNFRVTKLFGFFGLQRLEINEAHAGDLVAVSGMEDINVGETVADSANPEALPILRIDEPTLQMTFGTNSSPFAGKEGKFVTARQLEMRLKAELETDVSLRVDDTDEPGSWVVSGRGELHLSILIETLRREGYELQASRPEVIYREIDGKRCEPFESVQIDTPDEYTGSIIDTLSKRKAEMKNMESTGNNQTRLTFLAPSRGLIGYSTEFLSLTRGYGIMNHTFSEYLPVIPNWNPGRRNGALVSINQGKTTTYATMGIEDRGTIFVDPGTEVYEGMIVGQNSRENDISVNITKGKNMTNVRSSNKDLTATIKTPTHLTLEESLEFLNSDEFCEITPDHVRLRKRILNTNSREKEAKKRKMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA8</accession>
    <name>F9UQA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101676.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889911.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2175"/>
    <dbReference type="EnsemblBacteria" id="CCC79397">
        <property type="protein sequence ID" value="CCC79397"/>
        <property type="gene ID" value="lp_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2175"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1838"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_5_0_9"/>
    <dbReference type="OMA" id="GHFLEGY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1858-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389053" evidence="1">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="64"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="243" mass="24045" checksum="387D745C530C8765" modified="2011-10-19" version="1">MRTFKLMTGLSGGATLLSLALMPLAALAAGPGTASNNLTTVSSGYVADSTGNAEALSNAQFTVMPGELTLDAVPNIALSSTNVKNIVSAATTLNATSSNTSGGSGYDGNGSGNLNVSDFRGNHAGWTLTVGMGPFSSGAAKVDSATLNLNMTKGNADNANTAAPTALSLNQSEVTNGWVASPQTLWNAAADSGEGSNTATTATSSSLQVGKQSNISAGTYTATLYWTLQNAPAAAAATPKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI4</accession>
    <name>F9UQI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2265"/>
    <dbReference type="EnsemblBacteria" id="CCC79473">
        <property type="protein sequence ID" value="CCC79473"/>
        <property type="gene ID" value="lp_2265"/>
    </dbReference>
    <dbReference type="GeneID" id="57025810"/>
    <dbReference type="KEGG" id="lpl:lp_2265"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1916"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117108_1_1_9"/>
    <dbReference type="OMA" id="MITRREW"/>
    <dbReference type="PhylomeDB" id="F9UQI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1958-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="18760" checksum="B24981259AE1A2D9" modified="2011-10-19" version="1">MLIQPVEDLLSRNADHYLIPADVVANVQTDNNLYHAFLVLTKVKYSKIPVLDHGGHFEGLVSLPLITEQMLGFDQLNTEILLQKRVCDVMETQVKTVHDVDDVEETLHLMIDNPFVPVVDEQQIFQGIVTRREFMKSFNFLTHEIGKQYDMIEKDFSTSEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQK5</accession>
    <name>F9UQK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101705.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890008.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2289"/>
    <dbReference type="EnsemblBacteria" id="CCC79494">
        <property type="protein sequence ID" value="CCC79494"/>
        <property type="gene ID" value="lp_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2289"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1937"/>
    <dbReference type="eggNOG" id="ENOG50309TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545689_0_0_9"/>
    <dbReference type="OMA" id="DSQDTMT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1978-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="19259" checksum="DA5F38049BD9342E" modified="2011-10-19" version="1">MQLKPFKAVLPTTTGQTKIQTAATNWDSQDTMMTTEASYYWYELTLNGVHQWRLIGSWPVDQTVTTMVPGMINTVLYPQQPVIEMLIDDWVGHFAPVVEVTDTAHVTHRLWQITESEVNTDITTAMAPVTPQKTWLTTVSTPLVMLVSTSEWQKLATAPVIPEQLIALATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM2</accession>
    <name>F9UQM2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">minD</name>
        <name evidence="11" type="ordered locus">lp_2315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890025.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2315"/>
    <dbReference type="EnsemblBacteria" id="CCC79511">
        <property type="protein sequence ID" value="CCC79511"/>
        <property type="gene ID" value="lp_2315"/>
    </dbReference>
    <dbReference type="GeneID" id="57025847"/>
    <dbReference type="GeneID" id="66450059"/>
    <dbReference type="KEGG" id="lpl:lp_2315"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1956"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_9"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="PhylomeDB" id="F9UQM2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1995-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="10">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="268" mass="29101" checksum="D3CE7F19A27609FC" modified="2011-10-19" version="1">MGKAIVITSGKGGVGKTTTTANLGTALALMGKKVCLVDLDIGLRNLDVILGLDNRILYDIVDVVAGRAQIRQALVKDKRFDDLLFLLPAAQNADKDALNPDQVRAIVDELKPDFDYVLLDCPAGIEQGFMNAIAGADAAIIVSTPEISAIRDADRVVGLLEQYPLAEAPKLVINRIRTRMMQDGETMDIDEITHHLSIDLLGIVFDDDAVIRTSNNGEPIVLDPKNPASQGYRNIARRIEGETVPLMNLDTPKPGVWSRIAGIFHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQN1</accession>
    <name>F9UQN1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="2 6">6.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gshA</name>
        <name evidence="8" type="ordered locus">lp_2324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glutamate--cysteine ligase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101713.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890034.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2324"/>
    <dbReference type="EnsemblBacteria" id="CCC79520">
        <property type="protein sequence ID" value="CCC79520"/>
        <property type="gene ID" value="lp_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2324"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1965"/>
    <dbReference type="eggNOG" id="COG2918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020728_2_0_9"/>
    <dbReference type="OMA" id="QYLELRM"/>
    <dbReference type="PhylomeDB" id="F9UQN1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2004-MON"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007370">
        <property type="entry name" value="Glu_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006334">
        <property type="entry name" value="Glut_cys_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38761">
        <property type="entry name" value="PTHR38761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04262">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_cys_ligase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="412" mass="45948" checksum="24E7A9CF77BFF99D" modified="2011-10-19" version="1">MEWQQLLMENTALINAQVVQIGLEREGQRVTVTGHLADTALSPTLISELSGLQRDFAETQLELVTQPQASAVAALHALTMLTQQVRQRLLPELIWPLSMPPTLPREDRDIPIAKLDAAAVAYRQGLAHRYGRRRQMLSGVHCNVSLAASLMMGLYQAQTDSRDFTTFQNHCYLHIAQNYLHYRWLLTYLYGCSPRCWPQSGLTPPAQPVRSLRNSSSGYTNRPGVAVSYASLNDYCQTLQAAVDNGKLSATKEFYGQVRLRHAGGHSQLCQDGIQYLELRNLDLNPWAGAGIDLSQLTCLTWFVLLMLWLPVPASTDNWIQAGQRANEQVAIETPMQVTRQLTEGEQLADALQTMATSLHQPHALQVAQHILTSLHDPANTLAARWEQQTNDSLERATQLALQLATTPHFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU3</accession>
    <name>F9UQU3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101735.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2403"/>
    <dbReference type="EnsemblBacteria" id="CCC79582">
        <property type="protein sequence ID" value="CCC79582"/>
        <property type="gene ID" value="lp_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2403"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2029"/>
    <dbReference type="eggNOG" id="ENOG5030BGN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195232_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2067-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="79" mass="8331" checksum="D6E95523267A5045" modified="2011-10-19" version="1">MSFDLGKFLTEGLIDSVNNGLIPSDLATVYAGNYLVKSLITQAQVIQVSDAIVAYKAAQAEAAKQADSSLATQTEDTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ7</accession>
    <name>F9UQZ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 20</fullName>
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        <name evidence="1" type="ordered locus">lp_2461</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890150.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2461"/>
    <dbReference type="EnsemblBacteria" id="CCC79636">
        <property type="protein sequence ID" value="CCC79636"/>
        <property type="gene ID" value="lp_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2461"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2074"/>
    <dbReference type="eggNOG" id="ENOG5030B46">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012352_0_0_9"/>
    <dbReference type="OMA" id="FILHDYI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2128-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14512" checksum="FEA01CE5CC4779FB" modified="2011-10-19" version="1">MILMRQDVKKICNLLKQYAKLKRELTAFNQVSSPSFDGVSSHSSRNGAESRLINHVDLSYQLKEVEDVLNAIDDPQYQFILHDYIIKKRFSRSEACGQLSVSVSKFNYMKNEALHAFAKFYSDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR18</accession>
    <name>F9UR18_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mucus-binding protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101804.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2486"/>
    <dbReference type="EnsemblBacteria" id="CCC79657">
        <property type="protein sequence ID" value="CCC79657"/>
        <property type="gene ID" value="lp_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2486"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2093"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012702_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2149-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389059" evidence="5">
        <location>
            <begin position="49"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="371"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="453"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="530"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="601"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="675"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="924" mass="92571" checksum="5589010069E5E912" modified="2011-10-19" version="1">MSKDNQKMTGDSVYRVKMYKDGKRWVYAGATTLALAAGLVFANVNASADTAASSDATTEQVSSAASSAATSSTATSSAATDASSASSTATSTSSTASSTATTSSSAASSTASSAVTSTTSAASSSAETVSATTPASSDATSTSTATVAATAAKASVVTPASAAATATTTATTTAATTAPTVTAPASEAANQTAAGSVDAGTLTSATQSGGSGNLQDQAQYIQENVDGTNIKVTAGHTYAVAIRLTKSQALDWANASGQVSIAPNGSNSNGTWTAVEYATESGKEYSYAAGASTATVDITKLTDADSYVTVLYTFKANDDATTGSRAAYLEFTGTTSVNKLSTNTNNTDANQQIEAWSYATQVMDTSVAAGTVVVHYVDENGNKIADDTTVQGDVDNTYTVTPATFSNYTLDTTKSSALTGTVAADTTDSDGNVTAAGTELTLVYSQNTEASNLTVNYVDADGNTILPSKTYTEGADGTAAEVGGAYSVNAASIDGYTLTGDATQTGTFVSGGNTVTFTYTKDAAPVEQSTVTVNYVDADGNTIKAATTQTLDNGSTYTVETPTIDGYTYKSADAALTGTVDGNKTITLTYTKNATPVEQSTVTVNYVDADGNTIKAATTQTLDNGSTYTVETPTIDGYTYKSADAALTGTVDGNKTITLTYTKDSTTPVENKANLTINYVDADGNTIKASSVTEYIVGQAYTVGQPEIAGYSYNHSTGDAIAGTIGYNGNTVTLVYTKNGGTTTAPTTAPTVAPTTAPTVAPTTAPTTAPTVAPTTAPTTAPTTAPTVAPTTAPGTGDNVNGGGTGTTTTAPVTTPSDDTVDNGNGSSNNGSSTTTSTAPATTVSDDEVTPTTTATTNNGTSGVVPASASLKPVVTTKTTTSDAKTLPQTDEDENGTALAVLGLSTLLMGSALYFGVSRRKHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR66</accession>
    <name>F9UR66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, YkoY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642722.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890219.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2549"/>
    <dbReference type="EnsemblBacteria" id="CCC79705">
        <property type="protein sequence ID" value="CCC79705"/>
        <property type="gene ID" value="lp_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2549"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2141"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070543_1_1_9"/>
    <dbReference type="OMA" id="IMFLDIV"/>
    <dbReference type="PhylomeDB" id="F9UR66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2197-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022493">
        <property type="entry name" value="CHP03716_TM_YkoY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03716">
        <property type="entry name" value="R_switched_YkoY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="29047" checksum="B97F7289B82DCC5F" modified="2011-10-19" version="1">MLHLIEQLYGPFFSATNWGNVITSANDWLIILSLAIIECLLSVDNAVVLAAQTQSLDNLQEREKSLFYGLWGAYIFRFLIIGIGTYLISFWEIKVLGAAYLGYLVYRYFSQPKNGAKVAQKPKQQRRFFGLSNFWSVVIQIEMMDIIFSIDSVLASLAISDNPVIVLIGGMIGIACMRGIAEVIMRLMRKIPELETMAYCLIVLIAIKLFISIPAIGWDIPATAFGGIVLVAFIITLLIHFWRRRRNEQCVEGKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ8</accession>
    <name>F9URJ8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 13">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 13">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 13">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">purM</name>
        <name evidence="16" type="ordered locus">lp_2722</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 13"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890351.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2722"/>
    <dbReference type="EnsemblBacteria" id="CCC79837">
        <property type="protein sequence ID" value="CCC79837"/>
        <property type="gene ID" value="lp_2722"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2722"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2277"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_9"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="PhylomeDB" id="F9URJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2328-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="14">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="15">
        <location>
            <begin position="167"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC79837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="35872" checksum="BD017C7C093C93EB" modified="2011-10-19" version="1">MSDAYKRAGVDINAGYDVLKTVKQMSGNQQLGAFGGAFPLSPDATANDPVLVAGTDGVGTKLLVAIAADQHTTIGIDLVAMCVNDILAQGATPQFFLDYLGLGHTDQKRVKAILTGVVAGCQQAHTALIGGETAEMPDMYGQDHYDLAGFAVGIANRADLLSPANVRAGDVLIGLPSNGLHSNGFSLVRDILFKQHDYQLTTVFDELGHDLQTELLRPTTIYVDAVQPLLQQKLVTSIAHITGGGLIENVARALPAGLSAHLELGQWPVPPIMTLLAELGGLTATDLRSTFNLGLGMVLIVHPDQVAAVTANLTANAQSYYRVGTVQTGTTPVVFEEAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL8</accession>
    <name>F9URL8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101902.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890371.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2744"/>
    <dbReference type="EnsemblBacteria" id="CCC79857">
        <property type="protein sequence ID" value="CCC79857"/>
        <property type="gene ID" value="lp_2744"/>
    </dbReference>
    <dbReference type="GeneID" id="57026117"/>
    <dbReference type="KEGG" id="lpl:lp_2744"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2297"/>
    <dbReference type="eggNOG" id="ENOG502ZHCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092380_0_0_9"/>
    <dbReference type="OMA" id="VTWISAI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2348-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="269" mass="30268" checksum="E62D4FA6D46D68D4" modified="2011-10-19" version="1">MSIKVRNTTRYLLTEQLKMTGWSVLALFVVFGILPLLFAVITGNIRQYSPLGNFASLSLGPLFFMLIFIVGSLTYDNFKLLIQNGISRQTYFQARVFALLMLSGLLVIINAIYYYGIHAPYLHWSTNTALMRTGYSLYSHALGNQVWLNILASLCFNWIFYIGVGLTGIACGTLLALFGKWAKTILIIGTPIIGMLIIWIMVIIMTRNQSNYNYTGLENFLKFIIGYPSHGEATTGYFNPTMPFITMLVGCGIIGGLAYLFNRKLRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR0</accession>
    <name>F9URR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890413.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2794"/>
    <dbReference type="EnsemblBacteria" id="CCC79899">
        <property type="protein sequence ID" value="CCC79899"/>
        <property type="gene ID" value="lp_2794"/>
    </dbReference>
    <dbReference type="GeneID" id="57026160"/>
    <dbReference type="KEGG" id="lpl:lp_2794"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2339"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_4_2_9"/>
    <dbReference type="OMA" id="ACFGSGD"/>
    <dbReference type="PhylomeDB" id="F9URR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2390-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="148" mass="16013" checksum="646EECFAC78B11AE" modified="2011-10-19" version="1">MATAKVIFATITGNNEDVADIITEKFEKLGVDVAKEEISQADATEFNDVDICVVVPYTYDEGALPEEGLDFYEDLQDLDLTGKIYGCAGSGDTFYDDDYCRAVTDFSNALKKAGATQGAKDVFVNLAPEADDVKALDAFTEQLVAKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR7</accession>
    <name>F9URR7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5 diketo-D-gluconic acid-like reductase NADP dependent (Promiscuous)</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890420.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2802"/>
    <dbReference type="EnsemblBacteria" id="CCC79906">
        <property type="protein sequence ID" value="CCC79906"/>
        <property type="gene ID" value="lp_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2802"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2346"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="OMA" id="DSAIMYR"/>
    <dbReference type="PhylomeDB" id="F9URR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2398-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="32258" checksum="DC693A522D398EE5" modified="2011-10-19" version="1">MTKTPTITLNDGRAIPAIGFGTFQIPDDGSTYQAVKEALVIGYRHIDTAVAYFNEDEVGQAIKDSGIPRDQIWVTSKLWLQDYGFDAASRAIDRSLTKLRLDYIDLYLIHQPYGDVPGAWQAMEAAQKAGKLKSIGVSNMTPTLWQKFVPQFETIPAVNQVEFNPYFQQQPLRQLLAAQDVKLEAWAPLGQGNQALFKEPIIQQLAIKYHKDAGQIILRFEHQEGVIVFPKSVHSARIKSNRDIFDFELTSTEMAQLRALDTGKGHHDPDAPGVSEQLLHAFDVHADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT3</accession>
    <name>F9URT3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine nucleosidase, inosine-uridine preferring</fullName>
            <ecNumber evidence="4">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890436.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2825"/>
    <dbReference type="EnsemblBacteria" id="CCC79922">
        <property type="protein sequence ID" value="CCC79922"/>
        <property type="gene ID" value="lp_2825"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2825"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2363"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_11_0_9"/>
    <dbReference type="OMA" id="HAPDIHG"/>
    <dbReference type="PhylomeDB" id="F9URT3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2419-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="326" mass="35449" checksum="C4FBFB987310712E" modified="2011-10-19" version="1">MNATRNVIIDCDPGIDDSLALLLALKSPALNVIGITIVCGNVPTHIGAENALKILDLADRLDIPVYLGANRPLEVAYTSAQDTHGDDGLGNSQIPAVTAVRPIQDAAGFIEETLIEAPDTSILALGPLTNIATVLQRDPHLFEQVDQFTLMGGSYRSHGNCSPVAEYNFWCDPDAAKVVFDLMPVPIQMVGLDVTRNIVLTPSLLTYIKDVNPAMGAFVEKITKFYFDFHWEYERVIGCVINDPLAVAGMLDPTILSGFESYTTVVTDGVARGQSIVDDHDFWHNTPNSQIMTKVDVVAFWRLFLTTVVGATDPDLTQVLHQLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9US34</accession>
    <name>F9US34_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaN</name>
        <name evidence="15" type="ordered locus">lp_0002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641629.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888095.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0002"/>
    <dbReference type="EnsemblBacteria" id="CCC77581">
        <property type="protein sequence ID" value="CCC77581"/>
        <property type="gene ID" value="lp_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="57026865"/>
    <dbReference type="KEGG" id="lpl:lp_0002"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_2_0_9"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="PhylomeDB" id="F9US34"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="136"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="253"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="379" mass="41521" checksum="13EA997B81E73717" modified="2011-10-19" version="1">MKFTINRSAFIKELNNVQRAISSKTTIPILTGLKLDVNTDAITLTGSDADISIETTIPASDDNNTLVVEDAGSIVLPARFFSEIVKKLPEDTMTVNVVDGFQTQITSGAASFTINGLDPENYPHLPEIDTTNTITLAGDVLKELIGQTVIAVSNQESRPILTGVHFILANGEFLAVATDSHRLSQRRIKLPEANNANYDVIIPGKSLTELSRMIGDNNPDVQMRLSENQVLFVLGNTSFYSRLLEGNYPDTSRLIPKESNTTVEISAPALSAAIERASLLSHESRNNVVRFSVNPTDKTITIFGNSPDVGEVTEQLQPTDLSGDELEISFNPDYMKEALRSFGQAMIKISFTMALRPFTLVPTEEGENFIQLITPVRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US48</accession>
    <name>F9US48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide ABC transporter,oligopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641642.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888109.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0018"/>
    <dbReference type="EnsemblBacteria" id="CCC77595">
        <property type="protein sequence ID" value="CCC77595"/>
        <property type="gene ID" value="lp_0018"/>
    </dbReference>
    <dbReference type="GeneID" id="57026880"/>
    <dbReference type="KEGG" id="lpl:lp_0018"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.16"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="AQDPYYN"/>
    <dbReference type="PhylomeDB" id="F9US48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-16-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388117" evidence="3">
        <location>
            <begin position="27"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="538" mass="59728" checksum="F6858605E3F6FEC6" modified="2011-10-19" version="1">MKKRIWISSIAIVALGLVLTGCGSQQSSQQKTLNVTATQSIATADPNKADDIASQAAIAQFMEGLYTTNQKGKVVPAIAKKVVKPTNNGKTYTFNLRHNAKWSNGKKVTAADFVYSVQRQVDPNTKSQEVGHVAEIKNATAITAGKKAVKTLGVKALGKYKLQITLQQRVPYFNYRLATEIYPLNKQFTEKYGNKYGTSAQRTLSNGPYVLKSWNGTNDTWKYVKNPYYYDRKQVRIKNIKVQTVKNNSTAENLFQSNEVQVTQITGTQVSAAEQGSLKSQMKVTKLNQLYFMLWNQKRSALQNTDLRRAVSYALNRQSLVKNVLKDGSVAATSLVPAGNTKNPTTGKDFNTDTGNLYPYSPAKAKQYWQKAQASLGKQKLTLQLLTNDNDINKSVAEYIQAAIEKNLSGVTVNVKSVPLTNEISTLSKGDFDFATLSWSSDFQDPVDFLNKASITNSVNFGKFNNAKYEQLISTITADKQSTKARYQTMQQAAKLVAQQQGVTPIYQTAAAHLISNKVGGVHFTLLRDALYRYAYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9US83</accession>
    <name>F9US83_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100863.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888144.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0063"/>
    <dbReference type="DNASU" id="1061282"/>
    <dbReference type="EnsemblBacteria" id="CCC77630">
        <property type="protein sequence ID" value="CCC77630"/>
        <property type="gene ID" value="lp_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0063"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.52"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532949_0_0_9"/>
    <dbReference type="OMA" id="VAISIWK"/>
    <dbReference type="PhylomeDB" id="F9US83"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-52-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="432"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="511" mass="57525" checksum="C37611EEBAED5762" modified="2011-10-19" version="1">MQLKPLLRQLATTFEVTVDPTFTHNPEVTHVQFVDPTEALASHRLYLSPDSSQLVQLTYSWHGHRQSVGLVNLGTGLTTIIAAQNQLLKLLMTLGQCLHHDVQIQAAINQLAIQAITADFDTTLAQAVRLLENPLAIIDLNGEILTRSHTTQLNGTSIHAAVETNRVGRWLLDHGFAPDTPDFLTQVYVAEDQLSAGPMLITPLANGTEPLGYLVMPALNKPLNDRQALLINSIGQVIAGSLVKNQIMPTAESQRDRLLNLLLTEHQGGTFADQFAEQHVQLPTAMVLIRCEPLADQAPMILQQRLQYLMMPRFKQVLVSTYQQQCVALIPISLVAYNQNQFKLTLQQITKQADCRLIVSQHYVNPEDTFAAYTVCERTAQLKTGRGRVIFCEDQFYNLALARVNHLEILPFFINPALRLLLAYDQQNHTELVPTLDVYLRATCNLTRTAKQLYVHPNTLRNRLHHITTLTGCDLRDAETCFKLAASFKLRQFLTQHQYQYRPDIPIPTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE7</accession>
    <name>F9USE7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="2">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tag2</name>
        <name evidence="2" type="ordered locus">lp_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102008.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3020"/>
    <dbReference type="EnsemblBacteria" id="CCC80077">
        <property type="protein sequence ID" value="CCC80077"/>
        <property type="gene ID" value="lp_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3020"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2523"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_3_0_9"/>
    <dbReference type="OMA" id="FEHEWGI"/>
    <dbReference type="PhylomeDB" id="F9USE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2571-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="214" mass="24850" checksum="8038429B1A13D099" modified="2011-10-19" version="1">MITNWFDDDPLFNRYYPYDAGYRYYFEHEWGIPVQRDEQLFEFLSLGGFAAGLNWAVVFNKRSAFSAAFDAWQIEVVAAYRSEQITNLLSNSAIIRNRRKIEAVIHNARLIQQIRTTQSFKDYLWQQLGHQQLIIQPQYYDELPRTTITGDRIAQHLQQVGFKFVGPVTINAWLVNTGFITARPDQLGIITTTPRPSSTMLPPRSPHQLGHFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF0</accession>
    <name>F9USF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase V, subunit UmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">umuC</name>
        <name evidence="3" type="ordered locus">lp_3023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102011.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890594.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3023"/>
    <dbReference type="EnsemblBacteria" id="CCC80080">
        <property type="protein sequence ID" value="CCC80080"/>
        <property type="gene ID" value="lp_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3023"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2526"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_5_1_9"/>
    <dbReference type="OMA" id="FWRVGKG"/>
    <dbReference type="PhylomeDB" id="F9USF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2574-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="506" mass="57425" checksum="2E97907858DB1CE1" modified="2011-10-19" version="1">MEQRTYMAIDLKSFYASVECVAHQLDPLNANLVVADTSRTDKTICLAVSPALKQFGVPGRPRLFQVEQRVATLNRARGRQTSYQAVRRHRSIYRDQLLKHANLGIDYRVVPPRMSYYIQKSAAIYDIYLRFIKPEHIHVYSIDEVFMDVTDYLSTFQVSPHALAKTMIHEIQAETGITATAGIGANLYLAKVAMDIVAKKIPADADGVRIAQMDEQQYRQYLWAHEPLTDFWRVGHGYAKRLAALGLNTMGDIARCSLGTLSDSHNEEQLYREFGKNAELLIDHAWGDESATIADIKNYHASEHGIYASQVLMRPYTYTEGQAVLRGMVNNLTLELVARHVVTDQLGIRIDYDANASSVGTHYQGAVTEDYYGRQVPKPAHTTVTLAQASASQHELGAAYQQFYQQVVNRQLMVRRVTVMANHLVDEQQVRRQPRYQQTNLFENPEVAQAQERDAQRKRERDGQLQRAILKLQRRSGNKNVVIRLADLKPSSTTIERNEQIGGHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG9</accession>
    <name>F9USG9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102018.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3047"/>
    <dbReference type="EnsemblBacteria" id="CCC80099">
        <property type="protein sequence ID" value="CCC80099"/>
        <property type="gene ID" value="lp_3047"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3047"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2546"/>
    <dbReference type="eggNOG" id="ENOG5034BQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154447_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2592-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="15350" checksum="3638DD0C9E05DBC2" modified="2011-10-19" version="1">MTTALFTNQVLTQATPATVRALLADPLNLPAWATAITTVKPTATGYVLQRSGSVFDQPEQLQVTVGADQVVYHSEGGQLGYEIVFTMTPLAERTAVQEEVSLTTTPPSWLPLPLVKPVMQRDFQRKLGQLATLAEEQPNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK1</accession>
    <name>F9USK1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lamR</name>
        <name evidence="6" type="ordered locus">lp_3087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3087"/>
    <dbReference type="EnsemblBacteria" id="CCC80131">
        <property type="protein sequence ID" value="CCC80131"/>
        <property type="gene ID" value="lp_3087"/>
    </dbReference>
    <dbReference type="GeneID" id="57026398"/>
    <dbReference type="KEGG" id="lpl:lp_3087"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2578"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="SERGRHQ"/>
    <dbReference type="PhylomeDB" id="F9USK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2624-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="28582" checksum="DCE731C042006DC4" modified="2011-10-19" version="1">MIKVYICEDDTKQLQTLQQLVSKVIIDRQLDMGFGLTSADPHEILAHVKSQQPTQAVFLLDIALNSDINGIQLASQIRDLGIRSKIIFVTTHTELSLTVFQYQVEALDFILKDFPDRLYERLNTVLRVAQERFKAEDNDQNSYIQIKIGETIRSLDVQHVLFFESSMSPHKIIVHLDDGELEYYGLLKDVPDLNSDFYRCHKSYVVNLTRIRSLDKRYRQLTMANGETVLCSAAASRYLVRQIGKNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ5</accession>
    <name>F9USQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890699.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3150"/>
    <dbReference type="EnsemblBacteria" id="CCC80185">
        <property type="protein sequence ID" value="CCC80185"/>
        <property type="gene ID" value="lp_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3150"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2633"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_0_9"/>
    <dbReference type="OMA" id="HDIGMAS"/>
    <dbReference type="PhylomeDB" id="F9USQ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2678-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="362" mass="39138" checksum="6F3DCE5A9330CDCC" modified="2011-10-19" version="1">MVKRYNSKKIEQLIYNIYKGYGFTEEESQEVAHMLIYTDLIGIESHGVQRMIMYDDFIRNGKIRVHNRPEVVKETDVSAVVDAHFGLGQLNGIYSMRLAIEKAKQHGIGIVTTRNSGHYGIAGYYANMAAEEGLIGLSSCNSRSAMLPTHATKALVGTNPIAFAMPANPNTFIFDAATTTVPQGKIEVYRKLGKDMPALWVAKDGETPVNSHNDTKDLDALRDLDSNVGLAPLGGVTEDTGSHKGFGLGVIVEVFTAILSMGNTSNEITPDDLSVGPCQSFVAIDPSIFGDKDAIIAKFSAYLQAIRDLPSVSGKPVIVAGDKEAAAYQDRSANGIEIDDKTLAEVTGIAKRLGIDYAQYVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS7</accession>
    <name>LARMN_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable fused nickel transport protein LarMN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Probable energy-coupling factor transporter substrate-capture protein LarMN</fullName>
            <shortName evidence="4">ECF transporter S component LarMN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">larMN</name>
        <name evidence="6" type="synonym">cbiM</name>
        <name evidence="6" type="ordered locus">lp_0102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably part of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May form an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, LarO), a transmembrane protein (T component, LarQ) and a fused possible substrate-capture protein (S component, LarMN) of unknown stoichiometry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced by L-lactate but not by a racemic mixture of DL-lactate. Makes part of the larR(MN)QO operon.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CbiM family. NikM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888172.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9USS7"/>
    <dbReference type="SMR" id="F9USS7"/>
    <dbReference type="STRING" id="220668.lp_0102"/>
    <dbReference type="EnsemblBacteria" id="CCC77658">
        <property type="protein sequence ID" value="CCC77658"/>
        <property type="gene ID" value="lp_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0102"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.82"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9USS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-80-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441649" description="Probable fused nickel transport protein LarMN">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="35166" checksum="F22A8092C9B3A6CC" modified="2011-10-19" version="1">MHIPDNYLSPATCGTLVTAMAPVWTVAVLKVKVQIKKHHETLPMLGIAASLAFLIMMFNLPIPGGTTAHAVGGTLLAVLIGPWAACLALTVTLLLQALLFGDGGILAFGANALNMAVIMPFVGYACYRLGQKWHHEKLGLAIGAYLGINMAALVAGIELGLQPILAHTASGAPLYCPYGLNITIPAMLTAHLLVAGWVEVVFTLLVFQFVKRVAPTNLYQTPTRRNQRPWIALLLGLAVLSPLGLLASNTAWGEWSPQELQQRLAQQHISTHAPQGMVHGFHFQALFSDYAIAGLPVSVGYILSAITAVLIFLLLIRGLQHETDTSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ3</accession>
    <name>F9USZ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mapB</name>
        <name evidence="7" type="ordered locus">lp_0181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641776.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888238.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0181"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77724">
        <property type="protein sequence ID" value="CCC77724"/>
        <property type="gene ID" value="lp_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="57027011"/>
    <dbReference type="KEGG" id="lpl:lp_0181"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.149"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_1_9"/>
    <dbReference type="OMA" id="YDEKFWQ"/>
    <dbReference type="PhylomeDB" id="F9USZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-146-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050082">
        <property type="term" value="F:maltose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="322"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="699"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="591"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="756" mass="86603" checksum="B31BB7FF6D1B4132" modified="2011-10-19" version="1">MKRIFEVDPWHVISHELVPTDKRLQESMTSIGNGYMGMRGMFEEHYSNDTLKGIYIGGVWYPDKTRVGWWKNGYPDYFGKVINSVNFIKVNITIDGDQVDLAKDTVSDFTLDLDMHTGILRRSFIITKGEKRVQFMIDRFVSVAQKELFDVHYSVHNLGAEPVQIGFISQIDADVFNEDANYDEQFWQVLDKSHAITGGSMFAETKPNNFGTPRFTLGMQMLHETAFRGINAPETEKAVTNIFRGTLAPDETKNFEKRVLVVTSRDYADMAAMRTGLAELSETVSTQSYEDLRQAHVDGWAKRWQLSDVLIDGDDAAQQGIRFNLFQLFSTYYGEDKRLNLGPKGFTGEKYGGATYWDTEAFGVPFYLSLAKPEVTENLLEYRYNQLAGAFHNAKMQGLAGALYPMVTFNGIECHNEWEITFEEIHRNGSIAYAIFNYTRYTGDEIYLKTKGIDVLTGISRFWADRVHFSERKQQYMIHGVTGPNEYENNVNNNWYTNFMARWTLEYTLASLKKVDAAKRAALQITDAELAKWQDIVDRMYFPYDEKLGIFVQQDGFLDKDVKPVSSIPADQRPINQHWSWDHILRSPYIKQADVLQGIYYFMDKFTAEQKKRNFDFYEPLTVHESSLSPAVHAILAADLHYEDKAVEMYERTARLDLDNYNNDTVDGLHITSMTGSWLAIVQGFAGMRVKDDTLAFAPFVPKAWTHYQFHVNFRGRLIKVDVDQQGTTVELVSGEPLTIELNGQAIEVASTVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT33</accession>
    <name>F9UT33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription regulator, BglG family, mannitol operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mtlR</name>
        <name evidence="7" type="ordered locus">lp_0231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888278.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0231"/>
    <dbReference type="EnsemblBacteria" id="CCC77764">
        <property type="protein sequence ID" value="CCC77764"/>
        <property type="gene ID" value="lp_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="57027054"/>
    <dbReference type="KEGG" id="lpl:lp_0231"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.192"/>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_2_0_9"/>
    <dbReference type="OMA" id="QKIFQAY"/>
    <dbReference type="PhylomeDB" id="F9UT33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-186-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="537"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="691" mass="78021" checksum="3FFEBABA832944EF" modified="2011-10-19" version="1">MVKFTQRQDELLQLLLANPAGLSMSQIETGLNSSRRTIYREFSNLELVLANADLKIVNEKHHFQLSGSQTALAKFQSQLTAERKIAPAFDSQTRQNALACRLLMTGHSVKLKELALDFDVSVATISNDLTALATPFADYDLSIERLKSRGIQVAGTEGSIRNLFATILNNEINDYEFFKTIGKLNQGLAISASDEQSYFLNLLDAQTLIICYQAVRSLKKKYFSSVPDGQLQQLIITLTTGVMRLQHERRVTYLRGINRDDFLKYQRIALAIMTQLPAEIKTVVTGAEIDFLAQQIKGLTFRIDQDASLSNYDLQLTYRVKKFIDAVATNFNWSFGTDDRLLNNLTAHMQIALQRNGVNGPVPPTTELQEVREQYPKLYSAVVRGFATIFKDQDFTTDELTYLLIHFASTYEQQLSHQALKVLVLCPNGMTTARILKTRLMRLVPEITAIEVARIGNLGQVNLQDFDMILSTTTLPGFKLNYRVVSPLLLENEVTALREYIHQYFPSTKVIDSPVDEPTKINLDFDTVYQQMTIAKQILDRFTITPIRNDDETVAEMLVKITRHIDSNLIHDPLEVAGRLLHRLGLAPVGIPNTNLALVHTLSQEVTAPYCAIFELDQPLPFKSMDNQSIRLQRIVLMLGPANISDFENRLMGKLSALVIESQANTQTFMTGDRQQLYQLISKAFLNELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT51</accession>
    <name>F9UT51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxygluconate kinase</fullName>
            <ecNumber evidence="2">2.7.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdgK</name>
        <name evidence="2" type="ordered locus">lp_0253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.45" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888296.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0253"/>
    <dbReference type="DNASU" id="1061208"/>
    <dbReference type="EnsemblBacteria" id="CCC77782">
        <property type="protein sequence ID" value="CCC77782"/>
        <property type="gene ID" value="lp_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0253"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.209"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_9"/>
    <dbReference type="OMA" id="HYEEMLG"/>
    <dbReference type="PhylomeDB" id="F9UT51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-204-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008673">
        <property type="term" value="F:2-dehydro-3-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="38086" checksum="58857E207424BE01" modified="2011-10-19" version="1">MKILAFGEVLLRMTVPEHLMLTQTDELRMSTVGTGVNLLSSLTHFGYRTRLLSRLPDNALGQRAAGELRRYGIQDDYVTFGGQHMGAYFVELGYGSRPERVTYQDRLSSAFCQQPPDDQEIAAALVGCQFVHICGITLSLTAPVRQAALRLAQQAHANGQRVCFDFNYRQQLNTGVAHETLKARYQEILPYVDIVFGSKRDLTALLDYPDDEDRTQSANRESEAALYEQFVRDYHIDYFAGSYRYQIGQQKWFAGFSYQHQQLVVGKARPLMILDRIGSGDAFASGIITALIEGWSLQKTTDFAIATAILAQATVNDAPEFTKEMVLADMASDGQLELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT92</accession>
    <name>F9UT92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890724.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3179"/>
    <dbReference type="EnsemblBacteria" id="CCC80210">
        <property type="protein sequence ID" value="CCC80210"/>
        <property type="gene ID" value="lp_3179"/>
    </dbReference>
    <dbReference type="GeneID" id="57026472"/>
    <dbReference type="KEGG" id="lpl:lp_3179"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2658"/>
    <dbReference type="eggNOG" id="ENOG5032ZVG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138399_0_0_9"/>
    <dbReference type="OMA" id="MECNDEL"/>
    <dbReference type="PhylomeDB" id="F9UT92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2698-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="144" mass="16648" checksum="89D502E4880FDCF5" modified="2011-10-19" version="1">MVERATKELFNEIKHASEADQFMTNMATSFIRTNPAEYLAELIQIKHVTKSQVIRRANLTPSIGYQYFDGKRRPNRARIIALGFGFQLTLTELNTMLKRTGYAVLYAKDEWDALVIFALSQRFDLNRTDELLYQYGLGTITDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE6</accession>
    <name>F9UTE6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="3" type="ordered locus">lp_3247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643467.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890778.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3247"/>
    <dbReference type="EnsemblBacteria" id="CCC80264">
        <property type="protein sequence ID" value="CCC80264"/>
        <property type="gene ID" value="lp_3247"/>
    </dbReference>
    <dbReference type="GeneID" id="57026528"/>
    <dbReference type="GeneID" id="66450779"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="160" mass="18130" checksum="F37A76FD356A5819" modified="2011-10-19" version="1">MAEDMLTQALQQLKDHKIRVTPQRQIILNYLITHHNHPSVETIYQELATQLPNLSLATVYNTLKLFVDLGIVIELQNGDAGTHYDFFGRPHYHVVCENCGKITDVFEPDLRSVEAKAAELSGYLVTGHNMEVYGLCPDCQKLLNVTKTADLKRLKLTHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE7</accession>
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        <submittedName>
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890779.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80265">
        <property type="protein sequence ID" value="CCC80265"/>
        <property type="gene ID" value="lp_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3248"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2713"/>
    <dbReference type="eggNOG" id="ENOG503407K">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168863_0_0_9"/>
    <dbReference type="OMA" id="YIYFTAY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2753-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015046">
        <property type="entry name" value="LciA_Immunity-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08951">
        <property type="entry name" value="EntA_Immun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0079">Bacteriocin immunity</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="118" mass="13329" checksum="DD4920A092B7D43B" modified="2011-10-19" version="1">MQRESELRQQAQEAIKGLIVRLSGWSDQSGDLLDIIDVLMQVDKKITTTKNPEALVNRLVNYIRSVAIKGRLHFPDEEEKLMIDLGIIGQKAGLNGAYMADFSDKSQFYGILEEVPQH</sequence>
</entry>
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    <accession>F9UTF1</accession>
    <name>F9UTF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Murein hydrolase export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lrgA</name>
        <name evidence="7" type="ordered locus">lp_3254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3254"/>
    <dbReference type="EnsemblBacteria" id="CCC80269">
        <property type="protein sequence ID" value="CCC80269"/>
        <property type="gene ID" value="lp_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3254"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2717"/>
    <dbReference type="eggNOG" id="COG1380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113736_0_0_9"/>
    <dbReference type="OMA" id="TGWMTQL"/>
    <dbReference type="PhylomeDB" id="F9UTF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2757-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15445" checksum="4B7C7C38C9FE8FED" modified="2011-10-19" version="1">MKKGAFITQIVIYGLILLASSLIANLVNKIWPAFPMPTPLIGMILLYLLLTFKVVKLEQVAGVSNFFVQFISLIFIPSGIALVTKLDVLKAEGVQIVIVIIVSTLMLLLFTAGIAWVLIQVKEWFIARRTNSNVELEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF2</accession>
    <name>F9UTF2_LACPL</name>
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        <submittedName>
            <fullName evidence="6">Murein hydrolase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lrgB</name>
        <name evidence="6" type="ordered locus">lp_3255</name>
    </gene>
    <organism evidence="6 7">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3255"/>
    <dbReference type="EnsemblBacteria" id="CCC80270">
        <property type="protein sequence ID" value="CCC80270"/>
        <property type="gene ID" value="lp_3255"/>
    </dbReference>
    <dbReference type="GeneID" id="57026534"/>
    <dbReference type="KEGG" id="lpl:lp_3255"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2718"/>
    <dbReference type="eggNOG" id="COG1346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082099_1_0_9"/>
    <dbReference type="OMA" id="PLHTAYA"/>
    <dbReference type="PhylomeDB" id="F9UTF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2758-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="26"/>
        </location>
    </feature>
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            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="102"/>
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        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="25607" checksum="E7F579084DF04924" modified="2011-10-19" version="1">MSYLLNNPFFGIGLSILVYGIGEYLYHKTNRFVLFQPLFFGMLLGIGLLVLIASILKAPVQKVYEAYQVGGDWLFWFVAPATVSFAVPLYKRNDIFKKHWDVIVIALAIGLGLSLFGIYGISRLLGLTDAALGAMLVQAATTAIALPVAESVGGDQAIAAFAVILNSVLIYALGDHFIRWFKLHKNPLGAGLGFGIAGNAVGATKAIEVSEAAGATGAIAFVIAGILVNFMVPGFAQLIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890810.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80296">
        <property type="protein sequence ID" value="CCC80296"/>
        <property type="gene ID" value="lp_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3290"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2746"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_2_9"/>
    <dbReference type="OMA" id="SGWENDH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2784-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="24279" checksum="93D2370A00C5DD13" modified="2011-10-19" version="1">MKFSEKLKVCRKHAQLTQSQVAEQLHVSRKTISGWENDHSFPDVGSLVQLSDIYDVRLDDLMRDDHLLAYYKEAEQLHQKSRKWVVVSYRCNFLLLVLGYIDYLRPFGIRTFLVPFLVLVNAMVLLSYFSDWQRFKSGKLRVGIVITVFIAFIAEILINTIVPSYLNELAHAVDDGPAAIIGEVAGRLLVTSILILSLVLAIFLKPKQRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ7</accession>
    <name>F9UTJ7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890829.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3316"/>
    <dbReference type="EnsemblBacteria" id="CCC80315">
        <property type="protein sequence ID" value="CCC80315"/>
        <property type="gene ID" value="lp_3316"/>
    </dbReference>
    <dbReference type="GeneID" id="57026579"/>
    <dbReference type="KEGG" id="lpl:lp_3316"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2766"/>
    <dbReference type="eggNOG" id="COG2151">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_0_9"/>
    <dbReference type="OMA" id="PATHYLQ"/>
    <dbReference type="PhylomeDB" id="F9UTJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2806-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11552" checksum="0D4191AE476BC931" modified="2011-10-19" version="1">MTTTFKDRAFEALGHVIDPELGIDLVNLGLIYDAQLTAEGTAEITMTLTIAGCPLTEWLAKDIHDELIKLPEVNNIEIEIVWEPAWNESMMSREARMELGIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR2</accession>
    <name>F9UTR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="COG1199">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="180"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="789" mass="90098" checksum="A4E92D1B9B1967C0" modified="2011-10-19" version="1">MATKIGIRQLVEFVLRQGDLNEIKNSQNTALNGAKIHRQLQSSRGEDYDSEVYLKKIVTMNDTDYIITGRADGIQLNDDGALIEEIKTSDQVFEDLSTNTLTLYWGQIKVYGYLLLQEHPDLEQVTLQLTYFQVINEKITKTQQILHRGELDAFFHDLITEYEYWLTLRADLRRQRNASIEDLPFPFPAFRPGQHELAGAVYKTIRLQKRLFVEAPTGTGKTISTLFPAIKAMGEDVIERLFYLTAKQSTRHVAEEAVTLMSHDGLKLKSITLTAKDQIRFPEEQDVLPEDNPYMIGYYDRLKPALKDLLTHEDQITRSVIEQYARKHTVDPFEFSLDTSLFCDVIICDYNYLFDPLVYLQRFFSERDDDNFFLVDEVHNLVSRSRDMYSAAVSDQPISALLKLAKPDKSQPSDDLQRELKKVRRSFTRISKTLIDDQVTEQVLPDPPDKLLRTLRTFNEFVTDWLAQQKPGPLLDAVRDYFFACLTFVKIGDLYDGSYQTRFVLDGHHLTIKELCLDPSDFLNRSLELGSGAVLFSATLTPMAYYQRVLGGEANSLAYQLPSPFPPKHQAILVTQYVQTTYHERERNVPRIIASLHAMLTAKRGNYLVFFPSYGYLLQIKTAFEAAYPDVATTAQASTMDATARQTFLNQFQSAPSQTLLGFCVLGGIFSEGIDLRGDRLIGVAIVSVGLPGINPETNLIRDYYDHQNGLGFAYAYQLPGMNNVLQAAGRLIRSAKDTGIVLLLDQRFASRRYTDLFPAHWQYYQTIQSVPQLEATIANFWHQMEVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW3</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0366"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="148" mass="16485" checksum="E212E058E4A843ED" modified="2011-10-19" version="1">MATIHLYLASTNHQSTNITATTPAAWVVILRYADHQKALNDGGYGHTETSLALSALTTALTTLKRHDLPVHIHTTTEQVAAVISEQRYLSWRQNNWDVPEADQPDLPQWQTLIPIIEKFPNLTITYHPVDDPAMTTATTTLTAVMTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW6</accession>
    <name>F9UTW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione reductase</fullName>
            <ecNumber evidence="7">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gshR1</name>
        <name evidence="7" type="ordered locus">lp_0369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646444.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0369"/>
    <dbReference type="EnsemblBacteria" id="CCC77886">
        <property type="protein sequence ID" value="CCC77886"/>
        <property type="gene ID" value="lp_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0369"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.313"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_0_9"/>
    <dbReference type="OMA" id="CFDYVKP"/>
    <dbReference type="PhylomeDB" id="F9UTW6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-308-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="5">
        <location>
            <begin position="334"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="443" mass="47281" checksum="AD1C4A35610741D5" modified="2011-10-19" version="1">MAEQYDVVVIGGGPAGNAMASGLKAQGKTVLIVEADLWGGTCPNRGCDPKKILLSAVEARQAAQHLQGQGLIGAPKIDWPALMAHKRGYTDGINDGTLNGLTGQDIATLHGQAHFQSDNQLAVGDRVVSATDYVIATGQRPAILPITGHEYFKTSTDFLDLDQMPKRVTFVGGGYVGFELATIANAAGADVHVIHHNDRPLKAFDADLVKDLMAAMTADGITFDLNTDVQAITKTATGLQLTADNFELTTDLVISSAGRIPNADQLGLANVGVTFDRHGIQVNDHLQTANPHIYAIGDVSDTPVPKLTPVAGFEARYLVGELTHPGAAIKYPVVPTQVFAAPKLAQVGISAAVATEHPDEYRVNTLDMTKWFTYYRFGAQQAQAKVVVAKASGQVVGATLLSDVADEMINYFTLLIEKHVTLPDLQRLVLAYPTPASDLQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY7</accession>
    <name>F9UTY7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888421.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0396"/>
    <dbReference type="EnsemblBacteria" id="CCC77907">
        <property type="protein sequence ID" value="CCC77907"/>
        <property type="gene ID" value="lp_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="57024206"/>
    <dbReference type="GeneID" id="66448481"/>
    <dbReference type="KEGG" id="lpl:lp_0396"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.329"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="OMA" id="SFSIRHD"/>
    <dbReference type="PhylomeDB" id="F9UTY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-330-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="33220" checksum="D50328DEF652747B" modified="2011-10-19" version="1">MKILHETVQTIPRLPFKYYEHDPLTDINVAPHWHQGIELNYLVSGTTLKFVTDGQTNEYRPGDLWTTNRRVVHSASGPTEVDWVEFGIIIDDDFLQTQIPASANWQLTLNGAASSKTHPQAYADVRQQLVTIHDLLTTPTTDLLRLQILSHFYQLLVTLGQTFTVPLTATTVSPNLTLTDTVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQAYARYHRIDTSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU21</accession>
    <name>F9UU21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888455.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0435"/>
    <dbReference type="EnsemblBacteria" id="CCC77941">
        <property type="protein sequence ID" value="CCC77941"/>
        <property type="gene ID" value="lp_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0435"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.355"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_1_9"/>
    <dbReference type="OMA" id="NDIAFNY"/>
    <dbReference type="PhylomeDB" id="F9UU21"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-362-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="236" mass="26693" checksum="B0139880398F92AF" modified="2011-10-19" version="1">MYQAIAQAIIKSIMADEYPTKLPTEKVLMAQYNASRNTIRKAIDVVFRHGLLRRVQGSGNFIIKQPQNTKKVLNLSIGFDQSAMVDGGPLVSKVVTFDKVTADETLAQQGNIALGDEVYRVVRLRYLNDILYDLEESYFPRTVVPFLSSESVQHSIFAFLREAYGITGSTTENYVHQVRVDAQRAELIGCPDGDKTLCLEAINYLANGTVFNFSRTFFVYPDLELYYHTENIDLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB6</accession>
    <name>F9UUB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645582.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3440"/>
    <dbReference type="EnsemblBacteria" id="CCC80418">
        <property type="protein sequence ID" value="CCC80418"/>
        <property type="gene ID" value="lp_3440"/>
    </dbReference>
    <dbReference type="GeneID" id="57026664"/>
    <dbReference type="KEGG" id="lpl:lp_3440"/>
    <dbReference type="eggNOG" id="ENOG5030AC8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2807013_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2906-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7811" checksum="D9BF8658FAC9618B" modified="2011-10-19" version="1">MAISDIVMWTFVFIIATGFVTVISTAVLLKRAKRAPKDAEQSHSDDDDDWKKDDWNHDDWKKGDWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD6</accession>
    <name>F9UUD6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lacA</name>
        <name evidence="12" type="ordered locus">lp_3469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUD6"/>
    <dbReference type="STRING" id="220668.lp_3469"/>
    <dbReference type="CAZy" id="GH42">
        <property type="family name" value="Glycoside Hydrolase Family 42"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80438">
        <property type="protein sequence ID" value="CCC80438"/>
        <property type="gene ID" value="lp_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3469"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2886"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_9"/>
    <dbReference type="OMA" id="ITTNFMA"/>
    <dbReference type="PhylomeDB" id="F9UUD6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2926-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="15"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="407"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="624"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="683" mass="78066" checksum="EB8417821CF5597A" modified="2011-10-19" version="1">MSNPLKTTEFLHGGDYNPDQWLDQPEVIKQDFKAFKAAKLNTVTLGIFAWDKLEPAEGQYDFSWLDQIFDRAEAQGTKIILSTPSGARPRWLAEKYPEVLRVNEHGQRNQFGERHNHCYTSPVYREKVQMINQKLAERYGQRPSLLLWHISNEYGGACYCDLCQQAFRHWVQKKYQTLTNLNHAYCGAFWSHDYTSWDQVQAPSPLGDTNVMGLNLDWHRFVTDRTIDFFDNEIKPLRALTPNIPVTANFMGGNPSESHVFYDLDYQKFAKHVDIVSWDSYPNWSNGYESTAHLAMKTALMNDVMRSLKHDNYLIMESTPSQVNWHPYNRAKRPGMHEMGSLQQVAHGADSVLYFQLHQSLGASEMFHGAVIANHRGSNSRAFKDVQKVGQDLQSLQAAHGTTRTAAKVAIVFDYDNMWGLDDARNYANETKKYWRTIQEHYQYFWKHDIPVEIIATTDDLTAYDLVIDPMHFMMSAQFATKLKAYVQQGGHLIGTYITGVVDHDFLAYQGDGLADLEATYGIKVQETDTLYPQQHNALTAYHQAYQVNDYCDVVETTTAQVLGTYQKDFYAGTPAVTVNQLGQGAAYYLAARTDTDFLDAFYERLATSLALKPALPVIKANAKVSIQVRENATTRYYFVINFSHRPTTVTLEVPLRQIFENQVVSGKQDLASYGVQVYMMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE3</accession>
    <name>F9UUE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell filamentation protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fic</name>
        <name evidence="2" type="ordered locus">lp_3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102179.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890959.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUE3"/>
    <dbReference type="STRING" id="220668.lp_3477"/>
    <dbReference type="DNASU" id="1063402"/>
    <dbReference type="EnsemblBacteria" id="CCC80445">
        <property type="protein sequence ID" value="CCC80445"/>
        <property type="gene ID" value="lp_3477"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3477"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2893"/>
    <dbReference type="eggNOG" id="COG2184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080158_2_0_9"/>
    <dbReference type="OMA" id="FCHFEYI"/>
    <dbReference type="PhylomeDB" id="F9UUE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2933-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="199" mass="22966" checksum="49DFDAA71DF49028" modified="2011-10-19" version="1">MRKVWADYLQPNGILKNRLGITEAATLQKIEYKVSTQRQQQLSRNHYLLPDSHQLTGRQIGELKLINGFLLGEIYDWAGHYREVDFNKTANGVVTFFHPVALFGNAEMDIQRQLDNFAMLPNDREQLAQALGQVVTEINMFHPFREGNGRTTRLFTEVLAWQHGFDINYTQAQQDAYMQASIQDDAEMMAQVFLEVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG6</accession>
    <name>F9UUG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890982.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3500"/>
    <dbReference type="EnsemblBacteria" id="CCC80468">
        <property type="protein sequence ID" value="CCC80468"/>
        <property type="gene ID" value="lp_3500"/>
    </dbReference>
    <dbReference type="GeneID" id="57026713"/>
    <dbReference type="KEGG" id="lpl:lp_3500"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2916"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_9"/>
    <dbReference type="OMA" id="QFSMKGK"/>
    <dbReference type="PhylomeDB" id="F9UUG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2956-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="279" mass="30726" checksum="5BF30AA8A1573072" modified="2011-10-19" version="1">MNNNWLGLTDKVVAITGAVGGMGTKFCEEFAKQGAKIVLIDMIADKTEAYAKKLTEKYGVETLAVKCNTTNEEEVDAAVKAVTDKFGEVDVLVNTAAILRFSPLEDLRLDEWQAALNVNLTGYFLMSQRFGRVMIQQKHGAMVHISTVASRYPETYSGAYSTTKAAVNMMSKQMAAEWGQYGVRSNCVLPCLVKTPLSENFYSDPKVEEGRERLVASRRIGTLDDIANTVLFMASDRSDYTNGGEVTVDGGLNMMISDMIPKPGGRRQYAIDHHQPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI1</accession>
    <name>F9UUI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cblA3</name>
        <name evidence="3" type="ordered locus">lp_3517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890997.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3517"/>
    <dbReference type="EnsemblBacteria" id="CCC80483">
        <property type="protein sequence ID" value="CCC80483"/>
        <property type="gene ID" value="lp_3517"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3517"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2931"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_9"/>
    <dbReference type="OMA" id="FGYTRWN"/>
    <dbReference type="PhylomeDB" id="F9UUI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2971-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="387" mass="44206" checksum="644EE32A41196BE1" modified="2011-10-19" version="1">MQYDFNKVINRRGTYSTQWDYIQDRFGRSDILPFSISDTDFPVPVGVQEALEQRIKHPIYGYTRWNNEDYKNSIINWFSSQNQVTINPDWILYSPSVVFSIATFIRMKSAVGESVAVFTPMYDAFYHVIEDNQRVLAPVRLGSAQQDYSIDWDTLKAVLKQTATKILLLTNPHNPTGKVFSDDELKHIVALCQQYNVFIISDDIHKDIVYQKAAYTPVTEFTTKNVVLCCSATKTFNTPGLIGAYLFEPEAELREMFLCELKQKNALSSASILGIESQMAAYNTGSDYLVQLITYLQNNFDYLSTFLKSQLPEIRFKQPEATYLAWMDVSQLGLTAEKLQDKLVNTGRVGIMSGTTYGDSHYLRMNIACPISKLQEGLKRMEYGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK2</accession>
    <name>F9UUK2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system, ascorbate-specific EIIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891018.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3540"/>
    <dbReference type="EnsemblBacteria" id="CCC80504">
        <property type="protein sequence ID" value="CCC80504"/>
        <property type="gene ID" value="lp_3540"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3540"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2951"/>
    <dbReference type="eggNOG" id="COG3037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031784_0_1_9"/>
    <dbReference type="OMA" id="ARLTPWK"/>
    <dbReference type="PhylomeDB" id="F9UUK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2992-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="456" mass="47946" checksum="B284A7360137ED6E" modified="2011-10-19" version="1">MKTVLNLFVGIVTQPSILVALIAMLGLLLQKKKSTEVVQGTIKTFAGFLVLTGGAGILQNALSPFASMFKFALHVQGVVPSNEAVVAIALVKYGSTTALIMLAGMIVNILLARFTRFKYIFLTGQAMLYVSCLTAVILVSANIGTGWQTIVLGGLFEGTLLTVTPALTQPFMRKITGGDDVAMGHTGNIGYALSGLMGKWFGNAEKSTEDLEIPKSLGFLRDSTVSITILMGIVYIILAIVTGPAYIESKLSGGTNYIVYALVQAGTFAAGFVVVLQGVRMILAEIVPAFQGIATKLVPNSKPALDVPIIFPYAPNAVLLGFFVSFIVGTLSMFIMIALGTTVIIPGVVGHFFCGAAAAIYGNSTGGRRGAIIGATVNSLLISWLPLFILPVLGSLKLAASTFADTDYLVPGILLGKLGSYGSVAVITGIILFTIIVILCSIFLTRRAKRMTDGTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P59389</accession>
    <accession>F9UPD0</accession>
    <name>PYRR2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Bifunctional protein PyrR 2</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Pyrimidine operon regulatory protein 2</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Uracil phosphoribosyltransferase 2</fullName>
                <shortName>UPRTase 2</shortName>
                <ecNumber>2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="primary">pyrR2</name>
        <name type="ordered locus">lp_1782</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59389"/>
    <dbReference type="SMR" id="P59389"/>
    <dbReference type="STRING" id="220668.lp_1782"/>
    <dbReference type="EnsemblBacteria" id="CCC79069">
        <property type="protein sequence ID" value="CCC79069"/>
        <property type="gene ID" value="lp_1782"/>
    </dbReference>
    <dbReference type="GeneID" id="57025395"/>
    <dbReference type="KEGG" id="lpl:lp_1782"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1503"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_9"/>
    <dbReference type="OMA" id="VRITYEI"/>
    <dbReference type="PhylomeDB" id="P59389"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1532-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000183042" description="Bifunctional protein PyrR 2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="174" mass="19303" checksum="0547E7286C395B41" modified="2003-03-25" version="1">MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAIPVGELDITAFRDDQPLDQARLSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGGRPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVTVNEIDGHDGIEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH8</accession>
    <name>Q6LWH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS102</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377165">
        <property type="protein sequence ID" value="CAG17830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133714.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17830">
        <property type="protein sequence ID" value="CAG17830"/>
        <property type="gene ID" value="CAG17830"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17830"/>
    <dbReference type="HOGENOM" id="CLU_2807092_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3131-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS102"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7309" checksum="844989FEF4160D0C" modified="2004-07-05" version="1">MTAIVRRHWARGNKGLFPAHQALGFVQSINSLKPPRGANIACKALQAPLSRFTVDRQLNSSLLAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWI1</accession>
    <name>Q6LWI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS101</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377164">
        <property type="protein sequence ID" value="CAG17827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133710.1">
        <property type="nucleotide sequence ID" value="NC_006375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17827">
        <property type="protein sequence ID" value="CAG17827"/>
        <property type="gene ID" value="CAG17827"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17827"/>
    <dbReference type="HOGENOM" id="CLU_2935831_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3127-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS101"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="60" mass="6634" checksum="CF4ACB7FC8543160" modified="2004-07-05" version="1">MAESQSSLNFAFLPHGECGVSLSGSSRSIMRSSWHSLDWVRGVSARGLRNWSILTSFFLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SD8</accession>
    <accession>F9UUF9</accession>
    <name>AROD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name type="ordered locus">lp_3493</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102187.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SD8"/>
    <dbReference type="SMR" id="Q88SD8"/>
    <dbReference type="STRING" id="220668.lp_3493"/>
    <dbReference type="EnsemblBacteria" id="CCC80461">
        <property type="protein sequence ID" value="CCC80461"/>
        <property type="gene ID" value="lp_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3493"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2909"/>
    <dbReference type="eggNOG" id="COG0710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064444_0_0_9"/>
    <dbReference type="OMA" id="ATMAMGE"/>
    <dbReference type="PhylomeDB" id="Q88SD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2949-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000138798" description="3-dehydroquinate dehydratase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <sequence length="252" mass="27216" checksum="584337A6FD3058FE" modified="2003-06-01" version="1">MQPAIKLRNIELGSCRPKLAVPITGTTINDILAATTPILAAQPDVVEWRIDFFKDVTNPEQLKSAGQQLRQALGDIALLTTFRTKGEGGELALSDTEYFKLCETVLDGGFTDALDVERYHDEQAVKQIVAAAHEHQVVVIMSNHDFDKTPAVAEIVKRLTSMVDYGADVAKMAVMPQSVEDVLTLLTATNIARQTLPQPVITMSMGDLGKVSRLAGEVFGSCLSFATVGAASAPGQIALENLRPELEDLKLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88T16</accession>
    <accession>F9UTA2</accession>
    <name>PRSA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Foldase protein PrsA 2</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prsA2</name>
        <name type="synonym">prtM2</name>
        <name type="ordered locus">lp_3193</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PrsA family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890734.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88T16"/>
    <dbReference type="SMR" id="Q88T16"/>
    <dbReference type="STRING" id="220668.lp_3193"/>
    <dbReference type="DNASU" id="1061958"/>
    <dbReference type="EnsemblBacteria" id="CCC80220">
        <property type="protein sequence ID" value="CCC80220"/>
        <property type="gene ID" value="lp_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3193"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2668"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_6_1_9"/>
    <dbReference type="OMA" id="YHMILER"/>
    <dbReference type="PhylomeDB" id="Q88T16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2708-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01145">
        <property type="entry name" value="Foldase_PrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023059">
        <property type="entry name" value="Foldase_PrsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000029308" description="Foldase protein PrsA 2">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="34308" checksum="C83BB1BF5CAEF8EB" modified="2003-06-01" version="1" precursor="true">MKYRLIGVGASLVVAVMLTGCQAKATTLVKSDAGQVTQAEVFKQIENQATTQQAVQELTLNKVLNQRYHVSQAEVTAKLKAFKRQAGANYHMILERNHVTEPRLKSQIKANLLMEKAVSAKYPVTKAQLKKARAAYMPMTTVQHIATTNEKQAQKIIAELNAGASFDSQVRKYQNNRQAHTTAGKLAQFDSYNQTLAPAIVQATAKLRVGHYVTKPVKTVMATADTKDKPTYEIINVVSRRSKTAAVTDDSGKQIDVTNYLREKIQQQRMMDKQTQVATIRSVFKAAHVKVVDAHFAPAFNDYLTTQNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V04</accession>
    <accession>F9UQK2</accession>
    <name>QUEA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="1">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queA</name>
        <name type="ordered locus">lp_2285</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V04"/>
    <dbReference type="SMR" id="Q88V04"/>
    <dbReference type="STRING" id="220668.lp_2285"/>
    <dbReference type="EnsemblBacteria" id="CCC79491">
        <property type="protein sequence ID" value="CCC79491"/>
        <property type="gene ID" value="lp_2285"/>
    </dbReference>
    <dbReference type="GeneID" id="57025827"/>
    <dbReference type="KEGG" id="lpl:lp_2285"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1933"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_9"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="PhylomeDB" id="Q88V04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1975-MON"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000165412" description="S-adenosylmethionine:tRNA ribosyltransferase-isomerase">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <sequence length="344" mass="38987" checksum="07CB5D50BEF4C877" modified="2003-06-01" version="1">MSLTLEDFDYDLPHELIAQTPIKKRDSSRLLELDRQTGEMQDKHFYDIIDQLNPGDAVVMNNSRVMPARLYGVKPETGGHAEVLLLHNTEGDEWETLMKPAKRAKVGTVISFGDGKLTATVTAEKEDGIRMIEFHYDGIFMEILESLGETPLPPYIKEKLDDPDRYQTVYAKENGSAAAPTAGLHWTKELLQKVQDKGIKLVYLTLHVGLGTFRPVEEDNIDDHKMHSEFYRLDEDAAKTLNEVRQNGGRIIATGTTSIRTLETIGSKFDGEIKPDSGWTDIFIKPGYQWKVVDAFITNFHLPKSTLVMLVAAFTGRDMILKAYQHAIDEKYRFFSFGDAMFIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VX7</accession>
    <accession>F9UPM7</accession>
    <name>CLPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">clpB</name>
        <name type="ordered locus">lp_1903</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101584.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889680.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VX7"/>
    <dbReference type="SMR" id="Q88VX7"/>
    <dbReference type="STRING" id="220668.lp_1903"/>
    <dbReference type="EnsemblBacteria" id="CCC79166">
        <property type="protein sequence ID" value="CCC79166"/>
        <property type="gene ID" value="lp_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1903"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1603"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_9"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="PhylomeDB" id="Q88VX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1628-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000191132" description="Chaperone protein ClpB">
        <location>
            <begin position="1"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 2" evidence="2">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD1" evidence="1">
        <location>
            <begin position="161"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="343"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD2" evidence="1">
        <location>
            <begin position="557"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal" evidence="1">
        <location>
            <begin position="770"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="607"/>
            <end position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="867" mass="96570" checksum="308B9816E0DFD15C" modified="2003-06-01" version="1">MNPEQFTESLQQALQQAQQIAQTRRHQEIGVPHLFKFLTQPGELVRQIFSEAGADLDQLQTELDRELDDIAVVSGGNVQYGGSMSSSLATLMQAADAKRKALGDDYLATDTLALALMDQTGDQLTKYLNQQGITAGQVKNAVDRIRGGQRVTSRNQEDQYQALEKYGVDLVKQARQGNQDPVIGRDEEILDVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVRGDVPENLKDKTLFSLDMGSLIAGAKYRGEFEERLKAVLKEIKKSDGQIIMFIDEIHNIVGAGKTEGSMDAGNLLKPMLARGELHLIGATTLDEYRQYMEKDKALERRFQKVLVAEPSVEDTISILRGLKERFEIHHGVRIHDNALVAAAKLSDRYITDRYLPDKALDLVDEASAEIRVEMNSNPTELDQVNRQLMRLEVEEAALKKETDDASVKRLADVQKELASAKEKQRTLSERWDSEKKSLQALSDKKSALDKAKHDLENAENNYDLEQAAKLQHGTIPKLEQELKAMEANDHHEDWLVEESVTPDQIANVVSRMTGIPVAKLVAGEREKLLHLADHLHERVVGQDAAVDAVSDAVLRSRAGLQDPNRPLGSFMFLGPTGVGKTELAKALAENLFDADDHMVRIDMSEYMEKESVSRLVGAAPGYVGYEEGGQLTEAVRRNPYSIVLFDEIEKAHPDVFNILLQVLDDGRLTDGQGRTVDFKNTILIMTSNLGSELLLAGVDDQGHLSADTHQQVMQLVQSRFKPEFLNRIDDIIMFTPLQLGAIEEIVVKLIDRLSARLQDREITLKISDEAKKWIAKQGYEPAYGARPLRRFITNHVETPLAKEIIAGRVAPKSTVAINLMDDHLVFENQSTQPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-29" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WI3</accession>
    <accession>F9UP20</accession>
    <name>TRPD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name type="ordered locus">lp_1654</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WI3"/>
    <dbReference type="SMR" id="Q88WI3"/>
    <dbReference type="STRING" id="220668.lp_1654"/>
    <dbReference type="EnsemblBacteria" id="CCC78959">
        <property type="protein sequence ID" value="CCC78959"/>
        <property type="gene ID" value="lp_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1654"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1395"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_9"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="PhylomeDB" id="Q88WI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1422-MON"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154453" description="Anthranilate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="339" mass="35696" checksum="32DBE681F6BD3BAA" modified="2003-06-01" version="1">MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATAMRSQALPFKVKRPTLEIVGTGGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAADVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRFVAPARQQIKIPTIFNILGPLANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHGQQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIAKPQLDLAAAFELAQQTIDQGAAAAKLAQLIQSSQAVMAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WL7</accession>
    <accession>F9UNY6</accession>
    <name>KGUA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmk</name>
        <name type="synonym">gmk1</name>
        <name type="ordered locus">lp_1612</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889439.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WL7"/>
    <dbReference type="SMR" id="Q88WL7"/>
    <dbReference type="STRING" id="220668.lp_1612"/>
    <dbReference type="EnsemblBacteria" id="CCC78925">
        <property type="protein sequence ID" value="CCC78925"/>
        <property type="gene ID" value="lp_1612"/>
    </dbReference>
    <dbReference type="GeneID" id="57025195"/>
    <dbReference type="GeneID" id="66449495"/>
    <dbReference type="KEGG" id="lpl:lp_1612"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1360"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_0_9"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="PhylomeDB" id="Q88WL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1387-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000170552" description="Guanylate kinase">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <sequence length="206" mass="23461" checksum="1F05F4B7E4088584" modified="2003-06-20" version="1">MAKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKEEFEDEIKSGGMLEYAKYVDNYYGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVFIFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMMRNYDYAVINDEVPLAAERIKAIIRSERFSVKRVMPEYEEMLGDAES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW4</accession>
    <accession>F9UMM7</accession>
    <name>IF1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name type="ordered locus">lp_1059</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888980.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW4"/>
    <dbReference type="SMR" id="Q88XW4"/>
    <dbReference type="STRING" id="220668.lp_1059"/>
    <dbReference type="EnsemblBacteria" id="CCC78466">
        <property type="protein sequence ID" value="CCC78466"/>
        <property type="gene ID" value="lp_1059"/>
    </dbReference>
    <dbReference type="GeneID" id="49393339"/>
    <dbReference type="GeneID" id="57024713"/>
    <dbReference type="GeneID" id="66448969"/>
    <dbReference type="KEGG" id="lpl:lp_1059"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.893"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_9"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="PhylomeDB" id="Q88XW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-909-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000095806" description="Translation initiation factor IF-1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8236" checksum="DC78F5BFCBF9349A" modified="2007-01-23" version="3">MAKEDVIEIQGTIKETLPNAMFKVELENGAEILAHVSGKIRMHYIRILPGDKVTVEMSPYDLTKGRITYRFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YI6</accession>
    <accession>F9ULZ8</accession>
    <name>LUXS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="1">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">luxS</name>
        <name type="ordered locus">lp_0774</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888751.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YI6"/>
    <dbReference type="SMR" id="Q88YI6"/>
    <dbReference type="STRING" id="220668.lp_0774"/>
    <dbReference type="EnsemblBacteria" id="CCC78237">
        <property type="protein sequence ID" value="CCC78237"/>
        <property type="gene ID" value="lp_0774"/>
    </dbReference>
    <dbReference type="GeneID" id="57024478"/>
    <dbReference type="KEGG" id="lpl:lp_0774"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.654"/>
    <dbReference type="eggNOG" id="COG1854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107531_2_1_9"/>
    <dbReference type="OMA" id="QWSRDIL"/>
    <dbReference type="PhylomeDB" id="Q88YI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-672-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0071">Autoinducer synthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0673">Quorum sensing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000172233" description="S-ribosylhomocysteine lyase">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <sequence length="158" mass="17428" checksum="3EC768414712AE05" modified="2003-06-06" version="1">MAKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHMLAGLLRDRMDGVIDCSPFGCRTGFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTTIDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY2</accession>
    <name>F9UKY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdaC</name>
        <name evidence="8" type="ordered locus">lp_0502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0502"/>
    <dbReference type="EnsemblBacteria" id="CCC77997">
        <property type="protein sequence ID" value="CCC77997"/>
        <property type="gene ID" value="lp_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0502"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.414"/>
    <dbReference type="eggNOG" id="COG0814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052043_1_1_9"/>
    <dbReference type="OMA" id="KDFTWCL"/>
    <dbReference type="PhylomeDB" id="F9UKY2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-418-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="426" mass="46886" checksum="67C9506C72359025" modified="2011-10-19" version="1">MTNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRGLSRFVLSAKNDGDDITDVVEQHFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITDQMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAFPFIIVIVLFSFYLIPHWNGAILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKKISTILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSPVIAFIAIAKSFLGHYLGTSEGLRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWVNPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGKHSNVFVVVIGLIAVSGILFNIIKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL34</accession>
    <name>F9UL34_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="GeneID" id="66448620"/>
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    <dbReference type="eggNOG" id="COG0474">
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HAD-like_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="884" mass="95312" checksum="635B6CA8DAEF47F6" modified="2011-10-19" version="1">MSTKPKYQQALSAVYEELGTDEHGLQQSAATQRLEQYGPNALNQQKATSLLQKFIAQFKDFMIIVLLVAALIAAFTGEAVDAVIILLVVVLNAIFGVFQESKAEEAINALKEMSAPDATVLRDGQLQTVKSDALVPGDVVSLEAGDIVPADLRLIESASLKVEESALTGESVPVEKQAEMIADGELPIGDRLNMAYMNSNVTYGRATGIVVATGMQTEVGRIAGMIEAADETTTPLQANLTQLGKSLTILILVIAAVVFGIGMLRGQESLINMLLTAISLAVAAIPEGLPAIVTITLALGTQRMAKRHALVRKLPAVETLGSTDIIASDKTGTLTQNKMTVEKLVVNQELVDARATELPLDSHLAQVMILSNDTKIMPDGLAGDPTETALIQYNLDQGYPVDQLLTDRPRVTEVPFDSERKLMSTVHPLEDGRFLVAVKGAPDELLKRVTQIESNGDVQPLTKTSRDQILTVNHELATQALRVLAFAYKVITTVPTTVNTETLENDLVFAGMVGMIDPERPEVEQAVAEAKSAGIRPLMITGDHRDTAEAIAVRLGIINAGEDDAVITGAELDAMSDAEFGKKVGDYSVYARVAPEHKVRIVNAWQKRGKVVAMTGDGVNDAPALKAADIGIGMGITGTEVSKGASDMVLADDNFATIVVAVEEGRKVFANIQKAIQYLLSANLGEVLTLFVMTMLGWQILAPVHILWINLVTDTLPAIALGVEPTEKNIMQHKPRGRNSNFFSGGVFSSIIYQGLLEGGITLLVYWLALTYPVHATASLAHADALTMAFATLGLIQLFHAFNSKSIHESLFTVGLFRNKFFNWAILIAFVMLAMTIVVPGLNGLFHVSHLDAYQWGIVALASLSMVVIVEIVKFFQRRHMRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL88</accession>
    <name>F9UL88_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prophage P1 protein 1, integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101076.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888617.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0624"/>
    <dbReference type="EnsemblBacteria" id="CCC78103">
        <property type="protein sequence ID" value="CCC78103"/>
        <property type="gene ID" value="lp_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0624"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.523"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_6_9"/>
    <dbReference type="OMA" id="RHYFATM"/>
    <dbReference type="PhylomeDB" id="F9UL88"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-534-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="181"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="400" mass="45997" checksum="449A5651932D485F" modified="2011-10-19" version="1">MPRQWKPLKRHPGIYEYETKRGKKYGIRRSYTDINHKYRTWSKSGFITWRDADIELKKFEVTLGTGQITASISDTITLQAYFDKVLKRNIDLKLWRPATITQKKNYWNNQLKPVFGNQKINEITRQSYQNFIDQMIKDGYAKNTIITTNSVMQILMNDAVRNDVIVKNKLSGISIDGGKSPSSKTITEKQYNQLMTIAPSVLSKYQYCMLALLTLGERREELMGLQFSSFKFSQWNDEEVCAIQFKKGRTNAEPEGGDLKNNSSYRTIYVRGEMLNICHYAITYSQNIYSKTHRNINDESFLFVNEKTGMPMGVQQANKVLNKVGEATGIHITPHIFRHYFATMALTNGQVATDVMHWLGHSSLQMTQSYTRENVRGALNVFNGMAPTLLGDSDDEHQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL97</accession>
    <name>F9UL97_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 11, phage transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-10" db="PDB data bank">
            <title>The crystal structure of the prophage Lp1 protein 11.</title>
            <authorList>
                <person name="Zhang R."/>
                <person name="Zhou M."/>
                <person name="Keigher L."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888626.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3B7H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=1-78"/>
    </dbReference>
    <dbReference type="PDBsum" id="3B7H"/>
    <dbReference type="SMR" id="F9UL97"/>
    <dbReference type="STRING" id="220668.lp_0634"/>
    <dbReference type="EnsemblBacteria" id="CCC78112">
        <property type="protein sequence ID" value="CCC78112"/>
        <property type="gene ID" value="lp_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="66450184"/>
    <dbReference type="KEGG" id="lpl:lp_0634"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_50_1_9"/>
    <dbReference type="OMA" id="MKLCNER"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-545-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3B7H"/>
        </source>
    </evidence>
    <sequence length="78" mass="8788" checksum="A97AED3CFA54814C" modified="2011-10-19" version="1">MKTDGEFVSEHLMELITQQNLTINRVATLAGLNQSTVNAMFEGRSKRPTITTIRKVCGTLGISVHDFFDFPPYNEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA6</accession>
    <name>F9ULA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3549"/>
    <dbReference type="DNASU" id="1061966"/>
    <dbReference type="EnsemblBacteria" id="CCC80513">
        <property type="protein sequence ID" value="CCC80513"/>
        <property type="gene ID" value="lp_3549"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3549"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2960"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_9"/>
    <dbReference type="OMA" id="AIGAKHQ"/>
    <dbReference type="PhylomeDB" id="F9ULA6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3001-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="28492" checksum="0FCA3D02516EC675" modified="2011-10-19" version="1">MEVMQRQKYILDQLRQQGTIKITDISKEISVSRETVRKDIYTLDKQGLVQAIRGGATTPQSVNETKYGKRQHEAVAEKKEIATNALRLIHDGESIFLDYGTTAFQVAEKIKRSQLTNLTVITNSTFVLNSLQFVKDIQFVLLGGTMRTSEGSLSGPITLDNIDNLYADIGFFGCGGVDLQAGITNHYIEEVEVSKKMMSHCRMKVILADHTKFEKNALYKTTDISNVDAIITDEQLDSRLAKQIRLADISLISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB3</accession>
    <name>F9ULB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arabinose (Promiscuous) transporter, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">araP</name>
        <name evidence="10" type="ordered locus">lp_3557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102219.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891034.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3557"/>
    <dbReference type="EnsemblBacteria" id="CCC80520">
        <property type="protein sequence ID" value="CCC80520"/>
        <property type="gene ID" value="lp_3557"/>
    </dbReference>
    <dbReference type="GeneID" id="57026756"/>
    <dbReference type="KEGG" id="lpl:lp_3557"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2967"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_9"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="PhylomeDB" id="F9ULB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3008-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="12"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="50672" checksum="1D6EC87FA6F0632D" modified="2011-10-19" version="1">MNKQKKVSSKFIFFFGSFGGILFGYDIGVMTGALPFLKTDWALTNATLVGWVTSAVMFGAIFGAAIAGQLADRLGRRRMILMSSLIFAIGSILCGFSPNNGTYYLIGMRIFLGLAVGAASALVPAYMSEMAPARLRGSLSGINQTMIVSGMLISYIVDYILKDLPENMSWRLMLGLAAVPAIILFLGVLKLPESPRFLIKANRLDEARQVLSFVRKPDEVDSEVKAIQSTAQTEANNLEKTSWATLFNGKYRYLVMAGVGVAAFQQFQGANAIFYYIPLIVEKATGSAASSALMWPIVQGILLVLGSLLYIWIAEKFNRRTLLMLGGSVMALSFLLPAVINSLVPNASPMMIVVFLSIYVAFYSFTWAPLTWVLVGEVFPLAVRGRASGLASSFNWIGSWAVGLLFPIMTASMSQEAVFAVFGVICVLGVLFVRFCVPETRGHSLEEIEAAGTNHHKQVPVQQASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG4</accession>
    <name>F9ULG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase-like (Promiscuous)</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
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                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        </source>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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    <accession>F9ULP0</accession>
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        <submittedName>
            <fullName evidence="2">Prophage P1 protein 28</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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</entry>
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    <accession>F9ULP3</accession>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_0654"/>
    <dbReference type="EnsemblBacteria" id="CCC78132">
        <property type="protein sequence ID" value="CCC78132"/>
        <property type="gene ID" value="lp_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0654"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.547"/>
    <dbReference type="HOGENOM" id="CLU_1822907_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-565-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012865">
        <property type="entry name" value="DUF1642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07852">
        <property type="entry name" value="DUF1642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <dbReference type="EMBL" id="CCC78132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16722" checksum="1F844ABE2DE9C872" modified="2011-10-19" version="1">MIKVYLKQPVYVERIDELGTGLIDKYEIYSLSGGMWHPHDEVGHSMLCSGHLEWGDWIATGANGSHWIIPNALYEQQYGELPVIPKAVADYMKDCKNPTNSAFHSTLYEAFDELFAASQDVEHWIEHNSDVFARAWLDGYQVEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS8</accession>
    <name>F9ULS8_LACPL</name>
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        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0691</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
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    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888681.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0691"/>
    <dbReference type="EnsemblBacteria" id="CCC78167">
        <property type="protein sequence ID" value="CCC78167"/>
        <property type="gene ID" value="lp_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0691"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.580"/>
    <dbReference type="eggNOG" id="COG1611">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_2_9"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="PhylomeDB" id="F9ULS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-601-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="191" mass="21151" checksum="0250246A40C513CC" modified="2011-10-19" version="1">MAIHNICVFCGSNSGLDPAFSEKTVALGQYLAANDYQLVYGGGDHGLMGKVAKATMDAGGRVIGIIPHFLVARELAFKDVTTFIETRTMTERKEKMLHLADAFIVLPGGFGTFEEFLQMLSWSQMDIHQKPIALYNIDGFYDDLVAMLQKTADLGFAPEANLDLFINGHDLDEIFAGFHDFKHVLPPKYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM21</accession>
    <name>F9UM21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101160.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UM21"/>
    <dbReference type="STRING" id="220668.lp_0800"/>
    <dbReference type="EnsemblBacteria" id="CCC78260">
        <property type="protein sequence ID" value="CCC78260"/>
        <property type="gene ID" value="lp_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0800"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.677"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000868_0_0_9"/>
    <dbReference type="OMA" id="GQATHPI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-696-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07523">
        <property type="entry name" value="Big_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394383" evidence="5">
        <location>
            <begin position="40"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="7">
        <location>
            <begin position="1934"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="2097"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2010"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2019"/>
            <end position="2042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="2139" mass="226353" checksum="71C8B7CDB8EC5838" modified="2011-10-19" version="1">MNRFITSKQHYKMYKKGRFWVFAGITVATFTLNPLISRADTETTTAATAATTTAGASSSSNSQVLRTTTTSTTGATTQSSATAINAATTNTSAQKKQAVSGTTTDSKAEQPVTAVGENENATSNLSTSDSASASSQAKTGSGNSLDQTSNSSVSVASSSQKVTTQNSDYQNDQGTGSESGIQSNVTDTVVADESLQTNRSSVASPSTSTMASIGDSDSKDSNETEKVVDSETSPIVVTATTNTITTTNDKVQLNRALLARAAIPAIVQSGTLGTSQWTMNSDGVVTIGAGDWSNVDDVSALFYTLGSTVTGVVIDGKVNAGEDLSYLFFKSPNLATITGFQNIDTSKVTDFSYMFCGTSVADFSSISHWDVSDSENFDSMFTSNSKVQSIDLSHWELSQAQSIKMRRMFAADTALISMDLSAWNMSMVTNINGMFAGNDLNTMALKSVDLHGWNLKNVTDMGTMFNFDNSLTSVNMSGWQTSSNLSSVDSMFRGTSSLASLDLSSIDLQGVTRKYMLLSQNKLYDPISSSLSTLTLGTMSVLTDTGLPDIPTGTGYTGKWVNQADATQTYTSSELMALYNGVDSPADTITWVWETSPSYADFTSKNVTGLIAGPKTTWRVADSVATLKDVNGTDIYATADTVVKVISVNGDTAVTTVDTQTAGTYQVDLQYTDAYGKVWQQTSTVAVAVNQGKLVGKPLTIKMGAKPTYTINDLIDTDNSRNAAGDKLSADELATATVTGLDTSKAGAQTVTLAYTDDATGMVHTTTTTVTMVATKADLTMRNSTIIKGPKNSSWDYRQYVTSVTDFDGNPVSLDGLNIVVDQQPDLTQIGSQTVTLTYTDALGNVISVPTQVTVVASRAQVTTKAPLTIWPSEVAQLKVADLVTITAANGNPVDTSTDLTDVTMSSIDTSKGGAQTVTITYTDEAGNLVTAYAKVTVDQSDLKTKLTNPIAGPKAKWDYLAGLEWVKDANGKLLDNLATADIKVVTEPDLSVAMVGHDQTVTLSYMDELGKEHLVTAVVNTVASKAKITAVSDQIIIPDEAKKLTATDLVSELIDAAGNKATNFDDVTMSGFDAKAIGPQTVTLTYSDAYGNQTTDSTTVTVDFATITGQATHPIAGPTATWDYRDSVTQVIDANGKIIDVGDADITATTPDLTPAKVGKPQTVTLTYTDSLGKVHTTDVIVTTTLSKAKITAVADQIIWPDQAKQLTATDLVDRLYDAEGHLITNHDNVKMSVLDSKLAGQQRLTLTYTDVAGNQSVAYANVTVDQAKLVTKPSTVIAGPTATWSYEAGISQLTNAAGQLITVQPGTIKVLNRPDLNVDSVGQQQLITLIYTDELGKSQSVTAMVTAEASQAMLTAKAAVIVQPDASAKLTANDLVTSLTDASGQQVTDYQIVRMSKLDATWPGVQPVSLTYTDAAGNEVSTVVKVTVDQAKIDSQNRTQIWGPSMTWDYRQQLATVTDSQGHQFNPDQAKITVITGPQLTAKMIDKPQTVTLMYTDDLQQTHTVSATLTLTASQAALVPRPAQIVWAKDAGLLTPANFSQTITGADGTQVSSLTNVKMSAVDASQPGAQTVTLTYIDDYGNEVTTTAQVTVDQAALTTQTARPVAGPTAKWDYQTNFKTVTNAAGEVINVGDANIKVLTGPDLSTAMVGRPQVVTFSYTDELGLTQTATAKVTTVASRAHMTTSADQVTWPATVGKLTVADLVTGLTDAWGQTSQNYQNVTMTTINAQQAGKQQVTLTYTDEVGNVKTATTTVTVDQAALTTQPQTVIAGPTAKWDYHQGIGTITDGMGQPIAVNNAAITVVAMPDLTVAHIGQPQTVQLVYTDSLGQQQTALVQVTTVATQAKISTRPVTVIAGPKTTWSLNDSVDWSTSLAADGTLLTAAQRQRVTVDGTLNLRRAGNYPLTLSYMDRAGNLITVTTSIDVLASQAQLQVRDSQLTVGNTWAAQDNFERATDAQGQALTLADIAVDGTVNTQHAGRYTLTYHYTDVAGNQLTKTAVVTVVLPEDDHINTADPDNNDHAGITNPSETPKPSEQPNDSDGHTVDWGVDDRITTKQQPAAATRAQTKVKMTAEPALPANNERTSATKAVTRVTDTTADTLPQTGERDRSAQQGAVVLGLTGLLGLMGLGRRRHTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM88</accession>
    <name>F9UM88_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system, EIIA component</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pts11A</name>
        <name evidence="5" type="ordered locus">lp_0884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888841.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0884"/>
    <dbReference type="EnsemblBacteria" id="CCC78327">
        <property type="protein sequence ID" value="CCC78327"/>
        <property type="gene ID" value="lp_0884"/>
    </dbReference>
    <dbReference type="GeneID" id="57024568"/>
    <dbReference type="GeneID" id="66448831"/>
    <dbReference type="KEGG" id="lpl:lp_0884"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.748"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_5_4_9"/>
    <dbReference type="OMA" id="INCMVEN"/>
    <dbReference type="PhylomeDB" id="F9UM88"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-763-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="4">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="17356" checksum="E4092EA0339D846B" modified="2011-10-19" version="1">MFGIKRKKVDVFEVVTPIEGICIPITAVMDEVFAKKMMGDGFAIRPSEDTNQVVAPISGKIVALPESKHAIGIMDETRGVSVLVHIGLDTVGLNGRGFTAHVKLNQEVKAGTLLVTLDRQTMATAGLDMTTIVVFTEGYTGEVPLGSKLHQQLAAGTPVLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG2</accession>
    <name>F9UMG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, YibE/F family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101233.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0968"/>
    <dbReference type="EnsemblBacteria" id="CCC78401">
        <property type="protein sequence ID" value="CCC78401"/>
        <property type="gene ID" value="lp_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0968"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.824"/>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028166_1_1_9"/>
    <dbReference type="OMA" id="YESMQYV"/>
    <dbReference type="PhylomeDB" id="F9UMG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-837-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="416" mass="45951" checksum="F365284DB93CCE04" modified="2011-10-19" version="1">MAESFTRSSNGLDYRRNLDSVKDCQNRSLYWGMGGKLVTIEVKKGENVKQRIKQRWGLWLTLLVIVLGLIGVGLTRVNAGLYQQTVAQVTHVQTKSRSTTTDEFENKDATVTQLVTVRVLNKAHRGRTYQIKNTYTRSGAMDQPYHVRNQVFLRIPSDHSSAVTIQGLKRDTALAFVAWLALALLLLIMRFSGLMAFLSVALNAVLFYAAIQIDLATNGDHIYLLFGVLAVIFAVLTLLLVLGFSRQMLVTLGATVVGTGLAVIISLIVFAVTHERGVTYESMQYVTQVPRPLFLVETVLGSLGAVMDESTDIVASLFQLKTERPDIAPRQVFKSGIQIGRSIMGPLINVLFLIFMADTFAMTLLYFRNGNSWGYTFTMNMSLGMVQSLISGIGIVLAIPVASWLASRLMPKAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI1</accession>
    <name>F9UMI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal-dependent regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78420">
        <property type="protein sequence ID" value="CCC78420"/>
        <property type="gene ID" value="lp_0996"/>
    </dbReference>
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    <dbReference type="GeneID" id="66448914"/>
    <dbReference type="KEGG" id="lpl:lp_0996"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.843"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_2_9"/>
    <dbReference type="OMA" id="PKYDPHG"/>
    <dbReference type="PhylomeDB" id="F9UMI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-856-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
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        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="23935" checksum="4BD8D54695449E22" modified="2011-10-19" version="1">MTPMKEDYLKIIFELGGTKKKVSNKQIALSLDIAAGSVTEMVGKLVQEGLAKHTPYAGISLTKKGIRYAETLVRKHRIWEDFLVDKLDYDLPDVHTEAEVLEHVTSERLVDSLEAFLGNPTHCPHGGAIPDKDGHYQEDSHVSLADTQDGTTVTIERFIDNHDLLVYLHDTPLKIGQQVTVLKHDPFEGPVTVSIQKTGEEIPVSYKAAHNVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ2</accession>
    <name>F9UMJ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dacB</name>
        <name evidence="4" type="ordered locus">lp_1010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1010"/>
    <dbReference type="EnsemblBacteria" id="CCC78431">
        <property type="protein sequence ID" value="CCC78431"/>
        <property type="gene ID" value="lp_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1010"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.856"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054193_3_1_9"/>
    <dbReference type="OMA" id="DYESWHF"/>
    <dbReference type="PhylomeDB" id="F9UMJ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-867-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389001" evidence="2">
        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="88"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="28242" checksum="3A53BB504EAFA54B" modified="2011-10-19" version="1">MLKRNLLRGLALVSLAGVLAGCGASQSTSKATSSSTSAKSTKTQTKRQRLISALPKGVKSTDSDLVVVNKWHKRAEMTFNKSSVDGIEVRSSIVKPLEAFLAGAKKAGYPATIVSGYRSVAYQKEVWDQSIQTYENQGKSAKEALKLTKEYVAVPSGSEHETGLAADIMNTHWYSTHGNQLLSSSDKNKGQQWLINHAADYGFVLRFTKDGKQSTGIDYESWHFRYVGKASAEFMTKHNLTLEQYVSLLQAREKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS9</accession>
    <name>F9UMS9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889032.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1121"/>
    <dbReference type="EnsemblBacteria" id="CCC78518">
        <property type="protein sequence ID" value="CCC78518"/>
        <property type="gene ID" value="lp_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="57024766"/>
    <dbReference type="KEGG" id="lpl:lp_1121"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.948"/>
    <dbReference type="eggNOG" id="COG4684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088550_0_0_9"/>
    <dbReference type="OMA" id="FVAYTQP"/>
    <dbReference type="PhylomeDB" id="F9UMS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-961-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="193" mass="20676" checksum="FBE15C52BE46AB66" modified="2011-10-19" version="1">MQRRSNAYHISVLAVLMAIVIIQNIVPFFGYIPLPGLSITTIHVTVILAAVVLGPRDGAIIGGAWGIIAWIRAFVAPTSPLAPIVFTNPLISVIPRILVGLIAGWVFIWFQKRHQKVLGMTLAGVAGALTNTILVLGLIGLLYSHQAAGFYQVNLSKLMPYLLTIVASNGIPEAILAGILTPLIGTPLLRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT2</accession>
    <name>F9UMT2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome D ubiquinol oxidase, subunit I</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ordered locus">lp_1125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641324.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889035.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1125"/>
    <dbReference type="EnsemblBacteria" id="CCC78521">
        <property type="protein sequence ID" value="CCC78521"/>
        <property type="gene ID" value="lp_1125"/>
    </dbReference>
    <dbReference type="GeneID" id="57024768"/>
    <dbReference type="GeneID" id="66449021"/>
    <dbReference type="KEGG" id="lpl:lp_1125"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.951"/>
    <dbReference type="eggNOG" id="COG1271">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_9"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="PhylomeDB" id="F9UMT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-964-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="479" mass="53711" checksum="AC4881EFD438184D" modified="2011-10-19" version="1">MNLGLSILSLARFQFAMTTVFHFFFVPLSIGLALVVAIMETVYVVKKDIMYKHMAQFWGRIFLLSFAVGVVTGIIQEFQFGMNWSDYSRFMGDIFGAPLAIEALVAFFMESTFIGLWMFGWDRFNAKLHCAFIWLTSIGTMISAMWILAANSFMQNPVGFMINTKTGRAQMTSFAAVVKNEQLWYELPHVLFGAFVTGSFVVAGMAAFALLKKKNVTFFRKSIKVSLIVGLVASIGVIGMGDLQTRYIIKEQPMKFAATEGLYKDSGSPASWAVIEGMDTKNHKANWSIEIPYVLDILSYHKLSGNVKGQNTLNKELHAKYDKKFGKDMNYYVPTKTLFWSFRVMTVAGGLFALIAIIGLYFNRAKSTLIERQRWFLWVLGICTFLPFAANTAGWLITELGRYPWVVYGLLTIADAVSPNVSVASLLISNIVYFCLFSGLGIVMIVLSRRALHQGPDDLLQASDDAPYDPYGKEAFSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN12</accession>
    <name>F9UN12_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2 (GT2)</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3A</name>
        <name evidence="2" type="ordered locus">lp_1215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889115.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1215"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063074"/>
    <dbReference type="EnsemblBacteria" id="CCC78601">
        <property type="protein sequence ID" value="CCC78601"/>
        <property type="gene ID" value="lp_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1215"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1031"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="NTLCFEG"/>
    <dbReference type="PhylomeDB" id="F9UN12"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1043-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
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    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="303" mass="35135" checksum="261242C2851C4F0C" modified="2011-10-19" version="1">MTKIACVIVTYNRKQLLEEALNSVLIQTESPEYVFVIDNASTDGTEKYINDKFNFDNRQWHYVRCSQNLGGSAGFAQGMRLALQTDCSWISISDDDAIFEPGYFAALRKGIKQYPEQSVFSGSVLLPDGKHDMMHREVITNSATLTVRCVTDETYKHDFSYDIFSFVGILLSRQVIEAIGLPEQDYFIRFDDFEYAVRALKFGRFMNLSAAKVLHKTTYTRSAIAPWKEYYVMRNRIALLIKHRGNNHTVRWYCRRFLLRKLLAILLFSNRRRQARSLVNAYVKGYQDGWHARLGRQLAFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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    <dbReference type="GeneID" id="66449136"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="13683" checksum="DABB9A68BFF9A7C6" modified="2011-10-19" version="1">MDKQKTTKAQEMHAVEMMIGYILRIGVIVSAIVIIIGMLLMLIQGNGGYANGMEPHTVADILAGIVALKPYAVIMLGLFLLILTPTLRVAVSIYAFAVEKDHLYVWITTIVLIILIVASVIGYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN67</accession>
    <name>F9UN67_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane sulfatase, alkaline phosphatase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_1283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LTA synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCC78656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1283"/>
    <dbReference type="EnsemblBacteria" id="CCC78656">
        <property type="protein sequence ID" value="CCC78656"/>
        <property type="gene ID" value="lp_1283"/>
    </dbReference>
    <dbReference type="GeneID" id="57024897"/>
    <dbReference type="KEGG" id="lpl:lp_1283"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1088"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021310_0_0_9"/>
    <dbReference type="OMA" id="VSNHRPF"/>
    <dbReference type="PhylomeDB" id="F9UN67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1098-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="253"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="701" mass="79043" checksum="23306F209E6D9307" modified="2011-10-19" version="1">MPKFIKNTVGKVNTTLGFYLLTVVLFWLKTYIAYKSEFTLGVKGPVQEFILFLNPFPTAIVLLGIALYFRGRLKYWIMMIIDALQTTWLFANILYYREFSDFMSAGVIKSSGAASNNLGKSLGQIIHGTDFLVYADVVLLILLLAFKVIRIDPRPFKIRYAATLTMIGVALFAVDLGMSEHDRSDLLTRTFDNNYIVKYLGLNTYAGYSFYQTEKESATRAQASSSDMKSVLAYLKKNQAGENVKYFGKAKGKNVFVIHLESFQQFLIDYKVDGKEVTPNLNKFYHDKSTLSFDNFYHQVAQGKTSDAEMMMENSLFGLPTGSAMTQYGTSNTFQAAPAILSQKGYTTAAFHGDVASFWNRDNAYKSWGYNYFFYSSYYKEKSDYNIGYGLKDKIFFKDSVKYLEQLPQPFYAKLITLTNHYPYELDKKNQSIDKTTTGDSTVDGYVQTAHYLDQAFAEFISYLKKAGLYKNSMIVLYGDHYGISNNHKAAIAQLLGKKSVTSFDLAQFQKVPFMIHSEGIKGGINHTYGGEIDALPTIFDLLGIKNKGYIQFGTDLLSKQHNQTVAFRNGDFVSPTYTKISGTVYDSKTGKKLTDMTTKQKDTVKQMQNHVTTELSLSDRVIQGDLLRFYTPKGFKKVNKSDYSYKLTKTLKSLKEIQAEKKTSVLSKHKGKSTESLYKTDAPELSSSSDSSSSSSSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN76</accession>
    <name>F9UN76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-methylmethionine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_1297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101342.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889179.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1297"/>
    <dbReference type="EnsemblBacteria" id="CCC78665">
        <property type="protein sequence ID" value="CCC78665"/>
        <property type="gene ID" value="lp_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1297"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1097"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_9_2_9"/>
    <dbReference type="OMA" id="WEGGVHL"/>
    <dbReference type="PhylomeDB" id="F9UN76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1123-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="15"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="460" mass="50430" checksum="7240F8B7818B0885" modified="2011-10-19" version="1">MSKQTHLSRQMESRHVLMISLGGVIGTGLFLSSGYTIHQAGPIGTLLAYTIGAILVYLVMLCLGELSVAMPYTGAFHVYAKKYIGPGTGFTVAILYWLTWTIALGSEFTAAGLIMQTWFPHIATWIWSLVFMVVIFTVNALSVRWFAETEFWFASIKVIAIIAFIVLGGLAMVGILPLHGHTSAPFLSNYTRNGWFPNGFGGVFTTMLTVNFAFSGTELIGITAGETKDPAHTIPTAIKTTLWRLIIFFIGSMFVMAALIPYKQAGVTQSPFVLVFKAIGIPYAADLMNFVVLTAIMSAANSGLYASTRMLWSLANEGTIPKVFKRTTKRDVPLVALITSMLGGILALLSSVYAAGSVYLVLVSISGLAVVIVWMAIALSEINFRKAYLKSGQSLDQLTFKTPGYPVVPWLAFILSGLSCILIWFDPNQRIALYYTIPFVAICYLGYYLNQRYRRTHAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA7</accession>
    <name>F9UNA7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrsA1</name>
        <name evidence="4" type="synonym">msrA</name>
        <name evidence="6" type="ordered locus">lp_1339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644244.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1339"/>
    <dbReference type="EnsemblBacteria" id="CCC78696">
        <property type="protein sequence ID" value="CCC78696"/>
        <property type="gene ID" value="lp_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1339"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1128"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_4_1_9"/>
    <dbReference type="OMA" id="FWPAENF"/>
    <dbReference type="PhylomeDB" id="F9UNA7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1154-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015046">
        <property type="entry name" value="LciA_Immunity-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08951">
        <property type="entry name" value="EntA_Immun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="98"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="31239" checksum="48A3C198C318BD01" modified="2011-10-19" version="1">MKTKPEALMRDLYNLIINPATRDWERHLLVQAKNNRQQLSPTGQLKQLEADLRPLAMRNNLTPDVMDFYLAITGNAPMPTKNNVSAYPTLSSPYEERAVFAGGCFWCMVEPFDQRPGINNVISGYTGGSWAQPTYEQVSGQYTGHVEAVEIRYDSRKISYQNLVDIYWQLIDPTDRFGQINDRGSQYRPVIFYANQHQLTIAQASKQALVDSQRYQKPIVVAIEPLQQFWPAENYHQDFYRKQPRRYRQLKKAHDHYLNWLKFKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB1</accession>
    <name>F9UNB1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">asd1</name>
        <name evidence="12" type="synonym">asd</name>
        <name evidence="14" type="ordered locus">lp_1346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101363.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889214.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1346"/>
    <dbReference type="EnsemblBacteria" id="CCC78700">
        <property type="protein sequence ID" value="CCC78700"/>
        <property type="gene ID" value="lp_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1346"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1132"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_9"/>
    <dbReference type="OMA" id="MFDVPDE"/>
    <dbReference type="PhylomeDB" id="F9UNB1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1158-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="360" mass="39120" checksum="E8B3C18CD28756D2" modified="2011-10-19" version="1">MSKSYVVAILGATGAVGTRMVDQLAESDIQVSKLKLLASARSVGKKMGFRGQSLTVQAATPDSFNGVDIVLASAGGQVSARLLPEAVKRGAVCIDNTSYFRMNDHVPLIVPEVNVDQIQNHHGIIANPNCSTIEMVVALNPVRVKYGLKQIIVSTYQSAGGAGQAGIKELYREAKAYLNNEPVKSEILPVKGGKRHYPIAFNLLPQIDVFENNDYTHEEQKMIHETKKIMCGDKNSTELKITATCVRVPIPIAHGETVYFTTEMTPSSDDIRRTLTKAPGVVVQDDPQHQVYPQPVNVIGSDATFVGRVRSDMENQRAYHMWVVADNLIKGAAGNAVQIAEELINQGAVHESKASAVLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC3</accession>
    <name>F9UNC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643152.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78712">
        <property type="protein sequence ID" value="CCC78712"/>
        <property type="gene ID" value="lp_1358"/>
    </dbReference>
    <dbReference type="GeneID" id="57024961"/>
    <dbReference type="KEGG" id="lpl:lp_1358"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1143"/>
    <dbReference type="eggNOG" id="ENOG50309ZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012305_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1170-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="13761" checksum="0F7522A1F1F2863C" modified="2011-10-19" version="1">MLVVGIILVIGIIGTLVLRFQFHFRLAMGTITETAFACSLLNIGVFLLFILLGQLTGPILLSEWAYLPIYRLLQGGLIPVIGIGLAILGMVREKGLMNWWLLHFNVLFLIFDVLLVWQGSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="8" type="ordered locus">lp_1372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889235.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1372"/>
    <dbReference type="EnsemblBacteria" id="CCC78721">
        <property type="protein sequence ID" value="CCC78721"/>
        <property type="gene ID" value="lp_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1372"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1152"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UND2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1181-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="52"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="20544" checksum="562250C1A5B7AA44" modified="2011-10-19" version="1">MLLYNIFELEETVANGVQWLIKIYHQYQYFWKYALFGFMAALVNVLVFWVLHSVLAEHYLFSNTIAWVLATLFSFFTNKAVVFQSKSQDFWHWCREFISFMLTRGLSYFFDTFLMFVGISLLFWAPLLVKIIDQVLVGLFNYGTSRLIFMESNQKMRMRQQIMKRLSDRNN</sequence>
</entry>
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    <accession>F9UNM3</accession>
    <name>F9UNM3_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889326.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1484"/>
    <dbReference type="DNASU" id="1062316"/>
    <dbReference type="EnsemblBacteria" id="CCC78812">
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        <property type="gene ID" value="lp_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1484"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1246"/>
    <dbReference type="eggNOG" id="COG0142">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923721_0_0_9"/>
    <dbReference type="OMA" id="HAYASQY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1273-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="299" mass="33088" checksum="3D7A2E369577C57C" modified="2011-10-19" version="1">MLLDYDVALEDDFQQFIKQIPAPVRALLDSADPVARHQRQAVYTLFGIPGRPATMTPLVEALAMVSTLDTPSFAPTPTINDLALSKAHAYASQYLLQQFIRTVSHTTMLPPANRHELLTAAQSLPLANLNRLRLNFNQRERIADFLKDTKDRPAKLTSLSGYLATSLAGLDPAICGLARAIGESVGIVLTILTDVQVTRQIADFRERLLMGNYPLPLLFGFENDPGYFYDFFHQAHKPTADQFVATQQRVLMIGVAPALTMANELVDQARLDSQQLPTDLKKRVEQALTRLAAATAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM8</accession>
    <name>F9UNM8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101435.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1489"/>
    <dbReference type="EnsemblBacteria" id="CCC78817">
        <property type="protein sequence ID" value="CCC78817"/>
        <property type="gene ID" value="lp_1489"/>
    </dbReference>
    <dbReference type="GeneID" id="66449377"/>
    <dbReference type="KEGG" id="lpl:lp_1489"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1251"/>
    <dbReference type="eggNOG" id="COG3605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141530_1_0_9"/>
    <dbReference type="OMA" id="EPAEYQY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1278-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="145" mass="16096" checksum="247EA708E7F05D69" modified="2011-10-19" version="1">MTLAENANQRNYQHLVDQLYQTSDFDFVGVALQANQAPHQITWQYVAGNRGEQFRKIILRSGIGIAGLVVRTGKPFWNNALQNATYTDVLYTPIAQAECLTSAAAIPIVTTEFRLVTGVLLAGYRSTQTVSDQTISRLSHYLATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNP1</accession>
    <name>F9UNP1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1503"/>
    <dbReference type="EnsemblBacteria" id="CCC78830">
        <property type="protein sequence ID" value="CCC78830"/>
        <property type="gene ID" value="lp_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1503"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1264"/>
    <dbReference type="eggNOG" id="ENOG50309UA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145993_0_0_9"/>
    <dbReference type="OMA" id="MNAVAHA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1291-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="142" mass="15840" checksum="642AFB0B6A4E194C" modified="2011-10-19" version="1">MRRQLLMTVDAQLGTEAFEKVIFMLDIVPTKDNIQEFAMQGNLYPEPIDETAWALPGYLSDDYNIFLVFAPNVLNHWTVTCAQVTIENGHDITEMSNVVPTGTGMNAVAHASKAGAIELLAYFKTLEANGLGHFDDEVWQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNT0</accession>
    <name>F9UNT0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sbcC</name>
        <name evidence="3" type="ordered locus">lp_1548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101461.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889383.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1548"/>
    <dbReference type="EnsemblBacteria" id="CCC78869">
        <property type="protein sequence ID" value="CCC78869"/>
        <property type="gene ID" value="lp_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1548"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1303"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_2_1_9"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="PhylomeDB" id="F9UNT0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1330-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="706"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117997" checksum="7B827BAFEC5D5FE4" modified="2011-10-19" version="1">MKPVYLAMNYFGPHEHSIIDFSKLESTPIFLISGDTGAGKSTIFDAMTFALFGSTTNDGTDGRAAKEMRSQFAPADQPTSVTFYFEQGNQLYKIARSPEQYLAKKKGSGLTKKNSTAKLAVVDHVGGVEIESIATKPADVGPEITTILNLTADQFKKIILLPQNDFSEFLKSKTTDKEKILKKIFGTQLYSDFTAELKAEYQTASKTGDQFVADLRVALASATWNDEEQAQLQAVPDNQKIPLLRAFVTTRQSAFDQAQQTTSKINRSVKAAETTYQQARDRQQQFDRLTQAQADYQTKVEEQTPAITIAKQQLHALTWAQPLQATMQALTQQTRDQKQLTLDQQAAMDNVQQAQDDYRQAQAAVQQLHDQSEANHQHQQRLEQLATLIPQAQRVESLIAQLAKLKPSVADLKATFEQHQTVIKTLTAKITTQQANLPSIDDLHATKDLLIKQREQFVDTLTPLDSQWRGAQQEQQRVTKQLTDLRAQLASDEQNQHNAQVQFEQQRGQRQSLMIAQLQQELVDGQPCVVCGSTDHSQMPVTTIVANEADLRQSMQAVDDAQNALAAANKQVEATQQRVEQAEKEVDQATQQVTTAQTQLTSTYQQLIETNGLALKSPYDLTAVRAFFAEQLATITKKLEAAQRVVQAIEKYTAELEAQQKQAQQTELQLGEQRALLRNKTADLTVAQAAIGTDLQVTSADLLAEKAHLNQIVATYQQRLEAAQATVQTSQLTLSKHQTKLDDLNDRLKTTQATRTQLEQTIAQALAAPEAPTHDQTVLENWLEELANGRLTALQVQIATYRQDKERLTTEIKQLQTALTNVERPNITGIQAQLADLQAHKDRALQSQTVAEQALTDAQSCLEKVQQIMHQQGTFAKRFAEITSLYNIMTGKDGNDHKLKLETYVVQNYLQRVLNYANDHFINLLSNNRYTFELAAEASDNRSDHGLDINVYDNETGNSRSSNTLSGGETFIAALSIALSLSEVVQSSANGVQIDALFVDEGFGSLDDETLEKAMQALETIGENRMVGVISHIESMKRTIGQQVLIKKMGDGRSTVRLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV0</accession>
    <name>F9UNV0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-bound protease, rhomboid family</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889403.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1571"/>
    <dbReference type="EnsemblBacteria" id="CCC78889">
        <property type="protein sequence ID" value="CCC78889"/>
        <property type="gene ID" value="lp_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1571"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1323"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_3_2_9"/>
    <dbReference type="OMA" id="IGWEHFL"/>
    <dbReference type="PhylomeDB" id="F9UNV0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1350-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="52"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="227" mass="24995" checksum="98B0DE77D0D36053" modified="2011-10-19" version="1">MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLVTPMFLHMGLTHIALNGVVIYFMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVGASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNLVFDMFSNGIDIWGHVGGLVGGFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP52</accession>
    <name>F9UP52_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug resistance transport protein, major facilitator superfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101509.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1689"/>
    <dbReference type="EnsemblBacteria" id="CCC78991">
        <property type="protein sequence ID" value="CCC78991"/>
        <property type="gene ID" value="lp_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1689"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1427"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_9"/>
    <dbReference type="OMA" id="IWGMVIG"/>
    <dbReference type="PhylomeDB" id="F9UP52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1454-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="567" mass="60496" checksum="BFD1588B878C9138" modified="2011-10-19" version="1">MMKKSTKVIAMMMIGIFLCMLDTTVMNIALPAIQTGLNTDLTHLSWALNIYTVLFASLAIPLGRLADVWGRGRMYLIGLGLFGIGSLTSGLSLSVGLLITGRAIQSIGAAIVFPASMTIGIQSVALSRRTGVIASLGVMQGLAAALGPTIGGAVTQFWGWRGIFLINVPLVAVALCGCIAWLSWRHPSHGQVKLDLGGSALVMTTLLALTLVLVKGNDWGWTSRVVLSLGVTSALTLIAFVWMEAHVSAPMVPLALFKDRQFNGAALATVLSGVFMVGLLVLMPSFFTKVQSKTELMAAIMITPASMMIFIFSPISGFLLAKLGARRVIFSGSLAIATGYGVLSLMSPSQYWQFALAALLVGAGYGTIIGPITVLAAGDFTGELLTASQSVIGVFRQIGTSLAVAIFVSALAANLTTAKTQIRTYATTTVTTLSIPKQAKRDTLRVVDHQLATEQTAQTVHEPITAAKARRLVAANYMQVLKARSLQSAPVRIKAQIHQQVAQKVHSQVKHTNHRIRTAASAIKAKTKIELTAAFMRPYQVAWPFTLLLVMTTWCFAGRERKSGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC1</accession>
    <name>F9UPC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644383.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889574.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1771"/>
    <dbReference type="DNASU" id="1061654"/>
    <dbReference type="EnsemblBacteria" id="CCC79060">
        <property type="protein sequence ID" value="CCC79060"/>
        <property type="gene ID" value="lp_1771"/>
    </dbReference>
    <dbReference type="GeneID" id="57025386"/>
    <dbReference type="GeneID" id="66449621"/>
    <dbReference type="KEGG" id="lpl:lp_1771"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1494"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="YLTIWLF"/>
    <dbReference type="PhylomeDB" id="F9UPC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1523-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="25646" checksum="FA701D5DE869F809" modified="2011-10-19" version="1">MMRVEHLAYQFSRNGQPFFKDVSFQLKSPGVNFLIGQNGAGKTTLADIITGLRPAQGELDLPKAAIYLNQQLPLLSSIRVRDVAQLVLGIEHGRLRLTTEQLQQLIDTQAYQFLAPLWDQHYGQLSGGQRKLVQLLLFLQVDRELIVLDEPTAAVDRENVQLLFQVMQAHPERTYLMITHDVRDLHAFTDYQVLWLNDRQVTTLSKRTFEAASAQADFVALFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG2</accession>
    <name>F9UPG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribitolphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tarL</name>
        <name evidence="6" type="ordered locus">lp_1819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645039.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1819"/>
    <dbReference type="EnsemblBacteria" id="CCC79101">
        <property type="protein sequence ID" value="CCC79101"/>
        <property type="gene ID" value="lp_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1819"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1537"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029598_3_1_9"/>
    <dbReference type="OMA" id="VCFEYAL"/>
    <dbReference type="PhylomeDB" id="F9UPG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1564-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="632" mass="73284" checksum="B8A29FCD8EF5801D" modified="2011-10-19" version="1">MIQRLKRIARRIVYGRNQPQYTRNRELVEDAQTTKEDVDFLNTLRIEKDAESLIKRQVTKLEFNSSYLVIEGMAWFEKYPEQDTERIIKSLILTSKTNEELEIPLINVRGQNADFPYAGYHGDINFSTLSEGKPLTPGTYEIKIQLKQYLGNGWIIRRTSIGQVVETQQDLNYTTKMTSYSAKSNKSYSLIFRYNLAAQALKVTSYKLSDVNPLENEFTEDVGLDSVAMRAIKRRALKLWYRWYCLQPIHKKQISFVSDSRVTISGNFEFIYQELKRRNTDFKISFYLKPSIKTKKSWKEVRTLAKALATSRYVILDDFYPLVYPLHIRENADLIQVWHAVGAFKTFGYSRLGMPGGPKVQSLNHRNYTKALVSSHNIADKYAEGFGIAPDKIQPLGIPRTDIFFDEPKKQAIRERLAQDLPFIKGKKVILFAPTFRGNGQQSAYYPFEMLNFRAIYEALHEDYVFLLKIHPFVQNKPTLPYEYSDFYYDVSDYREINDLLLVADQLITDYSSVCFEYALLNRPMIFFAPDLADYMQSRSFYFNYFDFIPGSLAENTGELINQLQHPQVDQAKLDGFVNFFFDDLDGKSTARFVDALENDFEDPNAAELENNDGLAISEDGKIIPDWGKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ6</accession>
    <name>F9UPJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, DUF2140 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101575.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889649.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1866"/>
    <dbReference type="EnsemblBacteria" id="CCC79135">
        <property type="protein sequence ID" value="CCC79135"/>
        <property type="gene ID" value="lp_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1866"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1572"/>
    <dbReference type="eggNOG" id="COG4698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098230_1_0_9"/>
    <dbReference type="OMA" id="NGMYVKA"/>
    <dbReference type="PhylomeDB" id="F9UPJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1597-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018672">
        <property type="entry name" value="DUF2140"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09911">
        <property type="entry name" value="DUF2140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="214" mass="23745" checksum="75B279CB4F86B752" modified="2011-10-19" version="1">MREAQRNKQASASKNPKTNGPINVWKWVAVVLIALIVGTGAYVGTQVLRSPSESTSLTAASNTDAASVPITMNRKQLNALASYYLNDLQKGQDMKYRFVVRSTGAYLLGTTQVLGQNVSFVITMQPSVIDNGNISLKATNLSVGTMSLPISFVINYINNNYKTPKWVKLNAKKKTIDLYLNKLVGKHDVRYSVDKLDLKNNQFKFEMHIPKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN4</accession>
    <name>F9UPN4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC79173">
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    </dbReference>
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    <dbReference type="GeneID" id="66449731"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="18678" checksum="ED8CE5AE0470FDDE" modified="2011-10-19" version="1">MTTNIKAELVAGKLAEYEQLSKIYDDIVKQARPRITVEGQGKILLALADEDHLSQKQLASRLGMSPQSTSEFVYKLVNRQLVTLSKSTKDRRVNLVNLTAAGRKEIASAAQEVPPFVNTLSDDELDQLAPLLTKITTAMYADIDAANPTLGVKFHKLFASRYLKQFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
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    <name>F9UPR4_LACPL</name>
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        </submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889717.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1944"/>
    <dbReference type="EnsemblBacteria" id="CCC79203">
        <property type="protein sequence ID" value="CCC79203"/>
        <property type="gene ID" value="lp_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1944"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1641"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_5_2_9"/>
    <dbReference type="OMA" id="NMVEYYL"/>
    <dbReference type="PhylomeDB" id="F9UPR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1666-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="28258" checksum="9BEE1FAF25216CAE" modified="2011-10-19" version="1">MKILMAQLRFDARRLIIRNAAFQFFALVMPAAFYLLFTKVMVTGGTTAQIALFNRSYMGSMIVYSGTISTLFSIAQILMHDRERGLLRWLRLTPHGVVPYYRSIGMMSLGMNALTVVILGAIAVVVNHVDLTVVQWLGILGIALIGQLPTLLMGVGLSFLNRAETLSVASNLITFPMAIISGLWWPISLLPSWLQVIGKRLPTYYVNDLLVNWGTHGTLKLIDLLGIGLWVCGLLVIVSWVIQRGLKRGNGVVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV8</accession>
    <name>F9UPV8_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">lp_1997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1997"/>
    <dbReference type="EnsemblBacteria" id="CCC79247">
        <property type="protein sequence ID" value="CCC79247"/>
        <property type="gene ID" value="lp_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1997"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_41_3_9"/>
    <dbReference type="OMA" id="DIFENML"/>
    <dbReference type="PhylomeDB" id="F9UPV8"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="12489" checksum="F582391FA07E0758" modified="2011-10-19" version="1">MEESIKCEDQFDSPFICTKQNGKPITPSVIKYYTGKLSRELDFSFNFHSLRHTHATMLLENGAKYKEIQQRLGHSRISTTLDIYSHVTNKMKRDTVDIFENMLKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX0</accession>
    <name>F9UPX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2011a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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        <source>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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                <person name="Boekhorst J."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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                <person name="Nierop Groot M.N."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="21"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="461" mass="50765" checksum="8EBD629E1809D449" modified="2011-10-19" version="1">MTKENSQPATEQLSRGLKSRHVQLIAIGGTIGTGLFLGAGQSIHLAGPAILIAYLVTGLVCFLLMRALGELLLSDLHTHSYIDFIKQYLGDKTGFVAGWTYWVCWITIAMAEITAAGEYMQFWWPRLPQWLPGLIILILLLGLNSINVSAFGETEFWFAIIKIAAILALIAVGIGMVLFSVKTPVGHASLTNLVSYGGFMPHGIKGLVLSFQMVLFSFIGIEMVGMTASETADPKTVIPKAINDIPVRIILFYVGSLFFLMCMYPWQYFSAAHSPFVQVFTNLGIRSAAAIINFVVLTAAASSCNSALFSTGRMLFSLTYDGKSKFAKRMGILSTRQVPRNALWFSTLVIGLSVILNLLMPGKVFSLIASVSTTCFIFIWGAIVVAHIKYRRQAGSQAKVKFRMPLFPLSDYFILVFLAFIAVVLCLKFETLIALLVSAVWVVGLYIVKIVSDRIRQRTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH8</accession>
    <name>F9UQH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889981.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2259"/>
    <dbReference type="EnsemblBacteria" id="CCC79467">
        <property type="protein sequence ID" value="CCC79467"/>
        <property type="gene ID" value="lp_2259"/>
    </dbReference>
    <dbReference type="GeneID" id="57025804"/>
    <dbReference type="KEGG" id="lpl:lp_2259"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1910"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_9"/>
    <dbReference type="OMA" id="CDIPKSK"/>
    <dbReference type="PhylomeDB" id="F9UQH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1952-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="17206" checksum="F47884880193D26A" modified="2011-10-19" version="1">MYSIGAVAKKTGISSYTLRYYDKAGLTPFVKRDKQGRRVFNDEDLDSLALIRCLKQTGMPLEDIRQFISWCADGDGTIDQRLAMFEEQRQAVEAQIHQSLLNLQKVNHKIDVYRRASQAGSEAAVDCDVLPLKTTAALLAEVADYETEHPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM3</accession>
    <name>F9UQM3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septum site-determining protein MinC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">minC</name>
        <name evidence="5" type="ordered locus">lp_2316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890026.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2316"/>
    <dbReference type="DNASU" id="1062325"/>
    <dbReference type="EnsemblBacteria" id="CCC79512">
        <property type="protein sequence ID" value="CCC79512"/>
        <property type="gene ID" value="lp_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2316"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1957"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_1_0_9"/>
    <dbReference type="OMA" id="EMECAYI"/>
    <dbReference type="PhylomeDB" id="F9UQM3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1996-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24693" checksum="5AF3B2364378E1EE" modified="2011-10-19" version="1">MQQSVVLKASNDGYELILRQEASFDDIMVDLKVLLDRLQADNTTDKQISFDLDTASRLLTAEQNQKVTQLIQRYPLFSIHKLTADVILTADALAMIERDTVHLVNQIIRNGQVVEITGDVLFFGKIHEGGVLRATGSIFVMGEVNGALEAGYPDHNDAVIVSPLATVPRVRVGELLELVDLEKVVDGTNVVYINDIQALDYQPLQQLKRVRPKLFTRNGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM5</accession>
    <name>F9UQM5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mreC</name>
        <name evidence="8" type="ordered locus">lp_2318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2318"/>
    <dbReference type="EnsemblBacteria" id="CCC79514">
        <property type="protein sequence ID" value="CCC79514"/>
        <property type="gene ID" value="lp_2318"/>
    </dbReference>
    <dbReference type="GeneID" id="57025850"/>
    <dbReference type="KEGG" id="lpl:lp_2318"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1959"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_042663_1_1_9"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="PhylomeDB" id="F9UQM5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1998-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394400" description="Cell shape-determining protein MreC" evidence="7">
        <location>
            <begin position="30"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="281" mass="30127" checksum="5501601299DB8A8F" modified="2011-10-19" version="1">MQKFFSNRKLVIAIVVFIISFGLMSVSVAIRDKKSTPPLIQQFGNDVAGAVDRVIAWPVNGLQSATNSVSDLLNTYQENQKLKKQVDQLAQAKVSAQTTRAENKQLRKQLKLNNSLSDYTTVTANVLTRTPSSWMNQLVISKGATSGVKKNMPVMSQKGLIGRVVEVNQTNSKVELISNTSSSSNKFAIQITNSAGKTVNGIISGYDKSNNLLEMGSVTSNVKIKKGDKVVTSGLGGNTPKGLYVGTVASVKQDDYGLASEVEITPAADLSDLTVVTVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
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    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2418"/>
    <dbReference type="EnsemblBacteria" id="CCC79597">
        <property type="protein sequence ID" value="CCC79597"/>
        <property type="gene ID" value="lp_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2418"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2044"/>
    <dbReference type="eggNOG" id="ENOG5032REC">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281866_0_0_9"/>
    <dbReference type="OMA" id="SRNELYQ"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025580">
        <property type="entry name" value="DUF4355"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14265">
        <property type="entry name" value="DUF4355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="23945" checksum="912067BE5DE1DE66" modified="2011-10-19" version="1">MSEEPKNPETNPEGGQQSDEPVTFTDEQQAKIDELIGQQHAKWSKKLDRQQADFKQQLVVAQKQAEERAKMTADQKAEADRKQHEADMAKKNQELATQIQEYKTKSMLLDKGISPDMLPLVMGADEDSTSDNLGLLQKYVDDQVQAATEKLLAGKQAVTTGSNNTSSQEAGTNNPWSKDGWNLTKQTEIYNTDKEQAQKLIASAQPISQSFYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX8</accession>
    <name>F9UQX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101769.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2439"/>
    <dbReference type="EnsemblBacteria" id="CCC79617">
        <property type="protein sequence ID" value="CCC79617"/>
        <property type="gene ID" value="lp_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2439"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2061"/>
    <dbReference type="eggNOG" id="ENOG5030A6B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109773_0_0_9"/>
    <dbReference type="OMA" id="QSIRRFN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2103-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007731">
        <property type="entry name" value="DUF669"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05037">
        <property type="entry name" value="DUF669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="23401" checksum="A39869C894B313CE" modified="2011-10-19" version="1">MALFTVDTNNILGQAVEEAGTYNVVVAPSSQYTTTQQAGNPMAVFDYEVLDGKYKGGRIRFDNEVWDTSTEEKGNLSIKRFNTIAVALGAANGTSFDSIQQFVSQAVGNKLAVTVDWETGQNGKTYLSVKSHKPFMQDGSKPNGVKRPNGSSTQSGGFAPRNSSGFGGQNHNNGFGSTSAPNPSNNSVPKQQGNNNSFANQTGAGYKGGQPFDNVPDGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ1</accession>
    <name>F9UQZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79630.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890144.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79630">
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    </dbReference>
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            <dbReference type="EMBL" id="CCC79630.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="58" mass="6934" checksum="52B5D5C7D521400D" modified="2011-10-19" version="1">MDSEISKYELIATMKKDIQTFMDSESMLYLKKDSYSTEEYDRMLTEVKDALKTRLLQK</sequence>
</entry>
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            <fullName evidence="1">Prophage P2b protein 8, helicase</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890160.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2473"/>
    <dbReference type="EnsemblBacteria" id="CCC79646">
        <property type="protein sequence ID" value="CCC79646"/>
        <property type="gene ID" value="lp_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2473"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2084"/>
    <dbReference type="eggNOG" id="COG5545">
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    <dbReference type="OMA" id="MDNMDGW"/>
    <dbReference type="PhylomeDB" id="F9UR07"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2138-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="464" mass="53602" checksum="1573039A46F093D3" modified="2011-10-19" version="1">MGKAMDLPAETREAANNVIKMQRDADWQNDFKKNSDDGIKTQSLYNIRLIMEHDEMLKGLVAFDEFSEQIVKTPQAENSLFKKGFWNDGDDTLLRSYIEDHYNLLFSKENITDAVVTEARRKTINPVKARIEAVEWDGQPRAERYFINYLGAEDNHYTRTITKKWLTGLIARAYVPGVKFEIVPILEGSQGLGKSTAGKNLYPDKFNDSLKGMGKQKDDYQQLQGSWIIEVAELSAMKKTDIEGIKNFISAQSDTYRNSYGRYALPHPRKCVFIGTTNQTDYLKDATGERRFYPIKCGVNKAKLDVWHPDENYMLQVLAEAAYWFKNGEPLYLDQATMKEAKAYQMAAEAVDPMRDAIEAFLAMEVPTDWENMSTSLKQSYVSDYGHHSKWLQDQVSNERKLLNQTTTREIMEVVFHKTVDRYLTGRTNSEAKRIKLLMDNMDGWKSQRIRMNGQRLHGYMREV</sequence>
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    <accession>F9UR84</accession>
    <name>F9UR84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ordered locus">lp_2569</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890237.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2569"/>
    <dbReference type="EnsemblBacteria" id="CCC79723">
        <property type="protein sequence ID" value="CCC79723"/>
        <property type="gene ID" value="lp_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2569"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2159"/>
    <dbReference type="eggNOG" id="COG3832">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108920_1_0_9"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19396" checksum="8141B8C09B5C0D56" modified="2011-10-19" version="1">MKSINWSTDYLPGHTDNFVSNEVITDGVTLAAVWKNLVDTSKWTTYYDNATNIILDDQTNTELKFAEHFRFDTFGFPIDAQVMELVEPTDGETARLAWHGWQNGDADTQFDVYHAFLIEKLTDGRIRLLTQESQVGQPAKDLANQTPNPMLNGHQSWLDGLVKAAKRTMTE</sequence>
</entry>
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    <accession>F9URE8</accession>
    <name>F9URE8_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 1 (GT1)</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_2658</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2658"/>
    <dbReference type="EnsemblBacteria" id="CCC79787">
        <property type="protein sequence ID" value="CCC79787"/>
        <property type="gene ID" value="lp_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2658"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2226"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="43568" checksum="5619F291595BEC1E" modified="2011-10-19" version="1">MFNRQSTMLMKILITVENLVMDGVKRAATVLGNALTSQAEVAFYSLAQPRSFYELSAPLITARRPASATVLNYFGADPLTVYAPQIDDLLTTIGSGAYDAVILPGGLLTSFAPAIKQRFPRVNVIAWMHNNVDIYLNQYYVQMQDELVAGLLAADTVVTLTDYDWEGYSRFNAHTVKFYNPPTMQAHGQQADLAQHIIAYTGRIDLQHKGLDYLLTVARALPDDWQIAVAGTGPEDQLATFNRLMAELDVRDRIIYRGALKDTELRAHYQQASVFMMTSRWEGMPLVMGEAMTMGLPIVSMWNTGSAEYLQGGQYGVLTPARDVNALITGLMPLLTDFDCRAEYAARARQRSHDFTLSKIVRQWLALLNRQYVPQTVVESNWPADLSSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH5</accession>
    <name>F9URH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890328.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79814">
        <property type="protein sequence ID" value="CCC79814"/>
        <property type="gene ID" value="lp_2691"/>
    </dbReference>
    <dbReference type="GeneID" id="57026074"/>
    <dbReference type="KEGG" id="lpl:lp_2691"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2253"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_13_0_9"/>
    <dbReference type="OMA" id="QWNEHYP"/>
    <dbReference type="PhylomeDB" id="F9URH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2305-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="19778" checksum="A268D738FAF68C17" modified="2011-10-19" version="1">MSKYIRQATSADLPAMMAIIEQGKHALAADQIPQWQDGYPLAADIQADIDARIAWVLIVDDQIAGTAALLTTPDPNYAIIYDGSWAPTENHRYASIHRIAIANGYHGQHLTDFYFSNLITMSYQLGFRQLRIDTHLLNKRMQHIITKAGFEYRGIVYMNHDNNDQRNAYQLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT7</accession>
    <name>F9URT7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mleP3</name>
        <name evidence="8" type="ordered locus">lp_2829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644751.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2829"/>
    <dbReference type="DNASU" id="1063198"/>
    <dbReference type="EnsemblBacteria" id="CCC79926">
        <property type="protein sequence ID" value="CCC79926"/>
        <property type="gene ID" value="lp_2829"/>
    </dbReference>
    <dbReference type="GeneID" id="57026191"/>
    <dbReference type="KEGG" id="lpl:lp_2829"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2367"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_0_9"/>
    <dbReference type="OMA" id="LAMWITY"/>
    <dbReference type="PhylomeDB" id="F9URT7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2423-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="308" mass="33636" checksum="950628E29B9E7ED8" modified="2011-10-19" version="1">MNLTQLTSQIILMFILMLVGLLVNKLGFMHAQTSTDLTNILLYIVSPCLIIQAFEKTFSADRLQMLARVIAGIVIIYVLMIIVTQLLFKRVSDQNLRRIMRYGAVYSNAGFMGIPLTSSLFGATGVFYAVASLAAFNIFSWTHGITLFTGQQGNRRDNLKQIVFNPNIIAIVVGLLIFVTSLQLPTIANSAIKYVSSVNTPLSMIVIGNSLADVKLNRATLDKRLWLVILLRNLLFPYLAIVVLQLMGITGIPLFTTVLMAACPVAGIVVLFSLKVHGDPGPAVALMSISTILSVVTIPIVFALVNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU3</accession>
    <name>F9URU3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein serine-acetylating enzyme</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890446.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2840"/>
    <dbReference type="EnsemblBacteria" id="CCC79932">
        <property type="protein sequence ID" value="CCC79932"/>
        <property type="gene ID" value="lp_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2840"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2374"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9URU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2429-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="185" mass="20816" checksum="9EC09F13ABF567DC" modified="2011-10-19" version="1">MLTYRVTPAIELREPLPQSDAPALLALLTADRAQYQYYLPWVAKIQTVADEQRFLTFAQAQLQQAQALNLVIVVEQRVVGMVSCDHFDDNDHSANIGYWLGRPFQGRGVMTAAVRGVCDLGFNQYHRQCLRIRAAVDNQASNAVAQRAGFDFLIQHPGGQHLLDGDHDENVYQVSAVDWLAKRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ4</accession>
    <name>F9URZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890497.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2902"/>
    <dbReference type="DNASU" id="1063289"/>
    <dbReference type="EnsemblBacteria" id="CCC79983">
        <property type="protein sequence ID" value="CCC79983"/>
        <property type="gene ID" value="lp_2902"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2902"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2425"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_3_2_9"/>
    <dbReference type="OMA" id="QFGAENL"/>
    <dbReference type="PhylomeDB" id="F9URZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2479-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="24456" checksum="D55D2AB3AC0401A1" modified="2011-10-19" version="1">MNTSNRCTGMQRCFYGNYILLFEYKNLKNGVMVISIRTELDLQRAMYQLLEQRSISQITVEQICKQAFIHRSSFYRYYTDKFDLLRQMVMHTLDELLAAERTNTVGSAIMSTFIGAHTQVLRHLLVTNNEGDNTRSQQVINDCFVTVAETGADDRVFAMIRQSQHPDLTAYLVSGVVTSIVQWLNNGHRDGQAASTQAMIQGTLATVFSLEQHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ9</accession>
    <name>F9URZ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound protease, CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2911"/>
    <dbReference type="EnsemblBacteria" id="CCC79988">
        <property type="protein sequence ID" value="CCC79988"/>
        <property type="gene ID" value="lp_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2911"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2430"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044196_1_0_9"/>
    <dbReference type="OMA" id="GMAYLMV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2484-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="44562" checksum="93112553AAFA52D9" modified="2011-10-19" version="1">MTPETEQLLRRWYMGQLIVLFGAAFIQLFTFDGGVFFPVGGMQLLIWGLLAWWPAAEEDQAQWRRLRHVNYYVQTVLQFTLLPILLANLVAWLSQLSWLDEQGLIAVGMAYLMVAFVPVAVVVTKPIESVIGRIAVLITAIFSGVVSAQQTFLILPNLQAPSVFEMVSDTGILGALGFVIAVGVLLRGWGLTGPSWRFNRQAQTSLVVGLIVVGTAFSLWNAFSAGGSWATTFTHWDFQLRSATWKMFLSGLEPGIAEEWLYRFAVLTLLLQAFRHRRHQLDLAVWLSGGLFGMWHITNVFAGQPLSATVEQIIFAATLGWFLASTYLYSGSILLPMVIHAAIDILSMMASGSQTMVKPDAFEWQTIGATVIIFVGITIYFLTGSRRQVIQAHVNQRLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9US12</accession>
    <name>F9US12_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2925"/>
    <dbReference type="EnsemblBacteria" id="CCC80001">
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        <property type="gene ID" value="lp_2925"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.2443"/>
    <dbReference type="eggNOG" id="ENOG502ZB4C">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_017995_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2497-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04215">
        <property type="entry name" value="choice_anch_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394406" evidence="3">
        <location>
            <begin position="37"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="833" mass="89527" checksum="45A18C17B7A350FA" modified="2011-10-19" version="1">MERKRTNFKMYKIGRRWAFACAVILTMGTTTLVARADDGTTATGTDTASTSSSTTKSVTAKTQTLKTAATTEADVTNQNQPVLDTDGSNSKTAAGTVAGTKAATDTDTNATTNLDETTSANTETGSDTTAGSKTAKETNATTGSESTKETSTITDSATATAARTTTSSNKGATTDSTTSHDTAATATKTTDASSKIAGTTTSDSVAQQTTTTKDQSTTTATPQTAAVALSQAVTHANDAVADGGNVTDDYPDLHNMLRVSSQFHIFAREAELHAHTNGNVAVQNLVGNVNFGTNIIEELLDKDISYIQNISNIAGSSFVSAGETRSNKVIFGENIEIDISNPNRPMVNGVYIDHLLASEVYQDKDGNVYIDFDKEFAKLEQLSASLSEASANVTYTSDSFEDMNQRVIDVTDMQPDADGHIVINLSADVLNTSTPLTIKGLSADADGNTVIINVDTAGATNYQVNSQIKIIYDDGTERNNKETEDFGDNHLLWNFYDSTASDKLATGVINVDRPFQGSILAPAAEIDANQNIDGNIIANKVNVKAETHRWDLQDNVDNENDPEPVPDYEKPVHPSIDAELPDGGEGEEPEYDKPVHPSIDIEMPDDGEGEEPEYDKPVHPSIDIEMPDDGEEEEPEYDKPVHPSIDIEMPDNGEEEEEYDKPVHPSIDVEMPDFDEIEDEEEAEDAEEEFEDDIEDEIEAGVTPDEVVDQIEEEVDNEITADWVTDETATELETAFEEVQKEAVVGDQIKDEETLINLIDRAIAQAKAHHNTALVAQLQALRTKVASALAVAKGQALPQTDEAPSQMISLAGIALASTLVLGAAAVSRRKRQY</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100860.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888134.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0053"/>
    <dbReference type="EnsemblBacteria" id="CCC77620">
        <property type="protein sequence ID" value="CCC77620"/>
        <property type="gene ID" value="lp_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0053"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.42"/>
    <dbReference type="eggNOG" id="ENOG5032UHI">
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    <dbReference type="HOGENOM" id="CLU_088205_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9US73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-42-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.250">
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    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010841">
        <property type="entry name" value="EF-G-binding_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038344">
        <property type="entry name" value="EF-G_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07299">
        <property type="entry name" value="EF-G-binding_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-G-binding_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FBP_C" evidence="2">
        <location>
            <begin position="100"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="24084" checksum="400D6055BC174D38" modified="2011-10-19" version="1">MQPTITTYQYSYITQQVNQLISAELAVNDLQIRAVVRAQAIKRITPLLPSDNPITANFLSHLQTDRLTRAKAPQLLETLIPLIIPFPSLTTKQLSKLFRKVKKLKQPVWSQLALRELTYLGWNDGGNQKKYLVIPDHDRLIGIQGDLAPQTVKGVCAICQTIGNVALFMSTTKSSGLGPYTRNGNYICRDSNQCNRQLTNPQALADFLAVVRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9US86</accession>
    <name>F9US86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein, DUF1212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641680.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0068"/>
    <dbReference type="EnsemblBacteria" id="CCC77633">
        <property type="protein sequence ID" value="CCC77633"/>
        <property type="gene ID" value="lp_0068"/>
    </dbReference>
    <dbReference type="GeneID" id="57026918"/>
    <dbReference type="KEGG" id="lpl:lp_0068"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.55"/>
    <dbReference type="eggNOG" id="COG2966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="MLSCGTG"/>
    <dbReference type="PhylomeDB" id="F9US86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-55-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
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        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
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        <location>
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            <end position="290"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
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        <location>
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            <end position="373"/>
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    </feature>
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        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="6">
        <location>
            <begin position="43"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="312"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="447" mass="48770" checksum="C2A5F0D0357D0496" modified="2011-10-19" version="1">MNKERKSVMPLSQRHHMTIPWKDFIRNEDVPAKHASLQERTSIVGRVGILMLSCGTGAWRVRDAMNKIARSLNLTCSADIGLISIQYTCFHHERSYTQVLSIPNTGVNTDKLNILEQFVKDFDAKYARLTVAQVHAAIDEVQTRPKQYSPLVLGLAAGLACSGFIFLLGGGIPEMICSFLGAGLGNYVRALMGKRSMTTVAGIAVSVAVACLAYMVSFKIFEYNFQILAQHEAGYIGAMLFVIPGFPFITSMLDISKLDMRSGLERLAYAIMVTLIATLVGWLVATLVSFKPADFLPLGLSPLAVLLLRLPASFCGVYGFSIMFNSSQKMAITAGFIGAIANTLRLELVDLTAMPPAAAAFCGALVAGLIASVVNRYNGYPRISLTVPSIVIMVPGLYIYRAIYSIGNNQIGVGSLWLTKAVLIIMFLPLGLFVARALLDHEWRHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2977"/>
    <dbReference type="EnsemblBacteria" id="CCC80039">
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        <property type="gene ID" value="lp_2977"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2977"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="26"/>
        </location>
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    <feature type="domain" description="DUF3324" evidence="3">
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            <begin position="171"/>
            <end position="304"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="347" mass="38044" checksum="9E0565CA0CD16F42" modified="2011-10-19" version="1">MKKMMRWLGAILVMISGLSAVVPAQATNTDTSNNIGFSVAAQTPKNQIDKQATFFDLKMTAGQTQTLQTRIYNTTNRDIRVAMGIHTAYTNSGGAIEYVTPAKKYDASLQYRVDQLTKIKGPTTVTVPANGSKLVSAQTTMPTKDFNGALLGGWYFKRVDQKVTGEVKGATNISSEYSYVVGIKYSLGTAPTPVLKLSDVAAGMVNYHRSIVVTLRNTAAVMIPRVTMKTTVTAKDSGKTVVKATKQGVMLAPNTTFNYPLLLNKQKLQAGTYHLHLVAHNSAHKWTFDRDFKISAATAKTYNQDTVDDNGISIWWLIGLGALGMLIVVLLILWLVLFLKKRRQSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC4</accession>
    <name>F9USC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80054.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890568.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2994"/>
    <dbReference type="EnsemblBacteria" id="CCC80054">
        <property type="protein sequence ID" value="CCC80054"/>
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    </dbReference>
    <dbReference type="GeneID" id="66450592"/>
    <dbReference type="KEGG" id="lpl:lp_2994"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2499"/>
    <dbReference type="eggNOG" id="ENOG5030AAY">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188349_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2549-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="10339" checksum="789AC4EAD912541E" modified="2011-10-19" version="1">MTPNETYDALEQWHLLPATNFTWRPFTATAIYVDSPHARRVYQLDLADDTVEIFQADPGSELSEHFLPYKTVTLTTTQINQFKHTQPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE8</accession>
    <name>F9USE8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase, GGDEF domain</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_3021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890592.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3021"/>
    <dbReference type="EnsemblBacteria" id="CCC80078">
        <property type="protein sequence ID" value="CCC80078"/>
        <property type="gene ID" value="lp_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3021"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2524"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_9"/>
    <dbReference type="OMA" id="NDAWIFM"/>
    <dbReference type="PhylomeDB" id="F9USE8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2572-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
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    </dbReference>
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        <property type="entry name" value="GGDEF"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="244"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="378" mass="43849" checksum="6275C53D82D5774D" modified="2011-10-19" version="1">MTWSHWEITPFITSVFFILGVLTLFWVSQNWIINFFNTHHWRVDQSLITDWYGLIYMMLFVFGMQTAVVGQNDAWIFMNFQLIGLTFCGYFLNVRVRYYYLYPLVFIFMGFNHSLYYWESWGHAVTLILFFTALGRLRKHVPLQTKQGQVTLYLVTCAGFGAVLWWFMKLKFNLSWATYWQEWTYLLVFASLLYIYASMLSANAHLKQNLVAFANHDALTKIENFAAYKTAINYQVTSSRKNGSQLTMLMFDIDHFKQVNDTYGHLAGDKILQHVAQVATIVFHANNPQISLYRTGGEEFNVIFPNYDLTEALAVAEQLFAAINHIAVPVNDHQIQLSISIGLSELAADDQSPTAFYQRVDANLYHSKKHGRMQITAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH3</accession>
    <name>F9USH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,3-propanediol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.202</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dhaT</name>
        <name evidence="3" type="ordered locus">lp_3051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.202" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890617.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USH3"/>
    <dbReference type="STRING" id="220668.lp_3051"/>
    <dbReference type="EnsemblBacteria" id="CCC80103">
        <property type="protein sequence ID" value="CCC80103"/>
        <property type="gene ID" value="lp_3051"/>
    </dbReference>
    <dbReference type="GeneID" id="66450629"/>
    <dbReference type="KEGG" id="lpl:lp_3051"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2550"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_9"/>
    <dbReference type="OMA" id="WLRYVIT"/>
    <dbReference type="PhylomeDB" id="F9USH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2596-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047516">
        <property type="term" value="F:1,3-propanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="390" mass="42159" checksum="3767EA846B329852" modified="2011-10-19" version="1">MTERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLDAAGIDYVIYNQVEPNPKIHNIQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDDITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEETHYKFVVASWRNMPLVSFNDPTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHNLEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIACPERFAELAKIMGENTDGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATNALKDGNAFSNPRKGTKEDIIKIFQAAYDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH6</accession>
    <name>F9USH6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642309.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890620.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3057"/>
    <dbReference type="EnsemblBacteria" id="CCC80106">
        <property type="protein sequence ID" value="CCC80106"/>
        <property type="gene ID" value="lp_3057"/>
    </dbReference>
    <dbReference type="GeneID" id="66450632"/>
    <dbReference type="KEGG" id="lpl:lp_3057"/>
    <dbReference type="eggNOG" id="COG4633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131523_1_0_9"/>
    <dbReference type="OMA" id="HGYKPDT"/>
    <dbReference type="PhylomeDB" id="F9USH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2599-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="5EF8587ACDC8FD7C" modified="2011-10-19" version="1">MSARQQINITVDGHYDPAEVTLQQGVPAQLTFTRTSTQGCLEQVHSTDLHFTTELPLDQPQTVTVPTDRAGEFYFSCGMDMVSGKVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK4</accession>
    <name>F9USK4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-03" db="PDB data bank">
            <title>Crystal structure of putative transcription regulator from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Chang C."/>
                <person name="Bigelow L."/>
                <person name="Freeman L."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642336.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890648.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3COL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=1-193"/>
    </dbReference>
    <dbReference type="PDBsum" id="3COL"/>
    <dbReference type="SMR" id="F9USK4"/>
    <dbReference type="STRING" id="220668.lp_3090"/>
    <dbReference type="DNASU" id="1063616"/>
    <dbReference type="EnsemblBacteria" id="CCC80134">
        <property type="protein sequence ID" value="CCC80134"/>
        <property type="gene ID" value="lp_3090"/>
    </dbReference>
    <dbReference type="GeneID" id="57026400"/>
    <dbReference type="KEGG" id="lpl:lp_3090"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2580"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_9"/>
    <dbReference type="OMA" id="FAYASKN"/>
    <dbReference type="PhylomeDB" id="F9USK4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2627-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3COL"/>
        </source>
    </evidence>
    <sequence length="193" mass="21370" checksum="4C857887BC9FAAA2" modified="2011-10-19" version="1">MKKKDMNKQVKIQDAVAAIILAEGPAGVSTTKVAKRVGIAQSNVYLYFKNKQALIDSVYARETNRILSTTDLDRLSDSTIDVTTRIRLYVQQVYDYSLANPDSLTIIQQIKALNGQGMTISAADADPNNIVANLLTAAIDAKVIKQLPVSLHMGVVFSTIHTHTTNISKGRYAQDQYTFGDIFQMIWDAMKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN7</accession>
    <name>F9USN7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mucus-binding protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102054.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890681.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3127"/>
    <dbReference type="EnsemblBacteria" id="CCC80167">
        <property type="protein sequence ID" value="CCC80167"/>
        <property type="gene ID" value="lp_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3127"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2615"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272002_0_0_9"/>
    <dbReference type="OMA" id="NYTHVET"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2660-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389013" evidence="8">
        <location>
            <begin position="38"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1189" mass="123514" checksum="3DA7F65DAD3489BC" modified="2011-10-19" version="1">MNKRKIITNNPPKWHLITGIAATILASIILTNQDAFAATDSTTAPTTTAPTVQQTAPTNPLSGSQVTLTSTTGSSATGSTTTSSPVATSTAAMPVKSTATSGSLMSAMASTSATSGHAAEPSSSVTEAASTNNLIPTSAAMASSATTKYPTDTTATPNASSSLTSAESSTPNKAMSTSQQTVSSGVIHSTTPASSASMPVPTSVAETASAAAPSVTNSTAANSTAPTSVMTTDSAAESVPLSTSSETSSEKLAAASTTSTSQISDGSEVIHPMTSAISSSSSAPTSGAKMAASAASAASASVITSAVNSIAASTYSADASAASVESAATPDTSHATVPASTATSAATTFQITSVINSLASSTYSEYAEQANAEAASAATTAEKPATSVGTVVPTAATTPTESIDTWMPNKHLQEAVLRELQALKLPDHQFKSVNDITKDDMQLLTQFYGENTYIDGHTPYSLEGLQYATNLKTIWLNNGLNALGGYYNGDVTDISPLAGLTKLTVLNIQHNRVSDLSPIAHLTNLQELDVAYNHIADLSVFKDLPNLKTTTYLGQTILEPLVYVDQDTTSATLKNRFYLPNGQQAVLKSQAAILKPVQLTPNGQFYYRFYFNGAGKAVNGDLSNVVPDGQGGLTFNQLVPQIPGFTGDANGQFVTNGVSINVVPNDKNFYLVAQGSDGSSPVFHVFQPYVLAAKAAPVTIHHIDRNGAALRDSEELTGLVGEDYQSTPADITNYTHVETQGAPQGTFSAEPQAVTYVYDKTAGAPVTVSYQDEQGKTLQPDTTCNGLAGDPYTTKPLEIAGYDLTKTPDNAAGTFTAEPQHVIYIYTKQVPQPVTASYQDEDGKALQPDITHTGEIGAAYETKALEIPDYDLVKTIGNATGTFTKEPQQVTYIYTKQIPQPVTASYQDEDGKTLQPDITHTGEIGAAYETKALEIPGYQLIKTPTNATGSFTKEPQHVLYVYEKQAVLPVTVSYQDADGKPLHADIVLSGDFGQNYQTEQLSIPGYVFNKVVGPTIGTFGTTAQHVVYTYTPEPSGPEQPTPGPEPEPVPEPQPTPAPQPEPTPQPSPTPQPSPAPQPNPAPQPSPVPQPNPAPQPGSSLLAKAPVSQGTTTSQSSPTTSPQPTPIAPVSALAQPGKQQAPATVATHNSGQLPQTSEQSEHGATLGGILAALFTGLGWLGLAAKFKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX1</accession>
    <name>F9USX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641754.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0158"/>
    <dbReference type="EnsemblBacteria" id="CCC77702">
        <property type="protein sequence ID" value="CCC77702"/>
        <property type="gene ID" value="lp_0158"/>
    </dbReference>
    <dbReference type="GeneID" id="57026989"/>
    <dbReference type="GeneID" id="66448285"/>
    <dbReference type="KEGG" id="lpl:lp_0158"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.127"/>
    <dbReference type="eggNOG" id="ENOG503328X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074053_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9USX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-124-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="18603" checksum="96AA8206428E0CD8" modified="2011-10-19" version="1">MRLKDLTGETFSRLTVIERAESAPNGNARWLCQCSCGRQVVVDSYRLRKGITKSCGCLRADVSRKNIFENPQTRKNMGRSDNLPLYQGTSVDRLKPNSRNRSGVIGVSFDRCSQKWVARLMYRGRLVLNQQFADMDDAIMARKQAEQRYVMPVLEEYAKSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT25</accession>
    <name>F9UT25_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpo</name>
        <name evidence="6" type="ordered locus">lp_0220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646371.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888270.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0220"/>
    <dbReference type="PeroxiBase" id="5461">
        <property type="entry name" value="LplGPx01"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77756">
        <property type="protein sequence ID" value="CCC77756"/>
        <property type="gene ID" value="lp_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="57027043"/>
    <dbReference type="GeneID" id="66448334"/>
    <dbReference type="KEGG" id="lpl:lp_0220"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.183"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_9"/>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="PhylomeDB" id="F9UT25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-178-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18230" checksum="D9FB5055E5AC18F2" modified="2011-10-19" version="1">MAESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVVLGLPSNQFHQEKADDDETHDYCQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIKWNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE9</accession>
    <name>F9UTE9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.17" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890781.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3251"/>
    <dbReference type="EnsemblBacteria" id="CCC80267">
        <property type="protein sequence ID" value="CCC80267"/>
        <property type="gene ID" value="lp_3251"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3251"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2715"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070320_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UTE9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2755-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="31896" checksum="F435B2BBB3B52BF2" modified="2011-10-19" version="1">MRPLQVIQISDLHLTPRGQVPAHGQQYDPWGKLANIIDDIRRLPTMPDLIVFTGDLIHDGSADDYQRLHAIIHTMEAEFDCHVRVILGNHDRRAAFYEGYLPADPGPYYASRMRIGNNDFYFLDSKVSGYEAGWLAPQQLQWLGKHLRQAPTKRAFLFLHHPLDGPTMTNMHYAILQNTPALLSVLRGHNLGGVFSGHVHFVSSYLIGDNILNVVAGSAAYAIDCHDPHHHYVHEGSSYQIITIDRGQVGVTTRQLLHGKAVIDELTIPDTKFVGRAPQGYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK3</accession>
    <name>F9UTK3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine betaine/carnitine/choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642847.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3324"/>
    <dbReference type="EnsemblBacteria" id="CCC80321">
        <property type="protein sequence ID" value="CCC80321"/>
        <property type="gene ID" value="lp_3324"/>
    </dbReference>
    <dbReference type="GeneID" id="57026585"/>
    <dbReference type="KEGG" id="lpl:lp_3324"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2772"/>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010118_6_0_9"/>
    <dbReference type="OMA" id="AWAPFTG"/>
    <dbReference type="PhylomeDB" id="F9UTK3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2812-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="555" mass="61039" checksum="83D7EF8A9F16CD0C" modified="2011-10-19" version="1">MLSSRFIILKSKNIDWWVYLPTIGLFAAASVVLLMGGHSLETSLSGILNWLTNNMSWLYMSVYVITFIFFIYLGFSKLGKTKLGDPDDKPEFSTYHWGSMVYATGIDASILMLSMVDPLRYLQSPSFGVKPFSTSAYNYAHMLGQFNWGPMAWMMFAPATIAIAYAMYVKHIKVQRLSAAISVLQGPGKGKQIARNTIDFLVIIGIMGGVGTSVGMEIPVISKVLSAVTGIADTMTLKLGLFALLFVIFAMAVFNGLKKGIGRLSAAHVWLAIGFLIVVLIVGPTLYILNSETNSIGLFVNKFITLSTNTAPNGHATAMQRQTIFYWGWWLSFMPVMGLFIARISRGRTIRQVLGGMLLWGSLGCVSFYAILGGYALYLQRMGIVNLVHILNTQGQAAVIAAVLSTLPLKMIMLALYCLSCFIFLATTVSSFAFITSSFTSKKLAAGEQPSRFNRMSWVVIFLVFSLGLVTVGGFESIQSICAMSGFPLTIVALVLLYSIHHDLTTDPVKEAAKANAKAAELARRKRLARDVEITTKTDYARERRTARKRETEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM5</accession>
    <name>F9UTM5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp3</name>
        <name evidence="4" type="ordered locus">lp_3352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890857.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3352"/>
    <dbReference type="EnsemblBacteria" id="CCC80343">
        <property type="protein sequence ID" value="CCC80343"/>
        <property type="gene ID" value="lp_3352"/>
    </dbReference>
    <dbReference type="GeneID" id="57026606"/>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.2795"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_1_9"/>
    <dbReference type="OMA" id="LILEMAV"/>
    <dbReference type="PhylomeDB" id="F9UTM5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2832-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16673" checksum="5E6C4EF37606E615" modified="2011-12-14" version="1">MANDMMNWHNDLFDRLNDWTKMDDLVNGFGRTFLNAGSHGSVLKTDIKENDDQYTMKVDIPGIDKQNIALKYRDGTLSIAVKRDSISDESDKDGNIIASERQTGRFGRQYSLPDVDVDKIEARYENGVLQLTLPKKAAADTHHIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU30</accession>
    <name>F9UU30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888464.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0445"/>
    <dbReference type="EnsemblBacteria" id="CCC77950">
        <property type="protein sequence ID" value="CCC77950"/>
        <property type="gene ID" value="lp_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0445"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.365"/>
    <dbReference type="eggNOG" id="ENOG502Z9IV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096751_0_0_9"/>
    <dbReference type="OMA" id="ATKDIDM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-371-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="30591" checksum="44CAD48D878574EE" modified="2011-10-19" version="1">MLFHKFFDFFEGYEDCYVIIGGNAAAIWLAQDHQDFRATQDYDMVVIFENSQLGFSQKFDDFIEKYGYLCVEIGGDVNKKKVYYRFALDPALAVTGVPQQIELFSKIPLRYELRLPTETMPLHFATGPSLSAIVLNDDYYSLLKQCQQKIGHVSILSVPGLIYFKAKAHLDIRQRLANGDKLRHRANKNKHYKDVCRLCDLIIENQTFDSKVVPRTCQNDLKSFIQLVEAEPEQIFKKRFKSDPDFDLNRDEVVRVLRSLLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU36</accession>
    <name>F9UU36_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
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                <person name="Nierop Groot M.N."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="129" mass="14452" checksum="ECA24FF840CB41BA" modified="2011-10-19" version="1">MQPDIICANGVFCADGKVLLTRESKNTAYYFPGGKVGVGETLTQTLQRELKEELSLVVSPDRFKWAFTHRGAAYNQPGKIVELNCFLVAGSGALKVDSEVYDYKWCRPDDSRIAEVVREALARYSWVVE</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0463"/>
    <dbReference type="EnsemblBacteria" id="CCC77965">
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        <property type="gene ID" value="lp_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0463"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.382"/>
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        <ligand>
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    </evidence>
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    </evidence>
    <sequence length="232" mass="26057" checksum="41F77A1830127F51" modified="2011-10-19" version="1">MTEPLIAVQHLGIGFPNNQVFKDLNFNIEQGDFLTVIGENGVGKTTLIRALLGMLKPTAGQIKYYPNKKAIKIGYVPQFRNLDQEYPLTIEDFVGLNLKGWQPWLSRAEHRQVATALAVTNLKKLRQRPLGMASGGEKQRAYLAQAIVQQPQLLILDESTASLDNEMKYELLDLVQNLNQTSNITVFFVTHDLPLAKQYAKHYLALKPGHQQFGNIADMSIEQLKEATNVNV</sequence>
</entry>
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    <accession>F9UU52</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643513.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890868.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="gene ID" value="lp_3367"/>
    </dbReference>
    <dbReference type="GeneID" id="57026617"/>
    <dbReference type="KEGG" id="lpl:lp_3367"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2807"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="138" mass="16756" checksum="55A0E8EB394B8975" modified="2011-10-19" version="1">MKPNSKLLQRLRSWMRGRYGQNDTLNRFLNNLALLLIVISFFIRTGWLLLIAVILIGISYWRLFSKKIYQQVAINRGFQRFWSPIVRPFSRLKYQVKQHWQYRVFRCSQCHQRIRIPRHHGRVRITCPQCGHQFEAKV</sequence>
</entry>
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    <accession>F9UU81</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890897.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3402"/>
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    <dbReference type="EnsemblBacteria" id="CCC80383">
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        <property type="gene ID" value="lp_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3402"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2833"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_0_3_9"/>
    <dbReference type="OMA" id="HAFTEPI"/>
    <dbReference type="PhylomeDB" id="F9UU81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2870-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="33169" checksum="5A9345EE006F1278" modified="2011-10-19" version="1">MLLILAILPIVVTVGLGVFAGLRHQFAPTTSDILIQLVMHYALPLSLFGGILSLKRATIIQNSSVALWLALGMLGGMVIVIVSQCCFHQQLETGTLRALVIASPSIPFMGVSVLLVVFGKISVLLVALGGLYMNLVQVPVSVLLLTLAGGSTPEQRWRAGWQKLCRASRQPVVWAPISAFLLNLAGLRLPSAWLTNFTELGQAAGGVALFALGLLLTTRPWRLTRMVVLNVLLKNLGLPVLIWGIMASLGVSLSNQQLVVLTLAIPTATIATMLAVQNHLAPDEYVATQMLSTVIAPLTMGFLMWGLQLV</sequence>
</entry>
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        </submittedName>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890911.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3416"/>
    <dbReference type="EnsemblBacteria" id="CCC80397">
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3416"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2846"/>
    <dbReference type="eggNOG" id="COG1846">
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_MARR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="167" mass="19732" checksum="C6B49509896E8EFB" modified="2011-10-19" version="1">MNEDMEFFNRFSHMYLHGFKNLSDMFAEPATEHGITLDEFYILYDIAEAKGKIRLMDIAESHGVTRSAISRLIGRLLRKDYLYQEAEDHDRRNKVLKLTPEGARIEHEVFTELIQRNREWRQSFSLAKQYQTLNLVEEFMDKFVNEDASKQTKKATYADTDLKRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE9</accession>
    <name>F9UUE9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacL</name>
        <name evidence="10" type="ordered locus">lp_3483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3483"/>
    <dbReference type="EnsemblBacteria" id="CCC80451">
        <property type="protein sequence ID" value="CCC80451"/>
        <property type="gene ID" value="lp_3483"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG3250">
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    </dbReference>
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    <dbReference type="OMA" id="QEVKYYY"/>
    <dbReference type="PhylomeDB" id="F9UUE9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2939-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="229"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="331"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="626" mass="72180" checksum="D66FADB63DD4BCAE" modified="2011-10-19" version="1">MQANLQWLDDPEVFRVNQLPAHSDHHYYHDTAEFKTGSRFIKSLNGAWRFNFAKTPAERPVDFYQPDFDATDFDTIQVPGHIELAGYGQIQYINTLYPWEGKIYRRPPYTLNQDQLTPGLFSDAADNTVGSYLKTFDLDDAFKGQRIIIQFQGVEEALYVWLNGHFIGYAEDSFTPSEFDLTPYIQDQGNVLAVRVYKRSTAAFIEDQDMFRFSGIFRDVNILAEPASHITDLDIRPVPNANLKSGELNITTKVTGEPATLALTVKDHDGRVLTSQTQTGSGSVTFDTMLFDQLHLWSPQTPYLYQLTIEVYDADRQLLEVIPYQFGFRTVELRDDKVIYVNNKRLVINGVNRHEWNAHTGRVISMDDMRADIQTMLANNINADRTCHYPDQLPWYQLCDEAGIYLMAENNLESHGSWQKMGAIEPSYNVPGDNPHWLAAVIDRARSNYEWFKNHPSIIFWSLGNESYAGEDIAAMQAFYKEHDDSRLVHYEGVVHTPELKDRISDVESRMYEKPQNIVAYLEDNPTKPFLDCEYMHDMGNSLGGMQSYNDLIDKYPMYQGGFIWDFIDQALFVHDPITDQDVLRYGGDFDERHSDYEFSGDGLMFADRTPKPAMQEVKYYYGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF0</accession>
    <name>F9UUF0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lacM</name>
        <name evidence="6" type="ordered locus">lp_3484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3484"/>
    <dbReference type="EnsemblBacteria" id="CCC80452">
        <property type="protein sequence ID" value="CCC80452"/>
        <property type="gene ID" value="lp_3484"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3484"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2900"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075527_0_0_9"/>
    <dbReference type="OMA" id="WLGADMF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2940-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="5">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="35223" checksum="103EDABF9DDDDE37" modified="2011-10-19" version="1">MAYTNNQLHVIYGDGSLGLQGANFHYLFSYERGGLESLVVNDKEWLYRTPTPIFWRATTDNDHGSGFSVKSAQWYAADKFSTCQDIELTVDDQPVTPLPIAPLNNKYTDHEIATKVSLAYHFVTTTVPSTIVTVTYTVTADGQINIATHYSGQSDLPELPAFGLRFIIPTTATGFDYTGLSGETYPDRLAGATHGRFHVDSLPVTPYLVPQECGMHMQTEQVTVTRSTTQNNADHDNTPFSLTFSQADAPFAFSCLPYTAAELENATHMEELPLARRTVLSIYGAVRGVGGIDSWGTDVESPYHIPADQDIDFSFNIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG0</accession>
    <name>F9UUG0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="3">SDH</shortName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aroD2</name>
        <name evidence="3" type="synonym">aroE</name>
        <name evidence="6" type="ordered locus">lp_3494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3494"/>
    <dbReference type="EnsemblBacteria" id="CCC80462">
        <property type="protein sequence ID" value="CCC80462"/>
        <property type="gene ID" value="lp_3494"/>
    </dbReference>
    <dbReference type="GeneID" id="57026708"/>
    <dbReference type="KEGG" id="lpl:lp_3494"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2910"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_4_9"/>
    <dbReference type="OMA" id="SIFARND"/>
    <dbReference type="PhylomeDB" id="F9UUG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2950-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="3">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="32361" checksum="B884EF72B03719C7" modified="2011-10-19" version="1">MAERIDGHTLLIGLMAYPIRHSMSPTMHNNAFAKLGLNYAYLAFEVTNETLPSAIESIRTLDMRGSNISMPNKQKVIPLLDKLDPAAKMVGAVNTIVNDDGVLTGYTTDGIGFMKALADEGLDIREHKMTLAGAGGAGTAIAVQAALDGVKEISIFNMHDATWANAERNVKLINEQTDCHATLHSLEDRDDFKREIQSSYIYTDSTGVGMKPLEDKTLVDDPSWFSSDQIVFDTVYAPRTTKLMKVARQAGLKHVYNGLGMMLEQGAAAFKLWTGEDMPVDYIHQILFSDDQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ6</accession>
    <name>F9UUJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase (Malto-oligosaccharides)</fullName>
            <ecNumber evidence="6">3.2.1.10</ecNumber>
            <ecNumber evidence="6">3.2.1.2</ecNumber>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">agl</name>
        <name evidence="6" type="ordered locus">lp_3534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="6"/>
    <dbReference type="EC" id="3.2.1.2" evidence="6"/>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102209.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891012.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUJ6"/>
    <dbReference type="STRING" id="220668.lp_3534"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80498">
        <property type="protein sequence ID" value="CCC80498"/>
        <property type="gene ID" value="lp_3534"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3534"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2946"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_9"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="PhylomeDB" id="F9UUJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2986-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102229">
        <property type="term" value="F:amylopectin maltohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016161">
        <property type="term" value="F:beta-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4968" evidence="4">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="688"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="766" mass="87320" checksum="94130850F6D58616" modified="2011-10-19" version="1">MSALPSYTQNGQTITFAFAQPLQLTIVTPEIIRVFINRGEQGESYAIEGHKIQATDFTIESAGDHYIIRTSALTIHLDSERHLDTFDKDGNALITDYRGERIHLKGVDKVHERLVEAEGHSVTKAPTKSDQGYYEIIKSLAPDEYLYGLGDKTGYLNKRGFAYDNWNVDNPAPQLEILPNIYKSIPVMLGLKNGHPYGIFFDNTYQSHLDMGKESNHYYFYSAVQGNLDYYIIGGTTLKDIVTNYTYLTGRTPLPQKWTLGYQQSRWGYSASQEEVQAIADNLAKYDLPCDAIHFDVDYMDGYRVFTWDKDKYQGNPKKFITKLNQQGLKVIPIIDPGVKQDSDYHIYAEGLKKGYFVKSADGDVYINKVWPGNAAFPDFGRPEVRQWWANNGKFLTDLGVAGIWIDMNEPATFEGPIPDDVVFNDQDTPSTHKKMHNVYGHNMAKATYAGLKEQTGNRPFVITRAAYAGTQKYSTVWTGDNRSMWPHIQMMIPQLCNLGLSGFSFTGTDIGGFASDTTSELLTRWIEGAIFSPLLRNHAALGTRQQEPWAFGEPTLNIYRKYLKLRYRLIPYLYDLFAKETKTGLPIMRPVVLNYDQDPRVRDLNDEYMVGDDILVAPVVQKSQFKRLVYLPAGNWVDFWNGAEYAGNQDIVVDTPLDKLPLFVKQNTILPWGPAVSHISDEPLKAMTFRVFGTQGTYQHYQDNGRDFKYQSGEWNNYTITVDHNKVNVQLTHHGYQPVYQQITVELSDHVVKLTYDNDSSCYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE1</accession>
    <name>Q6LWE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf36</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222042.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133750.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723586"/>
    <dbReference type="EnsemblBacteria" id="CAG17867">
        <property type="protein sequence ID" value="CAG17867"/>
        <property type="gene ID" value="CAG17867"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17867"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3114"/>
    <dbReference type="eggNOG" id="ENOG50309KE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100132_0_0_9"/>
    <dbReference type="OMA" id="ESWQGIN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3167-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="204" mass="23648" checksum="20F8457E1D99FF2B" modified="2004-07-05" version="1">MKVESWQGINGKLVHDDQKAIVVDDDQALTDPKQLQAILDQDGQPIDEVRRAMIKKTVKRQLKTDPLKLSGWFNRHQDSQNAKKAEKLVSDKPTHQYKQIKNEMTFFGESFLEGFLGFYGLEVDNALGRYEHNLHVLETQELGQSEKEYYLATSQNGRVKLATDPLPSQQIAEEQLNKFYQREPEETQAEQIQLRTSEDDRKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SC3</accession>
    <accession>F9UUH4</accession>
    <name>MURQ1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate etherase 1</fullName>
            <shortName evidence="1">MurNAc-6-P etherase 1</shortName>
            <ecNumber evidence="1">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate hydrolase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate lyase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murQ1</name>
        <name type="ordered locus">lp_3508</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CCC80476" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80476.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033098929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SC3"/>
    <dbReference type="SMR" id="Q88SC3"/>
    <dbReference type="STRING" id="220668.lp_3508"/>
    <dbReference type="EnsemblBacteria" id="CCC80476">
        <property type="protein sequence ID" value="CCC80476"/>
        <property type="gene ID" value="lp_3508"/>
    </dbReference>
    <dbReference type="GeneID" id="57026721"/>
    <dbReference type="KEGG" id="lpl:lp_3508"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2924"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_9"/>
    <dbReference type="PhylomeDB" id="Q88SC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2964-MON"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000249631" description="N-acetylmuramic acid 6-phosphate etherase 1">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="300" mass="31278" checksum="BC05DBB5E3441918" modified="2006-09-19" version="2">MKSDINQLTTEGRNPASNDLDEMSILAIAQLMNQEDAKVSQSITPELPQIAAAIALIVTAFKANGRLIYMGAGTSGRLGVLDAAECVPTFGTEPEMVQGLIAGGAQAMTVAVEGAEDNPNLGAQDLKDLALTANDAVVGLAASGRTPYVIGALDYAQKIGAATISLACNNQALISQHARVAIEVTPGPEVLAGSTRLKAGTAEKMVLNMLSTISMVKIGKVYHNLMVDVKPTNEKLVIRAKHMIELATGVSADEASELFAAAHQNVKTAIVMDLAGVSVSDAEQRLQRAHGVVRDALALQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SE8</accession>
    <accession>F9UUE8</accession>
    <name>GAL1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactokinase</fullName>
            <ecNumber evidence="1">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">galK</name>
        <name type="ordered locus">lp_3482</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890964.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SE8"/>
    <dbReference type="SMR" id="Q88SE8"/>
    <dbReference type="STRING" id="220668.lp_3482"/>
    <dbReference type="EnsemblBacteria" id="CCC80450">
        <property type="protein sequence ID" value="CCC80450"/>
        <property type="gene ID" value="lp_3482"/>
    </dbReference>
    <dbReference type="GeneID" id="57026696"/>
    <dbReference type="KEGG" id="lpl:lp_3482"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2898"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_9"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="PhylomeDB" id="Q88SE8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2938-MON"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0299">Galactose metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184617" description="Galactokinase">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <sequence length="387" mass="42646" checksum="E6DCB3FB8EEA0D66" modified="2003-06-01" version="1">MNTSDLKQEFTEAFDTKPERVFFSPGRINLIGEHTDYNGGHVFPCAITIGTYGVYAPRTDTTVRMYSANIPDAGIVTFDVNDLSYDKAAGWTNYPKGMMDEIAKTGVKFDHGFDFYVHGNMPDGAGLSSSASIELLTGIMLNTGFNLGISQLDLVKIGQKCENNYVGVNSGIMDQFAVGMGKKDQAILLDTNTMDYSYAPVKLGNNVIVIMNTNKRRELADSKYNERRSECEEALRRLQTKLDIKSLGDLTNDQFDEAAYLINDETLIKRARHAVFENQRAIRATKALADDDLTTFGELVTASHVSLHFDYEVTGKELDTLAETAWKQPGVLGARMTGAGFGGCGIAIVDKDQVDAFKENVGKVYRDTIGYDADFYIAEIADGPKEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SK7</accession>
    <accession>F9UU86</accession>
    <name>UPPP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP</name>
        <name type="synonym">bacA</name>
        <name type="synonym">upk</name>
        <name type="ordered locus">lp_3407</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890902.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SK7"/>
    <dbReference type="SMR" id="Q88SK7"/>
    <dbReference type="STRING" id="220668.lp_3407"/>
    <dbReference type="EnsemblBacteria" id="CCC80388">
        <property type="protein sequence ID" value="CCC80388"/>
        <property type="gene ID" value="lp_3407"/>
    </dbReference>
    <dbReference type="GeneID" id="57026634"/>
    <dbReference type="GeneID" id="66450898"/>
    <dbReference type="KEGG" id="lpl:lp_3407"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2837"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_2_0_9"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="PhylomeDB" id="Q88SK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2875-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000151159" description="Undecaprenyl-diphosphatase">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="275" mass="30552" checksum="DCC524DD6CD57631" modified="2003-06-20" version="1">MLDIFKAVILGIVEGITEFLPISSTGHLVLVDEFIKMQQSTQFTDMFNVVIQLGAIMAVVVLYFHKLNPLSPRKDTTEKRNTWVLWSKVLLAVIPSVIVGLPLNDWMDEHLMNWAVVSATLIIYGVLFIVIENHNKRLTPRFANLQTLPYTTALFIGCFQLLSLIPGTSRSGATILGAILIGTSRYVATEFSFFMAIPTMFGASLLKLVKFFAHGGSLAGLQGAVLAVGVIVSFVVAYLSIRFLLDYIKKNDFKAFGWYRIVLGVLVIGYFTLIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88T35</accession>
    <accession>F9UT83</accession>
    <name>GPMA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2</fullName>
            <shortName evidence="1">BPG-dependent PGAM 2</shortName>
            <shortName evidence="1">PGAM 2</shortName>
            <shortName evidence="1">Phosphoglyceromutase 2</shortName>
            <shortName evidence="1">dPGM 2</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA2</name>
        <name type="synonym">pmg9</name>
        <name type="ordered locus">lp_3170</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642405.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890715.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88T35"/>
    <dbReference type="SMR" id="Q88T35"/>
    <dbReference type="STRING" id="220668.lp_3170"/>
    <dbReference type="EnsemblBacteria" id="CCC80201">
        <property type="protein sequence ID" value="CCC80201"/>
        <property type="gene ID" value="lp_3170"/>
    </dbReference>
    <dbReference type="GeneID" id="57026463"/>
    <dbReference type="GeneID" id="66450722"/>
    <dbReference type="KEGG" id="lpl:lp_3170"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2649"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_5_9"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="PhylomeDB" id="Q88T35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2689-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179887" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="230" mass="26087" checksum="48F3904EEB2E142D" modified="2003-06-01" version="1">MAKLVLIRHGQSEWNLSNQFTGWVDVDLSEKGVEEAKAAGQKVKEAGLEFDYAFTSVLTRAIKTLHYVLEESDQLWIPETKTWRLNERHYGALQGLNKKETAEKYGDDQVHIWRRSYDVLPPLLSADDEGSAVNDRRYADLDPNIVPGGENLKVTLERVMPFWEDQIAPKLLDGKNVIIAAHGNSLRALSKYIEQISDDDIMDLEMATGEPVVYDFDEKLKVLGKEKLGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU4</accession>
    <accession>F9UQR2</accession>
    <name>ATPE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpC</name>
        <name type="ordered locus">lp_2363</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641444.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU4"/>
    <dbReference type="SMR" id="Q88UU4"/>
    <dbReference type="STRING" id="220668.lp_2363"/>
    <dbReference type="EnsemblBacteria" id="CCC79551">
        <property type="protein sequence ID" value="CCC79551"/>
        <property type="gene ID" value="lp_2363"/>
    </dbReference>
    <dbReference type="GeneID" id="57025895"/>
    <dbReference type="KEGG" id="lpl:lp_2363"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1996"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_0_9"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="PhylomeDB" id="Q88UU4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2035-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000188149" description="ATP synthase epsilon chain">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <sequence length="142" mass="15698" checksum="411CA7D050036085" modified="2003-06-01" version="1">MADNAKSLTVSIVTPDGQVYENKTPMLIVRTIDGELGILPNHIPVIASLAIDEVRIKQLESDQEDDEIAVNGGFVEFSNNTATIVADSAERQNDIDVARAENARKRAETRIQNAQQKHDDAELARAQVALRRAMNRLNVARH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UZ7</accession>
    <accession>F9UQK9</accession>
    <name>MUTS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS</name>
        <name type="synonym">hexA</name>
        <name type="ordered locus">lp_2298</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101708.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890012.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UZ7"/>
    <dbReference type="SMR" id="Q88UZ7"/>
    <dbReference type="STRING" id="220668.lp_2298"/>
    <dbReference type="PRIDE" id="Q88UZ7"/>
    <dbReference type="EnsemblBacteria" id="CCC79498">
        <property type="protein sequence ID" value="CCC79498"/>
        <property type="gene ID" value="lp_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2298"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1942"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_9"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="PhylomeDB" id="Q88UZ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1982-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115105" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="607"/>
            <end position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="896" mass="99980" checksum="2B37FD1913EE2D4D" modified="2003-06-01" version="1">MPQKTKDTPMMRQYFAVKNQYPDAFLFYRLGDFYEMFFDDAIKGAQLLELTLTTRNHSAENPIPMCGVPHRAVQNYIDILVDKGYKVAICEQMEDPKLAKGMVKREVIQLVTPGTTLERGAEQAKTNNYLTALIQRDQQYGFAYADLSTGELKTSVLTTNDTLINELTSLQTKEIVVDDSVASDLRDQIKTLGILISEQNNVTPQAQLSYLTQDLTVDLEQQVVERLLMYITVTQKRSLAHLQKAIAYEPSYFLKLDHNSKYNLELMKSIRTGKKQGTLLWLLDETKTAMGGRLLKQWIDRPLIVKADIETRQNKVATLLDHYFERSNLQEELTKVYDLERLAGRVAFGSVNGRDLVQLKTSLRQIPKIRYILSELDTQVFNDEVNQLDPVEDVADLIDAAIVEDAPLSVTDGGVIKDGYNEQLDQYRDAMNNGKKWIAELEAQERATTGIKNLKIGFNRVFGYYIEVTKANLAQLPKDRYERKQTLTNAERFSTPELKSHESLILEAESHSTDLEYQLFTKVRETVKKAIQRLQTLAKAVAAIDVLQSFAVVSEDYHFVRPKLTKSHDLKIVDGRHPVVEKVMGNQSYVPNNVTMSPDETVLLITGPNMSGKSTYMRQLALTVIMAQIGCFVPAKSAQLPIFDQIFTRIGATDDLISGQSTFMVEMQEANNALQHATANSLVLFDEIGRGTATYDGMALAQAIIEFVHNHIHAKTLFSTHYHELTALDQELSGLRNVHVGATEQDGELVFLHKVEPGAADKSYGVHVAKLAGMPTSLLERANKILTSLENQTSTVSTTAASIAASDAANSVAPNTAASMPVEAADESQPVESETPVAEAPVAEAGDEQLSLFAEPAVTDAKGEKVLQQLKTLNLMAMTPMDVMNQLYKWQQKLGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VB2</accession>
    <accession>F9UQ94</accession>
    <name>DEF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide deformylase</fullName>
            <shortName evidence="1">PDF</shortName>
            <ecNumber evidence="1">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">def</name>
        <name type="synonym">def1</name>
        <name type="ordered locus">lp_2155</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889897.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VB2"/>
    <dbReference type="SMR" id="Q88VB2"/>
    <dbReference type="STRING" id="220668.lp_2155"/>
    <dbReference type="EnsemblBacteria" id="CCC79383">
        <property type="protein sequence ID" value="CCC79383"/>
        <property type="gene ID" value="lp_2155"/>
    </dbReference>
    <dbReference type="GeneID" id="57025689"/>
    <dbReference type="GeneID" id="66449918"/>
    <dbReference type="KEGG" id="lpl:lp_2155"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1824"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_0_9"/>
    <dbReference type="OMA" id="DMMEYLV"/>
    <dbReference type="PhylomeDB" id="Q88VB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1844-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082793" description="Peptide deformylase">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <sequence length="186" mass="20855" checksum="E080FF56D7723576" modified="2003-06-01" version="1">MIKMRDIIREGNHTLRAEAKQVKFPLSEADQKLANDMMEYLENSQDPELAKKYGLRAGVGLAAPQVDVSEQMAAVLVPSENEDDEPVFKDVIINPVIISHSVQPGALTEGEGCLSVDRDIAGYVIRHDRITLRYYNMAGEEKKIRLKNYPAIVCQHEIDHLHGILFYDHINGDNPFAADDDLVLIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VR8</accession>
    <accession>F9UPT4</accession>
    <name>YBEY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">lp_1969</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640681.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889737.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VR8"/>
    <dbReference type="SMR" id="Q88VR8"/>
    <dbReference type="STRING" id="220668.lp_1969"/>
    <dbReference type="PRIDE" id="Q88VR8"/>
    <dbReference type="EnsemblBacteria" id="CCC79223">
        <property type="protein sequence ID" value="CCC79223"/>
        <property type="gene ID" value="lp_1969"/>
    </dbReference>
    <dbReference type="GeneID" id="57025548"/>
    <dbReference type="KEGG" id="lpl:lp_1969"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1663"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_0_9"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="PhylomeDB" id="Q88VR8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1687-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102472" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="159" mass="18038" checksum="19B6336277B4FD49" modified="2003-06-01" version="1">MDLELYDQTTTGAQPEQLQLIRDLIDLAGQTLKLRDDTEVSVTLMNNDAIQKINEQYRGVDRPTDVISFAMHDDDEDDLIVMDPEMAAEMPLNLGDIMISVDKVSEQAAFLNHSEARELGYLVVHGFLHLNGYDHLQPADETEMFTLQRQILDAYGLEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WA8</accession>
    <accession>F9UP95</accession>
    <name>SYN2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Asparagine--tRNA ligase 2</fullName>
            <ecNumber>6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparaginyl-tRNA synthetase 2</fullName>
            <shortName>AsnRS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">asnS2</name>
        <name type="ordered locus">lp_1740</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889548.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WA8"/>
    <dbReference type="SMR" id="Q88WA8"/>
    <dbReference type="STRING" id="220668.lp_1740"/>
    <dbReference type="EnsemblBacteria" id="CCC79034">
        <property type="protein sequence ID" value="CCC79034"/>
        <property type="gene ID" value="lp_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1740"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1468"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_9"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="PhylomeDB" id="Q88WA8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1497-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176419" description="Asparagine--tRNA ligase 2">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="432" mass="49868" checksum="C2A3AAEDFD02DA67" modified="2003-06-01" version="1">MVQQINIIDAKDHVDEKVKIGAWLTNKRSSGKIAFLQLRDGSAFFQGVVVKSQVSEEVFELAKEVKQEASMWITGVIHEDSRSKFGYEIEVEDIVVVGESEEYPITPKEHGVDFLLDHRHLWLRSKRPWAIMNIRNEVIRGTYEFFNQEGFIKMDSPILTGSAPEGTTELFHTEYFDRDAYLSQSGQLYAEAGALAYGKVFTFGPTFRAEKSKTRRHLIEFWMIEPEMAFMHQEQSLEVQERYIAFLVQGVIDHCQYALDILGRDVETLKKYTKLPYPRISYDEAIELLKENDFDVDWGVDFGSPEETFLADHFDQPVFVLNYPKAIKPFYMKPHPTRDDVVICADLLAPEGYGEIIGGSERATDYNYLLDQIKQAGLNPDDYAWYLDLRKYGSVPHAGFGLGLERFLTWITAEDHVRETIPFPRLLNRIYP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WI0</accession>
    <accession>F9UP23</accession>
    <name>TRPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpB</name>
        <name type="ordered locus">lp_1657</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101492.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889476.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WI0"/>
    <dbReference type="SMR" id="Q88WI0"/>
    <dbReference type="STRING" id="220668.lp_1657"/>
    <dbReference type="EnsemblBacteria" id="CCC78962">
        <property type="protein sequence ID" value="CCC78962"/>
        <property type="gene ID" value="lp_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1657"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1398"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_9"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="PhylomeDB" id="Q88WI0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1425-MON"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000098960" description="Tryptophan synthase beta chain">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <sequence length="399" mass="43172" checksum="373478CE53BD2227" modified="2003-06-01" version="1">MIKNQSQAGRYGDFGGQYVPETLMTELQRLDRAFQHYRQDAHFQEELTDLLNNYANRPSLLYHAQRLSDQLGGAQIYFKREDLNHTGAHKINNVLGQALLAKKMGKKRLIAETGAGQHGVATATIAALFGMECDVFMGKKDTNRQALNVYRMQLLGAKVHPVTTGSMVLKDAINAALQEWTRRCDDTAYIMGSATGPHPFPMMVHEFQSVISVEARQQILDQTGHLPDAVVACVGGGSNAIGSFAAFLDDTSVELIGCEAAGKGVQTPLTAATIERGRTGIFHGMKSLFLQDKAGQIAPVYSISAGLDYPGVGPEHAYLAASGRAQYVGINDDQAVQAFELIAKVEGVICAIESAHAVAYVQQLAPTMRRDQTIICTLSGRGDKDVAAIAKYRGVTIDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY2</accession>
    <accession>F9UMK9</accession>
    <name>RS19_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">lp_1038</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638064.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY2"/>
    <dbReference type="SMR" id="Q88XY2"/>
    <dbReference type="STRING" id="220668.lp_1038"/>
    <dbReference type="EnsemblBacteria" id="CCC78448">
        <property type="protein sequence ID" value="CCC78448"/>
        <property type="gene ID" value="lp_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="49393321"/>
    <dbReference type="GeneID" id="57024695"/>
    <dbReference type="GeneID" id="66448951"/>
    <dbReference type="KEGG" id="lpl:lp_1038"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.875"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_9"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="PhylomeDB" id="Q88XY2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-891-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129838" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="91" mass="10291" checksum="7E46F75592CBDB13" modified="2003-06-01" version="1">MGRSLKKGPFADAHLLKKIDAQSDSDKKSVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQDDMVGHKLGEFVPTRTFHGHGTDDKKTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YI7</accession>
    <accession>F9ULZ7</accession>
    <name>UVRA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein A</fullName>
            <shortName evidence="1">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrA</name>
        <name type="ordered locus">lp_0773</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YI7"/>
    <dbReference type="SMR" id="Q88YI7"/>
    <dbReference type="STRING" id="220668.lp_0773"/>
    <dbReference type="EnsemblBacteria" id="CCC78236">
        <property type="protein sequence ID" value="CCC78236"/>
        <property type="gene ID" value="lp_0773"/>
    </dbReference>
    <dbReference type="GeneID" id="57024477"/>
    <dbReference type="KEGG" id="lpl:lp_0773"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.653"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_9"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="PhylomeDB" id="Q88YI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-671-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000093057" description="UvrABC system protein A">
        <location>
            <begin position="1"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="309"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="607"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="639"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <sequence length="951" mass="104985" checksum="E7C3A91420CBB1DD" modified="2003-06-01" version="1">MANDKIVIHGARAHNLKDIDVTIPRDKLVVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMQKPDVDSIDGLSPAISIDQKTTSKNPRSTVGTVTEINDYLRLLWARVGEPICPNDGTPIASQTVEQMVDRIQKLPERTKLQILSPIVRQKKGEHKKIFEKIKREGFVRVRVDGDIHDISETFELNKNQQHTIEIVIDRIVVKSGDRSRLFDSFEAALRLSGGYAIADVIGGEPIMFSEHYACPICGFTVGELEPRLFSFNAPQGACPDCEGLGIKLEVDEDLVVPDKSLTLAEGALAPWNPISSQYYPEMLKQACEQLEIPMDVPYEDLSKADQQTVLYGSNGKTFHFHYQNDFGGVRDVDAVFEGVINNVDRRYHETNSDFTRDVMRKYMTELTCQTCHGFRLNRKALSVKVGGEHIGMVSDLAIGKELDFFNELSLSEQSLVIAKPILKEIRDRLSFLQNVGLAYLTLSRSARTLSGGEAQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIGSLKKMRDLGNTLIVVEHDEDTMRAADYIVDIGPGAGENGGEVMAAGTPKQVARSRKSLTGQYLSGKRFIPLPETRRPGNGKKIRITGAAENNLKQIDVDFPLGEFVVVTGVSGSGKSTLVNDVLKRVLAQKLNRNSEKPGKYKSVSGIKNIERLVNIDQSPIGRTPRSNPATYTGVFDNIRDLFAQTNEAKLRGYKKGRFSFNTKGGRCEACHGDGILKIEMNFLPDVFVPCEVCHGKQYNSETLEVEYKGKNIADVLQMTASEAVKFFEPIPKIRRKLQTLVDVGLGYVKLGQPATTLSGGEAQRMKLASELHKQQSGKNFYILDEPTTGLHSEDIRRLIGVLDRLVDAGNTVLIIEHNLDVVKSADYLIDLGPEGGDGGGTIVATGTPEQVAEVAESYTGQYLKPVLERDRAREATAPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YW7</accession>
    <accession>F9UL87</accession>
    <name>RL7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">lp_0622</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637775.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YW7"/>
    <dbReference type="SMR" id="Q88YW7"/>
    <dbReference type="STRING" id="220668.lp_0622"/>
    <dbReference type="EnsemblBacteria" id="CCC78102">
        <property type="protein sequence ID" value="CCC78102"/>
        <property type="gene ID" value="lp_0622"/>
    </dbReference>
    <dbReference type="GeneID" id="49393023"/>
    <dbReference type="GeneID" id="57024397"/>
    <dbReference type="GeneID" id="66448664"/>
    <dbReference type="KEGG" id="lpl:lp_0622"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.522"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_9"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="PhylomeDB" id="Q88YW7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-533-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243438" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="122" mass="12592" checksum="DBEF7E30B1E4BAFB" modified="2003-06-01" version="1">MAFDKDAIIDSLKEASISDLNDLVKAIEEEFDVSASAPVAVAGAAGGDAAAAKDSYDVELTESGDQKVKAIKAVRDITGLGLKDAKGLVDNVPSIIKEGVSEDEANDMKAKLEEVGGVVTLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z93</accession>
    <accession>F9UU41</accession>
    <name>RSMA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">lp_0458</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101015.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z93"/>
    <dbReference type="SMR" id="Q88Z93"/>
    <dbReference type="STRING" id="220668.lp_0458"/>
    <dbReference type="EnsemblBacteria" id="CCC77961">
        <property type="protein sequence ID" value="CCC77961"/>
        <property type="gene ID" value="lp_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0458"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.378"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_0_9"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="PhylomeDB" id="Q88Z93"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-382-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101546" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <sequence length="296" mass="32705" checksum="FFB972DDF9159A9A" modified="2003-06-01" version="1">MMSRDLDIANPARTRAIMHTYGLQVKKSLGQNFLTDQNVLHNIVATADIGTNDNVIEIGPGIGALTEYLARAAHHVLAFEIDDRLLPILDETLADYDNVTVVNQDILKADLAAMISEHLDNERPLKLVANLPYYITTPILMNILAGDVAFENIVVMMQKEVADRLAAEPGTKAYGALTIAVQYRMAAEMAMVVPRTVFVPSPNVDSAIVKLTALPLRTHVPFDEAAFFKVVKAGFAHRRKNLWNNLQSLFGKQPETKTAIQQALDIATIDPKIRAERLTVDEFITLTDALHQADLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VL04</accession>
    <accession>F9UNX9</accession>
    <accession>Q7AKU2</accession>
    <name>ARGR2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argR2</name>
        <name type="ordered locus">lp_1604</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="J. Bacteriol." volume="186" first="6059" last="6069">
            <title>Two arginine repressors regulate arginine biosynthesis in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Nicoloff H."/>
                <person name="Arsene-Ploetze F."/>
                <person name="Malandain C."/>
                <person name="Kleerebezem M."/>
                <person name="Bringel F."/>
            </authorList>
            <dbReference type="PubMed" id="15342575"/>
            <dbReference type="DOI" id="10.1128/JB.186.18.6059-6069.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="AF451891">
        <property type="protein sequence ID" value="AAL48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889432.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8VL04"/>
    <dbReference type="SMR" id="Q8VL04"/>
    <dbReference type="STRING" id="220668.lp_1604"/>
    <dbReference type="EnsemblBacteria" id="CCC78918">
        <property type="protein sequence ID" value="CCC78918"/>
        <property type="gene ID" value="lp_1604"/>
    </dbReference>
    <dbReference type="GeneID" id="57025188"/>
    <dbReference type="GeneID" id="66449488"/>
    <dbReference type="KEGG" id="lpl:lp_1604"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1353"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097103_3_0_9"/>
    <dbReference type="OMA" id="IMGTICG"/>
    <dbReference type="PhylomeDB" id="Q8VL04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1380-MON"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000205096" description="Arginine repressor">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <sequence length="152" mass="17452" checksum="A5CEA089716ED18D" modified="2002-03-01" version="1">MKKQERQRYIKRLLSSNEIERQEDFVKLLRAEDIDVTQATISRDIKDMQLVKVPSATGGYHYSMPVQKQMDTEKKLKRTLKDAYVSYATQDKFVLIKVLPGNGPALATLIEAMHYDEIFGTLGDDAHVLIICKSLAMTLELQQKIQRLLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY3</accession>
    <name>F9UKY3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine dehydratase</fullName>
            <ecNumber evidence="8">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhB</name>
        <name evidence="10" type="ordered locus">lp_0505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0505"/>
    <dbReference type="EnsemblBacteria" id="CCC77998">
        <property type="protein sequence ID" value="CCC77998"/>
        <property type="gene ID" value="lp_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0505"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.415"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086592_0_1_9"/>
    <dbReference type="OMA" id="RYYESFA"/>
    <dbReference type="PhylomeDB" id="F9UKY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-419-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="9">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="23789" checksum="03DE8DEA09BC2067" modified="2011-10-19" version="1">MTVNYKSVFDIIGPIMIGPSSSHTAGACAIGRAANSIFQEKPTDIVIHYYESFAQTHKGHGTDYAIISGILGFDPDDSRVPYAIGLARDQGINITFIEEPGDSPINHPNTAIIDLKNDDKQVTVAGCSIGGGTIEIREIKMDGFDVKPKGPLPILLVQGGENDHQHVTKQLADLTKVNDQQQYKTARGNLYEYDLDRRLKQDEIKKLAQGHANLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ1</accession>
    <name>F9UKZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sortase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srtA</name>
        <name evidence="5" type="ordered locus">lp_0514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888520.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UKZ1"/>
    <dbReference type="STRING" id="220668.lp_0514"/>
    <dbReference type="MEROPS" id="C60.006"/>
    <dbReference type="EnsemblBacteria" id="CCC78006">
        <property type="protein sequence ID" value="CCC78006"/>
        <property type="gene ID" value="lp_0514"/>
    </dbReference>
    <dbReference type="GeneID" id="57024287"/>
    <dbReference type="GeneID" id="66448562"/>
    <dbReference type="KEGG" id="lpl:lp_0514"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.423"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045680_4_2_9"/>
    <dbReference type="OMA" id="MRADQKM"/>
    <dbReference type="PhylomeDB" id="F9UKZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-427-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06165">
        <property type="entry name" value="Sortase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042007">
        <property type="entry name" value="Sortase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="234" mass="25974" checksum="920272EB5EE40540" modified="2011-10-19" version="1">MKSKQHPGLKWLGRGVFVLLVLVSLALIFNEQIKSWLVSSYSPTVTAKTVKQNTKKKSDFNFSKVKSLDFQTVAKARMNKNAINVIGSIAIPSVDLYLPIGNGVSNETLALAAGTMKANQKMGQGNYALAGHHMIKHGALFSPLYYKSKVGQMIYVSDAKKIYAYKTSQRTFIKATDVQVIDDVPGQKLITLITCDKTGAGRLMIRGKYEQQWSFKSAPTQVQKAFTSHFNNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL30</accession>
    <name>F9UL30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Di-and tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888559.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0558"/>
    <dbReference type="EnsemblBacteria" id="CCC78045">
        <property type="protein sequence ID" value="CCC78045"/>
        <property type="gene ID" value="lp_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0558"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.463"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063025_0_0_9"/>
    <dbReference type="OMA" id="INWATIG"/>
    <dbReference type="PhylomeDB" id="F9UL30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-475-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="368" mass="40350" checksum="34546A6FD18CA751" modified="2011-10-19" version="1">MVTVVRRTLHDKIFIIALICAGLSLFIGTPQLTAINWATIGTLFALMISVQLLRAMHLLDTLRDWLLVKSHDTRQMCQLFILLAFGGSMILTNDVAILTLIPIFLTLARRQHLAIAYPTTLIIMAANLGSAFTPIGNPQNLFLVTFYHVNLFTFFKLSTPLMLASLALLVALSRRLPRLPLTVTPTKSTPISRSQIGLAGGLLSFIMLGIFNLVPISLVIIGTIVVGLMINRRVFQYVDYALLLTFICFFIFVSAISHNPAITHWLNQLTQTAPSVYITGLITSQVISNVPAAILLANFTPHLSALFLGVNIGGLGSLVASLANLLALKQLLPFNDEQPLHHFLIVFTALNGLGLFILGLGGWFYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL52</accession>
    <name>F9UL52_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="3">2.7.8.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">npsC</name>
        <name evidence="3" type="ordered locus">lp_0582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101064.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888581.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0582"/>
    <dbReference type="EnsemblBacteria" id="CCC78067">
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    <dbReference type="KEGG" id="lpl:lp_0582"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.485"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56214"/>
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        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="214" mass="25149" checksum="46D2CE5ACF06F1E4" modified="2011-10-19" version="1">MKQLLYYLNNQSMYSKLEKFVRAFAPERYQYAMSFYRPQDQYNALVAYTLLAILCRQPRIELVRGANDKPFFKSNQDMELSITHNSKFVAVAVSDKPIGIDGEPWQTIDASIIKQVYSENEQRELVNFSELDTVFWTAKEAVSKLKNEDFYSIPKTNYYLHHGLLKDQNDKTVNYNVFDLLEGVITVATEDVNICNFERLHNDELIRFINRFHC</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888607.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0613"/>
    <dbReference type="DNASU" id="1061597"/>
    <dbReference type="EnsemblBacteria" id="CCC78093">
        <property type="protein sequence ID" value="CCC78093"/>
        <property type="gene ID" value="lp_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="57024388"/>
    <dbReference type="KEGG" id="lpl:lp_0613"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.513"/>
    <dbReference type="eggNOG" id="COG3688">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_101326_2_0_9"/>
    <dbReference type="OMA" id="VFDAHQV"/>
    <dbReference type="PhylomeDB" id="F9UL78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-524-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="181" mass="20982" checksum="E31A551CD64372AC" modified="2011-10-19" version="1">MKQQLLIVDAYNMIGNWPELNHLKQTDRLPQARDELISMLTEYKKITGLNISLVFDAMYVPGNSKSYRQADLEIIWTSKDQTADSYIEKYAGEKQSRVLQVTVATSDQAEQWVIFSEGALRVPALELRHRVKTALKDVRHTAVRTQDLGAVRKSPWNDDQLSALDQYRQQLERNHVKHHHK</sequence>
</entry>
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    <accession>F9UL89</accession>
    <name>F9UL89_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 2, mitogenic factor, cell surface lipoprotein</fullName>
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        <name evidence="4" type="ordered locus">lp_0625</name>
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    <organism evidence="4 5">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888618.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0625"/>
    <dbReference type="EnsemblBacteria" id="CCC78104">
        <property type="protein sequence ID" value="CCC78104"/>
        <property type="gene ID" value="lp_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0625"/>
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    <dbReference type="eggNOG" id="ENOG5032V8J">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_052489_0_0_9"/>
    <dbReference type="OMA" id="SRGNQYA"/>
    <dbReference type="PhylomeDB" id="F9UL89"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-536-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
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    <dbReference type="InterPro" id="IPR044927">
        <property type="entry name" value="Endonuclea_NS_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13930">
        <property type="entry name" value="Endonuclea_NS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394246" evidence="2">
        <location>
            <begin position="28"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclea_NS_2" evidence="3">
        <location>
            <begin position="107"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="68"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13930"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78104.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="387" mass="41807" checksum="975475F07B210439" modified="2011-10-19" version="1">MKKRLTIGAVLLASLALASCGNSTNKSSELSSNSSSLVAAKRKKATSLSESKVKASSESSSTAKTATNNSTQVLTKLVSYTDKESAGPTQNYYWDNGKAKLTNFDSMKAGKYAFSADNQGRSSVAKAMLTYAEYQASKGSRQGTPLDPPSWPSTNPKVAIHYGLTDRVYHGFLYNRSHSIADSLLGSGSYTSEYNFTTGTRPQNVGANQEGGMRYAEELVENYWNTHSNSKNTVSYETTPLYKGNERIPRGSLVDIKSSDNQLNKEVVVINSVEGIKINYNNGSNDAKAYQSSSRSESSKKYVSEAPKKHSETSTTNSSSSVSTKQNSAYTTNGSWTVAASGMVFVSNSNKYYSQVTNPGNYQYISQSSAQADGAQQASRGNQYARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL99</accession>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="60" mass="6904" checksum="412320FA5587DDF4" modified="2011-10-19" version="1">MQAIKNHKRELVDSIIELLPAVSPSLINAKTFWMSEGELQELIGMIHDGDRNEFYEMINS</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891097.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_3626"/>
    <dbReference type="EnsemblBacteria" id="CCC80583">
        <property type="protein sequence ID" value="CCC80583"/>
        <property type="gene ID" value="lp_3626"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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            <end position="50"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCC80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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            <fullName evidence="1">Prophage P1 protein 32</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888647.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0655"/>
    <dbReference type="EnsemblBacteria" id="CCC78133">
        <property type="protein sequence ID" value="CCC78133"/>
        <property type="gene ID" value="lp_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0655"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.548"/>
    <dbReference type="eggNOG" id="ENOG5030AWD">
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            <dbReference type="EMBL" id="CCC78133.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="55" mass="6122" checksum="744C9A993D438BB0" modified="2011-10-19" version="1">MSDTEYAKAIRMKATVANLEMNAALTTEQQAQIGQDFIADIMELSDHESKQKAAY</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ0</accession>
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        <submittedName>
            <fullName evidence="2">Prophage P1 protein 39, portal protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888653.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0662"/>
    <dbReference type="EnsemblBacteria" id="CCC78139">
        <property type="protein sequence ID" value="CCC78139"/>
        <property type="gene ID" value="lp_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0662"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.554"/>
    <dbReference type="eggNOG" id="ENOG502Z7Z6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034083_1_0_9"/>
    <dbReference type="OMA" id="DAYETNL"/>
    <dbReference type="PhylomeDB" id="F9ULQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-573-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006428">
        <property type="entry name" value="Portal_SPP1-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01538">
        <property type="entry name" value="portal_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="552" mass="62084" checksum="BA5AE0B8C1996E5F" modified="2011-10-19" version="1">MIINSIYGKRRFDREANRDYTMPVGTYTAVAEQPLELMKIVPQFINHHQNHQVSRLQTLYDYYQANNAIKKQVDSNNPYHANNRVAAAFARYMTSIRVGYLIGNPIQLKLQDDTEVDDSQAEKFQDVLNDFTSHSNADYVNQQLAKDLSITGRAYDLVYVKNGVTDLGLVRVDPEQAFVIYDDTVDHKPLVGVRYYQTGILDNQLVEHYEVYTDSQLFTFHSEGGLPQTNSPVANAVLDDTLPHFFDTVPLTEYRNNDERLGDWEPELDQLDALDKSVSMMADFQEDFNNANIVLTGKFSNMTEPKYLLDENGNKKIGQDGQPIIIEPAHPNVDPKNHMWYLEPFAASGGVGSTAKHIIQPDAKYLTKQYDAAGWSTYTNFLINEIHKYTNTPNVNDPNFASNASGVAMSYKLWGSDQERKLQETLFKRGLHARLNACVNYWQTLNQISADNWNTMIKANFMPNLPKNDDATAQLITLLNGTGKFSDETIRDMAEPITGINADTEAERIKEDAQAAQEGDSNYAQGDGGLGKIFATGEKTPVPNQNSKGADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR4</accession>
    <name>F9ULR4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 53, GDSL-like lipase/acylhydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101126.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888667.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0676"/>
    <dbReference type="DNASU" id="1061969"/>
    <dbReference type="EnsemblBacteria" id="CCC78153">
        <property type="protein sequence ID" value="CCC78153"/>
        <property type="gene ID" value="lp_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0676"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.568"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841423_0_0_9"/>
    <dbReference type="OMA" id="TEDYEKS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-587-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="133"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="330" mass="37117" checksum="4E50539B2AF3ED96" modified="2011-10-19" version="1">MSNTDKYYRDRSHITGKLDLQKLPKAIREKQYGIDVREAMAQTAEAIAGVQSTAQKFNQDTKNQVNQLDEKYTREIRAIVLGDTTSVATPPIQEPNSEASNPLSNLYETARGQVLYDFVKQSSLTKVSKIGVIGDSVAATAGGFPDILAHQYNIYVENLSVGGAKMSDYNHDAIVNQASRLQQCDVVIIQGTDDDWVHDISLGYAGDTNIKTYLGGLRETIKRVKNNNPKAKLIVVNCTRQCVDVHGKYRTEQSKNTFGLTLIDYMEAQKKYLNQQDVPYVDLMKPTSIFEPDNPAFKKTMMHDGLHPTPEAHQYIVQEIAKDYSYYYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY4</accession>
    <name>F9ULY4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galU</name>
        <name evidence="7" type="ordered locus">lp_0757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; nucleotide-sugar metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="4 5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888737.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0757"/>
    <dbReference type="EnsemblBacteria" id="CCC78223">
        <property type="protein sequence ID" value="CCC78223"/>
        <property type="gene ID" value="lp_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="57024457"/>
    <dbReference type="GeneID" id="66448725"/>
    <dbReference type="KEGG" id="lpl:lp_0757"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.638"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_9"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="PhylomeDB" id="F9ULY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-658-MON"/>
    <dbReference type="UniPathway" id="UPA00215"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="34248" checksum="D6D71C2CBD4DF3FC" modified="2011-10-19" version="1">MSKVRKAVIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQFIVDEARKSGIEDIVIVTGKSKRSIEDYYDSNPELEDNLRAKHKEEMLKLVQETTDINLYFIRQSHPRGLGDAVLTAKAFVGDEPFVVMLGDDLMEDKVPLTKQLMNSYDKTHASTLAVMKVPHEEVSKYGVINPESEKEPGLYNVNNFVEKPSPEDAPSDLAIIGRYLLTPEIFDVLENQKPGKGDEIQLTDAIDTLNKTQRVFAHEFKGTRHDVGYKFGYLKTTIEYGLTHPDVKADLRTYIKDLGAKLSKEDSAAPKTTKKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY8</accession>
    <name>F9ULY8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein, DUF421 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0762"/>
    <dbReference type="EnsemblBacteria" id="CCC78227">
        <property type="protein sequence ID" value="CCC78227"/>
        <property type="gene ID" value="lp_0762"/>
    </dbReference>
    <dbReference type="GeneID" id="57024468"/>
    <dbReference type="KEGG" id="lpl:lp_0762"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.643"/>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077149_4_0_9"/>
    <dbReference type="OMA" id="FAAEWYE"/>
    <dbReference type="PhylomeDB" id="F9ULY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-662-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="210" mass="23687" checksum="4FA5BAE35DEB83E8" modified="2011-10-19" version="1">MFSYWDVTIKLALGLLTIILQINLSGKSNLAPISALDQVQNYVLGAIVGGMIYSTSVTVLQYILVLLIWTLLVLVLRFLTHHNRYVKRLIDGQPQLLIKNGQLLVSTALKNGMSANDLMFRLRTEGITDIRYVKRAVLEQNGQLTITQVGDDAVKYPIIVDGQVNLDALETSNHDEAWLLTQLQAQHYTVSDIYLATYTNKQLLLFPYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ5</accession>
    <name>F9ULZ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent phosphohydrolase, HD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0771"/>
    <dbReference type="DNASU" id="1063744"/>
    <dbReference type="EnsemblBacteria" id="CCC78234">
        <property type="protein sequence ID" value="CCC78234"/>
        <property type="gene ID" value="lp_0771"/>
    </dbReference>
    <dbReference type="GeneID" id="57024475"/>
    <dbReference type="KEGG" id="lpl:lp_0771"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.651"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114091_0_0_9"/>
    <dbReference type="OMA" id="NQSHFFA"/>
    <dbReference type="PhylomeDB" id="F9ULZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-669-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="24484" checksum="027691E789605788" modified="2011-10-19" version="1">MGMHQYFQSLSNLETIQRAPGFFKYQNHSVAAHSFKVAEVAQFLGDVEENAGQIVDWRALYEKALNHDYNERFIGDIKTPVKYATPTLRTMLADVEHKLSQNFVQNEIPAEFQAAYSRRLSEGKDETLEGQILSVADKIDLLYESFGEIQKGNPEPVFRDIYQESLKTIVAFKKMTSVQYFLKAVLPEMLAEPFTHQDQLQALTTQILTAGPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM19</accession>
    <name>F9UM19_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease R</fullName>
            <shortName evidence="5">RNase R</shortName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnr</name>
        <name evidence="8" type="ordered locus">lp_0797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101159.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888772.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0797"/>
    <dbReference type="EnsemblBacteria" id="CCC78258">
        <property type="protein sequence ID" value="CCC78258"/>
        <property type="gene ID" value="lp_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0797"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.675"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_4_1_9"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="PhylomeDB" id="F9UM19"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-694-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="635"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="811" mass="92361" checksum="102E8695CE30F2B8" modified="2011-10-19" version="1">MSEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDHDHFKLVQETKTVEGSFHGNDKGFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPARPGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVEIKDKKLSKYQLLITDQGLHPTEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDEANRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSHYVTENSELDREAFKRGTSVYLTDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGEIVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADLVDMFDTMGDLHRILYKHRRHRGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIYRVHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRSMKQARYADQSLGHFGLAAPYYTHFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNLPNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEAVVDSVMKFGLFVELENTVEGLVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEAPKTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNNNNHNSNNNNHNSNNNNHSTNNNRRSSTDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM23</accession>
    <name>F9UM23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnQ1</name>
        <name evidence="5" type="ordered locus">lp_0803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888776.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0803"/>
    <dbReference type="EnsemblBacteria" id="CCC78262">
        <property type="protein sequence ID" value="CCC78262"/>
        <property type="gene ID" value="lp_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0803"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.679"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="PhylomeDB" id="F9UM23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-698-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="244" mass="26844" checksum="983E3E01556ED2C5" modified="2011-10-19" version="1">MAKVIVKDLHKSYGDNEVLKGLNLEVQDNEVVCMIGPSGSGKSTFLRCLNDLEVPTQGQVVISGYDLSDKETNINLVRENIGMVFQHFNLFPHLSVLQNITLAPTQLKKESQQEAEKTARDLLATVGLSDKADAMPKSLSGGQKQRVAIARALAMHPKIMLFDEPTSALDPEMVGDVLDVMKKLAADGMTMIVVTHEMGFAKEVADRVVFMADGLIQETGKPEDVFEHPQSPRLQDFLQKVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM49</accession>
    <name>F9UM49_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport protein, major facilitator family (MFS), C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0831"/>
    <dbReference type="EnsemblBacteria" id="CCC78288">
        <property type="protein sequence ID" value="CCC78288"/>
        <property type="gene ID" value="lp_0831"/>
    </dbReference>
    <dbReference type="GeneID" id="57024529"/>
    <dbReference type="KEGG" id="lpl:lp_0831"/>
    <dbReference type="HOGENOM" id="CLU_2180507_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14382" checksum="C7FFA0E755F86D28" modified="2011-10-19" version="1">MTVRQSYLIGNFGRALFMILTVVSYNQFWLFAIIYLLSFVFQGLTQVFETPMIQAMVGSDQLGKVMTCFYTLVSVTLPLGSLAFSFLADRFDLRLFLLLFALFYAGIFLLFLASHAFKKVDELQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD1</accession>
    <name>F9UMD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888884.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0932"/>
    <dbReference type="EnsemblBacteria" id="CCC78370">
        <property type="protein sequence ID" value="CCC78370"/>
        <property type="gene ID" value="lp_0932"/>
    </dbReference>
    <dbReference type="GeneID" id="57024611"/>
    <dbReference type="KEGG" id="lpl:lp_0932"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.791"/>
    <dbReference type="eggNOG" id="ENOG5032H42">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823345_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-806-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031927">
        <property type="entry name" value="DUF4767"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15983">
        <property type="entry name" value="DUF4767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388034" evidence="2">
        <location>
            <begin position="33"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4767" evidence="3">
        <location>
            <begin position="61"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="36818" checksum="9E7385263614FC12" modified="2011-10-19" version="1">MKKVWVGLLLGSLLLAGCSMLSKSSAPKTKQQATSTKVTSKQTTNQSATTSSESSSPAKATLWNTGKKAALSTFMAAWQREMGQTYVGTYDDKVPDHLGFRFPEAFSDSSLAGRIKWGSQSVDLKWSKDGEDSSAFQVVAVATGGKADAQYPITYFFCLHNRRPVVFVTQTTNGNDLIIHDTQNSALQAGFAKIITGSRPTTLTDSALNVNMSRDAKANQWPQGYQGTWYYYDKYDHKINSMTQNDTDGLKLSYVASEGQKWIHIMGAEQTAGAGNFEYVRYHYFDGRQIPVLMNASGAGAWFDNNAYPSAAAANQMRDWQYGDESKTSPAADALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH2</accession>
    <name>F9UMH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">brnE</name>
        <name evidence="2" type="ordered locus">lp_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0981"/>
    <dbReference type="EnsemblBacteria" id="CCC78411">
        <property type="protein sequence ID" value="CCC78411"/>
        <property type="gene ID" value="lp_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="57024652"/>
    <dbReference type="KEGG" id="lpl:lp_0981"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.834"/>
    <dbReference type="eggNOG" id="COG4392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157896_0_0_9"/>
    <dbReference type="OMA" id="SYIPICI"/>
    <dbReference type="PhylomeDB" id="F9UMH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-847-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="11842" checksum="C1F3A7C450067F1B" modified="2011-10-19" version="1">MSTYIFVTILLCGLVTWLSRIVPFAIIKNLSVPQWLISFLSFVPIAIMTAIFVESLLTYHAGHWPEFNLPNIYASIPAILAGVLTKSLLAVVITGIVAMAVLRLVGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMP8</accession>
    <name>F9UMP8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate / lactate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMP8"/>
    <dbReference type="EnsemblBacteria" id="CCC78487">
        <property type="protein sequence ID" value="CCC78487"/>
        <property type="gene ID" value="lp_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1082"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.916"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_0_9"/>
    <dbReference type="OMA" id="CSDYRGH"/>
    <dbReference type="PhylomeDB" id="F9UMP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-930-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="362" mass="39320" checksum="78C70BCD01F9F556" modified="2011-10-19" version="1">MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHTLEPTHQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTAGYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVSSGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEVNSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTTMFDRIRHLKHLPGTKIMIPGDREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS2</accession>
    <name>F9UMS2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101260.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889025.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1113"/>
    <dbReference type="EnsemblBacteria" id="CCC78511">
        <property type="protein sequence ID" value="CCC78511"/>
        <property type="gene ID" value="lp_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1113"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.941"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_9"/>
    <dbReference type="OMA" id="PTAHHFM"/>
    <dbReference type="PhylomeDB" id="F9UMS2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-954-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="462" mass="48770" checksum="4FD4DBABD20267F2" modified="2011-10-19" version="1">MAEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRASSGMNAAETNVQLHHHIVDSFGDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGIKLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAADQLPLFTDVKVDELLVEAGKISGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQAIGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAAIDQLGGTGAYLIFDRGIRDRVKAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADWNQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTMGGIAINPATQVLNQDERPIAGLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT3</accession>
    <name>F9UMT3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome D ubiquinol oxidase, subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ordered locus">lp_1126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641325.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1126"/>
    <dbReference type="EnsemblBacteria" id="CCC78522">
        <property type="protein sequence ID" value="CCC78522"/>
        <property type="gene ID" value="lp_1126"/>
    </dbReference>
    <dbReference type="GeneID" id="57024769"/>
    <dbReference type="GeneID" id="66449022"/>
    <dbReference type="KEGG" id="lpl:lp_1126"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.952"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_9"/>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="PhylomeDB" id="F9UMT3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-965-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="331" mass="37280" checksum="04A97A2629BB2CFC" modified="2011-10-19" version="1">MSNLQFLWFILVGVLFSGFFFLEGFDFGVGMTIKSLAQTRAERDVVIHTIGPHWDANEVWLITAGGAMFASFPMWYASLFSGFYLILLLILVALIMRGVSFEFRSRMESDAGRNFWEWAAALGSFFAAFLFGMMFTALVKGMPINANGDMTAHFTDYVNLFSIVGGVAVTLLCYLHGLNFIRLKTTGTLRERALQWAKPLYWVLFAGEVVFAILLFFNTDFFTKKPISTTILVVALVALTVLATWGVYGNHEWLSFISSGLSLIDVVVLLFNGLFPRVMVANNSAYSILIKDASNSPYTLHLMTVISLSVLPIMLIYFIWSYWVFYKRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT8</accession>
    <name>F9UMT8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heptaprenyl diphosphate synthase component II</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hepB2</name>
        <name evidence="3" type="ordered locus">lp_1134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1134"/>
    <dbReference type="EnsemblBacteria" id="CCC78527">
        <property type="protein sequence ID" value="CCC78527"/>
        <property type="gene ID" value="lp_1134"/>
    </dbReference>
    <dbReference type="GeneID" id="57024773"/>
    <dbReference type="KEGG" id="lpl:lp_1134"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.958"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_9"/>
    <dbReference type="OMA" id="LEMCACK"/>
    <dbReference type="PhylomeDB" id="F9UMT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-969-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35876" checksum="9458B33DD3D58F6C" modified="2011-10-19" version="1">MMQTIWQPESLVAKELAALKPYLATNVKIDNAAINDRVHDLLAAGGKFLRPGFFYLFSQFGPDHNTARLRAGAAAMELLHVATLIHDDVIDESPERRHVTTIHQDYGQRNAIYAGDLLFTCYFDQVLIAAKTADDVKINTAAMRAILQGELDQMAHNFDPTTTVDDYLAIARGKTARLFSLSCEQGAHFAGADASVVKLAQQIGERMGLAYQMLDDVLDYAGDEALTQKPVLNDLRDGVYSLPLIYALTAEPQLAEQLPQPGDHISNEQLLTIRDQVIALGGVTQAQQLATHYTKTALNLIDQLPTGETQQTLRRLVTELLVRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN04</accession>
    <name>F9UN04_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps2J</name>
        <name evidence="3" type="ordered locus">lp_1206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101307.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1206"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78593">
        <property type="protein sequence ID" value="CCC78593"/>
        <property type="gene ID" value="lp_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1206"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1024"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_33_0_9"/>
    <dbReference type="OMA" id="VRICHSH"/>
    <dbReference type="PhylomeDB" id="F9UN04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1036-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="157"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="341" mass="40166" checksum="8D9112CCBB6CACA2" modified="2011-10-19" version="1">MSIYRKIDRNKIQFDFIVHKTGKNFFEDEILKLGGRIYRLPNKRKHPFKYKQEFLNVIKNYKIIHVHSVYAFTYYEVKWARQCQKSVILHSHNSDAKLLRKIIHYLFKHLQNHYVSVRLSPSKQAAKWMFNEGHDKVVYLYNGFDTTKFQFDMNSRIEIREQLGLANNDYIIGCVGRLDWQKDPIYLLRLFEKLKANDNAYKLIFIGDGSYRQTLERETHQKGLVNDVIFTGSVSNVPEYLSALDIFVLPTRYEGLGISLIEAQINGLPVFTNKDVPKEAVINQNMYLLDKGDSELWVDAINKELNVINLKKRKVNLSDFNQYNIETVVKKLQNIYLQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN74</accession>
    <name>F9UN74_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese transport protein MntH, Nramp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mntH2</name>
        <name evidence="6" type="ordered locus">lp_1295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889177.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1295"/>
    <dbReference type="EnsemblBacteria" id="CCC78663">
        <property type="protein sequence ID" value="CCC78663"/>
        <property type="gene ID" value="lp_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1295"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1095"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_9"/>
    <dbReference type="OMA" id="QCLCAKL"/>
    <dbReference type="PhylomeDB" id="F9UN74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1121-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="441" mass="47636" checksum="7D727789125FEAA0" modified="2011-10-19" version="1">MQSHRHQSLEEINQSVAVPDVHQTAFWRKFLAYSGPGALVAVGYMDPGNWLTSLAGGGQFQYRLLAVLALAIIVAMFMQGLAIRLGVVARQDLAQAIASKLPRPVRYAAWILNEVAMMATDMTGVIGTAIALKMLFGLPLLAGILLTIADVLVVLLFLRFGIRRVEVIVLVAILTVGIIFGIEVGRAHVQFGNVLLGLVPTPLIVKNHTALVLSLGILGATIMPHNLYLHSSLAQSRRYDYHNPAQVTEALRFANWDSTVHLIAAFLINALLLVLGGTLFFGHTNALASLQAVFDGLKSTTVVGALASPVMSWLFALALLITGLISSITSTLAGQIVMEGYLHIRLPLWQRRLLTRAVTLIPILIIGMLVGFSDAAFENLIIYAQVALSIALPFTLLPLVALTNDASLMKAHVNRPAVTWVGYGLAGIITVLNIYLVYSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH1</accession>
    <name>F9UNH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1422"/>
    <dbReference type="EnsemblBacteria" id="CCC78760">
        <property type="protein sequence ID" value="CCC78760"/>
        <property type="gene ID" value="lp_1422"/>
    </dbReference>
    <dbReference type="GeneID" id="57025051"/>
    <dbReference type="KEGG" id="lpl:lp_1422"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1192"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="NIDCYIG"/>
    <dbReference type="PhylomeDB" id="F9UNH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1221-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="315" mass="35591" checksum="851F9875397C013C" modified="2011-10-19" version="1">MPKSDSSEMRRFLDVLLKHGNFTRAAKDLYISQPYLTQSIRNVEKELGVTIINREVTPLRLTTAGRTYYQYLTALENEKDYFNKQIRQYTHANQQVIRLGVLSSLGYYLLPLFLPAFLKAHPATKIELTEDIASRNEQRVLHGELDFLIGQNPETIAPGLESYDRGRDGYYAIIPNTVNWYQPHQAFINPGALPLNDLLQAPLVLSPHGSSIRRQVDYLLQKHNVTPNIVIESTNTATITKLATAGLGITFLPDSVHTQPDPERYNILPLPQALMSLNYFIAFPAEHSLNQVEKDLVTIFLTQLEADLAQSSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ1</accession>
    <name>F9UNJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101411.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889294.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1449"/>
    <dbReference type="EnsemblBacteria" id="CCC78780">
        <property type="protein sequence ID" value="CCC78780"/>
        <property type="gene ID" value="lp_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1449"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1213"/>
    <dbReference type="eggNOG" id="ENOG5033XZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_3_1_9"/>
    <dbReference type="OMA" id="TTANGWQ"/>
    <dbReference type="PhylomeDB" id="F9UNJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1241-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394391" evidence="2">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="26"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="23443" checksum="6490D2A0A794D8FF" modified="2011-10-19" version="1">MFNRFCLSTGLAILGLMATSLTAIGATTNGTVTFQDDTSATAPVDPTSPNVPLTTTDPNNPATNNTGTLTLDVAPKTIDFGTVTTSNAAKTYTAIGNYNQYLQVSDKRTTANGWQVNVKQDRTLTNASNNHVLTGAVIHLPQGTARNSLNEPASVADSNLVVAPSVSVTTADQVVFSAPNRAGVGKATSTNTWNAGAVTLSIPKLTAQVGNYTNNLVWTLVAATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM4</accession>
    <name>F9UNM4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1485"/>
    <dbReference type="EnsemblBacteria" id="CCC78813">
        <property type="protein sequence ID" value="CCC78813"/>
        <property type="gene ID" value="lp_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1485"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1247"/>
    <dbReference type="eggNOG" id="ENOG50309IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862732_0_0_9"/>
    <dbReference type="OMA" id="VENQEAT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1274-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="326" mass="37377" checksum="E8A964A4D5947A49" modified="2011-10-19" version="1">MDIQEKLNAKYDNIAIYTSGFYADPEDELGTRSKLSETLKSFTMNQHADTPFSLQIMTTNGEINVMPLGLLSLDELKAYETKRREQAGLTTDDDAIPLVVQFAPHTEKGQIQKQIVGTTQNLFDNFNTHFAAIWTVVKADLQANQTLLVGIERDLISDSADIQREYQDNFKLMDAPTRKAKLGFDLKDTDLTHFSTFMADMHEIQAIVLSSAAFVKNELLGDDLFAQVMNDKVSRNTLFWVLDNTFYETLYYFIEKYRDIANGKKLTRHLHHQKKLLIINMRNDAYQRAQAAVEDATTKLDMDKYFSDIFVPIAEQLAREVDQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN0</accession>
    <name>F9UNN0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-guanine dinucleotide biosynthesis protein MobA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mobA</name>
        <name evidence="5" type="ordered locus">lp_1491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889333.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1491"/>
    <dbReference type="EnsemblBacteria" id="CCC78819">
        <property type="protein sequence ID" value="CCC78819"/>
        <property type="gene ID" value="lp_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1491"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1253"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_4_0_9"/>
    <dbReference type="OMA" id="QANHYLV"/>
    <dbReference type="PhylomeDB" id="F9UNN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1280-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="20592" checksum="75A0274C9B6506CB" modified="2011-10-19" version="1">MLGIVLAGGQSKRFGRDKAQVQLPGQPLNNVGLAVTKLQLLCEQVIVSASQQNVANLTEQFQTSSNVIVVTDQVPFERQGPLSGIFAATNYSPELTDYLLLAVDYPLITTTILTTLVTQTDCYATTPTQDHYLVSHVQASQDMVRAHLLLGDLRVSHFIKTTCQGLPVTFPDSQAFTNLNNMEALTNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ0</accession>
    <name>F9UNQ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Primosomal protein DnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaI</name>
        <name evidence="3" type="ordered locus">lp_1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889353.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1513"/>
    <dbReference type="EnsemblBacteria" id="CCC78839">
        <property type="protein sequence ID" value="CCC78839"/>
        <property type="gene ID" value="lp_1513"/>
    </dbReference>
    <dbReference type="GeneID" id="57025110"/>
    <dbReference type="GeneID" id="66449399"/>
    <dbReference type="KEGG" id="lpl:lp_1513"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1273"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077384_1_0_9"/>
    <dbReference type="OMA" id="HFTYSQR"/>
    <dbReference type="PhylomeDB" id="F9UNQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1300-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009928">
        <property type="entry name" value="DnaI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07319">
        <property type="entry name" value="DnaI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaI_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="311" mass="35249" checksum="F214440BB2DA1052" modified="2011-10-19" version="1">MENISETLRTLMNRKNLNHRYEALMTAVYQDPDVRQFLAAHQNELSSDALERSAAKLYEFCEEKRKIARHEPTQAPGYQPTLVMSNHLIDIAYQPTPQMQEQQAAHALQQRVRSISMPKNIQTADLKTYDQDGDRATALMAALDFIDAYTQAPKRFHRGLYLYGSFGVGKTYLLGGMANALAAKGFNTTLIHFPSFAVEMKRSISNNTSADKVDAIKRAPILMIDDIGADASSTWIRDDVLGVILEYRMQEELPTCFSSNFSMQELQDGYLTLSQKGDEEPVKAQRIMQRVRYLASEIEMVGRNRRLNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP79</accession>
    <name>F9UP79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabT</name>
        <name evidence="3" type="ordered locus">lp_1721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101522.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889532.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1721"/>
    <dbReference type="EnsemblBacteria" id="CCC79018">
        <property type="protein sequence ID" value="CCC79018"/>
        <property type="gene ID" value="lp_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1721"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1453"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_9"/>
    <dbReference type="OMA" id="MVPNYNP"/>
    <dbReference type="PhylomeDB" id="F9UP79"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1481-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="449" mass="49491" checksum="E2CD4FEF25F69E0C" modified="2011-10-19" version="1">MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAINVGHTHPRVVKAIQEQAAKLIHYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDANDAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNMVRKMGPLLPGIVHVPYPDCYRTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDFCHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVMESLAAPAHTFTTAANPVCCAAALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQVRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVMITLKGNILRFQPPLVITKTQLDTALTVLDEAMAAAEQGLVKRPQGKIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP85</accession>
    <name>F9UP85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mapA</name>
        <name evidence="7" type="ordered locus">lp_1730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640464.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889538.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1730"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79024">
        <property type="protein sequence ID" value="CCC79024"/>
        <property type="gene ID" value="lp_1730"/>
    </dbReference>
    <dbReference type="GeneID" id="57025353"/>
    <dbReference type="KEGG" id="lpl:lp_1730"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1459"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_2_9"/>
    <dbReference type="OMA" id="EAYCIPF"/>
    <dbReference type="PhylomeDB" id="F9UP85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1487-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050082">
        <property type="term" value="F:maltose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="318"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="695"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="587"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="748" mass="85675" checksum="D1F793496814D375" modified="2011-10-19" version="1">MKRIFDVNPWHVLTTDFKPENKRLQESMTSLGNGYMGMRGFFEEDYTGDTLPGIYLGGVWYPDKTRVGWWKNGYPEYFGKVINAVNFIKINFKLNGTKIDLATANFSDFKLDLDMQHGTLTRSFIVDQDGQRVRVTFERFLSVAQKELSVQKVTFENLSDQAVELKVASALDADVKNEDANYDEHFWNVHEVTDDRLIAQTVPNDFGTPQFTSGMQVSYVTSLTHKAAEVTDTATVDRYFGTLEAGASVSFEKRVVVVTSRDYPTDDAIMTALQRLTDTVSAQSFDDLLAAHEAGWADRWQQSDIQIEGDTEAQQGMRFNLFELFSTYYGDDPRLNIGPKGFTGEKYGGATYWDTEAFAVPVYLGITKPEVTRNLLMYRYKQLDGAYHNARQQGLDGALFPMVTFNGIECHNEWEITFEEIHRNGDIAFAIYNYTRYTGDTSYVLHEGSKVLTEISRFWADRVHFSKRNQQYMIHGVTGPDEYENNVDNNFNTNYLAQWTLKYTLEILDQVSDDQAAALNVTAEERAHWQDIVDRMYLPYDKDLDIFVQHDGYLDKDLAPVSAIPADQLPINQHWSWDHILRSPYIKQGDVLQVMYDFIDDFSKTQLKHNFDFYEPMTVHESSLSPAIHAVLAADLHYEDKAVAFYNRTARLDLDNYNNDTVDGLHITSMTGGWIAMVQGFAGMRVHDGQLSYRPFLPKQWTKYSFRQVFRDRIIEVTVDHDGTTLKLIAGEPIDVQVDGTTQTLTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB1</accession>
    <name>F9UPB1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_1759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889605.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1807"/>
    <dbReference type="EnsemblBacteria" id="CCC79091">
        <property type="protein sequence ID" value="CCC79091"/>
        <property type="gene ID" value="lp_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1807"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1526"/>
    <dbReference type="eggNOG" id="COG4420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077948_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UPF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1554-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="28383" checksum="DD77C5AC687A19B1" modified="2011-10-19" version="1">MAKTAVCIVDQQRYQVVDGMRLEELETSLRQMILKDFPQAHNSSFICSEHLVHYRLAKMDAMIENDYQQNDKVNAQLSKILANHTYRVVDVNSELESSLTFGQRVADGVARFGGSWAFIISFVVVMLVWMLLNVLPIFSHHFDPYPFILLNLFLSMVAAIQAPLIMMSQNRAAEYDRLQAANDFKVNSMSEEEIRVLHSKVDHLIQQDEPNMLEIQKMQTQMLGEIQAQVNELRRLQPRRRRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPK6</accession>
    <name>F9UPK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1877"/>
    <dbReference type="EnsemblBacteria" id="CCC79145">
        <property type="protein sequence ID" value="CCC79145"/>
        <property type="gene ID" value="lp_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1877"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1582"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032389_1_0_9"/>
    <dbReference type="OMA" id="PYCEVAW"/>
    <dbReference type="PhylomeDB" id="F9UPK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1607-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="422" mass="48806" checksum="9B7C5CAA21726BD2" modified="2011-10-19" version="1">MSYSEKMLAALSNGQIDTAKKHFAWALRKDDDQTLYSLAEELYGLGFLKQAERTYKKLLAKYPDEDDLRTSLADIAIDEDDTDLALDYLQQVKPDSPAYVQALLVEADLYQTQELFEVSEQKLKEAYQLAPDEPVVEFALAEFYFLIRNYGQATRFYLDLIKQGQLEISKVNLVERLGVAYAESGRFEQAVGYLEQIKPAKLTPDSQFELGFTYLQLNEPQKAVDIFDKLREQDNQYASLYPYLAQAQEQLHQLDKALLTLQEGLAVDQYNEQLYLQTARLALKLDDQELAEKYLREGLSIDPDNLTTVLELSNLLVQRERYQDNIDLLDQYLQSNEFDPQFYWNLAISNDRLDHFQAAKDNYEAAYPFFEHNKDFLKPAIYFFREAGMADSAVAALRNYLTIEPDDGEMVAMLEDYEDQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL5</accession>
    <name>F9UPL5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101582.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889668.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1887"/>
    <dbReference type="EnsemblBacteria" id="CCC79154">
        <property type="protein sequence ID" value="CCC79154"/>
        <property type="gene ID" value="lp_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1887"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1590"/>
    <dbReference type="eggNOG" id="COG3601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086673_2_2_9"/>
    <dbReference type="OMA" id="MFLEFPI"/>
    <dbReference type="PhylomeDB" id="F9UPL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1616-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="21474" checksum="0BDDD5C75FB8A8D6" modified="2011-10-19" version="1">MQHTTLHLLVGIALLGAIAYILMLLEFPILPVAPWMKIDFSDIPILIGLFLFGVGGAFVITIIKLLLHSAMMGFAIYDLIGSFASFLGTAVLILAFALVLRYYRGNPKWRMPVAIVVATIGLVVIESLANLTFVLPFYLQVMGMKLSMSLNTVVLVAVIPFNLIKGLLVGNVFWLVYQRLAKWLGNHNQLMSRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-10-16" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPU7</accession>
    <name>KT3K_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable ketoamine kinase lp_1983</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="FEBS J." volume="274" first="4360" last="4374">
            <title>Many fructosamine 3-kinase homologues in bacteria are ribulosamine/erythrulosamine 3-kinases potentially involved in protein deglycation.</title>
            <authorList>
                <person name="Gemayel R."/>
                <person name="Fortpied J."/>
                <person name="Rzem R."/>
                <person name="Vertommen D."/>
                <person name="Veiga-da-Cunha M."/>
                <person name="Van Schaftingen E."/>
            </authorList>
            <dbReference type="PubMed" id="17681011"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2007.05948.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Ketoamine kinase that phosphorylates ketoamines, such as erythruloselysine, erythrulosecadaverine, ribuloselysine and ribulosecadaverine, on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (PubMed:17681011). Has higher activity on free lysine (erythruloselysine and ribuloselysine), than on ribuloselysine and erythruloselysine residues on glycated proteins (PubMed:17681011).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine</text>
            <dbReference type="Rhea" id="RHEA:61400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144590"/>
            <dbReference type="ChEBI" id="CHEBI:144611"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:61401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine</text>
            <dbReference type="Rhea" id="RHEA:61404"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144612"/>
            <dbReference type="ChEBI" id="CHEBI:144614"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:61405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine</text>
            <dbReference type="Rhea" id="RHEA:61408"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144617"/>
            <dbReference type="ChEBI" id="CHEBI:144618"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:61409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine</text>
            <dbReference type="Rhea" id="RHEA:61412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144619"/>
            <dbReference type="ChEBI" id="CHEBI:144620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:61413"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:61396"/>
            <dbReference type="Rhea" id="RHEA-COMP:15794"/>
            <dbReference type="Rhea" id="RHEA-COMP:15799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144587"/>
            <dbReference type="ChEBI" id="CHEBI:144624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:61397"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">300 uM for free ribuloselysine</KM>
            <KM evidence="3">340 uM for free ribulosecadaverine</KM>
            <KM evidence="3">60 uM for free erythruloselysine</KM>
            <KM evidence="3">63 uM for free erythrulosecadaverine</KM>
            <Vmax evidence="3">510.0 nmol/min/mg enzyme with free ribuloselysine as substrate</Vmax>
            <Vmax evidence="3">2860.0 nmol/min/mg enzyme with free ribulosecadaverine as substrate</Vmax>
            <Vmax evidence="3">610.0 nmol/min/mg enzyme with free erythruloselysine as substrate</Vmax>
            <Vmax evidence="3">800.0 nmol/min/mg enzyme with free erythrulosecadaverine as substrate</Vmax>
            <Vmax evidence="3">16.0 nmol/min/mg enzyme with ribuloselysyl-protein (lysozyme) as substrate</Vmax>
            <Vmax evidence="3">3.8 nmol/min/mg enzyme with erythruloselysyl-protein (lysozyme) as substrate</Vmax>
        </kinetics>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UPU7"/>
    <dbReference type="SMR" id="F9UPU7"/>
    <dbReference type="DNASU" id="1064115"/>
    <dbReference type="EnsemblBacteria" id="CCC79236">
        <property type="protein sequence ID" value="CCC79236"/>
        <property type="gene ID" value="lp_1983"/>
    </dbReference>
    <dbReference type="GeneID" id="57025561"/>
    <dbReference type="KEGG" id="lpl:lp_1983"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1676"/>
    <dbReference type="eggNOG" id="COG3001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_1_9"/>
    <dbReference type="OMA" id="GSFYSAY"/>
    <dbReference type="PhylomeDB" id="F9UPU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1700-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000448291" description="Probable ketoamine kinase lp_1983">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P9WI99"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9HA64"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17681011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="31841" checksum="9E5FEF8E7AAE1B6F" modified="2011-10-19" version="1">MHLTKTWLAQLPLTDIQQVQPVSGGDINAAFQIITRHHQYFLKVQPHNDVTFFDHEVAGLRLLGAVTKTPRVIASGTIATDGYLLLDWLATGTGSQSALGAAVAKVHHQHHAQFGLDHDFTAGKLPKINHWQTDWATFYTQQRLDVLVNLAKEHHLWSETREMHYHRLRQQLLQDSHMHTVKPSLLHGDLWSGNYLFDTTGTPVLIDPDVFYGDREMDLAMTTIFGGFDTDFYQAYQAAYPVAPGMQDRLPSYQLYYLLAHLNLFGETYGPAVDRILMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV1</accession>
    <name>F9UPV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640697.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889754.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1988"/>
    <dbReference type="EnsemblBacteria" id="CCC79240">
        <property type="protein sequence ID" value="CCC79240"/>
        <property type="gene ID" value="lp_1988"/>
    </dbReference>
    <dbReference type="GeneID" id="57025565"/>
    <dbReference type="KEGG" id="lpl:lp_1988"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1680"/>
    <dbReference type="eggNOG" id="ENOG5030A40">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172478_0_0_9"/>
    <dbReference type="OMA" id="AYLSWAM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1704-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="13043" checksum="C027E50A23BDA332" modified="2011-10-19" version="1">MTEKIRKFNGQYWLIALVVGVMIPWLLRFTSISRFHQIVWLLFVVDFVLAAVVGWWIRRTERTGWLVWLFPVGCFVGLYLFFPTYVYYLALVDLGISYLAYGLTGPRASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW0</accession>
    <name>F9UPW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101619.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2001"/>
    <dbReference type="EnsemblBacteria" id="CCC79249">
        <property type="protein sequence ID" value="CCC79249"/>
        <property type="gene ID" value="lp_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2001"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1690"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182189_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1713-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025037">
        <property type="entry name" value="DUF3923"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13061">
        <property type="entry name" value="DUF3923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="70" mass="8239" checksum="9DB852B890F04EE3" modified="2011-10-19" version="1">MKKSWIIVSIFEILIYMLLSLLIFNRSIDGSGVVQTPELKMITWYILNVPFAFLLIAQIIWFVIIKKHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ11</accession>
    <name>F9UQ11_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily</fullName>
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            <ecNumber evidence="1">3.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2056</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EC" id="3.1.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889814.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2056"/>
    <dbReference type="DNASU" id="1061963"/>
    <dbReference type="EnsemblBacteria" id="CCC79300">
        <property type="protein sequence ID" value="CCC79300"/>
        <property type="gene ID" value="lp_2056"/>
    </dbReference>
    <dbReference type="GeneID" id="57025606"/>
    <dbReference type="KEGG" id="lpl:lp_2056"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1741"/>
    <dbReference type="eggNOG" id="COG1011">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_9"/>
    <dbReference type="OMA" id="FEAILCA"/>
    <dbReference type="PhylomeDB" id="F9UQ11"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1761-MON"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
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        <property type="entry name" value="HAD_2"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="26983" checksum="1BFF956524ED9640" modified="2011-10-19" version="1">MIKAIIFDLDDTLYDQKSPFTAALTKTFNQALSSTELAQIFNRFHDFNDRTFNQVTDTTMTLEAWQTARIRHALAPSKVHISTDRAIQFEMAYQQELNQICLFDGLSATLTKLSHAFKIGIITNGPAPIQHQKLHQLQIEHFVHPDNIFISEELGIAKPDPSIFTTWAHQVGIKANEAVYVGDNAALDMTSAKHAGWQTFWFNHRRNDQVTPSVIPDQIIQSPAELNELLLALLQAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ22</accession>
    <name>F9UQ22_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889825.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2068"/>
    <dbReference type="EnsemblBacteria" id="CCC79311">
        <property type="protein sequence ID" value="CCC79311"/>
        <property type="gene ID" value="lp_2068"/>
    </dbReference>
    <dbReference type="GeneID" id="57025617"/>
    <dbReference type="KEGG" id="lpl:lp_2068"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1753"/>
    <dbReference type="eggNOG" id="ENOG50309WT">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1935375_0_0_9"/>
    <dbReference type="OMA" id="NDNREPD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1771-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="14844" checksum="9679095105949105" modified="2011-10-19" version="1">MDFVELTPIALGHTPLGTRGPNPHIHDWQLDWQKLSSLIADNQDVMMQVDAGLAEDWLNTHGTIWDNVQGYHRYPNDNRAFDDTVFWAASTWATPAIVVTFHNEISRAFSCYRVGTDPDFHYLGPRGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ59</accession>
    <name>F9UQ59_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640792.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889862.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2112"/>
    <dbReference type="EnsemblBacteria" id="CCC79348">
        <property type="protein sequence ID" value="CCC79348"/>
        <property type="gene ID" value="lp_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2112"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1789"/>
    <dbReference type="eggNOG" id="ENOG5032MPT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3008676_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1809-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="56" mass="6438" checksum="78C141687E7FF005" modified="2011-10-19" version="1">MSLKVQRQDNLDKLFDKFAIGPDDKDKLTTKAVQDTIDEHAKRKENKAADKKDAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ81</accession>
    <name>F9UQ81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW</name>
        <name evidence="7" type="ordered locus">lp_2137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645668.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889884.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2137"/>
    <dbReference type="EnsemblBacteria" id="CCC79370">
        <property type="protein sequence ID" value="CCC79370"/>
        <property type="gene ID" value="lp_2137"/>
    </dbReference>
    <dbReference type="GeneID" id="57025676"/>
    <dbReference type="KEGG" id="lpl:lp_2137"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1811"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_1_9"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="PhylomeDB" id="F9UQ81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1831-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="388" mass="41923" checksum="29BA27FEEE4F1099" modified="2011-10-19" version="1">MWKKLHYMDYVLFIPYLILSGIGVVMVYSSSSYVAAQNGSTPTGYLVKQLIWVVLGLVITLVCMNLKIDYFKQTKLLGMLGFAMLFVLVLLRLVGQSINGAAGWIILGPVSIQPAEFCKFYLIIYLASIISQREAHFGVARIRELGAQFVMLFAMILLIFVQPDLGGATINLAIAAVILFASGISYFVGVGVFAGAVAAFEWILVPLVSRMPQSAFANSYQLRRFLGFLNPFKTASGAGTQLVNSYYAISNGGLTGVGIGNSLQKRGYLPEPNTDFIMSITAEELGLIGILIVMGLLLVIVMRTIYIGVRATNTFNALVCYGVAAYMTIQAFINVGGIVGLIPITGVTFPFMSYGGSSMMVLTLSLGLVLNISALEKMARLNTVRQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB6</accession>
    <name>F9UQB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644606.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2183"/>
    <dbReference type="EnsemblBacteria" id="CCC79405">
        <property type="protein sequence ID" value="CCC79405"/>
        <property type="gene ID" value="lp_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2183"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1846"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_1_9"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="PhylomeDB" id="F9UQB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1866-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20509" checksum="1B8D9159CDE5A93A" modified="2011-10-19" version="1">MTFEERVQSRQLVYQGGLVQVERQEVTLPDQTTATREIVRHQPAVAMLMITAQHKMIVEQQWRAATGGLTVEIPAGKVESGETMDQAAVRELNEETRLTAQHLEAVAQFYTSPGFTDELMKLYVATGLSVVATAFPQDPDEQIRLIKLDLATAVSQVQTGQIQDAKTVMAIWYWQSHPELGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF6</accession>
    <name>F9UQF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, S1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">lp_2231b</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644624.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889959.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2231b"/>
    <dbReference type="EnsemblBacteria" id="CCC79445">
        <property type="protein sequence ID" value="CCC79445"/>
        <property type="gene ID" value="lp_2231b"/>
    </dbReference>
    <dbReference type="GeneID" id="57025781"/>
    <dbReference type="KEGG" id="lpl:lp_2231b"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1887"/>
    <dbReference type="eggNOG" id="COG1098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128762_1_0_9"/>
    <dbReference type="OMA" id="HISECKT"/>
    <dbReference type="PhylomeDB" id="F9UQF6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1930-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="15439" checksum="D24B0EDF01D2FE11" modified="2011-10-19" version="1">MIVSNYRIGMRVHGRVTGIQPYGAFVTLDGEHQGLIHISECHEGYVKSITEYLKVGQAVDVIILDIDEYTGKISLSLRCIEHQPHPTVNDLEIYKTFRHKHFWTNRHVHAGFEPIANHLASWTSDSLNRLKAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG3</accession>
    <name>F9UQG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641558.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2238"/>
    <dbReference type="EnsemblBacteria" id="CCC79452">
        <property type="protein sequence ID" value="CCC79452"/>
        <property type="gene ID" value="lp_2238"/>
    </dbReference>
    <dbReference type="GeneID" id="57025788"/>
    <dbReference type="KEGG" id="lpl:lp_2238"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1894"/>
    <dbReference type="eggNOG" id="COG4186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092313_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1937-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="202" mass="23399" checksum="45A8F90EDC7A8BB9" modified="2011-10-19" version="1">MQYFTSDTHFYHADLLGDNDFAPRLFPDVETMNQAIVDHWNARVTDQDTVYHLGDVALYFTRPAKLSYERVFALLAQLNGKIIFIKGNHDSRAFFKYLAAHDPQLNGQPKFEFHDVGVLIKYDHRQYYMTHYPMMMGIVKQIINLHGHIHHYAVNVKENINVGVDTPEVDYLDHPVPFGTPFSLAEIEQMVDGKAIDFAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI0</accession>
    <name>F9UQI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641537.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889983.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2261"/>
    <dbReference type="EnsemblBacteria" id="CCC79469">
        <property type="protein sequence ID" value="CCC79469"/>
        <property type="gene ID" value="lp_2261"/>
    </dbReference>
    <dbReference type="GeneID" id="57025806"/>
    <dbReference type="GeneID" id="66450018"/>
    <dbReference type="KEGG" id="lpl:lp_2261"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1912"/>
    <dbReference type="eggNOG" id="COG4768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115870_4_2_9"/>
    <dbReference type="OMA" id="KTNDLMT"/>
    <dbReference type="PhylomeDB" id="F9UQI0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1954-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="138" mass="15019" checksum="528CBBE53751EE10" modified="2011-10-19" version="1">MITHIAGIIAAIAFLLLVCFIGIFLMRITKTMGEVNRSLNNITDDVDALSHETEKIMANANELLKDVNGKVATIDPAFQAMGDLGQSVSDLNAATRDLTAKIGKNNEKRSKFSSASKVGKAAFDVYRNRRSKNNSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP6</accession>
    <name>F9UQP6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2342"/>
    <dbReference type="EnsemblBacteria" id="CCC79535">
        <property type="protein sequence ID" value="CCC79535"/>
        <property type="gene ID" value="lp_2342"/>
    </dbReference>
    <dbReference type="GeneID" id="57025879"/>
    <dbReference type="KEGG" id="lpl:lp_2342"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1980"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053304_2_0_9"/>
    <dbReference type="OMA" id="ELANGIC"/>
    <dbReference type="PhylomeDB" id="F9UQP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2019-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="34204" checksum="1C76F8823F8B5D17" modified="2011-10-19" version="1">MRILGEKVRQFRKRKGMSQKELADGICTQATISLIEKKSKIPSMKIMMKICNRLGIRLSEVIIENDDQLYRTFKKIDTLIRHTQLEEAQDVFQHIRPKQLRSNTDKKQYYYYEGYLQLVLNDNADEAIFNFGMLLNQFVKSSHDMFAILATLGTGLAYERKQAYDKAEIFVKQAVATLHTMDAQAMPMGDDDYLQNEILIYASAAQLYAKINFPEEALELIDLALKKAQESQSLYLLDRLYAQKAANEVVLNNVQSAHDHYYVAYALSLVTHNSSLTEKITKEMAEYHIAPLQVANDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR67</accession>
    <name>F9UR67_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642721.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2550"/>
    <dbReference type="EnsemblBacteria" id="CCC79706">
        <property type="protein sequence ID" value="CCC79706"/>
        <property type="gene ID" value="lp_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2550"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2142"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_4_9"/>
    <dbReference type="OMA" id="YHIHIGD"/>
    <dbReference type="PhylomeDB" id="F9UR67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2198-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="19679" checksum="FD5F5E4BFCFDF3AB" modified="2011-10-19" version="1">MSELDKLAAGEWYQFKDAEVAAQKARAAKLCQEFNQIDATNPDAQTAKIQEILGSYGRNLSVQADFNCDNGRNIHVGDNFLSNYNLTILDIAPVHIGDNVMIGPNVDIYTVNHPLTASGRRASLAQGHPVTIGHDVWIGGRAVITPGVTIGNNVVIAAGAVVTHDMPDNTLVAGVPAKVIRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR93</accession>
    <name>F9UR93_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ4</name>
        <name evidence="3" type="ordered locus">lp_2582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2582"/>
    <dbReference type="EnsemblBacteria" id="CCC79732">
        <property type="protein sequence ID" value="CCC79732"/>
        <property type="gene ID" value="lp_2582"/>
    </dbReference>
    <dbReference type="GeneID" id="57025994"/>
    <dbReference type="KEGG" id="lpl:lp_2582"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2169"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_15_2_9"/>
    <dbReference type="OMA" id="FITMVLN"/>
    <dbReference type="PhylomeDB" id="F9UR93"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2224-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="343"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="597" mass="68609" checksum="F85E8AC0FCC1A26D" modified="2011-10-19" version="1">MGAWRFWWDSTRRFYKNWGSYVALIFSTNLVISYLAIPFFNWVLEMLLKWQRVSYVSYTNIGSIIIHQPLAALGMVAILLAIIILVYWQFAFLLLGIMNIFRGRPQTVRAVLRSTVTSLTGTSPSTFLFFIGYFIVILPFGSFIFTTPLLNKAKIPAFIVSYLMENPWMTLGLGCFYLLAGYLGIRLISLLPLMIVDRLPWKTAVTRSWQQTRHHLWRYLWTMIVTLFMIFLIVTTIYTLIYVAQLQFDKTSFAMAAATVNLFIMEAITEIIICYTTAIFMMLIIVCYRQDFTLLRQQPQYFNEAPRLRKLTRASVAIGLLLATSLLVAVNLVYLNGLVITKPIMISHRGVDNGNGVQNTIPALIKTSKEHPDYVEMDIQVTKDHQFVVMHDPTLKALAGVKKKPSQLTLKQLEKITVRENGYQAKIPSFDAYLKAAHKHHQKLLVEIKTSSAYTAADTKRFIDRYGATLLAHHDQVHTLSFKVMRDLKRLDQKQFVSYILPYNLTFPHTVANGYTMEVTTLNDQFVDKADRNHKTVYAWDIDNTDQMDQMMFMGVTGVVTDNLTEMQQEVKSNTDHPSYAKLLLTFMNELSLTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN6</accession>
    <name>F9URN6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890389.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2765"/>
    <dbReference type="EnsemblBacteria" id="CCC79875">
        <property type="protein sequence ID" value="CCC79875"/>
        <property type="gene ID" value="lp_2765"/>
    </dbReference>
    <dbReference type="GeneID" id="57026136"/>
    <dbReference type="KEGG" id="lpl:lp_2765"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2315"/>
    <dbReference type="eggNOG" id="ENOG50330X0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141519_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9URN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2366-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021361">
        <property type="entry name" value="DUF2829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11195">
        <property type="entry name" value="DUF2829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="73" mass="8244" checksum="AAE4B18F0981BEB6" modified="2011-10-19" version="1">MTFEAILPELKAGKRAVRTGWEGTELFVELQTATTFNGDPLNPYFLIKTADEAYSMWSPTDCDILATDWQLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS3</accession>
    <name>F9URS3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase, family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890426.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2810"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79912">
        <property type="protein sequence ID" value="CCC79912"/>
        <property type="gene ID" value="lp_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2810"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2352"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053311_0_0_9"/>
    <dbReference type="OMA" id="DAQWIGA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2408-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389073" evidence="3">
        <location>
            <begin position="27"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="432" mass="49051" checksum="6D3E56B56372D692" modified="2011-10-19" version="1">MGIKRLSWLVGTAVVATLGMQITVQAQGHAVVDISEWQGQLSPSQVQAMKSQVLFVINRRQYGLNYVDRDAANNTALYVRYGIPFGEYDFSQFTDAASARREAQAFYARSNKAARFYALDFEVNTVRSGSTNAAVAAWYREMRALTNKKLIFYSYASFALTYANQARQRFDAQWIGALTPNPPIISAALWQYTNRYHLAGLAAPVDNSRVITSVHPVSWWLGTAHGAPSVVIKAQPRLKVMHDRHLTMPAHNQQHGRAGQAVVAIKRPAVQPAVKTRPVQQKAVSNKSRSQTVVRVKRRSLQTISVNSHHGKITQHRVIRRRATQPKVIKLKATRRTGTQFKLNTSKATKLRRPGKSIRTKPVARSKGRTRQRLTRRQPSLRQRVTRNRQSRRHTLRVTVQRRGSTIRRAPRRQRIQIRPVHNTSRDKRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9US23</accession>
    <name>F9US23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890526.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2939"/>
    <dbReference type="EnsemblBacteria" id="CCC80012">
        <property type="protein sequence ID" value="CCC80012"/>
        <property type="gene ID" value="lp_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2939"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2454"/>
    <dbReference type="eggNOG" id="ENOG5030AMQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2862191_0_0_9"/>
    <dbReference type="OMA" id="GIFFRYM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2508-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="65" mass="7330" checksum="077EC0A9C136E3B5" modified="2011-10-19" version="1">MMMMTGMMVLFVLLVGLVLSGIFFRYMDTTAGISFSSLKFADLRMELLNLVLVIGLLLWALVLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9US56</accession>
    <name>F9US56_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-phosphoglucomutase</fullName>
            <ecNumber evidence="5">5.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pgmB1</name>
        <name evidence="5" type="ordered locus">lp_0027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.6" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641651.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0027"/>
    <dbReference type="EnsemblBacteria" id="CCC77603">
        <property type="protein sequence ID" value="CCC77603"/>
        <property type="gene ID" value="lp_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="57026888"/>
    <dbReference type="KEGG" id="lpl:lp_0027"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.25"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_9"/>
    <dbReference type="OMA" id="ANGYHIV"/>
    <dbReference type="PhylomeDB" id="F9US56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-24-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02598">
        <property type="entry name" value="HAD_BPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010972">
        <property type="entry name" value="Beta-phosphoglucomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01990">
        <property type="entry name" value="bPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="223" mass="23663" checksum="D594E87119A78EDD" modified="2011-10-19" version="1">MVKFAAIKGFVFDLDGVITDTSTFHSQAWHQIADKVGVSWNDQLADALKGISRMDSLNLILAQGHRENDFTPAQKQALATEKNTNYLQLVNQMTPANILPGITAFLTELTTAGYALSLASASKNAPLVLRKLGLSDYFTKAVDPASLKHGKPDPEIFRRGAEILGLNPADCIGVEDAAAGVQSIKGAGETAIGIGDPTVLAAADINFTDTTQLTLANIKAQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9US60</accession>
    <name>F9US60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77607">
        <property type="protein sequence ID" value="CCC77607"/>
        <property type="gene ID" value="lp_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="57026892"/>
    <dbReference type="GeneID" id="66448185"/>
    <dbReference type="KEGG" id="lpl:lp_0032"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.29"/>
    <dbReference type="eggNOG" id="ENOG502ZP4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188348_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9US60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-28-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8423" checksum="56A53AC785A968A6" modified="2011-10-19" version="1">MDFVDVYGIKHENCTLVAPAREYQRVVIFMDALGRRFVAMGPDPQPTKYGSSSQHWHQAQPSAAPEGYFHIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9US76</accession>
    <name>F9US76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Divalent anion:sodium (Na+) symporter, DASS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77623">
        <property type="protein sequence ID" value="CCC77623"/>
        <property type="gene ID" value="lp_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0056"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.45"/>
    <dbReference type="eggNOG" id="COG0471">
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    <dbReference type="OMA" id="YAWHFFA"/>
    <dbReference type="PhylomeDB" id="F9US76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-45-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CitT-rel"/>
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        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="23"/>
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        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="471" mass="51496" checksum="777537E77AF84558" modified="2011-10-19" version="1">MLSEIKWKGFLLPLIFGIGLWLVTPLRPVAISIMAWHLFAIFVATIIACITKPLPMMAVTLIGIVVATLTGVFTMDEVATGFGNSTAWMVAMCMFMAAGFIKSGLGKRIAYLFVSLFGKRTLSLAYALSFVDAVLAIGIPSNNARVNGIMYPIIDNLSREMGSDPKQGTQRKLGSFLVFNEYEVNNITSGLFLTGLAGNMVAIGLAKMQGITVTWMQWFMAACVPGILSLLIIPWVLYKVYPPEVKQTPDAHRWATTRLAALGKMTASEKIMSITFILAIVLWLIGTKIGIDATEVSFIAVVILLITGVLTTNDLLNEHFAWNILVWLSIIMMMSKKLMTLGFFPWFSKTLGHLLNGMNWISVLIILFLAYFYLHYMFPSVSTQISALYAGFLSIAIGAGVPHVLAALLLAFAGSINLSTTPYSAGPAALLSSTGYVTSAEWWRLSAIIGVIFNVIWLGGGLLWTKLLGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3 4">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80051.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890565.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2991"/>
    <dbReference type="EnsemblBacteria" id="CCC80051">
        <property type="protein sequence ID" value="CCC80051"/>
        <property type="gene ID" value="lp_2991"/>
    </dbReference>
    <dbReference type="GeneID" id="57026322"/>
    <dbReference type="KEGG" id="lpl:lp_2991"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2496"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_2_9"/>
    <dbReference type="OMA" id="VICHENS"/>
    <dbReference type="PhylomeDB" id="F9USC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2546-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HTH_XRE"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="223" mass="25258" checksum="F8F8DEF6EA39FB5C" modified="2011-10-19" version="1">MNFSDNLKIIRQQKKMTQTDIATQLHVSRQTISSWENGRSYPDIGMLVQISMAYDFSVDQLLKGDLGMLKHYEAQSANNRRQQRLVAISYDLVVGLLFLSYLHYFLHWNDGIVTMVINGGLIVMTTTLIMNYNYFDDWATTKRQAWQLVGVITMLAVLNIALVWPQLASQIPSTQFLNQHAGAYLAGNVSGKLVGDFLHLFIWTAAAVMAIEIPLNRARKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH7</accession>
    <name>F9USH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004890621.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3058"/>
    <dbReference type="EnsemblBacteria" id="CCC80107">
        <property type="protein sequence ID" value="CCC80107"/>
        <property type="gene ID" value="lp_3058"/>
    </dbReference>
    <dbReference type="GeneID" id="57026376"/>
    <dbReference type="GeneID" id="66450633"/>
    <dbReference type="KEGG" id="lpl:lp_3058"/>
    <dbReference type="eggNOG" id="COG4633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131523_0_0_9"/>
    <dbReference type="OMA" id="HGKVIVK"/>
    <dbReference type="PhylomeDB" id="F9USH7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2600-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="13631" checksum="3849F72EE7F1F210" modified="2011-10-19" version="1">MMIKVLVLLIGGLAIGFILWWFFGKHATTTVTASAVDDLQQVDVEVKGGYSPEQIVLKKGVPAVLNFTRKDASGCLDHVVFSDFGINQELPQNQVEAITIDTSKSGEYQWACGMDMFHGKLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">DNA-binding ferritin-like protein, DPS family</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ordered locus">lp_3128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003587210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890682.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USN8"/>
    <dbReference type="STRING" id="220668.lp_3128"/>
    <dbReference type="EnsemblBacteria" id="CCC80168">
        <property type="protein sequence ID" value="CCC80168"/>
        <property type="gene ID" value="lp_3128"/>
    </dbReference>
    <dbReference type="GeneID" id="49611453"/>
    <dbReference type="GeneID" id="58402142"/>
    <dbReference type="GeneID" id="61187787"/>
    <dbReference type="KEGG" id="lpl:lp_3128"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2616"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_4_0_9"/>
    <dbReference type="OMA" id="LYLQTHN"/>
    <dbReference type="PhylomeDB" id="F9USN8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2661-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="DPS_DNA-bd_CS"/>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="18022" checksum="E6E7263A0C063C8D" modified="2011-10-19" version="1">MKYTKTKAVLNQLVADLSQMSMIIHQTHWYMRGPNFLKLHPLMDEFMEEIDSQLDVISERLIALDGSPYSTLKEMAENTKIQDWPGEWDKTTPERLAHLVDGYRYLEDLYQHGIEVSDVEKDFSTQDIFIGLKTAIEKKIWMIQAELGSAPEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP7</accession>
    <name>F9USP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, EIIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pts25B</name>
        <name evidence="3" type="ordered locus">lp_3137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642379.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890691.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3137"/>
    <dbReference type="EnsemblBacteria" id="CCC80177">
        <property type="protein sequence ID" value="CCC80177"/>
        <property type="gene ID" value="lp_3137"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3137"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2625"/>
    <dbReference type="eggNOG" id="COG3414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159248_0_1_9"/>
    <dbReference type="OMA" id="MNMADIV"/>
    <dbReference type="PhylomeDB" id="F9USP7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2670-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="10797" checksum="75C901360A7A4CE3" modified="2011-10-19" version="1">MKTLAAVCSTGLGSSFMVDMNMADIVKGLGLEDRVKTTHMDMGSANENSADHFFVGKDLADAAKDRLGIDKVTVLDSIIDKEELKTKVTTYLKDAGIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV3</accession>
    <name>F9USV3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="220668.lp_0131"/>
    <dbReference type="EnsemblBacteria" id="CCC77684">
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        <property type="gene ID" value="lp_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0131"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="KQGEKFM"/>
    <dbReference type="PhylomeDB" id="F9USV3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-106-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04397">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="HTH_LYTTR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="19286" checksum="9F5CEF9E46CD3458" modified="2011-10-19" version="1">MSSRIFTTISLSKSLFKGESTRHVQLTISETIHQVFVTIHGPQLTPTIKELQRNIEALTNQQFINVFQDRSLIKLPLQSVSRFYTANKRLYCETTTGAYLVHSHLHTLMDQLPPHQFLRISSSEIVRIACVKNFTLTKWGSFQVNLTTGTTTYASRRYTQQIRKAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
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    <name>F9USW8_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Transcription regulator, PadR family</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888213.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0154"/>
    <dbReference type="EnsemblBacteria" id="CCC77699">
        <property type="protein sequence ID" value="CCC77699"/>
        <property type="gene ID" value="lp_0154"/>
    </dbReference>
    <dbReference type="GeneID" id="57026986"/>
    <dbReference type="GeneID" id="66448282"/>
    <dbReference type="KEGG" id="lpl:lp_0154"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.124"/>
    <dbReference type="eggNOG" id="COG1695">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_4_1_9"/>
    <dbReference type="OMA" id="HGYALIQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-121-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="91"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12273" checksum="89862C056D4B6478" modified="2011-10-19" version="1">MPANFYQRLIDKYEPMTEAAFLVLVSVRQPITSEAIPAKIAEMTNNQLQLGLGTLFTNLHAMTKDYLMTERVDENDVHTYEITGSGESVLAAERKRLQLLNQICEQAGL</sequence>
</entry>
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    <accession>F9UT22</accession>
    <name>F9UT22_LACPL</name>
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        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0217</name>
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    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0217"/>
    <dbReference type="EnsemblBacteria" id="CCC77753">
        <property type="protein sequence ID" value="CCC77753"/>
        <property type="gene ID" value="lp_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0217"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.180"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_6_2_9"/>
    <dbReference type="PhylomeDB" id="F9UT22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-175-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
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        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="24801" checksum="572DEBD476FF5805" modified="2011-10-19" version="1">MNPSMKLLLLLIIALEISFTTIVSLNVALIILALIYLLGHRTRLRTLGWLLLIPLLPAIGLWSTQYINGSGDKTLMAWVLFTRIYAFVFTGATFTLTTDVLQLTDSLEQNWHLPAKFAYGVLAAYNLVPRIQHEVQVIRAAGLMRGQVLSFWSPQLYFKAILVSINWSQNLARAMRSHGFVEDAPRTHYRQIPLTKLDWTIVISGVLLLQVGAFVIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT39</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    <sequence length="184" mass="20704" checksum="A6D141D5D866D22D" modified="2011-10-19" version="1">MKKLIWALRVGIVLFGACLVWEQVQLERHTSQRRTYHQRRLQRSTAATFKAIRQPQLSDFPAAKVEAAQVWLHLKGTRVINEATPLHIRKIAAGQRIQPDDPHSAVYHHQMTQIYSDDLQDATNSVIYARNADNTVLVAHSRSGQRSQVGPVAQNVHTAMPAVQKMKIPAKPSATLLKVVQLII</sequence>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="CCC77800">
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            <fullName evidence="2">Hypothetical membrane protein</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80211.1"/>
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        <property type="gene ID" value="lp_3180"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2699-MON"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80211.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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    <accession>F9UTA1</accession>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1275 family</fullName>
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        <name evidence="2" type="ordered locus">lp_3192</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890733.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3192"/>
    <dbReference type="EnsemblBacteria" id="CCC80219">
        <property type="protein sequence ID" value="CCC80219"/>
        <property type="gene ID" value="lp_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3192"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2667"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079303_2_0_9"/>
    <dbReference type="OMA" id="MYYHSLV"/>
    <dbReference type="PhylomeDB" id="F9UTA1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2707-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="25109" checksum="7800D69FAEA047CC" modified="2011-10-19" version="1">MQRFQSRHLFQLREIGLGLTCIGGFIDAYTFIQRGGVLAAGQTGNLIFLSVDVAQWNLPGVLTKLATVLFFTLGVIVVGILKQWLGARSHYWRLPVLVAELVVCLMVGMLPATVSNAMVVPPLAFVMAMQTTAFSAIAGHGYNNVFSTGNLKKATIALTNYWLTGVRTELDTGLVYWELVLSFATGAIVSAILQRWWTLRTIWVAAGLSILVGGYYTWLLVHRTANDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD9</accession>
    <name>F9UTD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, TMR-like</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890771.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3239"/>
    <dbReference type="EnsemblBacteria" id="CCC80257">
        <property type="protein sequence ID" value="CCC80257"/>
        <property type="gene ID" value="lp_3239"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3239"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2705"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_7_9"/>
    <dbReference type="OMA" id="RDYTWHQ"/>
    <dbReference type="PhylomeDB" id="F9UTD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2745-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="31816" checksum="49CA771E0EE2A684" modified="2011-10-19" version="1">MKYAITGATGHLGQQIVAAMRPLVATTELYLGVHTLSKAQVYQQQGLHIAAIDYQQPEQLRAFFQDSDVLIYIPSKSHDSYSRVQEFENVLAAVQQANVHHFLVMGFIADQVNNPFALSAFYGYVPRRLAGSDINYTIVRNALYADPLVPYLPELIERHNVVYPMADQALSFISQADSAAAFAKVATTPDLLQRGRIYTLTQSRAYTMPELATVLSQVSGQLIGYRPVSLQAFSNMYNQNGEGPMLASMYAGGARGLLATVSDDYQLIMDRPAQSLLDYLQTNYQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE5</accession>
    <name>F9UTE5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890777.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80263">
        <property type="protein sequence ID" value="CCC80263"/>
        <property type="gene ID" value="lp_3246"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3246"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2711"/>
    <dbReference type="eggNOG" id="ENOG5030A5E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324992_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2751-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="199" mass="22160" checksum="A5FBB920A301F477" modified="2011-10-19" version="1">MTQLIVPALPVERVQYERAYVLGLEAMMKVIRQLTTTEKGRQVPTNQFPVFAASYDVPQALAQVAVLKAATTRLKVRPIQLTVTRQYVTLRFQLQAAAGQPVWVPSAGALWRLYDGFLSNLVGIPFQHLANIQIGLQRVTGPLTVTTPIRPSFQNYDVRLTPSGQTGCLVKVHKAPAILARRAPIYQLSHYSETIRPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG0</accession>
    <name>F9UTG0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione reductase</fullName>
            <ecNumber evidence="7">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gshR4</name>
        <name evidence="7" type="ordered locus">lp_3267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890792.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3267"/>
    <dbReference type="EnsemblBacteria" id="CCC80278">
        <property type="protein sequence ID" value="CCC80278"/>
        <property type="gene ID" value="lp_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3267"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2727"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_0_9"/>
    <dbReference type="OMA" id="VEHIWAM"/>
    <dbReference type="PhylomeDB" id="F9UTG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2766-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="5">
        <location>
            <begin position="338"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="444" mass="48259" checksum="190BB0ED9FE55EEA" modified="2011-10-19" version="1">MTNKYDYDVLYIGAGHATFDGAAPLAKTGVRVGVIESGLIGGTCPNRGCNAKITLDEPVKLTRETARLNDILSSAPTINWTANVAHKQEIIDPLPAGLTARLEDGGATIIHGHATFKDAHTVVVDDQQTITAEKIVIATGLKPHRLDIPGTKLAHDSSDFMNLKRLPQSIVIIGAGYIGMEFATIANAAGAQVTVMLHGDQALRDFYQPFVAQVVDDLTERGVTFIKNANVQAFTKQDDQFQVSYGDHQQLTTDWILDATGRIPNLDGLGLDRIGVKYDRHGVYVNDHLQTNVPNIYAAGDVLANDLPKVTPAAYFESKYLMRLFSGQTSAPIDYPVIPSVVFTSPRIAQAGMKIPAAEKAGLTVSDNDLADYWYYQVSKEPIAASKQVHDQDGHLVGVTEISDQAEDAVNALLPAIEYQLDREQIDRLIGIFPTIGYAAWHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM9</accession>
    <name>F9UTM9_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Drug/metabolite transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80347">
        <property type="protein sequence ID" value="CCC80347"/>
        <property type="gene ID" value="lp_3358"/>
    </dbReference>
    <dbReference type="GeneID" id="57026610"/>
    <dbReference type="KEGG" id="lpl:lp_3358"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2800"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_9"/>
    <dbReference type="OMA" id="QDRFSWT"/>
    <dbReference type="PhylomeDB" id="F9UTM9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2836-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="32748" checksum="F666303C7465E4E6" modified="2011-10-19" version="1">MTTNRYMKGIMWAMLASTLWGVSGTVMQFVSQNQAIPADWFLSVRTLSAGIILLAIGFVQQGTKIFKVFRSWASVGQLVAYATVGLMANMYTFYISIERGTAAAATILQYLSPLFIVLGTLLFKRELPLRTDLIAFAVSLLGVFLAITKGNIHELAIPMDALVWGILSGVTAALYVVLPRKIVAENSPVVILGWGTLIAGILFNLYHPIWIGAPKITPTLVTSIGAIVLIGTIFAFLSLLHSLQYAPSAVVSIVDAVQPVVTFVLSIIFLGLQVTWVEILGSLLVIVAIYILQQYRSDPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN1</accession>
    <name>F9UTN1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0274"/>
    <dbReference type="DNASU" id="1061172"/>
    <dbReference type="EnsemblBacteria" id="CCC77801">
        <property type="protein sequence ID" value="CCC77801"/>
        <property type="gene ID" value="lp_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="57027088"/>
    <dbReference type="GeneID" id="66448370"/>
    <dbReference type="KEGG" id="lpl:lp_0274"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.228"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_3_9"/>
    <dbReference type="OMA" id="ITEFIHE"/>
    <dbReference type="PhylomeDB" id="F9UTN1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-223-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="25407" checksum="4FDB32A2DF9BE87F" modified="2011-10-19" version="1">MSEIETIQAYYAASLGKDGRITRTQRQILAAALDLFAEKGYEEVGTREIAERAGVAEGTLFHNFVNKNGILDAIMQPIVQNILPTMLNTLDQAVLDSPNQTLQAFVVALVRDRVAFVTRNRASLAVILSQFFNNAQDRAAVLGMVSPSILAQANEAMDRLKAARELVDWPNRMILQLVFSTIGGYLVEQVLYPQLDDLSDEQLIHYLSDFLVNGLSPRRIPLQDDNTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP5</accession>
    <name>F9UTP5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional attenuator, cell envelope-related, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888329.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0290"/>
    <dbReference type="DNASU" id="1061154"/>
    <dbReference type="EnsemblBacteria" id="CCC77815">
        <property type="protein sequence ID" value="CCC77815"/>
        <property type="gene ID" value="lp_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0290"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.243"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_2_0_9"/>
    <dbReference type="OMA" id="FSYDWCD"/>
    <dbReference type="PhylomeDB" id="F9UTP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-237-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="76"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="343" mass="37692" checksum="B7EA267027717982" modified="2011-10-19" version="1">MRHSASSKLRPVLIAVGIIIVIAFVAIGLIIRQAQARYQSTIYTGNSSTKIDTTKPLSILLLGVDTGADGRIDKGNSDTIMVVTINPQTKKTLITSIPRDSLAEMVGDQDTNVQKLNAAYNIGGSKMAKASVSKLFNVPIDYYATINMGGLKQIVDAVGGVTITSPLNVSFDHITVTKGKHHLNGKQALSYTRMRYQDPRGDYGRQLRQQQVMRAVLAKLAETKTYSRYNQLLTSLKGNLQTDLSFNDLVGLATHDRANMKHIQSTQVIGSPAWINTSSYQILSTKTLQQTSDRLRTQLGLSTETLTNMETKLNAKNTVYDGKTNLNYDTQGLDKITYSDNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS3</accession>
    <name>F9UTS3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, spermidine/putrescine transport operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888357.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0319"/>
    <dbReference type="DNASU" id="1062146"/>
    <dbReference type="EnsemblBacteria" id="CCC77843">
        <property type="protein sequence ID" value="CCC77843"/>
        <property type="gene ID" value="lp_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0319"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.271"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_4_9"/>
    <dbReference type="OMA" id="YDSVVPH"/>
    <dbReference type="PhylomeDB" id="F9UTS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-265-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="180" mass="20040" checksum="E76D63F9780E516E" modified="2011-10-19" version="1">MDIGQRIRNLRIQKQLTQEELGERTDLSKGYISQLEHNQSSPSMETFFAILEVLGCAPADFFAAEQPTHKVVYHPADQTTYDDEALGYRVKWLVPASNENQLEPVTVTLAPSGRFKSFEPSPAETFIMVQTGTLSLQLGAQQYTATAGDTLYFHATKTHQIRNLGTTSCTFTLVTTASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV1</accession>
    <name>F9UTV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular zinc metalloproteinase, M10 family</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">zmp1</name>
        <name evidence="7" type="ordered locus">lp_0353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77871">
        <property type="protein sequence ID" value="CCC77871"/>
        <property type="gene ID" value="lp_0353"/>
    </dbReference>
    <dbReference type="GeneID" id="57027162"/>
    <dbReference type="KEGG" id="lpl:lp_0353"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.298"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100551_0_0_9"/>
    <dbReference type="OMA" id="YYLENDY"/>
    <dbReference type="PhylomeDB" id="F9UTV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-293-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394429" evidence="5">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ZnMc" evidence="6">
        <location>
            <begin position="36"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="20974" checksum="67FAC19B9D1FDDD1" modified="2011-10-19" version="1">MKNKYSAKLGLTTLTVIFGLGLTPIANAKSIATPYSRSRWPHAQVTYVIQASSYERHVYQAAIQAWNATGHFKFVPGTTAHHQITLGTSNATSGQYYRLAGITFSTGYTNGYYTKAQVYLLTRNFVRYHYSYTDQVHVAEHELGHTIGLEHSRDRHSVMLADNRYNGISAADSAAVRLRYRLPVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU18</accession>
    <name>F9UU18_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888452.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0432"/>
    <dbReference type="EnsemblBacteria" id="CCC77938">
        <property type="protein sequence ID" value="CCC77938"/>
        <property type="gene ID" value="lp_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0432"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.352"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_4_1_9"/>
    <dbReference type="OMA" id="YMQNIVA"/>
    <dbReference type="PhylomeDB" id="F9UU18"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-359-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="769" mass="87815" checksum="CFEB48883683CC3D" modified="2011-10-19" version="1">MATSDQEQQREQQRVDRVIEQVKERAQQTDDLLAKAHHETDVIQKNYGDNNSVNTFEVDDRIETNAELQQQKQMVERAVESEAILKRQVGVLKDLSNSPYFGRIDIQDSPDEEAERLYIGTASFVDAEQNFLVYDWRAPISSVYYNGTLGQVQYQTPAGQQTTELIKKRQFQINHGQIKNMFDTNETVGDEILQAVLGEQNDAYMQNIVATIQKEQNDIIRDTTSDLLVVQGVAGSGKTSAILQRIAFLLYHSRASLEADQMVLFSPNRLFSHYISEVLPSLGERNMRQVTLAEFLSARFQGLTVESLFERYESDRQREQLTPAIRDFQESADFMRQVDQYCHQLPADQLRFTNIVFNGEIFFAKEVITKIAAALPAAMQPADRFLAIKNTLIKRLKHRIDDEAQADWVNDIIDQLSDEAYHDLLGSKRRGDFQSLDDEVFYIGKQIVTKRLRQVYDAIYNGYFLDTYEQYNDFLAQVDRPTTVTPDQWQQRIAAYQAAVEYHRIALVDCAPLLLLRDVLTGSGQNRRMQYIFVDEMQDYSLAQLLYIKHAFPLAKFTLLGDSEQALFKGIELPQQLLERLKDAFNVRRANLITLNKSYRSTEQITNFAKALLPDGDQIQAFTRKGDLPKVMIRYGEDAALSSLRSEVEHQLKATNTVAVLTKDLAESKQVYQYLKRYTVTTLMADSDRTMPQGVIVMPIYLAKGLEFDAVVAYDVSATNYPDADSVGILYTIASRAMHHLTLLSIGDVSPLIAQLDPTLFTIEHQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU48</accession>
    <name>F9UU48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin V acylase family protein</fullName>
            <ecNumber evidence="4">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pva2</name>
        <name evidence="4" type="ordered locus">lp_3362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890864.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU48"/>
    <dbReference type="STRING" id="220668.lp_3362"/>
    <dbReference type="MEROPS" id="C59.001"/>
    <dbReference type="EnsemblBacteria" id="CCC80350">
        <property type="protein sequence ID" value="CCC80350"/>
        <property type="gene ID" value="lp_3362"/>
    </dbReference>
    <dbReference type="GeneID" id="66450877"/>
    <dbReference type="KEGG" id="lpl:lp_3362"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2803"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_0_9"/>
    <dbReference type="OMA" id="MCTRLVY"/>
    <dbReference type="PhylomeDB" id="F9UU48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2839-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="328" mass="36167" checksum="09D2B9618A937229" modified="2011-12-14" version="1">MCTSLTIQTTAGDQFLARTMDFAFELGGRPVAIPRNHHFDSVTNADGFDSPYSFVGTGRDLNGYIFVDGVNEHGVSAAALYFSGQAHFTQQTKAGKVNLAPHEVLMWILGNVKSTAELGERIADLNVMEAAAPLLNIVVPLHWIISDKSGSTYVLELENDGVHYMKNPVGVMTNTPDFEWHLKNLSNYVNLQPGPHPSRQYGDMTVNPFGPGTGALGMPGDYTSVARFVRTVFMREHTDAVTTDAEAVNALSHMLNSVEIPKGVKMQDNGTPDYTQYRAYMSMNEPAFYMQPYADQTITRVELTPALMTAAQPTEFELKTTQQFRLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA4</accession>
    <name>F9UUA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102157.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890920.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3426"/>
    <dbReference type="EnsemblBacteria" id="CCC80406">
        <property type="protein sequence ID" value="CCC80406"/>
        <property type="gene ID" value="lp_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3426"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2855"/>
    <dbReference type="eggNOG" id="COG4367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163224_1_0_9"/>
    <dbReference type="OMA" id="YHDYWFL"/>
    <dbReference type="PhylomeDB" id="F9UUA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2894-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018757">
        <property type="entry name" value="DUF2316"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10078">
        <property type="entry name" value="DUF2316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11558" checksum="1D990B59B4EEA5FC" modified="2011-10-19" version="1">MSLNAQQMQATRDELQANFALTGLTKAQVADDLAISATKLDHLFDLTQQSLNDPWILRNYLIEKVEAGGKTPVPFTALSGDWHRHWFLNSVVIDRREMSAGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC2</accession>
    <name>F9UUC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH oxidase</fullName>
            <ecNumber evidence="5">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nox5</name>
        <name evidence="5" type="ordered locus">lp_3449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890938.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3449"/>
    <dbReference type="EnsemblBacteria" id="CCC80424">
        <property type="protein sequence ID" value="CCC80424"/>
        <property type="gene ID" value="lp_3449"/>
    </dbReference>
    <dbReference type="GeneID" id="57026670"/>
    <dbReference type="GeneID" id="66450927"/>
    <dbReference type="KEGG" id="lpl:lp_3449"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2872"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_9"/>
    <dbReference type="OMA" id="LMTITWE"/>
    <dbReference type="PhylomeDB" id="F9UUC2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2912-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="333"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="49329" checksum="A078E587BB73CE48" modified="2011-12-14" version="1">MKVIVIGCTHAGTAAVNQILASNPDTEVTIYERNDNVSFLSCGIALYLGGQVADPQGLFYSSPEQLAKLGATVHMQHDVTDVNTDKHEITVTDLKTGESKTDHYDKLVVTTGSWPVIPPIDGIDSPNVYLCKNWTHAQNLWEAAKPAKRVIVIGGGYIGTELVEAYQKQGKEVTLIDGLPRILNKYLDKEFTDRVEQDFVDHGIKMALNQMVQGFSDDGKEVTVKTDKGSYTADMAILCVGFRPNTGLLKGKVDMNANGSIKTNDYMQTSDPDIYGAGDSVAVHYNPTKKDAYIPLATNAVRQGTLVGLNIFKPTRKYMGTQSTSGLMLFGQTIVSSGMTLEHAQAENVPAAAVTFEDNYRPEFMPTTKPVLMQLVYNPETREILGAQFMSEHDVSQSANVISVMIQNHNTIDDLGFVDMFFQPIYDRPFNYLNLLGQAAIAHAAEAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE8</accession>
    <name>Q6LWE8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">orf29</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222036.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133743.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723579"/>
    <dbReference type="EnsemblBacteria" id="CAG17860">
        <property type="protein sequence ID" value="CAG17860"/>
        <property type="gene ID" value="CAG17860"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17860"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3107"/>
    <dbReference type="eggNOG" id="ENOG5030GAH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111056_0_0_9"/>
    <dbReference type="OMA" id="TYQNNKD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3160-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004276285" evidence="2">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="205" mass="23149" checksum="892411EBDB8AA26C" modified="2004-07-05" version="1">MKRSVVLSIAIGSLILVMSLGANAYQHSQIKQAQQQISRLQQQKRQVSRQLTKTNQQKQLLSAQIDSYKTYQNNKDKSQAELSFNTVVTKFFEVMNNFKPKTYGQRKDGVKGLISDKLYQQYFSNKGTYGDSNSVSAKLNQLNLYTQSKQGQNMKGLAVISYESKSGDNDWQKATVLYQVTFDTTTDRITAIQNLGSSFKASDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF4</accession>
    <name>Q6LWF4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf23</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222030.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133737.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723573"/>
    <dbReference type="EnsemblBacteria" id="CAG17854">
        <property type="protein sequence ID" value="CAG17854"/>
        <property type="gene ID" value="CAG17854"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17854"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3101"/>
    <dbReference type="eggNOG" id="ENOG50309VH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155172_0_0_9"/>
    <dbReference type="OMA" id="FRWSAYA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3154-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="16374" checksum="47D1CA9BB7B2083E" modified="2004-07-05" version="1">MKKIWHWLLKKIKKDMQTDPFTIPPRRTKLSYYFDSFASIIFYLMGLYLMLIDLYHELFTSDKTDFVGTALMAFILIFGGLLFRWSAYADIKAINRYRQYLKQQSIDQQQELCRETWLKASEQGKTELEQKLNHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG1</accession>
    <name>Q6LWG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH oxidase (Putative)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nox</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222024.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133730.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723566"/>
    <dbReference type="PeroxiBase" id="5454">
        <property type="entry name" value="LplNadOxd00"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17847">
        <property type="protein sequence ID" value="CAG17847"/>
        <property type="gene ID" value="CAG17847"/>
    </dbReference>
    <dbReference type="GeneID" id="57295603"/>
    <dbReference type="KEGG" id="lpl:CAG17847"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3094"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_9"/>
    <dbReference type="OMA" id="SPWDPVQ"/>
    <dbReference type="PhylomeDB" id="Q6LWG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3147-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG17847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="50595" checksum="3ED0D92207BF36B9" modified="2004-07-05" version="1">MANETEKLLIIGGSDAGISAALKAKELKPELKVQILLADEYPNLSICGIPYAVSGEVPDWHLLAHRNLQELTSTGIEFQMNMIADKIEPQRHEVVAHALTGELKTYHYDHLVVATGARPKLSGIKGVDLAQAQQQDSKVRILHTMADYFAIERNIATDSVRKVAIVGSGYIGIEMAEALRKRHLDVTIFQRGSEILSTVDADLGRIIHQKLSANAVNVITGLTVSEINETGSNVEVVGLNEHQKTQSSTYDLVLIVVGVQPNNELLVKVGAETGIAGAIEVDQYMQTSLPDIWAAGDLVETRHHLLGETYLPLGTTAHKQGRIAGFNIAGIQRAFKGSLGTQVLKAFDLVVVRTGLLTSEAIQAGFNPFTVTTDVDDHKAYFPGAQKIKIRITGDQKSGRLLGVQLIGHYGSEVAKRSDIFATAIFNDMTVAEISDLDLSYSPPVGSPWDAVQIAAQNWEQQNAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH7</accession>
    <name>Q6LWH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copy-number control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS102</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377165">
        <property type="protein sequence ID" value="CAG17831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222011.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133711.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17831">
        <property type="protein sequence ID" value="CAG17831"/>
        <property type="gene ID" value="CAG17831"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17831"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3128-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS102"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="52" mass="6020" checksum="BE2967E34351310F" modified="2004-07-05" version="1">MAENKKRVSIGLTDKQYELVQKLAKEKGFSKSAIFVLALEEYSRKESEQKNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VZ6</accession>
    <accession>F9UPK9</accession>
    <name>DER_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">lp_1881</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640588.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889662.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VZ6"/>
    <dbReference type="SMR" id="Q88VZ6"/>
    <dbReference type="STRING" id="220668.lp_1881"/>
    <dbReference type="EnsemblBacteria" id="CCC79148">
        <property type="protein sequence ID" value="CCC79148"/>
        <property type="gene ID" value="lp_1881"/>
    </dbReference>
    <dbReference type="GeneID" id="57025474"/>
    <dbReference type="GeneID" id="66449706"/>
    <dbReference type="KEGG" id="lpl:lp_1881"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1584"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_9"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="PhylomeDB" id="Q88VZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1610-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000179004" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="175"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="436" mass="48777" checksum="9835CFD713AEFFC7" modified="2003-06-01" version="1">MAKPVVAIVGRPNVGKSTIFNRIAGDRISIVEDTPGVTRDRIYANSEWLGQEFSLIDTGGIDIEDAPFIKQITQQAEIAIDEADVIIYLVSIKEGVTDADEHVAQILYRSNKPVVLGVNKVDNPELRSEVYDFYSLGFGDPYPISGAHGLGLGDLLDAVIKNFPEKSGEDEPGTIRFSLIGRPNVGKSSIVNALLGEDRVIVSDVAGTTRDAIDTKFTDQDGDRFVMVDTAGIRKKGKVYENTERYSVMRALKAIDNSDVALFVINGEEGIREQDKRVAGYAHEAGKGIIIVVNKWDLVKKDNHTMQEFEAYIRDQFVYLSYAPIIFVSAKTNQRLEQLPALIKKVNTNHMRRIQSSVLNDVIMDAIAMNPTPSDNGKRLRVYYATQVAIQPPTFVVFVNDPDMMHFSYERFLENQIRNAFDFSGTPIHMIERRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W25</accession>
    <accession>F9UPI0</accession>
    <name>HSLV_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="1">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslV</name>
        <name type="ordered locus">lp_1846</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638820.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889633.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W25"/>
    <dbReference type="SMR" id="Q88W25"/>
    <dbReference type="STRING" id="220668.lp_1846"/>
    <dbReference type="MEROPS" id="T01.007"/>
    <dbReference type="PRIDE" id="Q88W25"/>
    <dbReference type="EnsemblBacteria" id="CCC79119">
        <property type="protein sequence ID" value="CCC79119"/>
        <property type="gene ID" value="lp_1846"/>
    </dbReference>
    <dbReference type="GeneID" id="49394082"/>
    <dbReference type="GeneID" id="57025433"/>
    <dbReference type="KEGG" id="lpl:lp_1846"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1556"/>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093872_1_1_9"/>
    <dbReference type="OMA" id="IMKGNAR"/>
    <dbReference type="PhylomeDB" id="Q88W25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1582-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="chain" id="PRO_0000148116" description="ATP-dependent protease subunit HslV">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <sequence length="180" mass="19403" checksum="6FF2140A52386429" modified="2003-06-01" version="1">MTTKFEATTICAVRQNGHNAMAGDGQVTMGEKVVMKGTAHKVRRIYNDQVVVGFAGSVADAFNLEDRFEKKLNEFSGNLQRAAVELAQEWRSDQALQKLEALLIVMNKDDMLLVSGSGEVITPDNDVLAIGSGGNFALAAARAMQLHAKDMSAKEVAEAAIHIAGDIDIFTNHNVISETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W96</accession>
    <accession>F9UPA7</accession>
    <name>Y1753_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0398 protein lp_1753</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1753</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0398 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889560.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W96"/>
    <dbReference type="SMR" id="Q88W96"/>
    <dbReference type="STRING" id="220668.lp_1753"/>
    <dbReference type="EnsemblBacteria" id="CCC79046">
        <property type="protein sequence ID" value="CCC79046"/>
        <property type="gene ID" value="lp_1753"/>
    </dbReference>
    <dbReference type="GeneID" id="57025374"/>
    <dbReference type="GeneID" id="66449609"/>
    <dbReference type="KEGG" id="lpl:lp_1753"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1479"/>
    <dbReference type="eggNOG" id="COG4474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105319_0_0_9"/>
    <dbReference type="OMA" id="LEWVITG"/>
    <dbReference type="PhylomeDB" id="Q88W96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1509-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01575">
        <property type="entry name" value="UPF0398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021290">
        <property type="entry name" value="DUF1273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000267160" description="UPF0398 protein lp_1753">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01575"/>
        </source>
    </evidence>
    <sequence length="189" mass="21926" checksum="E200FA8CC87D3FF9" modified="2003-06-01" version="1">MSRLWLSGYRSYELNVFGDQDDKLKVIKFALTNYLTTQIEDGMDWLITGGQLGIEQWTAEVGLTLKKTYPELKVAMMLPYGEFGGRWNENNQAKLQTLLAQVDFHAPVSKQPYENPQQLKNYQEFMVTHTDAATLVYDPDNPGKPTYDYDLIRNFSDTHPYPLTLIDFDWLQESANEYAEKQNNGFNFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WZ5</accession>
    <accession>F9UNK3</accession>
    <name>MURC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">lp_1462</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101415.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889306.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WZ5"/>
    <dbReference type="SMR" id="Q88WZ5"/>
    <dbReference type="STRING" id="220668.lp_1462"/>
    <dbReference type="EnsemblBacteria" id="CCC78792">
        <property type="protein sequence ID" value="CCC78792"/>
        <property type="gene ID" value="lp_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1462"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1225"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_1_0_9"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="PhylomeDB" id="Q88WZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1253-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182107" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="436" mass="48751" checksum="25A582D850238CD4" modified="2003-06-01" version="1">MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDNIREGLTVIAGNSFTDDHPEIKKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTGLLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRHFVAYHPDYAIMTNVDFDHPDYYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRTTKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKRRFSEHQVGDMVMIDDYAHHPSEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAASLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEIITTDDMSALTAYHNAVAVFMGAGDIQKYEKIYEDQMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X36</accession>
    <accession>F9UNG2</accession>
    <name>ARGR1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Arginine regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">argR1</name>
        <name type="ordered locus">lp_1411</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates the transcription of the arc operon, involved in arginine catabolism.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; L-arginine degradation via ADI pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X36"/>
    <dbReference type="SMR" id="Q88X36"/>
    <dbReference type="STRING" id="220668.lp_1411"/>
    <dbReference type="EnsemblBacteria" id="CCC78751">
        <property type="protein sequence ID" value="CCC78751"/>
        <property type="gene ID" value="lp_1411"/>
    </dbReference>
    <dbReference type="GeneID" id="57025043"/>
    <dbReference type="KEGG" id="lpl:lp_1411"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1183"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097103_3_0_9"/>
    <dbReference type="OMA" id="MVYCLPP"/>
    <dbReference type="PhylomeDB" id="Q88X36"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1212-MON"/>
    <dbReference type="UniPathway" id="UPA00254"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000205095" description="Arginine regulator">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="153" mass="17126" checksum="E8F4A3F58E242CC8" modified="2003-06-01" version="1">MKKSERQAVIEQLISEYPIATQEELMAKLKAEGIAATQATISRDIREMQIVKTPDEHGQTRYAIFKTTNKNEQDRLFETLHDVVTSIDRVEFMNIIHTLPSNGNLLAAIIDDLNLPEVSGTLAGHDTIFVVSPNTTVAKQLYESFASHISNED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X61</accession>
    <accession>F9UND7</accession>
    <name>SAT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sat</name>
        <name type="ordered locus">lp_1378</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101379.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X61"/>
    <dbReference type="SMR" id="Q88X61"/>
    <dbReference type="STRING" id="220668.lp_1378"/>
    <dbReference type="EnsemblBacteria" id="CCC78726">
        <property type="protein sequence ID" value="CCC78726"/>
        <property type="gene ID" value="lp_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1378"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1157"/>
    <dbReference type="eggNOG" id="COG2046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_9"/>
    <dbReference type="OMA" id="LQHMIIR"/>
    <dbReference type="PhylomeDB" id="Q88X61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1186-MON"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000340624" description="Sulfate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <sequence length="391" mass="43855" checksum="B8F28652AF86AB60" modified="2003-06-01" version="1">MQTVYGIKAHGGKLVNLEDFSEATRQAAEQLPSLTINNWNISDLELIGIGGFSPLTGFMVSDDYHSVVNTMHLKSGVIWSVPITLGVSQADADKIELNTKIALKGADGVIYGTMQVEDKFVPDKQLEAQNVYKTTDEAHPGVKRLYANGDVYLGGAIKLLHKPDHGAFSDYYMEPLETRKMFHDLGWKRIVGFQTRNPIHRAHEYIQKLALENVDGLFLNPLVGETKADDIPADVRMESYKTILKYYYPEDRVRLVIYPAAMRYAGPKEAILHAIVRKNYGCTDFIVGRDHAGVGDYYGTYEAQELITSVEDEMGMHFFKFDNSFYCKKCGSMATQKTCPHGAEDHISLSGTKVRKMLADGVVPPKEVSRPEVARVLIDGLKRKREQQQEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XU8</accession>
    <accession>F9UMP4</accession>
    <name>RL13_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">lp_1077</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638098.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888997.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XU8"/>
    <dbReference type="SMR" id="Q88XU8"/>
    <dbReference type="STRING" id="220668.lp_1077"/>
    <dbReference type="EnsemblBacteria" id="CCC78483">
        <property type="protein sequence ID" value="CCC78483"/>
        <property type="gene ID" value="lp_1077"/>
    </dbReference>
    <dbReference type="GeneID" id="49393355"/>
    <dbReference type="GeneID" id="57024729"/>
    <dbReference type="GeneID" id="66448985"/>
    <dbReference type="KEGG" id="lpl:lp_1077"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.912"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_1_9"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="PhylomeDB" id="Q88XU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-926-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000261736" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="147" mass="16169" checksum="E2EF99C255F1A00B" modified="2003-06-01" version="1">MRTTYMAKPGEIDRKWYVVDATDVPLGRLSTVVASILRGKNKPTFTPNVDTGDNVIVINASKVALTGKKAERKIYYHHTAYAGGLKERTAGDFLAKEPTKLIETSVKGMLPHNSLGHKMGLKLHVYAGAEHTQQAQKPEVLDITNLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW7</accession>
    <accession>F9UMM4</accession>
    <name>RL15_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">lp_1055</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW7"/>
    <dbReference type="SMR" id="Q88XW7"/>
    <dbReference type="STRING" id="220668.lp_1055"/>
    <dbReference type="EnsemblBacteria" id="CCC78463">
        <property type="protein sequence ID" value="CCC78463"/>
        <property type="gene ID" value="lp_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="49393336"/>
    <dbReference type="GeneID" id="57024710"/>
    <dbReference type="GeneID" id="66448966"/>
    <dbReference type="KEGG" id="lpl:lp_1055"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.890"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_9"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="PhylomeDB" id="Q88XW7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-906-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104737" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="143" mass="15345" checksum="003103681E0B160E" modified="2003-06-01" version="1">MKLHELTPSEGSRFSRRRIGRGDSSGQGKTSGRGQKGQKARGKVRVGFEGGQMPLYRRIPKRGFTNINRKEYAVVNLDGLNRFDDGAEVTPESLKEAGLVKKSSAVKVLGNGKLNKKLTVKASKFSATAVAAIEAAGGKTEVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY9</accession>
    <accession>F9UMK2</accession>
    <name>RS7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">lp_1026</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638057.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888955.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY9"/>
    <dbReference type="SMR" id="Q88XY9"/>
    <dbReference type="STRING" id="220668.lp_1026"/>
    <dbReference type="PRIDE" id="Q88XY9"/>
    <dbReference type="EnsemblBacteria" id="CCC78441">
        <property type="protein sequence ID" value="CCC78441"/>
        <property type="gene ID" value="lp_1026"/>
    </dbReference>
    <dbReference type="GeneID" id="49393314"/>
    <dbReference type="GeneID" id="57024688"/>
    <dbReference type="GeneID" id="66448942"/>
    <dbReference type="KEGG" id="lpl:lp_1026"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.867"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_9"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="PhylomeDB" id="Q88XY9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-884-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124278" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17841" checksum="B88D1F4F24F3CE02" modified="2003-06-01" version="1">MPRKGAPAKREVLADPMYNSKLVTRLINHLMLDGKRGTASTILYDAFDQIKEQTGNDPLEVFEEAMKNVMPVLEVKARRVGGSNYQVPIEVRPDRKTTLGLRWIVQYARSRGEHTMSDRLAREIMDAANNTGASVKKREDTHRMAEANRAFAHYRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XZ3</accession>
    <accession>F9UMJ8</accession>
    <name>RPOB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">lp_1021</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888951.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XZ3"/>
    <dbReference type="SMR" id="Q88XZ3"/>
    <dbReference type="STRING" id="220668.lp_1021"/>
    <dbReference type="EnsemblBacteria" id="CCC78437">
        <property type="protein sequence ID" value="CCC78437"/>
        <property type="gene ID" value="lp_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1021"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.863"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_9"/>
    <dbReference type="PhylomeDB" id="Q88XZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-880-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000047908" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134502" checksum="9BA8E9F6AD987BD2" modified="2011-11-16" version="2">MAGHLVKYGKHRTRRSYARIKEVLDLPNLIEIQTDSYQWFLDEGLREMFEDIMPIDDFAGKLSLEFVDYQLLEPKYTVEEAREHDANYSAPLHVTLRLTNHETGEIKSQDVFFGDFPLMTEQGTFIINGAERVIVSQLVRSPGVYFNEELDKNGRPSYGTTVIPNRGAWLELETDAKNVSYVRIDRTRKIPLTELVRALGYGSDDDIIDMLGETDSLMLTLEKDVHKNTDDSRVEESLKDIYERLRPGEPKTADSSRSLLTARFFDPKRYDFAPVGRYKVNKKLSMKTRLMDQTLAETLADPDTGEVIAQKDTVIDKNVMAKLSPYLERDDFKTVTYTPSDEAVVTNPMVLQVVKVYSQNDPEKVVNVIGNGNIDLKFKHIVPADIIASINYFFNLQEGLGSTDDIDHLGNRRIRSVGELLQNQFRIGLSRMERVVRERMSIQDAATVTPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINSLSSYAKVNRSGFIETPYRRVDWTTHKVTDKIDYLAADEEDQFVIAQANSPLNDDGSFVEDTVLARNKEENLETPIENVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLLDPHAPLIGTGIEYKAAHDSGIALICRHEGTVEYVDAREVRVRRDDGSLDTYKLMKFRRSNGGKNYNQRPIVKVGDHVDNDEVLADGPAMEGGELALGQNPLVAFMTWNGYNFEDAIIINERLVREDVYTSIHIEEYESEARDTKLGPEEMTREIPNVGEDALKNLDEDGIIRIGAEVKDGDILVGKVTPKGVTELSAEERLLHAIFGEKAREVRDTSLRVPHGGGGIIQDVKIFTRENGDELSPGVNMMVRVYIAQKRKIQVGDKMAGRHGNKGTVSIVVPEEDMPYMPDGTPIDIMLSPMGVPSRMNIGQVLELHLGMAARKLGIHMATPVFDGAQDTDIWEAIREAGVDSDAKSIVYDGRTGEPFDKRVAVGVMHYMKLSHMVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDVVGRVKTYEAIVKGEPIPKPGVPESFRVLVKELQALGLDMKVLDSEDKEIELRDMDDDDDEVVNVDALSKFKQQQDEKAADKAAKADAAKPSETTNAQQDNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z33</accession>
    <accession>F9UL18</accession>
    <name>TILS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">lp_0545</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888547.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z33"/>
    <dbReference type="SMR" id="Q88Z33"/>
    <dbReference type="STRING" id="220668.lp_0545"/>
    <dbReference type="EnsemblBacteria" id="CCC78033">
        <property type="protein sequence ID" value="CCC78033"/>
        <property type="gene ID" value="lp_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0545"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.451"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_2_9"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="PhylomeDB" id="Q88Z33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-454-MON"/>
    <dbReference type="BRENDA" id="6.3.4.19">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000181709" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="448" mass="51018" checksum="59E1ABC7B0589699" modified="2003-06-01" version="1">MTPIQKFNRQLAAAKLLSPQQTVVVAVSTGVDSMVLLHLLQRLPAAERPRVVVAHVNHHLREQSQMEADYLRQYCQQQNLKLVMADWLPAAHPKSGIEAAGRQFRYHVFAKVMRENRATAVLTAHHANDQVETYLMKLARGGDISQLTGIATSRPFATGRLIRPLLTWSKDQLRNYAAEQHVVYFEDVTNQDVALTRNRIRHRVVPELMTVNPQLLKHVADYQQQLTTLLTAKKQMVTVLLSQVVTATGALVVDQWGALPSQWQLAVFATWLEQQTQQLFTESKLQPLVSWGQRTRPATSRLTVNAAWELYRNAGIIEALPIKKRGKKLMPREKIMVDLNQWQKITATQTVGIFTRVPNVVSQPFWLTEADWPLVWRPWQAGDRIVLKGGGHQLVRRLLIDRKVPAERREQVQVLVNAQGNVLWVVGHKFSYRTTGTQTVFLALKHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZC3</accession>
    <name>Q88ZC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component response regulator PlnD,repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">plnD</name>
        <name evidence="6" type="ordered locus">lp_0418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641982.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888439.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q88ZC3"/>
    <dbReference type="STRING" id="220668.lp_0418"/>
    <dbReference type="EnsemblBacteria" id="CCC77925">
        <property type="protein sequence ID" value="CCC77925"/>
        <property type="gene ID" value="lp_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0418"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.341"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="OMA" id="MNYYLLE"/>
    <dbReference type="PhylomeDB" id="Q88ZC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-347-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="28688" checksum="C701EF43376A375B" modified="2003-06-01" version="1">MFPIYLYEDNAEQRDNYCKTVNNTIMINEFAMELRVATDDQKIILADLNQQQDGLFFLDMEIGEDKQTGLELASRIRATIPLAKIVFITTHDELSFVTLERRIAPLDYILKDQSADLITQRIIKDINVVQNELKKTNSQRKDVFNYKLGTRYFSLALDDVILLSTSKLRPGSVQLHAINKVAEFPGNLNALEEKYPQFFRCDKSSLVNLNHLRSFDYKEKELLLDGEIRCKASFRKSRELNKLLRDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q890H4</accession>
    <accession>F9US67</accession>
    <name>RLMH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name type="ordered locus">lp_0045</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643636.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890H4"/>
    <dbReference type="SMR" id="Q890H4"/>
    <dbReference type="STRING" id="220668.lp_0045"/>
    <dbReference type="EnsemblBacteria" id="CCC77614">
        <property type="protein sequence ID" value="CCC77614"/>
        <property type="gene ID" value="lp_0045"/>
    </dbReference>
    <dbReference type="GeneID" id="66448193"/>
    <dbReference type="KEGG" id="lpl:lp_0045"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.36"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_0_0_9"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="PhylomeDB" id="Q890H4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-36-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000198134" description="Ribosomal RNA large subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <sequence length="159" mass="18109" checksum="053AB7F97FDDCCC2" modified="2003-06-20" version="1">MNIKIICVGKLKEKYFKQGIAEYAKRMSKFAKFQIVEVPDEKAPESLSNAEMENVKAKEGQRILEKIKDRDYVYALAILGKERSSEEFAAEIDKLTTYGHSDIDFVIGGSLGLSPEVLKRADTQISFGRFTLPHQLMRLVLSEQVYRAFMINVGSPYHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q890J8</accession>
    <accession>F9US43</accession>
    <name>RL9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">lp_0013</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641637.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888104.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890J8"/>
    <dbReference type="SMR" id="Q890J8"/>
    <dbReference type="STRING" id="220668.lp_0013"/>
    <dbReference type="EnsemblBacteria" id="CCC77590">
        <property type="protein sequence ID" value="CCC77590"/>
        <property type="gene ID" value="lp_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="57026874"/>
    <dbReference type="GeneID" id="66448168"/>
    <dbReference type="KEGG" id="lpl:lp_0013"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.11"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_2_9"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="PhylomeDB" id="Q890J8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-11-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176645" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="150" mass="16469" checksum="3B3AED3293B1CD32" modified="2003-06-01" version="1">MQVIFLNDVRGKGKRGQIKNVPDGYAQNFLIKKGLAKEATKAAINTLKAEQKSEAARAAEELAEAKQVKTVLEADETVVELKAKAGTDGRLFGSIPSKQIATALADQYQVKLDKRKIELPEPIRVLGYTNVPVKLHPEVTAKIRVHVVEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RLS9</accession>
    <accession>F9UL01</accession>
    <name>CARY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Carbamoyl-phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carB</name>
        <name type="ordered locus">lp_0526</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3416" last="3422">
            <title>In Lactobacillus plantarum, carbamoyl phosphate is synthesized by two carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the arginine-repressed from the pyrimidine-regulated CPS.</title>
            <authorList>
                <person name="Nicoloff H."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
            <dbReference type="PubMed" id="10852872"/>
            <dbReference type="DOI" id="10.1128/JB.182.12.3416-3422.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text>Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="induction">
        <text>Repressed by arginine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAB56843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888530.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RLS9"/>
    <dbReference type="SMR" id="Q9RLS9"/>
    <dbReference type="STRING" id="220668.lp_0526"/>
    <dbReference type="EnsemblBacteria" id="CCC78016">
        <property type="protein sequence ID" value="CCC78016"/>
        <property type="gene ID" value="lp_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0526"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.434"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_2_9"/>
    <dbReference type="OMA" id="HCFYRPN"/>
    <dbReference type="PhylomeDB" id="Q9RLS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-437-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000145015" description="Carbamoyl-phosphate synthase arginine-specific large chain">
        <location>
            <begin position="1"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 2" evidence="2">
        <location>
            <begin position="669"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="927"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization domain">
        <location>
            <begin position="402"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain">
        <location>
            <begin position="544"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain">
        <location>
            <begin position="928"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="695"/>
            <end position="752"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB56843." evidence="4" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB56843." evidence="4" ref="1">
        <original>Y</original>
        <variation>C</variation>
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1020" mass="108911" checksum="5015DF9BFC8F6F08" modified="2011-11-16" version="3">MPKNNAIHSIAVIGSGPIKIGQAAEFDYAGTQACLSLKAAGYHVILINSNPATIMTDTATADEVYLEPLTLTSVTKILRAAHPDALLPTLGGQTGLNLAMALDQAGVLNELKIQLLGTSLATINQAEDRAAFKTLMKRLHQPIPASTTVHHVTSALSFAEKIGYPVIVRPAFTLGGSGGGIANNAAELTQTLQRGLTMSPVTECLIEQSIAGFKEIEFEVMRDNQGTKIIVCSMENFDPVGIHTGDSIVYAPVQTLTDTEYQQLRTAALTIVEALDIRGGYNVQLAQDPNSRQYYVIEVNPRVSRSSALASKATGYPIAKIAADIAIGLNLSEIKNPVTQTTYAAFEPALDYVVAKIPRFAFDKFPTADAHLGTQMKATGEVMAIGSTLEEATLKAIASLEIDPKTQASLTPDHHVTTTEYIDQLTHPTDQRLFYLLAALQAGWPLAKLATLTQITPFFLSKLQHIAQLIRNIKQVPTSQHLLSAKKYGVSLATMAHYAQTSVATIAAMTADLPFVYKMVDTCAGEFASVTPYFYSTAFGQTNESHPLGHSILVLGSGPIRIGQGIEFDYTTVHCVKAIQQAGYHAIIVNNNPETVSTDFSTSDKLYFEPLTIERLMPIIALEQPAGVIVQFGGQTAINLAHQLTKLGVTVLGTSVSATDLTEDRQSFADCLRLLKIAQAAGTTVTELSGARQAAHAIGYPLLVRPSFVLGGRAMAIVHNDHELTPVIKSAVAAGHGAPILMDQYLAGTECEVDVLSDGTSCFIPGIMEHIEGAGVHSGDSITVYPPQHLSPAVQDKIVTIATKLAQHLHCVGMMNIQFVVTDDVYVIDVNPRASRTVPYMSKVTHLPLAQLATRLILGQSLATLGLVPGLLTPAPQQIAIKAPVFSFNKLPQSPVVLSPEMKSTGETLGIGPTFTTAWHAAMADSYHLETWQTVDGLITDIATVAQPAVQELFAANHLTVTTIANTTDWPAKTKAVGFTLNDQPDNPVAIAALNHGQPLITAIDTLKTLLAVTPTPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX0</accession>
    <name>F9UKX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional protein: acetyl-glutamate kinase acetyl-ornithine deacetylase</fullName>
            <ecNumber evidence="8">2.7.2.8</ecNumber>
            <ecNumber evidence="8">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="8"/>
    <dbReference type="EC" id="3.5.1.16" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888499.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0488"/>
    <dbReference type="EnsemblBacteria" id="CCC77985">
        <property type="protein sequence ID" value="CCC77985"/>
        <property type="gene ID" value="lp_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0488"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.402"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438639_0_0_9"/>
    <dbReference type="OMA" id="NTLATTW"/>
    <dbReference type="PhylomeDB" id="F9UKX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-406-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="612" mass="67476" checksum="812836FC21A26BCC" modified="2011-10-19" version="1">MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTLRHGNTVRYTPGKDMSIIKSAYNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLLANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTPPIFEKSVNDYINIDADMLAANLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVMKHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMANITSNIDSAGNIVLKKGSGHKKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATFLSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEKMPVIIGEPSGIEKLTLGYNGLLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQTELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQKMIPEYIVKTGTSDMNTLATQWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAIQTYLGKVTDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL27</accession>
    <name>F9UL27_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888556.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0555"/>
    <dbReference type="DNASU" id="1064219"/>
    <dbReference type="EnsemblBacteria" id="CCC78042">
        <property type="protein sequence ID" value="CCC78042"/>
        <property type="gene ID" value="lp_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0555"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.460"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538170_0_0_9"/>
    <dbReference type="OMA" id="IELPFAM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-472-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="19751" checksum="34C921C164DB7379" modified="2011-10-19" version="1">MAHIWMQRHLPARDDVVIKYMTSSQLFRIIRCLFNRTSKIEFVSVKLNLRNHTIINNVSDHDDDQGGFEMAVTKIDLKTTMTYREHAITSKSFARKLGIELPFAMYAMAAGESISAEQSTLTRLFEVVDGTLTVRLATETDQEVHAGEMLVVPAHTVHTLVAEQPCQFIQLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL46</accession>
    <name>F9UL46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system, mannose-specific EIIC component</fullName>
            <ecNumber evidence="8">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pts9C</name>
        <name evidence="8" type="ordered locus">lp_0576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888575.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0576"/>
    <dbReference type="EnsemblBacteria" id="CCC78061">
        <property type="protein sequence ID" value="CCC78061"/>
        <property type="gene ID" value="lp_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0576"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.479"/>
    <dbReference type="eggNOG" id="COG3715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069101_0_0_9"/>
    <dbReference type="OMA" id="LSWIHVS"/>
    <dbReference type="PhylomeDB" id="F9UL46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-492-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="268" mass="27244" checksum="5177E9C9A7B30CAD" modified="2011-10-19" version="1">MNLNAIQMILVVLVAFLAGMEGILDEFHFHQPVVACALIGLVTGQLVPCIILGGSLQMIALGWSNVGAAVAPDAALAAIASAIILVLGGQGRAGVSSAIAIAVPLAVAGLLLTILARTLATIIVHIMDRAAEEGSFGKLEFWHVLAICMQGLRIAIPAALILAVGAGPVKSMLNAMPAWLTDGLSIGGGMVVAVGYAMVINMMASREMWPFFALGFVLAAVSEITLIGLGAIGVAMALIYLNLSKMGGSGNGGGSNTGDPVGDIIDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB5</accession>
    <name>F9ULB5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646207.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3559"/>
    <dbReference type="DNASU" id="1061997"/>
    <dbReference type="EnsemblBacteria" id="CCC80522">
        <property type="protein sequence ID" value="CCC80522"/>
        <property type="gene ID" value="lp_3559"/>
    </dbReference>
    <dbReference type="GeneID" id="57026758"/>
    <dbReference type="KEGG" id="lpl:lp_3559"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2969"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_3_9"/>
    <dbReference type="OMA" id="QEDTEIY"/>
    <dbReference type="PhylomeDB" id="F9ULB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3010-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="114"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="30417" checksum="11C0B810D8B482ED" modified="2011-10-19" version="1">MSIVTTVEESYPTLSRQERKVALKVIQEPKEVQKMTISSLAKNVHVSNATITRFVKKMGCENFYAFKIQLAEGPVVPATTTDKKDTVADQVYSYYKKILSGTWERLSPDDLHAAVNLISKARRVYLYGLGSSGYTAQEMTQRLIRMGIAAFSMTDTHIMYISGGIMQPGDIILAISLTGATAEVNDSVALAKKKQAKVIAITSDERSRLAELSDLTILVKNSKFVNNSRFVNSQFAITYALDIIAAMLLENAKYRDRMNHTIDLITDNKFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD2</accession>
    <name>F9ULD2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
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        </source>
    </reference>
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            <begin position="54"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="81" mass="8241" checksum="9B688142A38AB7BB" modified="2011-10-19" version="1">MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEALLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="AL935263">
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    <dbReference type="EnsemblBacteria" id="CCC80543">
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    <dbReference type="eggNOG" id="COG3290">
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    <dbReference type="OMA" id="CKEIVIV"/>
    <dbReference type="PhylomeDB" id="F9ULD6"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        </location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="419" mass="48761" checksum="09DB45E3BAA7BA23" modified="2011-10-19" version="1">MLIIFLQEFFLFVITKAILKKRSIQLFDISFVAVSLGVTYAFYSLLQDRVSFLVVLLCIIYAYWYEHNISKSVIIAMEITMLSMVADHLASLVMLFFDSMRLYLLLFSIFQSLLIIMVYTVRLRTNCKPFFEDQKLNRTTAALLCIVYLYIILSEGWKNQANVIFSNLIILLVMIGLFVIIYNEYLNNVKSKYEVQKQRIQIQNDTRYMNEIEAHYNELRRFRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKSILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMSAIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILETRVLGAVFLQRLTVKRVSQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN5</accession>
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            <fullName evidence="1">Prophage P1 protein 23</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC78124.1"/>
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        </source>
    </evidence>
    <sequence length="177" mass="20300" checksum="B97CD381781A477E" modified="2011-10-19" version="1">MTETQVLVINADLPDIDHPLAIGPEPEMFKLAQHNYKSGEWPFPVRLVKPGTNVRSDEAYLASMKQDPKQGEREDIKAIRQAHKHGKHSLRQISESTAIEFKRVKDLVHKYSLPLTNDYWRAEKYNNPDEVIAYQTLARLCEKIDAPEFSIRQASMSNGVVNGYYISWVPGLKNKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW4</accession>
    <name>F9ULW4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late competence protein, ATP-dependent DNA helicase/translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comFA</name>
        <name evidence="3" type="ordered locus">lp_0735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888717.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0735"/>
    <dbReference type="EnsemblBacteria" id="CCC78203">
        <property type="protein sequence ID" value="CCC78203"/>
        <property type="gene ID" value="lp_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0735"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.619"/>
    <dbReference type="eggNOG" id="COG4098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024742_0_0_9"/>
    <dbReference type="OMA" id="VDAFPYS"/>
    <dbReference type="PhylomeDB" id="F9ULW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-638-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="109"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="50880" checksum="92523D15F99D60A2" modified="2011-10-19" version="1">MEAQVLYGRQLALSANEAAAVPAGTQILPAMQVDEHQIICQRCGSHLDRLRAQLPNQQYYCYQCLNLGRVSTLVKLYHMPEPNAFATVPVCTWQGTLTPQQADCAQSIKANFMAHKRQLLWAVTGAGKTEMLFPGIAWALAHQWRVAIASPRVDVCLELAPRLQAAFADVQIAVLHGRNPAPYQYTQLTICTTHQLLRFRQAFDVLIIDEVDAFPFAANPRLAFAVNQAAKVEGAILYLTATPSQSLLSQVHRGELAISYLPLRFHQHLLPAIKVKLQPNWARLLQQGKLPRDLIRQLQQYQQQHQRFLLFVPRIQQLAPVFAVLQHYFPHMTGETVYSADPERLTKVQQMRNQQFQYLVTTTILERGVTFPGIDVIVLGADDEVFSTAALVQIAGRVGRSSERPTGLVWFICHSHSRNIKRAQRQIRVINRKGRQLRASMPTVSQHYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX5</accession>
    <name>F9ULX5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstC</name>
        <name evidence="8" type="ordered locus">lp_0748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888728.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0748"/>
    <dbReference type="EnsemblBacteria" id="CCC78214">
        <property type="protein sequence ID" value="CCC78214"/>
        <property type="gene ID" value="lp_0748"/>
    </dbReference>
    <dbReference type="GeneID" id="57024448"/>
    <dbReference type="GeneID" id="66448716"/>
    <dbReference type="KEGG" id="lpl:lp_0748"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.629"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_9"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="PhylomeDB" id="F9ULX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-649-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="62"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="31437" checksum="F0E4FADE8CB06765" modified="2011-10-19" version="1">MNAKRIDKIATGVLYGVAAFVVIILVALLGYILIQGVPKISWHFLTSPALAFEAGGGIGIQLFNSFYLLFLALLISLPISLGAGIYLNEYAPQNTVTGLIRTTIEILSSLPSVVVGLFGYLFFVVQFKLGFSILSGAFALTVFNLPILTRSIEEALANISDNQREAGYALGLSRWETVTKIVVPAALPSILTGVVLSAGRIFGEAAALIYTAGQSAPALDFGNWNPFDISSPLSPLRPAETLAVHIWKINSEGIMPDAKAVSAGASAVLIIAVLLFNFLARWLGKRLYKHLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM27</accession>
    <name>F9UM27_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pta</name>
        <name evidence="7" type="ordered locus">lp_0807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.683"/>
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    <dbReference type="HOGENOM" id="CLU_019723_0_1_9"/>
    <dbReference type="OMA" id="TMLVKMG"/>
    <dbReference type="PhylomeDB" id="F9UM27"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="P_Ac_Bu_trans"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="6">
        <location>
            <begin position="4"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="325" mass="34422" checksum="AC842600678CE0C8" modified="2011-10-19" version="1">MDLFESLAQKITGKDQTIVFPEGTEPRIVGAAARLAADGLVKPIVLGATDKVQAVANDLNADLTGVQVLDPATYPAEDKQAMLDALVERRKGKNTPEQAAKMLEDENYFGTMLVYMGKADGMVSGAIHPTGDTVRPALQIIKTKPGSHRISGAFIMQKGEERYVFADCAINIDPDADTLAEIATQSAATAKVFDIDPKVAMLSFSTKGSAKGEMVTKVQEATAKAQAAEPELAIDGELQFDAAFVEKVGLQKAPGSKVAGHANVFVFPELQSGNIGYKIAQRFGHFEAVGPVLQGLNKPVSDLSRGCSEEDVYKVAIITAAQGLA</sequence>
</entry>
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        <name type="synonym">Lactobacillus plantarum</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101172.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0830"/>
    <dbReference type="EnsemblBacteria" id="CCC78287">
        <property type="protein sequence ID" value="CCC78287"/>
        <property type="gene ID" value="lp_0830"/>
    </dbReference>
    <dbReference type="GeneID" id="57024528"/>
    <dbReference type="KEGG" id="lpl:lp_0830"/>
    <dbReference type="eggNOG" id="COG2814">
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    <dbReference type="PhylomeDB" id="F9UM48"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="58"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="91"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="268" mass="29532" checksum="48FEEDC52F751A0C" modified="2011-10-19" version="1">MINANFRKLVLGRAVGNAGDSIYMIAMNWFILQLTNSALWIGIMNVAIVLPGVLLFLFGDSIDRHSKRRLLVAVEFSQLVIVVMLIGLVALHIKLPGIYVGLVFVAALFGSLAYPIQDTLVPLLVEPDQLVQAQADMSIAYKGTDYVFNALSGFLISLCSVLGVLIMDAATFVVTVATFRRIKLAEPRQQHTREKSLYLNQILVGFKIISTDPLLRLLTFASVVMNFFFGGLNTYVVLFGRHFGDSIYYGILESMSAVGILLGMTVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM68</accession>
    <name>F9UM68_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78307.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011101182.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888821.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0856"/>
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    <dbReference type="eggNOG" id="COG1835">
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    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="NRWLTNP"/>
    <dbReference type="PhylomeDB" id="F9UM68"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
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            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
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            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="660" mass="74394" checksum="4A97C79E90D9D714" modified="2011-10-19" version="1">MNENLRSVNMSRTMSRMNRHRMNPRRYITGFDGIRTLAVLGVIIYHLMPASLQGGYLGVPIFFVVSGYLITDILLQDILSRGHVRIWRFLGHRMRRLYPAFVTMLLGTTAYITLFQRSLLTNIRATVLTNLVYVYNWFEINHGQSYFDRFNGESPFTHLWSLSIEGQYYLFWPLVIGILMVIFKKRSRVFWFMMIAAGISAITMAMLYDPANTNRVYYGTDTRMFAILLGSGLAFIWPSRELSADIANVNRVTLDILGGASLIAIIWIFFQMSGQSDFTYRGGMLLFTVLSTVLVATVAHPASHLNRVLTNPLFKYVGQRSYGIYLYQFPVMIFYETKVKNIGDHLLLNSLIEVALILIVTELSYRFIENPMRHYDYSRLLVDFKDFLRKPKFNRVTTAIVALTTVLFVITAVGFVQQPSKAEANKKTELQKTIAANSKAADKKNAAALKRQKAAQAAAASSKKVATEKMQTKQAEAKLNSKQKQVEKEYDLKPQVVLAMANTDLTAIGDSVLLDVSSDLQDVIPGTVVQGRVGRQVTEVPGIINSLKSQGQLAHNVLLNIGTNGTITDDQAEQVVKLIGKDRQIFWVTAHVPTQSWQNQVNAQIAKTAKKHANVHVIDWHGRAQNQSGWFADDNVHPNTTGNRQLTNLIANRIAEVNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, DUF1212 family</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">lp_0998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0998"/>
    <dbReference type="EnsemblBacteria" id="CCC78422">
        <property type="protein sequence ID" value="CCC78422"/>
        <property type="gene ID" value="lp_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0998"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.845"/>
    <dbReference type="eggNOG" id="COG2966">
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    </dbReference>
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    <dbReference type="OMA" id="TLMVLFM"/>
    <dbReference type="PhylomeDB" id="F9UMI3"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="26843" checksum="C64F6878DBCF81D0" modified="2011-10-19" version="1">MTVTTDEMIIATCLKAGKIMVENGSEISRVDDTMMRIAQNAGVVAANTYVTITGVMMSIQGRNATQIAAVNQRTIDLEKVAQVNQLSREFAATTIDLPTLYQRLNQLDAASRSFPLWLQLVGAALVSGPLMIMFRQEIVNTWPTVIIGTLGYLVFYLLNRYLKIKFLSELTAALLIGFGAEWVCQIGWGTNVNDIIIGSLMPLVPGVPLTNAVRDTLAGNFVSGPARGVEAMLSAAALGFGIAVVITLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR2</accession>
    <name>F9UMR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889015.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78501">
        <property type="protein sequence ID" value="CCC78501"/>
        <property type="gene ID" value="lp_1098"/>
    </dbReference>
    <dbReference type="GeneID" id="57024747"/>
    <dbReference type="GeneID" id="66449001"/>
    <dbReference type="KEGG" id="lpl:lp_1098"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.930"/>
    <dbReference type="eggNOG" id="ENOG5033DR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158513_1_0_9"/>
    <dbReference type="OMA" id="PAKRWNE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-944-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11976" checksum="0F712F9E280613BB" modified="2011-10-19" version="1">MDNETLKDYLANNSQVITIFMEKATDFLNRKNEDRAPARRYNDAEIARQADKMLDDVIANIHDKIVPHTREQTPAAWEQFLSENDVLDDLELSMTELSFESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX1</accession>
    <name>F9UMX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1173"/>
    <dbReference type="EnsemblBacteria" id="CCC78560">
        <property type="protein sequence ID" value="CCC78560"/>
        <property type="gene ID" value="lp_1173"/>
    </dbReference>
    <dbReference type="GeneID" id="57024807"/>
    <dbReference type="KEGG" id="lpl:lp_1173"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.991"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1003-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="372" mass="41267" checksum="491F1E981CEF885B" modified="2011-10-19" version="1">MTKPIKVMTIFGTRPEAIKMAPIVLQLQQQPQFEPVTVVTAQHREMLDQVLTIFHITPDYDLNIMKPNQTLAGITSRVLTKLDAIMDTVKPDIVLVHGDTTTTFAASVSAFYHQIPVGHVEAGLRTWQKYSPYPEEMNRQLTDVLADMYFAPTELSRQNLLKENHPDTAITVTGNTAIDALKQTVSMDYQHAALDLIQPGHRMILLTMHRRENQGAPMEAVFVAIKRVVAQHPDVEVVYPVHLSPAVQTVAKRILGHTDRIHLIDPLDVLDFHNMAARSYFIMTDSGGVQEEAPSLNKPVLVLRDTTERPEGVTAGTLRLVGTDGQQVAAAMTSLLDDSAAYQRMADAKNPYGDGHAAEYILQAIMKKIGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX8</accession>
    <name>F9UMX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps1D</name>
        <name evidence="2" type="ordered locus">lp_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1180"/>
    <dbReference type="EnsemblBacteria" id="CCC78567">
        <property type="protein sequence ID" value="CCC78567"/>
        <property type="gene ID" value="lp_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1180"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.998"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065769_1_0_9"/>
    <dbReference type="OMA" id="HYRRFFS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1010-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025536">
        <property type="entry name" value="DUF4422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14393">
        <property type="entry name" value="DUF4422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4422" evidence="1">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="30435" checksum="3FFCB4449DF2754D" modified="2011-10-19" version="1">MDIKILVAAHKEAKMPTDKNLYLPIHVGAALHPELRFGYQSDATGDNISLKNGSYNELTAIYWAWKNLNADAIGLVHYRRLLSLNHKKSFSSVLSNHEAQLLLKAHAIILPKKRHYWIETNYSHYVHAHYRNPIDECRRVILDLYPDYIPFYDEVMKLRSAHMFNVFIMRKDLFDEYCQWMFSILSELEGRIDTSKYDAYESRVIGFVSELLLDVWLNKNGYDFKEVNCLFMEKQNWLIKGMNFLKRKLTGFQVSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ1</accession>
    <name>F9UMZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1193"/>
    <dbReference type="EnsemblBacteria" id="CCC78580">
        <property type="protein sequence ID" value="CCC78580"/>
        <property type="gene ID" value="lp_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1193"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1011"/>
    <dbReference type="HOGENOM" id="CLU_2666539_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1023-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8575" checksum="75C686949001916F" modified="2011-10-19" version="1">MTKQRRLAYDAIKVVSQGNRGAVSKLIAVLDVSRQTYYQGLKRQETEWESHDRVLKARTQYCLIFIVVASGPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN81</accession>
    <name>F9UN81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1302"/>
    <dbReference type="EnsemblBacteria" id="CCC78670">
        <property type="protein sequence ID" value="CCC78670"/>
        <property type="gene ID" value="lp_1302"/>
    </dbReference>
    <dbReference type="GeneID" id="57024926"/>
    <dbReference type="KEGG" id="lpl:lp_1302"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1102"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_2_5_9"/>
    <dbReference type="OMA" id="TALFMEN"/>
    <dbReference type="PhylomeDB" id="F9UN81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1128-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
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        </source>
    </reference>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78688.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="228" mass="26014" checksum="F7FB9DF150A740D6" modified="2011-10-19" version="1">MPNMSLIYGHRGVPVKFPENSLAGFAYAISHHIDGLEFDVHLTQDQIPVIMHDERIDRTTNGQGAIADLTFEQLRRFELANGEPVPSLQEFLNLVSGEPVHLNLELKTDRHYYLDIERIVLRMVRQTDLIYPVVFSSFNLKSLQRAYAIDASQKYAFLTSARLGNPDEFATHEHLEGVHLEHYQPVHHVAERVWTVDEPIVMQQLFAASVNAVITNNFELAQQVRAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA2</accession>
    <name>F9UNA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101357.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889205.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1332"/>
    <dbReference type="EnsemblBacteria" id="CCC78691">
        <property type="protein sequence ID" value="CCC78691"/>
        <property type="gene ID" value="lp_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1332"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1123"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004534_1_0_9"/>
    <dbReference type="OMA" id="YLWSFWD"/>
    <dbReference type="PhylomeDB" id="F9UNA2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1149-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="983" mass="103422" checksum="0ADF5C2604B4CD66" modified="2011-10-19" version="1">MIKAEWAYMRKHKLMIIVMAIIMFIPSIYAVTFLRSMWDPYGRLNNLPVAVVNHDQPVTYQGKHLSVGRNLTTNLKKSSALKFQQVNASQAQAGLKNGRYYMVLTIPTNFSRHATTLLNHQPQAMVLHYDTSAGHNFVASKMADSAVTSIRSSVAQTITTSYAKTMFAAIKQLDSGLKTAATNNQKLATGGQQLQTANQKIATNLDTLATSSLKLKQGSQTLTVGLNQYLNGISQLQVGNQKVVAGLTQLLVKSNQLVAGMAQLNTGVQTLNQGVDQYVAGAQRVNTGTVKVNTGAHQVASGTQQFSSGTAQLATGTQQLSSGLNAYAAGVGKVNTGANKLSQGANQLQAQTAQLTAKTTALTSGSSQLTTGIQTLGQNSQSLTIDLQKLQTQLKQPTNNQATISATVAALKKQAAGTDLSSVKTALSALTSAIKTSAALHDNVAATADSQNLTAAQKSAILATVDQSANRDAINAALASLTTAIAQSTQPAVDTTALTRALSATTQQQADLVSTVTQLTTGAQSLTTGIQSAGNAANKLRTSLTQLNTVLPNLTNGIGAVTTGATNLASGTTTLTTNSQQLTQGFKTLDANTNLLNQRSHQLATGAGQVAAGSQQLTAGTRQLSTQGNQLTQGASRVATGLQSAQTNLPSLTTGISQLVTGSQQVATGLHRLGTTGIALANGSQQLTSGNGQLATGAQQLAVGANQVTTAGNKIQTGNQALATKLGTAASKGNLNPSKLTYQQVAKPVTTTHQDRDDVPNNGTGMAPYMLSVSLFVGALALNMMFDMYTPRKHPQSALDWWSSKASIMLVFSIMESTIMLGLMMLINGLSPIHPFATWLLLTLTALLFMTIVAWLNLVFGKAGAFFSMVLLVLQLGGSAGTYPIQLSGHFFQTIHPWLPMSYSVNGLRQTLMTGNSALSAMGVLALILMLFIALTWLFFIRRYPRLAQIDFEDPVAVKATQSKLATLVRRKAQAKASDNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC2</accession>
    <name>F9UNC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1357"/>
    <dbReference type="EnsemblBacteria" id="CCC78711">
        <property type="protein sequence ID" value="CCC78711"/>
        <property type="gene ID" value="lp_1357"/>
    </dbReference>
    <dbReference type="GeneID" id="57024960"/>
    <dbReference type="KEGG" id="lpl:lp_1357"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1142"/>
    <dbReference type="eggNOG" id="ENOG5030A4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1946086_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1169-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12546" checksum="47BE5C1588F4DD18" modified="2011-10-19" version="1">MKQFWSLILMILAGCLLIFGSEYSLQGDYHRRIHRLTVSKVVYHQNATSATISGRTKHGVIVTLKSGKHVRQVISNKQSGQFYVKMPVHKRITIKVVGLKAKVLTVPTGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE7</accession>
    <name>F9UNE7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">lp_1393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1393"/>
    <dbReference type="EnsemblBacteria" id="CCC78736">
        <property type="protein sequence ID" value="CCC78736"/>
        <property type="gene ID" value="lp_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1393"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1167"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_78_2_9"/>
    <dbReference type="OMA" id="MKALGCY"/>
    <dbReference type="PhylomeDB" id="F9UNE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1198-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="664" mass="71945" checksum="E1BFD04F7043D764" modified="2011-10-19" version="1">MSYLELTNICKNYQVGKQTFNVLKDINLQFELGEFVAIVGESGGGKTTLMNIIGGLDHDFTGTVSIAGQPLDYHHERQLDQYRREVIGYISQTYNLIGHLTVLENVMLALDMTKLSHGDRLRRAHELLANVGLTAQIKKYPQQLSGGQKQRVAIARALAGDPKILIADEPTGALDADNTADVMAMLQKIAREGRLVICVTHSQRVAGAATQIAELVNGRIKSQPVTTQNVGTTQTVASLPARPLSYWVSVMMAFKHMRHTWIWNTLIVVGTAIGLFAVMLFNGLGTGIKGYINHEMNALVDPQSIMVMHQADNAKDRDEQAAAVYDPAVAGGIAARMPVFTDSQLTALRDLKHVTNVEPGISATNATIAIGQQKYAAPELTTWTSSDPTRQLKAGHVAGDNQIVLDKSSIAQKWSATRWRQLVGRAVTVSYQTFNQKGQPVTVARVLTVAGIVDSTSEVGLNAVNYTTMQSMRSAARVSTQPTFVSVRIKSRVQNQVVVNEINHLSINGKHPFAATSIAATLDSFNTYVNIATKVLAAIAGISLIVSALMIIVTMFMSVSARMREIGILRSLGERRRDIRRLFTSEALMLGIISATLATGLSYLAERGLNHGLAKLTGGYALVQIQLGNVIAIFVIAIIIAWLAAILPARRAARANPIKALAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK6</accession>
    <name>F9UNK6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">feoB</name>
        <name evidence="12" type="ordered locus">lp_1466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101417.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889309.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1466"/>
    <dbReference type="EnsemblBacteria" id="CCC78795">
        <property type="protein sequence ID" value="CCC78795"/>
        <property type="gene ID" value="lp_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1466"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1228"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_9"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="PhylomeDB" id="F9UNK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1256-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="662" mass="72972" checksum="7BC631DC57D4321F" modified="2011-10-19" version="1">MTTVALLGNPNTGKTTLFNELTDKYAYVGNWTGVTVEKKMGRIRHSEVEMVDLPGVYSLNPITKDEAVVTNYLLHNHPDLILNVTNASQLKRNLLLSIEVLEFGAPVIIALNMIDDLKRTGHYYDFDTLAEQLGCQIKATNARNKEGLHQLREDLLAGPHPAATPLKLNYPFMIEQAIRQASQQLIKKFDLTADFARWLTIQFINQNKPIRAYAKHMGLTPLTSQAAYYDAQKFDEQIFQTRLDFIEQTLASASQNLASTSHVEMTAKIDKWVTNPFLGLPVFVGIFYLMFKLSFDWVGTPLSDLLDSFVSGPLSTTVSHWLTMAGAIPVLRSLIVNGLIAGVGGVLVFIPQIFVLFACISILEDSGYMARAALVTDRLMQMIGLNGKAFIPLIIGFGCNVTGIMAARTIEQPKERLITTLISPFMSCSARLPIYSLFVAAFFPKNQALIVLSIYFLGIAVALGMAKFYQLIFNVDDSSVFIVELPQYHIPRADIIWRGTWDKGKGFIKKAGTIIFAGTVLIWLLSSFGTSGLVSDIDNSFAATLGKTLLPLFAPLGVTAWQVISALFTGILAKEVISSSMMVMFHSANQAGLIAMMGRFFTPLSAYAMLVFILLYVPCFATIGTIKSETGSTKWAVYAVCSSLVIAYTLAFVIYQVGQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ5</accession>
    <name>F9UNQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889358.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78844">
        <property type="protein sequence ID" value="CCC78844"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCC78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="103" mass="11965" checksum="0DD3574D626515EC" modified="2011-10-19" version="1">MATVLPKAVKVWMGANILQIEFDNGEFRYMRTHFIDDYVSAWSPKKGKGKRRNLWLMPSWEWLGANARIEPDGTVVLFEKDVYTAQELWHNSVTRIDLVSGVH</sequence>
</entry>
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    <accession>F9UNT2</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78871">
        <property type="protein sequence ID" value="CCC78871"/>
        <property type="gene ID" value="lp_1552"/>
    </dbReference>
    <dbReference type="GeneID" id="57025141"/>
    <dbReference type="KEGG" id="lpl:lp_1552"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1305"/>
    <dbReference type="eggNOG" id="COG5658">
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    <dbReference type="HOGENOM" id="CLU_1413588_0_0_9"/>
    <dbReference type="OMA" id="WQIRNAP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1332-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="97"/>
            <end position="115"/>
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        <location>
            <begin position="164"/>
            <end position="185"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="192" mass="21341" checksum="C1240618F0924748" modified="2011-10-19" version="1">MIPEKWQQTLGVKLFIMVNLINLVILAVIKLASGAPVWRVRNAPLAVVGGLFLIGISLILICKQNPNWRKGTYLGADINLTVLFYLLLIDFNRISTLGFALIAIIISIVALPMAYTSRNRLVGIRIPWTYLSEENWHRTNVLAGRLFGISGPLLVAMGKMSTDSFLNAFVTIIVLVVILTVGYSYRLSKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNX2</accession>
    <name>F9UNX2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress protein, Gls24 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_1597</name>
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    <organism evidence="3 4">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640347.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889425.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1597"/>
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    <dbReference type="EnsemblBacteria" id="CCC78911">
        <property type="protein sequence ID" value="CCC78911"/>
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    </dbReference>
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    <dbReference type="KEGG" id="lpl:lp_1597"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="152" mass="16437" checksum="9D7DF4CF88DE46D5" modified="2011-10-19" version="1">MADSSNITLQSKEPSLGQIQIAPEVLEIIVGIAVSQIDGVNRMQGTISSSVNELFGRKKNLGKGVKLTIVDDQISVDVFAYLDYGVSVPKVALAIQDKVKQQILFMTDLALSEVNVHITGIVTEKTESAIDPNNLFGDEDTQTDENEDGEES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP09</accession>
    <name>KHPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">RNA-binding protein KhpA</fullName>
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        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">khpA</name>
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    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="MSphere" volume="4" first="0" last="0">
            <title>CRISPR Interference for Rapid Knockdown of Essential Cell Cycle Genes in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Myrbraaten I.S."/>
                <person name="Wiull K."/>
                <person name="Salehian Z."/>
                <person name="Haavarstein L.S."/>
                <person name="Straume D."/>
                <person name="Mathiesen G."/>
                <person name="Kjos M."/>
            </authorList>
            <dbReference type="PubMed" id="30894429"/>
            <dbReference type="DOI" id="10.1128/msphere.00007-19"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Necessary for correct cell elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cell length is reduced.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889462.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1637"/>
    <dbReference type="EnsemblBacteria" id="CCC78948">
        <property type="protein sequence ID" value="CCC78948"/>
        <property type="gene ID" value="lp_1637"/>
    </dbReference>
    <dbReference type="GeneID" id="57025219"/>
    <dbReference type="GeneID" id="66449518"/>
    <dbReference type="KEGG" id="lpl:lp_1637"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1384"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_2_9"/>
    <dbReference type="OMA" id="HETDEYM"/>
    <dbReference type="PhylomeDB" id="F9UP09"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1411-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="KhpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000454537" description="RNA-binding protein KhpA">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="30894429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="85" mass="9578" checksum="1C52FB5A7E8FE8F9" modified="2011-10-19" version="1">MADIKALITTVVTPLVQYPDDIKVDFKETTRYLEYNLTVNPEDIGRVIGRQGRVASAIRTIVYSVRVSGPKRVRLTIEDGQQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP14</accession>
    <name>F9UP14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mucus-binding protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101486.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889467.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1643"/>
    <dbReference type="EnsemblBacteria" id="CCC78953">
        <property type="protein sequence ID" value="CCC78953"/>
        <property type="gene ID" value="lp_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1643"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1389"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001155_0_0_9"/>
    <dbReference type="OMA" id="DQTTRVA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1416-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041495">
        <property type="entry name" value="Mub_B2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041558">
        <property type="entry name" value="MucBP_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17966">
        <property type="entry name" value="Muc_B2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17965">
        <property type="entry name" value="MucBP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394274" evidence="3">
        <location>
            <begin position="50"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2194"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="6">
        <location>
            <begin position="632"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="868"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1394"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1491"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1601"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1698"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1808"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1905"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1986"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2165"/>
            <end position="2188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="2219" mass="236123" checksum="689619F6166E2E7F" modified="2011-10-19" version="1">MRNRLNRLGLESKSHYKLYKSGRRWVAASITVFSVGIGLTFSQVEQVKAATGTGVDTADNSASVSSDMAEPSNAVVLKSASTATATKTATQDAKAATDVTAATQDTKATTDSTGATSASSNRQSTAATKPAAEVGTASSSADSSASISSTDGASASAPSVTSKFTNTEATSASATKTATTSADTDVLNTETTSSSVANDLTDATTASQTRTETGKTASIPTAEAPTITTAVTSRALPLTGALASRSANTPVTKSAVQAVSAITSEAETKPTVSLVTTGTVSMDYGEASLADLESHISSPDETPANDVAYYIQDAAGNYLEDVNGNKVNLLYALFLDSADVNDYVDVVYTDEHGQVTKYSGDTDFSTLDQIGSYSVTINAAGKAGMSRVMQDYNAYDTSTSDLDDFVPTFSTGASDYTFTINIVPVKITATTGKNGLIILRPSQLYTGSLTMLPVVTVKNATKQNILQISNGEIGDAKPGVAGKVGQRVLTLADFTYTYQGTETNLTGADTGKYAITLNDAGRKAVQAALGSNYILDDAAVFTTTGAVQAAGLGLTIANDTVTYNGKPQGTTVAITAGTAYDHFDFTTTTDTNVGTYDDLTYALADPTQAAILAKNYTVTTTDGTLVITPADLTVTVKDDNPVYDGRAHGMTATVTSGTNYDQLAFTAVAADGSGATTYTTVGTYAMTGTTAADTSNYKISYVNGTLTIDPAKATITIPNKIYWSDGTQKNLAAVVTGTVNGETLKYRVTNGMSAVGTKTITATPDADDSVNKNYTISVIPGTLTIGDIAVKYLYEHVDANGETQVDASETGTATHATDATATDYLTYTTAAKPKTGYVLAPNTGLAYNGTLTDQGGTVTYRYLAKTETAIVTYFDQTDNKVIKTEPLQGAYGTTDAYRTADTIAAYENAGYDLVSDDYPTAGVVYDQDGSVQEYQVTLVHKFVTRTPDNPGTPGEPIDPDNPNGPTYPVGTDFEDLTEQVSQTIQYLYKDGRTAKPNNVQAVNFGRNVTVDEVNGTVVYTDWLTDDGAVTGRFEAVDSPLITGYTADPTSVAGNPGVVWQDDDTTIPVTYTVNTEYATVTYFDQTDNKVIKTEPLQGAYGTTDAYRTADTIAAYENAGYQLYRDDYPTAGVIYDHDGSVQKYQVTLVHKFVTRTPDNPGTPGEPIDPDNPNGPTYPVGTDFEDLTEQVSQTIQYLYKDGRTAKPNNVQAVNFSRNVTVDEVNGTVVYTDWLTDDGTMTGRFEAVDSPSITGYTADPTSVAGRDTVSGTDLSPDVQVYYQANPEKATVTYEDTTTGAVLTTDPVTGDYQTVSNYRTADRIAQYLNMGYELVSDDYPTSGAVFDKDGSTQAYTVKLQHKLLPLTPENPGTPGEPIDPDNPNGPTYPAGTAVQDLIKQVGQTIHYQYQDKSTAADANTQTITFKRSVTVDEVNNKLTYTDWLTGTATTGHYMPVDSPEIKGYVADSTRIAGNDEVRNADADTNIVVTYQAKPENATVTYVDVTTGKTLAIKSLTGDYQTTSSYRTAETIASYVKNGYQLVRDNYPTSGAVFDVNNFAKTYTVTLKHKLVTVTPENPGTPGQPIDPDNPDGPKYPVGTTAQDLTKQVSQTIKYRYQNGASAGTDNVQLITFNRDATIDEVEPTAVYTDWLNGTSATGRYTTVMSPVITGYTADKTQVAGRDSVANTDSDTQVVVTYAAKPEKATVTYVDVTTGKTLVTANLTGDYRTQSNYRTAETIAGYVKNGYELVRDNYPVSGMLFDVDDFAKTYTVTLKHKLVTVTPGNPGTPGQPIDPDNPDGPKYPVGTTAQDLTKQVSQTIKYRYQNGASAGTDSVQLITFNRDATIDEVEPTVVYTDWLDGTSATGRYTTVTSPVIIGYTADRARVTGNDAVTSAAQPTNIIVTYAINAEKATVTYVDVTTDKTLATVSLTGDYQTSSDYRTANTIADYSNQGYVLVRDSYPVSGAIFNDDGVVHSYLVQLAHVTTATTETKTITQTVHYQSTTGTQLHDDTVRAMTFTRTKRVDQVTGDVTYSNWSTNQADHTFERVAAFSIPGYHAVVTGTQAVMVTPASVDDVQTIRYVTDRLSTGETPKTPVKTVTVNKSDKIKTTDTPDKVATVKTPDKAQTVATTTAKQASVKRSVDLKQAQAVEQPAQTRPANVKTVKLAKTTKSVKPTAAHQSATHKQATLPQTNDDRQASVAAELLGLTAATLLVGVSAILKKRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP36</accession>
    <name>F9UP36_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpA2</name>
        <name evidence="1" type="synonym">acpP</name>
        <name evidence="5" type="ordered locus">lp_1672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1672"/>
    <dbReference type="EnsemblBacteria" id="CCC78975">
        <property type="protein sequence ID" value="CCC78975"/>
        <property type="gene ID" value="lp_1672"/>
    </dbReference>
    <dbReference type="GeneID" id="66449543"/>
    <dbReference type="KEGG" id="lpl:lp_1672"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1411"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_0_9"/>
    <dbReference type="OMA" id="VKMETTF"/>
    <dbReference type="PhylomeDB" id="F9UP36"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1438-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="82" mass="9349" checksum="9A65B1D26C88C183" modified="2011-10-19" version="1">MTKTEIFDQIKKMIVEQLDVDADKITMTTNFTEDLALDSLDVFEVIDKIEDEYDIEIETDDALATVGDLVDYVATHQETSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD2</accession>
    <name>F9UPD2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrAB2</name>
        <name evidence="11" type="ordered locus">lp_1784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1784"/>
    <dbReference type="EnsemblBacteria" id="CCC79071">
        <property type="protein sequence ID" value="CCC79071"/>
        <property type="gene ID" value="lp_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1784"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UPD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1534-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="132"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="853" mass="94309" checksum="E3930A6A52CB9B73" modified="2011-10-19" version="1">MNNQALQKVLIIGAGHNDIGREGQHDAAVTQIGAAIRRLGIAVVLVDNNAYSVAAENRFADKVYLEPLTVAALSKIIETEQPDGLIPSLGGVQTVTLIQGLIRNNVLKNNHVKLLQWDQDVVDMIVNPALMSNRLKDMGEPVIASQVVASTTEAMAVVRHVGFPVIVKSVAPRIEASRQLCEDEDELQRALAMGFKVSGTKQCIVEQSIVGYKELEFVAVRDQKDTALLVSGMENFDPVGIHSADSIVFAPTQTITDQEYQQFRSATLKIMRKLHLTGSCHVQFALDPTTQNYYVIKVTPYFDRTMALAARATEYPLAQVVGNLMVGISLAEVKLPGAYRKQTALIEPVLDHIVCRIPVWPFNVLKKVSHQLDTVTESTGSVIGIGRSTEEALLKGLRSTDESRYHVIANRPQNYSEGELIQRLIHPQAGRMLILLEALNRGYQIDELAELTKIDAFYFYKLSHILEIERALRERPFDVHALGRAKYFGFTDEDAAAAWQTDVAKVRNFALENEIQPTFKEVEPTAGEFTEQTSTYYSTYEFDNESQPSTGRRVVVIGTGANRIGTNHGNDYLVSQLLFYLKKADYEPVLINANPNSVAMTPRLAKKRYVEPKQYSDILNVLAIEKPLIVFTTYHDYRLGQKLVQDGYQVIQINNSLPREQIRTNDSPAVEVITDGTDVTIFGVSEIIAGNNLRGNVRGAVQVFPIRDKAENQAITALHAEIKQRVLAMGAPGLYTVRLAIADTALQLATIEPMSIATMALISKASGSSVTRLLLHVKLGEALTKVMYDYPDVNRLKPVYVQANTFPYNHLQIYDEVEATGEPGHATGTVIAHGDTLKAALTALNQGNEDTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPM0</accession>
    <name>F9UPM0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xerD</name>
        <name evidence="15" type="ordered locus">lp_1892</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1892"/>
    <dbReference type="EnsemblBacteria" id="CCC79159">
        <property type="protein sequence ID" value="CCC79159"/>
        <property type="gene ID" value="lp_1892"/>
    </dbReference>
    <dbReference type="GeneID" id="57025485"/>
    <dbReference type="KEGG" id="lpl:lp_1892"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1595"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_9"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="PhylomeDB" id="F9UPM0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1621-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="106"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="296" mass="33991" checksum="C3FC8A9E55B9D85A" modified="2011-10-19" version="1">MQDQLADYLHFLRVERGLVENTIKSYSQDLTTFSEYLMSQQITDYRVVDRYVLLNYLQYLDEAGKSRNTIIHSVSSLRKFFQYLAQMHAIDTDPMLKIDTPKRAQHLPQVLSPREVERLLAVPKLNTPLGLRDRTLLEVMYATGLRVSETINLTMDDLHLDLGLIQTIGKGDKERIIPIGDVAIDFITRYLKTARPKLVSAKRRNSYLFINNHGGKLSRQGVWKNLKAEVKAAGIEKNVTPHTLRHSFATHILENGADLRVVQELLGHADISTTQIYTHISKKRLAEVYNKYHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ7</accession>
    <name>F9UPQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, atypical SDR family, subgroup 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101601.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1936"/>
    <dbReference type="DNASU" id="1064099"/>
    <dbReference type="EnsemblBacteria" id="CCC79196">
        <property type="protein sequence ID" value="CCC79196"/>
        <property type="gene ID" value="lp_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1936"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1633"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="VYTEIRP"/>
    <dbReference type="PhylomeDB" id="F9UPQ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1658-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23370" checksum="CF287BC8DC2B2463" modified="2011-10-19" version="1">MTKIMIIGANGGIAKKLTQRLLAETDDELVLFLRRAERLAQYREQPRVTLIDGNVLDTDELATAMAPVDIVYSNVGGTDLAAQTKSILAAMARTQRQRLIFISALGAHHEVPGKFGAWNEQAIADFLPGFREAARLLSASELVYTEIRPAWLTDVAEIDYELTTGAEPFKGTEVSRASVADLVFKLMAHPENYQRVSLGVDEPGTAGDRPSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS4</accession>
    <name>F9UPS4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1957"/>
    <dbReference type="EnsemblBacteria" id="CCC79213">
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    <dbReference type="eggNOG" id="ENOG5030A68">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="273"/>
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    </feature>
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        <location>
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            <end position="317"/>
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            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79213.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640701.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889758.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1992"/>
    <dbReference type="EnsemblBacteria" id="CCC79244">
        <property type="protein sequence ID" value="CCC79244"/>
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    </dbReference>
    <dbReference type="GeneID" id="57025569"/>
    <dbReference type="GeneID" id="66449796"/>
    <dbReference type="KEGG" id="lpl:lp_1992"/>
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            <dbReference type="EMBL" id="CCC79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="96" mass="11677" checksum="466D3B409E2526DD" modified="2011-10-19" version="1">MLKRTKQFLRSIHYDYDKTYIRPLMVPDSVYVLKFGKDHRNNRVVVKYSHTWTGRIKINEIAVRLHKQKHPRIFKHEADMIKYLNKHLTKKTANND</sequence>
</entry>
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    <accession>F9UQ15</accession>
    <name>F9UQ15_LACPL</name>
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        <submittedName>
            <fullName evidence="2">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="primary">plsC</name>
        <name evidence="2" type="ordered locus">lp_2060</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2060"/>
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        <property type="gene ID" value="lp_2060"/>
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    <dbReference type="GeneID" id="57025610"/>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.1745"/>
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    <dbReference type="OMA" id="GASPMEF"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
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</entry>
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    <accession>F9UQ47</accession>
    <name>F9UQ47_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2 (GT2)</fullName>
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    <gene>
        <name evidence="2" type="primary">cps4I</name>
        <name evidence="2" type="ordered locus">lp_2100</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644571.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889850.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2100"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79336">
        <property type="protein sequence ID" value="CCC79336"/>
        <property type="gene ID" value="lp_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2100"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1777"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_4_9"/>
    <dbReference type="OMA" id="SADFEMI"/>
    <dbReference type="PhylomeDB" id="F9UQ47"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1797-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="322" mass="36707" checksum="29BD12AED88C48C4" modified="2011-10-19" version="1">MAISVIMSVYNERPEQVQQAVDSILKQTYLPREFVIVLDNPERSDLKDLLMDYDCRVEMIKLVCNPENLGLAASLNKAIELASSELIARMDADDISVTNRLEVELEALKTRDLDLISGNITYLDEQDEVVGEKSAIPEAEPLIQKILPYGSTIIHPTVLMRKTAVQQVGGYRLLPTAEDYDLWLRLLANGFKIGSINRRVLNYRLRGNSMTSDAWKTYLVSRYIQQLYAERKRTGADSFGRGMSALTDKINDVRAQSTFNRGQKYFTMAMASMRKRKLGQALAALVRAMVTSPDNCYYVINYLRLRTIWSVNGRRYRQQPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ49</accession>
    <name>F9UQ49_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps4G</name>
        <name evidence="3" type="ordered locus">lp_2102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101653.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889852.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2102"/>
    <dbReference type="EnsemblBacteria" id="CCC79338">
        <property type="protein sequence ID" value="CCC79338"/>
        <property type="gene ID" value="lp_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2102"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1779"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9UQ49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1799-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="38028" checksum="AFBCB50922642B1E" modified="2011-10-19" version="1">MTKIVHVLFSAKLGGAEQVVINISRGLSGSYDFTYCSQSGSIQESLQAVGIAYQSFSPKQLLKFRRAILALQPDIIHAHDFKASFLVNLLFHHVPIITHIHQAPIWQTSVNWKSLAFQYIGNKSSRVLYVSDWAKESYRFHKHLTNTAIIPNGIDSSRICQLATASTTTAFDLLFVGRLEDVKDPARFVRIAHKLLDAIPELKIGIVGDGSLSAHIAKQIAATPQIRWLGFKSNPYKYMRHAKVVLSTSKSDAFGLTMVEAALLGAIPFAPRIGGISQTAARVNGLVYASDAELLAVLTRLFSDGKFYQETKAKIAAVDFSDYEQRQFIQRIQQVYKGVMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ52</accession>
    <name>F9UQ52_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP N-acetyl glucosamine 4-epimerase, NAD dependent</fullName>
            <ecNumber evidence="2">5.3.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps4D</name>
        <name evidence="2" type="ordered locus">lp_2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.7" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640785.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889855.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2105"/>
    <dbReference type="EnsemblBacteria" id="CCC79341">
        <property type="protein sequence ID" value="CCC79341"/>
        <property type="gene ID" value="lp_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2105"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1782"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_9"/>
    <dbReference type="OMA" id="VRWMERI"/>
    <dbReference type="PhylomeDB" id="F9UQ52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1802-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050089">
        <property type="term" value="F:mannose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="313" mass="35210" checksum="B3A4668FCEFEA9ED" modified="2011-10-19" version="1">MKALVTGGAGFIGSHLVDHLVESGFEVVVVDDLSMGAISNIKHWEQITIYVADVCDDKFMQQLLADERPDYIYFLAAIASVADSIERPAETHAVNHTAVFNLLEHIRQIRLPIKQFLFTSSAAVYGNLPELPKREDSRVAPVSPYAIDKYATERFVLAYGELYDLPTVCVRFFNVYGPRQNPSSPYSGVLSILTDCLKTQRPFTLFGDGTQTRDFVYVSDVIKALWLITEHQVQHEVINIANGLETSLNGIIQMYQEIAGQQLEIKRAEQRGGEVDHSVASIGKLARLNYESEWPLRRGLTKYWEGECEHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ73</accession>
    <name>F9UQ73_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComE operon protein 3, DNA transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">comEC</name>
        <name evidence="8" type="ordered locus">lp_2129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <source>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
    <dbReference type="GeneID" id="57025805"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="152"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79468.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="18045" checksum="2983B22FC58A3A84" modified="2011-10-19" version="1">MSKKGFLLGVVLGGAAIATAVMKMDDDKKAELKAKAQQGIADFKDRAIDYAFYANDAAEDFKAEAGQQFEDTKRKVADFADQYQAAKQETGESFGSSLDQATDSLRSELAKVEDDEGDDEDIVIDGGAAYQKAGEDEKTSAPVPESAPAKDATPAKSDDESTTDESSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2335</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890043.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2335"/>
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        <property type="protein sequence ID" value="CCC79529"/>
        <property type="gene ID" value="lp_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2335"/>
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    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_097806_3_4_9"/>
    <dbReference type="OMA" id="MNLRRDV"/>
    <dbReference type="PhylomeDB" id="F9UQP0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2013-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="10651" checksum="361D30D5C24ED304" modified="2011-10-19" version="1">MALNTTFKAIADPVRRQILEDLRQNRQSAGEIAAHFKLSNATVSYHLKLLKQAGLVNVTKEKNYVYYELNASVFEEMLTWLYRFSPKQGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQR9</accession>
    <name>F9UQR9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">lp_2370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641438.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2370"/>
    <dbReference type="EnsemblBacteria" id="CCC79558">
        <property type="protein sequence ID" value="CCC79558"/>
        <property type="gene ID" value="lp_2370"/>
    </dbReference>
    <dbReference type="GeneID" id="57025902"/>
    <dbReference type="KEGG" id="lpl:lp_2370"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2003"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_3_9"/>
    <dbReference type="PhylomeDB" id="F9UQR9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2042-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="237" mass="26352" checksum="1800415059EA9183" modified="2011-10-19" version="1">MGDPVPTVKFLGLTFNIANDISVIVTCLIVFLFVFLLSRHLTMKPKGGQNVLEWLIEFTNGIVKGSIKGNEASNFGLYAFTLFLFIFIANQLGLFIHVQVGQYTYLKSPTADPIVTLTLSFMTVALAHAAGVRKKGMGGYLKEYTQPFAVFSVINVFEQFTDFLTLGLRLFGNIFAGEMLLTKVADLAKSNGWLSYVYSFPIELLWQGFSVFIGSIQAFVFVTLTSVYISQKVNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT6</accession>
    <name>F9UQT6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2395"/>
    <dbReference type="EnsemblBacteria" id="CCC79575">
        <property type="protein sequence ID" value="CCC79575"/>
        <property type="gene ID" value="lp_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2395"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2020"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="IENGRIC"/>
    <dbReference type="PhylomeDB" id="F9UQT6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2060-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="576" mass="63620" checksum="C75917CA856DF8A2" modified="2011-10-19" version="1">MLKIAKGRISYPAVIGAVLFMIVQVIATLNLPSLTSNIVNNGVATGDISYIWKIGFEMIGFSLLSVVAAFGNVFLAARSSQQLGKNLRSDIYKKVINFSNDEFDKVETSSLITRTTNDVVQIQNVAMMALRMMIMAPIMLIGASFLAYTKSHELTWIFVVSIPVLLIFIGLIMAFAIPLFRAMQTKTDRINLVFREGLTGVRVIRAFRQDKFEQDRFEDANQDYTHNAIKVNTIVALAYPVMTLIMSGTNVAIVWFGGQLISSQTMQVGNMIAFMTYAMQVLMSFMMLAMVFAFIPRAAASASRIQEVLSIEPKITDPDKAATLPATTEHSLEFDHVNYRYQSAEQLALADIDFKAHSGQTVAIIGGTGSGKTTLVNLIPRFYDIESGAVKLDGKDVRQLKLADLHQAVSFVPQTATLFTGTIRENMQFGNEHATDDEIWHALEIARSTDFVKEEGGLDAHVEQGGGNFSGGQRQRLAIARALVKQASAYVFDDSFSALDFKTDAQLRAELRQDKQIQQSVVVIVAQRIATVADADLILVLDNGKLVGKGTHAELKANNEVYQEIMKSQLREEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Prophage P2b protein 6</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="84" mass="9416" checksum="792FFD59916DB29E" modified="2011-10-19" version="1">MDIEDLRGEVIKTLGLHEALSDIVDSLSDSLEENKQNSSMVQYNLKREIRPLSSLTWAINNELIKIADATDELTIKCARAGDKK</sequence>
</entry>
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    <accession>F9UR52</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101813.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890205.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2528"/>
    <dbReference type="EnsemblBacteria" id="CCC79691">
        <property type="protein sequence ID" value="CCC79691"/>
        <property type="gene ID" value="lp_2528"/>
    </dbReference>
    <dbReference type="GeneID" id="57025955"/>
    <dbReference type="KEGG" id="lpl:lp_2528"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2127"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_4_3_9"/>
    <dbReference type="OMA" id="PPPCFIQ"/>
    <dbReference type="PhylomeDB" id="F9UR52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2184-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="16917" checksum="789408468BA856D4" modified="2011-10-19" version="1">MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGDRQAVLVGKQKINFQTTNQPHQPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGPVERTGAHGKLTSLYVRDPDNNLIEISNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR86</accession>
    <name>F9UR86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin V acylase family protein</fullName>
            <ecNumber evidence="4">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pva3</name>
        <name evidence="4" type="ordered locus">lp_2572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101831.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2572"/>
    <dbReference type="EnsemblBacteria" id="CCC79725">
        <property type="protein sequence ID" value="CCC79725"/>
        <property type="gene ID" value="lp_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2572"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2161"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_0_9"/>
    <dbReference type="OMA" id="CAELYLP"/>
    <dbReference type="PhylomeDB" id="F9UR86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2217-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="317" mass="35767" checksum="9BF0CE4EECBEC197" modified="2011-10-19" version="1">MCTSLTYLDTDNHRYFARTMDFPTTTPWRPIFLPRRYPWPTGLATTRMTQYAILGGGRLPDHFKACLMADSINEAGLVCAELYLPHAVEYATQSQVNQINLTPQAFINWALGEHQSVAAVIADLPSVNLVGASWGDDTGEVYPFHWYLSDAHTSAVIEPTGGPLTVQPNPAGVLTNTPVLSDHQRRLNRYLAVSGNQITTATRQAAQHVIQTKQPLPSGPIPTDRFIHMALRRLGTPQLAPQQVPTTLFRWLQEVSLPYHADRRHLISHNYTHYRCLITLATRTYRFIPRTTGHEQRLTLTPEMATTWRTPYLFPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR97</accession>
    <name>F9UR97_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell surface adherence protein,collagen-binding domain, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101838.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890250.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2588"/>
    <dbReference type="EnsemblBacteria" id="CCC79736">
        <property type="protein sequence ID" value="CCC79736"/>
        <property type="gene ID" value="lp_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2588"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2172"/>
    <dbReference type="eggNOG" id="COG3827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028174_0_0_9"/>
    <dbReference type="OMA" id="RINWTIR"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2227-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041171">
        <property type="entry name" value="SDR_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17961">
        <property type="entry name" value="Big_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388963" evidence="8">
        <location>
            <begin position="29"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Big_8" evidence="9">
        <location>
            <begin position="64"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="570" mass="60675" checksum="7B72E57C589474ED" modified="2011-10-19" version="1">MRKKWRWLLLALTGIFFLMFGPPLVSQARNVIEATGNDVNSAVIKDSKGKIMAHDAQLPEDQEYTVNYNWRIPDNLKIKAGDTMAFQVPENVRIPHDEAFPMKGTTAGTIGTFFIAAGAHTGLVTFNQAYQTRPRNRKGFVQLDAFGTVPSHPGNLAPILLEKSAEWADEANPRRINWTIRVLPNNNQLVDPTFVDTLSPNQTYVNGSAVLRDETGNIIPVNTSVNGNQLTFNATGSFTSELALTYQTKTNEPTGDATFENNVTYTDKNGNKGSATATISRPVTEPDVPENPGISEPTDPDEDEEPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGVTEPEKPGTTEPEKPGITEPEKPGTVSPEQPSGPKPTNPGTVTPEKPTAVTPAVPNESSPSTPEPSVSGNLSAPANPATNSTNTTATTVPATNPLPASAATAFAGSAPMNKSLPQTNEHSASWSVAIGLALLIGLLGSAFVLTRRTKHRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC4</accession>
    <name>F9URC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2622"/>
    <dbReference type="EnsemblBacteria" id="CCC79763">
        <property type="protein sequence ID" value="CCC79763"/>
        <property type="gene ID" value="lp_2622"/>
    </dbReference>
    <dbReference type="GeneID" id="57026023"/>
    <dbReference type="GeneID" id="66450305"/>
    <dbReference type="KEGG" id="lpl:lp_2622"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2202"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_4_0_9"/>
    <dbReference type="OMA" id="WERGDRS"/>
    <dbReference type="PhylomeDB" id="F9URC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2254-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="138" mass="16006" checksum="EB43C2E3B4EED15B" modified="2011-10-19" version="1">MFPERLRALRRGQKMTLAQLAAALNQMPTADKTTRQNTAAQIGNWERDLRTPSYLEVRKLAEFFNVTTDYLSGKSDQEEYDLGRIFLSGKPLTFNQEQLSSEDRYELFQLMDGYLHGRQHRVSTDATGQEELDLHFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG4</accession>
    <name>F9URG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2676"/>
    <dbReference type="EnsemblBacteria" id="CCC79803">
        <property type="protein sequence ID" value="CCC79803"/>
        <property type="gene ID" value="lp_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2676"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2242"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_1_9"/>
    <dbReference type="OMA" id="YFEASPN"/>
    <dbReference type="PhylomeDB" id="F9URG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2294-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="14478" checksum="448D7ABC9544C655" modified="2011-10-19" version="1">MRLFTIPAEQTAFSTKEVVAITGMTKDALRYYEQQRLIGPVPRNHNNYRQYSRQNLERLQFVATFRQLGLDLKLLSGDGHIPNRAQRIQELSSYRATVKKQIAQLQATDQFLAHKIAYFEASPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK4</accession>
    <name>F9URK4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="5 7">N5-CAIR synthase</shortName>
            <ecNumber evidence="5 7">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">purK1</name>
        <name evidence="5 7" type="synonym">purK</name>
        <name evidence="9" type="ordered locus">lp_2728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="5 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101896.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890357.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2728"/>
    <dbReference type="EnsemblBacteria" id="CCC79843">
        <property type="protein sequence ID" value="CCC79843"/>
        <property type="gene ID" value="lp_2728"/>
    </dbReference>
    <dbReference type="GeneID" id="57026103"/>
    <dbReference type="KEGG" id="lpl:lp_2728"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2283"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_9"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="PhylomeDB" id="F9URK4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2334-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="115"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="376" mass="40503" checksum="FC3B974763F63621" modified="2011-10-19" version="1">MNANFKEALLPPATIGIVGGGQLGQMMTLSAKAMGYRVGVLDPTPKAPAAQVADFQIVAAYDDQAALLDLARRSDVLTYEFENVDENALIAAQAYAKLPQGTALLHITGDRLNEKQFLHDHGIPVTSFAPVTDLQSLNYALNRVGTPAILKTAAGGYDGHGQTDLDTAVVTKAASALLTQPCILEARQKFRTEVSMMVTRSAAGVVTTFPLVENQHQHHILHTTIAPANVQPSVHSAARKIAVSIAESLELRGVLGIEFFVLPDDTLLVNELAPRPHNSGHYTIEACNISQFEAHIRSICGLPIPAITQTSPAVMRNLLGDDLTVARQQLVEHPEWHFHDYGKAAIKPQRKMGHVTVLNHDIDAALASLANLKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM6</accession>
    <name>F9URM6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642563.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890379.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2754"/>
    <dbReference type="EnsemblBacteria" id="CCC79865">
        <property type="protein sequence ID" value="CCC79865"/>
        <property type="gene ID" value="lp_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2754"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2305"/>
    <dbReference type="eggNOG" id="ENOG50300NC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094536_0_0_9"/>
    <dbReference type="OMA" id="KKNWQNG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2356-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="24076" checksum="10BD3F085F0333F5" modified="2011-10-19" version="1">MTSAWNWIGIIAWIIVLALVVWVFHHIRVRRIKMIVERKHTFEWGNLIITTVELIVSLGLLVGMGYVTFNHQVDLSDAKDVKVTYQVEPLVLRVGTNGSYYVAVDRGTTQKPVHIYNYWVNGAKYTVSSNKATVVTNLSQVKVADAGIPWSQKQLVKEDRQHEKAYAVKLTATYQPSFWNGLGVHVGHQAMTRWLIRVPAQSFINTTDVQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR4</accession>
    <name>F9URR4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroC1</name>
        <name evidence="3" type="ordered locus">lp_2798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890417.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2798"/>
    <dbReference type="EnsemblBacteria" id="CCC79903">
        <property type="protein sequence ID" value="CCC79903"/>
        <property type="gene ID" value="lp_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2798"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2343"/>
    <dbReference type="eggNOG" id="COG0710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064444_0_0_9"/>
    <dbReference type="OMA" id="TKQMRAN"/>
    <dbReference type="PhylomeDB" id="F9URR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2394-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="26580" checksum="AC07DA1DC6EC0553" modified="2011-10-19" version="1">MKEVTVGELTLATGMPKIGVVLAGATREDLLRKAGQILTSVAQIVVWRLDPYQELDNRAELVNTAAQLQQVLGTIPLIAMFGLANDPAEVTEYYQTYQTLVNNRSVAGVDIDLAMVNQPDFMTLTKQMRANEIRLIASQTVTTATTDDLLATYHELAATGADVVRVTVAGHDAQTVLALMAATEQARQQLVVPIVATATGKFGRYNSVCSQLTGSAVAFGHVGRVGDQSQLAVSQVKQALQMLAPLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR6</accession>
    <name>F9URR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator. MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890419.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2800"/>
    <dbReference type="EnsemblBacteria" id="CCC79905">
        <property type="protein sequence ID" value="CCC79905"/>
        <property type="gene ID" value="lp_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2800"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2345"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076858_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9URR6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2396-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388111" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="29330" checksum="AFC44BB089C8DEC8" modified="2011-10-19" version="1">MLVVIALKPLSASPIFTPASSLYACGLTDFFVTLIDNLFATADSAKNCQRWFWYYQPLLVGMRVHVTFQSLICGSQSYTFYTFSGMILSEYSQSKFTKQSLFKEVLIMATVDALDMFLTDYANISRYLNTRLNSLLATQHLTFDAFLIMHEIGQSPQPLLLMEIAHQHHVSRSAISRQIGVLLKHRYIEQQANATDRRQKGLSLTATGRHLDQQLMATMHKTVHQWTTQLGPQRVKTLLGIFTDFNEQIINNEVPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX3</accession>
    <name>F9URX3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase, zinc-binding</fullName>
            <ecNumber evidence="5">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adh2</name>
        <name evidence="5" type="ordered locus">lp_2873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890476.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URX3"/>
    <dbReference type="STRING" id="220668.lp_2873"/>
    <dbReference type="EnsemblBacteria" id="CCC79962">
        <property type="protein sequence ID" value="CCC79962"/>
        <property type="gene ID" value="lp_2873"/>
    </dbReference>
    <dbReference type="GeneID" id="57026225"/>
    <dbReference type="KEGG" id="lpl:lp_2873"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2405"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_9"/>
    <dbReference type="OMA" id="TGWFGAV"/>
    <dbReference type="PhylomeDB" id="F9URX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2459-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="178"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="346" mass="36692" checksum="98900F9F28933713" modified="2011-10-19" version="1">MKAATFIEPGKVEVKEYDKPTIQKPTDAIIRVLRACVCGSDLWWFRGISQRQAGSTVGHEAIGIVESVGSAVKDVQAGDFVIAPFTHGCGHCAACLAGFDGDCLNQEAGGNGGYQGEYLRFTNANWALVKIPGQPEDYSDDMLNNFLALADVMATGFHAATSAEVKKDDTVVVMGDGAVGLSGVLSAKLLGAKRIIAMSRHEDRQKLAKAFGATDIIAERGDEAVAKVMALTETGADAVLECVGTEQSVDTAVKVGRPGAVVGRVGVPQKAEMNTNNLFWKNIGLRGGIAAVTTDDKQVLLDAVLTGKIQPGQVFTKRFMLDDIQAAYEAMDQRNAIKSLVIVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9US22</accession>
    <name>F9US22_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dus3</name>
        <name evidence="13" type="ordered locus">lp_2937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2937"/>
    <dbReference type="EnsemblBacteria" id="CCC80011">
        <property type="protein sequence ID" value="CCC80011"/>
        <property type="gene ID" value="lp_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2937"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2453"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_9"/>
    <dbReference type="OMA" id="LIYPYVD"/>
    <dbReference type="PhylomeDB" id="F9US22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2507-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="334" mass="37860" checksum="3FB0F57BBF8478F7" modified="2011-10-19" version="1">MTQSPYWQRIAAKAQAAQRPFFSLAPMEAVTGSVFRRVVMRAAAPDVFYTEFTNALSITHPKAKFTTRGRLYVDEAESPRPIVQLWGNSGEDFTKAAHEVKNQGYQAIDLNMGCPDMAVIKNHSGSDLIRHFDRAKEVIEGARQAELPVSVKTRLGFDDVHEYETWIPFLLQQQVPVLTVHVRTKMEMSKVPAHYELIDNLVQMRDTLAPATLLQINGDILDYQAGLKLAKAHPGVDGIMIGRGIFQNPYAFEPIPQPHSTRDMLELLRYQVDLYDQFIGLGLQGHFAPLQRFFKIYVRGMRHAAELRNELMQTKTTDDVRAIIDRLEAKLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9US35</accession>
    <name>F9US35_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641630.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0004"/>
    <dbReference type="EnsemblBacteria" id="CCC77582">
        <property type="protein sequence ID" value="CCC77582"/>
        <property type="gene ID" value="lp_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="57026866"/>
    <dbReference type="KEGG" id="lpl:lp_0004"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3"/>
    <dbReference type="eggNOG" id="COG2501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127162_2_0_9"/>
    <dbReference type="OMA" id="GMAKWYL"/>
    <dbReference type="PhylomeDB" id="F9US35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="77" mass="8661" checksum="71161987CB11938E" modified="2011-10-19" version="1">MKQPIDIKTPYMTLGQLLKETAIIGSGGQAKWFLKETTVLVNGEPDDRRGRKLYPGDTIEVEDNGSFFIRSNQETTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9US65</accession>
    <name>F9US65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888126.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0041"/>
    <dbReference type="EnsemblBacteria" id="CCC77612">
        <property type="protein sequence ID" value="CCC77612"/>
        <property type="gene ID" value="lp_0041"/>
    </dbReference>
    <dbReference type="GeneID" id="57026898"/>
    <dbReference type="GeneID" id="66448191"/>
    <dbReference type="KEGG" id="lpl:lp_0041"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.34"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073253_0_0_9"/>
    <dbReference type="OMA" id="VLECNHD"/>
    <dbReference type="PhylomeDB" id="F9US65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-34-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="30106" checksum="C666FCBE26F58297" modified="2011-10-19" version="1">MVLKLATDDMKVSILASGSTGNVTYIETPEHKVLVDAGLSGKKIANLMASIDRDINEVDSLFISHEHTDHCHSAGILARKYGMDVYANQGTWDAMAHKIGNVPAELCHVFDPNTTLGLGDLDVESFSVSHDAAEPQFYELHHAGKSFVIITDTGYVSEHVEGVIKDADGYLFECNHDLEMLRMGRYPWPLKQRIIGDEGHLSNEDGANALMDVIGRHTKRIYLGHRSQDNNLKSLAHLTVASMMTERDFGVEHDFQLYDTEPEQATKLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9US80</accession>
    <name>F9US80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888141.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US80"/>
    <dbReference type="STRING" id="220668.lp_0060"/>
    <dbReference type="EnsemblBacteria" id="CCC77627">
        <property type="protein sequence ID" value="CCC77627"/>
        <property type="gene ID" value="lp_0060"/>
    </dbReference>
    <dbReference type="GeneID" id="66448207"/>
    <dbReference type="KEGG" id="lpl:lp_0060"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.49"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_9"/>
    <dbReference type="OMA" id="MDYADLE"/>
    <dbReference type="PhylomeDB" id="F9US80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-49-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="286" mass="32092" checksum="7ACC89BF2AC1931D" modified="2011-10-19" version="1">MKDFKDKVMFITGAAHGFGQVIAEGAADRGMKLTIVDIDEPALKKTYQHILDKGAEVLMVTADVTKEASVDDAVEQAMEKFGRIDLLINNAGIALPGRIWELPTRDWEWIMHINLMSQVYAMKRVIPIMIQQKTHADILNVASIAGLVDTPGMPSYHASKFASVGMTEATAYDLQRANIDIDMHVMCPGFVQTDLYHTENHRPAQYSDPTDPYYQSEAYLKGQQFAKYVITNGKPIDTIADTVFKALEDNRFYILTHPEYNPLIEDRVKRIVTDGAPDVHIMDGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9US82</accession>
    <name>F9US82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641675.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US82"/>
    <dbReference type="STRING" id="220668.lp_0062"/>
    <dbReference type="EnsemblBacteria" id="CCC77629">
        <property type="protein sequence ID" value="CCC77629"/>
        <property type="gene ID" value="lp_0062"/>
    </dbReference>
    <dbReference type="GeneID" id="57026914"/>
    <dbReference type="KEGG" id="lpl:lp_0062"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.51"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_5_9"/>
    <dbReference type="OMA" id="VNAQPWR"/>
    <dbReference type="PhylomeDB" id="F9US82"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-51-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="24270" checksum="C3BA4F3CD52376D6" modified="2011-10-19" version="1">MSEAVKNLVNNDLADVMFNRHSVRQFDPNVKIGRDELQKMIAEAATAPSACNLQSWHFVVVDTPEAKAKFKQAVMKFNYPQVDSASAIVFIAGDTQSHYVYRDVWNKVYEDGNITKERLDQILGTFLPLYENATPDFLKFDATIDCSVVGMQLLLVARAHGYDANAFSGIDFEKMIPTLGLDPKRYVPVMGIAIGKAAQEPLHTTRYDAKTQTDFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE3</accession>
    <name>F9USE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80073">
        <property type="protein sequence ID" value="CCC80073"/>
        <property type="gene ID" value="lp_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3016"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2519"/>
    <dbReference type="eggNOG" id="ENOG5030B3N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364785_0_0_9"/>
    <dbReference type="OMA" id="MSALIIM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2567-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="22143" checksum="212BBE99D2062D89" modified="2011-10-19" version="1">MAQLAKRTAIPVRLQIVGTMSALIIMYAWGRSLIGQPLQLGNQQFTWLGLVYLTGAFLFLLVAPWLTNRLALTPFDFIAMTDHLTMGWLGYLILILVVPIWFQPANSGLTLGVLSSVVGGICMDVPQNVTWGIRVPWTYNSPVIWKKVNWLTGLLLLIASYGMVGIGWVWPTLFPIYQVSAIVGIIVIALGYAHHLAHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ3</accession>
    <name>F9USJ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890637.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80123">
        <property type="protein sequence ID" value="CCC80123"/>
        <property type="gene ID" value="lp_3077"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3077"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2570"/>
    <dbReference type="eggNOG" id="ENOG50309K8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025968_0_0_9"/>
    <dbReference type="OMA" id="NTHFIIV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2616-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041498">
        <property type="entry name" value="Big_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17936">
        <property type="entry name" value="Big_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394412" evidence="2">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Big_6" evidence="3">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="29340" checksum="2B582B9FDBB9F0F7" modified="2011-10-19" version="1">MKKLMIAVTGLAMVATLGAAVPVTGITANAATKKTTATKNVAPSLKVNAIYNNTTQITGTATKGAKITVKSTANAKKNLGTATASKTTGKYTVKLAKTLKAQSNVYVYATNPTTKAYFYRVIRVQTAKTTASSTKKTTNKTTTTKKVATKSTAATSSSKKTTKSFKVNAPAGTWKSNTTNKYSQILTFSAKNGFNQTLYKNGKQVKKLVSYASYSMTAKTPTFWKVSYKSGSTTKTLYLRYTATNKFTVVNAKNQIVKVKVGNAPAAVWTFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ7</accession>
    <name>F9USJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3081"/>
    <dbReference type="EnsemblBacteria" id="CCC80127">
        <property type="protein sequence ID" value="CCC80127"/>
        <property type="gene ID" value="lp_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3081"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2574"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_9"/>
    <dbReference type="PhylomeDB" id="F9USJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2620-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13845" checksum="6C44B0BBC8248613" modified="2011-10-19" version="1">METKTYHIGVEATMEIIGGKWKSIILCHLRTQTMRTSELERAIPQISQKMLVQQLRELEAANIVTRKVYQQVPPRVEYGLSDYGRSLSVVLHELCVWGEDNIDRRRAAGEEIALLHRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP3</accession>
    <name>F9USP3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, beta-glucosides-specific EIIBCA component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts24BCA</name>
        <name evidence="16" type="ordered locus">lp_3133</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642375.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890687.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3133"/>
    <dbReference type="EnsemblBacteria" id="CCC80173">
        <property type="protein sequence ID" value="CCC80173"/>
        <property type="gene ID" value="lp_3133"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3133"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2621"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_3_9"/>
    <dbReference type="OMA" id="LEHCSTR"/>
    <dbReference type="PhylomeDB" id="F9USP3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2666-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
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    </dbReference>
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        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="102"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="483"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="615" mass="65242" checksum="D86075E5D9E16FC2" modified="2011-10-19" version="1">MDFNDSAQAIILNVGGEKNINSLIHCSTRLRFTLNDFAKADLEKLKTVDGVLGAVIAGGQCQVIIGNDVVEMFDAVQALLGNSTQQNTARGPKQSWGKVVLDFIIGVFQPLVPAIAGGGILKAVLMLLAMFGWISDKSQTYQILNLVGGAPLYLLPILVAITTAQKLKVNPLVAVSTVGVLILPDLVAMLTKGTTLFGLHVTNVTYSSQVFPAILCVLFYALMERFFTKYSPKPIRIFFVPMMSMLITAPITLLFLGPLGYVVGEGFVSVILFLNTHLGWVATALLAGVLPFMVATGMHKPMIPYVVSTFSTVGKESLYLPASLAHNISESGTCFAITLRTKDTKLRAVALSAGISALFGITEPALYGVTLQHKRALISVITGGVIGGAYVGIAGLSGFTIVGPGLASLPMFVDKSNPANLIHALIGFGISFVVSFVIGLIIWKNDEEISSASDTGEATTTVVAEDLMAPVAGKILSLADVPDDVFSQGLIGQGIAVEPSEGSLIAPTDGTIEMVYETKHALGMRTDNGAELLFHIGLDTVQLNGKYFESHVQVGQHVQAGELLETFDVAKIKAAGYNPITMMVVTNQDSYTVAVDESNETLDNQSVMNIAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV7</accession>
    <name>F9USV7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5 diketo-D-gluconic acid-like reductase,NADP dependent, promiscuous</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646328.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888202.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USV7"/>
    <dbReference type="STRING" id="220668.lp_0136"/>
    <dbReference type="EnsemblBacteria" id="CCC77688">
        <property type="protein sequence ID" value="CCC77688"/>
        <property type="gene ID" value="lp_0136"/>
    </dbReference>
    <dbReference type="GeneID" id="57026975"/>
    <dbReference type="KEGG" id="lpl:lp_0136"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.112"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="OMA" id="HKSKGIH"/>
    <dbReference type="PhylomeDB" id="F9USV7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-110-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="282" mass="30820" checksum="06889AF05A74357C" modified="2011-10-19" version="1">MTVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVGQAIRDSGIPREQIFVTTKLPAETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVGRVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNILNQATIPPMVNQIQYYLGFTEPKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPKAVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX0</accession>
    <name>F9USX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0156"/>
    <dbReference type="EnsemblBacteria" id="CCC77701">
        <property type="protein sequence ID" value="CCC77701"/>
        <property type="gene ID" value="lp_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0156"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.126"/>
    <dbReference type="eggNOG" id="ENOG50309KU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064731_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-123-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="270" mass="30729" checksum="2876D7CE6E28AEF6" modified="2011-10-19" version="1">MWRHRFLIKGSEQELAWLNAQAQRRYLLMAIHGNWYQFKKVPTIYRVFSEYVPQAIAADMSNSNSAFQVLAQVQVQQPDVQIVYTGSDQPALQQTTMAPTDPKIRLQVALQLRDQAMNTINLSLYAGVVVWGLFLILILHQGDTDLIGVWMLMLLVGLLAVLGLYRTAHRLQNQISQLRRDTEQYDGAWMPTMHVFVSALTADLDTEKPALKSLGRWTLVGHSKKGQYWYDLQTLANAAEIKQTLRPFVTTDTNVNVLSWLGLAPLGWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY1</accession>
    <name>F9USY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone phosphotransferase,ADP-binding subunit</fullName>
            <ecNumber evidence="2">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dak2</name>
        <name evidence="2" type="ordered locus">lp_0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.29" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641764.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0169"/>
    <dbReference type="EnsemblBacteria" id="CCC77712">
        <property type="protein sequence ID" value="CCC77712"/>
        <property type="gene ID" value="lp_0169"/>
    </dbReference>
    <dbReference type="GeneID" id="57026999"/>
    <dbReference type="KEGG" id="lpl:lp_0169"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.137"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066424_2_0_9"/>
    <dbReference type="OMA" id="FFRRWMT"/>
    <dbReference type="PhylomeDB" id="F9USY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-134-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="193" mass="20004" checksum="E1A44EE7C2679FA8" modified="2011-10-19" version="1">MLTVENTTVWLNKFADQIEQHQSYLSELDTPIGDGDHGGNMARGLAAVKAALATQPADITKLFQATAMALISKVGGASGPLYGTAFLEMAKQSKIDSDLGGLLAAALAGIEKRGGATTGDKTLIDVWAPVVQAVQAGELTQDVIDDAVASTEPMVAKKGRASYLGERSVGHLDPGAVSSGYLFTTLLDTEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT08</accession>
    <name>F9UT08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_0201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0201"/>
    <dbReference type="EnsemblBacteria" id="CCC77739">
        <property type="protein sequence ID" value="CCC77739"/>
        <property type="gene ID" value="lp_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0201"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.165"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="RSGWCAD"/>
    <dbReference type="PhylomeDB" id="F9UT08"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-161-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388139" evidence="9">
        <location>
            <begin position="39"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="10">
        <location>
            <begin position="87"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="553" mass="61126" checksum="77E444C4BE4CDA6A" modified="2011-10-19" version="1">MQWKLFATVATLTATTGVLLVGCGQSSSSSSNAGNTTAKMAKTQVLNWSENGQDLTTLDPSLATDVISGTMISNSQEGLYRLGKNSKVTPGIATKTTVSKDKKTYTFTLRKNAKWSNGDQVTAQDFVYGWRRTVNPKTASQYAYLYSGIKNADKIVSGKAKTSTLGIKADGKYKLTVKLEKPMQYFKLLMGFVVFFPQNQHAVEKYGKDYGTSSSKMVYNGPFKMTGWKGTNSTWTLKRNPNYWDKKHVYLTKIKDQVVKSTTTAFNLFQSNKLDMATLSGQQVKNEKNNNKLVIRKSSRLNYLEFNQKKVKLLANKKIRQAMSLTLNRKQLVNDVLGDGSVTPKGFVTTGLATDPTTGKDFATENTVKSAVTQDTTKAKKLWKQGLKETGKKSVTLTLTHDDTDQMKALAEYVQGQLEKELPGLKVQSVTVPYKTRISREIAGNFQLVISAWQADFADPVSDLGIMTSTNDYNFGKWTNKTFDSAINTANSTTSTTKRWQALATAEKTMATDQGVAPLSQNVIAQMVNPKLKGLVYNTAGINYNFKSAYMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT61</accession>
    <name>F9UT61_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, trehalose-specific IIBC component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts4ABC</name>
        <name evidence="16" type="ordered locus">lp_0264</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643705.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888306.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0264"/>
    <dbReference type="EnsemblBacteria" id="CCC77792">
        <property type="protein sequence ID" value="CCC77792"/>
        <property type="gene ID" value="lp_0264"/>
    </dbReference>
    <dbReference type="GeneID" id="57027082"/>
    <dbReference type="KEGG" id="lpl:lp_0264"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.219"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_10_0_9"/>
    <dbReference type="OMA" id="NIQELAW"/>
    <dbReference type="PhylomeDB" id="F9UT61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-214-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="305"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC77792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="665" mass="69490" checksum="6685726D1D8DB74B" modified="2011-10-19" version="1">MAKAQTVTILSPVNGDVIALNKVKDPVFSAGMMGLGFGVQPSSGEVVAPVSGQVTMVAETKHAIGFTTPDDHLEVLVHLGIDTVDLKGAPFTVKVAAGDDVQAGDVIATMDLAAIQAANRQTTVILAVTNTSDKLESLDVVTGAKAAGDVTATGRLNANTFNAKRQNRLPKAGKYDQLAADIVANVGGVENVSSLIHCITRLRFYLKDESKANDDVVRDLKGVIDVAKAGGQYQVVIGPAVTDVYDAIIKQIGPGFSNDSETAKAVAETAAAAQRPTTPWGKVKWGISNLIGVITGSMIPVIGLLAASGILKGILALLTTFNLVSPTAPTYVIINAMGDSVFYFLPIFVGFTAGKKLGADPVIMGIIGGVLTYPAIVTMASGKATSTLLGMGINANFFGLPVHVASYTYSIFPMIAGAWLASKLEPWLKRVIPTVLRMIFVPLFEVVIVSGAILLFLGPIITVLSTGLANIIVWVYNLSPAISGLIIGGFYQVLVIFGLHWAVIPIVANDIATTGHSYLNAIVSATMVAQGGAVFAIALKSKLANIQELAWPATISAFCGVTEPAMYGINLKYGRAFVTASIGAAVGGFLTGLMNVNMWGFTGSLIGFTSFVNPKGLDFSFYGFLIASAATIVVSFALTWMFGFKDEDANAVKVAPKKRHLGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT75</accession>
    <name>F9UT75_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile acid 7-alpha-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.106</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">baiE</name>
        <name evidence="2" type="ordered locus">lp_3159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.106" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642396.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3159"/>
    <dbReference type="DNASU" id="1063989"/>
    <dbReference type="EnsemblBacteria" id="CCC80193">
        <property type="protein sequence ID" value="CCC80193"/>
        <property type="gene ID" value="lp_3159"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3159"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2641"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_3_0_9"/>
    <dbReference type="OMA" id="HCADRRL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2683-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033988">
        <property type="term" value="F:bile-acid 7alpha-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16748" checksum="51C58846F37723AE" modified="2011-10-19" version="1">MMDIQEVSDRLALKQVVDLFSNYSDTKENEKQVQLFLPNGKVNIINDGKVTFTLNGRQEILNAFSSSMDDYSAVFHMSGQQTVSFTDATHADGIAYNYVTLVKTNEQGQTVTTNEGVRYQDKYGKVDGQWYIAERNSNFIWHTEDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT91</accession>
    <name>F9UT91_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642413.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890723.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3178"/>
    <dbReference type="EnsemblBacteria" id="CCC80209">
        <property type="protein sequence ID" value="CCC80209"/>
        <property type="gene ID" value="lp_3178"/>
    </dbReference>
    <dbReference type="GeneID" id="57026471"/>
    <dbReference type="KEGG" id="lpl:lp_3178"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2657"/>
    <dbReference type="eggNOG" id="ENOG50331GC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072584_0_0_9"/>
    <dbReference type="OMA" id="SIWNDNT"/>
    <dbReference type="PhylomeDB" id="F9UT91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2697-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4352"/>
    </dbReference>
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        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20194" checksum="C2517843927957CC" modified="2011-10-19" version="1">MQKTKAWYQKWWAWVLILLGIFFVISLVNSPQDGKNSQAATTKKTSASKSTAKETPANTIYKVGQTATIDHVQVTVNNVKTATTLNDVQPKTGNQYYTVTVTLKNSGRDKVSYNPFDFKIKAAGNQTSLDEINIDENNQLDSGDLTAGGSVSGTMTGQAKADGSVELIYNPSYFSDRHLTFKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT96</accession>
    <name>F9UT96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_3185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642420.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890728.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3185"/>
    <dbReference type="EnsemblBacteria" id="CCC80214">
        <property type="protein sequence ID" value="CCC80214"/>
        <property type="gene ID" value="lp_3185"/>
    </dbReference>
    <dbReference type="GeneID" id="57026476"/>
    <dbReference type="KEGG" id="lpl:lp_3185"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2662"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9UT96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2702-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="28954" checksum="4CA62291A5D4DE7E" modified="2011-10-19" version="1">MVLEAFLVKKNEPNWLVVLRTVMPLGLSYIPIGLACGVLLHAAGFNHLLTALISVMVFSGGAQFLIASMLTINAPMTTIILMMFFLELRYALLGSSLSRYLKGQSLPFIFTFAFSMNDENYAVNYLKFATDKHWKPSQALMVEHYSLLFWTVSNIIGSLIGSALTINLQVVDFALTALFIYMAIMQTKSRLIILVAVLSGVLTIGFLVLMKSTLGLVVSTLLASLTGYFIERYLLAHKPESHLLYKVHDPTGQTAMEESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA6</accession>
    <name>F9UTA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639829.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890738.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3197"/>
    <dbReference type="EnsemblBacteria" id="CCC80224">
        <property type="protein sequence ID" value="CCC80224"/>
        <property type="gene ID" value="lp_3197"/>
    </dbReference>
    <dbReference type="GeneID" id="49395223"/>
    <dbReference type="GeneID" id="57026486"/>
    <dbReference type="GeneID" id="66450746"/>
    <dbReference type="KEGG" id="lpl:lp_3197"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2672"/>
    <dbReference type="eggNOG" id="COG4481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180138_0_2_9"/>
    <dbReference type="OMA" id="RIKCLGC"/>
    <dbReference type="PhylomeDB" id="F9UTA6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2712-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037263">
        <property type="entry name" value="DUF951_bac"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="63" mass="7207" checksum="E4D6598B1D0FA81A" modified="2011-10-19" version="1">MYDLGDIVEMKKAHPCGVNRWEITRMGADIKIKCTGCGHVVMMPRREFNKKLKKVLESKADQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG8</accession>
    <name>F9UTG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102103.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890800.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3278"/>
    <dbReference type="EnsemblBacteria" id="CCC80286">
        <property type="protein sequence ID" value="CCC80286"/>
        <property type="gene ID" value="lp_3278"/>
    </dbReference>
    <dbReference type="GeneID" id="66450814"/>
    <dbReference type="KEGG" id="lpl:lp_3278"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2735"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_9"/>
    <dbReference type="OMA" id="VGTWQVP"/>
    <dbReference type="PhylomeDB" id="F9UTG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2774-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="474" mass="51188" checksum="1A5A59C222C3A0F0" modified="2011-10-19" version="1">MDLSHTRLLRKKDINAMLATYHSPLKKELKTFDLTMLGIGAIIGTGIFVLTGTGALTAGPGLMISFVLAAIACLFASLCYAEFAAMVPESGSAYTYAYTTLGEIVAFIIGWDLMLEYLFAVSTVSAGWSGYFQSFLAGFGLKLPAALSAAAGSVPGVTSYFNLPAFTIIILITTLLSLGVKETKRVNNVMVVIKLAVVLLFIFTAVRFIKPANWSPLLPFGFKGVFGAASSVFFAFIGFDAISSSVEETLEPSKTLPRSMLLSLGICTILYVAVSAIMTGVVPFETFAKYIDHPISAVLIYSGQNWMAGIIDLGAILGMTTVMLVCLYGQTRISFSMSRDGLLPHVFSDISAKTGAPLKSTVLFGSIAAIMGGFIPLADLAELVNIGTLTAFTLVSFSILRLRKTQPDLRRPFKTPWVPFVPIMSIICCVFLLINLKPVTWIRFVVWLAIGMVVYFGYSVKHSQLKTDTATDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ2</accession>
    <name>F9UTQ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888336.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0297"/>
    <dbReference type="EnsemblBacteria" id="CCC77822">
        <property type="protein sequence ID" value="CCC77822"/>
        <property type="gene ID" value="lp_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0297"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.250"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024308_0_0_9"/>
    <dbReference type="OMA" id="ERNANNW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-244-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394426" evidence="1">
        <location>
            <begin position="28"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="685" mass="75716" checksum="9F84C689438A3F19" modified="2011-10-19" version="1">MKEVRFWGLLLGLFVCLGAVIPLVSKADVLDTAPAGLNLEGLFEPGKFDRNSATMQTVLKNGHSQHVIELTNDDNQVGAMWSTPVNRFNMRVDNQVSMWVNFGDKAVSEGLAVVLQNDPHKMSAISRYGKKSIIGENLGVYGTDTYTRRTAPATIAKTAIQKSWALELDTKVNDGGFWGLYPRGNSFDEKPKKMHMAASYPASPDTYTQRGGLTSSYRFEQNHGSIADKLPLADGNWHHLVLKWVASKQIMSYTLDQGPTRMTTIDTTVFGKDIRNVTWGLTSTATTANARTLVVFDRLPQPIEIESDLNVTNLTQERTVHEGDWVHGGDELEYEYVLSYLNGDNEWQQVKASLPLPEQVHFSHAKIRYADGTDEEINLPADDNESSVARLQHDLQRTLSMKNPHAYITLIGEAAKVDRDTFVDDDMSYFEGHEMKTATATPHFTITTNKTVNLTIEPLTQVKKGEPVIIKGQIKLNDGLDFDNDGMRIEYRVNGEAGEDYQLSMDDPVGYVEFEVDAEELQIGENQITLRAHSKDNAYSEPVTVTVTVIGGELQLKKVSTESVFAPIKLTGTAQVSRPEGLEVVVNDDTGSKAAWRLEATATPLVTNQGRTLAGNLYYQDGAKLTMLGKDAVEIARQKTAPGIDYDVTAHWSSQQGLVLKTTPAAVPGSYQGTITWHLSTVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT7</accession>
    <name>F9UTT7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0335</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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    <sequence length="81" mass="9372" checksum="3E97FDA4E310256F" modified="2011-10-19" version="1">MDENVLFNPGDAISESHDYNEALRSADIYNARHGRKRGLMIARPLEQDHGYSVFYADDLLTADTPRPEARQYHVEKRIPKE</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77860.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC77860">
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        <property type="gene ID" value="lp_0338"/>
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    <accession>F9UTU6</accession>
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            <fullName evidence="2">Transcription regulator, PadR family</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:18369"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="1.1.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.21" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888402.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0371"/>
    <dbReference type="EnsemblBacteria" id="CCC77888">
        <property type="protein sequence ID" value="CCC77888"/>
        <property type="gene ID" value="lp_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="57027178"/>
    <dbReference type="KEGG" id="lpl:lp_0371"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.315"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_5_2_9"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="PhylomeDB" id="F9UTW8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-310-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004369">
        <property type="term" value="F:glycerol-3-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="11">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="12">
        <location>
            <begin position="464"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="609" mass="66613" checksum="3B4546133186C803" modified="2011-10-19" version="1">MAFSATTRQQNIERLQNETLDLLVIGGGITGAGVAIQSTAMNMKTGLIDMQDFAEGTSSRSTKLVHGGIRYLKTFDVGVVADTVKERAVVQGIAPHIPKPDPMLLPIYDETGATFDLFSVKVAMDLYDKLAEVKDPKFTNYTLSREEVLQREPQLNPKHLVGGGVYLDFRNNDARLVIENIKKAHENGGIMASHVKATGLLHDDDGRINGITAEDLLTGASFEIHARIVINTTGPWSDTIRKMDHTEKYQSQMRPTKGVHLVVDAEKLPVPQPTYFDSGDQDGRMIFVVPRENKTYFGTTDTDYHGDLKHPTVTQEDVDYLLEIVNRRFPTAKITLDDIEASWAGLRPLIAANGSSDYNGGNSGKISDKSFKEVIKVVDQFESQEASREDVESVLNDLETSLAEDKLSPSAVSRGSSLTSSPDGLLTLAGGKITDYRKMAAGAMALIAKILADKYDAHFNEINSKNLPVSGGDIDPHNVDATIAFYAKQGTDNGLTNDEALRIANMYGSNAARVFSLIGKVEPTHGLSLAETISLRYALDEEMTLTPVDYLLRRTNHLLFMRDTLDGLKDGVIATMADYLGWDAATVKAQTELLNQTIAESDLTALKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU88</accession>
    <name>F9UU88_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3409"/>
    <dbReference type="EnsemblBacteria" id="CCC80390">
        <property type="protein sequence ID" value="CCC80390"/>
        <property type="gene ID" value="lp_3409"/>
    </dbReference>
    <dbReference type="GeneID" id="57026636"/>
    <dbReference type="KEGG" id="lpl:lp_3409"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2839"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426359_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UU88"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2877-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="21314" checksum="614380E640DDFF0D" modified="2011-10-19" version="1">MVVKDASVVETAMMIQFWQRGYYQTTVDDLLTVSQLSRTQFYRQYHSKRVALRRSLERYQITLDEQLDQLIQRERARQTPLPALIAACLRLPFQSERWPAGCLMVNLMAEIGSQDASLMAQLQTIYADLQTRLVGLLSPQAKTLPTTVAEAAASLMQVRSGIQLLAKQDPSGAQLKQQAQTSVNLIMGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUA0</accession>
    <name>F9UUA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular protein,gamma-D-glutamate-meso-diaminopimelate muropeptidase</fullName>
            <ecNumber evidence="7">3.4.19.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.11" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3421"/>
    <dbReference type="EnsemblBacteria" id="CCC80402">
        <property type="protein sequence ID" value="CCC80402"/>
        <property type="gene ID" value="lp_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3421"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2851"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_1_0_9"/>
    <dbReference type="OMA" id="ILYWGSA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2889-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="6">
        <location>
            <begin position="251"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="370" mass="36812" checksum="9301AD77BF50AC19" modified="2011-10-19" version="1">MKYIRDILFGVIIIKVKVNIKQVMLGTAALAGMLVTSQAVANADSMTIKAGDTVWAYAQKYHVSVDKIAEANGLSNPNLIIAGKTINIPGVKTGEKVTTKTTTASASSAKSTSAATSTSSQATSAAATSSSTTSASSTSQAVSSSSVAAQSSSTSTASASSVTSSASTSSVASQASSSAVTSSATSQSSASQSSASQASQSSTPVASSTSTTATSTQSAATSTSSQASSTASNTTSSSTTTATATAYSASASTSTSTTSSTASYSSVIAAAKTFIGTPYEQMDCSAFTQAAFAKVGRSIGRTTYAQATIGTHVSFSQAQAGDLIFWGSDSAPYHVGIYLGGGQYIASPTYGETVSIKSTAYYTPSFAIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC8</accession>
    <name>F9UUC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscD family,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890944.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063518"/>
    <dbReference type="EnsemblBacteria" id="CCC80430">
        <property type="protein sequence ID" value="CCC80430"/>
        <property type="gene ID" value="lp_3458"/>
    </dbReference>
    <dbReference type="GeneID" id="57026676"/>
    <dbReference type="KEGG" id="lpl:lp_3458"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2878"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_9"/>
    <dbReference type="OMA" id="CMVTLSA"/>
    <dbReference type="PhylomeDB" id="F9UUC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2918-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22131" checksum="DF1BF329DB707ADA" modified="2011-10-19" version="1">MPAKKTFQDDQVIEKIMHLFWQQGYYHTSMDEIVITSGVKKQSLYNAIGDKHTLYLRALQRYHQQTLMRCTQAMQRLEQDGAAPLAILSMLFSHDLTTSEQPAGDLMANAVAEFGTTDTDVQQAVSWFYDDYLTLMAAVILKGQANEQIINNQSSMTLAQALLEARIGLQTRLRQGSQPDIQAQQQAWMAFLARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD2</accession>
    <name>GLPF6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol uptake facilitator protein-like 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glpF6</name>
        <name evidence="6" type="ordered locus">lp_3463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102173.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890948.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UUD2"/>
    <dbReference type="SMR" id="F9UUD2"/>
    <dbReference type="STRING" id="220668.lp_3463"/>
    <dbReference type="EnsemblBacteria" id="CCC80434">
        <property type="protein sequence ID" value="CCC80434"/>
        <property type="gene ID" value="lp_3463"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3463"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2882"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_2_9"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="PhylomeDB" id="F9UUD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2922-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441647" description="Glycerol uptake facilitator protein-like 6">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="5">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="216" mass="22133" checksum="8FBAE12AF4867A66" modified="2011-10-19" version="1">MRKYLAEFLGTFMLVFLGTATVVIAKGDVLAIGLAFGLAITVSAYAFGGISGGHFNPAVTTAMLINRRIDAADAIGYIIAQIIGAIVASAAVKSFVSALGLSATLLGQTDFPKIGSGMAFFVEALVTFLFLMVILNVTSNDHGNADFAGLTIGVTLAFLIIVALNLTGGSLNPARSIGPAIFAGGSALSHLWVYILAPEVGAILAAFCARVMGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD3</accession>
    <name>F9UUD3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone biosynthesis protein, ABC1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubiB</name>
        <name evidence="3" type="ordered locus">lp_3464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643556.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890949.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3464"/>
    <dbReference type="EnsemblBacteria" id="CCC80435">
        <property type="protein sequence ID" value="CCC80435"/>
        <property type="gene ID" value="lp_3464"/>
    </dbReference>
    <dbReference type="GeneID" id="57026681"/>
    <dbReference type="KEGG" id="lpl:lp_3464"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2883"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_9"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="PhylomeDB" id="F9UUD3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2923-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="578" mass="65563" checksum="10F9309CF82B8265" modified="2011-10-19" version="1">MTNNNEERPQWQVNQNRHTRFRTIVSVLRRYNVLSNLARQKNPDQVRAAFEELGPTFIKIGQILSSRTDIVKPEFANEFKKLQNNVRADDFSVVKQTIEQQTGKPINEMFAQFDERPFASASMGQTHHATLLNGQKVVVKVQHPGIDAEVALDISLFERALPLLRYIPESSVVDLREMVGEIKRSLFNELDTSIEVKNGLRFYRLNNADDIIRVPRVYAKYSTQKVLVNQYMPGTTIQHFMAQMLAADEDGNHQYDDERRYLAHVLVQNFLKQVFEDGFFHADPHPGNILLRELQPDDIGYHDTVPKHGGKIGKRQLPPYRLVYLDFGMMGEISPALMAGIANVVVAVTTEDTHQVGKAILAISNRTGVVDEEAFFSELAPFLSQYYNSGLGDIDFQGLLFEMVKVCRSNNIQMNPAVTMLGKAFGTIEGIVETLDPTLSMMDVARPFARKYIRENFNWRNELEDGMLASLQSLRDAPKIPSRLLSALDTFENGQTRVNLVFAHRKMFIDRIDSMVNKIVLSVILAALIVGSSLLVQSHPDNSWITNIGIFGYVSAVVVIIGLLIGTLHSWYTHWRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>P59407</accession>
    <accession>F9ULC3</accession>
    <name>NANA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">N-acetylneuraminate lyase</fullName>
            <shortName evidence="1 3">NAL</shortName>
            <shortName evidence="1 3">Neu5Ac lyase</shortName>
            <ecNumber evidence="1 2">4.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylneuraminate pyruvate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylneuraminic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sialate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1 3">Sialic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sialic acid lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nanA</name>
        <name type="ordered locus">lp_3568</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Appl. Environ. Microbiol." volume="77" first="2471" last="2478">
            <title>Molecular characterization of a novel N-acetylneuraminate lyase from Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Sanchez-Carron G."/>
                <person name="Garcia-Garcia M.I."/>
                <person name="Lopez-Rodriguez A.B."/>
                <person name="Jimenez-Garcia S."/>
                <person name="Sola-Carvajal A."/>
                <person name="Garcia-Carmona F."/>
                <person name="Sanchez-Ferrer A."/>
            </authorList>
            <dbReference type="PubMed" id="21317263"/>
            <dbReference type="DOI" id="10.1128/AEM.02927-10"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBUNIT</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>BIOTECHNOLOGY</scope>
        <scope>3D-STRUCTURE MODELING</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>aceneuramate = N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">1.8 mM for N-acetylneuraminate</KM>
            <KM evidence="2">160 mM for N-acetyl-D-mannosamine</KM>
            <KM evidence="2">19.9 mM for pyruvate</KM>
            <text evidence="2">kcat is 10.08 sec(-1) for the cleavage of Neu5Ac and 4.8 sec(-1) for the synthetic reaction.</text>
        </kinetics>
        <phDependence>
            <text evidence="2">Optimum pH is 7-7.3 in both synthetic and cleavage directions. Is active over a broad pH range, from pH 5.0 to 9.0, in both directions. Maintains 5 to 10% activity in the synthetic direction above pH 11.0. The enzyme is also stable at basic pHs, where it maintains around 80% residual synthetic activity after 15 days of incubation.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="2">Optimum temperature is 60 degrees Celsius for synthetic activity and up to 70 degrees Celsius for the cleavage reaction. Is very thermostable, maintaining 80% of cleavage activity after 48 hours at 60 degrees Celsius. However, at higher temperatures (70 degrees Celsius), activity decreases to less than 10% in 8 hours. Temperature stability is further improved by the presence of stabilizing additives.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">The good synthetic activity of this enzyme at basic pHs, together with its thermostability and pH stability at such pHs, underlines the potential biotechnological application of this new NAL for the chemo-enzymatic synthesis of sialic acid and its derivatives. Thus, these characteristics make this enzyme a promising biocatalyst.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="1 2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59407"/>
    <dbReference type="SMR" id="P59407"/>
    <dbReference type="STRING" id="220668.lp_3568"/>
    <dbReference type="EnsemblBacteria" id="CCC80530">
        <property type="protein sequence ID" value="CCC80530"/>
        <property type="gene ID" value="lp_3568"/>
    </dbReference>
    <dbReference type="GeneID" id="57026766"/>
    <dbReference type="KEGG" id="lpl:lp_3568"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2977"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_6_0_9"/>
    <dbReference type="OMA" id="VVPPVCT"/>
    <dbReference type="PhylomeDB" id="P59407"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3018-MON"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00954">
        <property type="entry name" value="NAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01237">
        <property type="entry name" value="N_acetylneuram_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005264">
        <property type="entry name" value="NanA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000103215" description="N-acetylneuraminate lyase">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in proton transfer during cleavage" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="21317263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21317263"/>
        </source>
    </evidence>
    <sequence length="292" mass="32708" checksum="4184967AE9C91747" modified="2003-03-25" version="1">MSKKLLYAAQMTAFDKDGNINLDGIRALVRYNIDVNKVDGLYVCGSTGEAFMLNTDEKKQVMETVYDEANGAIDLVAQVGSLNLKEAKELAKFATDLGYPKLSAVTPFYYNFTFEQIKDYYNEILKDVDNKLLIYSIPALTGVALTTDQFAELFENPKIIGIKYTNADFYLLERVRNAFPDKLILSGFDEMLLPALALNVDGCIGSTYNLNAPRVREEMDAFEAGDIDKARQLQNISNDMITDLIANDIYPTLKLVMKHMGVDAGYVKKPMSHPTPEMEAGATAIYEKYFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE2</accession>
    <name>Q6LWE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traB</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003590767.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133749.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723585"/>
    <dbReference type="EnsemblBacteria" id="CAG17866">
        <property type="protein sequence ID" value="CAG17866"/>
        <property type="gene ID" value="CAG17866"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17866"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3113"/>
    <dbReference type="eggNOG" id="ENOG50309WK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177845_0_0_9"/>
    <dbReference type="OMA" id="KSEVYHA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3166-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031607">
        <property type="entry name" value="T4SS_CagC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16943">
        <property type="entry name" value="T4SS_CagC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004276284" evidence="2">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="11717" checksum="FDA68F7CA0D39497" modified="2004-07-05" version="1">MKFSKVKALATTGATAIYLGLMNTQVVLAADGGEVQSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPDADDPREKSEVYHAVGRVAGLVALAAAVIWLLPWVYSLFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UB3</accession>
    <accession>F9URA2</accession>
    <name>Y2594_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Putative sugar uptake protein lp_2594</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2594</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101841.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890255.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UB3"/>
    <dbReference type="SMR" id="Q88UB3"/>
    <dbReference type="STRING" id="220668.lp_2594"/>
    <dbReference type="EnsemblBacteria" id="CCC79741">
        <property type="protein sequence ID" value="CCC79741"/>
        <property type="gene ID" value="lp_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2594"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2177"/>
    <dbReference type="eggNOG" id="COG4975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076024_0_0_9"/>
    <dbReference type="OMA" id="FCISMIS"/>
    <dbReference type="PhylomeDB" id="Q88UB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2232-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213654" description="Putative sugar uptake protein lp_2594">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="282" mass="30283" checksum="E4A1D5120D51B3CA" modified="2003-06-01" version="1">MIFLIAIIPALCWGINPLLVGKINGHSENEMFGMGIGDGLIALIFWLFSQPTVTISGVTFGLAMISGAAWAIGQLGQYISYRLLGVSKTMPISTALQLVGTSLIGVLMFGEWGSSNQKILGLLAIMLIVAGSALSAGTSDGRKKGFSCYLPLLMTTIGYWIYSCIPKLVKVDALQLFLPQMLGILIVAVGWAIYHQPTVYRDKQSWQNTLPGILYGIAAFMYILSARSIGVTNAYIIGQLSVVISTLSGLFFLHERTGQQSIVSVATGLLFIFMGCVTTALI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UT2</accession>
    <accession>F9UQS5</accession>
    <name>RF1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">lp_2378</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641433.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UT2"/>
    <dbReference type="SMR" id="Q88UT2"/>
    <dbReference type="STRING" id="220668.lp_2378"/>
    <dbReference type="PRIDE" id="Q88UT2"/>
    <dbReference type="EnsemblBacteria" id="CCC79564">
        <property type="protein sequence ID" value="CCC79564"/>
        <property type="gene ID" value="lp_2378"/>
    </dbReference>
    <dbReference type="GeneID" id="57025908"/>
    <dbReference type="GeneID" id="66450121"/>
    <dbReference type="KEGG" id="lpl:lp_2378"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2010"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_9"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="PhylomeDB" id="Q88UT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2049-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177686" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <sequence length="360" mass="41069" checksum="BAEFDC7AD5D0F013" modified="2003-06-20" version="1">MDKFFDKLQAVADRYEELGELLSDPEVISDSQRFMKLSKEMGNIRETVEKYNHYKEVTSQIEENDELLHEKLDDEMNAMVKDDLKNLNAEKDQLEHEITLLMLPKDPNDDKNIIMEIHGAAGGDEASLFAADLFNMYSKYAERQGWQVEVADRNETEVGGFKEIVLIISGDKVYSKLKYESGAHRVQRVPVTESAGRVHTSTATVGVMPEAQDVDIDIDQKDIRTDVFRSSGAGGQHINKTSSAVRMTHLPTGIVVSMQDQRSQQQNRAKAMEILRARVYDYYQSREQNEYDAERKSAVGTGDRSERIRTYNFPQNRVTDHRIGLTLNKLDRVMNGELDEVIDALVLADQAEKMERLTNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UV8</accession>
    <accession>F9UQP8</accession>
    <name>DDL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="2">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ddl</name>
        <name type="ordered locus">lp_2345</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UV8"/>
    <dbReference type="SMR" id="Q88UV8"/>
    <dbReference type="STRING" id="220668.lp_2345"/>
    <dbReference type="EnsemblBacteria" id="CCC79537">
        <property type="protein sequence ID" value="CCC79537"/>
        <property type="gene ID" value="lp_2345"/>
    </dbReference>
    <dbReference type="GeneID" id="57025881"/>
    <dbReference type="KEGG" id="lpl:lp_2345"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1982"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_1_9"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="PhylomeDB" id="Q88UV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2021-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177833" description="D-alanine--D-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="142"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="172"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <sequence length="370" mass="41347" checksum="28F5EB160958095B" modified="2003-06-01" version="1">METQKKIHVGMLFGGNSSEHDVSKRSAHNIYDAMDKNKYEIDLFLITKNGIVLSDAATRRVFDGEPEDQVVAEEMPKLDMSDPLAPIKNLTLAKDIDIFYPVVHGNLGEDGTLQGLFKLLKKPYVGSGVLASAASFDKDITKQILTHHHIQNTKYVVVTPENRDQMTYAYLQAHVGDHLFIKPANQGSSIGIHKAENEQEYLDGLADAFKYDYKILVEESIDNPREVECSILGNENPKASKLGAIDVPKTDTFYDYNNKFVDASGVTFELPVELPADLTKRIQQMSLDAFKALGLKGMARVDFLVSEDGEPYLGEINTLPGFTNISLYPKLWEVSGISYTALIDQLIQLGFDEFKRQSDIHYDFVALDAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V41</accession>
    <accession>F9UQG5</accession>
    <name>ACKA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetate kinase</fullName>
            <ecNumber evidence="1">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ackA</name>
        <name type="ordered locus">lp_2242</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V41"/>
    <dbReference type="SMR" id="Q88V41"/>
    <dbReference type="STRING" id="220668.lp_2242"/>
    <dbReference type="EnsemblBacteria" id="CCC79454">
        <property type="protein sequence ID" value="CCC79454"/>
        <property type="gene ID" value="lp_2242"/>
    </dbReference>
    <dbReference type="GeneID" id="57025790"/>
    <dbReference type="KEGG" id="lpl:lp_2242"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1896"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_9"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="PhylomeDB" id="Q88V41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1939-MON"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000107571" description="Acetate kinase">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <sequence length="397" mass="43475" checksum="4707AD945EFD834E" modified="2003-06-01" version="1">MGKTIAINAGSSTLKFKLFEMPQERVIAQGAVERIGFKTSPVNIRYGVDHHYQEKAVVADHLAAVNIVLDELIKLRIIDSYDEITGVGHRVVAGGEQFHDSVLITDQVLKQITDLAEYAPLHNPANAVGIRAFKRVLPHVPAVAVFDTAFHASMPAVNYLYSLPYDYYQRYGARKFGAHGTSHRYVAVRAAKLLGRPLETLKLITLHLGAGSSITAIDHGQSLDTSMGFTPLAGITMATRSGDVDPSLVAYLMKKLNISDPDEMLTILNTQSGLLGLAGSADMQELEARYDEDSQAQLAIDIFVNRIVKYVGAYLAELQGADALVITAGIGERDARMRQRIADRLTYFGVAIDPTKNQVSGVERDLSTTDAKIRTLLIPTDEELMIARDVERVAQNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VK7</accession>
    <accession>F9UPZ7</accession>
    <name>IF2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">lp_2040</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889800.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VK7"/>
    <dbReference type="SMR" id="Q88VK7"/>
    <dbReference type="STRING" id="220668.lp_2040"/>
    <dbReference type="EnsemblBacteria" id="CCC79286">
        <property type="protein sequence ID" value="CCC79286"/>
        <property type="gene ID" value="lp_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2040"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1725"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_0_9"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="PhylomeDB" id="Q88VK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1747-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137213" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="359"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="393"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="468"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="504"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="414"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="468"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="858" mass="93662" checksum="27EC1625CC380891" modified="2003-06-01" version="1">MGKKRIYELAKELNVPSKQLIAQAQQLGFSVKNHMSTLGDSEARQLQGTTTVTHPKSQPAPAKTSRATQAVAKNVTRTANQQQSNSRHQQSGDYLNNNRNNNQNNSQSRNSNGNRSNNGGNRTNSNNGNRSANASRSNSARNNGGSNTNRSNNNNNNNRSNNNNRSNTSNNRTNSTGNRTNNGGQNRNNNRTTTNNNNNNSNRSNGSNNSSRNGSGRFGGSLNSNNNGGGRYRGGNNNNRRRNNRNNKSRNNKNQRIRQVNNKPAPVRKDKPLPETLVYTVGMNAQDLGKLLHREPAEIIKKLFMLGVAVNQNQSLDKDTIEILATDYGINAQEKVQVDVTDLDKFFDDEVNNTDNLAPRAPVVTVMGHVDHGKTTLLDQLRHTHVTEGEAGGITQAIGAYQVKHDGKVITFLDTPGHAAFTEMRARGADITDITVLVVAADDGVMPQTIEAINHAKAAKVPIIVAVNKIDKPGANPNHVMEQLTEYGLIPEDWGGDTIFVQISAKFGKNLDELLDMILLQSEVLELTANPKQNAAGSVLEASLDRGKGSTATLLVQQGTMHVGDPIVVGNTYGKVRTMTNDHGKRIKEAVPSTPIEITGLNDVPDAGDRFVVFDDEKTARDAGEQRAKQALMEERKQTAHVTLDNLFDSMKQGELKEVDVIIKADVQGSVEALAGSLRKIDVEGVRVNIIHTAVGAINESDVALAEASNAIIIGFNVRPTPQAKAQADTDDVDIRLHQVIYNAIDEIESAMKGMLEPTYKEEITGQAEIREIYKVSKIGTIGGGMVTDGVIHRDSGVRVIRDGVVIYDGKLASLRRFKDDVKEVKQGFELGLRIEDYNDIKVNDVIEAYVMKEVPVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VN0</accession>
    <accession>F9UPX4</accession>
    <name>LEPA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4 1</fullName>
            <shortName evidence="1">EF-4 1</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA1</name>
        <name type="ordered locus">lp_2015</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640703.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889777.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VN0"/>
    <dbReference type="SMR" id="Q88VN0"/>
    <dbReference type="STRING" id="220668.lp_2015"/>
    <dbReference type="EnsemblBacteria" id="CCC79263">
        <property type="protein sequence ID" value="CCC79263"/>
        <property type="gene ID" value="lp_2015"/>
    </dbReference>
    <dbReference type="GeneID" id="57025571"/>
    <dbReference type="GeneID" id="66449798"/>
    <dbReference type="KEGG" id="lpl:lp_2015"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1702"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_9"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="PhylomeDB" id="Q88VN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1725-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176286" description="Elongation factor 4 1">
        <location>
            <begin position="1"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="611" mass="68345" checksum="34A20EC7AF339D33" modified="2003-06-01" version="1">MDKATMQDRQQHIRNFSIVAHIDHGKSTLADRILELTDTISKREMQDQVLDSMDLERERGITIKLNAVELHYQAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAVLVVDAAQGVEAQTLANVYLAIDDDLEIVPVINKIDLPSAEPEKVRKEIEDDIGIDAEDAVLASAKAGIGIEDLLEQIVHKIPAPQGDLDAPLKALVFDSVYDDYRGVVLSVRIHEGIVRPGDRIRLMNSGSEYEVTEVGVNSPKPLARDYLMAGDVGYITASIKDIQDTRVGDTVTNAKNPAEKPLAGYREMNPMVYAGIYPTDNAKFTDLREALEKLKLNDAALEFEAESSQALGFGFRCGFLGLLHMDVIQERLEREFNLELITTAPSVTYHVRMTDGTEKKVENPAEMPEASAIKEIREPYVKAQIMVPNDYVGAVMELAQRKRGEFDTMEYLDSNRVNVVYHIPLSEIIFDFFDKLKSNTRGYASLDYDLDGYRASDLVKIDILLNGDQVDALSFIAHRDFAPARGREIAAKLKTIIPRQNFEIPVQATIGSKVIARTNIKAYRKDVTAHLYGGDRTRRMKLLEKQKAGKKRMKAVGKVEIPQEAFMAVLKTDEDEKPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VY1</accession>
    <accession>F9UPM4</accession>
    <name>PFKA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="1">ATP-PFK</shortName>
            <shortName evidence="1">Phosphofructokinase</shortName>
            <ecNumber evidence="1">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfkA</name>
        <name type="synonym">pfk</name>
        <name type="ordered locus">lp_1898</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640604.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VY1"/>
    <dbReference type="SMR" id="Q88VY1"/>
    <dbReference type="STRING" id="220668.lp_1898"/>
    <dbReference type="EnsemblBacteria" id="CCC79163">
        <property type="protein sequence ID" value="CCC79163"/>
        <property type="gene ID" value="lp_1898"/>
    </dbReference>
    <dbReference type="GeneID" id="57025489"/>
    <dbReference type="GeneID" id="66449721"/>
    <dbReference type="KEGG" id="lpl:lp_1898"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1599"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_9"/>
    <dbReference type="OMA" id="KFAVICV"/>
    <dbReference type="PhylomeDB" id="Q88VY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1625-MON"/>
    <dbReference type="SABIO-RK" id="Q88VY1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000111959" description="ATP-dependent 6-phosphofructokinase">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <sequence length="320" mass="34266" checksum="8DD32DD469261668" modified="2003-06-16" version="1">MKRIGILTSGGDAPGMNAAVRAVAGKAMAEGLEAYGINYGFAGLVAGDIHKIEAADLDGVIQRGGTLLYSARYPEFAHEEGQLKGIEQLKRFGIDALVVIGGDGSYHGALRLTEHGYNTIGLPGTIDNDIPYTDFTIGFDTAVNTNVQALDRIYDTAHSHDRTFVVEVMGRGAGDVALWSGVSIGATAIVVPEVDWDMEEIANKIKHNRANGHRSNLIVLAEGVMGAQEFVEKLSEYGDFDARGNTIAHMQRGGNPTAKDRVMASKMGAYAVELLLAGKGGLAVGIQNNQLVNHNILDLFESKHDVEVSLDKLNEEISFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W33</accession>
    <accession>F9UPH2</accession>
    <name>MSRB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="1">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrB</name>
        <name type="synonym">msrA3</name>
        <name type="ordered locus">lp_1836</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644417.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889625.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W33"/>
    <dbReference type="SMR" id="Q88W33"/>
    <dbReference type="STRING" id="220668.lp_1836"/>
    <dbReference type="EnsemblBacteria" id="CCC79111">
        <property type="protein sequence ID" value="CCC79111"/>
        <property type="gene ID" value="lp_1836"/>
    </dbReference>
    <dbReference type="GeneID" id="57025441"/>
    <dbReference type="KEGG" id="lpl:lp_1836"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1548"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_9"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="PhylomeDB" id="Q88W33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1574-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140277" description="Peptide methionine sulfoxide reductase MsrB">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="144" mass="16278" checksum="CAD30DDCC2E59248" modified="2003-06-16" version="1">MDKQQGELRQRLTPEQYAVTQEAATERPFSGEYDNFYQEGIYVDVVSGQALFSSRDKYDAGCGWPSFTKPIDQTNLNEHRDESFGMHRTEVTSTQANSHLGHVFPDGPRDRGGLRYCINSAALKFIPVADLEKAGYGQYQSLFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WQ9</accession>
    <accession>F9UNU2</accession>
    <name>GREA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription elongation factor GreA 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transcript cleavage factor GreA 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">greA2</name>
        <name type="ordered locus">lp_1563</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640314.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889395.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WQ9"/>
    <dbReference type="SMR" id="Q88WQ9"/>
    <dbReference type="STRING" id="220668.lp_1563"/>
    <dbReference type="EnsemblBacteria" id="CCC78881">
        <property type="protein sequence ID" value="CCC78881"/>
        <property type="gene ID" value="lp_1563"/>
    </dbReference>
    <dbReference type="GeneID" id="57025151"/>
    <dbReference type="GeneID" id="66449449"/>
    <dbReference type="KEGG" id="lpl:lp_1563"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1315"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_9"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="PhylomeDB" id="Q88WQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1342-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176935" description="Transcription elongation factor GreA 2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <sequence length="160" mass="17914" checksum="8E9FFB9C4E21582F" modified="2003-06-01" version="1">MAEDKTYPMTEEGKVKLEKELEDLRINQRPEIINRIKIARSYGDLSENSEYESAKNEQSLLENRIKTVEHMLQYAEIIDSDKIDETEVSVGKIVTFKELPDEEPESYTIVGAAEADPMVGKISNDSPIAKGLIGHHVDEEVAINIPAGTMTVKILKVENA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X97</accession>
    <accession>F9UNA1</accession>
    <name>MSCL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mscL</name>
        <name type="ordered locus">lp_1330</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643168.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X97"/>
    <dbReference type="SMR" id="Q88X97"/>
    <dbReference type="STRING" id="220668.lp_1330"/>
    <dbReference type="EnsemblBacteria" id="CCC78690">
        <property type="protein sequence ID" value="CCC78690"/>
        <property type="gene ID" value="lp_1330"/>
    </dbReference>
    <dbReference type="GeneID" id="57024946"/>
    <dbReference type="KEGG" id="lpl:lp_1330"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1122"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_0_0_9"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="PhylomeDB" id="Q88X97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1148-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0407">Ion channel</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000192446" description="Large-conductance mechanosensitive channel">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <sequence length="126" mass="14047" checksum="858AB870DE2F1BA2" modified="2003-06-01" version="1">MIKEFKEFIARGNVIDLAVGVIIGSAFTAIVKSLTDNLINPLIGIFLGKVDLSNLKFSIGDATFKYGSFLNAIINFFIVAIVVFILVKIINKVVKNEPEEPEEEEVDVSAQYLEEIRDLLKEQAKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XC3</accession>
    <accession>F9UN75</accession>
    <name>CPFC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="1">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpfC</name>
        <name type="ordered locus">lp_1296</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101341.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XC3"/>
    <dbReference type="SMR" id="Q88XC3"/>
    <dbReference type="STRING" id="220668.lp_1296"/>
    <dbReference type="EnsemblBacteria" id="CCC78664">
        <property type="protein sequence ID" value="CCC78664"/>
        <property type="gene ID" value="lp_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1296"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1096"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_0_0_9"/>
    <dbReference type="OMA" id="FSYHGVP"/>
    <dbReference type="PhylomeDB" id="Q88XC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1122-MON"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000175153" description="Coproporphyrin III ferrochelatase">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <sequence length="324" mass="36370" checksum="ADB238F15983DBD8" modified="2003-06-01" version="1">MHPGLLLVNLGSPASPRTKDVKAYLQEFLSDPSVIEMPAALWQPLLRGIILPTRSWRSATFYQDSWLPQGSPLIVYSQAICQQVQAALPDWNVRLAMTYGQPDIGATLKAMVADGCEKPIILPLFPQYTQSTHGGIHRQVEATGLPHTFIDSFYDQPTYIHLLATKVWQSYQAHHYDAVIFSYHSIPTAMVRHGDPYQRECEATTKAVLAERPELPADKVITAYQSKFGPMPWLKPYLKNELMQLVELGKRNVLVVTPSFVVDCLETLEEDYVQNYQTFRASGGDRFDLVPPMNKDTGFSQFLADLAIQKQEASNHAITSSSKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY5</accession>
    <accession>F9UMK6</accession>
    <name>RL4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">lp_1034</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888959.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY5"/>
    <dbReference type="SMR" id="Q88XY5"/>
    <dbReference type="STRING" id="220668.lp_1034"/>
    <dbReference type="EnsemblBacteria" id="CCC78445">
        <property type="protein sequence ID" value="CCC78445"/>
        <property type="gene ID" value="lp_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="57024692"/>
    <dbReference type="GeneID" id="66448948"/>
    <dbReference type="KEGG" id="lpl:lp_1034"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.872"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_9"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="PhylomeDB" id="Q88XY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-888-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129229" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="207" mass="22637" checksum="0A15DCC7787236A5" modified="2003-06-01" version="1">MTSVALFKQDGTQNGDVTLNDAVFGVEPNENVVFDAILMQRASMRQGTHAVKNRSARRGGGRKPWRQKGTGRARQGSIRSPQWRKGGIVFGPTPRSYSYKLPKKVMRLALKSVLSQKVLDNSLVAVDSLAFDAPKTKDFVNVLNNLNVDTKTLVLVEEDNEKAALAGRNLPNVKILKAKGVNVLDVANSDKLVVTQKALDQLEEALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY7</accession>
    <accession>F9UMK4</accession>
    <name>RS10_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">lp_1032</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638059.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY7"/>
    <dbReference type="SMR" id="Q88XY7"/>
    <dbReference type="STRING" id="220668.lp_1032"/>
    <dbReference type="EnsemblBacteria" id="CCC78443">
        <property type="protein sequence ID" value="CCC78443"/>
        <property type="gene ID" value="lp_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="49393316"/>
    <dbReference type="GeneID" id="57024690"/>
    <dbReference type="GeneID" id="66448946"/>
    <dbReference type="KEGG" id="lpl:lp_1032"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.870"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_9"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="PhylomeDB" id="Q88XY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-886-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146543" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="102" mass="11736" checksum="E2D5C9D86BADA0DB" modified="2003-06-01" version="1">MAKQKIRIRLKAYEHRILDQSADKIVETAKRTGATISGPIPLPTERTIYTVLRSPHKFKDSREQFEMRTHKRLIDIVNPTPKTVDSLMKLDLPSGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW7</accession>
    <name>F9UKW7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101024.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888496.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0485"/>
    <dbReference type="DNASU" id="1061454"/>
    <dbReference type="EnsemblBacteria" id="CCC77982">
        <property type="protein sequence ID" value="CCC77982"/>
        <property type="gene ID" value="lp_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0485"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.399"/>
    <dbReference type="eggNOG" id="ENOG5033QZ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314112_0_0_9"/>
    <dbReference type="OMA" id="LRTMWTQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-403-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="23598" checksum="6338D3C11E39EB57" modified="2011-10-19" version="1">MQAHIKEKDYFPLSYTITRVLNSGVVMSIEKNEKELKGLKRKLCQFSGKKHAILFNADTGALHGALWGLGYEHDDKVNVKNLNNREKKLLYWLGLELDSSAEAVNIAKLNIDWTNINKIEGSLKQLSEADVICVNFTDLSFGPCTALLTNDDLVAIRAERLIIFGAFDLRTMWTQSETELDVQPGLQMNYRLSPLVGACIKLSILRRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY0</accession>
    <name>F9UKY0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">deoK</name>
        <name evidence="6" type="synonym">rbsK</name>
        <name evidence="8" type="ordered locus">lp_0500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888509.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0500"/>
    <dbReference type="EnsemblBacteria" id="CCC77995">
        <property type="protein sequence ID" value="CCC77995"/>
        <property type="gene ID" value="lp_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0500"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.412"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_9"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="PhylomeDB" id="F9UKY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-416-MON"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="307" mass="32680" checksum="0F3715EAF2FF8E70" modified="2011-10-19" version="1">MADVTVIGSNMIDLTTYIGRMPVEGETIEAPEFNIGYGGKGANQAIAAARLGSDVNFITMVGNDGFGQEQLANYQKNGIRTDGIGIGHQNSGVAPIFVDPSSDNRILIIKGANKELTPAVLDEKQALIKNSKLIVLQQEISLETNYHAIDLAQQFGVPVLLNPAPANKNLNIDYVSKVVFFTPNETELATLTGLPTNNLDEIKVAACDLISRGVENLIITLGHKGALWVTENHAEIVPGMKVKAVDTTGAGDSFIGSFAHYFAQGEAIPDALQHANQYAAMTVMKKGTQKSYPTAAELSDLLAAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ6</accession>
    <name>F9UKZ6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEAD-box ATP-dependent RNA helicase CshA</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rhe1</name>
        <name evidence="6" type="synonym">cshA</name>
        <name evidence="13" type="ordered locus">lp_0520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomerizes, may be a member of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. CshA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0520"/>
    <dbReference type="EnsemblBacteria" id="CCC78011">
        <property type="protein sequence ID" value="CCC78011"/>
        <property type="gene ID" value="lp_0520"/>
    </dbReference>
    <dbReference type="GeneID" id="57024292"/>
    <dbReference type="GeneID" id="66448567"/>
    <dbReference type="KEGG" id="lpl:lp_0520"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.428"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_9"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="PhylomeDB" id="F9UKZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-432-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010501">
        <property type="term" value="P:RNA secondary structure unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01493">
        <property type="entry name" value="DEAD_helicase_CshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030880">
        <property type="entry name" value="DEAD_helicase_CshA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="213"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="528" mass="59039" checksum="383CD92AF838AAE4" modified="2011-10-19" version="1">MKFTELGLSDSLLKAVNRAGYEEATPIQAETIPMVLEGKDVIGQAQTGTGKTAAFALPILQRLDFDNHNIQALVVSPTRELAIQTQEEIFRLGKDERAKVQVVYGGADIRRQIRNLKQNPQVIVGTPGRLLDHIRRGTVKLDHVKMLVLDEADEMLNMGFLEDIESIIKQVPDERQTMLFSATMPPEIKRIGVQFMKEPHHVKIKSKEMTADTVDQYYVKAKEFEKFDIMTRLFDVQAPELTIVFGRTKRRVDELSKGLEARGYNAAGIHGDLSQQRRTQIMRQFKAGKLDILVATDVAARGLDVSGVTHVYNYDIPQDPDSYVHRIGRTGRAGHKGVSLTFVTPNEMEYLRVIEKLTKKRMLPLKPPTESEAFAGQLAAAEANVDSLVAKTSTEKYADQAAELLQKYDATDLVAALLNDLTKDDASAVPVKITPERPLPRHKGGGGNNRRGGYRGGNRNRNNSHGNGRGGYSHNGRNRDRDRNGGRGDRKSNGYKGRSRDDNRSSNRNHDEGRKQSSKRSYTIRTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL31</accession>
    <name>F9UL31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosyl nicotinamide transporter, PnuC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnuC2</name>
        <name evidence="7" type="ordered locus">lp_0559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888560.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0559"/>
    <dbReference type="EnsemblBacteria" id="CCC78046">
        <property type="protein sequence ID" value="CCC78046"/>
        <property type="gene ID" value="lp_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0559"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.464"/>
    <dbReference type="eggNOG" id="COG3201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076589_4_0_9"/>
    <dbReference type="OMA" id="WPIGIAN"/>
    <dbReference type="PhylomeDB" id="F9UL31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-476-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="30588" checksum="011435099E88A075" modified="2011-10-19" version="1">MNQNNHFRLTLSTLLQQCQQDITSLPTAMRAVFSWQRGLNELKTLRRTTKLMMSTMLIVTIIGFILGRDYSLHGWIGLLTGITVVINLILVDQGRLTNYSWGIIACAAWLTTAITNRLIGDIASQSFYLIMQFVGITVWHRKMAAQPDASELTGRKLSKLAGCAWFALAVLVYAIVLHFSKQLNGNQIYLDATLLPLGIVGSVLMVNGYRSQWVAWITLDVINVIIWFNQLKGFSPAAASMLALQLVMLANALYGAYLWFFGQNTQQDKLDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ7</accession>
    <name>F9ULJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    </evidence>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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    </reference>
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    <accession>F9ULS4</accession>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0687"/>
    <dbReference type="EnsemblBacteria" id="CCC78163">
        <property type="protein sequence ID" value="CCC78163"/>
        <property type="gene ID" value="lp_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0687"/>
    <dbReference type="eggNOG" id="ENOG5032FWM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692215_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-597-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="45246" checksum="2E0A43B837BFFCA8" modified="2011-10-19" version="1">MILSELTSMVVENEKGILSRKWVSKLKELDKNLAYKLEEMVRENTANTQVKGSLSEHGASISAGVDGGEKSTAKLVPASYFSQTDELMKTLLQVMKRVRSRYFLFFDDLDEIKLSSLQKVDGENNVTVLAKLLNDFVSALSYVNDKLLDINSKSRVISTLRKDVADQMQFYGSNINKVITDNGINITWFSPMIKDTPQNTPLGKLVLHKIRVSIDSYHDVDDKELFDMVFHKGTKANANPFRFIVNRGFGRPRDVIQYLNSIKEKFPNSTSITYRMAEQVQSEYCSWFYSELQNEISILERHKSISSTIDAIKKNGKVTFNYETLSASIDDNSDEVLNRDGLKKDLKSLFTLGAIGNHQKKKGLKKPIIEYSYRDGTDNPDFSKNFIVHPALKIYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS6</accession>
    <name>F9ULS6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888679.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0689"/>
    <dbReference type="EnsemblBacteria" id="CCC78165">
        <property type="protein sequence ID" value="CCC78165"/>
        <property type="gene ID" value="lp_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0689"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.578"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244020_0_0_9"/>
    <dbReference type="OMA" id="YHVETGQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-599-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388971" evidence="2">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="23137" checksum="3F3130DFC0DE0A4A" modified="2011-10-19" version="1">MHHAKKLVVALTSLLILTGCTTGNQQAANHTSVKTKTVRVEKRTAANKAAWAKARAASRANAASAKALSSNTTQLAIATSQAKRQSEQLKAKHDDAMASSKSASQAAAKSAASEAAAQSRSQSEAQSASAVAAASQSKQAVKASSQAAAQSQQTQTSTATTSRQNNFSGDTDTAQTGRIVGNRNSKIYHVETGQNYRMAGKNAVYFSTEDAARAAGFRKSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS7</accession>
    <name>F9ULS7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="5 12">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mprF</name>
        <name evidence="14" type="ordered locus">lp_0690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="5 12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888680.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0690"/>
    <dbReference type="EnsemblBacteria" id="CCC78166">
        <property type="protein sequence ID" value="CCC78166"/>
        <property type="gene ID" value="lp_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0690"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.579"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_7_1_9"/>
    <dbReference type="PhylomeDB" id="F9ULS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-600-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="13">
        <location>
            <begin position="536"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="867" mass="97815" checksum="944ED0240435E6F2" modified="2011-10-19" version="1">MKATLQKIGTALNKRMGIIKALFVFSVLLFVITEVGKIAKEVSGAQLANALASQSWWHLLSMVVIGIIAVTPMLTYDVMITKFLPNHYSLGYILKAGWITNTFTNIGGFGGVLGASLRANFYNREATKKQIVFAISKIALFLVSGLSLYCMISLVLVYGFGIGNMYGSYWIWLVGGALYFPAIFIFTRVNDSEFFDGLTLGNVVRLLSGSFGEWTGCVLFFLLIGNFMGLPIDFAAVVPLFVIASVVGEVSMVPGGIGSFDVFMIFGLGAVGVSRPDAVAWLLFYRLFYYIIPFAIGLVLFIHDTGHRLNVRLAGIPKQALQRVAQMVLTVFLYFSGFLMLLMSTVPNFAYNNKLFLQFYPYTFFFINQASSIIMAFLLIGVALGTAGRVKKAFWPTVIVLLIAILNTIRWLVVYDAISMKFVIFLIVILALVALSRHAYYRDRLAFSWGQTLWVSCVYVVTFILYTIVGVYNAPQIHHRHAIPEALFFPSQKLWLFGVIGLVLAAMILIIMYRYFASGYNARLRQKMDAARVKQVIETYGGNEISHLAYLNDKLAYYYQVDGVDQLIFLYQQKADKLIIMGEPFGNQAVLQAALEQLLDDADSDGCSLVFYEISEMLTMRLHEMGFDFIKTGEEGHVKLADFSLAGKRLRGERALMNKFTRDHYEFAILQPPFSADVMAELRAVSDSWLAGETEKGFSLGFFDEQYLNQAPVAVVYDPDHRIVAFANIMPQGNHQTTSIDLMRSSKSAPSGIMDTVFVHLFEQARDDGYAYFNMGMAPLSGVGVSRYSFIQEKIAHLIYEYGYQLYGFQGLRSYKEKYVTEWEPKYIAYRKRNSLIFTILQLLQVVNTRVHKSERHRPVWLLKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT3</accession>
    <name>F9ULT3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ordered locus">lp_0696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888686.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0696"/>
    <dbReference type="EnsemblBacteria" id="CCC78172">
        <property type="protein sequence ID" value="CCC78172"/>
        <property type="gene ID" value="lp_0696"/>
    </dbReference>
    <dbReference type="GeneID" id="57024406"/>
    <dbReference type="KEGG" id="lpl:lp_0696"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.585"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_9"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="PhylomeDB" id="F9ULT3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-606-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="19046" checksum="CAB0D7E82A1D026E" modified="2011-10-19" version="1">MTEPTAEDWMQEALHEARMAYLIGEVPIGAVIVHQGEIIGRGHNLREHGQDATMHAEIIAIQEACEYLHSWRLADCQLYVTLEPCLMCSGAIINARLPELYFGARDPKAGAVRSLYQVMDDTRLNHQVTVHERILARPAGEMLENFFRGIRKRKKAAKKARREAAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV7</accession>
    <name>F9ULV7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound protease, CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101144.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888710.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0726"/>
    <dbReference type="MEROPS" id="G05.007"/>
    <dbReference type="EnsemblBacteria" id="CCC78196">
        <property type="protein sequence ID" value="CCC78196"/>
        <property type="gene ID" value="lp_0726"/>
    </dbReference>
    <dbReference type="GeneID" id="57024431"/>
    <dbReference type="KEGG" id="lpl:lp_0726"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.611"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079560_0_1_9"/>
    <dbReference type="OMA" id="QMPIFIV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-631-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="214" mass="23686" checksum="10FDF2CC445B7303" modified="2011-10-19" version="1">MVNRRQSIFILIIYFIIYALPSVLVTAFHQLGAQVFVIQTVDYLVGAILLIWLASRMRTKNVVEKQPSNWFMTFIWGLIGLVLVIIGQVIILKMTALLGQSTASTNTTTLLTVGQQYPAFFLAIIVGAPIMEEIVFRKVIFGNLSAVTGQIGAALISSVLFSFAHADGHFILYAFIGLLFCWLYQHTGRIQTSMTAHILMNASVVLPTLLGLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW2</accession>
    <name>F9ULW2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pstF</name>
        <name evidence="14" type="ordered locus">lp_0733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643949.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888715.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0733"/>
    <dbReference type="EnsemblBacteria" id="CCC78201">
        <property type="protein sequence ID" value="CCC78201"/>
        <property type="gene ID" value="lp_0733"/>
    </dbReference>
    <dbReference type="GeneID" id="57024436"/>
    <dbReference type="KEGG" id="lpl:lp_0733"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.617"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_0_9"/>
    <dbReference type="OMA" id="WPIWAYE"/>
    <dbReference type="PhylomeDB" id="F9ULW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-636-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027136188" description="Phosphate-binding protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="13">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="31480" checksum="FBB7D52A83355E45" modified="2011-10-19" version="1">MKKALTLGALAVTMTILLAGCGSSSATSTKSTSSSSGSSKTTKIVATGSTALQPLVEQAGQAYQNEHANVTINVQGGGSGAGLSQVAKGSVNIGNSDLFAQEQKGLDAKGLVDHKVAVVGMAPVINKDAGVTNISKEQLIKIFQGKITNWKDVGGKDEKITVVNRAQGSGTRATFEKWGLDNAKVATSQEQDSNGTVQKIVSTTPGAISYLAFSYVKSDVQALSIDNVKPTEANVATNKWKIWAYEHMYTKGQPTGELKNFLTYMTSKAVQGSLVEKLGYIPLTSMKVDRGQSGAITNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM65</accession>
    <name>F9UM65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate oxidase</fullName>
            <ecNumber evidence="6">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pox2</name>
        <name evidence="6" type="ordered locus">lp_0852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888818.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0852"/>
    <dbReference type="EnsemblBacteria" id="CCC78304">
        <property type="protein sequence ID" value="CCC78304"/>
        <property type="gene ID" value="lp_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0852"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.724"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_9"/>
    <dbReference type="OMA" id="IGVKFGC"/>
    <dbReference type="PhylomeDB" id="F9UM65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-740-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="383"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="587" mass="63640" checksum="CC7D80FF82561FC3" modified="2011-10-19" version="1">MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAASADAKFTGKIGVSFGSAGPGATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDETPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVVIIPENLSAEEIDYQPVSTPNTVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPATGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSFDIGKMVPIDYAVISDAQAYLQAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDGLAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQEQRFALSGLFATMGFGLPAGMAGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQHLYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDDPIGTAYMPLDPELYGQAEVDAYAKANHIDIKEQPSLGALLRAQGDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI6</accession>
    <name>F9UMI6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase, PAP2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1001"/>
    <dbReference type="EnsemblBacteria" id="CCC78425">
        <property type="protein sequence ID" value="CCC78425"/>
        <property type="gene ID" value="lp_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1001"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.848"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_3_3_9"/>
    <dbReference type="OMA" id="CCSLALY"/>
    <dbReference type="PhylomeDB" id="F9UMI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-861-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="25093" checksum="119FC4ADF9C435C6" modified="2011-10-19" version="1">MIDKSRSRPIKFVIGVILFAYLSYFISDGAVGIDLLDVALTSLVQISNSGIWTVFYKVIAWLASPGMDILWIVILAFLMYGFKYKIQAFWTLAYMVGAMALGFIVKHIIGRARPIGHLAQDTGYSYPSGHVLGTFVLVSVIIMLIVPELPSYRMAMIVKWVSVVWLVLVIFSRIYLNAHYPTDTIGAVLLAWSWSQIMQWFYVFWAPGLLKWPLFYRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT0</accession>
    <name>F9UMT0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78519">
        <property type="protein sequence ID" value="CCC78519"/>
        <property type="gene ID" value="lp_1123"/>
    </dbReference>
    <dbReference type="GeneID" id="58789800"/>
    <dbReference type="KEGG" id="lpl:lp_1123"/>
    <dbReference type="eggNOG" id="ENOG5030A6V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207759_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-962-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="58" mass="6480" checksum="F0F97D21BAB7D8BA" modified="2011-10-19" version="1">MDIGTQVTFILEGQNYTGTIAKSYTNSYLITFTSPDPAIVDKYHNKVIISQKQVQAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT4</accession>
    <name>F9UMT4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome D ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydC</name>
        <name evidence="10" type="ordered locus">lp_1128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1128"/>
    <dbReference type="EnsemblBacteria" id="CCC78523">
        <property type="protein sequence ID" value="CCC78523"/>
        <property type="gene ID" value="lp_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1128"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.953"/>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="OMA" id="FPLNWAA"/>
    <dbReference type="PhylomeDB" id="F9UMT4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-966-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="577" mass="64265" checksum="2A2AACBF65F15AA0" modified="2011-10-19" version="1">MFDPALFKLPGMRRAATILGLLAIVEGICIVFQAYYLSVAIVGLWHLHSLASISQPMLWFALAWVGRQLLVVIKNRVMYPLVEQTTGDLRRKVMQKLYRLGPSYVAKTGTGNVVTTALEGIDKVQTYLMLVVIKVIDMMVIPWIILIYIAWLRWREALFLLAIFPLIILFMIILGYAAQAKADKQYVGYQRMSNHFVDTLRGLPTLKQLGLSKRYADNVYQVSEGYRKQTMAVIKIAMLSTFALDFFTTLSIAVVAVFLGFGLINGTITLLPALVILVLSPDYFLPLRTFANDYHATLNGKNAFADVQKMLALPVPTERQQLGTQPVQWQSDSTLSLHDVDFKYDDDQLALKHINIDVHGYQRIGIIGASGSGKSTLINLLGGFLTPVADQGKIQVNGQTVSHLSQDAWQQSFFYIPQNPYLFHATLAENIAFYQPDASRQAIERAAENAGLTAWIATLPAGLDTAIGEGSRGVSGGQAQRIALARAFLDDSRRVLLFDEPTAHLDIETEAELKTTILPVLDNHLVFFATHRLHWINQMDYVLVMDHGEIVEQGTPTELAAHDGAYVRLRDEMVGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMU7</accession>
    <name>F9UMU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, pheromone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1146"/>
    <dbReference type="EnsemblBacteria" id="CCC78536">
        <property type="protein sequence ID" value="CCC78536"/>
        <property type="gene ID" value="lp_1146"/>
    </dbReference>
    <dbReference type="GeneID" id="57024782"/>
    <dbReference type="KEGG" id="lpl:lp_1146"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.967"/>
    <dbReference type="eggNOG" id="COG4851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052482_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-978-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011426">
        <property type="entry name" value="CamS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07537">
        <property type="entry name" value="CamS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012509">
        <property type="entry name" value="CamS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394386" evidence="2">
        <location>
            <begin position="32"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="42612" checksum="8493CA7F11C784AD" modified="2011-10-19" version="1">MNVKRIRTIGLVAVAAIVLAACGNLKNSSFGSTSSSTTTTGTKTTTTTGTADSEFYQGVIKNGRYRTSKSRGVVVSQNDNVMNLKSFESGLLDVSKKVFPTSKYVFQEGQYLSSSTVENWLGRKSSSNSEGLNPENNGKKDPNTRNPIYLQQLEEQDYMVQNGSKLSLGGVTIGLGMNSVDYYTKVEYGATYETDISTTELTAQGKKMANTVLQRLRQRSALKNVPIVLALYKQSSNDSLVGGDMIAYAVSKNGSTSISNWTSLNWKNYVFPATSESKNSGANSNDESDFSQFKSHVQNFFPNLSGVTANAHYKDKSLSKLSVNITTKFYSETEIISFTQYLATAAKRYLPSGVPVEITVKSANGDIQSFLARTAKGSSYYTHVFSDQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV7</accession>
    <name>F9UMV7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889060.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1157"/>
    <dbReference type="DNASU" id="1063211"/>
    <dbReference type="EnsemblBacteria" id="CCC78546">
        <property type="protein sequence ID" value="CCC78546"/>
        <property type="gene ID" value="lp_1157"/>
    </dbReference>
    <dbReference type="GeneID" id="57024792"/>
    <dbReference type="KEGG" id="lpl:lp_1157"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.977"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_4_9"/>
    <dbReference type="OMA" id="VPFIHRS"/>
    <dbReference type="PhylomeDB" id="F9UMV7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-988-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="132"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="31726" checksum="9AFEF385EDDFC089" modified="2011-10-19" version="1">MSTQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATVSRFVKRISFSSFRDFSRELTAAEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQTSQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHKFVRTGIPCAHNSDYDMQLMQAAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAEEINYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW4</accession>
    <name>F9UMW4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts14C</name>
        <name evidence="11" type="ordered locus">lp_1164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1164"/>
    <dbReference type="EnsemblBacteria" id="CCC78553">
        <property type="protein sequence ID" value="CCC78553"/>
        <property type="gene ID" value="lp_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1164"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.984"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_2_9"/>
    <dbReference type="OMA" id="HTIRNTQ"/>
    <dbReference type="PhylomeDB" id="F9UMW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-996-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="5"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="435" mass="47684" checksum="6AA0F24B900D260F" modified="2011-10-19" version="1">MLKHVQNSLLTFERVVERQRYWRALRDTLTLLFPFALVGAYVSFMNQAIFQRNGFLNHIYYLSHWLPGFKHLATYTTMLNLSINGILAVIAAFSAANFVARSAQRDNLLAGLTAAISFIMLNINYNFFSTQGQPAGSRFLEDNLGTQGIFLALLVGLLTGWLFSHLTRYPHIHQEIETQTHLLARAHANWLPIVAALLVFSAIGYGVSFVSKGGLNGLFYAVFTLPFSNPGASLLAIIGVASLSNLYWLIGIIGPVDFSGNSTTSTVQNLEYALQHGSAWGAPNPVTLHTLFDAFANVGGPGMTLALLIAILWRSRNRNYRTVAKTSALPVLFNINQPLLVGLPIAYSPILAIPFLLAPLASMVITWCALKLQWMPPVVYPVGRTMPGFLTGWLGTGGDWRAFIVSLINIAVATAVYLPFVLLANQVEEEAQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY6</accession>
    <name>F9UMY6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbC</name>
        <name evidence="4" type="ordered locus">lp_1188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644155.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1188"/>
    <dbReference type="EnsemblBacteria" id="CCC78575">
        <property type="protein sequence ID" value="CCC78575"/>
        <property type="gene ID" value="lp_1188"/>
    </dbReference>
    <dbReference type="GeneID" id="57024824"/>
    <dbReference type="KEGG" id="lpl:lp_1188"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1006"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UMY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1018-MON"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="193" mass="21826" checksum="48572F82A8BB016B" modified="2011-10-19" version="1">MGKLKVTTTKLQDVKIIEPAVFGDKRGFFTETYSDRDFKEAGIDFDFIQDNQSLSAEAGVLRGLHFQRGKAAQTKLIRVVTGAVLDVIVDVRAGSPTYGEWEGYIISESNHRQLLVPRGFAHGFVTLTDNVNFLYKCDNYYNAEADGGITFMDKDLNINWPIDYDQAITSDKDAKQQTFKEFEQNNPFVYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN03</accession>
    <name>F9UN03_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligosaccharide transporter (Flippase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cps2I</name>
        <name evidence="6" type="ordered locus">lp_1205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
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                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    <accession>F9UN25</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="266"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="321"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="473" mass="53400" checksum="ED653D1A3E4686F9" modified="2011-10-19" version="1">MRIIRNYFYTAGYNLLILLTPLLTVPYISRVLGPTGVGINATTNSIITYFLLFGTVGITIYGNREIAFIRDNRGQRSQTFWEIEILQLLTISCAYLAFLVFLFFEHQLQIYFFYQSFYIIAGAVDISWYFMGLEDFKKTVLRNMLVKIASVIAIFAFVKTRQDTGIYILILAGSQVLGNLTLWPYLRHSVERPNWRQLNLFRHLRPSLALFVPQIATTVYLALNKTMLWQMDSLTAAGFYDYSDKLIKLVLALVTATGTVMLPHIANLFMKQQLERVKQYLYMSFDFVLAIAIPMALGVAAVATTLAPLFFGRAFGAVDRLLMIEAPVIILIGMSNVLGQQFLLPTKQTKTYTISVTIGALVNIACNIPLIWFWGVAGAMCATLISEVCVTGYQLFITRHVLHAQSLFTGIWKYTLAGGLMFTFVFRLNVTMTASYLNLCLQIGVGVLLYLGLILLLQPPVLRNAIKLRNNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN44</accession>
    <name>F9UN44_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione reductase</fullName>
            <ecNumber evidence="5">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gshR2</name>
        <name evidence="5" type="ordered locus">lp_1253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101333.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1253"/>
    <dbReference type="EnsemblBacteria" id="CCC78633">
        <property type="protein sequence ID" value="CCC78633"/>
        <property type="gene ID" value="lp_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1253"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1063"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_0_9"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="PhylomeDB" id="F9UN44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1074-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="440" mass="47586" checksum="3337AC0492936B36" modified="2011-10-19" version="1">MSEKFDVVYLGSGHGTFDGAIPLAARGKKVAVIEADSIGGTCPNRGCNAKITLDQPVALKNQVANFQGYGLRGEPTIDWQANFDHERDVIAGLPDMIAGLMTSAGVTLINGRGTFVDDHTIQVADKTYTADKIVIATGQHPHRLDIPGTELAHDSNDFLNLTTLPHHITVIGAGYIGLEFANMALTAGSQVTLLMRGDQALRQFHQPFVERLLAILVEQGLVLKREWVPTAIKSTGDHFEVLSADDKVTTDWILDATGRQPNTANLGLEKIGVDYTAAGITVDDHLQTSVAGIYASGDVLAKDQPKLTPTAIFESQYLTHLFMGDTNAPIKYPAIPSVVFTSPRLAQVGTLPTSDTHDIKVTVNDLKDDWFRQTTRDVTGHNLLVTDDQHRLIGAAELGEQAENTINTLLPAIQYQLTPAQREQLVTLFPSIGAAVWSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN51</accession>
    <name>F9UN51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">oppA</name>
        <name evidence="11" type="ordered locus">lp_1261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101336.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889154.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1261"/>
    <dbReference type="EnsemblBacteria" id="CCC78640">
        <property type="protein sequence ID" value="CCC78640"/>
        <property type="gene ID" value="lp_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1261"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1071"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="SSWGDPQ"/>
    <dbReference type="PhylomeDB" id="F9UN51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1081-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394260" evidence="9">
        <location>
            <begin position="31"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="10">
        <location>
            <begin position="76"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="547" mass="60334" checksum="9F8490C374AF7825" modified="2011-10-19" version="1">MNFKTAAKVTVVAGASVLFLAACGSSKSSSSSKQTANWTESAELPTMDISKSTDVVSSNALNNTNEGLYRLGKNGKVTPGIAKSTKVTNGGKTYTFTLRKNAKWSNGDKVTAKDFVYGWQRTVNPKTASQYAYLYSGIKNADAIVNGKKPVSSLGIKADGDYKLTVTLDKPIAYFDKLMGFVNFFPQNEKVVKKYGSKYGTSSKAMVYNGPYKMTGWTGTNLSWTLKKNNDYWDKKAVKMDSIKYQVVKDPSTGLNLFNSNKLDFTTLSNEQVKNYKNDKNYLVRKTASTFYVEFNRKDSDKTLAKAFQNKKIRQALSLAINRKSYVNNTLGNGSTVSKGYVSEDLAKNPTTGKDFTTDAAVPSAVDYNLTKAKKLWKEGLKEIGETKLNIKLLSDDTDAGKKATEFIQGGWEKLPGLTVTNQNVPFKTRLQRSQNGNFDTVISAWNADFTDPISFLSLFTSDNSYNNGKYDSAAYDDAVKKAEGADANNKTARWADMVAAEKQLMNDQGVIPIYQQASATLTRSNLKGIIYNTAGSNYNFKYMSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN60</accession>
    <name>F9UN60_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 15">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ptsI</name>
        <name evidence="22" type="ordered locus">lp_1274</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 15"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646541.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889163.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UN60"/>
    <dbReference type="STRING" id="220668.lp_1274"/>
    <dbReference type="EnsemblBacteria" id="CCC78649">
        <property type="protein sequence ID" value="CCC78649"/>
        <property type="gene ID" value="lp_1274"/>
    </dbReference>
    <dbReference type="GeneID" id="66449147"/>
    <dbReference type="KEGG" id="lpl:lp_1274"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1081"/>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_9"/>
    <dbReference type="OMA" id="CNAEWAL"/>
    <dbReference type="PhylomeDB" id="F9UN60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1091-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="15 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="21">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="19">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="20">
        <location>
            <begin position="253"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="17">
        <location>
            <begin position="457"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="16">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCC78649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="576" mass="63111" checksum="94CEB002F5A1EF93" modified="2011-10-19" version="1">MAEKVLKGIAASDGVAIAKAYMLVDPDLSFEKTTVSDTDAEVARLHDAFDASKAELKVIKDKAVENLGEEEAEVFEAHITILSDPEMLGQIEGKIKDDKVNAEEALKEVTDTFISMFEAMTDNAYMQERAGDIRDVTKRVLSHLLGVTLPSPALIDSEVIVVAHDLTPSDTAQLDRKYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSESATTDIKEGDTVVLDGINGDALVAPTDAEVADYQQKAKDFVAQKAEWAKLKNEATVSKDGKHFELASNIGTPDDMDGVLDAGSEAIGLFRSEFLYMNSSELPDEDTQFEAYKKVVEGMNGKPVIVRTMDIGGDKELPYLPLPDEMNPFLGYRAIRISLDRDDIFRTQLRALLRASHYGQLRIMFPMIATLDEFRKAKAIFEEEKAKLVAAGTPVADDIKLGIMIEIPAAAILADQFAKEVDFFSIGTNDLIQYSFAADRGNEQVSYLYQPYNPSLLRLIKHVIDAAHANGRFTGMCGEVAGDQIAVPLLMGLGLDEFSMSSTSVLKTRSLMKKLDTKEMAKLADKALNECVTNEEVKELVEKNVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN84</accession>
    <name>F9UN84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE2</name>
        <name evidence="2" type="ordered locus">lp_1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101348.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889187.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1311"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78673">
        <property type="protein sequence ID" value="CCC78673"/>
        <property type="gene ID" value="lp_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1311"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1105"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_21_0_9"/>
    <dbReference type="OMA" id="MFYFINE"/>
    <dbReference type="PhylomeDB" id="F9UN84"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1131-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="502" mass="57878" checksum="53F4B27D0A985B86" modified="2011-10-19" version="1">MFYFINEYILGKNSSVEHAAINRVKLFNHYKAPAQIVTKMYDRLLHQTMGTFQLANQQVLNMFDYFQQTTDVPTKVLHTDDMHLPVEYAVEVGANFSKIFNGDEHVSNVGFIPGTIGRVFYQEFFDNQGNLSSTDLWDWRGFKSSTQYFGQNGKLVLERFYNLQGETVIEQYYVPDTNGNPLASRLILKNYRDQAERFFQDANHLFRFFLAELSHLDKQTTTFISDRPGTSVKPLLELQDDSHKYVTVPIYQAKDINDPIHSPLDGFLTPAFDNLQHFDGFITATESQAQHLRTRFPKAKVTVLPTVTTSPLAQSKLRPITARPKQLLYVGRLAPDRQLDQLIRTIALVKQQVKEIQCDFYGYGDPEYLKTLNKLVEELKLTNNVHLLDYHPDLETRYDDYQLLLNTDIVDGGPMSMPEAMSHGIPVISYRFNYGPKDWIDDGHDGFIVDPGNQLALRDRVIELMTDTKKLTAFSEAAFKKLHTSQTDLKVWHRWQQLLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN98</accession>
    <name>F9UN98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ugpB</name>
        <name evidence="1" type="ordered locus">lp_1327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889201.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1327"/>
    <dbReference type="EnsemblBacteria" id="CCC78687">
        <property type="protein sequence ID" value="CCC78687"/>
        <property type="gene ID" value="lp_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1327"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1119"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_9"/>
    <dbReference type="OMA" id="ESFSAWH"/>
    <dbReference type="PhylomeDB" id="F9UN98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1145-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="49509" checksum="CBA76DB08023AA24" modified="2011-10-19" version="1">MMKITRKWQWLAGMMVVLLVVGGVAYSRTRVHADSSRIKVVFWHEMKGPGQQAIDAYVKAFNHQQSKYEVVAEFEGGYNGVIQKILNTHGTAASPALFQSMDISTSQMYHSGFTTPMQKFIDRDHYDADQIIPGAKAIVMRDNQLLAMPFNASQTALYYNKRVLRQYGITPPPVDPTYDDITRVAKAIHDKSHGKVKGMTMEAYSWLFEQLVANAGVPVANHDNGHTGNATKVDFTSPAAINAMKWVKENIDYGDFMNFGSGGNAAANEAASFLAGHLGIFMQSSANTGQLYQVLKNDLGVTYFPRPNGQRANGIAVGGAALWIANDKPSAVQDGAWEFTKFLASAQTQADWQAKTGYLAVNKGAKDEPTLKKLFKKSPVLEVSGNQMLRTKPNNTNSGVFVDGWVPARTAIQTAMQQIFAGQDIRQSLQTAENTYNKVLESNNRANGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB4</accession>
    <name>F9UNB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101366.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1350"/>
    <dbReference type="EnsemblBacteria" id="CCC78703">
        <property type="protein sequence ID" value="CCC78703"/>
        <property type="gene ID" value="lp_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1350"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1135"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_9"/>
    <dbReference type="OMA" id="IGFESPN"/>
    <dbReference type="PhylomeDB" id="F9UNB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1161-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="371" mass="41680" checksum="54F69CA96F611278" modified="2011-10-19" version="1">MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIVPFTNVHPSGIGFESPNAFHEENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYDLMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLDGVEIHGANGWLIQQFVSETYNQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLALVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQGLKAFNTGWADLLAVGGSVELNPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLAGNAMFPKVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF1</accession>
    <name>F9UNF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1397"/>
    <dbReference type="EnsemblBacteria" id="CCC78740">
        <property type="protein sequence ID" value="CCC78740"/>
        <property type="gene ID" value="lp_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1397"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1171"/>
    <dbReference type="eggNOG" id="ENOG50336JS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130305_0_0_9"/>
    <dbReference type="OMA" id="DYHRHET"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1201-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021701">
        <property type="entry name" value="DUF3284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11687">
        <property type="entry name" value="DUF3284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17845" checksum="AAFA32C1470EE31A" modified="2011-10-19" version="1">MSRYNRIMKIIRTLAVTNTEFYDWLEKQLLIEIQAATGEILTATSIKKGLTYTKTTAKTAAQIKITIDDYQRGIKYQMTAISPLDTVTVTYSTIAEGTKTTVTFLEDVDSYRPQQHHWLLRNFSQALLLGRMSDKLLQLEQQIIAHRTTTCKPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF9</accession>
    <name>F9UNF9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase (PLP-dependent) with N-terminal regulator domain, GntR family</fullName>
            <ecNumber evidence="4">2.6.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1407"/>
    <dbReference type="EnsemblBacteria" id="CCC78748">
        <property type="protein sequence ID" value="CCC78748"/>
        <property type="gene ID" value="lp_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1407"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1180"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_9"/>
    <dbReference type="OMA" id="GGCFNNY"/>
    <dbReference type="PhylomeDB" id="F9UNF9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1209-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="483" mass="54146" checksum="613D5F42CED9EFB0" modified="2011-10-19" version="1">MAILTINWQPNKQVSTPIYQQITNYFQEQIAKGNWAVGAKLPAQRKLAEQFGVNRSTLITALDELMAVGLITSNPGSGMVISGNHWSSLLAEHVNWSQYVKAGQFKPNSHALQKINQFETDAVIRLSTGEPAPEQFPRPLFQRAFAHLGEQLTSLNYTEPAGILALRQQIARHLEKVGIHTHPENILITSGSLQALQLVSMSLFPKDATIYTEAPTYVKSLHVFQSAHTHLAGIPMDSQGLAYWQMNAPIQGHHAILYTIPTFNNPTGIVMSAERRQQVLQTAQEHRLPILEDAAYQDVWFDQQPPQPLKALDKTGNVIYFGSISKSLAPGLRIGWTVAAKPVIDRLTDVRMQTDYGASSLSQLVLAEILADPEYETYQADFRSVLVKKAAAAEQILHHYWDDFATWQTPTGGFYLWVRLADNINIPKLFDLATAHNVLFNPGSIYDFQPNQYIRLSFSYESSDRFEQGIKILTDLIHANFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH2</accession>
    <name>F9UNH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1424"/>
    <dbReference type="EnsemblBacteria" id="CCC78761">
        <property type="protein sequence ID" value="CCC78761"/>
        <property type="gene ID" value="lp_1424"/>
    </dbReference>
    <dbReference type="GeneID" id="57025052"/>
    <dbReference type="KEGG" id="lpl:lp_1424"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1194"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_0_9"/>
    <dbReference type="OMA" id="SENMIFT"/>
    <dbReference type="PhylomeDB" id="F9UNH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1222-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
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        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="204" mass="22925" checksum="43A8E6CDD72A6100" modified="2011-10-19" version="1">MKFVGIVGTNATKSTNRQLLQYMQRHFQQQATIEICEIKDLPAFNEPEDRTAPVAIQQLSDKITAADGVIFATPEYDHSIPAVLKSAIEWLSYTTRPLINKPVMIVGASNGSLGTSRAQAHLRQILEAPELKALVMPNIEYLLGRSLQAFDDQGDLTYPDKVQELDNAFGEFIDFVDLTNKIMPSSQFFEKSKQFSWRQVTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNP2</accession>
    <name>F9UNP2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101449.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889345.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1505"/>
    <dbReference type="DNASU" id="1063380"/>
    <dbReference type="EnsemblBacteria" id="CCC78831">
        <property type="protein sequence ID" value="CCC78831"/>
        <property type="gene ID" value="lp_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="66449391"/>
    <dbReference type="KEGG" id="lpl:lp_1505"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1265"/>
    <dbReference type="eggNOG" id="ENOG5030AYN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120912_0_0_9"/>
    <dbReference type="OMA" id="HANIMKM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1292-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="21465" checksum="45D985CA5DE629BF" modified="2011-10-19" version="1">MSRMMKMGTGTLRVILWFASILIWFSIFVPIEYLVNYFSGETTNYILHSDDFMMPIKTHVASTNAIASFPSGLYTTLMIIGYILMLVGVFITIQAVSAIVRHIQEQDYFSTENSQQMNRIVKGQIWILGSSLLMACANQLTVSWLYRISQFGLGWDNLLSAFVDLIIFALIAMIYTRAVNMKTESDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS6</accession>
    <name>F9UNS6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombination factor protein RarA ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rarA</name>
        <name evidence="3" type="ordered locus">lp_1543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889379.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1543"/>
    <dbReference type="EnsemblBacteria" id="CCC78865">
        <property type="protein sequence ID" value="CCC78865"/>
        <property type="gene ID" value="lp_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1543"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1299"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_9"/>
    <dbReference type="OMA" id="ACEFVGM"/>
    <dbReference type="PhylomeDB" id="F9UNS6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1326-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="458" mass="50887" checksum="8CF0A9E741126F26" modified="2011-10-19" version="1">MRQESLFNPDKSSSSPLAYRVRPVTLADFKGQEHLLGPGKLLRQLIAEDQLPSLIFWGPPGVGKTTLAEIIAQQTQSHFITFSAVTSGIKEIRQIMDEAEANRDFGEKTIVFIDEIHRFNKAQQDAFLPYVERGSITLIGATTENPSFEINAALLSRCKVLVLKALTPDALEAVLQGALQNPKGFPDLEITMQPDTLRLIAEFANGDARMALNTLEMAVLNGDRDGKHVTITTAGLSQLINTKSLRYDKHGEEHYNIISALHKSMRNSDVDAAIYWLMRMLAGGEDPLYIARRLIRFASEDIGLADRQALPLTVAVFQACQLIGMPECDVNLTEAVTYLALAPKSNALYAAKSAAQADIKATGNLPVPLQIRNAPTKLMKDLGYGSDYQYAHDTAAKLTTMTTMPPELKQHRYYEPTSQGQEKAWQQRLAAIRSGTSNIRKPNRQMMRHKDCNLMRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY5</accession>
    <name>F9UNY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="12855" checksum="022587ABC71463DA" modified="2011-10-19" version="1">MQNQQSNLKLISKNLHASYRQFMDDFTAAPTVVAPLLPMMPAFQRDLFLAQAHTEHYQIMLQMQPQLTESRPYNIHGVLKTLASGQLVLVNRQLHLTHLFDPDAIRYIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP25</accession>
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        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101493.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889478.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1659"/>
    <dbReference type="EnsemblBacteria" id="CCC78964">
        <property type="protein sequence ID" value="CCC78964"/>
        <property type="gene ID" value="lp_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1659"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1400"/>
    <dbReference type="eggNOG" id="COG1335">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_5_9"/>
    <dbReference type="OMA" id="KTRPSCF"/>
    <dbReference type="PhylomeDB" id="F9UP25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1427-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC78964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="19805" checksum="9708CC356E5CFE71" modified="2011-10-19" version="1">MADVLIIIDMQVGVCRGSQPVTNLATVIAGIQQRITSYRAQNKPIVFVQHHDADLVTGSADWQMIPELPIEATDIVVQKTHANAFYHTDLQAQLTAIGCQTLEICGAQVEFCVDTTVKMAHGLGYHLEMVRGLTTTTANSMMSAQQTIDFYQDRIWNHRFLTLVTASGRIDDLLEKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP76</accession>
    <name>F9UP76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium/ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_1716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889529.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1716"/>
    <dbReference type="EnsemblBacteria" id="CCC79015">
        <property type="protein sequence ID" value="CCC79015"/>
        <property type="gene ID" value="lp_1716"/>
    </dbReference>
    <dbReference type="GeneID" id="57025344"/>
    <dbReference type="KEGG" id="lpl:lp_1716"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1450"/>
    <dbReference type="eggNOG" id="COG1340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011722_6_2_9"/>
    <dbReference type="OMA" id="ANIAAWF"/>
    <dbReference type="PhylomeDB" id="F9UP76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1478-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="198"/>
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    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
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            <end position="207"/>
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    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="29691" checksum="8A84D6A13B7F50DC" modified="2011-10-19" version="1">METEQRQQRRIAVYHLIVTLLTLWSAVNVILLSFHIGDWHVETRISNGLLVMFAVDYFVRLIRSRDRKTFLIHSAFDLMGIIPMHPVFALFRLGRLARMVQYHHLFWKLGLDGKWTHDFHRFIYSTGFIYLFSISIAIIVLSALLFSVFEHQSLSDSLWWAITTATTVGYGDDTPHTAVGKVIAVGLMFGGIGFIGLLTSTITDFFTTQASQNVTIEEPQHDDELRQLLIKIDTLTTKVDHLQNQVKRLEKSGYKKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG7</accession>
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        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1824</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101566.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889620.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1824"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79106">
        <property type="protein sequence ID" value="CCC79106"/>
        <property type="gene ID" value="lp_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1824"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1542"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_3_1_9"/>
    <dbReference type="OMA" id="ALWLYAY"/>
    <dbReference type="PhylomeDB" id="F9UPG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1569-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="435" mass="49431" checksum="765C74EE81AA22E2" modified="2011-10-19" version="1">MMIIIRVAIMISVVFYLYFIINLLLINHYREPIQSYEKGPTPYELFLVIPVLNEEHVISRTITQLTESLEQLPPTVHAQIIAVDDDSTDHSLLLLTQSSSRFLQILHRTGNQRAGKGAVLNTAVQYIHKTLALKSDPQRTIVGVLDADAFMNTADLTRVLAHFEQEPQLAMIQTSVNIYNQPNWLTKMQNFEFMGVNNATQQLRNRLGQGIASGNGQFVRLDLALQNPWGNSLLEDLEFTLRTWLLGGTRTAFDHTLVVQQEAVEQLRPFFRQRVRWCQGAVQCMRYLPALWRSGRLNHFQKLDTTFWILMPISGCIVPLTSLITLVVLVSRSLQHWQVGWHHLAIGTLLVIAFSACLVLAALYQRNCAVVKQPVGFLDALKQSLTFQAFLLIISLTPYVAIYRQLRGQTGWAKTHHGVTTRVAKYPDTGLKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPK1</accession>
    <name>F9UPK1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein, ChvD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889654.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1871"/>
    <dbReference type="EnsemblBacteria" id="CCC79140">
        <property type="protein sequence ID" value="CCC79140"/>
        <property type="gene ID" value="lp_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1871"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1577"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="PhylomeDB" id="F9UPK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1602-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="578"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="636" mass="71369" checksum="3CF35C8D41A521FE" modified="2011-10-19" version="1">MQTLRAENLTRTYGEKTLFHDISFIVNEHDRIGVIGVNGSGKTNLLDVLAGITAPEAGQLVMPKNYTIGYLKQKPELDQNLTVIDAVLAGSQQVFRTIRHYEQTLAAYADHPEDQATQKAYVAAEDRMNQEDAWTAESDVKTILTQLHITDLTQTVSQMSGGQQKRVGLAQVLIQSPDLLLLDEPTNHLDFDSIEWLESYLASYKGALIVVTHDRYFLDQVANQMFELSFGELHKYTGNYQDFVQAKAERVARDVLAEHKQQQLYKKELAWMRAGAPARSTKQQGRINRFNDLKDNLNTLQVDNDVDISLGQQRLGKKVIELKDASLQFDRQTILDHFSMLIQANDRIGITGINGAGKSSLLNVIAGRLPLDSGTVTIGETVKMAYYTQQTEPIPGDKRIINYLQDVGETVLNKQGEHVSVTELLEEFLFPRSMHGTLIRKLSGGEQRRLYLLKLLMQQPNVLLLDEPTNDLDIGTLTVLENYLDDFAGTVITVSHDRYFLDKVGTKLLIFDGQGHIERYSGRFSSYLKDQKDAAKPAAKATATKTTAKPVTDDSTAPLAKKAKVKLTYAEQLEYDKIEGVIEQLDSHKSEIEAAMAANASDYGKLADLQKELTKTEQTIDEKMDRWDYLSQYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP9</accession>
    <name>F9UPP9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase (RNAP)-binding regulatory protein, arsenate reductase (ArsC) family, Spx subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spx2</name>
        <name evidence="4" type="ordered locus">lp_1928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640632.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889702.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1928"/>
    <dbReference type="EnsemblBacteria" id="CCC79188">
        <property type="protein sequence ID" value="CCC79188"/>
        <property type="gene ID" value="lp_1928"/>
    </dbReference>
    <dbReference type="GeneID" id="57025514"/>
    <dbReference type="GeneID" id="66449746"/>
    <dbReference type="KEGG" id="lpl:lp_1928"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1625"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_9"/>
    <dbReference type="OMA" id="ARQCFRD"/>
    <dbReference type="PhylomeDB" id="F9UPP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1650-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="133" mass="15379" checksum="8D7AE9FB7776EA77" modified="2011-10-19" version="1">MIKLFTQAGCNSSRKARQWFRDHDIAFEEKNFSSAAPTVSELKQILCLTENGLEDIISTRSQSYPAIADKLPDMSFNETLRLLCEQPQLLRRPIIVGRNKLQVGFNDDDIRQFIPRHIRRLNFQQTLVGLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX9</accession>
    <name>F9UPX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-Ala-teichoic acid biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dltX</name>
        <name evidence="2" type="ordered locus">lp_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640708.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889782.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2020"/>
    <dbReference type="EnsemblBacteria" id="CCC79268">
        <property type="protein sequence ID" value="CCC79268"/>
        <property type="gene ID" value="lp_2020"/>
    </dbReference>
    <dbReference type="GeneID" id="57025576"/>
    <dbReference type="GeneID" id="66449803"/>
    <dbReference type="KEGG" id="lpl:lp_2020"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1707"/>
    <dbReference type="eggNOG" id="ENOG5030APB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200243_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1730-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021008">
        <property type="entry name" value="DUF3687"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12459">
        <property type="entry name" value="DUF3687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="49" mass="5838" checksum="2257D71DE8B99959" modified="2011-10-19" version="1">MFAKLKSWFQRPVVQFIALTVFYFAVMLALVYLYGYSGINQAKFIYNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ21</accession>
    <name>F9UQ21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mvaS</name>
        <name evidence="6" type="ordered locus">lp_2067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889824.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2067"/>
    <dbReference type="EnsemblBacteria" id="CCC79310">
        <property type="protein sequence ID" value="CCC79310"/>
        <property type="gene ID" value="lp_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2067"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1752"/>
    <dbReference type="eggNOG" id="COG3425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_3_2_9"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="PhylomeDB" id="F9UQ21"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1770-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011554">
        <property type="entry name" value="HMG_CoA_synthase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01835">
        <property type="entry name" value="HMG-CoA-S_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="5">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611554-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611554-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="389" mass="42817" checksum="4B36A6A7D104F219" modified="2011-10-19" version="1">MKVGIDKLHFATSHLYVDMAELATARQAEPDKYLIGIGQSKMAVIPPSQDAVTLAANAAAPMLTATDIAAIDLLVVGTESGIDNSKASAIYVAKLLGLSQRVRTIEMKEACYAATAGVQLAQDHVRVHPDKKALVIGSDVARYGLNTPGEPTQGGGAVAMLISADPKVLALGTESSLLSEDVMDFWRPLYHTEALVDGKYSSNIYIDYFQDVFKNYLQTTQTSPDTLTALVFHLPYTKMGLKALRSVLPLVDAEKQAQWLTHFEHARQLNRQVGNLYTGSLYLSLLSQLLTDPQLQPGNRLGLFSYGSGAEGEFYTGVIQPDYQAGLDHGLPQRLARRRRVSVAEYEALFSHQLQWRADDQSVSYADDPHRFVLTGQKDEQRQYLDQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ34</accession>
    <name>F9UQ34_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640767.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79323">
        <property type="protein sequence ID" value="CCC79323"/>
        <property type="gene ID" value="lp_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2085"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1764"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419874_0_0_9"/>
    <dbReference type="OMA" id="SASWIKE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1784-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="21935" checksum="4C251F2EF92F30E4" modified="2011-10-19" version="1">MPKNTLAQFAKLMADPKVAAILKATKSKTGLTTKQISAQTKIPNNQLYYTINKMQDADLLTIVNQVQVKNLTENFYSSAHLSHETPQELADLDGLDTDLTDISGTWTQAHVQQVLQWIMLLNHDFTEAYQEEMTRKQPDKSAIFFSNAILNLSAAGEHQLRLDLIKLLGDAEKNDPDPQSTDKRQVKLLIEKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ38</accession>
    <name>F9UQ38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640771.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889841.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2089"/>
    <dbReference type="EnsemblBacteria" id="CCC79327">
        <property type="protein sequence ID" value="CCC79327"/>
        <property type="gene ID" value="lp_2089"/>
    </dbReference>
    <dbReference type="GeneID" id="57025634"/>
    <dbReference type="KEGG" id="lpl:lp_2089"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1768"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_9"/>
    <dbReference type="OMA" id="LRMENPQ"/>
    <dbReference type="PhylomeDB" id="F9UQ38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1788-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="28240" checksum="EAB0931DFA4E9AF9" modified="2011-10-19" version="1">MTNLVGKTVLVTGASSGLGEQLALAVASQGANVVLAARRRERLTQVADQCRLLSKGQAVAITCDVGHVADVDHVFTTIDELFGQLDVVINAAGFGDMTTVITMDAPVMAKMLRVNTLGTMYVSQLAAQRMVKQHAGEIVNIASMAGKIATPKSAVYAASKAAIIAYDNALRLELKDAHVNVLTVNPGPIKTDFFKIADPTGHYLDRVDQLALNPVKFAELIVSKLGHQRRELNRPWVMSAANLGYQLAPKLGDWLTGTVFNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ93</accession>
    <name>F9UQ93_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pdhA</name>
        <name evidence="10" type="ordered locus">lp_2154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889896.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2154"/>
    <dbReference type="EnsemblBacteria" id="CCC79382">
        <property type="protein sequence ID" value="CCC79382"/>
        <property type="gene ID" value="lp_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2154"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1823"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_9"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="PhylomeDB" id="F9UQ93"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1843-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="9">
        <location>
            <begin position="52"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="370" mass="41469" checksum="5919C79F8EBF9D82" modified="2011-10-19" version="1">MDNEKPIVDFGAIRDVLGKDFEPVQVLDGQAKVIKPEIVSKYSNEQLVEFFKLMLWERTLHQRSNALTRQGRLGFYAPTEGQEASEMGSNAAMKKTDVLMPAYRDIPQLIQHGLPVYKAFLWSRGHVLGNEYPEDFHAMPPQIIIGAQYVQAAGVALGIKKNGTEDKVAYTYTGDGGTSQGDFYEGMNFAGAFEAPAVFIVQNNGYAISVPRRKQTAAKTLAQKAVAAGIPSVQVDGMDFLAVYEVTKAAREYAAAGNGPVMIETLTYRFGPHTNAGDDPKRYRTKDEEQPWFDNDPLIRYRKYLTDQGVWSEDQENEYVEQVKEDIKAAVKQADEAPKQKMTEFLGNVFEEQPQNIQQQITEFQAKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM0</accession>
    <name>F9UQM0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine/histidine ABC transporter,ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnQ4</name>
        <name evidence="5" type="ordered locus">lp_2313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641493.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890023.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2313"/>
    <dbReference type="EnsemblBacteria" id="CCC79509">
        <property type="protein sequence ID" value="CCC79509"/>
        <property type="gene ID" value="lp_2313"/>
    </dbReference>
    <dbReference type="GeneID" id="57025845"/>
    <dbReference type="GeneID" id="66450057"/>
    <dbReference type="KEGG" id="lpl:lp_2313"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1954"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="ATMLKPN"/>
    <dbReference type="PhylomeDB" id="F9UQM0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1993-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23416" checksum="28C872BF646DF26D" modified="2011-10-19" version="1">MLELKNITKSFGSRTIIKNLNLTVKDGEILSIVGPSGAGKTTLLRCITGLEKVNAGEFLVDGQPFDPYTNRSNDSVIGVVFQNFELFPNLTVMQNITLAPTTVLKQSSAEAEQQAQTLLDRLNLGDHADQYPFELSGGQKQRVAIARALAMKPNVLCYDEPTSALDPNLRQEVEKLILGLKADGMTQIVVTHDLTFAENIADEMFHVEPTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP7</accession>
    <name>F9UQP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ3</name>
        <name evidence="3" type="ordered locus">lp_2344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2344"/>
    <dbReference type="EnsemblBacteria" id="CCC79536">
        <property type="protein sequence ID" value="CCC79536"/>
        <property type="gene ID" value="lp_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2344"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1981"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_15_3_9"/>
    <dbReference type="OMA" id="RSNHESW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2020-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="271"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="519" mass="58861" checksum="228E1313AF039E6F" modified="2011-10-19" version="1">MLSRGWHLVMQGARQLAGPLACWWLAGILLAVLAKVLGILVGGVVSLLGLLLLSAWLPAMVARSNHESWQAGQFLYRWVLLMFTAVWWLPLGWLGYLATLQASIQLPATVQNIIFNTRYDWLPVAGPLWLLGWLISWKWLPALQRQLTAPTSWRNYWRTGWRISWWTVFKKSRNVWLFLISWLVMAIIGGGIVWASGAVSQLVSQFVAVFMMTGLQLLAWLMFMGWWSRLWPETAIAGHSNWQTGLLTLTGLLVLGGYAGWWLGTPPTAPLAIIAHRGVNGRDGVQNTTVALKRTVKQVQPDMVEMDIQPTADRHWVVMHDPTLKALAGQPGPVHEYPVDKLSGLPLREHGQKGYLSTFKQYFAVAHKLQQPLLVEIKSVGTADQLMGIFADNYAQRLIQQKGAVHSLDYRVIERLHQRAAQLPVGFITPFYLTDFSNSVAEFYSLQALTATREQISAAHRQHRIVYFWTVDRPLAMQRLTAMGADGLITNRPGQLRRLQGQSKHYYFYQLINWLVSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY7</accession>
    <name>F9UQY7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 9, phage transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101778.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890140.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2448"/>
    <dbReference type="EnsemblBacteria" id="CCC79626">
        <property type="protein sequence ID" value="CCC79626"/>
        <property type="gene ID" value="lp_2448"/>
    </dbReference>
    <dbReference type="GeneID" id="66450187"/>
    <dbReference type="KEGG" id="lpl:lp_2448"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2068"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_066192_4_0_9"/>
    <dbReference type="OMA" id="EHTKEMI"/>
    <dbReference type="PhylomeDB" id="F9UQY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2113-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13673" checksum="D0F9805EE20B9A4B" modified="2011-10-19" version="1">MTIGKRIANLRKQKSLTQPMLADAMNVSQSTIASWESDRRSVSNDDLIKLSDYFGVTTDYLLGKNGTPKWANEKDTKDLQDFLDANEGSMTYGGEDLTEEEKQQVRVAMATIFWKRHKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ0</accession>
    <name>F9UQZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 6 endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101781.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2451"/>
    <dbReference type="EnsemblBacteria" id="CCC79629">
        <property type="protein sequence ID" value="CCC79629"/>
        <property type="gene ID" value="lp_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2451"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2069"/>
    <dbReference type="eggNOG" id="COG4748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045501_0_0_9"/>
    <dbReference type="OMA" id="PIARLHF"/>
    <dbReference type="PhylomeDB" id="F9UQZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2116-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017035">
        <property type="entry name" value="UCP035009_HsdR_All3000-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035009">
        <property type="entry name" value="UCP035009_HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="40671" checksum="BDB260A23E7894C0" modified="2011-10-19" version="1">MEKSEFENKINGLSKKVDSMSEMLKTEEATKNALVMPFFAALNYNVFDPTEFVPEYTADFGSKKGERVDYAVVINGEVQILVETKELSDDLNKRDSQLFRYFTATKAKFGILTNGDTYKFYTDLEEPNVMDKTPFLTIKLSDIKDTQITELFKFTKDNFDIDNITDSASDLKYVGLTKEYLKKQMNNPADDFVRLILAEIYDGMKTQQVVDQFRPVISKGFTQIISEQVNSKLSNALNQTVKDATASTESLKDTPDPKAEIVTTPDELESFAVTKVILRETIGQDRIVYRDNRSYFNVLIDDSNRKWVLRIYFHTNRNFIILHDDDNTELDFESPVDIMNYSDQIKKVAEQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR29</accession>
    <name>F9UR29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE4</name>
        <name evidence="2" type="ordered locus">lp_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890182.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2498"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79668">
        <property type="protein sequence ID" value="CCC79668"/>
        <property type="gene ID" value="lp_2498"/>
    </dbReference>
    <dbReference type="GeneID" id="57025931"/>
    <dbReference type="KEGG" id="lpl:lp_2498"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2104"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_21_0_9"/>
    <dbReference type="OMA" id="WNNFYEY"/>
    <dbReference type="PhylomeDB" id="F9UR29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2160-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="327"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="525" mass="59836" checksum="F7AA45D463644A58" modified="2011-10-19" version="1">MYFFITSKIDSTPSAIELAMIQRQKLFTKHRVPALIVTRNFVRDLHHNMQLIGYDDEFQVNMYDYFQGTTNYEGEPLTAANYPRVTGETLERVSANEFDVIQREQRQKALMLNAQGNIDYVDILNPQGAVSRRDYYDTRGFLTVAQYFDDKQNIVLEQHCNLQQQPVLETFFRPNEKQQPVATHQRLLNYHGHNYEFEDWDQLTAFFLDALNTEYGGHGTMIVDRSDAGMNPIVKMSTAARKYEFLHSNFTLDPLDVVNSPIVPYTQIGLDHASQMAGLIMSTQEECDDMTNHIHNVIPTLAIPVGSVSDEQLAARPVDFKDRIEGKVIAVARLSAEKNLEQLIKAVAYVHEKQSNVTLDIYGYGDSWTGFKEENRLRALVSSQRWQSFITFKGFERDLTPVYNQAQLMVLTSQYEGFNLGILEGLSHGVPVVAYDIKYGPATMITDGENGRLITPNNLVELGKVILTLLQHPKQLAKMSERAYGNSSRFSEAMIWQRWNDHVIQPDIQAMRGVTTNGNAYHVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR58</accession>
    <name>F9UR58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine sulfhydrylase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oahS</name>
        <name evidence="5" type="ordered locus">lp_2536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101818.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2536"/>
    <dbReference type="EnsemblBacteria" id="CCC79697">
        <property type="protein sequence ID" value="CCC79697"/>
        <property type="gene ID" value="lp_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2536"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2133"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_9"/>
    <dbReference type="OMA" id="TTHSQMN"/>
    <dbReference type="PhylomeDB" id="F9UR58"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2190-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="428" mass="45797" checksum="4BA464EA535059B3" modified="2011-10-19" version="1">MTTTNPENYHFETLQVHAGQTVDETGARAVPIYQTTSYVFKDAKQAAGRFALTDAGNIYTRLTNPTTDVVDKRVAALEHGTAGVTIATGSAAITAAILNIAQQGDEIVAANTLYGGTYDLFSVTLKKLGITTHFVDPDEPANFETAINDHTKALYVESIGNPGINLVDFEAIGKIAHDHGIIFIVDNTFGTPYLVRPLEHGADVVVHSATKFIGGHGTTMGGVIVEGGQFDWRASGKYPDFTTPDPQYNGLVFADLGGAAFTTKVRAETLRDTGATISPFNSFLLLQGLESLSLRVERHVTNTRKIVAFLKAHPKVAWINYPELEDSPYHDLATKYFPNGVGSIFTLGLTGGEAAGKALIEHLQLFSLLANVADAKSLIIHPASTTHAQLNEQELLAAGVTPDLIRISVGVENADDLIADLDQALAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR91</accession>
    <name>F9UR91_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101834.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890244.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2579"/>
    <dbReference type="EnsemblBacteria" id="CCC79730">
        <property type="protein sequence ID" value="CCC79730"/>
        <property type="gene ID" value="lp_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2579"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2167"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_6_2_9"/>
    <dbReference type="PhylomeDB" id="F9UR91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2222-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="145" mass="16243" checksum="84C94DA19E711FF4" modified="2011-10-19" version="1">MQIKMSNQVDSSVYADAIAIRRAVFVQEQHIDETLEIDTVTPATWHYVLYDDQKQAVATARVTPSDQWTGHVQRVATLKAARGQGYARQLLQRIAADGLSRGWRQLVLGAQVTAQGFYTQLGYQPQGRPFMEAGLRHQTMILALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA4</accession>
    <name>F9URA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formate acetyltransferase activating enzyme</fullName>
            <ecNumber evidence="10">1.97.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pflE</name>
        <name evidence="10" type="ordered locus">lp_2596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101843.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890257.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2596"/>
    <dbReference type="DNASU" id="1062824"/>
    <dbReference type="EnsemblBacteria" id="CCC79743">
        <property type="protein sequence ID" value="CCC79743"/>
        <property type="gene ID" value="lp_2596"/>
    </dbReference>
    <dbReference type="GeneID" id="57026004"/>
    <dbReference type="KEGG" id="lpl:lp_2596"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2179"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_0_0_9"/>
    <dbReference type="OMA" id="PWKYIEP"/>
    <dbReference type="PhylomeDB" id="F9URA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2234-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
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        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
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            <end position="258"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79743.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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    <name>F9URC0_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Bacteriocin immunity protein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">lp_2616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC79759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890273.1">
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    </dbReference>
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        <property type="protein sequence ID" value="CCC79759"/>
        <property type="gene ID" value="lp_2616"/>
    </dbReference>
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    <dbReference type="GeneID" id="66450302"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2396006_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2250-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0079">Bacteriocin immunity</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="93" mass="10217" checksum="720C338C8EC711F6" modified="2011-10-19" version="1">MLKNENAIALIRAIDVAYSDPEVRAIPELQQALAKAAQDLDCVADHHQVASRLNQLLTTWGARHSQGPAVLDQLYLITLKDGVDVPCQVPYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD9</accession>
    <name>F9URD9_LACPL</name>
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        <submittedName>
            <fullName evidence="7">Cell wall hydrolase/muramidase</fullName>
            <ecNumber evidence="7">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acm2</name>
        <name evidence="7" type="ordered locus">lp_2645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 73 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2645"/>
    <dbReference type="CAZy" id="GH73">
        <property type="family name" value="Glycoside Hydrolase Family 73"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79778">
        <property type="protein sequence ID" value="CCC79778"/>
        <property type="gene ID" value="lp_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2645"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2216"/>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021790_0_0_9"/>
    <dbReference type="OMA" id="GETVYYN"/>
    <dbReference type="PhylomeDB" id="F9URD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2269-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08460">
        <property type="entry name" value="SH3_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389064" evidence="4">
        <location>
            <begin position="28"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="5">
        <location>
            <begin position="237"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="416"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="493"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="569"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="646"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="722"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="785" mass="82190" checksum="E8BCD5B64328E10C" modified="2011-10-19" version="1">MKIGMTKKVVTSLLLSTALLPMLSGKADTASANQKPAAATKGNSAASAASQQVTLSAGSQTETTAAGATDQSVASDGAKTDDQAESTSTTTATTSATSRVTVRAASQAAKADSTGPQSQSSASEAAKDNAATSATADSTTSAVDQLDKTAKASAATSQASHSTTNETAKASAAASQDSHVTTDQSSVTVTSEVAKSAASSAAPKQATEQAVAAKISPKIETAVAADAVQSSAMMARSTRAMTSQEIFLSQIKAGAISGWNKYQVLPSVTAAQAILESGWGQSQLATQGNNLFGIKGSYQGQSIYFPTQEWNGSQYITIQDAFRKYPNWSASVEDHGAFLVVNPRYSNLIGVTDYRRVASLLQQDGYATAPTYASSLISIIEYNKLHEWDQEALSGQASGGNDNNQVQPDQDVTPTSGTHKFTKTTTIHNAPDATSAVVGTYNAGETVNYNGKLTVGNATWLRYQSYSGVSRYVMISQTTTNDNNNQATVTPASGSYKFTAKTNIRSAASKTAQVVGTYNAGETVYYNGKITTGGTTWLRYLSYSGAQHYVAMSGDEVGSVAKPDVVATSGSYRFTKTTAIKSSPATSATTVGSYNAGDTVYYNGKVTTNGQTWLRYMSYSGAQHYVQISGESTSTNVDKPQVTPQSGSYRFTQTTAIKNTPAGNAPSVGTYSAGDTVYYNAKVTANGQTWLRYLSYSGAQHYVAISGNAATGNTTSKPVTNSQGAFRFVTTTNIRTAPSTRASVVGEYNPGETVYYNGTVQAEGYTWLRYLSRSGATHYVAKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF0</accession>
    <name>F9URF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl xylosidase (Promiscuous)</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
            <ecNumber evidence="2">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xynC</name>
        <name evidence="2" type="ordered locus">lp_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EC" id="3.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101871.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890303.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2660"/>
    <dbReference type="ESTHER" id="lacpl-EST1">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="DNASU" id="1062899"/>
    <dbReference type="EnsemblBacteria" id="CCC79789">
        <property type="protein sequence ID" value="CCC79789"/>
        <property type="gene ID" value="lp_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2660"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2228"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_0_9"/>
    <dbReference type="OMA" id="SFFPNMT"/>
    <dbReference type="PhylomeDB" id="F9URF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2280-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="282" mass="31062" checksum="E4A9323EE2CB5DDC" modified="2011-10-19" version="1">MALIRINFMAASLHRTVPLMVCLPTDKLVPDEQGVPRPIQGPFATLYLLHGILGSEVDWISGTRIQRWADERNLAVVMPAGENSFYTDHPWSGETYSQFIGQELIDFTRRTFPLSHQRDQTFIGGLSMGGYGALYNGLKFHDIFGAIVSLSAGLNVRPGMEKLPAKPQWFAETAAYQHGVFGPDLAAAGHSELNPQVLVTKLLAAHVALPAIFMAIGDQDGLKPANDEFDHFLTAKKVSHEYVVGSGAHEWDFWDRYLLKALNWLPLTNQGAGVNSGHIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH0</accession>
    <name>F9URH0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="synonym">dapA2</name>
        <name evidence="11" type="ordered locus">lp_2685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642619.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2685"/>
    <dbReference type="EnsemblBacteria" id="CCC79809">
        <property type="protein sequence ID" value="CCC79809"/>
        <property type="gene ID" value="lp_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2685"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2248"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_9"/>
    <dbReference type="OMA" id="FHFAMNE"/>
    <dbReference type="PhylomeDB" id="F9URH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2300-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="31029" checksum="1711022AE7733B07" modified="2011-10-19" version="1">MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKRDLYTQTARIVAGRVPIIANTGTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMMAHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPNIIGIKQCGSDEELAAIVEKAPKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLMPKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ2</accession>
    <name>F9URJ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642598.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890345.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2715"/>
    <dbReference type="EnsemblBacteria" id="CCC79831">
        <property type="protein sequence ID" value="CCC79831"/>
        <property type="gene ID" value="lp_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2715"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2271"/>
    <dbReference type="eggNOG" id="ENOG5032ZEG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101317_0_0_9"/>
    <dbReference type="OMA" id="AYFESGH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2322-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="20368" checksum="67C89E86C7B4E92A" modified="2011-10-19" version="1">MPKPTTDDVNRQQLYSDAYFDTGHWGLKIRQTIVGIVGWIAVIVPITVTVLSIWSSYNPHIPRFWHYHEGLFEFKFIGILLAFCFALASLFAVTMTIIQNRKRERVVEQWPTFNPINQKKRQQLLAQFMADRFGNAEFREHTRHYRVKPEQNLDTNQIQQLYQQNNLDDIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ6</accession>
    <name>F9URQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Drug/metabolite transport protein, DMT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890409.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79895">
        <property type="protein sequence ID" value="CCC79895"/>
        <property type="gene ID" value="lp_2789"/>
    </dbReference>
    <dbReference type="GeneID" id="57026156"/>
    <dbReference type="KEGG" id="lpl:lp_2789"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2335"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_9"/>
    <dbReference type="OMA" id="GVQAFYF"/>
    <dbReference type="PhylomeDB" id="F9URQ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2386-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="159"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="308" mass="33705" checksum="BBC1D94CAC5E775E" modified="2011-10-19" version="1">MQVSREFKGIFLASISATFWGISGAVAQTLFDTTDINSIWLTGIRMLGAGIALLLVSLLTHVDLWSIWRQPRDLLQIVAYTLLGLMPVQFTYFLAVEASNAATGTILQFMGPVFIALWMLVAHRQLPTRAEGLAIICALLGSFLLVTHGNPQTLVISVWALIWGLLSGVSSATNTLLPTKLLTKYDPMTVNTWSMLLGGILFNIVQPVWSIHIPLTMLNISKLTFVVLFGTLLAFLFFLQSLQYIRPTVVSLLDAFEPLSATIIAVVLLGVSFGWLDILGSVLIISTVFILAIGQGPNDRTAENFKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR1</accession>
    <name>F9URR1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101918.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2795"/>
    <dbReference type="EnsemblBacteria" id="CCC79900">
        <property type="protein sequence ID" value="CCC79900"/>
        <property type="gene ID" value="lp_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2795"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2340"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012726_0_0_9"/>
    <dbReference type="OMA" id="MDIEAND"/>
    <dbReference type="PhylomeDB" id="F9URR1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2391-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07523">
        <property type="entry name" value="Big_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394307" evidence="3">
        <location>
            <begin position="37"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="4">
        <location>
            <begin position="546"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="4">
        <location>
            <begin position="627"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="4">
        <location>
            <begin position="717"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="4">
        <location>
            <begin position="792"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
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        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113076" checksum="A29CFD69C937C94C" modified="2011-10-19" version="1">MEQVKKRYKMYKSGKMWLFAGITLVTLNMNVVTGRADESTHVEALTEPAVATLSEGNAEQQSPVTDAMDESAMSELVTEAQPIKVQAAEEQYTDEIVNQSDDEHANSDQVSVPVTDQVDSETPVPSDEHTATLDTHPNQSTTDDSEQPVSADEQSQDIDTDSTAKVLSSQHKTETINERGSGDLAGVIRNPERPHLTDGYRNDDMEDDDSMAGIWGAGYNADGIKWHFDADSGVLVLDGGDIYDCYGDSPWQSKSWVLQIVKVVISKPIRIIGDSGGFFENLTNVEHYEGLEKIDVSSATDLRYFFSENTHVKELDLSSWQVGNVTDMSYLFFNSPGTSQLTTINISGWDTRRVSEADYMFGPNEKLTRIIGIENLNFESLKEAGGLFIKTGLSELDLSKWKTDSLDNMAAWFMDMHNLTSVKFGSQFKTDQVTWIHLLFSGCSNLTEVDLSGFNLHRVEQNLDMFAGCERLQKITLGPDTDLTPAKIESVGLMDIEANDQYTGYWINVANPQQRLTSAELMNLYSEKNTPIGTYIWEANQAVIDANDITLEVGDDWNWTDSIESLTDQFGQKVDVQALYVANPQAVKLSGDRVNTSQPGTYQVTFKYAGKTVTALVIVKADQTSLTVHDTELHAGGTWHAQDGFDGATDKDGHAIDFNDVTITGEVNTMVPGDYQITYTYGSQTQTITVTVKENQASLNLYQNHATVHTDGQGTSTWQPQSNFQNATDSDGQTLDWSAIEVVGTPDWTTAGDYRLTYQFTDKTGQLVTATMTVTVVIEEADEQAESQSDLQIHDSTITVGESWQPSDNLVLATDVNGGELSLADLVVTGTVDTNQAGVYQVTYQYTDASGQVFTRVATVTVVAASDGDTNTEQPGATNTNDDVNGGSTGSIDGDDQAEIPTDDADQMEGDAADVDANAVIDDATPAVGTNHGKGADRNSGMQTTANGAKSVVTSWTHRSQMTNTASLQHAQTIVGGHHQESRPTESASVAVQPVTAKLGTSALPQTGEAPSRANVMGTVLLGLTMFGSWLGFRRVKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS0</accession>
    <name>F9URS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1393 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2806"/>
    <dbReference type="EnsemblBacteria" id="CCC79909">
        <property type="protein sequence ID" value="CCC79909"/>
        <property type="gene ID" value="lp_2806"/>
    </dbReference>
    <dbReference type="GeneID" id="57026174"/>
    <dbReference type="KEGG" id="lpl:lp_2806"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2349"/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="F9URS0"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="18081" checksum="2CE138C1CE87F866" modified="2011-10-19" version="1">MKVLVGVKFNTRTIAILGMLIALNVVISIFFHIPIPMTHGYINLCDAGIFIAALIFGWRGGVIVGGASGLLLDLLLGYPQYMFFSLLVHGLEGGIAGYLGASKSHGRQIAAIITAVVVMVVGYFLSDSLLYTMATGLVGVPTNLVQAVVGGILAFPIVAGIRPIVKRHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT8</accession>
    <name>F9URT8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ansB</name>
        <name evidence="4" type="ordered locus">lp_2830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2830"/>
    <dbReference type="EnsemblBacteria" id="CCC79927">
        <property type="protein sequence ID" value="CCC79927"/>
        <property type="gene ID" value="lp_2830"/>
    </dbReference>
    <dbReference type="GeneID" id="57026192"/>
    <dbReference type="GeneID" id="66450467"/>
    <dbReference type="KEGG" id="lpl:lp_2830"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2368"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_9"/>
    <dbReference type="OMA" id="EICENYV"/>
    <dbReference type="PhylomeDB" id="F9URT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2424-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="3">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="50445" checksum="8D653B89DBFE39F6" modified="2011-10-19" version="1">MRIEADCIGKLAVPDDALYGIHTLRAVHNFPITTELMHPLIMQSLVQIKKAAASVNAAAGTLSNDKAHAIIAACNQLLLGRYADNFIVPAIQGGAGTSANMNVNEVVANLAHRLMPAVAVHPNDDVNQSQSTNDTFPTAGKMALCMQLPGLLTALSRLVQTLLVKSQRYQDAIKVGRTQLEDAVPTTYGRTFHAYYQLFKRDLTRVRQAGEHLRIVNLGGTAIGTGINATHTYQQQILVKLNQNTDLDLVAAPDLIDATQNCDLFVEFSAAMKTLAVDLSKFSNDLRLLASGPQAGFGELNLPAQQAGSSIMPGKINPVIPEVVNQVAFEVIGHDTTVTMAAEAGQLELNAFEPIMLRALLASEQHLQQALTTLVDHCVRQLTVNRQRCADQVAHSAITATVLAPYLGYETTTALIKEALTTNQAIPELLHRRRLLSDDLVEQLFSPAGLTQPRPEVIEQLRAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV4</accession>
    <name>F9URV4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmd</name>
        <name evidence="2" type="ordered locus">lp_2852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.44" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890457.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2852"/>
    <dbReference type="EnsemblBacteria" id="CCC79943">
        <property type="protein sequence ID" value="CCC79943"/>
        <property type="gene ID" value="lp_2852"/>
    </dbReference>
    <dbReference type="GeneID" id="57026208"/>
    <dbReference type="KEGG" id="lpl:lp_2852"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2385"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_5_0_9"/>
    <dbReference type="OMA" id="IPMHIRA"/>
    <dbReference type="PhylomeDB" id="F9URV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2440-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047575">
        <property type="term" value="F:4-carboxymuconolactone decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11727" checksum="3FF2C133F7571D74" modified="2011-10-19" version="1">MTVKQTAGRDNLGKLAPQFAALNDDVLFGEVWARESTLSLHDRSMITIACLMTSGDFPQLKAHFKMGKDHGISKDEAVEIVTHLAFYAGWPKAWSAMALIKEVYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV8</accession>
    <name>F9URV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890461.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2856"/>
    <dbReference type="EnsemblBacteria" id="CCC79947">
        <property type="protein sequence ID" value="CCC79947"/>
        <property type="gene ID" value="lp_2856"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2856"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2389"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005531_0_1_9"/>
    <dbReference type="OMA" id="VITSEQW"/>
    <dbReference type="PhylomeDB" id="F9URV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2444-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="365"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="763"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="863" mass="96934" checksum="81198366D887BA04" modified="2011-10-19" version="1">MVGAAMTAAYFKTIMREIWSSKARFASILLIIFLGVAFYTGIRATGPDMSQAANDYYAKQKLATNSVQSTMGLTKADTRVLNQHRSQLTYQATRYADVNQLNNSQVVRVMVLPTTQRLNRLRIVKGRLPRHANEIVLDAQAQRLQPKLKVGSTYRISSTAKRNAQFTRRTFKVVGFVNSPTYVENTNRGVTNVGKGTLDYLVYVRPQVIKSSVITRIDVQFKNLRGVTPYTAKYRRLNRENTAQLKRWLKPQARKRQQALQAQAQAKLKPLRQATQQLASQVPAGTAQLVKLQSQLKRAKAQVAAITMPTYLYTDRTDNPGYTEYHENTQRVVALSTVFPLFFIAIAALICLTTMTRMVEELRLQMGTLKALGYTNTAVGSEFMIYGGLAALIGTALGVLFGVNFFPRFIAQAYGSMYNLPAINVQYIWMDIGIALAIALLCTLGTALVVLRVDLNSLPAQLLQPRSPKAGKTLLLERWQWLWHRLSFNHKITLRNLFRYKQRLLMTVLGIAGCMAMMITGFGLKDSIGDISVKQFNELWHYDAVVTRSGNETDQQRQALSRGQLYQASLKLQAKQVTVKQSGVAEQTATLGIPAPHQSLSKFVVLRHRQSHQAIHIGDRGAVIDEKLAKLYGVQAGDDLTIKLAGQTTKRIHISAVAENYVNHFIYMSPTYYRRVFKQAPVYNTNYVRFKQATKKQENAYADRLLKQAGVQNVTLMSTEKATNFKMLDSMNLVVLIFVISAGALALVVLYNLTNINVSERIRELSTIKVLGFYDGEVTMYIFRENLILTVLGIIAGCFLGNWLHAYILQTAETNALMFSPTIHPLSYVYAALLTLAFSLLVMGMMHRKLKRVNMLDALKSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW4</accession>
    <name>F9URW4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sip2</name>
        <name evidence="8" type="ordered locus">lp_2863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101940.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890467.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2863"/>
    <dbReference type="EnsemblBacteria" id="CCC79953">
        <property type="protein sequence ID" value="CCC79953"/>
        <property type="gene ID" value="lp_2863"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2863"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2396"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_0_9"/>
    <dbReference type="OMA" id="LLKYPRW"/>
    <dbReference type="PhylomeDB" id="F9URW4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2450-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23404" checksum="E36F3F6BC14539A2" modified="2011-10-19" version="1">MTTKVKVVLSWLLPIIIGLIIALLIRQFWFTVVKVDGNSMQPNLQNNQHVVAVKTSTIKRGSVIVFHAYGVDATQADHNAVYVKRVVAVGGDKVRYTHAGKLYVNNKLVKQTYQPNHYQLTTGSYMANAHSQFTGWTLTSLSHNQPAWQVTVTNNRVPKGSYFVLGGHRSVSNDSRNWGFVSQNKVIGVVKAWPWQNRQQYINHFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW8</accession>
    <name>F9URW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890471.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2867"/>
    <dbReference type="EnsemblBacteria" id="CCC79957">
        <property type="protein sequence ID" value="CCC79957"/>
        <property type="gene ID" value="lp_2867"/>
    </dbReference>
    <dbReference type="GeneID" id="57026220"/>
    <dbReference type="GeneID" id="66450497"/>
    <dbReference type="KEGG" id="lpl:lp_2867"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2400"/>
    <dbReference type="eggNOG" id="ENOG5030A3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2287934_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2454-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="101" mass="11209" checksum="905C74DDE1AFEC02" modified="2011-10-19" version="1">MQVNVITSTVAGQETVATADVQAFMAAMEKQLGADFNFTLDTDYGQSLTDHSADVYLVYFGSQANLSPEQRSQMIIFYSDEDVANLTIGRFVDMLQQLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9US44</accession>
    <name>F9US44_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaC</name>
        <name evidence="14" type="ordered locus">lp_0014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0014"/>
    <dbReference type="EnsemblBacteria" id="CCC77591">
        <property type="protein sequence ID" value="CCC77591"/>
        <property type="gene ID" value="lp_0014"/>
    </dbReference>
    <dbReference type="GeneID" id="57026875"/>
    <dbReference type="KEGG" id="lpl:lp_0014"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.12"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_9"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="PhylomeDB" id="F9US44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-12-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC77591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="474" mass="51761" checksum="997607E91052CBD3" modified="2011-10-19" version="1">MNNDVLDQTPPQNIEAEKAVLGAIFLNSDALVEAMEFVEAQDFYRRAHQIIFASMVTLNDRDEAIDAVTVSDLLTAQNQLDDVGGMSYIAELAGSVPTAANAGYYAKIVAQKATVRRLIKTATEITQKAYTENDDVTTLLDDAERDIMNVSEQRNQSGFKSISDVLNASIEEIDRLYQNDDDITGLPTGFAELDKMTAGLQPDNLIILAARPAVGKTAFVLNIAQNVATKTDTTVAIFSLEMGAESLVNRMLCAEGSIDAGHLRTGQLNEEEWEHLVVAMGSLSKASIFIDDTPGIKMSEIRAKSRRLAKEQGNLGLIVVDYLQLIEGSNTESRQQEVSEISRQMKKLAKELGVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYREDYYDREGGDDDDGGNFGGGGDFNGGDPRDEDASEDVGEVEVIIEKNRAGARGTVKLLFVKPFNKFSSVSYAQDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9US69</accession>
    <name>F9US69_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">calB</name>
        <name evidence="8" type="ordered locus">lp_0047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100858.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0047"/>
    <dbReference type="EnsemblBacteria" id="CCC77616">
        <property type="protein sequence ID" value="CCC77616"/>
        <property type="gene ID" value="lp_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0047"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.38"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_6_9"/>
    <dbReference type="OMA" id="RRITWAA"/>
    <dbReference type="PhylomeDB" id="F9US69"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-38-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="476" mass="52621" checksum="B59FF9CBE5D1AE17" modified="2011-10-19" version="1">MMTTINEMHQIFNLQKIQYDRAQPMTYEERVTVLNQIEALIRDNIPELITALQADFGQRDPLQILSADLTGPLATIAYIKKHLRKWILPAKQRSGLMALTGTKQYVYNEPLGVVGIMSPFNAPIDLALDPAVEAIAAGNRVMVKISEYTPKTAALVQKLSQQYLNEKNFAVVTGEADIAAQFSALDWDKLVFTGGSETGKKVLSAAAPNLTPVVLELGGKNPAVVLPDANKQMTAAKIARSRSGNSGQICLDTDYVLLPTDQLDEYVGLITAQLAQVFPTYINNSEYSAIINDRSYDRILGMLTEARQRGTRLITINPNNELVPYVKRRLIPLTLAINPDRDLQIARNEIFGPILSIFTYDSLDEAIAFINSHEKPLAMYLFGRSSRHLNQIISQTSSGGVDINELSLHAGSHSMGFGGVGYSGMGRYKGGKIGFETFSNQKSVYKQGVLAKYTTRLMVPIHNKRNEKLLKRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB7</accession>
    <name>F9USB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid ABC transporter,substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">livA</name>
        <name evidence="3" type="ordered locus">lp_2985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2985"/>
    <dbReference type="EnsemblBacteria" id="CCC80047">
        <property type="protein sequence ID" value="CCC80047"/>
        <property type="gene ID" value="lp_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2985"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2492"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_9"/>
    <dbReference type="OMA" id="MEFTGAR"/>
    <dbReference type="PhylomeDB" id="F9USB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2542-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389087" evidence="1">
        <location>
            <begin position="28"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="40"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="41853" checksum="5BC4BE7BA5D01EFB" modified="2011-10-19" version="1">MKKWEKQTMKIAALGAMALTLAGCATAKSSSSQGNNPGKTIKIGVNMELSGSAAGYGEQQKQGIQLAVKKINKSGGIKVGGTKKKIQLVIRDNKTSNTTAASVAAQLVNNDKVVAVVGPATTSAGTAAIPNMTKAAVPSVSPSATDPDYTLQKSGKVQKYIFRACYQNNFQGATAATFVTKNLKAKRVAILTDNSSDYGTGLTKAFKKQYRGTVVSSQTFQEGDKDFNAILTALKHKKIDAIYAPGYYSEIGLIVKQARQAGIKAPIVGSDGMADAKLAQIAGKSNATNVYYTTPFSTKASATNKVASKFMSAYKAKYGSTAPTFSALAYDSVYMIKAAIEKEGSANSVKIADGLAKLKNFKGVTGTMTIDKQHNPEKTISIEQLTNGVVSKVYNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF8</accession>
    <name>F9USF8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642288.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890602.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3031"/>
    <dbReference type="EnsemblBacteria" id="CCC80088">
        <property type="protein sequence ID" value="CCC80088"/>
        <property type="gene ID" value="lp_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3031"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2534"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_2_0_9"/>
    <dbReference type="OMA" id="FTGTVWQ"/>
    <dbReference type="PhylomeDB" id="F9USF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2581-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="15151" checksum="DC0DAD1C55421FE7" modified="2011-10-19" version="1">MNNNENSVQHGIFAMGDLNVAFQQYFTGKSYHNALVKDEQVNVTVSNVSFEPGARNNWHIHHNGYQILLVTGGEGWYQEAGQPAQRLHPGDVVITHDGIKHWHGATKDSWFSHIAITAGTPEWLSPVSNDEYNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG1</accession>
    <name>F9USG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, subgroup 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642292.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890605.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3034"/>
    <dbReference type="DNASU" id="1062855"/>
    <dbReference type="EnsemblBacteria" id="CCC80091">
        <property type="protein sequence ID" value="CCC80091"/>
        <property type="gene ID" value="lp_3034"/>
    </dbReference>
    <dbReference type="GeneID" id="57026360"/>
    <dbReference type="KEGG" id="lpl:lp_3034"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2537"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="INYEITH"/>
    <dbReference type="PhylomeDB" id="F9USG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2584-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="218" mass="24031" checksum="75EFBCDB1BD21DB6" modified="2011-10-19" version="1">MTKVLILGANGRIARIVEQRLLAETDVQLTLVLRNAGRLLVTSPERETVIQGDVSDSQLLDTVMPNQDIVYANLAGNMALLAQTIITSMNRNHVPHLIWVTGSGLYHETPNPFGAWVEQVVGHAAKNDTRHAARIIESSDIPATIIRAAYMTDDTKIDYELTYKGERFKGTMISRASIADLIMKIIAEPTAYENTSLGIAQPGTDNMLPQVKLMAQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI0</accession>
    <name>F9USI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of competence TfoX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642314.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890624.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3062"/>
    <dbReference type="EnsemblBacteria" id="CCC80110">
        <property type="protein sequence ID" value="CCC80110"/>
        <property type="gene ID" value="lp_3062"/>
    </dbReference>
    <dbReference type="GeneID" id="57026379"/>
    <dbReference type="KEGG" id="lpl:lp_3062"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2557"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163277_2_1_9"/>
    <dbReference type="OMA" id="CIHRLYA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2603-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007077">
        <property type="entry name" value="TfoX_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04994">
        <property type="entry name" value="TfoX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_C" evidence="1">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="94" mass="10296" checksum="FBF0FAC4564DEFFD" modified="2011-10-19" version="1">MIMNRKDLNLVALLTTLPNIGPTLAKQLQAVAITTPEQLKSTGSKVAFTAIKKANPHACIQLLYSLQGAIENCAYPQLSPATREDLKQFFRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI9</accession>
    <name>F9USI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890633.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3072"/>
    <dbReference type="EnsemblBacteria" id="CCC80119">
        <property type="protein sequence ID" value="CCC80119"/>
        <property type="gene ID" value="lp_3072"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3072"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2566"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_1_0_9"/>
    <dbReference type="OMA" id="QQSKSAM"/>
    <dbReference type="PhylomeDB" id="F9USI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2612-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="2">
        <location>
            <begin position="163"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="347" mass="38526" checksum="819C0CF3F796DC31" modified="2011-10-19" version="1">MMLTKRWWQLGIGLLVGLVSLSWGRTGSANTVGFEVAPVASKYQIDKAVSYYDLKLKPSQTTTLAVKVTNTSTQEITVHTAIVPATTNPNGVVEYQATADGKNIDLPADASQLITTAANKITLAKGTSKIVTFKVKMPAQKYDGVVVGGLSFLKKAAKQQSKSAMAIKNQYAYSVAVVLHGDHALTKNKLTLGKIDATQNNGYNQISLPLQNRTAAFLNQVKTDVQIYRRGSNKVRYKQVNEHGQMAPNSVYALPLRVGRDALKPGQYTAKLAVKSKKQHWTFTKDFEITRDRANQLNKTAVIEHHTNWGLWISLGLLVILLLLIAWYIHRKQLKIKRLEERLKDKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST0</accession>
    <name>LARB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridinium-3,5-biscarboxylic acid mononucleotide synthase</fullName>
            <shortName evidence="7">P2CMN synthase</shortName>
            <ecNumber evidence="4">2.5.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactate racemase accessory protein LarB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lactate racemase activation protein LarB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lactate racemase maturation protein LarB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5 8">Lactate racemization operon protein LarB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nickel-pincer cofactor biosynthesis protein LarB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nicotinic acid adenine dinucleotide carboxylase/hydrolase</fullName>
            <shortName evidence="7">NaAD carboxylase/hydrolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">larB</name>
        <name evidence="8" type="ordered locus">lp_0105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6750" last="6761">
            <title>Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Goffin P."/>
                <person name="Deghorain M."/>
                <person name="Mainardi J.L."/>
                <person name="Tytgat I."/>
                <person name="Champomier-Verges M.C."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="16166538"/>
            <dbReference type="DOI" id="10.1128/JB.187.19.6750-6761.2005"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="5598" last="5603">
            <title>Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
                <person name="Hausinger R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27114550"/>
            <dbReference type="DOI" id="10.1073/pnas.1600486113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide (NaAD) and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) (PubMed:27114550). LarB can hydrolyze NaAD directly or it first forms an adduct with NaAD that releases AMP and reacts with bicarbonate/CO2 to generate P2CMN (PubMed:27114550). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:137353"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.5.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">13 uM for nicotinic acid adenine dinucleotide</KM>
            <KM evidence="4">33 mM for NaHCO(3)</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Induced by L-lactate and repressed by D-lactate. Is thus regulated by the L-lactate/D-lactate ratio. Makes part of the lar operon (larABCDE).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Deletion of this gene leads to a loss of lactate racemase activity.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.143" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100884.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888175.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="7MJ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.01 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-246"/>
    </dbReference>
    <dbReference type="PDB" id="7MJ1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-246"/>
    </dbReference>
    <dbReference type="PDB" id="7MJ2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-246"/>
    </dbReference>
    <dbReference type="PDBsum" id="7MJ0"/>
    <dbReference type="PDBsum" id="7MJ1"/>
    <dbReference type="PDBsum" id="7MJ2"/>
    <dbReference type="AlphaFoldDB" id="F9UST0"/>
    <dbReference type="SMR" id="F9UST0"/>
    <dbReference type="STRING" id="220668.lp_0105"/>
    <dbReference type="EnsemblBacteria" id="CCC77661">
        <property type="protein sequence ID" value="CCC77661"/>
        <property type="gene ID" value="lp_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0105"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.85"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_9"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="PhylomeDB" id="F9UST0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-83-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-20305"/>
    <dbReference type="BRENDA" id="2.5.1.143">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000441653" description="Pyridinium-3,5-biscarboxylic acid mononucleotide synthase">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
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        <location>
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        </location>
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    <feature type="helix" evidence="12">
        <location>
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    </feature>
    <feature type="helix" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
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        </location>
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        </location>
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    <feature type="helix" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="211"/>
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        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
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        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7MJ1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7MJ2"/>
        </source>
    </evidence>
    <sequence length="246" mass="25293" checksum="E6B7E216FCA49C73" modified="2011-10-19" version="1">MATTAEILQQVAAGQLSPTAAAQQLEAGKTAALGFANVDLDRQRRNGFPEVIYGAGKTATQIVGIVQALSQQTLPILTTRLSAEKFAALQPALPTAVYHATAQCMTVGEQPAPKTPGYIAVVTAGTSDQPVAEEAAVTAETFGNRVERVYDVGVAGIHRLFAKLDVIRGARVVIVIAGMEGALASVVGGLVDKPVIAVPTSVGYGTSFQGMTALLTMLNSCASGITVVNIDNGFGAAYSASMVNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY4</accession>
    <name>F9USY4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family,maltose-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888229.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0172"/>
    <dbReference type="DNASU" id="1061295"/>
    <dbReference type="EnsemblBacteria" id="CCC77715">
        <property type="protein sequence ID" value="CCC77715"/>
        <property type="gene ID" value="lp_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="57027002"/>
    <dbReference type="KEGG" id="lpl:lp_0172"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.140"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="OMA" id="ARWVGPP"/>
    <dbReference type="PhylomeDB" id="F9USY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-137-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI"/>
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    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="37966" checksum="B5AA3A1A2C84C7FF" modified="2011-10-19" version="1">MATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASNTIGVVLPVDHHEIFSNPFFLEMIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGHIKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTSYVDNDNIQAGTDAAQYLIDHGHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYPDVTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLGEEAAKIAMADHPADELSTAVIVPHQIVKRHSVHQIKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ6</accession>
    <name>F9USZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructokinase</fullName>
            <ecNumber evidence="1">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sacK1</name>
        <name evidence="1" type="ordered locus">lp_0184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641780.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0184"/>
    <dbReference type="EnsemblBacteria" id="CCC77727">
        <property type="protein sequence ID" value="CCC77727"/>
        <property type="gene ID" value="lp_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="57027014"/>
    <dbReference type="KEGG" id="lpl:lp_0184"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.152"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_3_0_9"/>
    <dbReference type="OMA" id="AWQNFNF"/>
    <dbReference type="PhylomeDB" id="F9USZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-149-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="30616" checksum="6B56D9B0F6891BBD" modified="2011-10-19" version="1">MLLGAIEAGGTKFVCATGAENGQVSDRISIPTTTPAETMTAVDDYFTTHPVDAIGIGSFGPIGVNPDDPKYGYITTTPKPGWGDFDFLGHLKSRFNIPLYWTTDVNEAAYGESMIGIAKDVPNSIYMTIGTGVGAGVISQNHIFNGRTHTELGHMRLNRLPGDDFKSNCPYHDICLEGLAAGPAVGKRTGKAGKDIPVDDPVWPIIADYIAQACVNLTVAFAPDKIILNGGVMNQRQLFPMIREKFAAYLNGYEEVPPLDDYIVPAGLGNNSGIAGGLLLAQAALKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ9</accession>
    <name>F9USZ9_LACPL</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ordered locus">lp_0188</name>
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    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888244.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0188"/>
    <dbReference type="EnsemblBacteria" id="CCC77730">
        <property type="protein sequence ID" value="CCC77730"/>
        <property type="gene ID" value="lp_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="57027017"/>
    <dbReference type="KEGG" id="lpl:lp_0188"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.155"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_9"/>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="PhylomeDB" id="F9USZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-152-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="326" mass="36231" checksum="5B02A0E4E428AC91" modified="2011-10-19" version="1">MKPKLNDVAKLAGVSATTVSRVINNHGYLSSQTKEKVFAAMRELHYQPNNMARSLQGKNTRLIGVIFSDISNPFFGELVSRIEKILFAKNYKVILCNSADDPQKERDYLQMLMANQVDGIIAGAHNLGIEEYQQYGLPIISFDRYLSDNIPIVSSDNYQGGWLATQTLHQAGATNVAIFTGKSHAGSPTNGRREGYEAYLTAQQLTPHVHELPFELTPALKMMEIKTIMTQHQYDGIFCSDDLTALLVLNVARQLSLTVPEQLRVVGYDGTALIRDYHSELTTVEQPLADISTLLVSLLLQRIEDANCTLESKYTLPVKLIKGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT28</accession>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641815.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888273.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0224"/>
    <dbReference type="EnsemblBacteria" id="CCC77759">
        <property type="protein sequence ID" value="CCC77759"/>
        <property type="gene ID" value="lp_0224"/>
    </dbReference>
    <dbReference type="GeneID" id="57027046"/>
    <dbReference type="KEGG" id="lpl:lp_0224"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.186"/>
    <dbReference type="eggNOG" id="ENOG5030A0D">
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    <dbReference type="HOGENOM" id="CLU_1862659_0_0_9"/>
    <dbReference type="OMA" id="TKRSWRY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-181-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="15952" checksum="EB786DEBDAE4A02D" modified="2011-10-19" version="1">MKKIRDERLILQNFKNIRTTLLIENSAILLILFWQGWQKNNLQKAFTYDNPLYIVLMIAVFTMIILSVNVSTPIEDKPKRSWRYLGLWALIELIGFTALFYFLIAINQPFISLIAGIALTTVTSGIMLYSNHLRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT32</accession>
    <name>F9UT32_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTS system mannitol-specific EIICB component</fullName>
            <ecNumber evidence="4">2.7.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">EIICB-Mtl</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">pts2CB</name>
        <name evidence="19" type="ordered locus">lp_0230</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:33363"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.197"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.197" evidence="4"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0230"/>
    <dbReference type="EnsemblBacteria" id="CCC77763">
        <property type="protein sequence ID" value="CCC77763"/>
        <property type="gene ID" value="lp_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0230"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.191"/>
    <dbReference type="eggNOG" id="COG2213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="GWAIKRF"/>
    <dbReference type="PhylomeDB" id="F9UT32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-185-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022872">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05567">
        <property type="entry name" value="PTS_IIB_mannitol"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029503">
        <property type="entry name" value="PTS_EIIB_mannitol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
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    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004718">
        <property type="entry name" value="PTS_IIC_mtl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00851">
        <property type="entry name" value="mtlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="18">
        <location>
            <begin position="29"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="17">
        <location>
            <begin position="400"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCC77763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="612" mass="63846" checksum="FFA00D04D1682E9C" modified="2011-10-19" version="1">MSENVNTNATQSAPVAKKKLGVKARVQKFGSALSNMVMPNIGAFIAWGLITAIFMAGGWWPNAGLAKMIQPMVHYLLPLLIAFTGGTLFAGHRGGVVGAIATMGVIVGSSIPMFIGAMIMGPLGGWCIKKWDDAISDKIKSGFEMLVNNFSAGIIGMLLAILGYFAIGPLVAGASAAMAAGVDWIIKMKLLPLANVFIEPAKILFLNNAINQGILTPLGIQAASSAGKSILFLLEPDPGPGLGVLLAFALFGKGTAKASAPSAIIIHFLGGIHEIYFPYVLMKPALFLAVIAGGVTGTATFSLLNVGLRSTPSPGSIISLLLMSPKSISNYIGLIIGVTLATLASFIVAAIVLKRDKSTGDDDLAAAQGKMSDMKSGNAEAASATDAEPADVIASYKDVDHIIFACDAGMGSSAMGASLLRDKVKKAGISMSVTNTAISNLKDEPGLLVITQNELADRAAQKAPHALRLAVDNFLSSPKYDQVVVNLKARDQVSDAAPASAAPQATTTAPDDLPANLDLSVVDEIVFVHHDGHLGTATMATSLMKDRVKKANKHVSVKNLGIDELADNNSLLVVSSAEAAKNLKTRYTQVQVLITDDLLSSPKYDKMVSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC2</accession>
    <name>F9UTC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890754.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3218"/>
    <dbReference type="EnsemblBacteria" id="CCC80240">
        <property type="protein sequence ID" value="CCC80240"/>
        <property type="gene ID" value="lp_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3218"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2688"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077122_0_0_9"/>
    <dbReference type="OMA" id="KTRRYHV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2728-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="311" mass="33463" checksum="07846BB251EA5C37" modified="2011-10-19" version="1">MRKTIRVGIILLVVGLLLIMFGIANNGIQSVYWDQGFHIVRHKTRRYHVSQLKDITIATANNITIKQGTAANITVTATRALPTVTTNNGHVTVTSTTHNAKTVGFMFDNVGQFADTTIITVPKGTTIHQITAKASQSGNVSLQKVTVDQLKSLSTDSDINLTDVKVNQSLTLTGDNLRLTRVSAPSLQINSDPDISITDSHFTKTASKIITADSDIHLTNNQFKALKLTSSEGDIMLNNNRITESLSATASDGDIRITAPRTTGVKASTSDGDLHIFNHLQSDGGDYQVNQSAAVQYRLTTSNGDITVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF3</accession>
    <name>F9UTF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890785.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3256"/>
    <dbReference type="EnsemblBacteria" id="CCC80271">
        <property type="protein sequence ID" value="CCC80271"/>
        <property type="gene ID" value="lp_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3256"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2719"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_2_9"/>
    <dbReference type="OMA" id="IHMTSGL"/>
    <dbReference type="PhylomeDB" id="F9UTF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2759-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="279" mass="29645" checksum="6582F7FA15ECEEAF" modified="2011-10-19" version="1">MTIKIVTDSSVQLTTAEIAQYNIKVVPLLVGFGGDLIADTAVSTAEFDQQMAVSPVLPTTSQPPIGDFVSCYDELTADGSQVLSLHLTETLSGTVNAARQAAKLASGDVTVIDTQAADRGMAFQVLTAARMAHAGADMATILAKITVIRQHTKTYLFVDTLDNLVKGGRVPKLAGMVTNLIKLKFVFELEAGKLKLYTRGRGKKALIKAQEQILDQLADATRVEAAGISYVGEPSVAEAPEKLLQQVVPQVTPLVARTSPIIATHTGVGAYALMFYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF9</accession>
    <name>F9UTF9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glyK</name>
        <name evidence="5" type="ordered locus">lp_3266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3266"/>
    <dbReference type="EnsemblBacteria" id="CCC80277">
        <property type="protein sequence ID" value="CCC80277"/>
        <property type="gene ID" value="lp_3266"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3266"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2726"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_9"/>
    <dbReference type="OMA" id="SIEMNEC"/>
    <dbReference type="PhylomeDB" id="F9UTF9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2765-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="370" mass="38379" checksum="6E1AAB083DF0524F" modified="2011-10-19" version="1">MHALIAIDSFKNSITSIQANRIVAKRFAAHGITATQVAIADGGEGTVAAWLANHAGGQAITASTVDLAQRPVTATYGYFATEKMAVIEVAAASGIQFVTTTLTPLATNTYGTGLLIKDAIERGARQIILGLGGSGTVDGGAGILRALGYRFWAADGQELAMTGADLSRVTKIDDRHVLPQLAEVSFISAADVTNPLTGPNGAAKIFGPQKGLPVAQIQVHDAALAHYMTVAAGAVSAHEGDGAAGGIGFALRYFLHARVCSGFQLLAEMSNLKTKVAQADLVISGEGQVDDQSFMGKVPIQLSQLAQAAGKPCYLLVGRQKGANETFAKQGVTAVLPIVDQVMTLDQAMAQGPANLERMADRLARIISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG7</accession>
    <name>F9UTG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890799.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80285">
        <property type="protein sequence ID" value="CCC80285"/>
        <property type="gene ID" value="lp_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3275"/>
    <dbReference type="eggNOG" id="ENOG5030B9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139714_0_0_9"/>
    <dbReference type="OMA" id="YEYTFAT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2773-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="160" mass="18445" checksum="663D1B5CCF7B5A3E" modified="2011-10-19" version="1">MSSFLKAKTVTHYVLFAIILISSFCLYGYVKNRIELNQARTVLTTMLKSSPYDVRVSRNTIIKEESGPFSGIIWYEYTFATSQTLAESKKYKKFLHQSSKNMTLKNCPIVYRVIVRPPTKRIKHWTGEIYLDTNQKLSATGRSNYVQALSDKSLRELTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH9</accession>
    <name>F9UTH9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890811.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80297">
        <property type="protein sequence ID" value="CCC80297"/>
        <property type="gene ID" value="lp_3291"/>
    </dbReference>
    <dbReference type="GeneID" id="57026560"/>
    <dbReference type="GeneID" id="66450825"/>
    <dbReference type="KEGG" id="lpl:lp_3291"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2747"/>
    <dbReference type="HOGENOM" id="CLU_2633662_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2785-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="77" mass="8961" checksum="422A990488884EA2" modified="2011-10-19" version="1">MINFVFYKYYRFWAAIVLLLLSANVYPAIVNGNVLGREFWRNGTNLINLVFVIVAIGFLIQVLFFKKGEPRANERAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ1</accession>
    <name>F9UTJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645462.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890823.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80309">
        <property type="protein sequence ID" value="CCC80309"/>
        <property type="gene ID" value="lp_3305"/>
    </dbReference>
    <dbReference type="GeneID" id="57026571"/>
    <dbReference type="KEGG" id="lpl:lp_3305"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2760"/>
    <dbReference type="eggNOG" id="ENOG5030APG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162586_2_1_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2797-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="86" mass="9598" checksum="85DDDCB8876FD86F" modified="2011-10-19" version="1">MAQISVGDRVKCQKNGNTDYDFYAKVEKIYENSAFVTITHYDLRDDINVAELQYRAVIALKKMKPAKPTAGEAKQLQAVSAAMLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR7</accession>
    <name>F9UTR7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
            <ecNumber evidence="3">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndh1</name>
        <name evidence="3" type="ordered locus">lp_0313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888351.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0313"/>
    <dbReference type="EnsemblBacteria" id="CCC77837">
        <property type="protein sequence ID" value="CCC77837"/>
        <property type="gene ID" value="lp_0313"/>
    </dbReference>
    <dbReference type="GeneID" id="57027124"/>
    <dbReference type="KEGG" id="lpl:lp_0313"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.266"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_2_9"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="PhylomeDB" id="F9UTR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-259-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="400" mass="43846" checksum="75C824C7EA39BD19" modified="2011-10-19" version="1">MATTLVLGGGYAGMRAVKFLQKSLPTEDEIILVDQTPTHTEKTNLHEVAAGTIAPDRITYQIPDIIGKRVQFVQATVKNVDIEQKQVTFEDHPEMTYDYLVLALGFQSETFGVAGADENALPMDDLATSQAVYEHLEERFKAYRTSKDKNDLKIAVCGAGFTGIELLGELTQTLPRLQAKYQTPAAKLVCLERMPSILPMFTQELRDYALKFMEKNNVEMRLGAVIEAIKPGAVVYSDADKNEHEFTANTIIWTVGVSGSHVIADSGFDQRRNRVVVKPDLSLEGHPEVFIVGDVAAVMDPESNRPYPTTAQIALAAGEQAAKNIGALRHNQATATFHYESSGTVASLSDRDGIGEIFSSNKPVHGYAASALKKIITDRSLLESAHLGTVFSKGRFDLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTU5</accession>
    <name>F9UTU5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888379.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0346"/>
    <dbReference type="EnsemblBacteria" id="CCC77865">
        <property type="protein sequence ID" value="CCC77865"/>
        <property type="gene ID" value="lp_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0346"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.293"/>
    <dbReference type="eggNOG" id="ENOG5030A6W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2437147_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-287-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="10481" checksum="CFA58696336B55A3" modified="2011-10-19" version="1">MDTPLFLNVVAYVLLILVLQYIKFKFPDSTFIRFFQKYGWWLIGLCFVAILVILAAPQFQNPFNALDVPAIGVMLVFGYFFIKDKKSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV9</accession>
    <name>F9UTV9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">accB3</name>
        <name evidence="5" type="ordered locus">lp_0362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888393.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0362"/>
    <dbReference type="EnsemblBacteria" id="CCC77879">
        <property type="protein sequence ID" value="CCC77879"/>
        <property type="gene ID" value="lp_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0362"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.306"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_2_9"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="PhylomeDB" id="F9UTV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-301-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="20446" checksum="00FB6163B015D071" modified="2011-10-19" version="1">MELDKIYQLMDKFEQSSLTSFEYRDQDFEIQMGKKGHGKTTVTPQPAPLPNQPVIDPTPVTPTPVSTVSTPVVAEAEPTPVATSTASNPTSVVTPDPEPEPAPIDPKECVTAPVVGIYYPAHSSEEAPYVKLGDHVSVGQQVGLIQAMQMMRPVVAKQAGTVKAFLVKNGEEVNFGQPLIQLIPDTPDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX4</accession>
    <name>F9UTX4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888408.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0377"/>
    <dbReference type="EnsemblBacteria" id="CCC77894">
        <property type="protein sequence ID" value="CCC77894"/>
        <property type="gene ID" value="lp_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0377"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.320"/>
    <dbReference type="eggNOG" id="ENOG5030B9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187595_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-316-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="10312" checksum="A239F9BA9FDE74E4" modified="2011-10-19" version="1">MLVFIVIGLITAVITIGLGYWSYILGKRNKSNIVGSVIPAGYFIVRLVFVLVLGEGVRELITSLVGNLVITVVYVLLFVWGRQRFNRQKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ7</accession>
    <name>F9UTZ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin peptide PlnN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plnN</name>
        <name evidence="1" type="ordered locus">lp_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0410"/>
    <dbReference type="EnsemblBacteria" id="CCC77917">
        <property type="protein sequence ID" value="CCC77917"/>
        <property type="gene ID" value="lp_0410"/>
    </dbReference>
    <dbReference type="GeneID" id="57024215"/>
    <dbReference type="KEGG" id="lpl:lp_0410"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.336"/>
    <dbReference type="HOGENOM" id="CLU_3026620_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-340-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="5959" checksum="27FF8B4C5F0CB62E" modified="2011-12-14" version="1">MKSLDKIAGLGIEMAEKDLTTVEGGKNYSKTWWYKSLTLLGKVAEGTSSAWHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU72</accession>
    <name>F9UU72_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P3 protein 2, CI-like repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890888.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3389"/>
    <dbReference type="EnsemblBacteria" id="CCC80374">
        <property type="protein sequence ID" value="CCC80374"/>
        <property type="gene ID" value="lp_3389"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3389"/>
    <dbReference type="HOGENOM" id="CLU_1978716_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2862-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="13825" checksum="A8311ACC3BE9127C" modified="2011-10-19" version="1">MSIVSLAKQSGLSVSSISAYENNKRQPKIESLQKISKVLGVSSAYLNGMSEEKNILNVNSQSLKNNTIDIDVIGFLLNVRSTYPGKVPIFIQDVLAGAPIYIDDNGNKLDAKKRKLLITFLKTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF4</accession>
    <name>F9UUF4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator. LacI family, raffinose related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rafR</name>
        <name evidence="5" type="ordered locus">lp_3488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890970.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3488"/>
    <dbReference type="EnsemblBacteria" id="CCC80456">
        <property type="protein sequence ID" value="CCC80456"/>
        <property type="gene ID" value="lp_3488"/>
    </dbReference>
    <dbReference type="GeneID" id="57026702"/>
    <dbReference type="GeneID" id="66450954"/>
    <dbReference type="KEGG" id="lpl:lp_3488"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2904"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_1_2_9"/>
    <dbReference type="OMA" id="VLCAPRM"/>
    <dbReference type="PhylomeDB" id="F9UUF4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2944-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="331" mass="37105" checksum="D04BFE75A049B142" modified="2011-10-19" version="1">MAATLKDIANKVGVSLATVSRVLNKDQSLSVSDTTRQRILDAAEALQYSKNKRHTVTTARKRLAIVQWYSESKEQDDLYYMSVRMGIERRGQDNQFEVTRIFQNNLQELGPDVDAVIAVGKFSEPQVKDLASVTDNLVFVDDDQFDAGFDSVITDFRLATEKVVDYFWQRNFHHIGFIHGQEMTTDHQLAVVDRRMLGFRAAMERRHAFDPKFVFKGDYTSESGFKMMQKAIRKLGDQLPGAFFVANDPMAAGALKALQASGIQVPERVKLFSFNNTSLATFVYPELSAVNVDTELMGATAVNLVISRLAGRTTTQRVELGTNLVERASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH5</accession>
    <name>F9UUH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3509"/>
    <dbReference type="EnsemblBacteria" id="CCC80477">
        <property type="protein sequence ID" value="CCC80477"/>
        <property type="gene ID" value="lp_3509"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3509"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2925"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UUH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2965-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="302" mass="32257" checksum="ADBC5A1EA319C042" modified="2011-10-19" version="1">MTYLIGVDCGGTHIVGQTWTTAPEHLVQSVTGGPGNVVLDYSAAVTNLTTVLDQLTAAIPASQLGLILIGIAGIETAGRADQVQQTITQRYHANTQVISDAKLALLNGLAGADGALVIAGTGSVVYGRQAGKFLRVGGWGYVLGDEGSAYDISKRALKQVLTQTDNGQTSQLTAPLLAQLKVTDIAAAVQKFYAQDRQTNAQLAQLIAKLAEQQNSEAITVLVTSAQALAQQVVTLYQRFAESWPQRVALSGSVLQHNRLVRDTLTTTVHQSIPTIAFNDITTNNAHAVIYWHRWTQEEINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK9</accession>
    <name>F9UUK9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, galactitol-specific EIIB component</fullName>
            <ecNumber evidence="3">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pts35B</name>
        <name evidence="3" type="ordered locus">lp_3547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642909.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891025.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3547"/>
    <dbReference type="EnsemblBacteria" id="CCC80511">
        <property type="protein sequence ID" value="CCC80511"/>
        <property type="gene ID" value="lp_3547"/>
    </dbReference>
    <dbReference type="GeneID" id="57026747"/>
    <dbReference type="GeneID" id="66450994"/>
    <dbReference type="KEGG" id="lpl:lp_3547"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2958"/>
    <dbReference type="eggNOG" id="COG3414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159248_3_1_9"/>
    <dbReference type="OMA" id="VNIIQCK"/>
    <dbReference type="PhylomeDB" id="F9UUK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2999-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="10548" checksum="20A30E79721A3EFF" modified="2011-10-19" version="1">MKKLNVLVACGAGIATSTVVMKKVEDLFAENNIDANLIQIKIAEAASKQDDADMLISTTVLPTEYKIPAIKAMGFLTGLGVDKLQDEILTKAREIQAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU1</accession>
    <accession>F9UQR5</accession>
    <name>ATPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">lp_2366</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101724.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU1"/>
    <dbReference type="SMR" id="Q88UU1"/>
    <dbReference type="STRING" id="220668.lp_2366"/>
    <dbReference type="PRIDE" id="Q88UU1"/>
    <dbReference type="EnsemblBacteria" id="CCC79554">
        <property type="protein sequence ID" value="CCC79554"/>
        <property type="gene ID" value="lp_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2366"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1999"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_9"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="PhylomeDB" id="Q88UU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2038-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238267" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <sequence length="504" mass="54522" checksum="91CC1621D06718A6" modified="2003-06-01" version="1">MSIKSEEISALIKQQLESYQTELSVAETGTVTYVGDGIARAHGLDNALQGELLEFSNGVYGMVQNLESNDVGIVVLGDFDGIREGDTVKRTGRIMEVPVGDAMIGRVVNPLGQPVDGLGEIKTTNTRPIEHKAPGIMQRQSVSEPLQTGIKAIDALVPIGRGQRELIIGDRKTGKTSVAIDAILNQKDQDMICVYVAIGQKDSTVRAQVETLKKLGAMDYTIVVTAGPAEPAPLLYLAPYAGAAMGEEFMMNGKHVLIVYDDLSKQATAYRELSLILRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPIIETQAGDISAYIPTNVISITDGQIFLDSDSFYSGVRPAIDAGASVSRVGGDAQIKAMKSVAGTLRLDLASYRELESFSQFGSDLDAATQAKLNRGQRIVEVLKQPVHSPLKVEEQVMILYALTNGYLDKVAVDDIARYQSELFEFIHASHQDLFDTILATKKLPEADKMNGALDAFAEQFQPTAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ5</accession>
    <accession>F9UP08</accession>
    <name>RS16_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">lp_1636</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638633.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889461.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ5"/>
    <dbReference type="SMR" id="Q88WJ5"/>
    <dbReference type="STRING" id="220668.lp_1636"/>
    <dbReference type="EnsemblBacteria" id="CCC78947">
        <property type="protein sequence ID" value="CCC78947"/>
        <property type="gene ID" value="lp_1636"/>
    </dbReference>
    <dbReference type="GeneID" id="49393902"/>
    <dbReference type="GeneID" id="57025218"/>
    <dbReference type="GeneID" id="66449517"/>
    <dbReference type="KEGG" id="lpl:lp_1636"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1383"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_9"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="PhylomeDB" id="Q88WJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1410-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000167198" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="90" mass="10208" checksum="49B032FC94BDB8C2" modified="2003-05-23" version="1">MSVKIRLKRMGSKKNPFYRIVVADSRSPRDGRFIAQVGTYNPLTEPAQVKLEEEDILGWLNNGAQPSDTVKNILSKAGIMKKYHEAKFTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YH4</accession>
    <accession>F9UM12</accession>
    <name>TPIS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">lp_0791</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YH4"/>
    <dbReference type="SMR" id="Q88YH4"/>
    <dbReference type="STRING" id="220668.lp_0791"/>
    <dbReference type="EnsemblBacteria" id="CCC78251">
        <property type="protein sequence ID" value="CCC78251"/>
        <property type="gene ID" value="lp_0791"/>
    </dbReference>
    <dbReference type="GeneID" id="57024493"/>
    <dbReference type="GeneID" id="66448755"/>
    <dbReference type="KEGG" id="lpl:lp_0791"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.668"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_9"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="PhylomeDB" id="Q88YH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-687-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090234" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="252" mass="26971" checksum="0CAE30AED2036E8E" modified="2003-06-01" version="1">MRTPIIAGNWKMNKTASEALAFVNAVKDQLPDPSKVESVVAAPALFLQEMVEAAKGSDLKIAAENAYFEDAGAFTGETSPAALADLGVDYVVIGHSERRGYFHETDEDINKKAHAIFKNGMKPIICCGESLEQREAGEAESWVSGQIKAALKDLSADQVSSLVIAYEPIWAIGTGKTATSDQAEEICAVVRKTVADLYSQEVADKVRIQYGGSVKPANVNELMGKDDIDGGLVGGASLQPDSFLELVNYQNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z52</accession>
    <accession>F9UKY9</accession>
    <name>RL31B_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmE2</name>
        <name type="ordered locus">lp_0512</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Appl. Environ. Microbiol." volume="70" first="1336" last="1346">
            <title>Heat shock response in Lactobacillus plantarum.</title>
            <authorList>
                <person name="De Angelis M."/>
                <person name="Di Cagno R."/>
                <person name="Huet C."/>
                <person name="Crecchio C."/>
                <person name="Fox P.F."/>
                <person name="Gobbetti M."/>
            </authorList>
            <dbReference type="PubMed" id="15006751"/>
            <dbReference type="DOI" id="10.1128/AEM.70.3.1336-1346.2004"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 1-14</scope>
        <scope>INDUCTION BY HEAT SHOCK</scope>
        <source>
            <strain>DPC2739</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">In strain DPC2739 is induced in mid-exponential phase cells by exposure to 42 degree Celsius for one hour.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888518.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z52"/>
    <dbReference type="STRING" id="220668.lp_0512"/>
    <dbReference type="EnsemblBacteria" id="CCC78004">
        <property type="protein sequence ID" value="CCC78004"/>
        <property type="gene ID" value="lp_0512"/>
    </dbReference>
    <dbReference type="GeneID" id="49392843"/>
    <dbReference type="GeneID" id="57024285"/>
    <dbReference type="GeneID" id="66448560"/>
    <dbReference type="KEGG" id="lpl:lp_0512"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.421"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_9"/>
    <dbReference type="OMA" id="FKDMSND"/>
    <dbReference type="PhylomeDB" id="Q88Z52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-425-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000173232" description="50S ribosomal protein L31 type B">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="81" mass="9135" checksum="30663858D280F79C" modified="2003-05-23" version="1">MQKGIHPDYHLVVFQDSTTGFKFISGSTATSAETVEWEDGNTYPLIRVEITSDSHPFYTGKQKFTKADGAVDRFNKKYGLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q890K5</accession>
    <accession>F9US36</accession>
    <name>RECF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recF</name>
        <name type="ordered locus">lp_0005</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890K5"/>
    <dbReference type="SMR" id="Q890K5"/>
    <dbReference type="STRING" id="220668.lp_0005"/>
    <dbReference type="EnsemblBacteria" id="CCC77583">
        <property type="protein sequence ID" value="CCC77583"/>
        <property type="gene ID" value="lp_0005"/>
    </dbReference>
    <dbReference type="GeneID" id="57026867"/>
    <dbReference type="KEGG" id="lpl:lp_0005"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.4"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_9"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="PhylomeDB" id="Q890K5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-4-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000196424" description="DNA replication and repair protein RecF">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <sequence length="374" mass="42438" checksum="B3A3F131880E5B4C" modified="2003-06-01" version="1">MYLENLVLHDFRNYADLTINFSQGVNVLLGENAQGKTNLLEAIYVLALTRSHRTANDKELIRWQTTTATLQGRLHKSTGAVPLELELGRRGKRAKVNHLEQAKLSQYVGNLNVIVFAPEDLSIVKGAPAVRRRFMDMEFGQMSPKYLYNLSQYRTILKQRNQYLRQLNRQQAKDKVYLGVLSDQLAAFGAEIIHKRLQLLQQLEKWAQAVHSEITQEQEQLTFHYVTQVPTADQTSVDHIYQTLQALYQQQQAKEIFQGTTLLGPHRDDLQFGVNGKNVQTFGSQGQQRTTALSVKLAEIDLMKAETGEYPVLLLDDVLSELDAARQTHLLTAIQDKVQTFLTTPSLDGVARKLINAPKVFEVSHGTLHEEEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV6</accession>
    <name>F9UKV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, DUF218 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0472"/>
    <dbReference type="EnsemblBacteria" id="CCC77971">
        <property type="protein sequence ID" value="CCC77971"/>
        <property type="gene ID" value="lp_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0472"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.388"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_2_0_9"/>
    <dbReference type="OMA" id="FAMFREY"/>
    <dbReference type="PhylomeDB" id="F9UKV6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-392-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="163"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="38538" checksum="4C59D68097C19AF1" modified="2011-10-19" version="1">MTPFYWGSLALASALTLQLTDRRHWLTGHLFLIAVIGILLSAYHRFSAQASPTWQFMLVGAKILAYTLLPIVILIVGISFVRYSYRLIRKEGWAFHYSLLAIVGGVLVIMLVLSVINLGVWHSRRLWQLLGLALLLTAYFAFSFIAYLLACVMTRLGRHRQIDYMIVLGAGLMPNGQPTRTLAYRLQAAAKYYRVQRARYHQPITIVVSGGQGPDEVMAESTAMRQYLVDQGVPRDAIQEENRSTSTIENLKFSHALIVRQQPFYRAVIVTSGYHVLRANIFARQLHLNLTGIGAHTPLYYLPFAMFREYLALIVMYRWANLVVVLGLAAYYVAALVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY8</accession>
    <name>F9UKY8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ordered locus">lp_0511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888517.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0511"/>
    <dbReference type="EnsemblBacteria" id="CCC78003">
        <property type="protein sequence ID" value="CCC78003"/>
        <property type="gene ID" value="lp_0511"/>
    </dbReference>
    <dbReference type="GeneID" id="57024284"/>
    <dbReference type="KEGG" id="lpl:lp_0511"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.420"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_9"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="PhylomeDB" id="F9UKY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-424-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="430" mass="48947" checksum="607B37B872941B24" modified="2011-10-19" version="1">MEKILTMHDLEQKTLKEIYNYAREYKISYYSQMNKKELSLAVLREQDKKRGFVQMEGVLEIISQEGYGFLRPINYGPSQEDIYISQSQIHRFGLRNGDYVAGQARPPRPNERYYGLMRVGTVNGKDPNEAKQRPHFPALTPLYPQKQIKLSTTAAVLATRLIDTFVPIGFGQRGLIVAPPKAGKTTLLKNIANGIVANYPDAKLIMLLIDERPEEVTDLERSIKGEVVSSTFDQQPQNHVRVAELVLERARRLVEDKQDVIILLDSITRLTRAYNLVIPSSGRTLSGGVDPTAFYKPKRFFGSARNIEEGGSLTILGTALVDTGSRMDDMIYEEFKGTGNSELQLSRELAERRVFPALDLKQSSTRKEELLVSRKNLEPVWQIRRSMTGNALEYTEQLLQFLKHTKTNTEFVRDLASLKFTGQSTRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL19</accession>
    <name>F9UL19_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="9">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hprT</name>
        <name evidence="11" type="ordered locus">lp_0546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:25424"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:25426"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:17975"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888548.1">
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    </dbReference>
    <dbReference type="SMR" id="F9UL19"/>
    <dbReference type="STRING" id="220668.lp_0546"/>
    <dbReference type="EnsemblBacteria" id="CCC78034">
        <property type="protein sequence ID" value="CCC78034"/>
        <property type="gene ID" value="lp_0546"/>
    </dbReference>
    <dbReference type="GeneID" id="57024320"/>
    <dbReference type="GeneID" id="66448596"/>
    <dbReference type="KEGG" id="lpl:lp_0546"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.452"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_9"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="PhylomeDB" id="F9UL19"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-455-MON"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00909">
        <property type="reaction ID" value="UER00887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="10">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="180" mass="20318" checksum="176960FA4784DC1F" modified="2011-10-19" version="1">MNNDIERVLYSREDIHQVAQKLGKELTTAYAGKNPLIICVLKGAVLFTTDIIREMDIYADLDFINLSSYGNETISSGEVQLTKDLDADVTGRDVLVIEDIIDTGRTLKFLIDLLKRRDVNSVKVCTLLDKPAGRLVDIKADYIGFEVPNEFVVGYGLDYAERYRNLPYVGILKPAIYEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL29</accession>
    <name>F9UL29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888558.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0557"/>
    <dbReference type="DNASU" id="1064226"/>
    <dbReference type="EnsemblBacteria" id="CCC78044">
        <property type="protein sequence ID" value="CCC78044"/>
        <property type="gene ID" value="lp_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0557"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.462"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_4_0_9"/>
    <dbReference type="OMA" id="IGHTITF"/>
    <dbReference type="PhylomeDB" id="F9UL29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-474-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="31355" checksum="10DB205A59BFAC38" modified="2011-10-19" version="1">MPLYTFIGDIHSAADDLAVLLADPEVAATRLIFLGDYIDGTAARYFGHATESAPLAPLKVLTMVRKRVREYGDVALLGNHDEFWLRTAHGDDNATATWVLNGGHRTWRKLGIYSSNPNHVRRALNGALLKPDTDFLAHLPLMWQHGRLLAMHAGVNWQYPLTQQTTTDLLWIRDDYYDDFTTGSHRWHRNLFNKVIITGHTPVQTLTGSHTGYLKMQADAQDVPRYLIDAGSRSGLFDGGICALTLTVDGEFVRAKRVIKGHRYDGQQIVTPAMLVDQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL62</accession>
    <name>F9UL62_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA carboxytransferase</fullName>
            <ecNumber evidence="3">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accA1</name>
        <name evidence="12" type="ordered locus">lp_0592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0592"/>
    <dbReference type="EnsemblBacteria" id="CCC78077">
        <property type="protein sequence ID" value="CCC78077"/>
        <property type="gene ID" value="lp_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="57024372"/>
    <dbReference type="KEGG" id="lpl:lp_0592"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.496"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_9"/>
    <dbReference type="OMA" id="HINGDDH"/>
    <dbReference type="PhylomeDB" id="F9UL62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-508-MON"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="27338" checksum="38E1F505AEAEDD4E" modified="2011-12-14" version="1">MDKRLQRLRAADRISAPTIIQALLPTMTQQRGDRLLGQDAALTAGFGRTATGRQLAVLGVDRGVDIASRRRKNGGALTVPGYRTALRVVTHAAKFGWPVVSLINMPGADASPQSERYGQSQAIADLIAATGQLTVPNVVVFLGEGHSGGALAFANANRIIMLDDALFNVASPEAVTAILHGQQTSSDAIDLLPMTASALQSRGLVDLVIDHQDQTLVAAINQAIETQLAALEALPAPDLIEQREAKFQHFLQSWPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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    <gene>
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        <name evidence="2" type="ordered locus">lp_0614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640938.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888608.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0614"/>
    <dbReference type="EnsemblBacteria" id="CCC78094">
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        <property type="gene ID" value="lp_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0614"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.514"/>
    <dbReference type="eggNOG" id="COG1595">
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    <dbReference type="HOGENOM" id="CLU_090333_1_1_9"/>
    <dbReference type="OMA" id="CTIFSEY"/>
    <dbReference type="PhylomeDB" id="F9UL79"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-525-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="23370" checksum="A5953F20F3D21CC9" modified="2011-10-19" version="1">MQFLKLVRSEECHVNEQQLIHLAADGDDASINALAQQYVPVVWRLRRQYYVRNFDEDDWLQEGRIAVYRAAKKYQRLRQCSFGTYYRVLLSNQIIDHIRRTQARKRRPEGDILSLDVNDEDILCNIQTLRASTLDVVHVREQVRIFPAICSAFEGLVFMDLLAGQSPERIALSRQVEVDQVVNATDRCRKKMRDFLQDAA</sequence>
</entry>
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    <accession>F9UL98</accession>
    <name>F9UL98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 12, phage transcription regulator</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888627.1">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78113">
        <property type="protein sequence ID" value="CCC78113"/>
        <property type="gene ID" value="lp_0635"/>
    </dbReference>
    <dbReference type="GeneID" id="66450183"/>
    <dbReference type="KEGG" id="lpl:lp_0635"/>
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    <dbReference type="OMA" id="STIWYIE"/>
    <dbReference type="PhylomeDB" id="F9UL98"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
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    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7142" checksum="94FAF2AAB54B60FA" modified="2011-10-19" version="1">MTYTLRIRELRQKLGLSQSALADKSGVPQTTISAIESGTNLTYETAKKLARALGVSTDELSVEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB8</accession>
    <name>F9ULB8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891039.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3562"/>
    <dbReference type="ESTHER" id="lacpl-LP.3562">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80525">
        <property type="protein sequence ID" value="CCC80525"/>
        <property type="gene ID" value="lp_3562"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3562"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2972"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_9"/>
    <dbReference type="OMA" id="FIWATRT"/>
    <dbReference type="PhylomeDB" id="F9ULB8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3013-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="30867" checksum="895605A5B8C10D5B" modified="2011-10-19" version="1">MEIRTLALKTPEGQPFTMWIYQHDQFTLFPDDRLWPLALIFPGGGFAGYSEREVEAVALKFIAKGYQAAVVKYNLTSDGPFYPTAATIGLAALSYVKRHAQELNADFDHVVVSGFSAGGHLVAVMTALGAQSEFLNNHGFEETKLVPFAQILSYPVIDLTMGFPTSQHEMMAVTTDESYWHAQELVTSQTPPTFIWATRTDELVPVVNSLVYLAALGEHNVPFESHIYAAGVHGLAFGDLADSRYHHPEDVVPRVQNWFPMALGWLRTLYASKNSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD0</accession>
    <name>F9ULD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646218.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3575"/>
    <dbReference type="EnsemblBacteria" id="CCC80537">
        <property type="protein sequence ID" value="CCC80537"/>
        <property type="gene ID" value="lp_3575"/>
    </dbReference>
    <dbReference type="GeneID" id="66451010"/>
    <dbReference type="KEGG" id="lpl:lp_3575"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2982"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098232_3_0_9"/>
    <dbReference type="OMA" id="WLHIMYG"/>
    <dbReference type="PhylomeDB" id="F9ULD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3024-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030949">
        <property type="entry name" value="ECF_S_folate_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04518">
        <property type="entry name" value="ECF_S_folT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="182" mass="20611" checksum="5C814FBC1F5E04F0" modified="2011-10-19" version="1">MSKLIAKNVFQLPKMNLLVLTTSAFLLALDVILYKIAIGPAYFQLSFGFLSMACIGYLYGPIWGGLLEMISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLYRKSVNWLSVVMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAIFYFIKALEKRHVFDRMRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULE0</accession>
    <name>F9ULE0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lactate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lox</name>
        <name evidence="10" type="ordered locus">lp_3586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-lactate + O2 = H2O2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:55868"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:55869"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3586"/>
    <dbReference type="EnsemblBacteria" id="CCC80547">
        <property type="protein sequence ID" value="CCC80547"/>
        <property type="gene ID" value="lp_3586"/>
    </dbReference>
    <dbReference type="GeneID" id="57026780"/>
    <dbReference type="GeneID" id="66451020"/>
    <dbReference type="KEGG" id="lpl:lp_3586"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2991"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_6_1_9"/>
    <dbReference type="OMA" id="FQYEIYL"/>
    <dbReference type="PhylomeDB" id="F9ULE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3034-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050040">
        <property type="term" value="F:lactate 2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="38728" checksum="5D7DE8DEB802EE29" modified="2011-10-19" version="1">MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSEDEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGEAATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWDFNQSLLDEAVKAGAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIMEIYAAAAQKISPADVRRITEYTNLPVIVKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRVPIIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQLAGTKTIEDVKRAKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004891090.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3618"/>
    <dbReference type="EnsemblBacteria" id="CCC80576">
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        <property type="gene ID" value="lp_3618"/>
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    <dbReference type="KEGG" id="lpl:lp_3618"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3020"/>
    <dbReference type="eggNOG" id="COG3731">
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    <dbReference type="OMA" id="YCAVHQA"/>
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="PTHR40398"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTSIIA_gutA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="13622" checksum="06DB8E002F18CD02" modified="2011-10-19" version="1">MKTNEAIMYQTNVKEIGQDAQDFSEIKMAIFFGDTAPDALRSSCYLIEVYPVNGVIKPGMSLVVDNEDFEITAVGREVQRNLVNLGHMAVSFTGKQQAELAGTMYVADKELPIISIGSTITIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULP7</accession>
    <name>F9ULP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0659"/>
    <dbReference type="EnsemblBacteria" id="CCC78136">
        <property type="protein sequence ID" value="CCC78136"/>
        <property type="gene ID" value="lp_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0659"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.551"/>
    <dbReference type="HOGENOM" id="CLU_2302328_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-570-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="11564" checksum="21051CEBC99CB5F1" modified="2011-10-19" version="1">MSCHDQFTANTGMSHPNGCKLMPGWIGGTWIRSVVQISMALLVWIKIRRCSMELPANVPKSDELIECLRMERVIDDALHEANKRRAAYYDQKIMDELLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ1</accession>
    <name>F9ULQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P1 protein 40, minor head protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_885073_0_0_9"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-574-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="InterPro" id="IPR006528">
        <property type="entry name" value="Phage_head_morphogenesis_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04233">
        <property type="entry name" value="Phage_Mu_F"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Phage_Mu_F" evidence="2">
        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78140.1"/>
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    </evidence>
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    <sequence length="314" mass="35369" checksum="EC5BD09D5026DA09" modified="2011-10-19" version="1">MDINKLAHALAKILDVKDPVFQQLFALIESSHHSQVKNLTYFLRENVDWNANASEADIKDLTDAVLDLKQNANREEEQVLATLLNNLPYKTNLDVAQAQARVNIANMGLKVNKLVQSKQVDIVQQVTKLTGSGLGGYNTQLRRRALYRVTAQNEPENTSLDLIFKHANKLAIDLDNIIKFQMQNHVNPNSISKIVAKELGVAGKPNPNEDLWETAMQKRYMSTKADMERILVTESKATQTRECAKQYSNLGFTKLKIVTRDNPHVCKYCEGHDGTIVEIKDAVVGMNVPPLHPRCHCNVIPVQMDYKDVLSELN</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888778.1">
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    <dbReference type="STRING" id="220668.lp_0805"/>
    <dbReference type="EnsemblBacteria" id="CCC78264">
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        <property type="gene ID" value="lp_0805"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="F9UM25"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016791">
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        <property type="entry name" value="SSF56784"/>
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        <property type="entry name" value="Cof-subfamily"/>
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        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="31343" checksum="11B88241FC61CE7C" modified="2011-10-19" version="1">MISIIASDMDGTLLNNEMVVSDFNANAIRQAQQQGVHFIVSTGRRFSEAQPLLAAQGITAPLITLNGAEVYDASGKMLDMVPITNSVARTVFHTLTSQGYYFEVVGNDGIYSNSKAKRIEQIAHLLTNLNPDTTFKIAVSLASARLELMDINYVDNYNELLDDPTKHVMKIIAFSEEGPAKLKPLSDEILAKHSSLKITSSSASNIEINNINAQKGIAVERYANMLNTPMSDVMAIGDNNNDVSMLELAGVSYAMGNASPEVKQLARYITDTNVNDGVGKAILEVLAKQ</sequence>
</entry>
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    <accession>F9UM45</accession>
    <name>F9UM45_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78284.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888798.1">
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    </dbReference>
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    <dbReference type="GeneID" id="66448787"/>
    <dbReference type="KEGG" id="lpl:lp_0827"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.702"/>
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        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="102" mass="11941" checksum="6973BD3DFFE3DA46" modified="2011-10-19" version="1">MKNHEVLDLIQEITRNDGTSYMEIGNMLMNGRAELAAERGFIKQVRILQLNIPHSTHVAKYEQYINETFTIPDETMDHWEEWTKTPDMQAEVDLILKENHIG</sequence>
</entry>
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    <accession>F9UM61</accession>
    <name>F9UM61_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">lp_0846</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888814.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78300">
        <property type="protein sequence ID" value="CCC78300"/>
        <property type="gene ID" value="lp_0846"/>
    </dbReference>
    <dbReference type="GeneID" id="58789798"/>
    <dbReference type="GeneID" id="66448803"/>
    <dbReference type="KEGG" id="lpl:lp_0846"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.720"/>
    <dbReference type="eggNOG" id="ENOG5030AM9">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_213842_0_0_9"/>
    <dbReference type="OMA" id="QMMAIGM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-736-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="53" mass="6132" checksum="2FB2C6A59FAFD355" modified="2011-10-19" version="1">MAGSKITAIFFLILYAVLLYLVFTMQNMLAMYLMAIGMFLEACEGVYHNFFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM73</accession>
    <name>F9UM73_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888826.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0862"/>
    <dbReference type="EnsemblBacteria" id="CCC78312">
        <property type="protein sequence ID" value="CCC78312"/>
        <property type="gene ID" value="lp_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="57024553"/>
    <dbReference type="KEGG" id="lpl:lp_0862"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.732"/>
    <dbReference type="eggNOG" id="ENOG503328X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074053_2_0_9"/>
    <dbReference type="OMA" id="ANNEFVY"/>
    <dbReference type="PhylomeDB" id="F9UM73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-748-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="4">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17626" checksum="58DA7F6628E7EACD" modified="2011-10-19" version="1">MGAAIDITGQHFGRLIAVHRAGRAKNGNALWFCQCQCGRTCVVDSYVLRHGKTRSCGCLAVEQSRQNIFNNPQAVSHMGDPRNLKIRDHHTDVSSIKKSKRNTSGVVGVSYDKQSGSWVAHFYYKGTYILNKHFAHFEDAVRARHAMEQQYLTSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM82</accession>
    <name>F9UM82_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0874"/>
    <dbReference type="DNASU" id="1061514"/>
    <dbReference type="EnsemblBacteria" id="CCC78321">
        <property type="protein sequence ID" value="CCC78321"/>
        <property type="gene ID" value="lp_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0874"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.741"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501343_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-757-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh" evidence="6">
        <location>
            <begin position="274"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="7">
        <location>
            <begin position="326"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="543" mass="58001" checksum="7540CF9F9AA00FA0" modified="2011-10-19" version="1">MSINSETLVNHMNHEIAAIQPSDILAFNAEIANIPGIVRLTLGEPDFNTPEHVKQAAIESIEADESHYAPSNGTLALRTAAAEFLAAKYDVHYDPASEVIITAGATGGIYTALTSILNPGDEVLIPTPIFPLYIAIVKLSGATPVFMDTSDNGFVLSPDQLQTTLAAHPKTKAVVLNFPSNPTGVTYRHDDLKALAAVLADQPIFVLSDEIYSELTYGEPHESIANYLPTQTILLNGVSKSHAMTGWRIGIMCAPKAITAQLGKIHQFTVTSTTTNAQAAAAGLKQLTSRTAGVDTIDIPAAKAAGLVVTNVPAYSPNSVAEMSVAQTMRLIRNLEMFDQRISQQNFQWAGLQAREIRSLTVGIIGAGRIGGTAARLFHGLGAKVIAYDVVRHPELEDVLTYVDTKEDLLRQADVVDLHVDLNETSAGLIDAAALKLMKTDAYLINASRGPVIVTDDLVAALKAGEIAGCALDTVEGENALFNQNHQGEVLQDTNVAQLMQMPNVIITPHVGFYTNLAVKNMVDISLDDVLAILNGETTAHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMB3</accession>
    <name>F9UMB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-[acyl-carrier protein] reductase (NADH)</fullName>
            <ecNumber evidence="2">1.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101202.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888866.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0912"/>
    <dbReference type="EnsemblBacteria" id="CCC78352">
        <property type="protein sequence ID" value="CCC78352"/>
        <property type="gene ID" value="lp_0912"/>
    </dbReference>
    <dbReference type="GeneID" id="57024593"/>
    <dbReference type="KEGG" id="lpl:lp_0912"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.772"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_9"/>
    <dbReference type="OMA" id="CDLICAQ"/>
    <dbReference type="PhylomeDB" id="F9UMB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-788-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="32054" checksum="BD938956B98742E5" modified="2011-10-19" version="1">MSITEMLGIQYPIFSGAMMRIATHELVGAVSEAGGLGVLGSAGLSAEQLRAEIQATRKLTDKPFGVNLMLQMKNCPELAQVIIDEGVKVVTTGAGNPTSYIPPLHAAGIKVIPVIASVHHAHKMVAAGADAVVAEGQESGGHIGQTSTMALLPQVVDAVDIPVIGAGGVGDGRSIAAMFALGAQGVQCGTIFLTAEECPVPASYKQRVLAASDTDTIVTGRSQRDPVRALVNPMLAQYLQLEQTNAPVAELHALADGSFAKAVEDGDMEHGTPMAGEVAGMMTTIRPVKEIIMTLFGQAREVAAQLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC9</accession>
    <name>F9UMC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asp2</name>
        <name evidence="3" type="ordered locus">lp_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888882.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0930"/>
    <dbReference type="EnsemblBacteria" id="CCC78368">
        <property type="protein sequence ID" value="CCC78368"/>
        <property type="gene ID" value="lp_0930"/>
    </dbReference>
    <dbReference type="GeneID" id="57024609"/>
    <dbReference type="GeneID" id="66448868"/>
    <dbReference type="KEGG" id="lpl:lp_0930"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.788"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UMC9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-804-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16066" checksum="F430B56B97AA3FFA" modified="2011-10-19" version="1">MEATATSLKPEVVFDDTVLAKIASNTAQEVEGVLSLQGNLIDDISNRFTDKDRPQTGVSVDTDDDDQTVGIELTAILAYGKNGQEILARVADKVAKAVKSMTGYQVTKLKLVVKDMLTTEEWRQQNDKQEKAPEKKHPEPKDDGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD6</accession>
    <name>F9UMD6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdM</name>
        <name evidence="5" type="ordered locus">lp_0939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888889.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0939"/>
    <dbReference type="REBASE" id="6999">
        <property type="entry name" value="M.LplWORF939P"/>
    </dbReference>
    <dbReference type="DNASU" id="1064004"/>
    <dbReference type="EnsemblBacteria" id="CCC78375">
        <property type="protein sequence ID" value="CCC78375"/>
        <property type="gene ID" value="lp_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="57024616"/>
    <dbReference type="KEGG" id="lpl:lp_0939"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.797"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013049_0_2_9"/>
    <dbReference type="OMA" id="YEYLMGM"/>
    <dbReference type="PhylomeDB" id="F9UMD6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-811-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="528" mass="59922" checksum="B06352AF31F35F10" modified="2011-10-19" version="1">MSHIEQAEQQAELQKRLWAVANDLRGNMDASEYRNYILGLIFYRFLSEKVENYANELLQDDDVDFADAEQDADLMQDLKDEVIDVLGFFIEPRYLFTTMVKKINAGDFDVEMLQNAINEVQNSTLGKESENDFKGLFEDLDLQSSRLGNTVAKRSELIAKVILSLSNIDFGEQDIKIDILGDAYEYLIGQFAASAGKKAGEFYTPQQVSKLLARIVTAGKDRLKTVYDPTMGSGSLLLQLGNYATIGNYYGQEINGTTYNLARMNLLMHEVSYNRFDLRQGDTLEEDHFDDLTFDAVVANPPYSAKWNPDDKLDDERFRKYGKTAPKSKADFAFVEHMLYHLNNEGTMAVVLPHGVLFRGAAEGKIRQYMIEHDNVLDAVIGLPANLFYGTSIPTVVLVFKKGRERQDIFFIDASNDFEKGKNQNNLTDENVDKILETLEKREDVDKYAHRAEVAEIVENEYNLNIPRYVDTFEEEPPVDVDKLVKEMGEADAKINDLQSELSGMMADLVATDPVAQQQLEAIKRMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG8</accession>
    <name>F9UMG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate (Isoprimoverose-like)/proton symporter, GPH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylP2</name>
        <name evidence="4" type="ordered locus">lp_0975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0975"/>
    <dbReference type="EnsemblBacteria" id="CCC78407">
        <property type="protein sequence ID" value="CCC78407"/>
        <property type="gene ID" value="lp_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="66448902"/>
    <dbReference type="KEGG" id="lpl:lp_0975"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.830"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-843-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="51324" checksum="D29704EC97F45479" modified="2011-10-19" version="1">MSIFQTWKRRIAYGSTDMAGNIIWQMVSTYLLFYYTTVAGISAAFAGMLFFVVRFIDAFDALIYGYLIDHTHTKYGQSRPYFVWFGIPLGLLAMSLFMIPSFGGNTTMRLVYISITYTFFSLIYSGANTPITSILPSLTDDSVERTKLASARMVMTTIGTSAVAAITLPMVKLLGKGNQSKGFTLWAIILGLVIMGLFIFAFLNLKETNGAQNPDGTTESAESLSIWQSLKGAASNKPWLLLACSFILLQTFWMLRGNSAIFFIKYVYGRPELAPIFLGIGFVSVIGNLSVPFLSQRFKNRNVLQFSLVLGVIGQLLLPIAEKMRSVSLLIAGSVIFLIAMGITFTIVFAMLSDTVDYSTKVLGLNETGFLSAVPMIGAKLGMGIGGFLAGQFLAWGQFNAKAAVQSGRTITFINLAFIWMPIILLAAMIFMMQFYRLDEKELQANKAEAAAKVEPKEDVEYDANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMP2</accession>
    <name>F9UMP2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
            <shortName evidence="10">ECF transporter T component EcfT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ecfT</name>
        <name evidence="11" type="ordered locus">lp_1075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the energy-coupling factor EcfT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888995.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1075"/>
    <dbReference type="DNASU" id="1063416"/>
    <dbReference type="EnsemblBacteria" id="CCC78481">
        <property type="protein sequence ID" value="CCC78481"/>
        <property type="gene ID" value="lp_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1075"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.910"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_2_9"/>
    <dbReference type="OMA" id="NNIMIGR"/>
    <dbReference type="PhylomeDB" id="F9UMP2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-924-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01461">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024919">
        <property type="entry name" value="EcfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="266" mass="30151" checksum="B889AB5AA0000908" modified="2011-10-19" version="1">MMNKLIFGRYIPGDSVVHHMDPRAKLLLSFYFIGIIFIANNWATYALLFAFTLAAIYLSGVKWSFFINGVKPLIWLILFTVILQVLFSASGGHVYFQWGIITISQLGLINGVYIFCRFVLIIFMSTLLTLTTPPLELSDAIEYILMPLKAVHFPVYEVALMLSIALRFVPTLMDETEKIMNAQRARGVDFGEGNIFQQMRAVVPLLIPLFVSSFNRAEDLATAMEARGYQGGEGRSKYRILKWHQRDTWATGCFAILTVALIFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX2</accession>
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        <submittedName>
            <fullName evidence="4">Ribonuclease BN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101278.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1174"/>
    <dbReference type="DNASU" id="1063171"/>
    <dbReference type="EnsemblBacteria" id="CCC78561">
        <property type="protein sequence ID" value="CCC78561"/>
        <property type="gene ID" value="lp_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1174"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.992"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_4_0_9"/>
    <dbReference type="OMA" id="LMMSAMN"/>
    <dbReference type="PhylomeDB" id="F9UMX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1004-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="34610" checksum="62F9D3E5DF5E0DF6" modified="2011-10-19" version="1">MNLKARYPKIAKSLEIIIRRYGQANVSNNAIVLAYYALMSIAPIILIAGNLIARFDLKSGQILAYAQEVIPSNVYQTFKPILVSFLSSGSSSSLSIGILVTVWSASKIIAAIRRSLNEAYGVTDAQNAVWTRIIAFFLTLGLLLLIVGLAIFFTLSQLILDVILNLTNLTRAIIPNWINQLLENKNLITFVGMFVVAMLLYYFVPNAKVKLRYIWTGALVTTIGWIVISQGFRVYIELFAKRITTYQTIGSLIVLMFWLNFSGILLMFGGVVNASVQEWFEHTIEPKSPRMIRRIRRQFFKRKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ3</accession>
    <name>F9UMZ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1195"/>
    <dbReference type="EnsemblBacteria" id="CCC78582">
        <property type="protein sequence ID" value="CCC78582"/>
        <property type="gene ID" value="lp_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1195"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1013"/>
    <dbReference type="HOGENOM" id="CLU_2666540_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1025-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8639" checksum="1F0B9326E4097CC8" modified="2011-10-19" version="1">MPRAKYTTAEKLVILEALRKSGERVGIFAQAHGVDPHTMRDWQALYERDGFAGLAEARKNQHYSQGLSWRRLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN13</accession>
    <name>F9UN13_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2 (GT2)</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3B</name>
        <name evidence="2" type="ordered locus">lp_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101316.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1216"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78602">
        <property type="protein sequence ID" value="CCC78602"/>
        <property type="gene ID" value="lp_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1216"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1032"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_2_1_9"/>
    <dbReference type="OMA" id="KVYYLVR"/>
    <dbReference type="PhylomeDB" id="F9UN13"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1044-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="35430" checksum="86C8E35F9CFB0BE5" modified="2011-10-19" version="1">MQYGAIVVTFNRKQLLIESITALLNQTVPPAKIIIIDNHSTDGTKAELQTADILANPSVDYRYLTKNIGGAGGFARGMQIAAADPNLDWASMSDDDAIFEPDYFEKLIAYQQDHPNRQILTGSVYIEDGRLQADQRNRFTNWSTFQAQAVPEREYRGNFEFDQYTFCGVFMSVAVIKQVGVADAGYFIWWDDCEYAVRTAKLSRPVNVSAAKLIHKTALPSLDFKSKFVPDWRLYYGQRNRLITIKRWRANSLVSLGWLLGFYARLAIQLCGPFYRGYRKMVIRVYLEALRDASREREGLNPNFMPGQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN23</accession>
    <name>F9UN23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannose-specific adhesin, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">msa</name>
        <name evidence="10" type="ordered locus">lp_1229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889126.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UN23"/>
    <dbReference type="STRING" id="220668.lp_1229"/>
    <dbReference type="EnsemblBacteria" id="CCC78612">
        <property type="protein sequence ID" value="CCC78612"/>
        <property type="gene ID" value="lp_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1229"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1043"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270498_0_0_9"/>
    <dbReference type="OMA" id="AHDDYVA"/>
    <dbReference type="PhylomeDB" id="F9UN23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1053-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041495">
        <property type="entry name" value="Mub_B2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17966">
        <property type="entry name" value="Muc_B2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394389" evidence="8">
        <location>
            <begin position="46"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1010" mass="107970" checksum="13E7ED8C36D6F859" modified="2011-10-19" version="1">MLKKDNFGEHKTHYKLYKCGKNWAIMGITLVSLGVGTVTMTRAAAADSEVTNDSASQHVTSISTDASKNQHTSSNVILTNDDKSVSASINQDASASVVNKAVSATSQENSSVQNTSQATSTSKQESSSTKNTSQTTSTSNQEANSAKSINQTTRTSKQESSSTKNTSQTTSTSNQEANSAKSINQTTRTSNQESSSAKNTSQTTSTSSRKINSTKSQAQSLTITTTGKAVRATSTSVKKYSTKTKVSYSTLLQQLRTSKALISDEAALTHVDKDNFLKYFSLNGSATYDAKTGIVTITPNQNNQVGNFSLTSKIDMNKSFTLTGQVNLGSNPNGADGIGFAFHSGNTTDVGNAGGNLGIGGLQDAIGFKLDTWFNSYQAPSSDKNGSEISSTNSNGFGWNGDSANAPYGTFVKTSNQEISTANGSKVQRWWAQDTGESQALSKADIDGNFHDFVVNYDGATRTLTVSYTQASGKVLTWKTTVDSSYQAMAMVVSASTGAAKNLQQFKLTSFDFQEAATVNVKYVDTTGHQLAQGTANYPDGAYVNGRYTTKQLIIPNYRFIKMDDGSVTGTKSLDANGTLIQSGDNGTVIYVYVPEYMAIVKTVNETINYVDENGHALTTSYTANPIHILTVTNPVDGTTTTYYSTITTSIELDATTGRPVDSGWVLGNSQDFDAVTNPQIKGYTVTSTDAPNSDLQHVSAQTVTGDSGDLEFTVVYTKNAPIVTTESKTVNETIHYVYTDGTTAHDDYVAQPITFTRTVFTDAVTGEKTYGGWSAAQQFAAVDSPAIKGYTPDQSKISTQTVTGDSSDLEFTIVYTKNAPTVTTESKTVNETIHYVYTDGTIAHDDYVAQPITFTRTVSTDAVTGEKTYGGWSAAQQFAAVDSPAIKGYTPDQSKISTQTVTGDSSDLEFTVVYKADSTSTKPVKPEQPTIPTTPTEPVKPGQLTTPAKPDQPMTSDKSVQTITIKFVGQRLPQTNETDQQHMTLSGLLLLAMSGLLGLLGMAKRQHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB9</accession>
    <name>F9UNB9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide pheromone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pltA</name>
        <name evidence="1" type="ORF">lp_1354a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1354a"/>
    <dbReference type="EnsemblBacteria" id="CCC78708">
        <property type="protein sequence ID" value="CCC78708"/>
        <property type="gene ID" value="lp_1354a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1354a"/>
    <dbReference type="HOGENOM" id="CLU_2973813_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1166-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="58" mass="6847" checksum="D00CF1497780B9C9" modified="2011-12-14" version="1">MVKIVKFLSHKYTNWPYFATMVVLSIMRGGEQLSFTSIGILQLLTIGTRSCWFFYCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL2</accession>
    <name>F9UNL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter component, iron-sulfur cluster assembly protein SufB, iron regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ordered locus">lp_1472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1472"/>
    <dbReference type="EnsemblBacteria" id="CCC78801">
        <property type="protein sequence ID" value="CCC78801"/>
        <property type="gene ID" value="lp_1472"/>
    </dbReference>
    <dbReference type="GeneID" id="57025101"/>
    <dbReference type="GeneID" id="66449361"/>
    <dbReference type="KEGG" id="lpl:lp_1472"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1234"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_9"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="PhylomeDB" id="F9UNL2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1262-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="468" mass="52587" checksum="BA02B0B4CA603A24" modified="2011-10-19" version="1">MSEVPDVVKNDRDYEYGFHDDVKPAYSTGRGLTEATVREISAAKHEPQWMLDYRLNAYHEYLKMPMPKFGPDLTKLDLKDMLYYQKMTDKKFRDWKEVPADLKRTFDRLGVPEAERKYLAGSSAQYESEVVYHNMRKDFEKLGIIFTDTDTALHDYPELFKKWFGKLVKPTDNKFAALNAAVWSGGSFIYVPKGVQTKTPIQSYFRLNAENSGQFERTLIIVEDGASVDYVEGCTAPNYSSDSLHAAVVEVNVEPNAYCRYTTIQNWSDNVYSLETKRAAAAENATMEWVDGNLGSKVTMKYPSVYLNGEGARGTMLSIAVASNGIHQDSGARMIHNAKNTSSSIVSKSIAKTGGATDYRGTVRFAKHSDGSKAHVECDTIIMDDQSSSNTIPYNEIDSANVAMEHEAKVSKISEEQLYYLMSRGISEAKATEMIIMGFVEPFTKQLPMEYAVELNRLISFEMEGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN8</accession>
    <name>F9UNN8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase, delta chain</fullName>
            <ecNumber evidence="2">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narJ</name>
        <name evidence="2" type="ordered locus">lp_1499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101445.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889341.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1499"/>
    <dbReference type="EnsemblBacteria" id="CCC78827">
        <property type="protein sequence ID" value="CCC78827"/>
        <property type="gene ID" value="lp_1499"/>
    </dbReference>
    <dbReference type="GeneID" id="66449387"/>
    <dbReference type="KEGG" id="lpl:lp_1499"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1261"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084469_3_0_9"/>
    <dbReference type="OMA" id="YLPLMCE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1288-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="21496" checksum="BFF682EAD0D2F2B2" modified="2011-10-19" version="1">MINFKQLTTMQPALVTLSRLIDYPDEMTFATATRQNIVTGYPATAQKAKLLAAFDELAAQPLLAQQAHYAGLFEMNKRYTLYMSFYKMTDSRERGTVLAKLKMMYEMFGLTTVSSELADFLPLLLEFLAYGHFADDPRQQDIKLAFQVIEDGTYTMLQNAAAELDDPYFRLLQVVRAELRTCVETGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR3</accession>
    <name>F9UNR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis GTPase, YqeH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101457.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889366.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1528"/>
    <dbReference type="EnsemblBacteria" id="CCC78852">
        <property type="protein sequence ID" value="CCC78852"/>
        <property type="gene ID" value="lp_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1528"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1286"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017878_0_2_9"/>
    <dbReference type="PhylomeDB" id="F9UNR3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1313-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019988">
        <property type="entry name" value="GTP-bd_ribosome_bgen_YqeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03597">
        <property type="entry name" value="GTPase_YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="1">
        <location>
            <begin position="66"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="378" mass="41706" checksum="0FA83E6E14416411" modified="2011-10-19" version="1">MSETSEETLYCIGCGAAIQTTDPKAAGYTPNSALQKSLASEAQDLYCQRCFRLRHYNEIVPVGLTDDDFRHLLATIRDANALVVYVVDIFDLNGSIIPGLQRFVGDNPVLLVGNKEDVLPRQLRRTKLREWMNQQVRAQGIKPVDVALTSAKKGHSIDELLAMIEKYRRGRDVYVVGVTNVGKSTLINRIIANNTGLKDLITTSRFPGTTLDKIEIPLDDGHMMVDTPGIIHPEQMAHVLSGDDLKLVSPQREIRPKGFQLGNGQTLFLGGVARLDIVDTLKATGTVYVDNNLTLHRTRTENADNFYTKHVGELITPPTGDAVADFPPLVRHEFKVTEISDIVFEGLGWVTVAADTRVAAWAPKGVAVLTRPAMINKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP72</accession>
    <name>F9UP72_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepD4</name>
        <name evidence="6" type="ordered locus">lp_1711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101518.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1711"/>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="CCC79011">
        <property type="protein sequence ID" value="CCC79011"/>
        <property type="gene ID" value="lp_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1711"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1445"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_4_2_9"/>
    <dbReference type="OMA" id="DAKTAWP"/>
    <dbReference type="PhylomeDB" id="F9UP72"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1474-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="479" mass="53493" checksum="3AAF8D65AF2B2864" modified="2011-10-19" version="1">MLTHQFNPYSACTSILVGKNASADGSTMIGRNEDSRAAWAKKMIIHAHREFEEPQTFKSQDQTHPFTMTLPKIRAKYTATPEWTAEYGLFEEDGINEYGVAMSATESAYCNTRVLAADPYVKDGIGEEAMVTVTLPYIHSAREGVERLGHIIEEHGTYETNGILFSDVNEVWYMETGAGHYWVAQRIPDDAYAVVANQLAIQEIDFSDHDNYLYAKDIRNFVLDNQLASMDNGLNFREVFGTADLSDRYYNTPRVWYGQRCFTPSVTQTPESFDLPFIQRADGLIHIDQVQGYLASHYQGTPFDPVGQGTATEKHQYRPISLAKTQESHVLQLRPDLPVTLSGIHWLAMGVAAESVYVPFYAGATTTPAAYQVATEKYDATSAYWIFKHVGILVDAHYHELHGELQTVQKELAIQLGHHIIVTDQQVAALTGDELAMALTKANQKAVDQALNTMQALAADLITKSTDMSPLNYDTDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ9</accession>
    <name>F9UPJ9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dfrA</name>
        <name evidence="9" type="ordered locus">lp_1869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1869"/>
    <dbReference type="EnsemblBacteria" id="CCC79138">
        <property type="protein sequence ID" value="CCC79138"/>
        <property type="gene ID" value="lp_1869"/>
    </dbReference>
    <dbReference type="GeneID" id="57025465"/>
    <dbReference type="KEGG" id="lpl:lp_1869"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1575"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_9"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="PhylomeDB" id="F9UPJ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1600-MON"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="18657" checksum="E1DE065D603FBC14" modified="2011-10-19" version="1">MIALIWAEDQNGLIGNQGQLPWHLPADMQRFKALTTGHHVVMGRKTFAGFKRPLPRRTNWVLSRQSDLKLPPEVHQLADVAAIQTLAAAHPDEPIFVIGGAVVFEAVLPVADYLYRTRINARFDGDTWMPAVDYTQWQLVSQQIGTVDEKNQYPYEFDDFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPM9</accession>
    <name>F9UPM9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889682.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1905"/>
    <dbReference type="EnsemblBacteria" id="CCC79168">
        <property type="protein sequence ID" value="CCC79168"/>
        <property type="gene ID" value="lp_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1905"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1605"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_0_9"/>
    <dbReference type="OMA" id="EVAYDIY"/>
    <dbReference type="PhylomeDB" id="F9UPM9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1630-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="37242" checksum="13AFAECDBE6F8476" modified="2011-10-19" version="1">MQASELIARFEKFAPLKLKWEHDPTGLQIGDPHQDIHKVLVTLDVRPEVVQEAITIGADMIFAHHPVMFRPANNLDYQDPQKAMYAELAAHHILVYAAHTNLDCAEGGMNDWLAAALDLQNVQGLVPGYRAQAVKLTLTVPTNQVETVQEYLTNTVGATLDRYAVNSGEQFSVDLLADQIPTAVAGINDLAADTWDYQVVPLLSGGHQYYMGRVGDLPTPLSAQAFAEQCKQVFGVSGLRLVSADPRQRITRVAVLGGDGGKFYPQALQAGAQAYVTGDVYYHTGHDMLAAGLTVIDPGHHIESICKSQLTKLFDQWRVQAGWPIEIVASQLNTDPFTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN3</accession>
    <name>F9UPN3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein,daunorubicin resistance family A (Drr)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA</name>
        <name evidence="5" type="ordered locus">lp_1910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889686.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1910"/>
    <dbReference type="EnsemblBacteria" id="CCC79172">
        <property type="protein sequence ID" value="CCC79172"/>
        <property type="gene ID" value="lp_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1910"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1609"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="ITAPMAD"/>
    <dbReference type="PhylomeDB" id="F9UPN3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1634-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="313" mass="34032" checksum="AC4A498147452CE8" modified="2011-10-19" version="1">MDEEMMIQMTHVQKRFGTKVAVQDLSLQVQRGEIFGLLGPNGAGKTTVIRMMTTLLRQDAGKILVNGFDSLSQARRVCQQFGLTGQTASIDQDLSARENLQIFGRLNGLSRAAAKHRAMELLTDFDLKHSADHVLATFSGGMRRRLDLAVSLIGKPAILFLDEPTTGLDPRTRAQMWQAIRQLVADGSTVVLTTQYLEEADQLADHIALIDHGQLVASGTPTALKQTVGGQELELEVSATTAVTPAKDILQAMLGQDVRVAERTLTVPLDTASLTPVTEILMRLQAAQITVSNFAMHAPSLDDVFFKLTVGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS7</accession>
    <name>F9UPS7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoD</name>
        <name evidence="6" type="synonym">sigA</name>
        <name evidence="9" type="ordered locus">lp_1962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889730.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1962"/>
    <dbReference type="EnsemblBacteria" id="CCC79216">
        <property type="protein sequence ID" value="CCC79216"/>
        <property type="gene ID" value="lp_1962"/>
    </dbReference>
    <dbReference type="GeneID" id="57025541"/>
    <dbReference type="GeneID" id="66449768"/>
    <dbReference type="KEGG" id="lpl:lp_1962"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1656"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_9"/>
    <dbReference type="OMA" id="YQRWLAE"/>
    <dbReference type="PhylomeDB" id="F9UPS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1680-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
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            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="368" mass="41443" checksum="4C31E09B69349D74" modified="2011-10-19" version="1">MAKAKATTEYDKAVKALIKEYKKTGSIQYDELSDKLAAPYKLDASGIDKLLQKVEDAGISVVDEKGDPDARAVKSVKKVSKKELSDAGSASGIKINDPVRMYLKEIGRVDLLTADEEVALALRIEQGDESAKQELAEANLRLVVSIAKRYVGRGMQFLDLIQEGNMGLMKAVEKFDYRKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRIQRQLLQDLGREPTPEEIGAEMDMPTEKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDQDATSPADAAAYELLKEQLEGVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKQLKDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ19</accession>
    <name>F9UQ19_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79308">
        <property type="protein sequence ID" value="CCC79308"/>
        <property type="gene ID" value="lp_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2064"/>
    <dbReference type="eggNOG" id="COG4912">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079880_3_1_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="53" mass="6065" checksum="62FC1C1F8C5CF8FB" modified="2011-10-19" version="1">MILTNRDDDDSFIQKAIGWALRDYGKVNSEWGRAFVANNVLSSLARREGCKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ27</accession>
    <name>F9UQ27_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate/sulfonate/bicarbonate ABC transporter,ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2076"/>
    <dbReference type="EnsemblBacteria" id="CCC79316">
        <property type="protein sequence ID" value="CCC79316"/>
        <property type="gene ID" value="lp_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2076"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1758"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="AGLYPWR"/>
    <dbReference type="PhylomeDB" id="F9UQ27"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1776-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="29750" checksum="E76A613E1BDD28C6" modified="2011-10-19" version="1">MKKAVLLDVDHVSKSFILSKQRQSELILEAVSLQVQTHQFISIIGSSGVGKSTLLRMIAGIIRPSYGAITFDGNLVTAPNRRMSMVFQNFALFPWLTVRQNIMFGLESQLNSDCQYVDNQIDNLINLIGLKGLKNAYPYELSGGMKQRVGFARALAVEPELLLLDEPFSALDVLTGQRLGQDLITLWERRKFKMQAIVLITHNISEAVRLSDVIYVLGGKPAQIMNTYQIKTPRNQRTEQQIWAKTMAITDQFKRDMNEMRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ69</accession>
    <name>F9UQ69_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2124"/>
    <dbReference type="EnsemblBacteria" id="CCC79358">
        <property type="protein sequence ID" value="CCC79358"/>
        <property type="gene ID" value="lp_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2124"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1799"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_57_3_9"/>
    <dbReference type="OMA" id="GYINNAN"/>
    <dbReference type="PhylomeDB" id="F9UQ69"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1819-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="400" mass="42525" checksum="682ADCCDC8643689" modified="2011-10-19" version="1">MEAMATLTRNFRVLWFGSLITDLGNAMTLPFIVLYIQTLGDYSTTKLNFLGAAAFAVTYACKALVAPLWGRLADQKGRKLMCLRASGMMTLTILGVGLAPNVIVLLILRAAQGAFSGYINNANALISITVPAEQRGQWLSKLVTGSISGTLMGPLLGSLLANTVGYRGAFVATSSLMALVFVMTWWGVQEKVTAVSRATLPPLRPILHQLGGRFICALLTSLLVVQATTNAITPLLSLLVGQLAPQATAQTIILMTGIVAAAPGLATILMAGRVGRILDRLGAGRCLVIFLILAIVDLLLTSLVHQVAWLVGLRLILGIADAALLPALQVMTVEHVPHAAFGRVFSLNQSAQACGNVVGPGLAVIVANWWGYQSIFIVTAGLQLMALMLWVAYFSQQRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC1</accession>
    <name>F9UQC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889924.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2191"/>
    <dbReference type="EnsemblBacteria" id="CCC79410">
        <property type="protein sequence ID" value="CCC79410"/>
        <property type="gene ID" value="lp_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2191"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1851"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_4_3_9"/>
    <dbReference type="OMA" id="MSWLPGA"/>
    <dbReference type="PhylomeDB" id="F9UQC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1871-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="86" mass="9819" checksum="267A6C33CDB3261A" modified="2011-10-19" version="1">MLVTIISRLFQLYQLAIVVYILMSWFPGAYNTRVGQFLGQICEPFLSIFRRFIPAIAGLDFSPIIALLVLQLAESGLFYLITLLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY5</accession>
    <name>F9UQY5_LACPL</name>
    <protein>
        <submittedName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <sequence length="157" mass="18298" checksum="2DDF0FB66C2D8FFC" modified="2011-10-19" version="1">MKWQEMQLLRDTKYSSSENLKKFEDVFKFDKCAVYERPHSLEKLLAGKRSYNAGNKYDTPPYLGEWLDHAELQKVSGTARVVAIAHDYGPADSVHSKIAEHVLSLDLVGVIFDSKVDWYYPGQSLLVMIMSKETYNYYYYDLLANHHVVDVVKKQYY</sequence>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2485"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2586"/>
    <dbReference type="DNASU" id="1062813"/>
    <dbReference type="EnsemblBacteria" id="CCC79735">
        <property type="protein sequence ID" value="CCC79735"/>
        <property type="gene ID" value="lp_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2586"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2171"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_0_0_9"/>
    <dbReference type="OMA" id="SRRIHAQ"/>
    <dbReference type="PhylomeDB" id="F9UR96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2226-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="254" mass="28055" checksum="7062F112FAFC61C9" modified="2011-10-19" version="1">MMRRIKIIKIMAIISATLVVGIGSYWQHRLTPLRKTRVAQTSIPTIFVGGDYARAFSTDGFVHRLTAAHLMTKGLVVHVSHAGHVTVQQFGPLKNNPTIQVIFADNHHAKRQARQFATVMQGLAKRYHVTRYNAVGHSSGGNIIFDYLTAQVPQRAQINKFVTIGSTYPGLTTQQLNRLPRSLPILNIAGHVWHTSGDGGVNLQAVLKFSHQLLAAGWSPKTQIIHGSPLTASHSMLHINPQVDLLIIQFLYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA7</accession>
    <name>F9URA7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101846.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890260.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79746">
        <property type="protein sequence ID" value="CCC79746"/>
        <property type="gene ID" value="lp_2599"/>
    </dbReference>
    <dbReference type="GeneID" id="57026007"/>
    <dbReference type="KEGG" id="lpl:lp_2599"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2182"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054506_1_1_9"/>
    <dbReference type="OMA" id="CTVVQLT"/>
    <dbReference type="PhylomeDB" id="F9URA7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2237-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="60"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="316" mass="35263" checksum="7A2DB81403C802E8" modified="2011-10-19" version="1">MSHNRRQLLAKVAYLYYERDHTQAQIAKELNIYRTTISRMLKQARQLGIVEIKINDFNSDLFALEEQLKQRYHLKKAVVIAGEPHANHQRKEQLLSTEAALYLKQIIKPNNIVGFAWGSILSGMIGQLQHPIQTDATFVPLVGGPSPSNAAYHVNGIVYDAARTFGGHSLFVDAAAVQESKYIRDGILTSNYFRQIRDCWNHLDIALLGIGGPLSNTSSRWRDLLTDTDRELLKERQAIGDCCCTFFDKHGKILTGDLLDRTIAIPLPQLAHVPNSIGIARSLTKAPAILALLKMGVLNTLVTDAETAQRVLDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB7</accession>
    <name>F9URB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890270.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2613"/>
    <dbReference type="EnsemblBacteria" id="CCC79756">
        <property type="protein sequence ID" value="CCC79756"/>
        <property type="gene ID" value="lp_2613"/>
    </dbReference>
    <dbReference type="GeneID" id="57026017"/>
    <dbReference type="KEGG" id="lpl:lp_2613"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2195"/>
    <dbReference type="eggNOG" id="ENOG50309R6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092762_0_0_9"/>
    <dbReference type="OMA" id="LLCWQNE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2247-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="28884" checksum="4A34CE3098716852" modified="2011-10-19" version="1">MTSSWSLFKALSWPRFKQMSLLIGIEALAVIVTSLWTAIKGNFTAATLFYNLCAWMALPLIVGFILLAVSNEKFFRAGTFWLLPISDWRRYTINLVVSLVDIVYVWLVQVILFCLTLWIGWNELMGGLTSASLFFSQFDAGSAVQFALGTLLVLVLVTILIWSTITLCHFVTNATKGFLPRFRQRFVNVIITVVVIYVAFRLANLLISMVSFLSSQLVNQGQIDSLWVGSLVMLAVILVEGVLNTLMLQKWVEPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD1</accession>
    <name>F9URD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin H-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxH</name>
        <name evidence="2" type="ordered locus">lp_2633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642657.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2633"/>
    <dbReference type="EnsemblBacteria" id="CCC79770">
        <property type="protein sequence ID" value="CCC79770"/>
        <property type="gene ID" value="lp_2633"/>
    </dbReference>
    <dbReference type="GeneID" id="66450312"/>
    <dbReference type="KEGG" id="lpl:lp_2633"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2208"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_3_9"/>
    <dbReference type="OMA" id="FIDPFMP"/>
    <dbReference type="PhylomeDB" id="F9URD1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2261-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="12284" checksum="1E55F68CD0462EA6" modified="2011-10-19" version="1">MATATLSDEEIRERIKTGKHMLFFTADWCPDCAFIKPVMPQIEAKYDQYDWITVDRDANIEIAQDMGVMGIPSFVGIEDGQEIGRYVDKFRKTQKQVEDFLDTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH2</accession>
    <name>F9URH2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tauE1</name>
        <name evidence="6" type="ordered locus">lp_2688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644715.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890325.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79811">
        <property type="protein sequence ID" value="CCC79811"/>
        <property type="gene ID" value="lp_2688"/>
    </dbReference>
    <dbReference type="GeneID" id="57026071"/>
    <dbReference type="GeneID" id="66450348"/>
    <dbReference type="KEGG" id="lpl:lp_2688"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2250"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_7_1_9"/>
    <dbReference type="OMA" id="KELKGHW"/>
    <dbReference type="PhylomeDB" id="F9URH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2302-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="26815" checksum="2421E29EE1D7C9B7" modified="2011-10-19" version="1">MFTFGELIVILVVVGIVAGIVSTAAGLASLVSYPVLLALGLPPVTANVTNTVGLVFTSFGAVPASRRELRGHGQELKTLIPLTLVGSIVGAILLFIIPAATFAKVVPFFILIAGILVLIPRHIHIKQPGEIVVTPKWMTALAWLGIFLVGAYTGYFGAAGGVLMLSILSFTSAAPFVVYNAQKNLALGLANIVSAVVYGLQTPIQWRYVLPLGIGFLIGGSLGPRIVRHLPARLLKIVIGIGALGLAASLFKSAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URI8</accession>
    <name>F9URI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645874.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890341.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2710"/>
    <dbReference type="EnsemblBacteria" id="CCC79827">
        <property type="protein sequence ID" value="CCC79827"/>
        <property type="gene ID" value="lp_2710"/>
    </dbReference>
    <dbReference type="GeneID" id="57026087"/>
    <dbReference type="GeneID" id="66450364"/>
    <dbReference type="KEGG" id="lpl:lp_2710"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2266"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_8_2_9"/>
    <dbReference type="OMA" id="WANEMPL"/>
    <dbReference type="PhylomeDB" id="F9URI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2318-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="446" mass="47015" checksum="8D4433EA3A662E1A" modified="2011-10-19" version="1">MKEVSAAPKITNVKAAILGFQHLLAMYSGDVLVPLLIGAALHFSQEQLTYLVSIDIFMCGIATFLQLKRTPLTGIGLPVVLGCAVQAVNPLIQIGKTYGLGTMYGSIIGAGIFIFLIAGLFSKIKNLFPPVVTGSLITIIGFTLIPVAFQNLGGGDTSAKDFGNLQALGIGFLTIAIILLISVFARGFMKSVSILIGILVGTLIAGAMGMVSLKPVAEASWFHLPTLFYFGTPHFEWSSILTMILVSLTTMVESTGVFFALGDITGRKIEGDDLKRGYRAEGIAVILGGLFSTFPYSTFSENVGVVQLSGVKTRKPIYFSAAFLVVLGLLPKIGALATIIPDPVLGGAMVVMFGIVGIQGIRMLAQVDFRNNNNLLVAAVSIGLGLGVTVQTNIFQFLPGALQIMLSNGVVVGSVAAVGLNLLFNRHAAENTVDDESVGLNETEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN1</accession>
    <name>F9URN1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890384.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2760"/>
    <dbReference type="EnsemblBacteria" id="CCC79870">
        <property type="protein sequence ID" value="CCC79870"/>
        <property type="gene ID" value="lp_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2760"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2310"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_0_9"/>
    <dbReference type="OMA" id="ADFFDCK"/>
    <dbReference type="PhylomeDB" id="F9URN1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2361-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="23925" checksum="9A93BEC0E754A679" modified="2011-10-19" version="1">MQDPRIIPAELTTGAFFDILADEDHSLSYIQVSEEDVSHQHIDHPMLDHVHFENVRFTASQFERLDLTDAVFINCDFSNCQFEKASWLRVQFKDCKLVGVDLNEAALNNVAFDHCQLDLAMLCDMRFKTVTFDHCRLNGASFMNNRLTTVKFNETNLDQVAFNDTALKNIDLSTCQFERLELDTAAARGMIVNIDQAAYLAAALNGIKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN5</accession>
    <name>F9URN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG2</name>
        <name evidence="1" type="ordered locus">lp_2764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890388.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2764"/>
    <dbReference type="EnsemblBacteria" id="CCC79874">
        <property type="protein sequence ID" value="CCC79874"/>
        <property type="gene ID" value="lp_2764"/>
    </dbReference>
    <dbReference type="GeneID" id="57026135"/>
    <dbReference type="GeneID" id="66450412"/>
    <dbReference type="KEGG" id="lpl:lp_2764"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2314"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_9"/>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="PhylomeDB" id="F9URN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2365-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="25771" checksum="A03BEA2E202C2842" modified="2011-10-19" version="1">MQFDEYRGQTVLVTGAASGIGLAQVQSFLAQGADVIAIDRQPQPSALVTTSALRYEIADVTDTNALVAAIKSGVNVLGKPTVVCNTAGKLDGYQPTLATDLKTWQDILATDLTSQFIVTNAVLPAMLAAQHGVFVNMASIAGLVGGGGGAAYTAAKHAIIGYTKQLDLDYAAQGIRANCIAPGAIDTPMNAADFAGDGKMAKWVASETPAKRWAQPQEVADLTLFLASQHADYIHGTVVPIDGGWLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS7</accession>
    <name>F9URS7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator of multidrug-efflux transporter, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101924.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2817"/>
    <dbReference type="EnsemblBacteria" id="CCC79916">
        <property type="protein sequence ID" value="CCC79916"/>
        <property type="gene ID" value="lp_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2817"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2357"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_0_0_9"/>
    <dbReference type="OMA" id="HEYILGH"/>
    <dbReference type="PhylomeDB" id="F9URS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2413-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="30260" checksum="F2E2D1F881A37C61" modified="2011-10-19" version="1">MTTDFSIGQLAQLFDIPVATLRYYDEIGLLTPARVNPHSHYRYYGTPQFERLSTIKYLRALGLPLATIADFFAARELSKLTSMLTTQQQQVEAQLRLLTAVQQRINTRLAQIKTAQSANFDVTECVTLPERAMVALRQPYRPQDDIELVIAKLRAQTGATNEIFLGKVALMLDQQAIQAGHFDRYAGICLLFEPGDTVPPHQEHLAAGGYAQRIFHGTHLDAPMQYRQLLADCRAHGWHVAGTAIETALIDYGITDQVAQSVTQIQLPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV3</accession>
    <name>F9URV3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644758.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890456.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URV3"/>
    <dbReference type="STRING" id="220668.lp_2851"/>
    <dbReference type="EnsemblBacteria" id="CCC79942">
        <property type="protein sequence ID" value="CCC79942"/>
        <property type="gene ID" value="lp_2851"/>
    </dbReference>
    <dbReference type="GeneID" id="57026207"/>
    <dbReference type="KEGG" id="lpl:lp_2851"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2384"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_9"/>
    <dbReference type="OMA" id="EWEQMID"/>
    <dbReference type="PhylomeDB" id="F9URV3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2439-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="247" mass="26049" checksum="83817BA5D9540A07" modified="2011-10-19" version="1">MTVKNKVVVITGASSGIGATTAKQLASNGAKVVLGARREERLAALVDEIKAAGGQAAYQVTDVTKSADVQALVKLAQTQFGGLDVIFNNAGIMPTSPISALHTDEWDQMVDINIKGVLNGVAAVMPIFTAQKSGQIITTSSVAGIKSFAGSGVYGATKFAVRNLMEVIRMESAQEGTNIRTVSLYPAAINTELLHTITDKTAKQNMTDFYQQVGISPAAVANVVNFAIDQPEDVNVNEFTIYPTKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY0</accession>
    <name>F9URY0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell growth regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">chpA</name>
        <name evidence="3" type="ordered locus">lp_2882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890483.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79969">
        <property type="protein sequence ID" value="CCC79969"/>
        <property type="gene ID" value="lp_2882"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2882"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2412"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_2_0_9"/>
    <dbReference type="OMA" id="IIWIDFD"/>
    <dbReference type="PhylomeDB" id="F9URY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2466-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13274" checksum="231A071EDEDFE5B6" modified="2011-10-19" version="1">MTYLPKQKDIIWIDFDPQRGREIKKRRPAVVLSSNLYTQNTGFVIVSPITSTMRDLPGYFSLNGYNTHGQIAAAQIYSFDATPRAGRSITYIETMRSADFYHVAQTVYYNFDFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US13</accession>
    <name>F9US13_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80002">
        <property type="protein sequence ID" value="CCC80002"/>
        <property type="gene ID" value="lp_2926"/>
    </dbReference>
    <dbReference type="GeneID" id="57026273"/>
    <dbReference type="GeneID" id="66450538"/>
    <dbReference type="KEGG" id="lpl:lp_2926"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2444"/>
    <dbReference type="eggNOG" id="COG4892">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178322_0_0_9"/>
    <dbReference type="OMA" id="YEHWAGQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2498-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="80" mass="8359" checksum="7E5C412F09EA8DD1" modified="2011-10-19" version="1">MNSATFNQTELAKYNGQDGQPAYVAVDGVVYDVTGVAAWAGGKHHGNLAGQELTAVIDTKSPHGRKVLTGLTVVGQYVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9US53</accession>
    <name>F9US53_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="6">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgP</name>
        <name evidence="7" type="ordered locus">lp_0024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643612.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0024"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77600">
        <property type="protein sequence ID" value="CCC77600"/>
        <property type="gene ID" value="lp_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="57026885"/>
    <dbReference type="KEGG" id="lpl:lp_0024"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.22"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_9"/>
    <dbReference type="OMA" id="WLQIANP"/>
    <dbReference type="PhylomeDB" id="F9US53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-21-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="798" mass="90522" checksum="ED68EF0BA5524736" modified="2011-10-19" version="1">MKLTCAQFKKDFLSEIETLYSTSLSDTSTIGQFIALGQLVRRYNSQSWTRTAKFYRDHHQKQVYYFSIEFLPGRLLASNLLNLNLLTTVKKGLTELGLDFETISQAEPDPALGNGGLGRLAACYMDAMASLKIAGNGNGIRYRYGLFKQVFMDGYQVELPDDWLHHGNVWETRRDNKSCIVQFGGNVWLQPQADGSLQPQSENTEDVLAVPYDVGIVGYHNDITNTLRLWSAELPPSATYSSQDQRDRISEITKVLYPDDSNSAGQQLRLRQEYFFSSAGVQSIVRDFCATHHGIKLLGKKVAIHINDTHPTLVIPEMMRLLMDEHHCSWEVAWTLTTQVMSYTNHTILQEALETWPIDMFKNLLPRIYQIIAEIDRRYREQQTPIFGKALVDQTAPLGNGQVRMAYLAVIGSHSVNGVAPLHTELLKTDVLRGLYQVYPERFNNKTNGIATRRWVQLANQPLAQLIDQTIGSDWRRQPDLLQTLLPYQQDDHFLYQLGQVKLTNKQALAAYVQRTMGIKIRTDAIYDVQIKRLHAYKRQLLHVFEILREYFAIKDHPQQPVVPRVHIFGAKAAPSYHYAKAIIKLINVVADMVNQDPAIGDRLKIVFIPNYGVSIAELIIPAADVSEQISTASKEASGTSNMKLMANGALSLATYDGANIDIMQAAGAENEYPFGLKVNEVYDYYHRGNYHAADFYDADPELKRLLDSLIDGTIPGIPTVGREIYDSLLRYNDEFFVLADYRAYVTQQQQISRDFQNQPTWQQRSLANIAASGHFAADLAVARYADDIWQVPHERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9US58</accession>
    <name>F9US58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein, FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641653.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888119.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0030"/>
    <dbReference type="DNASU" id="1061251"/>
    <dbReference type="EnsemblBacteria" id="CCC77605">
        <property type="protein sequence ID" value="CCC77605"/>
        <property type="gene ID" value="lp_0030"/>
    </dbReference>
    <dbReference type="GeneID" id="57026890"/>
    <dbReference type="GeneID" id="66448183"/>
    <dbReference type="KEGG" id="lpl:lp_0030"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.27"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129795_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-26-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="17202" checksum="2FEAD5A094D9E236" modified="2011-10-19" version="1">MQHTTRQAALHMIQTAPVFTLATVDADGFPTMVALSPLPIKRSLEELYFYTSRQTSTTQNIQNWRQASLFYYQLSDYASIMLRGKLSLVGTNVFEQDWRAELTDFQQQLNYKDPVILRFQTSSIKIRQMMTIDHLELVDQPTDGPAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9US71</accession>
    <name>F9US71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrobenzoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pnbA</name>
        <name evidence="2" type="ordered locus">lp_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888132.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0050"/>
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    <dbReference type="EnsemblBacteria" id="CCC77618">
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        <property type="gene ID" value="lp_0050"/>
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    <dbReference type="KEGG" id="lpl:lp_0050"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.40"/>
    <dbReference type="eggNOG" id="COG0778">
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    <dbReference type="HOGENOM" id="CLU_070764_9_1_9"/>
    <dbReference type="OMA" id="MFLQNIM"/>
    <dbReference type="PhylomeDB" id="F9US71"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80097.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="PhylomeDB" id="F9USG7"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidase_M20"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
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        <property type="entry name" value="SSF55031"/>
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    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="184"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="399" mass="42993" checksum="E74ED60928DC6A0E" modified="2011-10-19" version="1">MTLQAQLMQQLTAAEPEMIKIRRHLHAHPEISFHEEQTAAYIKAFYRELGVSTTAYGDGYGFVVDIDSGHPGPQLALRADFDGLAIQEDNHLSFKSQNANVMHACGHDGHTAYLMVLAKTLLGLKNQLRGRVRIIHQPAEEVSPGGAKGMLAAGVLDGIDNVIGLHVMSTMPTGSIAYHLNATQTGRANFTVTFTGKGGHASMPHLSNDAIVAGSYFVTALQTVVSRRIDPFDTGSVTIGSFDGVGSFNAIKAQVTLKGDVRIMDETTRQTIRDQITKIANGVGATFGVQVALDYDDNYPVLMNDATLTQRVITSIQAAQIPEITKIFDCGPQDPSEDFAYFAQAKPSTFIYAGCQTAPGETHPHHSPDFMMNEDCLLIAAKAVGTAALDYLMNASSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH1</accession>
    <name>F9USH1_LACPL</name>
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        <submittedName>
            <fullName evidence="6">Amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3049</name>
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    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3049"/>
    <dbReference type="EnsemblBacteria" id="CCC80101">
        <property type="protein sequence ID" value="CCC80101"/>
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    <dbReference type="KEGG" id="lpl:lp_3049"/>
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    <dbReference type="eggNOG" id="COG0531">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020854_2_1_9"/>
    <dbReference type="OMA" id="FMWFASY"/>
    <dbReference type="PhylomeDB" id="F9USH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2594-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="40"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="225"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="323"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="494" mass="54385" checksum="E0C344FF8BA61B6D" modified="2011-10-19" version="1">MATKDNEKITLMALVMMIFTTVFGFANSTVAYYLMGYSSILFYLVAAVLFFIPFALMMAEFGAAVKSDSSGMYKWLEVSVNAKFAFVGTFMWFASYIIWLVSTSAKVWIPFTTIFFGSDQTQRFAMFGLNATQMIGILSCLWMVLVTFVSIKGMKGIVRVTSLGGLAVTSLTAILLVVSGVVLALNHGQFAQPLQHVMTSPNPSYQHPVGLLGFAVFAIFAYGGLEVLGGMVDKTKNPEKTFPRGIIISAIVITLGYGLGIFCWGISTNWQAVLSNPTTNLGNISYVMMQNLGYVLGQALGLSTAAAKTMGLWFARYTGLGMFLAYSGAFFTLTYSPLKTLILGTPKELWPKKFTKLNKAGMPSYAMMVQCAIVIVIILVASFATADASAFYNVLTLMANVSMTLPYLFLLYAFPKFKENQNIVKPFEVYKSLTWTKIISWVVFIVVLGANVFTLIQPILETGQIQNTIWMLVGPIVFGVAGIIWYQVRERHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL7</accession>
    <name>F9USL7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron chelatin ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fhuD</name>
        <name evidence="3" type="ordered locus">lp_3103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890661.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3103"/>
    <dbReference type="EnsemblBacteria" id="CCC80147">
        <property type="protein sequence ID" value="CCC80147"/>
        <property type="gene ID" value="lp_3103"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3103"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2593"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9USL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2640-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388127" evidence="1">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="34137" checksum="F5B25DFB793BA019" modified="2011-10-19" version="1">MTKRWQIVKLGLVLGLMGSLLLGACGAKQPTSTTVTRTDYLKHKVKVPKHPKRIVASYLEDDLVALGIKPVVQWSVKNGSGTQAYLKEQLKGVPLIDYSLPYEAVTKAKPDLILIGTSSAVANGKYAQYNKIAPTYVVKNGTTVTWRQTFLDVAKVVNRQAKAKKVLAKYDKQVQTTRQALKKSGQHKVAVLWVTNNTAYMVNDNSASGALLYQDLQLGEPSLVKQVSKSATADWSAVSLEKLAKLDADDIFLVNSQKSASLFKDPLWKNIKAVKNNHLYQYGDSSSWQYSGPIAYSQMIDMVKTDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM4</accession>
    <name>F9USM4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890668.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3111"/>
    <dbReference type="EnsemblBacteria" id="CCC80154">
        <property type="protein sequence ID" value="CCC80154"/>
        <property type="gene ID" value="lp_3111"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3111"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_4_9"/>
    <dbReference type="PhylomeDB" id="F9USM4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2647-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="18014" checksum="1C2E0323A4F3E495" modified="2011-10-19" version="1">MQTIQPIVDANQRRIQALNVTREPSEIRERLAEITGQTIDISVEIRVPLWTDYGRNLKIGKRVFINDNVQITDLGGIKLADDVLIGPGAMLLSVNHPLDPAKRHAVEVQPIHIERNAWIGAGAKVLAGVTVGENAVVGAGAVVTKSVPANTVVAGVPAKVIKTIEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN4</accession>
    <name>F9USN4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890678.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3123"/>
    <dbReference type="EnsemblBacteria" id="CCC80164">
        <property type="protein sequence ID" value="CCC80164"/>
        <property type="gene ID" value="lp_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3123"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2611"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_1_9"/>
    <dbReference type="OMA" id="YKSQPWG"/>
    <dbReference type="PhylomeDB" id="F9USN4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2657-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="31168" checksum="F903BE61E8EEC090" modified="2011-10-19" version="1">MFQDIQPHVLKNQNDQQRAPRSGDYILIGRQQQVLLMNGTLPKYEDIDADYAFSPDQYQYLLAVDQAAFFWVDVDAVANDNYTVGTTRGFRDLTPAWLAFSSATAAHLAWWYDTKRFCGHCGQPLHPGATERSLVCAACGQTIYPTIMPAIIVGVTNGDKILMTKFLSGYNHFSLISGYTEIGETFEDTVRREVFEEVGLEVHNIRYFGSQPWAPSHSLLAGYFADLNENVAIELETDELSKAQWFQRDQIPHNDTNTSLTWTMIEAFRHHQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS3</accession>
    <name>F9USS3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spectinomycin 9-adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63228"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:146260"/>
            <dbReference type="ChEBI" id="CHEBI:146261"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888168.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0098"/>
    <dbReference type="DNASU" id="1061376"/>
    <dbReference type="EnsemblBacteria" id="CCC77654">
        <property type="protein sequence ID" value="CCC77654"/>
        <property type="gene ID" value="lp_0098"/>
    </dbReference>
    <dbReference type="GeneID" id="57026940"/>
    <dbReference type="KEGG" id="lpl:lp_0098"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.78"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071584_1_0_9"/>
    <dbReference type="OMA" id="VRPWRYP"/>
    <dbReference type="PhylomeDB" id="F9USS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-76-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024172">
        <property type="entry name" value="AadA/Aad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000819">
        <property type="entry name" value="Streptomycin_3-adenylyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4111" evidence="6">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="259" mass="29106" checksum="4A774DB0ADB45B17" modified="2011-10-19" version="1">MMTSTPRLLQAIQQTTTAILKTNLVGIYLHGSYVLGSYNEQVSDLDYLIVVRRSLTLAEKRQLMTATITQLWPLAPHKGLEFHVLLLSATQHFVHPCPFDFHFSKYHYEDYQRTPLAYLKAMHGTDPDLAAHLTILQAAGQVLLGPAITTVFGPIPAVAYWDSIKSDIANAETAIVQLPMYTVLNLCRVRAYQQDQLIISKQAGGEWGLQQLPTQWHPLIRQALAAYAGQQDEQVIRWSRPNLVAFARIMLAELGLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU3</accession>
    <name>F9USU3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transport protein, APC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641725.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888188.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0120"/>
    <dbReference type="EnsemblBacteria" id="CCC77674">
        <property type="protein sequence ID" value="CCC77674"/>
        <property type="gene ID" value="lp_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="57026960"/>
    <dbReference type="KEGG" id="lpl:lp_0120"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.98"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_9"/>
    <dbReference type="OMA" id="CIAYMNV"/>
    <dbReference type="PhylomeDB" id="F9USU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-96-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="10"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="454" mass="49616" checksum="71191A5C974CCDD3" modified="2011-10-19" version="1">MQRKLSTGQMQMIALGGTIGVGLFMGSSSTIKWTGPSVLIAYIVSGAFLYLIMRALGEMLYVDPNTGSFAKFASEYIHPVFGYLTAWSNIFQFVVVGMSEMIALGGYCRYWWPNLPDWIPGLIAIVFLCAANLISVKMFGTLETWFSLIKVVTIILMIIAGLGLIIFGIGNGGHPIGISNLWTHGGFFTGGVKGFVFALAIVLASYQGIELIGVTAGEAENPQSTIVKAIRSTVARILIFYVGAIFVIVSIYPWDKLSQIGSPFVQTFAKIGITAAASIINFVVITASLSGTNSGIYSASRMTYTLAESHQLPRKMTLLNRHGVPFYSVIAIATGILIGVVLNVVLPMFFKDASEIFVMVYSSSVLPGMVPWFVILVSQIAFRKQNAAKMANHPFKMPLSPYSNYLTLAFLALTLVFMFINPETRYSILVGVVFLVIMTLIYFRKYAGNKEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX2</accession>
    <name>F9USX2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641755.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0159"/>
    <dbReference type="EnsemblBacteria" id="CCC77703">
        <property type="protein sequence ID" value="CCC77703"/>
        <property type="gene ID" value="lp_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="57026990"/>
    <dbReference type="KEGG" id="lpl:lp_0159"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.128"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_9"/>
    <dbReference type="OMA" id="PPDMVHY"/>
    <dbReference type="PhylomeDB" id="F9USX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-125-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="28712" checksum="1B4396D575D9DC86" modified="2011-10-19" version="1">MEMGLAGKRVLVTGSTKGIGRAIAVAFAKEGADVVINGRRADTVAAVVDELAAAYPTTHPVAAPYDISDPQQADKMFQQIPTVDVLVNNMGIFGPMAYDEIDDATWERFFKVNVLSGNRLAKHYLPAMLAQDFGRIIFIASEEAVMPSGEMPQYSMTKSMNLSLAKSLSKLTVGSHVTVNTVMPGSTLTEGVQKMLDDMYADSDLPKDQWEHDFMINHRPLSQIQRLIRPEEIGRLAVFVASPFASSFSGEALRADGGLVPTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY5</accession>
    <name>F9USY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family, maltose related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888230.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0173"/>
    <dbReference type="EnsemblBacteria" id="CCC77716">
        <property type="protein sequence ID" value="CCC77716"/>
        <property type="gene ID" value="lp_0173"/>
    </dbReference>
    <dbReference type="GeneID" id="57027003"/>
    <dbReference type="KEGG" id="lpl:lp_0173"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.141"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="OMA" id="RGCTQAL"/>
    <dbReference type="PhylomeDB" id="F9USY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-138-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="36191" checksum="2261D6F13590F972" modified="2011-10-19" version="1">MITLNDVAKKANVSKMTVSRVINHPEQVRPELREMILNVMTQLDYHPNAAARALVGRRTRVVKLTIFEDMDTTEPYYMMLLAGIANELNQHQYALQIATRNSYEVGECDGYILTGIRQADYAWVERLNQPVVFVGSNRQGYDYVDTNNYQAVWESTRYAAEQGYTHLVFIGIAIAEPFELDRERGFREYVTTHHISAQIIRLANHSHVATAYVKSHWSGFPRNTAFICASDRLAIGVETAIINQGGRVPIEYGIIGFDGVLLNQIAAKRLTTMKQPLEAMGRAAARLLLANINHTDRSRGRHDQEKIIINSRLSVAESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ8</accession>
    <name>F9USZ8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3 8">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">scrB</name>
        <name evidence="12" type="ordered locus">lp_0187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100912.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888243.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0187"/>
    <dbReference type="CAZy" id="GH32">
        <property type="family name" value="Glycoside Hydrolase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77729">
        <property type="protein sequence ID" value="CCC77729"/>
        <property type="gene ID" value="lp_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0187"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.154"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_7_1_9"/>
    <dbReference type="OMA" id="IMYTGNV"/>
    <dbReference type="PhylomeDB" id="F9USZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-151-MON"/>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="10">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="11">
        <location>
            <begin position="345"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC77729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="501" mass="56724" checksum="9267AD9F02A03A75" modified="2011-10-19" version="1">MIWNRKTRYTPYEQWPATKLPQLVAQVRQSKWRMQHHIQPTSGLLNDPNGFSYFDGQWHLFYQVFPFGPVHGLKSWQHVTSKNLVDWHDEGLAIRPDTPYDSHGAYTGTALPIDDQLFIMYTGNVRTADWQRESYQLGAWMDTDNHIKKLSRPLIAHAPAGYTSSFRDPDLIRTDHGYYALIGAQTTTEIGAILVYFSKDLTTWTCQGELNVPANARGYMIECPNLVWIDQQPVLLFCPQGLSQTTTPYQNIYPNMYLVADQLDLAQAQFTEPHALTQLDDGFDVYATQAINAPDGRALAVSWIGLPEISYPTDRENWAHCLSLVKELTLKDGHLYQNPVAAVDDLRTTAHDLVFEQQRATVAALNGSFELLLTVPADKTVTVNIADQQESGQLQVTVDANHGQVMIDRRHTGNSFAEDYGQTRQVELTAHKTIKIRLIIDVSVFECYIDNGYSVMTGRFFLNATPSRLNVQGDTTAVTGKVWEWRQSEHTGVDNNETKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT15</accession>
    <name>F9UT15_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641800.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888260.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0208"/>
    <dbReference type="EnsemblBacteria" id="CCC77746">
        <property type="protein sequence ID" value="CCC77746"/>
        <property type="gene ID" value="lp_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0208"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.172"/>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128703_1_0_9"/>
    <dbReference type="OMA" id="PKCGREF"/>
    <dbReference type="PhylomeDB" id="F9UT15"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-168-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="116" mass="13489" checksum="6C8151C94E48AB40" modified="2011-10-19" version="1">MTPIEAYIANTPQAYQSQLIALQQTIATVLPEAQEQLKYQMPTFYWHENVIHFALFKHHFGLYPTPSAIETFHDQLITYKTSKGAIQFPLDQPLPLELITAITEFRRHEIIAKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT43</accession>
    <name>F9UT43_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100931.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888288.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0244"/>
    <dbReference type="EnsemblBacteria" id="CCC77774">
        <property type="protein sequence ID" value="CCC77774"/>
        <property type="gene ID" value="lp_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="57027064"/>
    <dbReference type="KEGG" id="lpl:lp_0244"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.201"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_9"/>
    <dbReference type="OMA" id="PADWTAF"/>
    <dbReference type="PhylomeDB" id="F9UT43"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-196-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="182" mass="19632" checksum="CA035A3EB6CD1BE0" modified="2011-10-19" version="1">MTKYGVIVGSIRKNSYSKGVAEAIVAGLPDDAEVTYLNIAKLPLYNQDYDADSPVEYTEFRQAVAAQDAFIFVTPEHNRSIPAALKNALDVASRPWGQSVWGGKPALVASQSISGISGVLAHHVLRQSLVFLDMPTMQQPELYIGNTDKLADENGHITNEGTQSFLAGAGKQFSEFAAKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT88</accession>
    <name>F9UT88_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80206">
        <property type="protein sequence ID" value="CCC80206"/>
        <property type="gene ID" value="lp_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3175"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2654"/>
    <dbReference type="eggNOG" id="ENOG502Z95J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071494_1_0_9"/>
    <dbReference type="OMA" id="IINATHW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2694-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="33458" checksum="960B1CEEC891EEA0" modified="2011-10-19" version="1">MDLKQSDGWRYLAGWSFILLMVASATLQHDAKIILPEIGALTAGTWVYRKTAWTRQPLKLFLVPSGTAIIGFLVNQLPWSHALKVLVGLLLMLLLLKGLKSNLAPAFATGLLPIIINATHWTFIVAIFFWTICLMIGAWIQRPRSISRVTEASASRWQMLGFISLVFVWVGIVWLAGQPQMAAIPPVIVVFFEAAQQSEYTVTTALKQWLALSAAASIGVGIHLLIASWLLTTVIALPLVYLWLRALNLQLPAAYAFPLLALVLPANMFNKLPTSAGLAAAFFLGSLLIYHQILGWVRMAVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA8</accession>
    <name>F9UTA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chomosome partitioning protein,membrane-associated ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">parA</name>
        <name evidence="3" type="ordered locus">lp_3199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3199"/>
    <dbReference type="EnsemblBacteria" id="CCC80226">
        <property type="protein sequence ID" value="CCC80226"/>
        <property type="gene ID" value="lp_3199"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3199"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2674"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_9"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="PhylomeDB" id="F9UTA8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2714-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="27786" checksum="0346A811C2BF4409" modified="2011-10-19" version="1">MGTVIALANQKGGVGKTTTSINLGASLVELGQKVLLIDTDAQGNATSGLGVQKSTIEREIYDVLINDVSIKETIIPTSHKGLDIVPATIQLSGAEIELTPMMARETRLRDAIDDVKDDYDYILIDCPPSLGLLTINAFTACDSILIPVQSEYYALEGLSQLLNTIKLVQKHFNKQLRIEGVLLTMYDARTNLGAQVNEEVRKYFKDAVYKTIIPRNVRLSEAPSHGLSIVDYDARSKGAQVYLALAKEVLAAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK0</accession>
    <name>F9UTK0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642841.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890832.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80318">
        <property type="protein sequence ID" value="CCC80318"/>
        <property type="gene ID" value="lp_3321"/>
    </dbReference>
    <dbReference type="GeneID" id="57026582"/>
    <dbReference type="KEGG" id="lpl:lp_3321"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2769"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2569551_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2809-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="81" mass="9244" checksum="027C84FC401959D8" modified="2011-10-19" version="1">MSTAPLSSFEKNIPAVTELLAVDAELQTFFVALTPGYQREWARFIFGTKAQATKERHIEVMKTVFRAGYKSKRAYDSRPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK5</accession>
    <name>F9UTK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="DNASU" id="1063947"/>
    <dbReference type="EnsemblBacteria" id="CCC80323">
        <property type="protein sequence ID" value="CCC80323"/>
        <property type="gene ID" value="lp_3330"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3330"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2775"/>
    <dbReference type="eggNOG" id="COG2315">
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    <dbReference type="HOGENOM" id="CLU_105851_3_0_9"/>
    <dbReference type="OMA" id="YPAFHMN"/>
    <dbReference type="PhylomeDB" id="F9UTK5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2814-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
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    </dbReference>
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        <property type="entry name" value="YjbR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="222" mass="25535" checksum="5C93B29547F38F85" modified="2011-10-19" version="1">MARVRFENKRVNMSKLSQFGFEPNQNGQYQFRILIMQGQFEMIIELNTDGSLNTTLTDTTTSEVYVLHLTSQAHGQFVGQVAQAYQDVLYNIEQHCYDNDVFQSTPERKLIAQVKAAYGDDLEFLWPKFPQNAVWRRSDTHKWYGALLTVTSDKLALPGATHVVTVLDLRARPEDLSMLIDGQHYLPGYHMNKKHWYSILLDDVVPLATIMDDVKVSYMLAK</sequence>
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        <submittedName>
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        <name evidence="2" type="ordered locus">lp_3335</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890842.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3335"/>
    <dbReference type="EnsemblBacteria" id="CCC80328">
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        <property type="gene ID" value="lp_3335"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="40531" checksum="6F181225D10B38EC" modified="2011-10-19" version="1">MILMMMNNPTMLSYIRREQPVLERLLTNYPKQITAALTATPDHPQHWLILATGSRLNAANTARLYMQKTAALQVTIAAADLYVTYEEADPSVDVVIGISLKDDDPTMQAAIEKAHTASQAHVIIVTNQKSTALTAMADATCDLLTGKESVPYITLSFQAIVLTLMLLAVRSAALQARLTELAINQELDEFSFLIESMNPTVQRANDFYRKFTIDFTNAPQFTAIGANVLAGTLTEMQAKFTEILRVPTHGYSLASFTHGGFMGTHEDHCQFYLEINTDPAVMTQLQAVKTYESRLTPHIYTISLTGDQPTVNDDQTLQLEAVADPYKAPLLAIIPFQVLAWFIAKSRGINLNHPMYADFQAATKLK</sequence>
</entry>
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    <accession>F9UTP8</accession>
    <name>F9UTP8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0293</name>
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    <organism evidence="3 4">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77818.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="protein sequence ID" value="CCC77818"/>
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    <dbReference type="GeneID" id="66448385"/>
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        <property type="reaction ID" value="UER00884"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NT_sf"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
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            <end position="191"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="230" mass="26277" checksum="14FF197151117D5E" modified="2011-10-19" version="1">MSTTNSQASADNDQLLPAPPELLQAVDQLKAYSLRYEVAMKLVLDKLDYISREYELRYGYALIDSKQSRIKSPESIVGKMQRKHLPLTLNAVFNNLHDIAGIRLIVRFLSDVKTVENLLATQADIKVLRVKDYIHHPKANGYQSLHLILGVPVYTVDGPSIIEVELQVRTIAMNFWASLEHELNYKKNVPHQDALRASLTKKAQLITELDQEMDDIKQRMYEPKTPPKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX9</accession>
    <name>F9UTX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888413.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0384"/>
    <dbReference type="EnsemblBacteria" id="CCC77899">
        <property type="protein sequence ID" value="CCC77899"/>
        <property type="gene ID" value="lp_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0384"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.324"/>
    <dbReference type="eggNOG" id="COG5444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196715_0_0_9"/>
    <dbReference type="OMA" id="DVDENWW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-321-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="91" mass="10194" checksum="BC062EA279DA54BD" modified="2011-10-19" version="1">MTNLVRYNDIYTMITGKVAVTGKKCLCLAGVAWTSLNSVPVSGKQRSEVEYMDVDENWWHESVLKEFHKGGKPNPDFNPKASKNTHIPVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ5</accession>
    <name>F9UTZ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin peptide PlnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plnJ</name>
        <name evidence="1" type="ordered locus">lp_0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888429.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTZ5"/>
    <dbReference type="STRING" id="220668.lp_0406"/>
    <dbReference type="EnsemblBacteria" id="CCC77915">
        <property type="protein sequence ID" value="CCC77915"/>
        <property type="gene ID" value="lp_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="57024213"/>
    <dbReference type="GeneID" id="66448491"/>
    <dbReference type="KEGG" id="lpl:lp_0406"/>
    <dbReference type="eggNOG" id="ENOG5030BEW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3026611_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-338-MON"/>
    <dbReference type="EvolutionaryTrace" id="F9UTZ5"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="6072" checksum="9CD9236AA0BC67D6" modified="2011-12-14" version="1">MTVNKMIKDLDVVDAFAPISNNKLNGVVGGGAWKNFWSSLRKGFYDGEAGRAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU92</accession>
    <name>F9UU92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890908.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3413"/>
    <dbReference type="EnsemblBacteria" id="CCC80394">
        <property type="protein sequence ID" value="CCC80394"/>
        <property type="gene ID" value="lp_3413"/>
    </dbReference>
    <dbReference type="GeneID" id="57026640"/>
    <dbReference type="KEGG" id="lpl:lp_3413"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2843"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_0_1_9"/>
    <dbReference type="OMA" id="APNSSMN"/>
    <dbReference type="PhylomeDB" id="F9UU92"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2881-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394342" evidence="2">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="168"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="38468" checksum="FEEFD9595CEB691A" modified="2011-10-19" version="1">MNGWNKKLLLGMLTLIMTLLAGMTVIGHAADTANNAVTFDVQPMLNEKQQLSKDAYYWDFKIQPKRTYSLAMRVNNRSNHEIKVKNQFLQSYTNAKGVIDYGAANLNDDTSLKVKLADIITVPNEETTIPANKSRIVRAQLKTPTKLNKGIILGSWQVKIADQHLKTKGATLTSEYAYNVGIKLTSNRDPLPKLRLADVQLKKRSGIKTVIGNIQNYHASILGKGTVTAYVSKAGQTKKLAVADLKSSSMAPNSNFDLPLKWRTNRGIILPGTYTLYVKYRTTDEKFAKPHVWSLKQDFVVGATDAVNVTSPTTWGWLIGIVLLVLLLIALIIFWVIKRRQNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF2</accession>
    <name>F9UUF2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS regulated carbohydrate transporter, GPH family, raffinose/melibiose/galactose (Can switch between symport (H+) and antiport (Lactose))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rafP</name>
        <name evidence="15" type="ordered locus">lp_3486</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the sodium:galactoside symporter (TC 2.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3486"/>
    <dbReference type="EnsemblBacteria" id="CCC80454">
        <property type="protein sequence ID" value="CCC80454"/>
        <property type="gene ID" value="lp_3486"/>
    </dbReference>
    <dbReference type="GeneID" id="57026700"/>
    <dbReference type="KEGG" id="lpl:lp_3486"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2902"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_1_0_9"/>
    <dbReference type="OMA" id="DIPYWSM"/>
    <dbReference type="PhylomeDB" id="F9UUF2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2942-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018043">
        <property type="entry name" value="Na/Gal_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00872">
        <property type="entry name" value="NA_GALACTOSIDE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="14">
        <location>
            <begin position="513"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC80454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="652" mass="71052" checksum="E3F9760FF444FE12" modified="2011-12-14" version="1">MDAETKQSKGRKITSRLAYSFGAFGHDAFYATLSTYFIMFVTSHLFDKSSGAQGTQMIAWITMIIAGLRFVELAIDPLIGNAIDNTNSRWGHFKPWIVIGGIIGSVVLALLFTSLGGLNTSNPILYLIIFAILYITMDIFYSFKDVGFWSMIPAISFDSAEREKTATYARVGSNIGANIVGVIVMPIVLMFSVKSNSGQGDNRGWMAFGIIIAAIALISALVVALGTKENDSELRKNTEKTSFKEVFKVLARNDQLMWLSLMYGIYTAGIAITNSLELYYFTYILGDASKFTLLGSLNAIIGIFAVLAFPPLAKKFSRRKVFFLAVVIMMISLIMFAFAGQSLPMILTAAVLFYIPQPLIFLVVLMVLSDSVEYGQLKFGHRDESLTLSVRPLLDKLGGAISNGVVGLTAVWAGMTAGATAGDVTSHGAAIFKLMMFGVPAAMILIGTFIFFKKVKLDEKMHAQIVDELEKTWSTHLETDETPAEVEAEADAKTTVYQDPVAGELISLKDVADESFANGSMGKGFAIKPTDGRVVAPFDGEVVATFPTRHAIGLRSDTGILTLIHIGIGTVKMRGTGFVQYVEKGDHVTQGQELIEFWQPAIEKAGLDDTVMVVITNYKDMPEFTYLKDSGTTVQDDEDVLQLSNVGLPDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG0</accession>
    <name>Q6LWG0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative positive regulator of cadmium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cadC</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003678450.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133731.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723567"/>
    <dbReference type="EnsemblBacteria" id="CAG17848">
        <property type="protein sequence ID" value="CAG17848"/>
        <property type="gene ID" value="CAG17848"/>
    </dbReference>
    <dbReference type="GeneID" id="57295604"/>
    <dbReference type="KEGG" id="lpl:CAG17848"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3095"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_4_9"/>
    <dbReference type="OMA" id="YRIVDPC"/>
    <dbReference type="PhylomeDB" id="Q6LWG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3148-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13478" checksum="53C250BAF2918A4B" modified="2004-07-05" version="1">MIQVDCCPGKPDLADRALLNENQAADIALLFKVLANNTRLRILHCLTREPDMAVSEIATSLNMKVQAISNQLQRLVDQKIVKAKRNGNFIEYQIIDECTAILLERAWCLAEDAGKINAGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWI0</accession>
    <name>Q6LWI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repB</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS102</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gram-positive plasmids replication protein type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377165">
        <property type="protein sequence ID" value="CAG17828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222008.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133712.1">
        <property type="nucleotide sequence ID" value="NC_006376.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723546"/>
    <dbReference type="EnsemblBacteria" id="CAG17828">
        <property type="protein sequence ID" value="CAG17828"/>
        <property type="gene ID" value="CAG17828"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17828"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3084"/>
    <dbReference type="eggNOG" id="ENOG5033XIG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098589_0_0_9"/>
    <dbReference type="OMA" id="HYHVIYI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3129-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS102"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005727">
        <property type="term" value="C:extrachromosomal circular DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002631">
        <property type="entry name" value="Plasmid_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041919">
        <property type="entry name" value="Plasmid_rep_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01719">
        <property type="entry name" value="Rep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="25289" checksum="9FA7920087368F48" modified="2004-07-05" version="1">MAKEKARYFTFLLYPESIPQDWQTKLETLGVPIAISPLHDKDLSSVEGQKYKKAHYHVIYISKNPVTAESVRLKIKRALGDKSVAKVQIVVQSMENMYLYLTHESKDAIAKNKHKYSKHDIAVLNNFDIDRYITLDVEDKDDMLNDVCDLIDDHNLANMRELRRFLKAHGSEYGMPGIKVVNSVLRAHTGLIRLYFDAVYQERKYGRGDINKETGEIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWI3</accession>
    <name>Q6LWI3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">repA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS101</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gram-positive plasmids replication protein type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377164">
        <property type="protein sequence ID" value="CAG17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222005.1">
        <property type="nucleotide sequence ID" value="NC_006375.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133708.1">
        <property type="nucleotide sequence ID" value="NC_006375.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723542"/>
    <dbReference type="EnsemblBacteria" id="CAG17825">
        <property type="protein sequence ID" value="CAG17825"/>
        <property type="gene ID" value="CAG17825"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17825"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3083"/>
    <dbReference type="eggNOG" id="COG5655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056002_0_1_9"/>
    <dbReference type="OMA" id="WFLELTR"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS101"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000989">
        <property type="entry name" value="Rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01446">
        <property type="entry name" value="Rep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="37458" checksum="A87480632724CE40" modified="2004-07-05" version="1">MADRKVLVDRSQSGKVRPWREHKLENLQYGDYLQMLHYKKSHRVKECGEVLRFVEDKNGHKKLAQTWFCHSRLCPLCNWRRSMKQSNQLTQILTEAVKQRKTGRFLFLTLTVKNTTGDLLKSELRQMGRAIAKIFQYKKVAKNLLGYVRSTEVTINHEADQPMYHHHMHVLLFMKSSYFTGTDNYISQAEWTGYWQRAMKLDYVPVVNVEAVKPNVKRQKNSLLASAQETAKYQVKSKDILTNNQEQDLQVIDDLEQALAGSRQISYGGLLKEIRKQLQLEDVENGDLINTDSDDQKVDQVVREIVAKWDYQRKNYFVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S33</accession>
    <accession>F9ULG5</accession>
    <name>Y3613_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein lp_3613</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_3613</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102253.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S33"/>
    <dbReference type="SMR" id="Q88S33"/>
    <dbReference type="STRING" id="220668.lp_3613"/>
    <dbReference type="EnsemblBacteria" id="CCC80572">
        <property type="protein sequence ID" value="CCC80572"/>
        <property type="gene ID" value="lp_3613"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3613"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3015"/>
    <dbReference type="eggNOG" id="COG4702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101036_2_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3059-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000208918" description="UPF0303 protein lp_3613">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <sequence length="155" mass="17510" checksum="E573DEEEFE686406" modified="2003-06-01" version="1">MMIDQNKIIGQEKNALLTHFNLDDVDKLVISLKKIGRENFDKVCILIKINKRIVFFHAGTQTTNENNLWIHKKANVVDKFDHSSLFEKAIYEENPDKFYINNGLSRRDYAIVGGGFPIGLESTGIIGSLIVSGLTDTEDHDLAYQALIDIQSQQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S37</accession>
    <accession>F9ULG1</accession>
    <name>IOLE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inosose dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-keto-myo-inositol dehydratase</fullName>
            <shortName evidence="1">2KMI dehydratase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolE</name>
        <name type="ordered locus">lp_3607</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O</text>
            <dbReference type="Rhea" id="RHEA:14065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:28446"/>
            <dbReference type="EC" id="4.2.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IolE/MocC family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.44" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3CNY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B=1-300"/>
    </dbReference>
    <dbReference type="PDBsum" id="3CNY"/>
    <dbReference type="AlphaFoldDB" id="Q88S37"/>
    <dbReference type="SMR" id="Q88S37"/>
    <dbReference type="STRING" id="220668.lp_3607"/>
    <dbReference type="PRIDE" id="Q88S37"/>
    <dbReference type="EnsemblBacteria" id="CCC80568">
        <property type="protein sequence ID" value="CCC80568"/>
        <property type="gene ID" value="lp_3607"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3607"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3011"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_0_0_9"/>
    <dbReference type="OMA" id="YDSRPEL"/>
    <dbReference type="PhylomeDB" id="Q88S37"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3055-MON"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00144"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q88S37"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050114">
        <property type="term" value="F:myo-inosose-2 dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01672">
        <property type="entry name" value="IolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023952">
        <property type="entry name" value="IolE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030823">
        <property type="entry name" value="IolE/MocC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04379">
        <property type="entry name" value="myo_inos_iolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000352374" description="Inosose dehydratase">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="169"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="234"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="254"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01672"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="3CNY"/>
        </source>
    </evidence>
    <sequence length="300" mass="33881" checksum="870B9B88384D024D" modified="2003-06-01" version="1">MSSKAEKDIKWGIAPIGWRNDDIPSIGKDNNLQQLLSDIVVAGFQGTEVGGFFPGPEKLNYELKLRNLEIAGQWFSSYIIRDGIEKASEAFEKHCQYLKAINAPVAVVSEQTYTIQRSDTANIFKDKPYFTDKEWDEVCKGLNHYGEIAAKYGLKVAYHHHMGTGIQTKEETDRLMANTDPKLVGLLYDTGHIAVSDGDYMALLNAHIDRVVHVHFKDVRRSKEEECRAKGLTFQGSFLNGMFTVPGDGDLDFKPVYDKLIANNYKGWIVVEAEQDPSKANPLEMAQIAHRYIKQHLIEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ST4</accession>
    <accession>F9UTI5</accession>
    <name>GCH1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP cyclohydrolase I</fullName>
            <shortName evidence="2">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folE</name>
        <name type="ordered locus">lp_3297</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Toroid-shaped homodecamer, composed of two pentamers of five dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890817.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ST4"/>
    <dbReference type="SMR" id="Q88ST4"/>
    <dbReference type="STRING" id="220668.lp_3297"/>
    <dbReference type="EnsemblBacteria" id="CCC80303">
        <property type="protein sequence ID" value="CCC80303"/>
        <property type="gene ID" value="lp_3297"/>
    </dbReference>
    <dbReference type="GeneID" id="57026565"/>
    <dbReference type="GeneID" id="66450831"/>
    <dbReference type="KEGG" id="lpl:lp_3297"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2753"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_2_9"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="PhylomeDB" id="Q88ST4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2791-MON"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000119415" description="GTP cyclohydrolase 1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <sequence length="189" mass="21461" checksum="B83186FD37BD443C" modified="2003-06-01" version="1">MIDEKNQAKIEHAVREILSAVGEDPDRPGLVETPARVARMYAEVFATKTAAPFDNYKLFKVEHPTEMVLLKDIPFYSMCEHHLLPFFGTVQVAYVPQHEQVIGLSKIPRLIDYCSQQPNVQERLTVSIATELQRILDPAGIAVSITARHMCMEMRGVSKPGVHTESSYYSGQFKTDLDLKREFLQRIAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U29</accession>
    <accession>F9URJ6</accession>
    <name>PUR9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">IMP cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name type="ordered locus">lp_2720</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="1"/>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890349.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U29"/>
    <dbReference type="SMR" id="Q88U29"/>
    <dbReference type="STRING" id="220668.lp_2720"/>
    <dbReference type="EnsemblBacteria" id="CCC79835">
        <property type="protein sequence ID" value="CCC79835"/>
        <property type="gene ID" value="lp_2720"/>
    </dbReference>
    <dbReference type="GeneID" id="57026095"/>
    <dbReference type="KEGG" id="lpl:lp_2720"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2275"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_9"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="PhylomeDB" id="Q88U29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2326-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000192097" description="Bifunctional purine biosynthesis protein PurH">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="510" mass="55306" checksum="6054866F95DD0CBA" modified="2003-06-20" version="1">MTKRALLSVSDKQGLTDFAKGLVALDYELISTGGTKKALEAADIPVIGIEEVTGFPEMLDGRVKTLHPKVHAGLLARRDLPAHMAQLKAAGIQPIDMVVVNLYPFKATIQQPDVTQAEAIEQIDIGGPSMLRSAAKNFAAVLPIVDPADYEQILADLQTDAVTPALRQRLAAKVFQHTAAYDALIAQYLTTEEFPEKLTLTYDKKQALRYGENSHQKAAFYENALPTHFSITGAKQIHGKELSYNNIKDADAALRMVSEYQQPAVVAMKHMNPCGVGLGTTIEAAWDKAYEADSISIFGGIIALNRPVDLATAEKMHALFLEIIIAPSFDDDAFAILAKKKNLRLMTVDFEQTHTADKFETISVGGGLLRQEVDAAFETPADFTVVTVTQPTPAQLKALAFGQQVVKHVKSNAVVVTTADRTLGIGSGQMNRIDSTKIAIGKAMKQAGYENAILASDAFFPMDDCVEYAAQHGIRAIVQPGGSIRDKDSIAMADRYGIAMVTTGVRHFRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U40</accession>
    <accession>F9URH7</accession>
    <name>ADDB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase/deoxyribonuclease subunit B</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent helicase/nuclease RexB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rexB</name>
        <name type="ordered locus">lp_2694</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -&gt; 3' nuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of AddA and RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. AddB/RexB type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U40"/>
    <dbReference type="SMR" id="Q88U40"/>
    <dbReference type="STRING" id="220668.lp_2694"/>
    <dbReference type="PRIDE" id="Q88U40"/>
    <dbReference type="EnsemblBacteria" id="CCC79816">
        <property type="protein sequence ID" value="CCC79816"/>
        <property type="gene ID" value="lp_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2694"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2255"/>
    <dbReference type="eggNOG" id="COG3857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007838_0_0_9"/>
    <dbReference type="PhylomeDB" id="Q88U40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2307-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01453">
        <property type="entry name" value="AddB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014141">
        <property type="entry name" value="DNA_helicase_suRexB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000379375" description="ATP-dependent helicase/deoxyribonuclease subunit B">
        <location>
            <begin position="1"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01453"/>
        </source>
    </evidence>
    <sequence length="1200" mass="136246" checksum="66DEE2EE16E64461" modified="2011-11-16" version="2">MSLQFVLGPAKMDHRRTMVAQLVATLMAKPQDQFFYLVPNHIKFDTEVDVLNRLAQAFGQPDLYAQTQVQVFSFTRLAWYLMKNEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANAQAGDLQAKLHDLAIVYKDFVAATADKYLKPADILVQLNAYLRRQDLHGTHVYVELAGFAQLPAQEQGIVTTMLEQGADVTISLMLDHKVVDRAPENGTLFYQSGRLYYRLYQYARIRQIPVSQDIYAETPRVAPGLVALDDFWRGQPQAATGYEEPNTNVHLFRTDSRQTELAQVGRMIRAMVAKKHADPADDYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELINALFDIDAQQYQYRDVMRVLKTELLMPNINGQPMDRQAYRQAVDLTENFILKSGYHGQRWVQREDWQYFQLTEGDAGVETDQNAEISRQINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRDQALDRQDVRAAAEPEQTWQTFCGMLDEYVTILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNLLSDVDKENLQLTLSSLDGDHYLNDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFNLREHTYLGTPDPTNADARPFVGTKRRTISHVIQVYRDVLTTNTDRNRVGAPLQPAPVWVWLRQQLTRDPQFGELARQLMAGLSYRNQPVKLTPASVEALYGHQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIPLAQASDQQLGQYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEILFGNVGKEHGLKALDFQIDATHSVHVRGKIDRLDQIQVADQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNEQALVGSDQAAVKLAGALYMHIQNPTLKPKDIQGGFEAALLKKNKYKGILLDDPQLLEHLDSELQQGNGTSKVYPFARKKDGSYSGGRAASLVTNDQLERLLQHNSQLIIAAAEAIFAGEIQLNPIRLNDKTTALQYSPYLSIMQFDAMLAENAYRDLPPLSAKQVLDLLKTQKGGENHE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UT1</accession>
    <accession>F9UQS6</accession>
    <name>KITH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine kinase</fullName>
            <ecNumber evidence="1">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdk</name>
        <name type="ordered locus">lp_2379</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UT1"/>
    <dbReference type="SMR" id="Q88UT1"/>
    <dbReference type="STRING" id="220668.lp_2379"/>
    <dbReference type="EnsemblBacteria" id="CCC79565">
        <property type="protein sequence ID" value="CCC79565"/>
        <property type="gene ID" value="lp_2379"/>
    </dbReference>
    <dbReference type="GeneID" id="57025909"/>
    <dbReference type="GeneID" id="66450122"/>
    <dbReference type="KEGG" id="lpl:lp_2379"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2011"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_2_2_9"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="PhylomeDB" id="Q88UT1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2050-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000174984" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <sequence length="192" mass="22147" checksum="FB4E51939625CEBC" modified="2003-06-01" version="1">MAQLFFRYGAMNSGKTIEILKVAHNYEEQDKSVIILTSGLDNRDGVGYVASRIGLKREATPVFDDTNIFEIVKQTNPDAACVLIDEAQFLKKHHVLELADIVDELKIPVMTFGLKNDFRNELFEGSKYLLLYADKIEEMKTICWFCRKKAIMNLRFHDGQPVYEGEQVQIGGNEAYYPVCRHHYFYPPKLTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UZ3</accession>
    <accession>F9UQL3</accession>
    <name>CINA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative competence-damage inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cinA</name>
        <name type="ordered locus">lp_2302</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890016.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UZ3"/>
    <dbReference type="SMR" id="Q88UZ3"/>
    <dbReference type="STRING" id="220668.lp_2302"/>
    <dbReference type="EnsemblBacteria" id="CCC79502">
        <property type="protein sequence ID" value="CCC79502"/>
        <property type="gene ID" value="lp_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2302"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1946"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_9"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="PhylomeDB" id="Q88UZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1986-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000156763" description="Putative competence-damage inducible protein">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <sequence length="420" mass="45076" checksum="9A4E850C6D58A2A1" modified="2003-06-01" version="1">MQAEIIAVGTEILLGQITNTNSTYIARGLAELGIDSYYQTVVGDNRQRLSTVIEIAAQRNDLVILTGGLGPTKDDLTKQTLAHYLNVALVEDQAAMQKITAWFATNDKVMTANNRLQALYPAGAQPLTNHNGMAVGAFYQSENSADFLLLPGPPRELAVMFDSEAKPKLAAAYGEQAQIYSRVMRFYGISESELATRLQPLIDEQQAVTIAPYAKTNEVTLRLSAQAMTETAARGMIDKVDHQIKATVGPYFYGYGDDNSLVTTVINQMIAAKLSITAAESLTAGLFQSTIGSVSGVSAIFPGGFVTYANEAKHQLVNVPQAIIDAEGVVSEATAKAMASGAKQQLNTDVGISFTGVAGPGTLGGQPAGTVWIGLAYRDRPVKAKQYHFAGNRQQIRERSVMAGLDLLRHALNEDTDLKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VB0</accession>
    <accession>F9UQ96</accession>
    <name>RPOY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit epsilon</fullName>
            <shortName evidence="1">RNAP epsilon subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoY</name>
        <name type="ordered locus">lp_2157</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A non-essential component of RNA polymerase (RNAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit epsilon family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640827.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889899.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VB0"/>
    <dbReference type="SMR" id="Q88VB0"/>
    <dbReference type="STRING" id="220668.lp_2157"/>
    <dbReference type="EnsemblBacteria" id="CCC79385">
        <property type="protein sequence ID" value="CCC79385"/>
        <property type="gene ID" value="lp_2157"/>
    </dbReference>
    <dbReference type="GeneID" id="57025691"/>
    <dbReference type="GeneID" id="66449920"/>
    <dbReference type="KEGG" id="lpl:lp_2157"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1826"/>
    <dbReference type="eggNOG" id="COG5503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187518_0_0_9"/>
    <dbReference type="OMA" id="TIYVEGE"/>
    <dbReference type="PhylomeDB" id="Q88VB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1846-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01553">
        <property type="entry name" value="RNApol_bact_RpoY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009907">
        <property type="entry name" value="RpoY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07288">
        <property type="entry name" value="RpoY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000163127" description="DNA-directed RNA polymerase subunit epsilon">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01553"/>
        </source>
    </evidence>
    <sequence length="72" mass="8719" checksum="BA3535ACD5A55FB2" modified="2003-06-01" version="1">MIYKVYYQETKERNPQRETTQSLYLEAETEVAARTLVEDNTDHNIEFIEPLEGNFLDYEQKNPEYHLTEFNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VI8</accession>
    <accession>F9UQ16</accession>
    <name>Y2061_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0154 protein lp_2061</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2061</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0154 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889819.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VI8"/>
    <dbReference type="SMR" id="Q88VI8"/>
    <dbReference type="STRING" id="220668.lp_2061"/>
    <dbReference type="EnsemblBacteria" id="CCC79305">
        <property type="protein sequence ID" value="CCC79305"/>
        <property type="gene ID" value="lp_2061"/>
    </dbReference>
    <dbReference type="GeneID" id="57025611"/>
    <dbReference type="GeneID" id="66449838"/>
    <dbReference type="KEGG" id="lpl:lp_2061"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1746"/>
    <dbReference type="eggNOG" id="COG3763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180108_0_1_9"/>
    <dbReference type="OMA" id="PISEEMM"/>
    <dbReference type="PhylomeDB" id="Q88VI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1766-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00363">
        <property type="entry name" value="UPF0154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005359">
        <property type="entry name" value="UPF0154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03672">
        <property type="entry name" value="UPF0154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000214963" description="UPF0154 protein lp_2061">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00363"/>
        </source>
    </evidence>
    <sequence length="78" mass="8814" checksum="D609FADACD0B2BCC" modified="2003-06-01" version="1">MTVSTGIWILIVVIGVLVGLTGGFFGARHYMQNYLKQNPPISEEMLRSMMMQMGQRPSEKKLHQMLNSMKAASKNDNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-19" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ7</accession>
    <accession>F9UQ07</accession>
    <name>RRF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">lp_2052</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889810.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ7"/>
    <dbReference type="SMR" id="Q88VJ7"/>
    <dbReference type="STRING" id="220668.lp_2052"/>
    <dbReference type="EnsemblBacteria" id="CCC79296">
        <property type="protein sequence ID" value="CCC79296"/>
        <property type="gene ID" value="lp_2052"/>
    </dbReference>
    <dbReference type="GeneID" id="66449829"/>
    <dbReference type="KEGG" id="lpl:lp_2052"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1737"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_9"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="PhylomeDB" id="Q88VJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1757-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167476" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="187" mass="20594" checksum="6ED4C3F3B01AB96A" modified="2003-06-01" version="1">MAITEPILKEAQERMKKAEAALQRELGNIRAGRANASLLNRISADYYGAQTPLNQMAAITVPEPRVLMVTPFDKSALKEIEKAILASDLGISPANDGSAIRLVIPQLTEERRKELAKDVKAEGERAKVAVRNVRRDAMEALKKGHKDGQFTDDQLHQLEDQAQKLTDQAGKDVDAIVADKEKEILEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X05</accession>
    <accession>F9UNJ3</accession>
    <name>PRSA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Foldase protein PrsA 1</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prsA1</name>
        <name type="synonym">prtM1</name>
        <name type="ordered locus">lp_1452</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PrsA family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889296.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X05"/>
    <dbReference type="SMR" id="Q88X05"/>
    <dbReference type="STRING" id="220668.lp_1452"/>
    <dbReference type="EnsemblBacteria" id="CCC78782">
        <property type="protein sequence ID" value="CCC78782"/>
        <property type="gene ID" value="lp_1452"/>
    </dbReference>
    <dbReference type="GeneID" id="57025083"/>
    <dbReference type="KEGG" id="lpl:lp_1452"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1215"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_6_1_9"/>
    <dbReference type="OMA" id="SEFGPGM"/>
    <dbReference type="PhylomeDB" id="Q88X05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1243-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01145">
        <property type="entry name" value="Foldase_PrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023059">
        <property type="entry name" value="Foldase_PrsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000029307" description="Foldase protein PrsA 1">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="298" mass="32619" checksum="342E76C1B8997326" modified="2003-06-01" version="1" precursor="true">MKKWLIALAGVLLTFTLAGCGSKTVASTSGGKITESQYYSSMKGTSSGKQVLQQMILNKVLEKDYGSKVSTKQVTKQYNTYKSQYGSSFSTVLSQNGLTTKTFKEQLRSNLLLKEAVKDKVKITDKALKKQWKSYEPKVTVQHILVAKSATADKVLDALKKDSSQANFTKLAKKYSTDTTTKNDGGKLSAFDNTNTSYSSKFLTAAFKLKNGEYTTSAVKTSNGYEIIRMIKNPGKGKMSDHTADLKKQIWDNDMSDSTVLQNVVSKVLKGGNVSIKDNDLKDILSSYLSTSSSSSSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-12-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XF3</accession>
    <accession>F9UN45</accession>
    <name>RF3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 3</fullName>
            <shortName evidence="1">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfC</name>
        <name type="ordered locus">lp_1255</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XF3"/>
    <dbReference type="SMR" id="Q88XF3"/>
    <dbReference type="STRING" id="220668.lp_1255"/>
    <dbReference type="PRIDE" id="Q88XF3"/>
    <dbReference type="EnsemblBacteria" id="CCC78634">
        <property type="protein sequence ID" value="CCC78634"/>
        <property type="gene ID" value="lp_1255"/>
    </dbReference>
    <dbReference type="GeneID" id="66449131"/>
    <dbReference type="KEGG" id="lpl:lp_1255"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1064"/>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_9"/>
    <dbReference type="PhylomeDB" id="Q88XF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1075-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000210946" description="Peptide chain release factor 3">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="11"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <sequence length="525" mass="59562" checksum="D6C4D7FD8EB33418" modified="2011-11-16" version="2">MNKTELTAAVNTRRTFAIISHPDAGKTTITEQMLLFGGVVRQAGTVKARKSGNFAKSDWMEIEKKRGISVTSSVMQFDYDGKRINILDTPGHEDFSEDTYRTLMAVDSAVMVIDSAKGIEPQTKKLFQICKMRGIPIFTFMNKLDRDGREPLDLLNEVEEVLGIETYPMNWPMGMGKGLKGLYDRYNHRVELYHNEAHGETFLPLDENGELDPSNELTKDSIYRDTLDEVELINEAGNDFDEAKVMAGDMTPVFFGSALTNFGVETFLKTYLQYAPKPAAHKTRDDQVVQPTDDEFAGFVFKIQANMNPNHRDRIAFVRICSGEFDRGMDVVLQRTGKKMRLNNSTQFMADTRETVETAVAGDIVGLYDTGNFQIGDTIYAGKNAVQFEKLPQFTPELFMRVTAKNVMKQKSFHKGIEQLVQEGAVQLYTSYSTGDYILGAVGQLQFEVFKFRMQNEYNSEVVMEPMGSKTARWIDPEQLDEKMSSSRNLLVKDRYGAPLFLFENAFAERWFADKYPDVKLTSKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW1</accession>
    <accession>F9UMN0</accession>
    <name>RS11_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">lp_1061</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888983.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW1"/>
    <dbReference type="SMR" id="Q88XW1"/>
    <dbReference type="STRING" id="220668.lp_1061"/>
    <dbReference type="EnsemblBacteria" id="CCC78469">
        <property type="protein sequence ID" value="CCC78469"/>
        <property type="gene ID" value="lp_1061"/>
    </dbReference>
    <dbReference type="GeneID" id="57024716"/>
    <dbReference type="GeneID" id="66448972"/>
    <dbReference type="KEGG" id="lpl:lp_1061"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.896"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_9"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="PhylomeDB" id="Q88XW1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-912-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000123162" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="129" mass="13778" checksum="3662CCC711F359B3" modified="2003-06-20" version="1">MATRKTTRRRRVKKNIESGVAHIHSTFNNTLVMITDMQGNAIAWSSAGSLGFKGSRKSTPFAAQMAAEAAAKASMEHGMKTVEVAVKGPGSGREAAIRALQATGLEVSAIRDVTPVPHNGSRPPKRRRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX3</accession>
    <accession>F9UML8</accession>
    <name>RS14Z_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">lp_1048</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888971.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX3"/>
    <dbReference type="SMR" id="Q88XX3"/>
    <dbReference type="STRING" id="220668.lp_1048"/>
    <dbReference type="EnsemblBacteria" id="CCC78457">
        <property type="protein sequence ID" value="CCC78457"/>
        <property type="gene ID" value="lp_1048"/>
    </dbReference>
    <dbReference type="GeneID" id="49393330"/>
    <dbReference type="GeneID" id="57024704"/>
    <dbReference type="GeneID" id="66448960"/>
    <dbReference type="KEGG" id="lpl:lp_1048"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.884"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_9"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="PhylomeDB" id="Q88XX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-900-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000269108" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7161" checksum="DE3B80CAF66DEE76" modified="2003-06-01" version="1">MAKKSQIAKQKRGAKFNVQNYTRCERCGRPHSVYRKFHLCRICLRDLAHKGQIPGMKKASW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-28" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YX0</accession>
    <accession>F9UL84</accession>
    <name>RL11_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">lp_0619</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YX0"/>
    <dbReference type="SMR" id="Q88YX0"/>
    <dbReference type="STRING" id="220668.lp_0619"/>
    <dbReference type="EnsemblBacteria" id="CCC78099">
        <property type="protein sequence ID" value="CCC78099"/>
        <property type="gene ID" value="lp_0619"/>
    </dbReference>
    <dbReference type="GeneID" id="57024394"/>
    <dbReference type="KEGG" id="lpl:lp_0619"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.519"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_9"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="PhylomeDB" id="Q88YX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-530-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104301" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="141" mass="14760" checksum="42E708A1704A6A95" modified="2003-06-01" version="1">MAKKVANVVKLQIPAGKATPAPPVGPALGQAGINIMGFTKDFNARTADQAGMIIPVVITVYEDRSFDFITKTPPAAVLLKKAAGVESGSGEPNTKKVATVTKDQVKQIAETKMQDLNAADVEAAMRMIEGTARSMGFTVEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z08</accession>
    <accession>F9UL43</accession>
    <name>KHSE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine kinase</fullName>
            <shortName evidence="1">HK</shortName>
            <shortName evidence="1">HSK</shortName>
            <ecNumber evidence="1">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrB</name>
        <name type="ordered locus">lp_0572</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888572.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z08"/>
    <dbReference type="SMR" id="Q88Z08"/>
    <dbReference type="STRING" id="220668.lp_0572"/>
    <dbReference type="EnsemblBacteria" id="CCC78058">
        <property type="protein sequence ID" value="CCC78058"/>
        <property type="gene ID" value="lp_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0572"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.476"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_0_9"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="PhylomeDB" id="Q88Z08"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-488-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156580" description="Homoserine kinase">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <sequence length="291" mass="30701" checksum="5B5D4108D76734C6" modified="2003-06-01" version="1">MLTISVPATSANLGPGFDSIGLALDMQLTLQVLQPSDHWQIDHPFGADVPTDERNLIIKTALHLVPDLQPQHLQMASKIPLARGLGSSSTAIVAGLVLANELTGATRSSAELLEVATQLEGHPDNVAPALLGGLVVATNTDGRVRAVKLPLPMLFASVYVPNEPLLTTASRQALPTELAYHQAVTGSSVANTLVAALATQNWDVALPLLEQDQFHEQYRAKLVPALQTVRDHAHALGLTGTYLSGAGPTVITLGDYGQLATLQAQLSQDTTLTGQLFLLPMDATGVKVQKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZS9</accession>
    <accession>F9UT27</accession>
    <name>GREA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription elongation factor GreA 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transcript cleavage factor GreA 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">greA1</name>
        <name type="ordered locus">lp_0223</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100924.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZS9"/>
    <dbReference type="SMR" id="Q88ZS9"/>
    <dbReference type="STRING" id="220668.lp_0223"/>
    <dbReference type="EnsemblBacteria" id="CCC77758">
        <property type="protein sequence ID" value="CCC77758"/>
        <property type="gene ID" value="lp_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0223"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.185"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_9"/>
    <dbReference type="OMA" id="DQIFFGA"/>
    <dbReference type="PhylomeDB" id="Q88ZS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-180-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176934" description="Transcription elongation factor GreA 1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <sequence length="156" mass="17513" checksum="44B99972FAF5855A" modified="2003-06-01" version="1">MEPTFNKMTAAGYHAIEQEIEDLKQQRPERIRILAAAAALGDRSENAEYSSAKRDLGRLESRLRYLNKQLQYAQIVQPADNDQLDIGKFVTIEFLDDHDQITYQLVGKQEANLEQQKISFTSPIGQALANHTVDDVVTVNAPNGAYQVKVIAVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL54</accession>
    <name>F9UL54_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0584"/>
    <dbReference type="EnsemblBacteria" id="CCC78069">
        <property type="protein sequence ID" value="CCC78069"/>
        <property type="gene ID" value="lp_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0584"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.487"/>
    <dbReference type="eggNOG" id="ENOG502ZBIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051151_2_1_9"/>
    <dbReference type="OMA" id="LELPIMQ"/>
    <dbReference type="PhylomeDB" id="F9UL54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-500-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="177"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="413" mass="45774" checksum="F6AAB68D57270093" modified="2011-10-19" version="1">MQEYMCNRGYQTLINVAVLSGIGDGLYNIVFVIYAGSLSFSTLAVSLASMATLVPSLLSMLTGYFADQSRHKVRAILVTRNLQFVLFLILAFLITLPRNIWLFFLLLSINIVSDTLGTYGNGLALPLLRHLLPENKLKQSMGFMVAMTLMAQVVFQGIGSVIIVMLHHNYMVVGLINALTFLLSALLVKYRFGVLCVAEPQMVERKQVSMIRSLGLTLRYLYRNNFLFSVIILTFFINVFGASMSGLINVTLLSVKTMWLVNYGISVAIMNMMISIGMITGSLVTNGIVRKLPLMYLFAISLSFSGLCGISFIWHESAYLSIVLLFVMGYFIGKINPRISAIVLQSIPEKRLAAVDGLLNMVSMLGAPVGQLLFLGIANVVGIAYSWFAFSIGCFFLIVIIVLKFIKMDEPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL68</accession>
    <name>F9UL68_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pepC1</name>
        <name evidence="4" type="ordered locus">lp_0601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78083">
        <property type="protein sequence ID" value="CCC78083"/>
        <property type="gene ID" value="lp_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0601"/>
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    <dbReference type="eggNOG" id="COG3579">
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    <dbReference type="OMA" id="WDMIVNL"/>
    <dbReference type="PhylomeDB" id="F9UL68"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    </dbReference>
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        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="443" mass="50248" checksum="6472BB506A5F8057" modified="2011-10-19" version="1">MSKAISMNQIANFQADLDQRPEAKVIERSVTKNGILASSQDIQAMSQTTPVFSIDLDTGDVANQKQSGRCWMFAALNTMRHSLAEKFNLKHFELSQNYTFFWDKFEKANYFYENVLATADQATSSRKVAWLMTTPQQDGGQWDMLVAIIQKYGIVPKSVMPETYNSSKSAEINSTLNLKLRKDAVELRELVAAGTSDDAIQERKEKMLNEVYRMLAYAFGEPVSHFDWEYRDDKKQYHIDQNLTPQSFFEKYVGWNLDDYVSIINAPTDDKPYNHTYTIEMLGNVLGGREVKHLNVSMADFKQLAIKQLQAGQSVWFGCDVGQSSDRQKGVMATDVYSKDELFDVDLSMSKAERLDYGESLMTHAMVITGVDLVDGQPTKWKVENSWGDKVGTKGFFVMSDAWMDEYCYQVVVNKEFLSDDLKAAQAEEPTVLAPWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN0</accession>
    <name>F9ULN0_LACPL</name>
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    </protein>
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        <name evidence="7" type="ORF">lp_3688a</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891151.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3688a"/>
    <dbReference type="EnsemblBacteria" id="CCC80637">
        <property type="protein sequence ID" value="CCC80637"/>
        <property type="gene ID" value="lp_3688a"/>
    </dbReference>
    <dbReference type="GeneID" id="49395612"/>
    <dbReference type="GeneID" id="57026863"/>
    <dbReference type="GeneID" id="66448157"/>
    <dbReference type="KEGG" id="lpl:lp_3688a"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9ULN0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3124-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="44" mass="5404" checksum="90FCCEAA3EAEDD4B" modified="2011-10-19" version="1">MKRTYQPKKRHRQRVHGFRKRMSTSNGRKVLARRRQRGRKVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR7</accession>
    <name>F9ULR7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101129.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888670.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0679"/>
    <dbReference type="EnsemblBacteria" id="CCC78156">
        <property type="protein sequence ID" value="CCC78156"/>
        <property type="gene ID" value="lp_0679"/>
    </dbReference>
    <dbReference type="GeneID" id="57025311"/>
    <dbReference type="KEGG" id="lpl:lp_0679"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.571"/>
    <dbReference type="HOGENOM" id="CLU_2219797_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-590-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021358">
        <property type="entry name" value="DUF2977"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11192">
        <property type="entry name" value="DUF2977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11658" checksum="54AFB5643AFD5B49" modified="2011-10-19" version="1">MQVKLDETKHVVSYALVGGLEDAIDYDESQLPADFLTATDSSAYWLIDGVLTKDPNYAPSIQPVVEDQPSNEQQSLTKLAQQVTEQQEHIASLEESLTQLVKGGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULU8</accession>
    <name>F9ULU8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonates ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnE2</name>
        <name evidence="7" type="ordered locus">lp_0713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888701.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0713"/>
    <dbReference type="EnsemblBacteria" id="CCC78187">
        <property type="protein sequence ID" value="CCC78187"/>
        <property type="gene ID" value="lp_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0713"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.600"/>
    <dbReference type="eggNOG" id="COG3639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064254_1_2_9"/>
    <dbReference type="OMA" id="NAGHFFD"/>
    <dbReference type="PhylomeDB" id="F9ULU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-622-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="262" mass="29425" checksum="B58C3160DBC57C5B" modified="2011-10-19" version="1">MTPQRFFRQRRLRLSVVLLILIGIYVLSMALVNFQAWASISKIPAGLMWLFTNFIPTSRSISYLGPILYQLWRTLLVAISSTMVASLFALIFAILGAKTTTPTPVLRWIIRFGASLLRNIPVVAWAMILLFSFKQSDFTGFLALFFMTLGYLTRAFTETIEDLDAEKLQALQAVGANYFQCVFCGVLPEAASTLTSWILYMIENNLRDATLVGLLTGTGVGFLFDYYFKAFRYDAAGLIVLLIAILVIVLELTSNRIRRAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM08</accession>
    <name>F9UM08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-directed RNA polymerase, sigma factor 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoN</name>
        <name evidence="11" type="ordered locus">lp_0787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888761.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0787"/>
    <dbReference type="EnsemblBacteria" id="CCC78247">
        <property type="protein sequence ID" value="CCC78247"/>
        <property type="gene ID" value="lp_0787"/>
    </dbReference>
    <dbReference type="GeneID" id="57024489"/>
    <dbReference type="KEGG" id="lpl:lp_0787"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.664"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_1_1_9"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="PhylomeDB" id="F9UM08"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-683-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="279"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="445" mass="51365" checksum="370E50867FDFB90A" modified="2011-10-19" version="1">MALGPGFRQQQRQSQKLAMTQRLQQSIQMLQFNVEELRDFLTQKALENPLIDVDTNWNNNHASLNAAKNVTTKADFIERVSTSNQHSLFEYLLDQIHLTMRDTHLRQIVLYLIEYVDVNGYLRIDERQVRQETKATPIELLDAITLLQQLDPPGVGARSLQEALMLQTENDDHAPNLAYIVLEESFDELVNRQWDLLAKKYQVTLADISSIYDYVRTLTPVPGAAIGQETTGYIFPDLVVTNQGGQLALRTASMAQPVVKFRSRYYQQMGQHDDQEVTEYLKEKKSEYDWIANSLQQREATIFRVGTAIIERQADFFLEKTTDLRPLLLRDVAQQLKVHESTISRSINGKYIQTDFGMFELKRFFTKAVSKRPTGGKIVSADSVQHRIVTLIEQENKEKPLSDQKIVQILNAENVELSRRTVAKYRENLNIPSSSRRKQYLRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM30</accession>
    <name>F9UM30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed DNA polymerase III, epsilon chain</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0811"/>
    <dbReference type="EnsemblBacteria" id="CCC78269">
        <property type="protein sequence ID" value="CCC78269"/>
        <property type="gene ID" value="lp_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0811"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.686"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_14_1_9"/>
    <dbReference type="PhylomeDB" id="F9UM30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-705-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="178" mass="20253" checksum="977A1302D3680C69" modified="2011-10-19" version="1">MNFVAMDFETANAKRDSACSLALTVVRNNQISDEFYTLIKPESDFFWRNVQIHGIHEADVADAPKFPDVWQHIEPFFQRDRLVIAHNAPFDIGVLRNTLAHYGISAPEYLSMDTVKTSQRFYPELPNHKLDTVCQALDIDLQHHHNALDDSLACANILLTEAQAFGTEQLKPFVRVQG</sequence>
</entry>
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        </submittedName>
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        <name evidence="3" type="ordered locus">lp_0816</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888788.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0816"/>
    <dbReference type="EnsemblBacteria" id="CCC78274">
        <property type="protein sequence ID" value="CCC78274"/>
        <property type="gene ID" value="lp_0816"/>
    </dbReference>
    <dbReference type="GeneID" id="57024515"/>
    <dbReference type="KEGG" id="lpl:lp_0816"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.691"/>
    <dbReference type="eggNOG" id="COG1846">
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    <dbReference type="HOGENOM" id="CLU_083287_9_1_9"/>
    <dbReference type="OMA" id="FEQWLIM"/>
    <dbReference type="PhylomeDB" id="F9UM35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-710-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19801" checksum="2EC86E8987311101" modified="2011-10-19" version="1">MTESEIHERFVDTYMHILKYVGDFVSVPTRPYKITFEAYTVMRMIATSEEPLTLVKIAKEQRVSRSAIARQINVLLDLKYIEQTTNTHDRRIKYLSLTPAGHKVEQEITTASEERFHQWVQVYGEKRASDTLRYINDAEQKATELGFSGFSGLHDKRGRHTEYSDPKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM46</accession>
    <name>F9UM46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101170.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888799.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0828"/>
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        <property type="protein sequence ID" value="CCC78285"/>
        <property type="gene ID" value="lp_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0828"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.703"/>
    <dbReference type="eggNOG" id="ENOG5030A1E">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1832646_0_0_9"/>
    <dbReference type="OMA" id="VITHQDQ"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="16518" checksum="AF97CAF091D2B418" modified="2011-10-19" version="1">MKNGALLQFIQSHFQTRFRFRNAFETQLTVQILSRLIGEHPESLLLTRRDVEALAGCSLDAPALQREYFPQRAMTLLETALDELVTLSVITHQDQGRTRYPLFRSVQLDQVCQRIVFNLNLDVLPQLTDWSRELQQEQERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA2</accession>
    <name>F9UMA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="CCC78341"/>
        <property type="gene ID" value="lp_0899"/>
    </dbReference>
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    <dbReference type="GeneID" id="66448845"/>
    <dbReference type="KEGG" id="lpl:lp_0899"/>
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    <dbReference type="HOGENOM" id="CLU_205796_0_0_9"/>
    <dbReference type="OMA" id="RWSALEF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-777-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7286" checksum="41F2D6382A13853F" modified="2011-10-19" version="1">MMMYPYLNLGPRDGVLIIAAAIMLALTVVFNWSVWELLFAVVAVVIAFLAGSMKPSKKNVLAFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC1</accession>
    <name>F9UMC1_LACPL</name>
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        <submittedName>
            <fullName evidence="9">Carbohydrate (Prephenate-like) transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCC78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0922"/>
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        <property type="gene ID" value="lp_0922"/>
    </dbReference>
    <dbReference type="GeneID" id="57024601"/>
    <dbReference type="KEGG" id="lpl:lp_0922"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.780"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_5_9"/>
    <dbReference type="PhylomeDB" id="F9UMC1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-796-MON"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="79"/>
        </location>
    </feature>
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            <end position="112"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="427"/>
        </location>
    </feature>
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        <location>
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            <end position="431"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="432" mass="46206" checksum="433B198A026809DA" modified="2011-10-19" version="1">MVYFYPINDSRWYTFIHLFLYCKALKLLVVPNSKGVSPIFNQITIHNQHTENWLIIGLFCGAFVTGADAFIISALLPAIATSLHVPTNTAAYGVTVYALCYAIGAPLFGPLGDRFNKRFLLISGCGIFLLGTLLCGLANSLLTFYLYRAIAGIGAALFVPNIWAFIGTYFNGQRLNQVMGIVMSALSLSIATGVPLGALLAQLSSWHMAFWGSAMLTLIALSILTIAIPSLPSQNAQPDGYFTSFKTLVHTPHAIAALLITLTWMTGFYGVYTFLGVFATATFHFNTMQTGLIFITYGSANFVASFFAGKLISLLGKKQSVTINGLVSATLVLSLGIWGQHLAVLLIILVVLALSQGWGVTALTATIVNIVPSNRSTIMSFNSAFLYYGLTLGSAAGGLLLTKIGFYAVTIAAATALLVAVLIANALSHYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMF9</accession>
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        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888912.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78398">
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        <property type="gene ID" value="lp_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="57024639"/>
    <dbReference type="KEGG" id="lpl:lp_0965"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.821"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_8_0_9"/>
    <dbReference type="OMA" id="GLQSVYF"/>
    <dbReference type="PhylomeDB" id="F9UMF9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-834-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="11818" checksum="9DD9BC2CDDF89199" modified="2011-10-19" version="1">MANFQQSETALIESATLINIFAEKIRRQIIIALGNSDNGLNVTDITALVNISRPAVSHHLRLMREAGVIDMRSNGVEHIYFLTLTAPLQQLQATFATLTADNAPLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMM5</accession>
    <name>F9UMM5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ordered locus">lp_1056</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888978.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1056"/>
    <dbReference type="EnsemblBacteria" id="CCC78464">
        <property type="protein sequence ID" value="CCC78464"/>
        <property type="gene ID" value="lp_1056"/>
    </dbReference>
    <dbReference type="GeneID" id="57024711"/>
    <dbReference type="GeneID" id="66448967"/>
    <dbReference type="KEGG" id="lpl:lp_1056"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.891"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_1_9"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="PhylomeDB" id="F9UMM5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-907-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="431" mass="47186" checksum="BE491879F769BDF4" modified="2011-10-19" version="1">MLTTMKNALKVKDIRNKLLFTLGVLIVFRLGSYITVPGVNAQALQSVASSGLISMLNTFSGGGLTNYSILAMGVSPYITAQIIVQLLQMDIVPKFVEWGKQGEVGRRKLNQATRWLTIVLAFVQSIGITAGFNSLSQLKLVNNPSISTYLTIGVILTGGAMLTTWMGDMITDRGIGNGVSIIIFAGIIARMPTSIYQIYQEQFVNVSQSDWWKSGLFVVGLALLVLIIVMFVTWVEQANDRIPIQYTRRAAGAPDSSYLPLKVNVAGVIPVIFASSFIATPQTILLGFQSSHGDETWYTVLSNIFNMQSTTGAILYTILIVLFTFFYAFVQVNPEKLSKNLQKQGSYIPGVWPGKDTQDWVSKLLMRLSTVGALYLGLISLIPLLASDIWGLDESIGLGGTSLLIVVGVALETIRQIKGLMMKRDYVGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMN7</accession>
    <name>F9UMN7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH dehydrogenase, membrane-anchored</fullName>
            <ecNumber evidence="5">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndh2</name>
        <name evidence="5" type="ordered locus">lp_1069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1069"/>
    <dbReference type="EnsemblBacteria" id="CCC78476">
        <property type="protein sequence ID" value="CCC78476"/>
        <property type="gene ID" value="lp_1069"/>
    </dbReference>
    <dbReference type="GeneID" id="57024722"/>
    <dbReference type="KEGG" id="lpl:lp_1069"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.903"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_6_0_9"/>
    <dbReference type="OMA" id="ELMGEFI"/>
    <dbReference type="PhylomeDB" id="F9UMN7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-919-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="636" mass="71909" checksum="B90A844F5E457355" modified="2011-10-19" version="1">MAKKNIVVVGAGFAGVYATKKLSKHFKKNADVEITLIDRHSYFTYMTELHEVATERVEPEHIQYDLQRLFARRKNVRLVTDTVTGIDKKAQTVTTEHGSYQYDQLLISLGGESNDFGTPGVKEHGFELWSFEQAMALRAHLSAIIRRGAAELDPAKRKAMLTFTVCGSGFTGSELIGELIEYRDVLARDNKLDPSEITLQLVEAAPTIINMLNRTQAGKAAKYMEKHGVKIMTNSMITEVCEDHVNLKGKDPIPTYTLIWTAGVRANSIVKKFGIETNPRGGRLMANEFMQAKDCNNIFLAGDSTSYQEPDQPRPVPQIVQGAEETAAKAVEGIIKNVDQTDVTIKPFKGAYQASVDSIGSKYAVAQVLEKWNVSGFIAVLLKHAINWMYYVQIFSGYYLFQYFMHEFFRTRNNRNVFRGWVSRAGNVLWSVPLRFFYGAMWLWDCWTKVQGSESWFTDKLRLPFEWITVAATSGASQATKAAATSGASEAATSTVKAAKGVFSLSYMYGKEPLMVFDKMPHWFESITKVFIPNMQMALFFQKFMTCVEIVIALCIFFGLFTWFANAVTIGLVVVFCLSGMFYWVNIWMIFVALALMNGSGRTFGLDYWVVPWMQKHLGHWWYGNVRSHYDGVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW8</accession>
    <name>F9UMW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889071.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063180"/>
    <dbReference type="EnsemblBacteria" id="CCC78557">
        <property type="protein sequence ID" value="CCC78557"/>
        <property type="gene ID" value="lp_1168"/>
    </dbReference>
    <dbReference type="GeneID" id="57024804"/>
    <dbReference type="GeneID" id="66449059"/>
    <dbReference type="KEGG" id="lpl:lp_1168"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.987"/>
    <dbReference type="eggNOG" id="ENOG5032IGN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1445975_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1000-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="21249" checksum="3B206031AF500D47" modified="2011-10-19" version="1">MFKPMASVFTNHQIAGHYRAIERAQKCVVPFHFEIQGQEYPKPKPERNWLRRLSGTSSEKYAMVELTPTKVVLWSPEGRNLGEMPLSAVRRIQIGAIRCHVTEGLDPRHAFRATIFVLTDSGNYYFANSDMEVLPAICKFAHEHQVPVEDPLRLIPLLKVGWRVAAVTLHETYAQLVAHTGYPADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN66</accession>
    <name>F9UN66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889169.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1281"/>
    <dbReference type="EnsemblBacteria" id="CCC78655">
        <property type="protein sequence ID" value="CCC78655"/>
        <property type="gene ID" value="lp_1281"/>
    </dbReference>
    <dbReference type="GeneID" id="57024896"/>
    <dbReference type="GeneID" id="66449153"/>
    <dbReference type="KEGG" id="lpl:lp_1281"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1087"/>
    <dbReference type="eggNOG" id="COG4703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157750_2_1_9"/>
    <dbReference type="OMA" id="FDNIDMI"/>
    <dbReference type="PhylomeDB" id="F9UN66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1097-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014904">
        <property type="entry name" value="YkuJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038073">
        <property type="entry name" value="YkuJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08796">
        <property type="entry name" value="DUF1797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037356">
        <property type="entry name" value="DUF1797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143567">
        <property type="entry name" value="SSF143567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="78" mass="9008" checksum="947FC5D8F814014A" modified="2011-10-19" version="1">MDKSELSAILKRLEAMRTTEATEVQSRRFEKEGVQRGQVAYDPATSTYTLQEFNPDQTFEFDNIDLVAIELYDLLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN71</accession>
    <name>F9UN71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1291"/>
    <dbReference type="DNASU" id="1062788"/>
    <dbReference type="EnsemblBacteria" id="CCC78660">
        <property type="protein sequence ID" value="CCC78660"/>
        <property type="gene ID" value="lp_1291"/>
    </dbReference>
    <dbReference type="GeneID" id="57024916"/>
    <dbReference type="KEGG" id="lpl:lp_1291"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1092"/>
    <dbReference type="eggNOG" id="ENOG50309UQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560976_0_0_9"/>
    <dbReference type="OMA" id="MITVQDY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1118-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="173" mass="19712" checksum="EF5900F5F056F0D9" modified="2011-10-19" version="1">MPTIKDYYLPKRPTLLFSLHPEPTQAIINGTKILEYRRRFFARPFQAFVYTTGDNGGIQLFLRCDQGLQLVPEQLALVGALLQHDAPTTTAAYFEGAKAGLALPITAFTTLPNIPLAQLRRQFENFVTPRSYVFLDQPDRQAQLDWLLTQPCESLTILDWRKRYAALATLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNG1</accession>
    <name>F9UNG1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arcT</name>
        <name evidence="4" type="ordered locus">lp_1410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1410"/>
    <dbReference type="EnsemblBacteria" id="CCC78750">
        <property type="protein sequence ID" value="CCC78750"/>
        <property type="gene ID" value="lp_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1410"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1182"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_9"/>
    <dbReference type="OMA" id="MDYGWIE"/>
    <dbReference type="PhylomeDB" id="F9UNG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1211-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="53"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="373" mass="41604" checksum="037446094C5BE6C1" modified="2011-10-19" version="1">MKIAGFGVEAWLNAHEREATTDISQSSIAALTMAEIAALEDQQAPQDFYEELGAARLDYGWIEGSPRFKELVSQLYEQVPAANVLQTNGATGANHLAIYSLVEPGDHVIALYPSYQQLYDIPKSLGATVDYWHIHESAGWLPDIMELQRLIRPETKMILLNNAINPTGSLLDRTLLEQVVTLARSVGAYVLADEVYEPLDETPFVSIADLYERGIAVNSLSKTYSAPGIRIGWTATPSQAIADIFRKYRDYTMICGGVLNDQLAVRILAHRQRVLARNRELVSRNLKILTEWVAQEPRVELITPHGISVSCIKLIVPIDDETFCQQLLRDTGVLLVPGSRFDIPGHARLGYCTDTPTLQRGLDLLGQYLRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ7</accession>
    <name>F9UNJ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101412.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889300.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1456"/>
    <dbReference type="EnsemblBacteria" id="CCC78786">
        <property type="protein sequence ID" value="CCC78786"/>
        <property type="gene ID" value="lp_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1456"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1219"/>
    <dbReference type="eggNOG" id="COG4473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054332_1_0_9"/>
    <dbReference type="OMA" id="RKQRFYR"/>
    <dbReference type="PhylomeDB" id="F9UNJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1247-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010288">
        <property type="entry name" value="EcsB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05975">
        <property type="entry name" value="EcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037259">
        <property type="entry name" value="EcsB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="46472" checksum="2DE80BE96390B0FC" modified="2011-10-19" version="1">MNELFQTRLQQHLRRMLRYLRLVFNDHFVIALMFFVGGLGLAYSNWLKTLGPQQTWIVWVLGLLLWAGLSVSHIATLLEPADTVFLLPRERDVHAYFVKAWRYSWWLAQAVQVIFVGLTVPLLMIVDQMTGWSLLALLITQLALKDAQLTLSVTHLYQVKPSMKRWLRPLNWAGAFVTLAVGLLVTPWLSAAMAIAIAVGQRYLHQRIWSTTVIAWRDDIKAEANRMLGIYRFFNLFTDVPMVQGSVKRRRYLDWLLRWLPKDQQHAFGYLYTRGMLRGTEFSGLVVRLTVIGAVLLYFSGHGWLAMALDALFIYLIGFQLLPFYKQYDNIVFTHIYPLATKQRVKNFQRLLRNVLSLTGLIFLVAFWLSNAPLAQVGILLIINVIEIYLLVTWYLKLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK0</accession>
    <name>F9UNK0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889303.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1459"/>
    <dbReference type="EnsemblBacteria" id="CCC78789">
        <property type="protein sequence ID" value="CCC78789"/>
        <property type="gene ID" value="lp_1459"/>
    </dbReference>
    <dbReference type="GeneID" id="57025090"/>
    <dbReference type="GeneID" id="66449292"/>
    <dbReference type="KEGG" id="lpl:lp_1459"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1222"/>
    <dbReference type="eggNOG" id="COG5584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158531_0_0_9"/>
    <dbReference type="OMA" id="YTGTIID"/>
    <dbReference type="PhylomeDB" id="F9UNK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1250-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="11946" checksum="3721499DE421644D" modified="2011-10-19" version="1">MNKQLQYGGLLAVGMAGIAGGFSVGGLFKRLRRPTPNQILSQVKRAFLKEAPIEGSWIEMKKSPLQKFALRTDVYYGGITRYEDGQLVQYEFLADANTGSILDIYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNP0</accession>
    <name>F9UNP0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101447.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889343.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1502"/>
    <dbReference type="EnsemblBacteria" id="CCC78829">
        <property type="protein sequence ID" value="CCC78829"/>
        <property type="gene ID" value="lp_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1502"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1263"/>
    <dbReference type="eggNOG" id="ENOG50309JW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865425_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1290-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="321" mass="37739" checksum="9E1C618F7AE0AE2D" modified="2011-10-19" version="1">MAKFNFTLNAARMDASGHYDFQNVFEFPDFVEMRPTLRAAVRTVAREAFDQPVLPVKVERMTTSLEEQLERETRKYERQVGVYDNQKSERNQLVRLFTQVLQVISRTDEITEELEDIIYAVNQTRLSLIGLPALEGTGELYDADRDRELIVGTYYHFVTRLLVRPYLRDMQGDLVPENVTAAGRHLVVRMTTYAYRDWDAYLVHEYDEQHLIKNEKGLTNAAYYDKLEAVELKYADHIYAEVLADTYQEFVKVLVPNQLERFEIMSSDLRPLLAKNPGLRIRLAAIVNRHFKLDQDGYEHVMDTPLQEIKQKYQFYRENFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS7</accession>
    <name>F9UNS7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two-component system response regulator</fullName>
            <ecNumber evidence="8">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp5</name>
        <name evidence="8" type="ordered locus">lp_1544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889380.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1544"/>
    <dbReference type="EnsemblBacteria" id="CCC78866">
        <property type="protein sequence ID" value="CCC78866"/>
        <property type="gene ID" value="lp_1544"/>
    </dbReference>
    <dbReference type="GeneID" id="49393816"/>
    <dbReference type="GeneID" id="57025136"/>
    <dbReference type="GeneID" id="66449432"/>
    <dbReference type="KEGG" id="lpl:lp_1544"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1300"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="PhylomeDB" id="F9UNS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1327-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="228" mass="26372" checksum="54C48DE8A4DE488A" modified="2011-10-19" version="1">MSRILIIEDEKNLARFVELELKHEGYDIQVEYNGRKGLDAALAEDFDAILLDLMLPELNGLEVCRRVREVKNTPIIMMTARDSVIDRVSGLDHGADDYIVKPFAIEELLARLRALLRRIDLESEQQSTKQTTVTYKDLTIEKENLVVKRGDEVINLTKREYELLLTLMENINVVLARDVLLNKVWGYESEVETNVVDVYIRYLRNKIDRPGEKSYIQTVRGTGYVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNT1</accession>
    <name>F9UNT1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">sbcD</name>
        <name evidence="11" type="ordered locus">lp_1549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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        <property type="entry name" value="SbcD"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78893.1"/>
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            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
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            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
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    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="34500" checksum="A73E71E71AC565DF" modified="2011-10-19" version="1">MEKQNQPDLEKQDQPTRALTKRLQQKLDYVTTVRQAITAGDDRLIYELIDGDHYHQALLNEEPDPTRNAQVDLITDVYPAISHYLSTKLIDYLAHEYPFFYYEETQLGEFQIYFGNWWDRRRFGKLNVLKVAFEFSSEEYNKLQKTFELAPAHKRFNTDRIQQISAGSDQLQKLIDAQSDRDAQKEELRQQLKENGQRNSLFDSGRIKEERQQIIDQLTKLADEDEQANNAHATMKDNEAKILTLSKEDTILAYEKQAIENAFKSFENFNERNRSLYVDYLTTLIGKAQVAADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP44</accession>
    <name>F9UP44_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA carboxytransferase</fullName>
            <ecNumber evidence="3">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accA2</name>
        <name evidence="12" type="ordered locus">lp_1680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889497.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1680"/>
    <dbReference type="EnsemblBacteria" id="CCC78983">
        <property type="protein sequence ID" value="CCC78983"/>
        <property type="gene ID" value="lp_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1680"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1419"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_9"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="PhylomeDB" id="F9UP44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1446-MON"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="27573" checksum="096EF488E28C568A" modified="2011-10-19" version="1">MSKVTAYEQVQAARDASKISIQTLIDGLTEDFFDCHGDRQRADDPAVIAGLATIAQRPVTIIGIQKGQNLAENQARHFGCATPSGYRKALRLMRQAEQLRQPVVTLINTPGAYPGVDAEYEGQGRAIADCLLAGLQLRVPFLSLIVGEGGSGGALALACGDQVWMLANSTYSVLSPEGYATILWKESQRAAEAAEKMRLTPTELLADGIIDRIIPEVATAADCQPLKTAIDETLTALTAKSVAELVTQRQARYRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP46</accession>
    <name>F9UP46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheinyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889499.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1682"/>
    <dbReference type="EnsemblBacteria" id="CCC78985">
        <property type="protein sequence ID" value="CCC78985"/>
        <property type="gene ID" value="lp_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1682"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1421"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459579_0_0_9"/>
    <dbReference type="OMA" id="SVSHTHQ"/>
    <dbReference type="PhylomeDB" id="F9UP46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1448-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20839" checksum="193FB54D7712C7CA" modified="2011-10-19" version="1">MPITQVVFKRQWLQMPVDVSKKMRRVTQRTVSRQLIQQVLSVPLAYHRLGQPYFPSHPRLGVSVSHTHQLVMVAVGPGPLGIDVEQVRPYDVTAIRRAFTSVEWQLLQVLSVQDRYRLGWQLWTAKEAVLKLVGCGLTHAPRRVEVLDLERGLACYQTQLYQLTPLELPATHEGFLARPLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP54</accession>
    <name>F9UP54_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889507.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1692"/>
    <dbReference type="EnsemblBacteria" id="CCC78993">
        <property type="protein sequence ID" value="CCC78993"/>
        <property type="gene ID" value="lp_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1692"/>
    <dbReference type="eggNOG" id="ENOG5032MBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120980_2_0_9"/>
    <dbReference type="OMA" id="WMLPILF"/>
    <dbReference type="PhylomeDB" id="F9UP54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1456-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025671">
        <property type="entry name" value="HXXEE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13787">
        <property type="entry name" value="HXXEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="164" mass="19137" checksum="42569D8EA3E3BCBF" modified="2011-10-19" version="1">MHNFSSYWILPLIFMFHDFEELVFVPYWLKDHNPKIHGHVLFGGVNRSDILAAGIWEEFCMYLLLATVAYIMDSPLLVATATLPYLFHLIMHLVFVFNKRTYVPGAITAIIELPIIIVYLYGLTTLTKASLWEWIIVVIIMFVSFISNLKFIHWIMAKTMHKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP74</accession>
    <name>F9UP74_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">lp_1713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1713"/>
    <dbReference type="EnsemblBacteria" id="CCC79013">
        <property type="protein sequence ID" value="CCC79013"/>
        <property type="gene ID" value="lp_1713"/>
    </dbReference>
    <dbReference type="GeneID" id="57025342"/>
    <dbReference type="KEGG" id="lpl:lp_1713"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1447"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_9"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="PhylomeDB" id="F9UP74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1476-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="34"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="41"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="441" mass="48264" checksum="7B22B6A290EA7A2E" modified="2011-10-19" version="1">MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDYQISYASKAFATVAMYQLIAQEHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTMALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPGISAHTHDYISTGQADSKFGFDLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFYPQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATAGMTLYTIGDEKDIPGIRKYLSVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGKYCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYNRNPRPAVVFCEQGHSQLVVQRESYADLTRLDLPLSVPEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD5</accession>
    <name>F9UPD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol O-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cat</name>
        <name evidence="2" type="ordered locus">lp_1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.28" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889588.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1787"/>
    <dbReference type="EnsemblBacteria" id="CCC79074">
        <property type="protein sequence ID" value="CCC79074"/>
        <property type="gene ID" value="lp_1787"/>
    </dbReference>
    <dbReference type="GeneID" id="57025401"/>
    <dbReference type="KEGG" id="lpl:lp_1787"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1508"/>
    <dbReference type="eggNOG" id="COG4845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093121_0_0_9"/>
    <dbReference type="OMA" id="WNRKEHF"/>
    <dbReference type="PhylomeDB" id="F9UPD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1537-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001707">
        <property type="entry name" value="Cmp_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38474">
        <property type="entry name" value="PTHR38474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00302">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000440">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01059">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000440-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="25425" checksum="A6BADA1216B79766" modified="2011-10-19" version="1">MTTTKPNMHAVAINPEAWPRQTYFYYFTKIAPSGFSLTVNMDITATLAWTKAHHVKFNAVYLYLVSRLLTTHPEMRIGYLNDQLVTFDVLHPSYTILHADRTMANLWTTYDTDFETFYQHYLADQAEFSALPGPMPKTPQTPNLVNIGCLPGVHFSSYTPLPFKPLDSFFPIFQAGQFKKDADKTIMPLSITVNHATIDGDHLSRFFNELQSCWEQPTQYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI9</accession>
    <name>F9UPI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101570.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889642.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1857"/>
    <dbReference type="DNASU" id="1061526"/>
    <dbReference type="EnsemblBacteria" id="CCC79128">
        <property type="protein sequence ID" value="CCC79128"/>
        <property type="gene ID" value="lp_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1857"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1564"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_32_2_9"/>
    <dbReference type="OMA" id="FHFSEEI"/>
    <dbReference type="PhylomeDB" id="F9UPI9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1590-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="309" mass="35374" checksum="92C353A82E7748F0" modified="2011-10-19" version="1">MRIQQLRYLEKIATTGSINEAAKQLFISQPSLSQAMKELEKEYQVQLFYRHKTGITLTDAGREFINYSRSVLDQVNLLNEHFGQGTVRKRIFSVSAQHYAFVVNAFVELVKEIGGDTYQFTLRETETANVLNDVQTLKSELGVIYLNKFNQTVLSRLIADKDLSFVPLFEARPHVFVGRDNPLTHKQDLTLDDLRDYPYLSYEQGDTSSFYFAEEILSTLPHKKHIRISDRATIFNLMVGLNGYTISSGIISSELNDEKIVAIPLKVDDAMTLGYLRHKKIELSATAQRYLTLLKQHIQGYGFDVFNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPT5</accession>
    <name>F9UPT5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate starvation-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phoH</name>
        <name evidence="4" type="ordered locus">lp_1970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889738.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1970"/>
    <dbReference type="EnsemblBacteria" id="CCC79224">
        <property type="protein sequence ID" value="CCC79224"/>
        <property type="gene ID" value="lp_1970"/>
    </dbReference>
    <dbReference type="GeneID" id="57025549"/>
    <dbReference type="KEGG" id="lpl:lp_1970"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1664"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_9"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="PhylomeDB" id="F9UPT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1688-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="117"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35838" checksum="1D48A62E9F80A494" modified="2011-10-19" version="1">MFLTENSKYEQKFLIADPAQSVALLGPEDAHLALLEDGLHVQLHVFGDQMTISSDDEVAVHNTQAVLDNLTSLIKQGIQIGAPDVISAIKMVNRGTLDYFKDLYSETLIKDNRGRPIRVKNFGQRQYVQAVAKSDITFGIGPAGTGKTYLAVVMAIAALKRGDVEKLILTRPAVEAGESLGFLPGDLKEKVDPYLRPIYDALYDIYGAEHTQRLMDRGIIEIAPLAYMRGRTLDHAFVILDEAQNTTNAQMKMFLTRLGFGAKMIVNGDISQIDLPHHTKSGLIQAEQILGGISNVAFVKFTADDVVRNPVVAKIITAYDRVEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPT9</accession>
    <name>F9UPT9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640685.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889742.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1975"/>
    <dbReference type="EnsemblBacteria" id="CCC79228">
        <property type="protein sequence ID" value="CCC79228"/>
        <property type="gene ID" value="lp_1975"/>
    </dbReference>
    <dbReference type="GeneID" id="57025553"/>
    <dbReference type="KEGG" id="lpl:lp_1975"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1668"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_15_1_9"/>
    <dbReference type="OMA" id="HTVLYLM"/>
    <dbReference type="PhylomeDB" id="F9UPT9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1692-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="25106" checksum="16A4246B1C11031E" modified="2011-10-19" version="1">MTMQLKKQRLLVIGGTSGFGMAIARQALQEGADVHIIGHTAAHVTAAITQLGPSDHLTGTALDAQNLAQLKTFFAAQPAFDHVVSMLGGAMGGGFLDNSIAAIRQTVEDKFFANLQVAQLASHHLNQHGSLIFTSGAGGRPDNASGAIVGNQAINTMVVGLAVELAPDYRVNAVAPTWTPTGLWRQLSDAQLAAQAATVSAGNPLKRVATPAEVASAYVYLMQNEFMTGQVLHVDGGVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ05</accession>
    <name>F9UQ05_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cdsA</name>
        <name evidence="15" type="ordered locus">lp_2050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="13"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640734.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889808.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2050"/>
    <dbReference type="EnsemblBacteria" id="CCC79294">
        <property type="protein sequence ID" value="CCC79294"/>
        <property type="gene ID" value="lp_2050"/>
    </dbReference>
    <dbReference type="GeneID" id="57025600"/>
    <dbReference type="KEGG" id="lpl:lp_2050"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1735"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_2_2_9"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="PhylomeDB" id="F9UQ05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1755-MON"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="261" mass="28663" checksum="D322962387012369" modified="2011-10-19" version="1">MRQRVITAVVALILFIPVIFVGGVTLDIVAMLLGAVAMSELLVMRKKLLISFEAIVSMLAVMIQIAPNNWFNGLPDQLNKEYVVYFLVILLLLHTVWSRNRFSFDDAGMLTLGVLYIGMGFNYFTAARGVSVYMLLFLMFIVWLTDSGAYMVGRKLGRHKVTPISPNKTWEGCIGGSVIGVIVASAFAIGFHVGYASVISMVLITLVLSVVGQFGDLVESALKRYYGVKDSGKILPGHGGILDRFDSMLLVFPIAHLFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB3</accession>
    <name>F9UQB3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">iscS</name>
        <name evidence="9" type="ordered locus">lp_2180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101678.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2180"/>
    <dbReference type="EnsemblBacteria" id="CCC79402">
        <property type="protein sequence ID" value="CCC79402"/>
        <property type="gene ID" value="lp_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2180"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1843"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_9"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="PhylomeDB" id="F9UQB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1863-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="386" mass="42338" checksum="468102E9DF140AE5" modified="2011-10-19" version="1">MKQVYLDNAATTPMAASVIQTMTDQMTNTFGNASSTHAFGRAAREVLDDSRHVIAQSINAADDDIIFTSGGTESDNTAVMQTAWTRQHLGKHIITTAIEHQAILKSTAFLAEHGFEITYLPVNEQGQISLDDLKAALRPDTILVSIMTGNNEVGSQMPIHEIGELLKDHQAWFHTDAVQAYGLLDIDVQRDHIDMLSTSAHKINGPKFLGFLYRRNGINFPSFVKGGEQEDKRRAGTENIPAIAGFATAVQELTTAEKTHRQAKYREFKQYIVDQLTANGVDFEVNGSLGEHNLQHVLNLWIKGVSTYTMQTNLDLAGVAVSGGSACTAGSLEPSHVLIAMYGEDSPRISESIRLSFGRYTTKADLDQFVTVLTKTTQRLLKKQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC3</accession>
    <name>F9UQC3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">lp_2193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2193"/>
    <dbReference type="EnsemblBacteria" id="CCC79412">
        <property type="protein sequence ID" value="CCC79412"/>
        <property type="gene ID" value="lp_2193"/>
    </dbReference>
    <dbReference type="GeneID" id="57025721"/>
    <dbReference type="GeneID" id="66449946"/>
    <dbReference type="KEGG" id="lpl:lp_2193"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1853"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_1_1_9"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="PhylomeDB" id="F9UQC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1873-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="427" mass="45014" checksum="BF5AC95B2E8D3DC1" modified="2011-10-19" version="1">MEFSLDSTQNSGANIKVIGVGGGGGNAVNRMIAEDVKGVEFIVANTDVQALQTSNAETKIQLGPKLTRGLGAGSNPDVGSKAAQESEEALTEALQGSDMVFVTAGMGGGTGNGAAPVVAKIAKDSGALTVGVVTRPFTFEGPKRARNAAEGIAQMKDNVDTLIIIANNRLLEIVDKKTPMMEAFQEADNVLRQGVQGISDLITSPGYVNLDFADVKTVMQNQGSALMGIGSASGENRTADATKQAISSPLLEVSIDGAEQVLLNITGGPDMSLYEAQAASDIVSQAATTDVNIIFGTSIDESLGDEVRVTVIATGIDQKQRELKMDSQPSRSEASQQRGGMFATPTDQPATSEAAQSSESQANDPFGNWDIRREPNNSRPVNNGQEFNNVEKTDFDVFNDNSQADDSKDDNSGDSLDTPPFFKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF8</accession>
    <name>F9UQF8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein, DedA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641563.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889961.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2232"/>
    <dbReference type="DNASU" id="1061373"/>
    <dbReference type="EnsemblBacteria" id="CCC79447">
        <property type="protein sequence ID" value="CCC79447"/>
        <property type="gene ID" value="lp_2232"/>
    </dbReference>
    <dbReference type="GeneID" id="57025783"/>
    <dbReference type="KEGG" id="lpl:lp_2232"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1889"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_9"/>
    <dbReference type="OMA" id="PWYGIGR"/>
    <dbReference type="PhylomeDB" id="F9UQF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1932-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="218" mass="24479" checksum="BEA68BF4A0F825ED" modified="2011-10-19" version="1">MSFLIDFVLHIDQHLVTIVNSFGIWTYLILFAIIFIETGAVILPFLPGDSLLFAACALAANPTYGLHIWTFVILFLVAALAGDSLNFYIGHSLGERLTETSWFGRLINQKQLAKSEKFFEKHGGITVTIARFMPIIRTFVPFVAASSRMKYQQFIRYNVIGCVLWVILCCGGGYYFGNIPFVKEHFSMVVIGIILVSLIPAVFSAIRARFSHPTENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL4</accession>
    <name>F9UQL4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="6">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">pgsA</name>
        <name evidence="19" type="ordered locus">lp_2303</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890017.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2303"/>
    <dbReference type="EnsemblBacteria" id="CCC79503">
        <property type="protein sequence ID" value="CCC79503"/>
        <property type="gene ID" value="lp_2303"/>
    </dbReference>
    <dbReference type="GeneID" id="57025839"/>
    <dbReference type="GeneID" id="66450051"/>
    <dbReference type="KEGG" id="lpl:lp_2303"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1947"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_9"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="PhylomeDB" id="F9UQL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1987-MON"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCC79503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="194" mass="21369" checksum="D1243F2266ACEE7D" modified="2011-10-19" version="1">MNLPNKLTVFRIILIPVFILIMVLPLSWGQVVWAGTTIPVTQVVATVIFAVASLTDLADGKIARGQHLVTNFGKFADPLADKMLVMTAFIILVRLNAAPDWVVAIIMCRELAVTGLRLLIVENNGKVMAAAMPGKIKTTTQMIAIIFLLLNNVLFAAIHIPFAAIMLYICLFFVIYSGIDYFVQNRDVFADGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT1</accession>
    <name>F9UQT1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101727.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2388"/>
    <dbReference type="EnsemblBacteria" id="CCC79570">
        <property type="protein sequence ID" value="CCC79570"/>
        <property type="gene ID" value="lp_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2388"/>
    <dbReference type="eggNOG" id="ENOG5030AY6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2916844_0_0_9"/>
    <dbReference type="OMA" id="EWVSTGI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2055-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="61" mass="6992" checksum="5BC701BC917AC42F" modified="2011-10-19" version="1">MIKWSNRHWQAVEWVSTGILVGCTLLYNHQVVSNQWLLVIGGAALISYWLVTLPRLFGSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT5</accession>
    <name>F9UQT5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_2394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2394"/>
    <dbReference type="EnsemblBacteria" id="CCC79574">
        <property type="protein sequence ID" value="CCC79574"/>
        <property type="gene ID" value="lp_2394"/>
    </dbReference>
    <dbReference type="GeneID" id="57025918"/>
    <dbReference type="KEGG" id="lpl:lp_2394"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2019"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_9"/>
    <dbReference type="OMA" id="FSYLWFM"/>
    <dbReference type="PhylomeDB" id="F9UQT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2059-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="386"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="419"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="629" mass="70074" checksum="10BEE215C9CE2603" modified="2011-10-19" version="1">MSEKNTSSTKPARPAGGHGPGGHAGLVEKPKSFWKTAIRLMRYMSDRWVGLAVVMIFAIASVIFQIRTPKILGKATTELYKGIMKGAAQQKAGISQSGYPINFEKIGQIIMIVLIMYLASALFNFIQQYIMTRISQRTVYKLRRSFKGKMQKVPISYYDTHSNGDIMSRAVNDMDNIANTLQQNLTQAVTSTVTFVGTLWMMLTISWKLTLIALVTIPLSVVVVGVIAPKSQKFFGTQQKSLGLLNNQVEENYAGHVVIKSFNKEQDAIDDFEIQNNNYYQSAWKAQFISGIIMPLMMFLNNIGYVFVAIIGGIDVANGNVSLGNIQAFLQYTQQFSQPISQMANLLNTIQSTVASAERVFEVLDEEEMKQTKSNLPAEPDSDNLISLQHVQFGYADNDLLMKDYNLDVKRGQQVAIVGPTGAGKTTIINLLERFYDIKGGSIKLKGTDTRDLDREDLRSHFAMVLQDTWLFTGTIFDNLKYGREDASDEEIYAAAKAAHVDSFVRKLPDGYQTVLNEEASNISQGQRQLLTIARAFVANPEILILDEATSSVDTRTEVHIQHAMERLLKNRTSFVVAHRLSTIQGADNIIVMNHGSVVETGTHEQLMAQNGFYADLYNSQFTGNISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU4</accession>
    <name>F9UQU4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2404"/>
    <dbReference type="EnsemblBacteria" id="CCC79583">
        <property type="protein sequence ID" value="CCC79583"/>
        <property type="gene ID" value="lp_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2404"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2030"/>
    <dbReference type="eggNOG" id="ENOG5031UNB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758190_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2068-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="380" mass="39516" checksum="DFE70990C7CC6588" modified="2011-10-19" version="1">MEKTLNFTDTSPQTVKIGDTTTSFTLICGNDNMSVDLTHANSITVKLGNASGYLKSTTIDPTSLIDPTAGQVTVKFDADLMTSLPAGSYAIEVWVVDSTGTSIYPSDGSAGFTITNNIQNTIGETITTITFDDFVKAMNKAAHTIAKGDKGDTGPQGKQGEPGPIGKTGPQGATGPQGAKGDTGTVDNAGLTTAPAFVELKTQVNNSAVGTNLITNSNFSSGLNHWYINPGDKKDCKATATTDSDGDTCIHITGTGNACGLYCSPVSFNQNQITTGSVLAKGTGTLLMVGLEGRQVSTFGTTSTESYSKVSSTMQASSSTNNFVIYFGLVDGIVDAYIKFPKLEIGSHETDWCPNSSEVLTQSDYAKIKAAIVSLGGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR04</accession>
    <name>F9UR04_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 11, head-to-tail joining</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101794.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890157.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2470"/>
    <dbReference type="DNASU" id="1062593"/>
    <dbReference type="EnsemblBacteria" id="CCC79643">
        <property type="protein sequence ID" value="CCC79643"/>
        <property type="gene ID" value="lp_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2470"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2081"/>
    <dbReference type="eggNOG" id="ENOG5030A1G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163964_1_1_9"/>
    <dbReference type="OMA" id="TTKQQFV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2135-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008767">
        <property type="entry name" value="Phage_SPP1_head-tail_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038666">
        <property type="entry name" value="SSP1_head-tail_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05521">
        <property type="entry name" value="Phage_H_T_join"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01563">
        <property type="entry name" value="gp16_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12313" checksum="0C77DD54C92F7A80" modified="2011-10-19" version="1">MKNYNLSRLNKRVQFGTVKTVQNLINGTTKQQFVPLFTVWYGEYTLTISNTISLTGMTATTNQLIAVRHDDRITTALVAILDGVTYKVAGVSSDSDLNAYDVVTLTKVNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR64</accession>
    <name>F9UR64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH peroxidase</fullName>
            <ecNumber evidence="5">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">npr2</name>
        <name evidence="5" type="ordered locus">lp_2544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101823.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2544"/>
    <dbReference type="EnsemblBacteria" id="CCC79703">
        <property type="protein sequence ID" value="CCC79703"/>
        <property type="gene ID" value="lp_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2544"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2139"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_9"/>
    <dbReference type="OMA" id="WVSHAPC"/>
    <dbReference type="PhylomeDB" id="F9UR64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2195-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="331"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="451" mass="48256" checksum="F92F6CD3F03A8144" modified="2011-10-19" version="1">MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSYATPAGMQAQGVHVFVNSEISKVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPVPGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYIGIEAAEVFAKAGMHVTVIDLLPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVVTAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALATNARRQGRIAAKNLLGENVPMPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVTDTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYDVTANINAISVAIQAKLTVADLAYTDFFFQPGFDRPWNIINVAAQKAAATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB0</accession>
    <name>F9URB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Catabolite control protein B / transcription regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpB</name>
        <name evidence="5" type="ordered locus">lp_2602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101849.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2602"/>
    <dbReference type="EnsemblBacteria" id="CCC79749">
        <property type="protein sequence ID" value="CCC79749"/>
        <property type="gene ID" value="lp_2602"/>
    </dbReference>
    <dbReference type="GeneID" id="57026010"/>
    <dbReference type="KEGG" id="lpl:lp_2602"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2185"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_14_0_9"/>
    <dbReference type="OMA" id="RANEWET"/>
    <dbReference type="PhylomeDB" id="F9URB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2240-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="34923" checksum="40D85F0259FFAE9E" modified="2011-10-19" version="1">MTNIHDIARLSGYSVSTVSRVINHQKYVADDKRKKIEALIKELDYVPNRLARDLSKGQTKTIGIVLPYANHPYFARIVDGIVSAGFAKGYKVTLLPTNYDMTVERHYLEQLKSKAYDALIFTSRSNSLEALERYQKYGRIVCCEDPGTSSHLAAAYTDRLASYISALMWAKQQGCQNVGVVISRDNLISASSRVTRMAYQETYGKLPAANLFTGAVTFEDGYRAGRYFAKLKPSVDAILANGDDIGAGIQDYYRVHQLTPVKIIGQENLLSSRLMQFSTIDHHLEALGKAAFELSISHGQKHQLIKSEFIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF3</accession>
    <name>F9URF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890306.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2663"/>
    <dbReference type="EnsemblBacteria" id="CCC79792">
        <property type="protein sequence ID" value="CCC79792"/>
        <property type="gene ID" value="lp_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2663"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2231"/>
    <dbReference type="eggNOG" id="ENOG5031PIN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080089_1_0_9"/>
    <dbReference type="OMA" id="GKVMKYN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2283-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="259" mass="28761" checksum="F993BE6349659D54" modified="2011-10-19" version="1">MDNLIKNNGIVLLVIIVLPGLFAWLLTIINRQTKANLVNHYGINSQVYCGFLGIIIHELSHLILALIFRHGIQSVRLLKRPHLHPEDESADDLALGYVNHTWNRHSRYQVIGNLFIGVAPIFGCTAALLGLDWLLAPGLFQAIFKLADTPEQPQWAASFHALTSTPTSWWQLLMLLFLTLVIVIGGFDLSPADYQNSAIGLYSTIVIIIVLTTLLTFIGITGWIHTLVTWGLMVAIILGYSLLVSLLVMLVTHLLTNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG9</accession>
    <name>F9URG9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">araT2</name>
        <name evidence="4" type="ordered locus">lp_2684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890322.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2684"/>
    <dbReference type="EnsemblBacteria" id="CCC79808">
        <property type="protein sequence ID" value="CCC79808"/>
        <property type="gene ID" value="lp_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2684"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2247"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_9"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="PhylomeDB" id="F9URG9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2299-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="390" mass="43039" checksum="29653949CA2DCF66" modified="2011-10-19" version="1">MMNTNIRIQQIQVSGIRRFDEAISQIPDIIRLTVGEPDLPTPSHVKKAAIQSIHNDWTHYSPLMGFAALQDAASHYFQQKYQLTYAPEQIIATVGASEAVATTLLTLLNPGDTVLLPTPAYTNYQPVVDIANAQLAPIDTTATGYKLTPSALQAALDDHRHDHVKALILNYPTNPTGVTYTDDELWALQAVIATAGIYVISDEIYSELTYEQPHTAFATLYPSKTITINGLSKSHAMTGWRLGFIMAPSNLITEMKKTHQYLVTSTSSITQAAGIEALTHGLDDGSEMRGVYQTRRDYVVKRLSEIGFNYIYPTGAFYIFVQLPQDFQGTSWDFATRLAHEAQVAVVPGSAFGTSGEGWFRISYAASQSALREGLNRLALWRAQTTTQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ4</accession>
    <name>F9URJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine synthase (Cobalamine-independent) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101890.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890347.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2718"/>
    <dbReference type="EnsemblBacteria" id="CCC79833">
        <property type="protein sequence ID" value="CCC79833"/>
        <property type="gene ID" value="lp_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2718"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2273"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058877_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9URJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2324-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24881" checksum="589793CD85916D5A" modified="2011-10-19" version="1">MEFGTLMMMVRHRVHGWQMAMRSQKGLHRGTTTLNINAAGLKRMEDAAFMHHIRKPVDKSHNLNWWHFNFFWGLQGITQSGIGLVPALALTGKISGFNHPAVAHFEFMRNQISGGTVDKQILAAPELCLAELKRSDNARALNRVYQSDTEMVHDLAAAYHQIMSDLYRVGARTIQLNRQGLGSQQGCSITELGTQVSREAVRDLPADLCVEWHVTHGTCYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL9</accession>
    <name>F9URL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644733.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890372.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2745"/>
    <dbReference type="EnsemblBacteria" id="CCC79858">
        <property type="protein sequence ID" value="CCC79858"/>
        <property type="gene ID" value="lp_2745"/>
    </dbReference>
    <dbReference type="GeneID" id="57026118"/>
    <dbReference type="GeneID" id="66450395"/>
    <dbReference type="KEGG" id="lpl:lp_2745"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2298"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="IDYHIRY"/>
    <dbReference type="PhylomeDB" id="F9URL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2349-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17128" checksum="BD032BDF40954136" modified="2011-10-19" version="1">MVQEYSNILVPLDGSQQAEIALDKAVAVAKRNEAHIDVLAVIDPGQFGYNLAGLADGDITYQLVQDSEAYLKETVDQVKKDGFTDIAFHIRMGSPKPIISQDFVKDHHNDLIMMGATGLNAVERVLEGSVTTYVQRNALTDVIVVKTDLQNTQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV2</accession>
    <name>F9URV2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644757.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890455.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2850"/>
    <dbReference type="EnsemblBacteria" id="CCC79941">
        <property type="protein sequence ID" value="CCC79941"/>
        <property type="gene ID" value="lp_2850"/>
    </dbReference>
    <dbReference type="GeneID" id="57026206"/>
    <dbReference type="KEGG" id="lpl:lp_2850"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2383"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046841_1_1_9"/>
    <dbReference type="OMA" id="FGYLIMM"/>
    <dbReference type="PhylomeDB" id="F9URV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2438-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="405" mass="44976" checksum="457904C1AC4A435A" modified="2011-10-19" version="1">MNKTWIVTFETYLRQIKSWSFLSLVFMPFLFFGFVAAFSYFAAPSASKNDIAVVSTSPQLRTSFIKQSHVATANKYQTLASAKAATKRNDIAGYLVLTTKNQQLQAQFTGPNAVSSGDKAKIQQFLATAQSQRNVQRAQLSAKQTQALTVQPKFTEQLQKHAASDKTAKTVSFYIVVFFVYLILTTYSAITAQEIAADKGTKIMEVIFSSTTPRKYFNGKIYGVLLVIVTQLLVYLVGGFAVMQFVKRSSLTIDFWQQNTDLINQVIHNLVSINLLFALLAVLLYTVASAFCGALVTRVADASKAAQPVIYLSMLAFFMALAFQNTPTNLFVKIFSYIPFFSSYFMPLRLINGMATMPAAIVSLLILIATIIGSMIYIGRIYGGLMLQTDELGFWGNLKRGLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW6</accession>
    <name>F9URW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2865"/>
    <dbReference type="EnsemblBacteria" id="CCC79955">
        <property type="protein sequence ID" value="CCC79955"/>
        <property type="gene ID" value="lp_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2865"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2398"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108859_2_1_9"/>
    <dbReference type="OMA" id="KCGFRIQ"/>
    <dbReference type="PhylomeDB" id="F9URW6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2452-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="165" mass="18021" checksum="D405BCF755E83960" modified="2011-10-19" version="1">MKIQPLAAAQIPRDLLLLADPSWAQVIAYLSTGQCYGYQQDGQVVGVVVLTTLKTGVWEVKNIAVAPAYQHRGIAKALLATAIAVCQAAPTCDELQIGTGNSSLRQLAIYQYAGFEMIEVWVNFFVDNYPDPIYEAGLQCKSMVRLSMSTTGEVAQRVENESFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY2</accession>
    <name>F9URY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063282"/>
    <dbReference type="EnsemblBacteria" id="CCC79971">
        <property type="protein sequence ID" value="CCC79971"/>
        <property type="gene ID" value="lp_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2885"/>
    <dbReference type="eggNOG" id="ENOG5030BKC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501686_0_0_9"/>
    <dbReference type="OMA" id="GPIKEIQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2468-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="20931" checksum="3212CAECE2DA3DC3" modified="2011-10-19" version="1">MSSYSNELLMLIFRSMLCKQVLIFFAYSGLYYLVTYFMDKKIQHQKQFLLKLGLVKLKKRNKTRWEKIRWRMQLCLIVSILVLVVSTFVLNPDDQYILLVIYVMKLATFTSFAIAFVDSLGPIKEIQQLIVGAQSSDTLDSDKKVLTVTIFKKIRWMLILYQVLKVPALIIILTLSVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC6</accession>
    <name>F9USC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family,C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2996"/>
    <dbReference type="EnsemblBacteria" id="CCC80056">
        <property type="protein sequence ID" value="CCC80056"/>
        <property type="gene ID" value="lp_2996"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2996"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2954831_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USC6"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="59" mass="6870" checksum="0271380EE1E1D535" modified="2011-10-19" version="1">MAQPLVSHQLAILFQYQLVSKTKRGKHVYYCLDDPHILEMVDAMIGHVAHEIKHEPHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG8</accession>
    <name>F9USG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/oxidoreductase,classical SDR family, subgroup 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644885.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890612.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3045"/>
    <dbReference type="EnsemblBacteria" id="CCC80098">
        <property type="protein sequence ID" value="CCC80098"/>
        <property type="gene ID" value="lp_3045"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3045"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2544"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_0_9"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="PhylomeDB" id="F9USG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2591-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="296" mass="31515" checksum="E726938FD4192104" modified="2011-10-19" version="1">MNQPELRDPRYLYKTDGFDKQDQETPALQAKMRPEPDCGEKSYQGHDKLLNRRVLITGGDSGIGRATAIAFAREGADVAIQYLPGEEPDAEAVAELVRAAGRQALLLPCDFKDVDVVTDLVDRTIAEFGGIDTLVLNAGQQISQPSLAKLPIEQVRATFEVNIVAMFALAQAALPKMPAGGSIVTTTSIQAYAPSGHLLDYAATKAAIKNFTINLAAEAAEKGIRVNGVAPGPIWTPLQLDQGQPIEALPKFGQDTLLKRAGQPAELAPVYVFLASNDASYVTAQIYGVTGGGVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI1</accession>
    <name>F9USI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system histidine protein kinase sensor protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpk9</name>
        <name evidence="3" type="ordered locus">lp_3063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890625.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3063"/>
    <dbReference type="EnsemblBacteria" id="CCC80111">
        <property type="protein sequence ID" value="CCC80111"/>
        <property type="gene ID" value="lp_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3063"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2558"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650188_0_0_9"/>
    <dbReference type="OMA" id="QIPTHEA"/>
    <dbReference type="PhylomeDB" id="F9USI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2604-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="320"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="422" mass="47213" checksum="37F8650389BBD8CC" modified="2011-10-19" version="1">MIGFREYVTWRIAIIWLSLVIITMSLGEVASNLWPQVPLAYFWIIPIVCVTTFMSSRLLYTQWILMLPVAIFLNALKRLVGAIMGVIAKAVAQSASPMLLRQAIGLHSTADINLFLASIMMLPVIIILGMLAHRWLVQVSAADFLQRARVNISDYLLVILFFAIYIIAYVFAMEWSVNAQTYMAIAAIVTFGIIGSYLISNKNSHLNDAQLLLQVSNYNELLSHHNRDLHLFKHDYENILLSMSAFIQNNDMAGLKRYFTTEVMPARVTLNRQSGLSDLSRLDMPTVSGLIYAKYEAANGQNVHLVVTILEKVTLADIPQIKVVRILGNLLDNATDAAARANHQVALTVKNRDAHTTVFSITNQIPTHEAVDLSVIKKSRFTTKPGHLGYGLSSIEQLTTDQLVVNYCIEEGNFIAELIIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL8</accession>
    <name>F9USL8_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Iron chelatin ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC</name>
        <name evidence="5" type="ordered locus">lp_3104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642350.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890662.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3104"/>
    <dbReference type="EnsemblBacteria" id="CCC80148">
        <property type="protein sequence ID" value="CCC80148"/>
        <property type="gene ID" value="lp_3104"/>
    </dbReference>
    <dbReference type="GeneID" id="57026414"/>
    <dbReference type="KEGG" id="lpl:lp_3104"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2594"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_9"/>
    <dbReference type="OMA" id="SHQVELM"/>
    <dbReference type="PhylomeDB" id="F9USL8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2641-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="28947" checksum="42AD66A010955D5C" modified="2011-10-19" version="1">MNTIEAQNISIGYGDKVIVDQLSITIPHGQITTLIGPNGSGKSTLIRAIAHLLPPTTGVILLDHQNIQQIKSKTFAKKIAVLPQTNQTANDLTVEELVSFGRLPYRRPLSGLTTTDHQKIEWALTQASLQDLRQRPLSTLSGGQRQRAWIAMAVAQDTDTIILDEPTTYLDLTHQLEVMQLVKKLNEQAHRTIIMALHDLNHAARISDQLIALKDGHVLAHGPVSTVMTAANLKTIFNIDATLVDYHGTPLILTYNGCQEVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP4</accession>
    <name>F9USP4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, DUF 1093 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3134"/>
    <dbReference type="DNASU" id="1063873"/>
    <dbReference type="EnsemblBacteria" id="CCC80174">
        <property type="protein sequence ID" value="CCC80174"/>
        <property type="gene ID" value="lp_3134"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3134"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2622"/>
    <dbReference type="eggNOG" id="COG5294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126418_1_0_9"/>
    <dbReference type="OMA" id="KNANHIG"/>
    <dbReference type="PhylomeDB" id="F9USP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2667-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006542">
        <property type="entry name" value="DUF1093"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036166">
        <property type="entry name" value="YxeA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36433">
        <property type="entry name" value="PTHR36433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06486">
        <property type="entry name" value="DUF1093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159121">
        <property type="entry name" value="SSF159121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01655">
        <property type="entry name" value="yxeA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="14132" checksum="E110752824E1C88B" modified="2011-10-19" version="1">MKKAGILGLIITIIVLVPVGLGFNWYHSNYGTKTYYTQITTKGERKTGKDDSGKPYVYYHYSQPGYSDNGVKKELTFDSVLPRSLKMHAYLKVGYNDKRQQVINWEKVNQKDIPQAALNRIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV8</accession>
    <name>F9USV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646329.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888203.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0137"/>
    <dbReference type="DNASU" id="1061331"/>
    <dbReference type="EnsemblBacteria" id="CCC77689">
        <property type="protein sequence ID" value="CCC77689"/>
        <property type="gene ID" value="lp_0137"/>
    </dbReference>
    <dbReference type="GeneID" id="57026976"/>
    <dbReference type="KEGG" id="lpl:lp_0137"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.113"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_9"/>
    <dbReference type="OMA" id="GYGTMQL"/>
    <dbReference type="PhylomeDB" id="F9USV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-111-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="31891" checksum="427507456F9FBE7F" modified="2011-10-19" version="1">MTTINAANAGTYAFDDQFKVNRMGYGVMQLTGPGTWGPYADPENGVKVVKKALEYGVNFFDTADSYGPWFADRYLAAGLKDAANRDQIFISDKVGQTRQGPNVWTPLGEPRYLRQQVEVSMMTLGIDHEDLVFLHRIDPHYSIADQVGELKKLQDEGKIKHIGLSQVTVDQIKEAQQVAKIDAIENLYNVANHGDDDVVDYAASQKMAFLPWFPLATGELAQAGSVLSTMAQKYQVSPAQIALAWLLKRSDNIIPIPGTSSIEHLRDNVAAANVDLTTADFNGLSQLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT31</accession>
    <name>F9UT31_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepD1</name>
        <name evidence="6" type="ordered locus">lp_0228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0228"/>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="CCC77762">
        <property type="protein sequence ID" value="CCC77762"/>
        <property type="gene ID" value="lp_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0228"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.190"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_4_1_9"/>
    <dbReference type="OMA" id="TWYGQKL"/>
    <dbReference type="PhylomeDB" id="F9UT31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-184-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="471" mass="52530" checksum="1F49F24FF8E0C474" modified="2011-10-19" version="1">MKKDTDCTEILVGKTASMDGSTIVARNEDGYGPINPIKFIVHEAHDQTNASYTSVTTGVTVPLPDHAYRYTATPQADQSDGQYEEAGINELNVGMSATETTATNARVLGYDPLVHDGVDEEAMVTLVLPYIKSAKEGVQRLGALIEKYGTGESNSIAFNDHDDIWLFETAGGHHWGAVRMPEDTYAIVPNQTVVQEMDLNDTDNFLGASDLVDFVEKYHLNPTPGHFNFREIFGTQSEADAYYNTPRTWYGQKLFNPEIEQNPTDQNMPLFRQPSKKLAIEDVQFFLSSHYNGTPYDPFGTFASGNAREQTRYRSIAMDRNQCSSILQIRNDVPAKQAAIQWIALGFFAYAPYVPFFTNINDTPIDYRNTTSTVSVDNVYWLSKTLSVLIEPHWHEFAETVNAYRDECQSYARGRVAATDAAIAGNPTDFLTKANSETAAEISNRTHALFDTLVKQGLLLSKTTWEKGQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT62</accession>
    <name>F9UT62_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, trehalose-specific IIBC component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts5ABC</name>
        <name evidence="16" type="ordered locus">lp_0265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888307.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0265"/>
    <dbReference type="EnsemblBacteria" id="CCC77793">
        <property type="protein sequence ID" value="CCC77793"/>
        <property type="gene ID" value="lp_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0265"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.220"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_10_0_9"/>
    <dbReference type="PhylomeDB" id="F9UT62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-215-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="179"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="303"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="653" mass="67469" checksum="D9495C2373E6482A" modified="2011-10-19" version="1">MGKIDEVSILAPVTGQVLSLATVPDPVFAAGRVGPGFGVQPTAGHILAPVSGRITVVATTKHAIGMVTTTGLEVLVHLGVDTVALNGAPFEVHVKVGDEVTAGTLLVDMDLAAIEQAHKPTTVIIVVTNAQRVLTDLTLAPLPQAVAAGAVVATAHLITVTTTASPVVAAVTQSTTRYSALATAIVANVGGQQNINSVIHCITRLRFYLKDEALAHDAVIANLDGVIDVAKAGGQYQVVIGPAVNDVFDAVIAQLGPEFADGVPVPPVQEASSDVNWLSHVRNGISGVIGVMTAAMIPVIGILAGSGILKGILAALTGFKVLAVTSGTYMVFNAVADATFYFLPVVLGFTAAKKLGSDPIVLAIVGAVLIYPSLITAASKGATAQITFLGVPTHLMSYSASVFPMIVAAWLGVYVERGLKRVVPLYLRSVFIPIIEALILAIVVLVVVGPLITIISKGLANGLVAVYNFSPALSGLVIGGLYQTMVIFGLHWGIIPIVINDIATNGHSYLNAILSITMVAQGGAVLAVFLKSKDKHLKEISLAAAISAFCGVTEPALYGVNLKYKRVFVVASIASGLGGLLTGLLRVNNYALSGSLIGFPAFITPGVGIGSNFYGYLISHYGTLVIATMLVYVFGFSDKLLGPKENLKATNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT71</accession>
    <name>F9UT71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell surface protein, ErfK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642392.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890703.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3155"/>
    <dbReference type="EnsemblBacteria" id="CCC80189">
        <property type="protein sequence ID" value="CCC80189"/>
        <property type="gene ID" value="lp_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3155"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2637"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089260_1_0_9"/>
    <dbReference type="OMA" id="GMGADYW"/>
    <dbReference type="PhylomeDB" id="F9UT71"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2680-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388140" evidence="4">
        <location>
            <begin position="42"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="24178" checksum="24FBC6C9787EA3C9" modified="2011-10-19" version="1">MKLTTKFILYLTLSFSGIVLLFGIRSMVRNSFAFEATRAQAASTSHSNSSHTKSKTRKSSVSHKTAAATATPVDWHGPSESNHPYPNVQNYPNLRIDVSVAKQRVYLKAGNKLLYTMLATTGKPGANATPKGDFVIQPERGLHFYNASLNEGANYWVSFKDHGVYLFHSVPVDASDHYIASKAALLGKRSDSHGCVRLSISDAKWMYEHIPVNTPVHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT82</accession>
    <name>F9UT82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890714.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3169"/>
    <dbReference type="EnsemblBacteria" id="CCC80200">
        <property type="protein sequence ID" value="CCC80200"/>
        <property type="gene ID" value="lp_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3169"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2648"/>
    <dbReference type="eggNOG" id="ENOG5030A9A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2538351_0_0_9"/>
    <dbReference type="OMA" id="QVEMMKI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2688-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9933" checksum="44A9157B2CB83BD0" modified="2011-10-19" version="1">MELKLNMSEKVAADEVTQREMIRIIGLFRKQGFKGNYLSFQHVADEGAAYFVVMGDENNGNQGLFKANLLTGDVAFQYMLDEDHVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD5</accession>
    <name>F9UTD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890767.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3234"/>
    <dbReference type="DNASU" id="1061710"/>
    <dbReference type="EnsemblBacteria" id="CCC80253">
        <property type="protein sequence ID" value="CCC80253"/>
        <property type="gene ID" value="lp_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3234"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2701"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="HCMTGHA"/>
    <dbReference type="PhylomeDB" id="F9UTD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2741-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="33053" checksum="9B65090AFF86118D" modified="2011-10-19" version="1">MDLQYLDNFLALAHYRSFSAAADACYISQSSFSKRIMRLENNLGVTLFERSTRQVSLTEYGQIYLKYAQQIKTLSRQATDEINRRHAEDEGIVIGGIPSISEYGILDLISGFIKTTHIHCQVKSAPSEDLEPMLLNQTLDFAFIKEVHHTNLFYQLPYAEDHLVAVLPANHPLANLSEIKLQQLANEDFIFQPVNSRPYELCMMICKQNGFTPNVIYADRIIENILNFVKKGLGVSLLMEKLVPKDSELICLPIHPAVVADINLCYLKKEPLSQYGYAFLNYFSHQNNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE1</accession>
    <name>F9UTE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease III</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nth2</name>
        <name evidence="2" type="ordered locus">lp_3241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="222" mass="25495" checksum="F533FFD965B0CD87" modified="2011-10-19" version="1">MTIETLYQQMLAAMGPRHWLQAGIPPAETPWEILWGGILVQNTNWRNVDYALANLKAATDFEPRQLLALTDTELTTLVKPAGFYTRKVPTLKALAAWCGQYDFDLTVMRALPAEQLRRELIALRGIGDETADYFSMYVFHQPTIIIDTYLRRLFGWLNQPLPSNYLKAQQLIMQAWHYDLTTAWEWHALIVDFGKQVKTTADFERSFLATQRLTLASQSLAN</sequence>
</entry>
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    </gene>
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    </organism>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCC80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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    <dbReference type="OMA" id="MFAYLAV"/>
    <dbReference type="PhylomeDB" id="F9UTL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2821-MON"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:amino acid transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="lpl:lp_3355"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2798"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="SGQIARW"/>
    <dbReference type="PhylomeDB" id="F9UTM7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2834-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="23543" checksum="693EFD69B3A791F3" modified="2011-10-19" version="1">MTNVLILGAAGQIARLAEQQFLANTTDNLTLYLRNSSRVADQQSDRVTIIDGDTTDEAKLTQAMTGQDVVYANLAGQNIKQQAETVLKAMHTSGLKRLIWISTLGIYDEVPGKFGQWNNATLGSYLTRYYAAAEVLENSDLDYTIIRPAWLTNKDEIDYEITQRHDPFKGTEVSRKSIAALVVKLTQDPTSNIRTSLGVNKPNTDGDKPAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN6</accession>
    <name>F9UTN6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641855.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888320.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0280"/>
    <dbReference type="EnsemblBacteria" id="CCC77806">
        <property type="protein sequence ID" value="CCC77806"/>
        <property type="gene ID" value="lp_0280"/>
    </dbReference>
    <dbReference type="GeneID" id="57027093"/>
    <dbReference type="KEGG" id="lpl:lp_0280"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.233"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_9"/>
    <dbReference type="OMA" id="CSFAAQG"/>
    <dbReference type="PhylomeDB" id="F9UTN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-228-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="50411" checksum="6454DA978CC44466" modified="2011-10-19" version="1">MKTTTRSWLAMIVIGIFTIMANLDASIINIALPIMSKSLAVPISQITYTVMGYMVILSGLLVTFGKLGDIWGKGRIFTLGMYSFTIGSLMASVNFGFEFLLLARFVQAVGAAATLSNSYGLISELFDNHTRGTAMGINTMFISAGFVAGPALGGFLLQQFAWNAIFMINIPLGIIAIILGHLFLPKNHGRQQATKLDGWGAGILFIIITLFFVVLEAGQTIGFRQPLIIIGFIITLALTLYFIYLEKHRKNALLPLSIFKNRTFSLALLVGMLIPLINALFSFIFPLYLQDYLNWSVGTTGILMLIFPLIMAIAAPLGGWLSDLFSQQLVLLTGLVLIIITQIGFLFLDSHTSLTLIISLLISNGIGTGFFIAPNNTLLMSVVPQNQLGVAGSLQSLGNNIGNILGVALGSLALFTTMSIDAGYRVSTYLPAHPAWFAHGLTWSFSVSLICALLGFAISIINRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP4</accession>
    <name>F9UTP4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641863.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888328.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77814">
        <property type="protein sequence ID" value="CCC77814"/>
        <property type="gene ID" value="lp_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="57027101"/>
    <dbReference type="KEGG" id="lpl:lp_0289"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.242"/>
    <dbReference type="eggNOG" id="ENOG5030ADC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2523381_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-236-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="84" mass="9727" checksum="355B24545FCFAAFD" modified="2011-10-19" version="1">METGILKQIDLTTTTERYFFVQVQRLADYVWIRSVQNFKPLELTVRVSDLQVNKHQAVADRGNIKYEFNDDTGGLVTQLAGWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS7</accession>
    <name>F9UTS7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641899.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0324"/>
    <dbReference type="EnsemblBacteria" id="CCC77847">
        <property type="protein sequence ID" value="CCC77847"/>
        <property type="gene ID" value="lp_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="57027137"/>
    <dbReference type="KEGG" id="lpl:lp_0324"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.275"/>
    <dbReference type="eggNOG" id="ENOG5030AKP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2916764_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-269-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="61" mass="6799" checksum="167C4BB00B9DEA63" modified="2011-10-19" version="1">MIKHWGKAETGMLIAAVLLLMVIFTFFEITASLTVSVIAFPISLIVLMAIMEFAATELRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT9</accession>
    <name>F9UTT9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">birA1</name>
        <name evidence="2" type="synonym">birA</name>
        <name evidence="4" type="ordered locus">lp_0337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888373.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0337"/>
    <dbReference type="EnsemblBacteria" id="CCC77859">
        <property type="protein sequence ID" value="CCC77859"/>
        <property type="gene ID" value="lp_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0337"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.287"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_1_9"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="PhylomeDB" id="F9UTT9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-281-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="77"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35318" checksum="64197D01D2A52C57" modified="2011-10-19" version="1">MTTKEQVLTILLRHHGEWQSGDQLAQSVGCSRESIWKAINALRKQGHQIESRKNRGYCYLGSRNLDAKAIQIYGQRQFTGPLEVVAQTPSTQILAKSFLSHHQPQFAAFFADEQTAGYGRLGRDFYSPAKTGLYFSLVVPNPTNALVNVGLLTTGVAVSVLNVLQQFYPNKNFGLKWVNDIYLDQHKVGGIITEASLELESISATAFIVGVGLNLTTTDFPRELQARAQAVDPSMSVDRNRLAAALLSALVALSKRYATADFLPAYRAKSLVLGQQVTLQVGDSVVNGVAEDIDEHGGLVVRMLTGERRTFTSGEVIRVGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY8</accession>
    <name>F9UTY8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641966.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0397"/>
    <dbReference type="EnsemblBacteria" id="CCC77908">
        <property type="protein sequence ID" value="CCC77908"/>
        <property type="gene ID" value="lp_0397"/>
    </dbReference>
    <dbReference type="GeneID" id="57024207"/>
    <dbReference type="KEGG" id="lpl:lp_0397"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.330"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_9"/>
    <dbReference type="OMA" id="FMLEIMP"/>
    <dbReference type="PhylomeDB" id="F9UTY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-331-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="28980" checksum="F0107DD8606EEF2D" modified="2011-10-19" version="1">MTIKLIAIDIDDTLLDSKGQLLPSTIAAVKEAHDQGIKVVLCTGRPLAGAQHYLDALGLAGDDQYVITYNGAVIESIAGRIVAKHLVDNAHYRQLTAFGKQHHVPFNVLDADSTIYTADRDVNWVTVVQAWENKAGLLIRDPDDLPADFQIAKGVFVGEGPQLDAVEAQVKTTFGRDLYVVRAATNFLELMHTGVNKGQAVQDLAAALEIQPDEVMALGDEQNDLPMFAFAGTAVAMGNGSDIAKAHADHVTATNDANGVAAAIRQWALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU14</accession>
    <name>F9UU14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein plnV,membrane-bound protease CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plnV</name>
        <name evidence="3" type="ordered locus">lp_0428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888448.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0428"/>
    <dbReference type="EnsemblBacteria" id="CCC77934">
        <property type="protein sequence ID" value="CCC77934"/>
        <property type="gene ID" value="lp_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0428"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.348"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079560_5_2_9"/>
    <dbReference type="OMA" id="DIKCSIG"/>
    <dbReference type="PhylomeDB" id="F9UU14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-355-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="25069" checksum="0818DA59C0155B34" modified="2011-12-14" version="1">MVHQNVKFISRLLLASLLAAIVMGLSTAPIDILTLKYNWITVAIFLVVYLFAIYLFYRIYLESVTNNHFKITKIAAKPSARQLVITVLAMVVMLILAAVQVKFVSDAVYSIAENVADLQALSQRSPILMALALGVFAPICEELIIRGNFFSYALAERFDQPRYQLVTVIVNGVLFGLLRGGFSWVQLSYYTVMGLVLAATYILSGRDIRVNSVVHVTANLGLMLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU73</accession>
    <name>F9UU73_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P3 protein 1, integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890889.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3390"/>
    <dbReference type="DNASU" id="1063795"/>
    <dbReference type="EnsemblBacteria" id="CCC80375">
        <property type="protein sequence ID" value="CCC80375"/>
        <property type="gene ID" value="lp_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3390"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2825"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_6_9"/>
    <dbReference type="OMA" id="CASKHEN"/>
    <dbReference type="PhylomeDB" id="F9UU73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2863-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="388" mass="45312" checksum="EF9B150454683EC4" modified="2011-10-19" version="1">MKGIINMATFKQYKTKSGAFWEAFTSVGKDTNGKAKRMHKRGFKTKKEAQLWTSNVQTDFTKNGFIANDNITFAELYTKWFNEDYKEQVKESTYMITDDIFRLHILPELGSQRVKRITVAQCQSIVHKWLNQGFKTYRRFRTYAISVFDFGVRMELTTRNPMAKTSIPKQKTKPQAPHVDFYEKSELLHFLDCASKHENPQAFMFFRLLAFTGLRRGEALALQWSDINFETNELTVNKTQAVGKRWRTIIQTPKTNTSYRTIVLDPDTAQWLHKWKMTQARQCFELGFNANDPSQLVFTNQQNKLMSPSTVNYFNWSICKKYGLRHIKIHAFRHTFCTLAFEAHAGINEVSKTLGHADLKITEQIYLHVTKKQKNETASKLARYMSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU96</accession>
    <name>F9UU96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890912.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80398">
        <property type="protein sequence ID" value="CCC80398"/>
        <property type="gene ID" value="lp_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3417"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2847"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108790_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UU96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2885-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="25796" checksum="6DC579F834345AAD" modified="2011-10-19" version="1">MPRRRNTQRRMEIVNTAFRLFAEQGYANVQMKDIAIACDISKSLLQHYFPKKIVLLSTMLNELTLSAFIYSNEQLTMLSSYQRTMIQMSFVLRMLDENPTMEHFIQDIFESPELTTEMVLVTLDWLEAIGVEGEAAMIRYALNFALSGGMAVFFKRKILRASVGMIAENIDQAFYLLLGENTEKIDQIYLSTAKYNTDYYYQQFITYLHKHATLDLSTEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU99</accession>
    <name>F9UU99_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gadB</name>
        <name evidence="8" type="ordered locus">lp_3420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU99"/>
    <dbReference type="STRING" id="220668.lp_3420"/>
    <dbReference type="EnsemblBacteria" id="CCC80401">
        <property type="protein sequence ID" value="CCC80401"/>
        <property type="gene ID" value="lp_3420"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3420"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2850"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_1_9"/>
    <dbReference type="OMA" id="TMAPHSE"/>
    <dbReference type="PhylomeDB" id="F9UU99"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2888-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="469" mass="53574" checksum="1C54E6A1BAF4C3D9" modified="2011-10-19" version="1">MAMLYGKHNHEAEEYLEPVFGAPSEQHDLPKYRLPKHSLSPREADRLVRDELLDEGNSRLNLATFCQTYMEPEAVELMKDTLAKNAIDKSEYPRTAEIENRCVNIIANLWHAPDDEHFTGTSTIGSSEACMLGGLAMKFAWRKRAQAAGLDLNAHRPNLVISAGYQVCWEKFCVYWDVDMHVVPMDEQHMALDVNHVLDYVDEYTIGIVGIMGITYTGQYDDLAALDKVVTHYNHQHPKLPVYIHVDAASGGFYTPFIEPQLIWDFRLANVVSINASGHKYGLVYPGVGWVVWRDRQFLPPELVFKVSYLGGELPTMAINFSHSAAQLIGQYYNFIRFGMDGYREIQTKTHDVARYLAAALDKVGEFKMINNGHQLPLICYQLASREDREWTLYDLSDRLLMNGWQVPTYPLPANLEQQVIQRIVVRADFGMNMAHDFMDDLTKAVHDLNHAHIVYHHDAAPKKYGFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB2</accession>
    <name>F9UUB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium transporting P-type ATPase</fullName>
            <ecNumber evidence="7">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cadA</name>
        <name evidence="7" type="ordered locus">lp_3435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890928.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3435"/>
    <dbReference type="EnsemblBacteria" id="CCC80414">
        <property type="protein sequence ID" value="CCC80414"/>
        <property type="gene ID" value="lp_3435"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3435"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2862"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_9"/>
    <dbReference type="OMA" id="IVTWLFM"/>
    <dbReference type="PhylomeDB" id="F9UUB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2902-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="634" mass="67509" checksum="C20120EE81508287" modified="2011-10-19" version="1">MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSALRNKVFSIELLVSIAVIGAFIIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMSPTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIVVEGNGYLNEASITGEARQINKQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYTPAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVVDTFAKVDTLVFDKTGTLTEGNTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYADQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLTAHNIKLNPTQLKDLNGLQAGGQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANELNLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDTSDVVLMQSSFPALVHAHGLAKKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHEASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK0</accession>
    <name>F9UUK0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transketolase</fullName>
            <ecNumber evidence="4 9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tkt4</name>
        <name evidence="11" type="ordered locus">lp_3538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="9">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102213.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891016.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUK0"/>
    <dbReference type="STRING" id="220668.lp_3538"/>
    <dbReference type="EnsemblBacteria" id="CCC80502">
        <property type="protein sequence ID" value="CCC80502"/>
        <property type="gene ID" value="lp_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3538"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2949"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_9"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="PhylomeDB" id="F9UUK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2990-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="665" mass="71951" checksum="6CCD1160917F81E6" modified="2011-10-19" version="1">MFDKVDELGVNTIRTLSIEAIQKANSGHPGLPMGAAPMAYVLWTKHLNINPKTHMNWVNRDRFILSAGHGSAMLYSLLHLAGYDVSIDDLKHFRQWDSRTPGHPEYGHTDGVEVTTGPLGQGFGMAVGMAMAEAHLAAQYNRPNFPIVDHYTYTIVGDGDLMEGISHEAGSLAGHLKLGKLIALYDSNGISLDGKTSQAFTENVGDRFTAYGWQHLVVEDGNDLDAIDAAIELAKKTTDRPSLIEVKTVIGYGAPKQGTNAVHGNPIGADGIKAAEKVYGWNYSDFEVPSAVSDRFEVTIQENGARAEQQWKRLFEEYEAKYPDQAQSFKQAFNGQFSDDLKSTLPHYQLTDALASRAASAKAINAAAKVIPSLWGGAADLSSSNKTMIAETSDFQPESYDGRNIWFGVREFGMAAAMNGIVLHGGTRVFGGTFFVFTDYLRAAVRLSALQHAPVIYVLTHDSIAVGEDGPTHEPIEQLASLRCMPNVQVIRPADGNETSAAWEQALKTTDKPTVLVLSRQALKTLPVSVDTAFAGVEKGGYVVSAAQKEIPDGLLIATGSEVNLALEAKAQLAKHNQDVAVVSIPSFDRFAQQSPEYRASVLPSAVTRRVTIEAGSTFGWDQYAGDHGAKIGVDRFGTSAPGDLVLDKYGFNVTNVVNTYLKLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O08320</accession>
    <accession>F9UL05</accession>
    <name>ARGB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">lp_0530</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642071.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888534.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08320"/>
    <dbReference type="SMR" id="O08320"/>
    <dbReference type="STRING" id="220668.lp_0530"/>
    <dbReference type="EnsemblBacteria" id="CCC78020">
        <property type="protein sequence ID" value="CCC78020"/>
        <property type="gene ID" value="lp_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="57024304"/>
    <dbReference type="KEGG" id="lpl:lp_0530"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.438"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_1_0_9"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="PhylomeDB" id="O08320"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-441-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112623" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68241." evidence="2" ref="1">
        <original>H</original>
        <variation>Q</variation>
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="248" mass="26589" checksum="D2E5AE012CF6F021" modified="2003-03-25" version="2">MTKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVNGLRVTDAATLVLTKLALLGDAQPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYVGRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADMAATVLAQQLHAEKLVLLTDVPGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGTAIIQEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE0</accession>
    <name>Q6LWE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf37</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133751.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723587"/>
    <dbReference type="EnsemblBacteria" id="CAG17868">
        <property type="protein sequence ID" value="CAG17868"/>
        <property type="gene ID" value="CAG17868"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17868"/>
    <dbReference type="eggNOG" id="ENOG5030AAH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178436_0_0_9"/>
    <dbReference type="OMA" id="NGDQHLE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3168-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="FE9065E2992095A6" modified="2004-07-05" version="1">MTKLRKENLHVTGNQEWYSLTQANHKLGRGRNYVSNWIKRHPEFPDQFLLGSGTNKLISDEGIEWVKNHIKKEGVLVSSEVANGDQHLEIRLLGVTLLIIHFTGRVRGKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE7</accession>
    <name>Q6LWE7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">orf30</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222037.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133744.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723580"/>
    <dbReference type="DNASU" id="3125602"/>
    <dbReference type="EnsemblBacteria" id="CAG17861">
        <property type="protein sequence ID" value="CAG17861"/>
        <property type="gene ID" value="CAG17861"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17861"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3108"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057848_0_0_9"/>
    <dbReference type="OMA" id="PANMGWF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3161-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008044">
        <property type="entry name" value="Phage_lysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041219">
        <property type="entry name" value="Phage_lysozyme2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05382">
        <property type="entry name" value="Amidase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18013">
        <property type="entry name" value="Phage_lysozyme2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="226"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="41630" checksum="5FF4EB13C4214B95" modified="2004-07-05" version="1">MQVLSFEYKKKKWKLIAYIVGGAILLIVLLIAAITGQLQENSCDNSTTTETQLDSKSMTENAKNIYAHWKQKYGATPQAAAGILGVLQLESRLDPNSVNSSSGATGLAQWLGGRKDKLEDLAHKENKPATNLGVQLDYLDQELNSRYYASNKQIFKYTDVHKATKAWLMDYEGMSKNPEQWYLSQRYGYADHWYSVLGASDPVAGNTLDNASSGDLTELGCDSDPSYSGGSIVKNAESMKGDFYYVQTHPSPDLGSDLKNPNKTGGTDCSGFVWLALNKAGYKAPANMGWFTGTMASDAKGSHQYLKQISENDAKAGDIVIVNQGAGAGNNGHTAILLDKWQGKATKIIEQGGVGDKVNESTFGTAFYSLLSGSDVTLARPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S55</accession>
    <name>Q88S55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator, Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891063.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3588"/>
    <dbReference type="EnsemblBacteria" id="CCC80549">
        <property type="protein sequence ID" value="CCC80549"/>
        <property type="gene ID" value="lp_3588"/>
    </dbReference>
    <dbReference type="GeneID" id="57026782"/>
    <dbReference type="GeneID" id="66451022"/>
    <dbReference type="KEGG" id="lpl:lp_3588"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2993"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_2_9"/>
    <dbReference type="OMA" id="ACWYFKS"/>
    <dbReference type="PhylomeDB" id="Q88S55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3036-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="15622" checksum="8609ABCDBDFD1589" modified="2003-06-01" version="1">MANTQLSDATHIMAYIALHTDDQLKSEHIASSLNTDPTMVRRMMSKLRKAGLLTSVRGVARPTLACSPNDITLKDIYVAVVAKRNFLNVDHNTSETCPVGSVIPRVMEKYYCDIQNSAEARMSRVTLQDIIDDISAVQQQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S87</accession>
    <accession>F9ULA7</accession>
    <name>PHK2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoketolase 2</fullName>
            <ecNumber evidence="1">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_3551</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642912.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S87"/>
    <dbReference type="SMR" id="Q88S87"/>
    <dbReference type="STRING" id="220668.lp_3551"/>
    <dbReference type="EnsemblBacteria" id="CCC80514">
        <property type="protein sequence ID" value="CCC80514"/>
        <property type="gene ID" value="lp_3551"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3551"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2961"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_9"/>
    <dbReference type="PhylomeDB" id="Q88S87"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3002-MON"/>
    <dbReference type="BRENDA" id="4.1.2.9">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q88S87"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="chain" id="PRO_0000193879" description="Probable phosphoketolase 2">
        <location>
            <begin position="1"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <sequence length="796" mass="89690" checksum="8FF214E8B88E710F" modified="2011-11-16" version="2">MSEAIKSKTVDYSSDEYLKRVDEYWRAANYISVGQLYLLNNPLLREPLKATDVKVHPIGHWGTIAGQNFIYAHLNRAINKYGLNMFYIEGPGHGGQVMVSNSYLDGTYTETYPKITQDKAGMKRLFKQFSFPGGVASHADPKTPGSIHEGGELGYSILHGAGAVLDNPGLIAATVVGDGESETGPLATSWQVNKFLNPITDGTVLPILNLNGFKISNPTVLSRESHEELEDYFKGLGWDPHFVEGTDPAKMHKIMAEELDKVIEEIHAIRKNAKDNNDESRPKWPMIVFRAPKGWTGPKSWDGEPIEGSFRAHQIPIPVDRNHMEHADKLVDWLKSYKPEELFDENGTLKPEIAAIIPEGQARMAANPVTNGGKLTKDLITPNIDDYALDNKSHGKEDGSDMTELGKYIRDLIELNKDNKNFRGWGPDETLSNKLGAAFEDTKRQWMEPIHEPNDALLAPQGRIIDSMLSEHMDEGMLEAYNLTGRYGFFASYESFLRVVDSMLTQHFKWLRNSHEETPWRADVPSLNVIASSTAFQQDHNGYSHQDPGIISHLAEKKTEYVRAYLPGDANTLIATFDKAIQSKQLINLIIASKHPRPQWFTMDEAKRLVRDGLGVVDWASTDHGEEPDVVFATAGSEPTTESLAAVSILHARFPEMKIRFINVVDLLKLKKDDPRGLSDAEFDAFFTKDKPVIFAYHAYDDLVKTIFFDRHNHNLHVHGYREEGDITTPFDMRVRNELDRFHLVKAALLATPAYAEKGAHVIQEMNSILDKHHDYIRAEGTDIPEVENWKWTALK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SV5</accession>
    <accession>F9UTG4</accession>
    <name>GUAC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="1">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaC</name>
        <name type="ordered locus">lp_3271</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SV5"/>
    <dbReference type="SMR" id="Q88SV5"/>
    <dbReference type="STRING" id="220668.lp_3271"/>
    <dbReference type="EnsemblBacteria" id="CCC80282">
        <property type="protein sequence ID" value="CCC80282"/>
        <property type="gene ID" value="lp_3271"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3271"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2731"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_0_9"/>
    <dbReference type="OMA" id="AYKEYFG"/>
    <dbReference type="PhylomeDB" id="Q88SV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2770-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01511">
        <property type="entry name" value="GMP_reduct_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005994">
        <property type="entry name" value="GuaC_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036500">
        <property type="entry name" value="GMP_red_Firmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01306">
        <property type="entry name" value="GMP_reduct_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000093760" description="GMP reductase">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01511"/>
        </source>
    </evidence>
    <sequence length="325" mass="35432" checksum="E19846BECA12DBE6" modified="2003-06-01" version="1">MGMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLATNDYFYIMHRFAPETRRAFIETMHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDIAHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLENAGADATKVGVGPGKACITKVKTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQESPGNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISYAGGRDLKAITKCDYVVVKNSIYNGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U24</accession>
    <accession>F9URK1</accession>
    <name>PURQ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name type="ordered locus">lp_2725</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101895.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U24"/>
    <dbReference type="SMR" id="Q88U24"/>
    <dbReference type="STRING" id="220668.lp_2725"/>
    <dbReference type="EnsemblBacteria" id="CCC79840">
        <property type="protein sequence ID" value="CCC79840"/>
        <property type="gene ID" value="lp_2725"/>
    </dbReference>
    <dbReference type="GeneID" id="57026100"/>
    <dbReference type="KEGG" id="lpl:lp_2725"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2280"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_9"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="PhylomeDB" id="Q88U24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2331-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100562" description="Phosphoribosylformylglycinamidine synthase subunit PurQ">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <sequence length="226" mass="23894" checksum="1C20BB891664CEB6" modified="2011-11-16" version="3">MMKFAVPVFPGSNCDHDMVNALRDILHVTADLIPATATSLAGYDAVVLPGGFSYGDYLRSGAIARFAPIMPAVIAFANAGKPVIGICNGFQVLTEAGLLPGALQANRSAKFICQDSPLRIANHETIFTTAYGSTDQISLPIAHGEGNYYCDEATLAQLRANHQIIFEYVENPNGSTANIAGITNEAGNVLGMMPHPERAVEMILGSTDGLGIFQSVIASQEEVTHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UZ5</accession>
    <accession>F9UQL1</accession>
    <name>RNY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Y</fullName>
            <shortName evidence="1">RNase Y</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rny</name>
        <name type="ordered locus">lp_2300</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890014.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UZ5"/>
    <dbReference type="STRING" id="220668.lp_2300"/>
    <dbReference type="EnsemblBacteria" id="CCC79500">
        <property type="protein sequence ID" value="CCC79500"/>
        <property type="gene ID" value="lp_2300"/>
    </dbReference>
    <dbReference type="GeneID" id="57025836"/>
    <dbReference type="KEGG" id="lpl:lp_2300"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1944"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_9"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="PhylomeDB" id="Q88UZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1984-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000163777" description="Ribonuclease Y">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="519" mass="58162" checksum="6B800CB584F3D62B" modified="2003-06-20" version="1">MNVFGIILAVIAIVVGYGIGYYVRKNVHEKELDVARNTAEGIISEAKRAAETHKKEKVLEAKEESHRYRAEVETELKQRRNEVQKQEDRLLQREETLDHKENTFEKREDALGKKEDKIANEQKRVEQQQQSAASLITQRQAELERVAALSQEQARDQILTQTREQLTHERAVLIKENTDEVKAQSEKEAKNLIVQAIQQSAADMVSETTVSVVSLPNDDMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGYDPIRREIAKIALEKLIQDGRIHPARIEEMVEKARKEMDEKIRETGEQAVFDLGLHGMHPDLIKLVGRLNYRTSYGQNVLNHSIEVAKLAGVLAAELGEDVTLAKRAGLLHDIGKAVDHEVEGSHVEIGVELTTKYKESPVVINTIASHHGDVEAKSIIAVLVATSDSISAARPGARSESLENYIHRLEKLEAIANNEDGVKKSYAIQAGREIRVIVKPNEISDLQATVLAHDVKKQIENELEYPGHIKVTVIREVRAVDYAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-29" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V72</accession>
    <accession>F9UQD5</accession>
    <name>FTSK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>DNA translocase FtsK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ftsK</name>
        <name type="ordered locus">lp_2210</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Located at the septum.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889938.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V72"/>
    <dbReference type="SMR" id="Q88V72"/>
    <dbReference type="STRING" id="220668.lp_2210"/>
    <dbReference type="EnsemblBacteria" id="CCC79424">
        <property type="protein sequence ID" value="CCC79424"/>
        <property type="gene ID" value="lp_2210"/>
    </dbReference>
    <dbReference type="GeneID" id="57025734"/>
    <dbReference type="KEGG" id="lpl:lp_2210"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1866"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_6_9"/>
    <dbReference type="PhylomeDB" id="Q88V72"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1885-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000098265" description="DNA translocase FtsK">
        <location>
            <begin position="1"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="181"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="468"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="795" mass="86622" checksum="2167BB4E1D9E9664" modified="2011-11-16" version="2">MARRQATTKKRRTSTRKKKPTVAAKRQMTGNVIGLIGLLVTILALLKVGLVGMVFAEFFRAIAGNAYQIFAGLTLLVMGYLMIFGRWPRLTWRWWVGGNLFFFSYLLLLEIPMFNQLNHHTDFWSLTWNLIKNDFAKGGMASNLGGGLVGAAGYSVTYPLLANVGTILIALILMVASIYITFDLPFHKTMQALRQALMQLGQQLRSGYEWLTHVLRVQIARWRVHQQVRANQAASTEKQPTSTVPQSAAPAETTSGTSAPDSAASAVTSSPADLNITVASDREASPIKSPTSAATVDHEQELQGTEVMDDADYQLPESTLLTKIPKTDQSAEYATIESNSQKLTTTLASFGVQVEVKNVSLGPSVTKYELHPAVGVKVSKVVNLADDLALALAAKDLRIEAPIPGKSLIGIEVPNKQISTVSFRDIVEAQPAHPTKPLAVPLGRDVSGNLVVADLSKMPHLLIAGSTGSGKSVAINVMITGLLMNTKPSQVKFMLIDPKKVELGVYNGIPHLLTPVVTEPKKAARALHKVVAEMERRYELFADSKQRNMQGYNQYIRQQNAADGQSRPVLPYIVVVVDELADLMMVTSSEVEDAIIRLGQMARAAGIHMILATQRPSVDVITGLIKANVPSRMAFAVSSGTDSRTIIDSNGAEKLLGRGDMLYQPMGMNKPLRVQGAYISDHDVEEVVNFIKAQQTADYDDSMLVKDDETDAAGSGDPRDGEDEYYAEAVELVTDQQSASVSMLQRRFRIGYNRAARIVDEMEERGVVGPSEGSKPRKVYRQKSADEAPASGNDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VS1</accession>
    <accession>F9UPT1</accession>
    <name>RECO_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name type="ordered locus">lp_1966</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644472.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889734.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VS1"/>
    <dbReference type="SMR" id="Q88VS1"/>
    <dbReference type="STRING" id="220668.lp_1966"/>
    <dbReference type="EnsemblBacteria" id="CCC79220">
        <property type="protein sequence ID" value="CCC79220"/>
        <property type="gene ID" value="lp_1966"/>
    </dbReference>
    <dbReference type="GeneID" id="57025545"/>
    <dbReference type="GeneID" id="66449772"/>
    <dbReference type="KEGG" id="lpl:lp_1966"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1660"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_4_0_9"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="PhylomeDB" id="Q88VS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1684-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000204963" description="DNA repair protein RecO">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <sequence length="258" mass="29780" checksum="0C5366C3D2C93D46" modified="2003-06-01" version="1">MVTNFNGILLFRRDYRERDMLIKFLTAEYGKKMFFIRGARRRGFKMAAELLPFTMGEYVGDLRDQGLSYINSVKSVQYLEHISQDIALNAYATYVMNLMDVAFPDNQPVGRWYQQLTSALQLIDQDVAPALVANVVEIQLLQPFGVAPELRWCTVCGRSDLPLDYSESYGGLLCQQHWHLDPHRLHASPAAIFYLRQFSVLDLAKVHSIKVKPRTAAELRRILDEIYQNSVGVRLKSKRFIDQMGSWYQPLAPRKNED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WI2</accession>
    <accession>F9UP21</accession>
    <name>TRPC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="1">IGPS</shortName>
            <ecNumber evidence="1">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpC</name>
        <name type="ordered locus">lp_1655</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889474.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WI2"/>
    <dbReference type="SMR" id="Q88WI2"/>
    <dbReference type="STRING" id="220668.lp_1655"/>
    <dbReference type="EnsemblBacteria" id="CCC78960">
        <property type="protein sequence ID" value="CCC78960"/>
        <property type="gene ID" value="lp_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1655"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1396"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_9"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="PhylomeDB" id="Q88WI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1423-MON"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154226" description="Indole-3-glycerol phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <sequence length="260" mass="27912" checksum="C2A7C978EA22B407" modified="2003-06-01" version="1">MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPSKGLIAAEFDYLQIAQDYVAAGIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVAASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLSALVEVHTTAESKQAVAAGARIIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGETLMRAPDKGQAVMQLRAGVRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WR8</accession>
    <accession>F9UNT3</accession>
    <name>YIDC1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC1</name>
        <name type="ordered locus">lp_1553</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889386.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WR8"/>
    <dbReference type="SMR" id="Q88WR8"/>
    <dbReference type="STRING" id="220668.lp_1553"/>
    <dbReference type="EnsemblBacteria" id="CCC78872">
        <property type="protein sequence ID" value="CCC78872"/>
        <property type="gene ID" value="lp_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1553"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1306"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_5_1_9"/>
    <dbReference type="OMA" id="GWAIIII"/>
    <dbReference type="PhylomeDB" id="Q88WR8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1333-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01811">
        <property type="entry name" value="YidC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023060">
        <property type="entry name" value="YidC/YidC1/YidC2_Firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000020384" description="Membrane protein insertase YidC 1">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="307" mass="34248" checksum="B425049E09D49154" modified="2003-06-01" version="1" precursor="true">MKSKKGLTLTITLGTLALFLSGCVQTTKAGKPYGFVYEYLAKPGQNVMEWLSQLFGNNYGWAIIGLTVIVRLVLLPMMINQQRKSTYQQEKMSAVRPQMEKIQARQKAATTQEEKAAISNELMQLYRDNGISMTGGIGCLPLLIQLPIFSALYYAIRYSPELSKATFMGISLGKSSLILAILAFLSYLAQGYLSMIGLPEEQKKTMRLMLIMSPVMILFVSMSAPAGLGLYFFVGGLFACLQTLIINFFRPRIRREVEAELKKHPIKTPTPTQPKPINATESKPSHPRPQNNAGRGRNAGKQQRHHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XG5</accession>
    <accession>F9UN33</accession>
    <name>RECX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recX</name>
        <name type="ordered locus">lp_1240</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XG5"/>
    <dbReference type="SMR" id="Q88XG5"/>
    <dbReference type="STRING" id="220668.lp_1240"/>
    <dbReference type="EnsemblBacteria" id="CCC78622">
        <property type="protein sequence ID" value="CCC78622"/>
        <property type="gene ID" value="lp_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1240"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1052"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_4_0_9"/>
    <dbReference type="PhylomeDB" id="Q88XG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1063-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000162440" description="Regulatory protein RecX">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <sequence length="267" mass="31121" checksum="BFE680E93A5B2A35" modified="2011-11-16" version="2">MTKKVTKIVAQKRAGRYNIYLDEQYAFPISESVMIKFRVFKGMEVDEQLQAAMIAADDVSKAYTRALDYLSHQLRTEKEVHDKLRDEEIDESVIDATMQQLRDMRLLNDQQYADAFVRTAKRTSDKGPRVIRQNLRQKGVGEQLIDDALAGQFSAEEQIDNASELARKLAKRYHRQAFKTMQQKVRQGMMTKGFDNDTITAAIASLALEPDEDEQWEALVAQGTKLWQRNRKYAFRERMMRTKRSLFQKGFMMDDINRFIDEQVADE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XP8</accession>
    <accession>F9UMU8</accession>
    <name>GATC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name type="ordered locus">lp_1147</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641341.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889051.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XP8"/>
    <dbReference type="SMR" id="Q88XP8"/>
    <dbReference type="STRING" id="220668.lp_1147"/>
    <dbReference type="EnsemblBacteria" id="CCC78537">
        <property type="protein sequence ID" value="CCC78537"/>
        <property type="gene ID" value="lp_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="57024783"/>
    <dbReference type="GeneID" id="66449036"/>
    <dbReference type="KEGG" id="lpl:lp_1147"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.968"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_1_2_9"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="PhylomeDB" id="Q88XP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-979-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105304" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <sequence length="106" mass="11566" checksum="6CA7AF43ED754ED9" modified="2003-06-01" version="1">MAEERINAEQVQHVASLAKLEFTPDQLAMFTPQLEKIIGMFEELSTVDTTGVPVTSRMSDHTNTLREDVAVKSDEALREALLKNAPETANGLIKVPAIIDESGDGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XV9</accession>
    <accession>F9UMN2</accession>
    <name>RL17_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">lp_1063</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XV9"/>
    <dbReference type="SMR" id="Q88XV9"/>
    <dbReference type="STRING" id="220668.lp_1063"/>
    <dbReference type="EnsemblBacteria" id="CCC78471">
        <property type="protein sequence ID" value="CCC78471"/>
        <property type="gene ID" value="lp_1063"/>
    </dbReference>
    <dbReference type="GeneID" id="57024718"/>
    <dbReference type="KEGG" id="lpl:lp_1063"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.898"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_2_9"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="PhylomeDB" id="Q88XV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-914-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000055856" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <sequence length="127" mass="14166" checksum="57317009363CF31F" modified="2003-06-01" version="1">MSYRKLQRTSSQRRALLRDLTTSLIVNGKIETTEARAKEVRSTADKMISLAKKGDLSARRKAAAFMRDVVADVKEDGDNVAVQTALQKLFSDLGPQYADRNGGYTRIYKTMPRRGDGAQMVVLELVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX0</accession>
    <accession>F9UMM1</accession>
    <name>RL18_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">lp_1052</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888974.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX0"/>
    <dbReference type="SMR" id="Q88XX0"/>
    <dbReference type="STRING" id="220668.lp_1052"/>
    <dbReference type="EnsemblBacteria" id="CCC78460">
        <property type="protein sequence ID" value="CCC78460"/>
        <property type="gene ID" value="lp_1052"/>
    </dbReference>
    <dbReference type="GeneID" id="57024707"/>
    <dbReference type="GeneID" id="66448963"/>
    <dbReference type="KEGG" id="lpl:lp_1052"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.887"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_9"/>
    <dbReference type="PhylomeDB" id="Q88XX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-903-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131280" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="118" mass="13041" checksum="8E455E9922CFFA43" modified="2011-11-16" version="2">MISKPDKNKTRQRRHARVRGKISGTAERPRLNVYRSNKNIYAQVIDDVEGVTLASASTLDSEVKGNNKTEKAASVGEVVAKRAAEKKIVDVVFDRGGYLYHGRVQALAEAARENGLKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y23</accession>
    <accession>F9UMG9</accession>
    <name>MURE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="1">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name type="ordered locus">lp_0977</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101237.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y23"/>
    <dbReference type="SMR" id="Q88Y23"/>
    <dbReference type="STRING" id="220668.lp_0977"/>
    <dbReference type="EnsemblBacteria" id="CCC78408">
        <property type="protein sequence ID" value="CCC78408"/>
        <property type="gene ID" value="lp_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="57024649"/>
    <dbReference type="KEGG" id="lpl:lp_0977"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.831"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_9"/>
    <dbReference type="PhylomeDB" id="Q88Y23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-844-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101905" description="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <sequence length="493" mass="53810" checksum="456B7CA6F143C2AE" modified="2004-04-26" version="2">MQASQLINSLKFKQVQPALTTDFDVTMLTQDTREVQPGAMFIAVVGYHVDGHDLVDQAIEKGAKIIVASKPLDVNVPVIYVENTERAMAILADVFYGAPSQKMRMIGVTGTNGKTTVTHLIEQIYRDQQQATGLIGTMYRKIKDEKLPTANTTPDAITTQRTLAAMRDAGVETVAMEVSSIALVLGRVWGIDYDIAVFTNLTQDHLDFHKTMAKYTEAKAMLFAQLGNKYSADGTNKVAVLNTDDPVGREFEQYTAAHVLTFGLKPDAMINAQNVEIKSHGTEFDLSVFGHVTHVTMQLIGQFNVYNMLAAFAAAYASGIPEDQIIKSLEKVTGVKGRFQSVPSHTGVSVIVDYSHTPDGLLNALETIQDFATKDIYCVVGCGGDRDKTKRPKMAKIAVEHSTKPIFTSDNPRTEDPTMILNDMVAGVPNADVPVYEDRHVAIAKAIEAAQPGDVVLIAGKGHEDYQIIGRTKHHFDDSEEAAKALALKPTID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YG7</accession>
    <accession>F9UM20</accession>
    <name>SSRP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">lp_0799</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888773.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YG7"/>
    <dbReference type="SMR" id="Q88YG7"/>
    <dbReference type="STRING" id="220668.lp_0799"/>
    <dbReference type="PRIDE" id="Q88YG7"/>
    <dbReference type="EnsemblBacteria" id="CCC78259">
        <property type="protein sequence ID" value="CCC78259"/>
        <property type="gene ID" value="lp_0799"/>
    </dbReference>
    <dbReference type="GeneID" id="57024500"/>
    <dbReference type="GeneID" id="66448762"/>
    <dbReference type="KEGG" id="lpl:lp_0799"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.676"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_9"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="PhylomeDB" id="Q88YG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-695-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000102966" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <sequence length="156" mass="18071" checksum="08A2B4F70D52C614" modified="2003-06-01" version="1">MAKQHGKHPDTALAQNRKARHDYAVEETYEAGIALTGTEIKSVRDRRVNLKDGFVQVRNGEAWMQNVHISPFKEGNRYNVDPLRSRKLLLHKKEISKLGAATMTKGVTIIPLKMYLKHGFAKVLIGVAHGKREYDKRQDIKKREQQRQIDRVMKHY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-09" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YK7</accession>
    <accession>F9ULX7</accession>
    <name>PSTB2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB 2</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB2</name>
        <name type="ordered locus">lp_0750</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888730.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YK7"/>
    <dbReference type="SMR" id="Q88YK7"/>
    <dbReference type="STRING" id="220668.lp_0750"/>
    <dbReference type="EnsemblBacteria" id="CCC78216">
        <property type="protein sequence ID" value="CCC78216"/>
        <property type="gene ID" value="lp_0750"/>
    </dbReference>
    <dbReference type="GeneID" id="57024450"/>
    <dbReference type="KEGG" id="lpl:lp_0750"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.631"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="VKHALQG"/>
    <dbReference type="PhylomeDB" id="Q88YK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-651-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092827" description="Phosphate import ATP-binding protein PstB 2">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28054" checksum="FF519D94CDC84C45" modified="2003-06-01" version="1">MSTILTTENLSLFYGKKEALKGINIDFDDKGITALIGPSGCGKSTFLRCLNRMNDLIPNVTITGEVNFNGHNIYAPTTDTVQLRKEIGMVFQQPNPFPFSIYENVIYGLRLAGVHDKERLDAAVEKSLKQAAIWDEVKDRLHANALSLSGGQQQRVCIARVLAVEPDIILLDEATSALDPISSRMIEETLLNLRQDYTIITVTHNMQQASRISDRTAFFLNGELIEVNDTKQIFMNPVKQETNDYISGRFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YM6</accession>
    <accession>F9ULV8</accession>
    <name>CH10_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">lp_0727</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888711.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YM6"/>
    <dbReference type="SMR" id="Q88YM6"/>
    <dbReference type="STRING" id="220668.lp_0727"/>
    <dbReference type="EnsemblBacteria" id="CCC78197">
        <property type="protein sequence ID" value="CCC78197"/>
        <property type="gene ID" value="lp_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="57024432"/>
    <dbReference type="GeneID" id="66448700"/>
    <dbReference type="KEGG" id="lpl:lp_0727"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.612"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_1_9"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="PhylomeDB" id="Q88YM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-632-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000174772" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <sequence length="94" mass="10293" checksum="20002D1DF85EDE0B" modified="2003-06-01" version="1">MLKPLGDRVILQQQEEEEQTIGGIVIANNAKEKPQSGKVVAVNDGRVLDNGTKVDPSVKVGDQVLFDKYAGTEVKYQGAKYLVLHEKDIVAIED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z30</accession>
    <accession>F9UL21</accession>
    <name>HSLO_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 33 homolog</fullName>
            <shortName evidence="1">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslO</name>
        <name type="ordered locus">lp_0548</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888550.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z30"/>
    <dbReference type="SMR" id="Q88Z30"/>
    <dbReference type="STRING" id="220668.lp_0548"/>
    <dbReference type="EnsemblBacteria" id="CCC78036">
        <property type="protein sequence ID" value="CCC78036"/>
        <property type="gene ID" value="lp_0548"/>
    </dbReference>
    <dbReference type="GeneID" id="57024322"/>
    <dbReference type="KEGG" id="lpl:lp_0548"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.454"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_9"/>
    <dbReference type="OMA" id="DMQCECC"/>
    <dbReference type="PhylomeDB" id="Q88Z30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-457-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000192182" description="33 kDa chaperonin">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <sequence length="295" mass="31472" checksum="8C9C8153B97692FB" modified="2003-06-20" version="1">MADYLVKSVAGNEMFRAYAVSATGVVAEAQRRHDTWSAASAALGRSLVGTLLLASSVLKGEEQMTVKINGNGPVGGIVVDGNAKGTVKGYLQHPHVHLPLNDKHKIDVKAAVGTDGFLSVTKDQGVGDPFTGTVALVSGELGEDFTYYLAQSEQIPSAVGLSVFVNDDNSIGVAGGFLVQVLPNATDEAISSLENKLKDMPLVSQLMRDGKSPEDILDLLFDGDVKVLDKMPVKFECDCSKERFAEALMALPKHEVQAMIDEDHGATAVCHFCGDQYQFSERELEAVLSRSKGDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z77</accession>
    <accession>F9UKW2</accession>
    <name>RPOE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable DNA-directed RNA polymerase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNAP delta factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoE</name>
        <name type="ordered locus">lp_0480</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RpoE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z77"/>
    <dbReference type="SMR" id="Q88Z77"/>
    <dbReference type="STRING" id="220668.lp_0480"/>
    <dbReference type="EnsemblBacteria" id="CCC77977">
        <property type="protein sequence ID" value="CCC77977"/>
        <property type="gene ID" value="lp_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0480"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.394"/>
    <dbReference type="eggNOG" id="COG3343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116648_0_0_9"/>
    <dbReference type="OMA" id="TWGLRSW"/>
    <dbReference type="PhylomeDB" id="Q88Z77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-398-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00357">
        <property type="entry name" value="RNApol_bact_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038087">
        <property type="entry name" value="RNAP_delta_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029757">
        <property type="entry name" value="RpoE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04567">
        <property type="entry name" value="RNAP_delt_lowGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000204314" description="Probable DNA-directed RNA polymerase subunit delta">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="199" mass="22479" checksum="4C44258E3710434D" modified="2003-06-01" version="1">MELKQFDGQKKSELSLIEVAHAILSQHGDVMAFADLTNAVQSYLGKSDEEIRERLSQFYTDLNIDGSFISLGDNMWGLRAWYPFESIDEAVIHTDDDEDEDRPKRKKVNAFLADAGDDDDVIDYDDDDPEDDDNYDDDDDQDDDTDDSASSKYDELAGVDDTDDDVADETLPDGIEGQLSELNDDDDDDDYDDEDDESK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-03" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z84</accession>
    <accession>F9UKV5</accession>
    <name>KPRS1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate pyrophosphokinase 1</fullName>
            <shortName evidence="1">RPPK 1</shortName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-phospho-D-ribosyl alpha-1-diphosphate 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl diphosphate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl pyrophosphate synthase 1</fullName>
            <shortName evidence="1">P-Rib-PP synthase 1</shortName>
            <shortName evidence="1">PRPP synthase 1</shortName>
            <shortName evidence="1">PRPPase 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prs1</name>
        <name type="ordered locus">lp_0471</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888484.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z84"/>
    <dbReference type="SMR" id="Q88Z84"/>
    <dbReference type="STRING" id="220668.lp_0471"/>
    <dbReference type="EnsemblBacteria" id="CCC77970">
        <property type="protein sequence ID" value="CCC77970"/>
        <property type="gene ID" value="lp_0471"/>
    </dbReference>
    <dbReference type="GeneID" id="57024268"/>
    <dbReference type="GeneID" id="66448543"/>
    <dbReference type="KEGG" id="lpl:lp_0471"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.387"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_0_9"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="PhylomeDB" id="Q88Z84"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-391-MON"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000141148" description="Ribose-phosphate pyrophosphokinase 1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <sequence length="326" mass="35880" checksum="28AC04BEAADCD656" modified="2003-06-01" version="1">MSEQYFDPKLKIFALNSNKPLAEKIADAVGVKLGKTSVDRFSDGEIRINIEESIRGDQVYIIQSTSAPVNDNLMELLIMIDALRRASAKTINVVIPYYGYARQDRKARSREPITAKLVANMLETAGATRILALDLHAAQIQGFFDIPLDHLMGAPLLADYFLNHHLDENAVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGDVKGKRAIMIDDMIDTAGTITLGAQALVDAGATEVYASCTHPVLSGPAIERIEKSPIKKLVVTDSIELPAAKRIDKIEQVSVGQLMGQAIKFIHENKPVSPLFKNRFHNEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV8</accession>
    <name>F9UKV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888487.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0475"/>
    <dbReference type="EnsemblBacteria" id="CCC77973">
        <property type="protein sequence ID" value="CCC77973"/>
        <property type="gene ID" value="lp_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0475"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.390"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_1_9"/>
    <dbReference type="OMA" id="GAWIQDP"/>
    <dbReference type="PhylomeDB" id="F9UKV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-394-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="269" mass="29376" checksum="032F19BA98EA2DA3" modified="2011-10-19" version="1">MSVKLIAIDMDGTLLNEHSELNPATVQAINAANAQGIKVVICTGRPLSGVTPFLKQLGIAGEDNYVITFNGSMVQTITGKIITGLTLSHDDYIDIETLSRKLNIHCHVESEDHIYTANRNISPYTVGESALVNMPIRFRTPEEMRPDLPIVKCMFIDHAPLLDAAIKQLPASFSKRFTIVRSEAYFLEFMNPAASKGNALATLTDHLNLTADEVMAIGDQGNDLSMLRYATNSVAMGNAIDEAKQIARYETKTNVEDGVAHAINTWALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA4</accession>
    <name>F9ULA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 18, DNA single-strand annealing protein RecT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888633.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0641"/>
    <dbReference type="EnsemblBacteria" id="CCC78119">
        <property type="protein sequence ID" value="CCC78119"/>
        <property type="gene ID" value="lp_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0641"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.535"/>
    <dbReference type="eggNOG" id="COG3723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072032_0_0_9"/>
    <dbReference type="OMA" id="SWSHAKT"/>
    <dbReference type="PhylomeDB" id="F9ULA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-552-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004590">
        <property type="entry name" value="ssDNA_annealing_RecT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00616">
        <property type="entry name" value="rect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="32803" checksum="B66E84BB4ADD5434" modified="2011-10-19" version="1">MSNELVTMVNNNIEDMKNNEGLSLPPDYSVGNALNSAYLILSDTSKGQPLLDKCDQGSVIKALMNMAIQGLSPAKNQCYFIPYGNQLVMQRSYFGSISVVKRLSNVKDIQAQVVHKDDTFKIGGKDGVLVVKEFEPSFENLDKPIIGAFAWIEDINGNRTYTVMTKKDIDISWSHAKTKKVQNEFPEEMAKRTVINRAAKFYINSSSDNDLFVKAVNETTSNEYENDERKDVTPAKRSLVADVAENKAEKVESAEPAKEPVRTAVKEASSNDQEPVKGEVDQQNLFDNLGDFDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF9</accession>
    <name>F9ULF9_LACPL</name>
    <protein>
        <submittedName>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
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                <person name="Sandbrink H.M."/>
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                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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        <citation type="submission" date="2008-02" db="PDB data bank">
            <title>Crystal structure of myo-inositol 2-dehydrogenase (NP_786804.1) from Lactobacillus plantarum at 2.40 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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                <person name="Boekhorst J."/>
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                <person name="Tarchini R."/>
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                <person name="Nierop Groot M.N."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101150.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888726.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0746"/>
    <dbReference type="EnsemblBacteria" id="CCC78212">
        <property type="protein sequence ID" value="CCC78212"/>
        <property type="gene ID" value="lp_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0746"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.627"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_0_9"/>
    <dbReference type="OMA" id="RHWDELK"/>
    <dbReference type="PhylomeDB" id="F9ULX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-647-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="13">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="291" mass="31528" checksum="9587CB29D78E67DE" modified="2011-10-19" version="1">MRKSRVIQLIVLIAIIGLVGLGYTHRDRTSASESITAVGSTALQPLVEAAGEQYSSNHTGVFINVQGGGSGTGLSQIQAGAVAIGNSDIFAEEQSGITASKLIDHRVAVVGIAPIVNKKAGITNLTQQQLIQIFTGKVTNWREVGGRNLPITLINRAQGSGTRKTFERYALKGNQSVDSQEQDSSGLARSIVASTPGAISYVAFSYLDNSVQTVNVDGIRPTEKNVRNNRWYIWSYEHLYTGKHPNQLTKKFIDYILSTAVQQKLVKQLGYISVHDMQVQRNAAGKVSVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM55</accession>
    <name>F9UM55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multi drug transporter, major facilitator superfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101177.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888808.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0840"/>
    <dbReference type="EnsemblBacteria" id="CCC78294">
        <property type="protein sequence ID" value="CCC78294"/>
        <property type="gene ID" value="lp_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0840"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.714"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_9"/>
    <dbReference type="PhylomeDB" id="F9UM55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-730-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="477" mass="51228" checksum="79934BDB145EA715" modified="2011-10-19" version="1">MSTTTPVIPTQTKVAIFGTASLAFCGILVETSMNVTFPTLMHQFHTTLATVQWVTTAYLLAVAATMVITAFIQQRFRWRTIINVGGAGFVLGGLLCTVAPQLWLLLFGRIIQAIGTGLALPLVFAQIMTQVPFTAQGRFTGTAGMLIALAPSLGPTYGGLVTQLLSWRLIFGITLPFGLIAWLITAKTIRQTQAPRSRPFPLCQFGLVVAALILLIFSVNNLSTHGLSLVFVWLPLLLAVLAVLTFTRSATRTTHPLINLAVFQQGDFTRALLIYFFIQFIQIGLTFLLPNFAQLALGKNALVSGLMLLAGSLCSAILSPLAGKLMDRRGIRRPFQIGSGFLLLATLSLAGLAQHLSVGLIIGLFVGFQIGFSCLFNNALTYGLQQLPPQLMGDGNALFNTLQQYSGSLGTAIMAVLITLGTRMAPSASSTMQTTLGTQIALWFSLIIIMIVAALALTTKPIANMADDQHQSRSSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG1</accession>
    <name>F9UMG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
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                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="333" mass="37801" checksum="C9175ACD4E2EDA0A" modified="2011-10-19" version="1">MQVFGQFIATVGWLGLALVASELGATLIHWLGQWVGFRLIGARIVRITGFRLQLSRVRGHWKLERPLTRHPHIVAAPSADAKRFNHAIYCFGGGLFNLLTVMLSLITLNQFKFSFDLWLFAFIIWIWVNTLKAAQLLPMNLHGYPTAGQEFRQARESTAAMTAAYVTACAAAVKVQTGSVRDLDASMIVMPRDGGNRNYLVVRQAWLILEWGLQHGLDTPELLAGLSRLEPSFNTLPPADLAKYLDATLYWNLVTNHRDPQIIAWYQDDGVQQLLRRYQPLAHYKLTAVYEWRVHQQPEQALALIEKGLKIAQRLHDEEEIAWLKALRVQVTA</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888927.1">
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    <dbReference type="EnsemblBacteria" id="CCC78413">
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        <property type="gene ID" value="lp_0984"/>
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    <dbReference type="GeneID" id="66448908"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
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            <dbReference type="Pfam" id="PF13411"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC78413.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="72" mass="7836" checksum="0CBE738BC466FC92" modified="2011-10-19" version="1">MTLEQLAAHSGVAADKIVAYTNAGLLPCKDVNAHFSADDEYWLDMVNCFLENGSSVEDLKDLMPLCEQCAAQ</sequence>
</entry>
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    <accession>F9UMW6</accession>
    <name>F9UMW6_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC78555">
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    <dbReference type="KEGG" id="lpl:lp_1165a"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394388" evidence="2">
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            <end position="66"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78555.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7389" checksum="23151805BBE0E564" modified="2011-10-19" version="1">MSIHRGLPVLVILAVCGGLLTLPATNAQALRVRGTRVTMRVKHRAKPSKHHYSKRSARSHNARHHH</sequence>
</entry>
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    <accession>F9UMX0</accession>
    <name>F9UMX0_LACPL</name>
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    <gene>
        <name evidence="2" type="primary">pbpX1</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.16.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101277.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1171"/>
    <dbReference type="MEROPS" id="S12.A21"/>
    <dbReference type="EnsemblBacteria" id="CCC78559">
        <property type="protein sequence ID" value="CCC78559"/>
        <property type="gene ID" value="lp_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1171"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.990"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_3_1_9"/>
    <dbReference type="OMA" id="WWKGYNT"/>
    <dbReference type="PhylomeDB" id="F9UMX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1002-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="43131" checksum="451E34720C87906E" modified="2011-10-19" version="1">MMNKRRWLLSLLPILLGLIGVGVWGSQQLGQGAQQVTPKTIKVQQAASKIKSATKKQTTTKPKVKPGQLTEAQAIKQIDQLIKSHHIMGTLLLTTNGPAGVRVRTYGYADDANQVRNTATEAYPLASLQKAVTGVMVQKLINQGKLSLTTKLSHFYPEIPYANQITIRELLDHRSGIRMTEITPKTILPTETARLNFTLQHLRSTNNHAYAYSNANFTLLAGVIRKVTHKSYQAALTNDIIRPLGLKHTYEYNDIPGNVINPTSYRLANGFGQSGIISKPLQSSELGCGSLYMSVGDYYKFMYGLQSGQLVGEAGLKSLADNFQIKYSAGVYYQAGQLIRVGGNDNNFHSYYMGSRNAKVALVLFENQGVFGGDNQVAYKIRDILLKTVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX6</accession>
    <name>F9UMX6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps1B</name>
        <name evidence="2" type="ordered locus">lp_1178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101281.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1178"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78565">
        <property type="protein sequence ID" value="CCC78565"/>
        <property type="gene ID" value="lp_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1178"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.996"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_43_0_9"/>
    <dbReference type="OMA" id="ATWWETA"/>
    <dbReference type="PhylomeDB" id="F9UMX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1008-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="40208" checksum="444061929C466F64" modified="2011-10-19" version="1">MKITFILPGFTRFPVGGYQIVYQYAGYLSSKGYDVEIIHAMFLPTQEKPGIKKKIIYSVKSFLFALHLIRPWFQIDSRIKVLNKGKILTKDVRKADRVIATAWETSEFVSLLPSECGEKYYFIQHYETWGGKERVDKTWKLPLKKIVIASWLKKIASEMQEEAVLVPNFVEQNNFFVTKPIKDRTPTISMLYSEHEIKGSNLGIQVLKMLKNKYPNVHIKLFGVFEKPDNLPEGTMYYQNPSRKVLRDEIYNESSVYLFPSVSEGWGLTATEAMACGAALCSTDNGGVDDFAVDGESALISPVKNAERLFKNLERLVIDDELRNKIAVNGQQNVLKLTFDSSAHLFEHAIDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN28</accession>
    <name>F9UN28_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1235"/>
    <dbReference type="EnsemblBacteria" id="CCC78617">
        <property type="protein sequence ID" value="CCC78617"/>
        <property type="gene ID" value="lp_1235"/>
    </dbReference>
    <dbReference type="GeneID" id="57024857"/>
    <dbReference type="KEGG" id="lpl:lp_1235"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1047"/>
    <dbReference type="eggNOG" id="ENOG5033A2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181401_0_0_9"/>
    <dbReference type="OMA" id="NEMCEAN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1058-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8197" checksum="3F8E2BB15B084A00" modified="2011-10-19" version="1">MKTLDLSFKTSTNKVHHLKLHYANDNLSKDVVSKAMADLAATKLFVKDGENLVAEPLAAKYVETIETPIVTAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN62</accession>
    <name>F9UN62_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosyl-diacylglycerol 6-beta-glucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643293.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1276"/>
    <dbReference type="EnsemblBacteria" id="CCC78651">
        <property type="protein sequence ID" value="CCC78651"/>
        <property type="gene ID" value="lp_1276"/>
    </dbReference>
    <dbReference type="GeneID" id="57024892"/>
    <dbReference type="GeneID" id="66449149"/>
    <dbReference type="KEGG" id="lpl:lp_1276"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1083"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UN62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1093-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="154"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="39593" checksum="7C0464B3E3E02177" modified="2011-10-19" version="1">MLDITMFSKADSVKGQGVGSAYLELMRLLRTHWQDEFNIKVNRYGRSAVSHYHTVNPMFYLSTFMPNRGRKIGYVHFLPETLEGSLKLPRPFQMIFNRYLISFYKRMDHIVVVNPTFIPKLEAYHIKRADVTYIPNFVSKREFYEMTKAKQLRLRQQYGYDQNKFMIIGTGQIQDRKGVPDFITLAKQNPDIQFVWAGGFSFGRITDGYQELKQVVDNPPANLSFPGIVPREKLVDYYNMADLFLLPSYNELFPMSVLEAFSCGTPVLLRDLDLYRAIIDGYYQAASDVDDMQRQIDQLRHNPAGLQFLHDKAVLAAQDYSEERLAKVWHDFYLQQAKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN95</accession>
    <name>F9UN95_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate ABC transporter,ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC</name>
        <name evidence="6" type="ordered locus">lp_1324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889198.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1324"/>
    <dbReference type="EnsemblBacteria" id="CCC78684">
        <property type="protein sequence ID" value="CCC78684"/>
        <property type="gene ID" value="lp_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1324"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1116"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UN95"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1142-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="40380" checksum="44211F2DBC329238" modified="2011-10-19" version="1">MGITLQNITKTYDKAKQPVLNDVNAEIQDGELFVIVGPSGCGKSTLLRMIAGIIPITSGKLAINGQIMNAVPPKDRKLSMVFQSYALYPFLDVAANVAFGLQARKMPAAEVERRVNAALKMVNLTAYRDRKPRELSGGQRQRVALARAIASDAKVCLMDEPLSNLDAQLRVRMRTEIRELQRKLGLTLIYVTHDQTEAMTMADHVMVLNERHVQQIDTPLDIYNHPANHFVAEFFGTPQINLLPVVTKTARNLHVAEGFQIALNQPLNAGSYTIGIRPNQLNVVPVTDERGNGKVTNVETLGEMTIIEVQADNGTALRVAQSGQVQLPLEQRVNVTVNGKIFIFDEHEQLIAEEEGVTSDQLVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE2</accession>
    <name>F9UNE2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+ driven multidrug efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643131.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889245.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1386"/>
    <dbReference type="DNASU" id="1062548"/>
    <dbReference type="EnsemblBacteria" id="CCC78731">
        <property type="protein sequence ID" value="CCC78731"/>
        <property type="gene ID" value="lp_1386"/>
    </dbReference>
    <dbReference type="GeneID" id="57025028"/>
    <dbReference type="KEGG" id="lpl:lp_1386"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1162"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="OMA" id="VGNWIGS"/>
    <dbReference type="PhylomeDB" id="F9UNE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1191-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="463" mass="50175" checksum="82FB674E9525A165" modified="2011-10-19" version="1">MNDLTKGKPLKLIFWFTIPLLIGNIFQQFYSLSDTLIVGQTLGVKALAAVGSTGSVQFLIIGFAQGLTAGLSILTAQHFGARDFKAVRRSFAISIVVSLIVGIILTILSLIFVDHILLLMQTPTDIIADARTFLQIMLGGMLAPIAFNLLSNIIRALGDSRTPLWFLIISALINIGLELLFILVFKWGIAGASWATILAQTIATLMCVVYIIVKVPILHIGRRHFKLVWSEVKAHLNVGLPMAFQMSIIAIGTIVLQAALNSLGTNSVAATTAAQKIDQVATQPLMSFGVTMATFAAQNYGAHQYERIITGVKQTMWLSGSFSVAAGLIEIIWGKQLVGFFVGHQDMAVLNLSQTYFNVIGSTYILLSMLFIMRNTLQGLGRSAIPTLAGAAELFMRVFAALILVRIFDYAGACSSEPLAWLGSCAVLLPAYIKSVHDLRQQARMTNTVAEGAEPILNDSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE8</accession>
    <name>F9UNE8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1394"/>
    <dbReference type="EnsemblBacteria" id="CCC78737">
        <property type="protein sequence ID" value="CCC78737"/>
        <property type="gene ID" value="lp_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1394"/>
    <dbReference type="eggNOG" id="ENOG5030A14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2302329_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="11386" checksum="E8CD285316828147" modified="2011-10-19" version="1">MRKQPQTLVIGGTQVASGKSLLTLALANVLTNWKMTVTIVSCNYQTVTWRTIQKHHCHEWQSDIRTANELNNFWIALQGVQTDYLLIDLDSTGPKHDNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF5</accession>
    <name>F9UNF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbg3</name>
        <name evidence="3" type="ordered locus">lp_1401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101391.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1401"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78744">
        <property type="protein sequence ID" value="CCC78744"/>
        <property type="gene ID" value="lp_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1401"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1175"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="YQFVASA"/>
    <dbReference type="PhylomeDB" id="F9UNF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1205-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="490" mass="55837" checksum="BEFC69CA2173BD95" modified="2011-10-19" version="1">MQFPADFYWGGATAANQCEGAYDVDGRGLTMKDITTMGGLNQRRQVTYLQADGTPGKGDSIPAGAHGAVLPDDYYPNQTSIDFYHRYQEDIALFAEMGFKMYRMSISWSRIFPRGDENEPNQAGLDFYRRVFETLKKYEIEPLVTISHFDMPLYLEETYGGWNDRRMIGFYQHYAETLFTAYRGLVKHWITFNEINNTIMFLALRAKAGDADYQRAYQQLHYQFVASALAVQQAHAIDGENKVGCMICGITSYPLTCDPADVLQNRYVWEQNIYYCGDVQCQGQYPTYARRLWNEHQVDLDITDSDLEALKAGTVDWYTFSYYMSTAVTTHEVSATVGGNFSMGARNPYLQYSEWEWADDPAGLQYYLELMNDRYHLPLMVVENGLGAKDYLTVDGQIHDVYRISYLRKHIQAMATAIHHGVKLIGYTSWGCIDLVSAGTGQMSKRYGLIYVDRQDDGSGTLARIPKDSFYWYQRVIASNGQDLGPSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNJ4</accession>
    <name>F9UNJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1453"/>
    <dbReference type="EnsemblBacteria" id="CCC78783">
        <property type="protein sequence ID" value="CCC78783"/>
        <property type="gene ID" value="lp_1453"/>
    </dbReference>
    <dbReference type="GeneID" id="66449286"/>
    <dbReference type="KEGG" id="lpl:lp_1453"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1216"/>
    <dbReference type="eggNOG" id="ENOG5030A4P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2142675_0_0_9"/>
    <dbReference type="OMA" id="EPHVTIM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1244-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="113" mass="12771" checksum="EAF667D6C6782D08" modified="2011-10-19" version="1">MAKFIRNSLIGLGLSAATYMLINQKTPKALYTDIKSYVQDVLDAADNLQDAREEFSDAQSNLSVQMAHAAEVFDDIQTELDKFQFKIEPHVAIMKKRADHLQDTLDHLTKTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL1</accession>
    <name>F9UNL1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein, NifU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufU</name>
        <name evidence="2" type="ordered locus">lp_1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889314.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1471"/>
    <dbReference type="EnsemblBacteria" id="CCC78800">
        <property type="protein sequence ID" value="CCC78800"/>
        <property type="gene ID" value="lp_1471"/>
    </dbReference>
    <dbReference type="GeneID" id="57025100"/>
    <dbReference type="KEGG" id="lpl:lp_1471"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1233"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_9"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="PhylomeDB" id="F9UNL1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1261-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="16740" checksum="C28CC7AC0CEE7B53" modified="2011-10-19" version="1">MGLSKLSGLYREVILDHGDHPHHKNALPNATHAITLKNPTCGDVINLAIQLDAHDQIEDIGFTGEGCTISQASASMMTDAVMGKSKEQALAMAKTFSDMAIGKQHPQADMDALEDAAILSNIMQFPARIKCATLAWWALQRALLAENGNEEESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL4</accession>
    <name>F9UNL4_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Iron chelatin ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fecE</name>
        <name evidence="5" type="ordered locus">lp_1475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101421.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1475"/>
    <dbReference type="EnsemblBacteria" id="CCC78803">
        <property type="protein sequence ID" value="CCC78803"/>
        <property type="gene ID" value="lp_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1475"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1237"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_9"/>
    <dbReference type="OMA" id="VHHQFQL"/>
    <dbReference type="PhylomeDB" id="F9UNL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1264-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="27964" checksum="A569068DCAF9E06B" modified="2011-10-19" version="1">MTALLSAEHLAFHYPKQTDLFTDLQLQLHHGEILTLLGPNGIGKSTLLKCLLGLLTPTAGTLTLNGQPLATLTPKQRARIIAYVPQTIPTTTSLSVRDYLLTGRTPYLNFAQSPGATDVALADRILKTLQLSELTARTINTLSGGQAQLVTIARALMQEPELIILDEPTAALDFGRQQQLLSLVQQLAGQNIAVILTTHNPNHALILKQRVGLFGASGHFDYGGIELLTEPRLRATYQTKLRLLYVPELGRTICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM1</accession>
    <name>F9UNM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS assembly SUF system protein, DUF59 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101428.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889324.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1482"/>
    <dbReference type="EnsemblBacteria" id="CCC78810">
        <property type="protein sequence ID" value="CCC78810"/>
        <property type="gene ID" value="lp_1482"/>
    </dbReference>
    <dbReference type="GeneID" id="49284202"/>
    <dbReference type="KEGG" id="lpl:lp_1482"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1244"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_0_9"/>
    <dbReference type="OMA" id="LRMIIDP"/>
    <dbReference type="PhylomeDB" id="F9UNM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1271-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="11956" checksum="94516E8E23ED63D5" modified="2011-10-19" version="1">MADGIGEGAEFSPIEDAVMKSLEDVIDPELGIDMVNLGLIYDIHVDDDGNCVVTMTLTTMGCPLGNLLADQINRAVTSVDGVTGCEIDLVWEPAWDMSKMSRFAKVALGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ2</accession>
    <name>F9UNZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine specific protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pppL</name>
        <name evidence="2" type="ordered locus">lp_1618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889445.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1618"/>
    <dbReference type="EnsemblBacteria" id="CCC78931">
        <property type="protein sequence ID" value="CCC78931"/>
        <property type="gene ID" value="lp_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1618"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1366"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_9"/>
    <dbReference type="OMA" id="EDHTWVA"/>
    <dbReference type="PhylomeDB" id="F9UNZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1393-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="27258" checksum="C5CC4769FA0466D8" modified="2011-10-19" version="1">MDFAYRSDIGQQREENEDYVGFFQNKAGINFAIVADGIGGHQGGDVASEMVVSHMGFRFENTTFKEPNDAVKWLASEVQDENQHIIEKAREFSDLNGMGTTMVAALLFDQKFLMANIGDSRGYLFRDGQLHQLTEDHSLVNELVKRGEISAEQARQHPQKNIITRTLGISPDADIDTNLYQIQPGDQLLLCSDGLTNMVTDQQLASVLATTQTSTQKCETLIKLANAAGGKDNITALLMALDGEVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ9</accession>
    <name>F9UNZ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase, dihydroxyacetone kinase family</fullName>
            <ecNumber evidence="3">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.29" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101481.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889452.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1626"/>
    <dbReference type="EnsemblBacteria" id="CCC78938">
        <property type="protein sequence ID" value="CCC78938"/>
        <property type="gene ID" value="lp_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1626"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1374"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_9"/>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="PhylomeDB" id="F9UNZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1401-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="568" mass="60785" checksum="6DBA6944349B0BB9" modified="2011-10-19" version="1">MKITTITNLEFGKMVQAASQKLNQRAEFINSLNVFPVPDGDTGTNMSLSMASGAKYEREETSTKVGDLASALAKGLLMGARGNSGVILSQIFRGFSKAVADKEILTANDLAAALAAGAQTAYKAVMKPTEGTILTVIRKAAGAGKEAVKTTDDICEVMDAVVTAAEAALKSTPDLLPVLKQVGVVDSGGQGLTFVLEAFSDSLSGKVDESQDYVPDDAEMDSMIDAAHHQSVQGQLDPNDIKYGYCTEIMVRIGDGKLVDHKFDYDTFYEYLAKLGDSLLVINDDEIVKVHVHTEHPGDVMTWGQRFGALIKVKVDNMRLQQETIMEHDKEDEAQAAAEPALPSQPQVDMHGYAIISVSSGDGIGKLFKGLGVTDIIAGGQTMNPSTADIVKAVNDSGAQQALVLPNNKNIFLAAEQAAEVADVPVKIIHSQTISQGMTAMLAFNAEADLDDNQAAMEETLSTVVSGQVTHAVRDTTIDGLEIKKDDYMGLVDGKIVITNPDRDTAALDMVKAMLDEDSELVTIIYGKDATKTDADHLAAKVQELDDELEIEIHEGDQPVYPFLVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP48</accession>
    <name>F9UP48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1685"/>
    <dbReference type="EnsemblBacteria" id="CCC78987">
        <property type="protein sequence ID" value="CCC78987"/>
        <property type="gene ID" value="lp_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1685"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1423"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="KYIMALE"/>
    <dbReference type="PhylomeDB" id="F9UP48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1450-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="33500" checksum="8D70261AFAD4A7DE" modified="2011-10-19" version="1">METRKLAVFVDLATTQNYSRSAERMFLSQSTISKYIMALERDWQVQLFERAHRQVTLTRIGQQLLPRAQAILREERQLQQVLAANTAHNAQSLVVQGLPSLAQYQAFHIITAFTKRYPEVKLQFSEASVDRLAHALDHTNVDIVFTRIFGDQPNNYDVLLNETDQFVVLVPKDDPLAQQAEISLSMLAHESILLLKDTIGEDNPLFSAFQKMHTPQMVYDGQRIDLILEMLNQGDGVSVVMARSFDLTGFDNIKAIPLTPTIRSQMAFMKRPDNHAAVVAKFWAFATKYSQSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP55</accession>
    <name>F9UP55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1693"/>
    <dbReference type="EnsemblBacteria" id="CCC78994">
        <property type="protein sequence ID" value="CCC78994"/>
        <property type="gene ID" value="lp_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1693"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1429"/>
    <dbReference type="HOGENOM" id="CLU_2633665_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1457-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="77" mass="9160" checksum="C71577BF85F63606" modified="2011-10-19" version="1">MNIMKPCAIERGFCAMSRTMIIEESKDAFIEALFQLLANESFEHITVKQLTLESGYSKRTYYRYFKTKNKNFRYSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD7</accession>
    <name>F9UPD7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2087 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644395.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1789"/>
    <dbReference type="EnsemblBacteria" id="CCC79076">
        <property type="protein sequence ID" value="CCC79076"/>
        <property type="gene ID" value="lp_1789"/>
    </dbReference>
    <dbReference type="GeneID" id="57025403"/>
    <dbReference type="KEGG" id="lpl:lp_1789"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1510"/>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096125_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1539-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="28050" checksum="757C06EDC4CA4BCF" modified="2011-10-19" version="1">MDLTSLTIDDLKRGWHQTATARYCNYCDASWETTTAAATIEQHLTIVHGGIQSPLIHLASRYNTLTTKQQNLLTAFATGIKDADLAKQFQLAAATIRHQKFTFREKAKQAKLYLAIYQSVFESGQTPNDLIVLPEQPGIIDDRFAITEDEAVQTLKQYFNFDHDPLQLKRWPKKQKTIVTILTRIIDEIPMNRPINEDELNHYLQPIYFDYTTLRRYLIDYGFLKRTVDGRQYWRTTTKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE8</accession>
    <name>F9UPE8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose-1-phosphate uridylyltransferase, HIT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.1522"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="262" mass="29153" checksum="6FDC9E2F7F17817C" modified="2011-10-19" version="1">MPNQPLIFDTAIAKDKPENIRHPHNACPFCDPGQLTDIIAQDADRIWLLNKFPTLQATWQTIVIEAARHDGDIATYSSAQNRAVFTFALKHWQATIASGRFKSVLCYKNFGPHSGGSLRHPHMQIVGLMAADGYANVTAANLTGYSVLAVDQVQVTVSDRPIMGFVEINVAAPATAIAPLADAVQQVVQYTLNTYFHGQCDSYNLFFYPRDDQIVAKVVPLFNVSPYYIGYRLAQADTPKRMRAIAEEIRQQFERSNLAHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ8</accession>
    <name>F9UPQ8_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">lp_1937</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889711.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1937"/>
    <dbReference type="EnsemblBacteria" id="CCC79197">
        <property type="protein sequence ID" value="CCC79197"/>
        <property type="gene ID" value="lp_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1937"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1634"/>
    <dbReference type="eggNOG" id="COG4334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133265_0_0_9"/>
    <dbReference type="OMA" id="RPVTIWI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1659-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028498">
        <property type="entry name" value="UCP028498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="144" mass="16314" checksum="7B2B1E2CF3CA4280" modified="2011-10-19" version="1">MNKSNQPVVSTTVTTMQWSRAQLAAFSTADDFQVSPFYSDGQTYGTPTWIWSVVVGQQLFIRAWNGPRSRWYRSAVTQRAGRIHLAESNHLVNFVPICDEQLNNQIDQAYRQKYAGSPYLMPMLASGPRQATVQVMPRISKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ42</accession>
    <name>F9UQ42_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, DeoR family, fructose operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fruR</name>
        <name evidence="5" type="ordered locus">lp_2095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889845.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2095"/>
    <dbReference type="EnsemblBacteria" id="CCC79331">
        <property type="protein sequence ID" value="CCC79331"/>
        <property type="gene ID" value="lp_2095"/>
    </dbReference>
    <dbReference type="GeneID" id="57025638"/>
    <dbReference type="GeneID" id="66449866"/>
    <dbReference type="KEGG" id="lpl:lp_2095"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1772"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_3_9"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="PhylomeDB" id="F9UQ42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1792-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="251" mass="27699" checksum="19A5EE5D638EFA2A" modified="2011-10-19" version="1">MLTEERQQYILNTIRFKGIIKIKDICSETRCSESTARRDLQQLEEQGELLRVHGGAKYMNSLQEEPAMNDKVSRNVNAKDHIAQQAVANIQVDDVIYLDAGTSTLAMIHHLNPSYNLRVVTNGVVHASALADMGIQTYLLGGNLKGTTKAVIGPEAVKSLEEYRFNKVFLGINGVHPKFGLTTPDPDEAVVKKTAILQSEESFILADNTKFDHVSFARVGDLSSATIITDQLTPSVAEQYQPLTTIQEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA4</accession>
    <name>F9UQA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889907.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2169"/>
    <dbReference type="EnsemblBacteria" id="CCC79393">
        <property type="protein sequence ID" value="CCC79393"/>
        <property type="gene ID" value="lp_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2169"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1834"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106613_0_0_9"/>
    <dbReference type="OMA" id="AVCYYMQ"/>
    <dbReference type="PhylomeDB" id="F9UQA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1854-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="224" mass="25414" checksum="99DC2A485C574B60" modified="2011-10-19" version="1">MAKTSRPSKAKQQALVHQLIGKIDAQPEDYHAYYELVVLLTAGQDFEQAEALAMKALGKFDHQQPAADYLRYALGNVYYQAQTYDKALPYYQQITDDQLKQDAYLMSAQALMAQHDYQHALVWAITAQEARPQQLDANLLVADILLALGNNQQASDYYQRAYKIDSQSGRAAFNLGLTAMVLGKPYATWFERAQKLDSQYFKSHQQQLTDIEKMLAAQADNQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB4</accession>
    <name>F9UQB4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mtn</name>
        <name evidence="7" type="ordered locus">lp_2181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644605.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889917.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2181"/>
    <dbReference type="EnsemblBacteria" id="CCC79403">
        <property type="protein sequence ID" value="CCC79403"/>
        <property type="gene ID" value="lp_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2181"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1844"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_2_2_9"/>
    <dbReference type="OMA" id="DQFVHSK"/>
    <dbReference type="PhylomeDB" id="F9UQB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1864-MON"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="230" mass="24505" checksum="2034D56FCB1E4B3B" modified="2011-10-19" version="1">MKFGIICAMEEELKTLRDALQDEKIVNIKDITFYDGTIDQQEVVLVQSGIGKVQAGMTTALMITNFDVDVVINSGSAGGIGAGLHVGDVVVAKATAYHDVDATAFDYEYGQLPQQPLYYETDANWVKQIMAAAKATGLNAKTGLIVSGDQFIAGKVATDKILAHFPEALSSEMEGAAIGQACHQFQTPYVVIRAMSDVGDENAGVSFDEFILEAGKQSAAMLLALFAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP4</accession>
    <name>F9UQP4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2340"/>
    <dbReference type="EnsemblBacteria" id="CCC79533">
        <property type="protein sequence ID" value="CCC79533"/>
        <property type="gene ID" value="lp_2340"/>
    </dbReference>
    <dbReference type="GeneID" id="57025877"/>
    <dbReference type="GeneID" id="66450090"/>
    <dbReference type="KEGG" id="lpl:lp_2340"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1978"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="VHYSIEF"/>
    <dbReference type="PhylomeDB" id="F9UQP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2017-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="160" mass="17551" checksum="70141491D1B5BACF" modified="2011-10-19" version="1">MLQQYQHILVPVDGSYEAELAFKKAVAVAKRNGPNASVHMVHVVDTRAFQNISSFDTTMVEQVTDTAQKTLDKYVAEAKADGLDNVDYSIEYGAPKTIIARDVPKDMGIDLIMIGATGLNAVERLLIGSVTEYVTRMAVCDVLVVRTDLENKPAPKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ9</accession>
    <name>F9UQQ9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB2</name>
        <name evidence="2" type="synonym">mreB</name>
        <name evidence="3" type="ordered locus">lp_2359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2359"/>
    <dbReference type="EnsemblBacteria" id="CCC79548">
        <property type="protein sequence ID" value="CCC79548"/>
        <property type="gene ID" value="lp_2359"/>
    </dbReference>
    <dbReference type="GeneID" id="57025892"/>
    <dbReference type="GeneID" id="66450105"/>
    <dbReference type="KEGG" id="lpl:lp_2359"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1993"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_9"/>
    <dbReference type="OMA" id="MDIFQPS"/>
    <dbReference type="PhylomeDB" id="F9UQQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2032-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="35829" checksum="60F699ACA36B8F01" modified="2011-10-19" version="1">MALDIGIDLGTANVLIYVSGKGIVLNEPSVVAIDTNTNQVLAVGSEAYQMVGKTPSNIRAIRPLKDGVISDFDVTEEMLSYFIKKLNVRGIMSRPSIMICTPTNTTEIERKAILQAAEKSGGNKVYLEVEPKVAAIGAGMDIFQPRGNMVIDIGGGTSDIAVLSLGDIVASSSLRMAGDRMNQDIVNYVKDQHHLLIGERSAEQVKIQIAQVFKQDGDDDKVTQVRGRDTVTGMPRSIDIDSNQVEEAIHETLMQIVSTAHHVMETLPPEIAADIIDRGITLTGGGALLSGLDQLISENLKVPVMVAEHPLNNVAQGAGILLEHMQKTAKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS3</accession>
    <name>F9UQS3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641435.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890076.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2376"/>
    <dbReference type="EnsemblBacteria" id="CCC79562">
        <property type="protein sequence ID" value="CCC79562"/>
        <property type="gene ID" value="lp_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2376"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2008"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_1_9"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="PhylomeDB" id="F9UQS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2047-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
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        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="36275" checksum="55859297C2F033CD" modified="2011-10-19" version="1">METKVYTPAEIPAAAALLTAGQLVAFPTETVYGLGADATNVDAVKQVYLAKGRPSDNPLIVHVADVETVERFAQPLSEAAKKLIKAFWPGPLTMIFKLKPDALAPEVTGGLQTAAFRNPDNEATLALIRAAGTPIVGPSANTSGKPSPTTAQHVLHDLRGKIAGILDDGPTKVGVESTVLDLSTDKPAILRPGAVTPEAIERVIGMPVQTELHHVGAKEVPKAPGMKYKHYAPNAQVYIVDRSEDWPEALAWAAQQDVPMGVMATDDILTNNQIPANCEQFSLGEDIQSASRELFAGLRHFDTETEIKDILCQAFENKGLGLAYMNRLNKSAGQTHFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT4</accession>
    <name>F9UQT4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890087.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2393"/>
    <dbReference type="EnsemblBacteria" id="CCC79573">
        <property type="protein sequence ID" value="CCC79573"/>
        <property type="gene ID" value="lp_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2393"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2018"/>
    <dbReference type="eggNOG" id="ENOG5033VWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078761_0_0_9"/>
    <dbReference type="OMA" id="NHTFVIQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2058-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394402" evidence="2">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="34377" checksum="9F4941181D426535" modified="2011-10-19" version="1">MFRKTAMVAVTAGALTLLLAGCGKTTLSTTKTTYKPNGLVAAVKGKSNVKKVHYQLDGGQTKTATVRNHTFVIQVPTKTTRQTVKIKAGSDTTTVHVKGAKKLVGYQKMATTYNQALIASKLSKSDQQAAKKLQTEGAALKKQQATIQAKVKQAQAQIKAGGTAAATGAKTLQAQQTAAAQLKTKAASLQTTQKQVEAAMATAKKQVKSQLLPTKTPSDGIKNVLTTKDYKIRLNVQKGDVLGAAMIVPTKAFKNKTRQKNFGTAFALMTTTTGANAKKVMKQFQKETKDNSGSTTTIDPITSKGVRFTIGVSTSDLYIFMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT9</accession>
    <name>F9UQT9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P2a protein 58, holin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101731.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2399"/>
    <dbReference type="EnsemblBacteria" id="CCC79578">
        <property type="protein sequence ID" value="CCC79578"/>
        <property type="gene ID" value="lp_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2399"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2025"/>
    <dbReference type="eggNOG" id="COG5546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1990525_0_0_9"/>
    <dbReference type="OMA" id="IQQVFAM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2063-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006485">
        <property type="entry name" value="Phage_holin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04531">
        <property type="entry name" value="Phage_holin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="125" mass="12960" checksum="BE717CF8C34F334D" modified="2011-10-19" version="1">MKKISFKNADGSLNGKLIAGIISLLIVLIQQVFAMFGIKFTGDWSAIVAVINTVLTILGMLGVVTDVQTVTAPTVKNDEESQVEAAANEVADETPTPTSTVAVVNSSAASDTEMASESASQASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU9</accession>
    <name>F9UQU9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P2a protein 48 tape measure protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2409"/>
    <dbReference type="EnsemblBacteria" id="CCC79588">
        <property type="protein sequence ID" value="CCC79588"/>
        <property type="gene ID" value="lp_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2409"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2035"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003937_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQU9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2073-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013491">
        <property type="entry name" value="Tape_meas_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20155">
        <property type="entry name" value="TMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02675">
        <property type="entry name" value="tape_meas_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="TMP_3" evidence="3">
        <location>
            <begin position="223"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1357" mass="149103" checksum="8CE6BEDAE7E6C929" modified="2011-10-19" version="1">MSAVVEKTFVWKFMDQISQGVANARQAMDEAVHAAADMGSKVSESGEKWHNYASKQKEAMDEAKANFNEYKDQVTNSSNSIREKISGLIDRLKEIPHDVVTTLKSKINDENIGIFSRKVRDVPKERSVLLRVKDHFTDIFKHFRERIKQTPKKHSLLLKIKDGFSNGFKKFNENAKKTRENGHRLRDIIEGTFVGNALYSAYDKVKDGIVEATKAGYDFDKEQQVMLQTWTTLTGSASQAKGMVSTINDLSKKTGQASDLVNELEQGFYHLHSSKPEADELSKAMLNMGDAVGLTGDQMKSVTQDMVHGLATGKVSAGELNQIGAYFPMIDEALAKHEHTTVAGMRNMARQGKITGKDMESVFTELGNHKYGKAADNMLKTMTGMQRTVKAQMPKLLGDIEQPLLKAQNPIFGTISKWVSETHTENLFKDLGNKVSKGFATVTKAFTGGNFTGKGFTNTLNKMVENAGKSVDKFSAWLAKNAGNIKAFGSIVKSSLTIAFKVVGAVISDVVSVLGFLANPLGKVSNNSKTASRSVGSLASGLKTLANNKGAIKAIAAALTTFFIAKKILTTVMALKNMNDVLHLTTIAGRMVSAAFTPWLLIPAIIIAIGVGLYELYKHNKKFRDFVNGIWKAVTSTFGKIGKFISNTFKGAGKWFSGLIKGAQKALNTVKKFFTGKLGWEKAIGKEIGNIIKTVSKGFRQVLKTIGNILKGFGKVLMYAFLFPVGLAALILKPFIKPFTNLIKATIKTVKNLWSKLVDFLRTVFTPVINVWKVVWKAISTFFHIVWEGIYSIVKVIFKAISNFIHLELKGISIIWHIVWHAISSFFGTIWRGMKAFLLPIVEAIWNAIKDALDLIKRIWHSIWNSISSFFSNIWDRISQIAKTATHWLSSHISDVLDSISNVWHSMWQGLSDFFGDVWKGIKKAAQDGINGVLSVINAGVDAIDSVWKFFTGHKTSIHHLEPVKFAQGGVVHTRLSMVNDGAGQNWKELLQLPSGELKMTHQRNAVLPLPAGTRVYNGDETAAIMASAGVDHYAHGGIVGNAINWTKGKLSDIGSWIGDKAKAVDKFLKDPLGNISNLLHKATDGLFKGAASFGELASGAIGKLSSIAVNKFKEMLNSTKKKLEVTDGKAGHYNPGLIDKAARMMGIDSLPAGFSELLQATIMSESGGKSVIQTVHDVNSGGNEAGGILQYTPGTFAAFAMPGHTNRMNPLDELLAFFNNSDWRNSIGHTSIWGVPKVDWLHSGPQGSRRFAHGGEVFDEQTTIIGDNSQHHEFVINPYDVTAYPLLAKAMDTTMRAQPVSTQTNNNHENDNETNSLLRQANALLQIIADKKPELLDDLAAKLRQKDAQTFRMQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR48</accession>
    <name>F9UR48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890201.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2523"/>
    <dbReference type="EnsemblBacteria" id="CCC79687">
        <property type="protein sequence ID" value="CCC79687"/>
        <property type="gene ID" value="lp_2523"/>
    </dbReference>
    <dbReference type="GeneID" id="57025951"/>
    <dbReference type="GeneID" id="66450239"/>
    <dbReference type="KEGG" id="lpl:lp_2523"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2123"/>
    <dbReference type="eggNOG" id="ENOG5030AE7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198968_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2180-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="8824" checksum="2833397BDF8D9213" modified="2011-10-19" version="1">MLHGTFYGVILISFLIGIGVQWYFREYFQLLVFGHSVEILFMMVLGWYQFGMLVLLPLLVLWGIGLGAIYVMNRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR87</accession>
    <name>F9UR87_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642701.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2573"/>
    <dbReference type="EnsemblBacteria" id="CCC79726">
        <property type="protein sequence ID" value="CCC79726"/>
        <property type="gene ID" value="lp_2573"/>
    </dbReference>
    <dbReference type="GeneID" id="57025988"/>
    <dbReference type="GeneID" id="66450277"/>
    <dbReference type="KEGG" id="lpl:lp_2573"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2162"/>
    <dbReference type="eggNOG" id="ENOG5030RAC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2717348_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2218-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="72" mass="8110" checksum="5767B86822613A2A" modified="2011-10-19" version="1">MDYSSLLGPDRYDLAVTLAKQYHLDPSQVLFGYLQVVSQVTGGPNAAQADLHEPQVRAAINQEFDHFLKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR90</accession>
    <name>F9UR90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell surface adherence protein,collagen-binding domain, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_2578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101833.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890243.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UR90"/>
    <dbReference type="EnsemblBacteria" id="CCC79729">
        <property type="protein sequence ID" value="CCC79729"/>
        <property type="gene ID" value="lp_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2578"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2166"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026776_0_0_9"/>
    <dbReference type="OMA" id="YVENHAN"/>
    <dbReference type="PhylomeDB" id="F9UR90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2221-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041171">
        <property type="entry name" value="SDR_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17961">
        <property type="entry name" value="Big_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388962" evidence="8">
        <location>
            <begin position="29"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Big_8" evidence="10">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="9">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="9">
        <location>
            <begin position="403"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="705" mass="72184" checksum="D28AE1939BFA2D52" modified="2011-10-19" version="1">MRRKLVGYMLSMLTVILALFMLGSTAHAKEISVTGLTAGNAIVLDANGKPVTDTSTLNDKAGYQLTYHWSIPDSEVIKAGDTATVEIPTYVSIDHDVVMPLTDSAGQTLGTFTYTKGASTGTITFTDALGTLNSRAGTLSMNAKGNATATEGSAEIAKSGLVVSSESDGAPTVLGWHITVTPGNNSTVVVTDTLGPNQTFIPDSVAAQAVQIINGIQVPQQPLTPTVATNGNVITFTFNNIHSPFVITYNTKVENFNPADTAKWHNTAALDGLGVDATADITYGGNGTAGMTYTIELTKHDAATKAVLAGAVYELQDSTGKVIQTGLTTDSQGQLIVKNLRAGDYQFVETKAPLGYELNTTPVKFTLGGIKPEVAFQVSQDDVKQPVVPTTGDVTLTKTDATTKAALAGAVYELQDATGKVLKMGLTTDTTGQLTVSGLTAGNYQFVETKAPSGYQLNAAPLSFTIKPNQTAVVTVAATDEPVTEPGTTEPSKPGEPGTTEPSKPGEPGTTEPSKPGEPGTTEPSKPGEPGTTEPSKPGEPGTTEPSQPGEPGTTEPSKPDEPGTTEPSQPGKPGKPGEPGTTEPGNPGTTGPTAPQPERPAVPGPSQPAAPKPGQSGLGQPALPGLIKQPSTGVNGAGGTVGNGVTTGMNGFGTPTGSDQSTSAGYNHGTLPQTSEKQSPIWVIFAGLLGLLIAAVGIGYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD3</accession>
    <name>F9URD3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79772">
        <property type="protein sequence ID" value="CCC79772"/>
        <property type="gene ID" value="lp_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2635"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2210"/>
    <dbReference type="eggNOG" id="ENOG5030A23">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2260201_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2263-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11101" checksum="65CC9814A49247F2" modified="2011-10-19" version="1">MVAGLMAKEKHEIYDEQDKRLGRLILKILGIVAIVSGLVGPFIYLLNANWGRELGTLAVICGGVAICLGPKGRTAGGQWLALLKTLGLSILILGYFVIVLKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG1</accession>
    <name>F9URG1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleotide reductase protein NrdI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdI</name>
        <name evidence="1" type="ordered locus">lp_2673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642628.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890314.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2673"/>
    <dbReference type="EnsemblBacteria" id="CCC79800">
        <property type="protein sequence ID" value="CCC79800"/>
        <property type="gene ID" value="lp_2673"/>
    </dbReference>
    <dbReference type="GeneID" id="57026061"/>
    <dbReference type="KEGG" id="lpl:lp_2673"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2239"/>
    <dbReference type="eggNOG" id="COG1780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114845_1_0_9"/>
    <dbReference type="OMA" id="DFMMDSV"/>
    <dbReference type="PhylomeDB" id="F9URG1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2291-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18211" checksum="5A6DED7492F05211" modified="2011-10-19" version="1">MSESTINIIYISIEGNTRSFVTGMQDYAKTQHAADDSNPLITLKEITEQSDFAIETEPYFAFVPTYLDGGNGIDNGVKELMTNVLGEYLNYDQNSRFCLGVVGSGNRNFNDQYCLTARRYAEQLDTDMIADYELRGTAVDTERVYNVMKDRLAAYLDNQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG7</accession>
    <name>F9URG7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gpd</name>
        <name evidence="5" type="synonym">zwf</name>
        <name evidence="9" type="ordered locus">lp_2681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC79806">
        <property type="protein sequence ID" value="CCC79806"/>
        <property type="gene ID" value="lp_2681"/>
    </dbReference>
    <dbReference type="GeneID" id="57026067"/>
    <dbReference type="GeneID" id="66450344"/>
    <dbReference type="KEGG" id="lpl:lp_2681"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2245"/>
    <dbReference type="eggNOG" id="COG0364">
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    <dbReference type="PhylomeDB" id="F9URG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2297-MON"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G6P_DH"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
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            <end position="490"/>
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    <feature type="active site" description="Proton acceptor" evidence="5">
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            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <position position="179"/>
        </location>
        <ligand>
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        <location>
            <position position="183"/>
        </location>
        <ligand>
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        </ligand>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        </ligand>
    </feature>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="494" mass="56786" checksum="46018F265C3BFA56" modified="2011-10-19" version="1">MSNEKIALFTIFGGTGDLAQRKLYPSLFKLYQKGYLKDHFAVIGTARRPWTDDHYHEVISDSLADLNADQETVTQFASHFYYQSHDVTDAEHYRTLKKLSEKLDAQYGLQGNRIFYLAMAPNFFGTIAQHLRSENILTDNGFNRVIIEKPFGHDYESAKELNDQLTATFNENQIYRIDHYLGKEMIQNITAIRFGNNIWESLWNNRYIDNVQITLSEKLGVEERAVYYDNSGALRDMVQNHILQILSLLTMDQPVEFTENDIDVEKVKALRSLRPLKPEEVATNFVRGQYGAGDDAKAYRDEDKISSDSNTDTFVAGKVMIDNYRWSGVPFYIRTGKRLADKFTRIDVVFKRPVVNIFNHEDVRANDDAATSLDPNILTINVEPTEGFELRMNAKAIGQGFATTPVKLNYSHDAEATAGSPEAYERLLHDALNGDATNFTHWQEVADSWKFVDVIQKYWDEHQPEFPNYRPGTMGPDAADELLRQDGHRWVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URI7</accession>
    <name>F9URI7_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Purine transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ordered locus">lp_2708</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645875.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2708"/>
    <dbReference type="DNASU" id="1063005"/>
    <dbReference type="EnsemblBacteria" id="CCC79826">
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        <property type="gene ID" value="lp_2708"/>
    </dbReference>
    <dbReference type="GeneID" id="57026086"/>
    <dbReference type="KEGG" id="lpl:lp_2708"/>
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    <dbReference type="OMA" id="CQISETA"/>
    <dbReference type="PhylomeDB" id="F9URI7"/>
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    </dbReference>
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        <property type="entry name" value="PucR_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="463"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="529" mass="59874" checksum="5D0F42FC4BEF3589" modified="2011-10-19" version="1">MRLQTLLQTPSMQHMRVIAGERGLKREISNIGMIESPDIADYLANGQFLITNGYPFVNTTTDPLTLIKAMHNANCAGLGFKDHRYVDHLPKKVIELANELAFPIIITPGDELISETMRKMLSIILKSQTNELSRIVKANQTLADLLLKDPTNTTVLNKCSELIHHPLFLMDSHFRVVSASQDLPMTRNTLTDFLRNQTDIDYFNLNTRVILPYQANDLTIMPLFSAYKENKAFVGVVDLDPANSTDQMLTQVVLNTLSFVNGRVDMLNESAFRNQSGFYLNVMDGGISNDLVNKTLKARNIDPSTKFHCATILVTTNHQALLSNHLLEQVQQLTLWFIKEYQASVIVFSLKQQLVLLINDQQNAQHFLTALVQFIQPKLDRQARLIAGYSYSTLPLTELATTYNEAAEALALSKNSPHAVTIYRPKYVKELISLIPQNEARSFVERVLGGLVSGVSANEQLNLLTTLYGYFYYHQNIAEVAGHLDIHRNTVIYRLKKIEKMLTLNLDDPEQTQTLEMAVLLWHNQQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL7</accession>
    <name>F9URL7_LACPL</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">lp_2743</name>
    </gene>
    <organism evidence="5 6">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890370.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2743"/>
    <dbReference type="EnsemblBacteria" id="CCC79856">
        <property type="protein sequence ID" value="CCC79856"/>
        <property type="gene ID" value="lp_2743"/>
    </dbReference>
    <dbReference type="GeneID" id="57026116"/>
    <dbReference type="KEGG" id="lpl:lp_2743"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2296"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="YAEHPRT"/>
    <dbReference type="PhylomeDB" id="F9URL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2347-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="32653" checksum="DA36EE627EDA3F87" modified="2011-10-19" version="1">MSIQVQAVQQAFRGQTVLDNLNLTIKPNTIYGLLGRNGAGKSTLLNIISNRIFADSGTVTMDNESMCDNDRTLGKVYLMSEVNLYSERSRVKQLFKTTALLYGDFNDTYAKKLAQTFGLDLNARFGKLSTGYRTIFKLIIALCVPAEYIFLDEPVLGLDANHREIFYQELIETYSDHPRTFVISTHLIEEITNLIEHVFVLDHHHIIVDGDVTDILGQSYAVTGPQTDVSTYTDGLNIIGKDHLGGITAHYVYGPLDNDRPIPDTVTVEHLDLQKLFVNLTNTKEEAAAHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM9</accession>
    <name>F9URM9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thrC</name>
        <name evidence="7" type="ordered locus">lp_2758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2758"/>
    <dbReference type="EnsemblBacteria" id="CCC79868">
        <property type="protein sequence ID" value="CCC79868"/>
        <property type="gene ID" value="lp_2758"/>
    </dbReference>
    <dbReference type="GeneID" id="57026129"/>
    <dbReference type="KEGG" id="lpl:lp_2758"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2308"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_3_1_9"/>
    <dbReference type="OMA" id="FGRIAFQ"/>
    <dbReference type="PhylomeDB" id="F9URM9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2359-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="103"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="497" mass="54570" checksum="DA4344785D0275CC" modified="2011-10-19" version="1">MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEVLKLFFTDYTADELHACIDAAYGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQILPHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQTRIIVFYPKDGVSAIQKQQMVTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVAYYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLTDFFNTGTYDKNREFFLTSSPSMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTITPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHTAVASAVAKQYQAATRDQRPMVVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRVADVDDMGTTIKTILNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP3</accession>
    <name>F9URP3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101912.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890396.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2773"/>
    <dbReference type="EnsemblBacteria" id="CCC79882">
        <property type="protein sequence ID" value="CCC79882"/>
        <property type="gene ID" value="lp_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2773"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2322"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_7_0_9"/>
    <dbReference type="PhylomeDB" id="F9URP3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2373-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="416" mass="45695" checksum="4523452E87359FE7" modified="2011-10-19" version="1">MRTMAIVRRVFKQMLRDKRTLALMFLAPLLIMALMYFLFQNNTTQVATLGVHNVDHQVVKAINTKHVDIHHYSSNQAKAMIKQHDLDGYLTQKDGNLTITYSNSNPTNTSLIKVSLQSGLVKLKIQTLVTATKAQKKVLQTQQVALQKLTAAQKQATVSKLKTALAQAQASGNTAAAAKIQKQLRQATASAAAPTNSQSQTTTYTTSSHYIYGSSDSTFFENFLPIFLGFFVFFFVFLISGVSLLNERTTGTLSRLLATPIRRSEIIMGYLIGYGGFAIIQTVLTVVFAITVFKIHLVGSIWLVFLTNLLLALVALTLGIFISTFANSEFQMIQFIPLIVVPQIFFAGLIPVDGMASWLQAIAHIMPLYYGANALTAVVTKGAGLGDIGVNLLILVGFMVVLTMLNIVGMKRYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ3</accession>
    <name>F9URQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890406.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79892">
        <property type="protein sequence ID" value="CCC79892"/>
        <property type="gene ID" value="lp_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2786"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2332"/>
    <dbReference type="eggNOG" id="ENOG50309UJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1650003_0_0_9"/>
    <dbReference type="OMA" id="VIHARHP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2383-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="162" mass="17462" checksum="D526C35341A4B69B" modified="2011-10-19" version="1">MKIEILPTTTTEIPLAILSMSNLDNRELNPAIEKQLAAQGLAVAQPQNALADLLQVIHARHPVQINAWDMNTLGTEQVQLHLTAQGASLSADATIPIRPNLDSKSSRILIVVGDPDASEASVHATGQELQRKIKAFFGIQARLQFPSCTTQPVSIETTRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ5</accession>
    <name>F9URQ5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">panE</name>
        <name evidence="9" type="ordered locus">lp_2788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644739.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890408.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2788"/>
    <dbReference type="EnsemblBacteria" id="CCC79894">
        <property type="protein sequence ID" value="CCC79894"/>
        <property type="gene ID" value="lp_2788"/>
    </dbReference>
    <dbReference type="GeneID" id="57026155"/>
    <dbReference type="KEGG" id="lpl:lp_2788"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2334"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_0_0_9"/>
    <dbReference type="OMA" id="WEKWVFL"/>
    <dbReference type="PhylomeDB" id="F9URQ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2385-MON"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="7">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="8">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="37952" checksum="38BF74C31D3CD896" modified="2011-10-19" version="1">MHFTVLGAGAMGLRYGVLLQEAGNQVDFVDTWQANVDQIHRQGGVYVSRDHQNRHLVPVKVSTPEDYHDDPDVWVVFTKQMQLADFLTRTAHAFNGRQYVLTCMNGMGHVEKLLHYFKPEKLLAGTALVATVLNGPGDVDFIGARGAGTMNLANYTEHPDEMTHRIVTELDKCQFHPNLTTNFRGTLLAKVVFNSVVNTLCTLFEITMGEFAAYPGADELSRQLIDEAYDVCERDGVTMLNTRAEELASVNYVSKVANPLHYPSMYQDMSHNRPTEVDYINGYLVKLGQKYHYQAKTHAFLTHLVHLAETTRQTSATTEHTTEQNAQNATEQASQQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU6</accession>
    <name>F9URU6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE5</name>
        <name evidence="2" type="ordered locus">lp_2843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890449.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2843"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79935">
        <property type="protein sequence ID" value="CCC79935"/>
        <property type="gene ID" value="lp_2843"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2843"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2377"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_21_0_9"/>
    <dbReference type="OMA" id="HEFLSAW"/>
    <dbReference type="PhylomeDB" id="F9URU6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2432-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022372">
        <property type="entry name" value="Accessory_SS_Asp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16993">
        <property type="entry name" value="Asp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="331"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="502" mass="57670" checksum="B020A5D144644B04" modified="2011-10-19" version="1">MNFFVNQYLMALNSGVEHAEFKRLQLFKDHQAPAKLVTRQFDGLLHQNMRRFNIADDQMANLFDFFRETTSFSSRVIKMADLNWPTAYDIKPDPNVSEVRAGDRLVAKVHFVPSTVGHVYFIEIFDHFNNLVQRTDYDERGFKARDEFFSSAGEPITDIFYRPDGSRMAEQYYTHDNNGTNYVSLCHLINYHGRDYYFNGEQEWYRFFLDELNKQYDENNVFIADRPLAAQWPVVNMQTAAKKYLWLPTPHAVDPRDQVYSNLNNAYVYGLHEFLSAWDGVITSTEQQKQDLTQWLGGQPSVPILTISAAIVSKQQAQHAPISISERHAHEIIYTGRLDAERRVDQLVTAFDQVHHKITDATLVIYGYGGELDRLKQQVSQLHLETAVTFAGYQPNLTMAYDQAGAYVYTGESDAQPLSLIEALSHGVPAIAYDINYGPKDVLKDGKNGYLVTDGAVNQLVRALTRTLESPQRQQRLSKGAYRSSEQYSDEQVWKQWQPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU8</accession>
    <name>F9URU8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase, with LysM peptidoglycan binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URU8"/>
    <dbReference type="EnsemblBacteria" id="CCC79937">
        <property type="protein sequence ID" value="CCC79937"/>
        <property type="gene ID" value="CCC79937"/>
    </dbReference>
    <dbReference type="GeneID" id="57026202"/>
    <dbReference type="KEGG" id="lpl:lp_2845"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2379"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077123_0_0_9"/>
    <dbReference type="OMA" id="RMWVANS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2434-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394308" evidence="2">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="30708" checksum="10A85C6ED5DD33C4" modified="2011-10-19" version="1">MKIKNALLTSLAATGLLALGTTVANADTVVVKAGDTVSEIALTHKTTIKAIQKANHLKNVNLIYIGDKLEVNGKHHATTVTTQVPTSAASSTASSTSTASSTANSTSTQSASSASVSSSTSTSAASTATSSSTTSVASSSAASSSSTSAASSSVTSTSTASAASSSAASSSTSSATSSSATSQASTASSSTATSASMTKLSNTTASSAASTSTAASSSATTSSSTTTSTSSSSSTTSTSSSAEAAAKAWIANKESGGSYTASNGNYYGKYQLSKSLLNGDYSASNQETVADEYVASRYGSWVAAKAFWEANGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US01</accession>
    <name>F9US01_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644859.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2913"/>
    <dbReference type="EnsemblBacteria" id="CCC79990">
        <property type="protein sequence ID" value="CCC79990"/>
        <property type="gene ID" value="lp_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2913"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2432"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_5_0_9"/>
    <dbReference type="OMA" id="SAYPEMW"/>
    <dbReference type="PhylomeDB" id="F9US01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2486-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="28578" checksum="BF2B224CBBDE0DE8" modified="2011-10-19" version="1">MTIKLIATDMDGTFLNDHGDYDQERFANDYAALQQRGIQFVIASGHQAAELATTFSAYPEMWLIGGNGAELWQREAGLKAATFSPQATQQVLAALAPYPELQVALCGTQTVHVLAHANPQFVANMRDYYYQLETCADLTTVTDPVVKFDVICPAAMTEQLVYELTPKLAGIAVPASGGQGSMDLIQPGMHKGRALKQLGEQLGILPDEMLVFGDGTNDLEMFHYATHAVAMQNAPENVQANATAVTGTNVDDGVLDYIEQHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9US09</accession>
    <name>F9US09_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">npp</name>
        <name evidence="1" type="ordered locus">lp_2922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="RefSeq" id="YP_004890512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2922"/>
    <dbReference type="EnsemblBacteria" id="CCC79998">
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        <property type="gene ID" value="lp_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2922"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2440"/>
    <dbReference type="eggNOG" id="COG1524">
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        <property type="component" value="Chromosome"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    <sequence length="447" mass="49878" checksum="D3F851CCD08FFB4A" modified="2011-10-19" version="1">MATNQHLVIISLDALGFRDLREHQAELPVLSGLMTGGTWVKSVTGIYPTLTYPSHTTIITGQYPSVHGIVNNTKLQPTRRSPDWYWYQKDVQVPTLYDLARQKKLTTAAFLWPVTAGSKITYNLAEIFPNRIWTNQVLVSLKASSPLFLLAMNHKYGHLRNGIKQPQLDEFITACAVDTLTNKKPNLTMIHLVDMDSMRHRYGVRSSEAMAALHRLDRHVGQLIDATKAAGTFADTNFVILGDHYQINVDHMIHLNTLFAQQGWLTARQDQTFEDDWSVMAKTADGSTYIYTRPEFDQLDELKALVSQVEGVETIITGEAAARRGADPACALMVEAQEGYYFTDESRRPTVVEPVHPATLGQPDRYHGVHGYDPTKPDYQTTLLFNGPAVKAGGTIETANLVDEAPTFARLLGLNFDGPMPGHCLDGVFKDQTKKRERGKAGGHQHH</sequence>
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        </submittedName>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890519.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2930"/>
    <dbReference type="EnsemblBacteria" id="CCC80005">
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        <property type="gene ID" value="lp_2930"/>
    </dbReference>
    <dbReference type="GeneID" id="57026276"/>
    <dbReference type="KEGG" id="lpl:lp_2930"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="EHELNHI"/>
    <dbReference type="PhylomeDB" id="F9US16"/>
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    <dbReference type="InterPro" id="IPR001633">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="226" mass="26122" checksum="5AE22996A24D193D" modified="2011-10-19" version="1">MYRFFVQPQVDHSHRAVFGYELLLRKEMNGHWAVPKSFTELSLDKQAELLEQLASQLQTKATNQVLALNLNRQQAEDDLMLGTIIYLKKRLNPAALTIELTECPSLNEIQKYSLFFHQHDIKLSIDDVGTGSNTFENIRHALPFVDQIKFAMQNLRMSGQAERIPHELAFWRDIAQSYHLEFILEGVEDQGDQKMAEQQGIEWHQGYYYGKPRLVDDGRQLVNGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9US61</accession>
    <name>F9US61_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp1</name>
        <name evidence="8" type="ordered locus">lp_0036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC77608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0036"/>
    <dbReference type="EnsemblBacteria" id="CCC77608">
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        <property type="gene ID" value="lp_0036"/>
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    <dbReference type="GeneID" id="57026894"/>
    <dbReference type="KEGG" id="lpl:lp_0036"/>
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    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="PhylomeDB" id="F9US61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-30-MON"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="27061" checksum="DF669D1AA0D41CA4" modified="2011-10-19" version="1">MKKILVVDDEKPISDIMKFNLTKEGYEVHVAADGEEALQKVDEVHPDLILLDLMLPKMDGLEVARQVRKNYDMPIIMVTAKDSELDKVLGLELGADDYVTKPFSNRELVARVKANLRRQGTPSAQPAEVEENSDIEIGDLVIHPEAYMVSKRGENIELTHREFELLHYLAQHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKVEDNPSHPKWLVTRRGVGYYLRNPENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9US95</accession>
    <name>F9US95_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase/esterase, subfamily of SGNH-hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2960"/>
    <dbReference type="EnsemblBacteria" id="CCC80025">
        <property type="protein sequence ID" value="CCC80025"/>
        <property type="gene ID" value="lp_2960"/>
    </dbReference>
    <dbReference type="GeneID" id="57026297"/>
    <dbReference type="KEGG" id="lpl:lp_2960"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102134_0_0_9"/>
    <dbReference type="OMA" id="IAVNQQT"/>
    <dbReference type="PhylomeDB" id="F9US95"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2521-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="233" mass="25483" checksum="54F683F054876669" modified="2011-10-19" version="1">MKHQKLIYWLVGIFAVVFIGGALIIPTPTIKQQVVSIGNAITGNTKTKGATHAVSDSALGEKYQLSTSEIHVLRKLKVTGIGDSIMVRTTSDLKQIFDHFNVNAKVGRQVSEAPAVISQLKADNAIQKNVLINLGTNGPTSAAEIDGIIDQIGSNHQIYWVNTRVPGKDWQDPNNQLIAAAAKKYNNVHLIDWLYVAQDNDNWFVKDNLHPNSLGEREYTATVGQTMAKTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA7</accession>
    <name>F9USA7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101989.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890551.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2975"/>
    <dbReference type="EnsemblBacteria" id="CCC80037">
        <property type="protein sequence ID" value="CCC80037"/>
        <property type="gene ID" value="lp_2975"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2975"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2482"/>
    <dbReference type="eggNOG" id="ENOG5032BQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541624_0_0_9"/>
    <dbReference type="OMA" id="SNANDTM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2533-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394407" evidence="1">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="502" mass="53080" checksum="C114C8CA4B8CCA15" modified="2011-10-19" version="1">MKRLRHIKLGMLLLSCLAFISMLAITSQAAAPVTSATTTIANSSNKYYTYFNSGDVVGFNISGGIGIYPSLTKVTANYADQGRISTKTTIITLTFSGSLFANSSEIKTLYYDVFYKQATEEFGTSLVTKTPTNMATGSSTVSMNTSKTLTVDMSKLKDNLPVYIGFRLTTVKGETSTYRLAVFNRISLNTTLNTPTTTDTTLTGTRIAGNTVSTTINGKSYTATIGSDGKYEIKLNDGLSGVTSVTVTQTGEADYGESESVTKDVTIPPLTIKSSSTAVNLSVSDLAALTSDSDAVNWLVKQAGVVATNPSNANDTMTYHASESGLVALFKGLADNQSTAVHIYATSASGLTSDKIALQVTKLAGTLSFGQLTTNMSFGDLKVPLTPQVYQPTNPLAISVTDTRATGAKWYLYVSATPLTSTTVSGRTLKGDLVYRDGSAQTVLTNQATLVQQGQKVAGTTDTVVTDDWSTTKGIGLSAQPGIYADTYQGTLSWTLSDTPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK5</accession>
    <name>F9USK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, subgroup 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890649.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3091"/>
    <dbReference type="EnsemblBacteria" id="CCC80135">
        <property type="protein sequence ID" value="CCC80135"/>
        <property type="gene ID" value="lp_3091"/>
    </dbReference>
    <dbReference type="GeneID" id="57026401"/>
    <dbReference type="KEGG" id="lpl:lp_3091"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2581"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_9"/>
    <dbReference type="OMA" id="KSTMVAT"/>
    <dbReference type="PhylomeDB" id="F9USK5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2628-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="32626" checksum="0E7CA4CAD36E2549" modified="2011-10-19" version="1">MKIAMLGSLGNINRIVVPKLVQAGHDVTVISTSPKRQASIEAIGAHAAIGTMTDVDFLSTTFTDKDVVYLMLSGGIGDDPFEGAVAQAKIWKQAIENAGVTNVVNLSSIGADADEVAGSLHAYNLIEHELRQLDGVNLAFVRPTGFYANLFGNLATIKAEHKIYSSTPAASAQKYVAPEDIASVVYPLIDHTPAGITVKYAFSDTFTGDQFVADLRDALNMPDLQWVQISDEQYQANLTNHGVPVKIAASLVQTSRYQREPEGLYADLNASDTSAGQVKLADFVRTFVVAYNSEGGYQSHTIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USN1</accession>
    <name>F9USN1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642363.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890675.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063797"/>
    <dbReference type="EnsemblBacteria" id="CCC80161">
        <property type="protein sequence ID" value="CCC80161"/>
        <property type="gene ID" value="lp_3119"/>
    </dbReference>
    <dbReference type="GeneID" id="57026427"/>
    <dbReference type="KEGG" id="lpl:lp_3119"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2608"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107548_0_0_9"/>
    <dbReference type="OMA" id="MANIYTP"/>
    <dbReference type="PhylomeDB" id="F9USN1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2654-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="25319" checksum="7BA5A8F5FEC0442E" modified="2011-10-19" version="1">MANIYTPSQKAAKRQAIMTAAINLFAHRSYPEITMQQIAEAVGSSKGATFRYFTTKEDLFMTILLEDYQQYFTQLTTDLAQQPPLSADDFIAWLTTQTRQLIEEHSVLIRLNAIRGPILEGKANMQETITQREALYRASQRLGQQLVIQTDHLLDQSQFSHLFIIQSGIISGLINMAALTSFNHHKLSVDYPDFEIRLIPEAQQQIRYYLTQYLKEFSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9USW1</accession>
    <name>F9USW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888206.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77692">
        <property type="protein sequence ID" value="CCC77692"/>
        <property type="gene ID" value="lp_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="57026979"/>
    <dbReference type="KEGG" id="lpl:lp_0141"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.116"/>
    <dbReference type="eggNOG" id="ENOG5030A9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164689_0_0_9"/>
    <dbReference type="OMA" id="LVECCMA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-114-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394419" evidence="2">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="270" mass="28645" checksum="6793EE0AB34C954B" modified="2011-10-19" version="1">MKKLTSVVATLALALPLAASPFAMTTTANAATVTPKATTHALTKATHFPAITMHAKAATTLNTIHFAADRAIAFVSPAKAKLSTKKTYTVTKTITLATGKHTSATYYLISEHGKALGWAKATTMIKGNAPTAKLKATKKTPKTKLTITKKTTKQAGPKATSAKKATPKIKASKKVIKLTKQTTTKAKSTKLTIKHPKASIKPTKKVTTLATKKTLAQPTKTKKMAPQLIKKTAKQNAKKAPKLATKKHLTVKTTTKHTPSKLTPKAAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT12</accession>
    <name>F9UT12_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgm1</name>
        <name evidence="1" type="ordered locus">lp_0205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646364.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888257.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0205"/>
    <dbReference type="EnsemblBacteria" id="CCC77743">
        <property type="protein sequence ID" value="CCC77743"/>
        <property type="gene ID" value="lp_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0205"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.169"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="DWYLQAP"/>
    <dbReference type="PhylomeDB" id="F9UT12"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-165-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23057" checksum="FCE58C1B92F4B5F8" modified="2011-10-19" version="1">MTTFYVVRHGQTVANAQNLKQGTINTAVTHLNSVGKQQAQTLHDTFDISFADRLICSPLDRTQATAAILNQGRQLPVSQDERLLEISYGQWDGQDNDQLLAAYPQYFDPLLQDVLPSYVEVATDGETFEHVQQRVAAFLKTTAQAHPDEQIIVVTHGFTVKAMALAILKPTDPMSLPEPANTSVTKVMVDAVHGRQYLAYYNRLPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT42</accession>
    <name>F9UT42_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641832.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0243"/>
    <dbReference type="DNASU" id="1061383"/>
    <dbReference type="EnsemblBacteria" id="CCC77773">
        <property type="protein sequence ID" value="CCC77773"/>
        <property type="gene ID" value="lp_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="57027063"/>
    <dbReference type="GeneID" id="66448350"/>
    <dbReference type="KEGG" id="lpl:lp_0243"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.200"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_9"/>
    <dbReference type="OMA" id="QFRDMKD"/>
    <dbReference type="PhylomeDB" id="F9UT42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-195-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="50691" checksum="050A5D0838891D25" modified="2011-10-19" version="1">MPPLDLTHIRQHHTVAELIALGKARRQVTPFEKLGTFTPVKRNASDYLKHVREMLVPELLPLRRERMSASAFAFFRGSVELMDYDLDYQSSTEIPAVVCGDAHIGNFGFYASPERRLVFDLNDFDEAGVHPWEWDLRRLLVSVLLAARDSNFKPKKVEKLIQAASASYREALKRMFDQTTLDRFYRDNEVQAVLNFGGAPEDTADLIASLVKKAQKRNSEQVVRKFTVTNSRGERQFKENAPRSVHIDRQTYQGLKAGISEYLLNVRTDVALLLSQYEVTDIIRHSVGVGSFGSLCYLVLLTSTDGSHMVLQIKEALPTRKVGSQSRPALTAAMELTEGQRIVSSQRILQATSDAFLGYFQMENKSFYVRQFRDMKESIDIPTLDWGQFQAYANTCAMILAKAHAQSPTAAMIRGYVGNSAKFDEAMAKWATAYVEQVDNDYQDFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT52</accession>
    <name>F9UT52_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Serine acetyltransferase</fullName>
            <ecNumber evidence="4 10">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysE</name>
        <name evidence="11" type="ordered locus">lp_0254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100940.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0254"/>
    <dbReference type="EnsemblBacteria" id="CCC77783">
        <property type="protein sequence ID" value="CCC77783"/>
        <property type="gene ID" value="lp_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0254"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.210"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_1_9"/>
    <dbReference type="OMA" id="ANCIVLE"/>
    <dbReference type="PhylomeDB" id="F9UT52"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-205-MON"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="180" mass="19208" checksum="DC23F1DE03442421" modified="2011-10-19" version="1">MFQTARAILNRDPAAINLRTVMLTYPGIHALAWYRVAHYFETHRLPLLAALLSQHAARHTGILIHPAAQIGHRVFFDHGIGTVIGATAVIEDDVTILHGVTLGARKTEQAGRRHPYVCRGAFIGAHAQLLGPITIGANSKIGAGAIVLDSVPAHVTAVGNPAHLVATQLHAYHEATSNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT84</accession>
    <name>F9UT84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, DUF20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3171"/>
    <dbReference type="DNASU" id="1064024"/>
    <dbReference type="EnsemblBacteria" id="CCC80202">
        <property type="protein sequence ID" value="CCC80202"/>
        <property type="gene ID" value="lp_3171"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3171"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2650"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053149_0_0_9"/>
    <dbReference type="OMA" id="KFFQHPG"/>
    <dbReference type="PhylomeDB" id="F9UT84"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2690-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="360" mass="41526" checksum="629B9D63594E0748" modified="2011-10-19" version="1">MDFVEFWSQLIRNVRWRRACVLALIVLTLYLASSMMSIILLTFIFTFLVTRLVRAVRRWVKIPPTIIVLVVYALVILGIYFAVSIYLPQLIKQTFLTFESVYRFYQNPSHDTNQVLTWVTSYFQESDILKQLKGGISVVFQYITNIGNMGLTFFLSFILSFFFTIEDHQMRVFTKRFLTSTFGWFFQDVHFFAKKFVNSFGVVLEAQFLIAIVNTVITVTFMAILKMPQLISLGLMIFILSLIPVAGVIISVVPLSLIAYSVGGLRYVVYMLLMILVVHALEAYVLNPKFMSSRTELPIFYTFVVLLVSERLFGVWGLIVGVPIFNFILDIIGVKPVHRPRPNINLKKTITFHPDSENKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA3</accession>
    <name>F9UTA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine 5'-monophosphate (IMP) dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">guaB</name>
        <name evidence="6" type="ordered locus">lp_3194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642427.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890735.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3194"/>
    <dbReference type="EnsemblBacteria" id="CCC80221">
        <property type="protein sequence ID" value="CCC80221"/>
        <property type="gene ID" value="lp_3194"/>
    </dbReference>
    <dbReference type="GeneID" id="57026483"/>
    <dbReference type="KEGG" id="lpl:lp_3194"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_0_9"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="PhylomeDB" id="F9UTA3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2709-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="5">
        <location>
            <begin position="12"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="383" mass="39906" checksum="E2285BD3C7248EAD" modified="2011-10-19" version="1">MSNWDTKFGKKGYTFDDVLLIPAESHVLPNEVNLGVKLADNLQLNIPIISAGMDTVSESAMGIAMANQGGLAVIHKNLSIEAQAEEVKKIKAVVKDDDHPHAAVDANNHLLAVAAVGVTSDTFDRAEALFAAGADAIVIDTAHGHSAGVLRKIKEIRAHFPKQTLIAGNVATAEGTRALFEAGVDVVKVGIGPGSICTTRIVAGVGVPQLTAVYDSASVAREYGKAIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTAEAPGEVVFDDGRQYKFYRGMGSVGAMSQAHGSSDRYFQGGVNEANKLVPEGVEGRVPFKGSVDDIIFQMLGGLRSGMGYVGAKDIDALIENAQFVEISGAGLRESHPHEIQITKNAPNYSVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB8</accession>
    <name>F9UTB8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3214"/>
    <dbReference type="EnsemblBacteria" id="CCC80236">
        <property type="protein sequence ID" value="CCC80236"/>
        <property type="gene ID" value="lp_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3214"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2684"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_5_9"/>
    <dbReference type="OMA" id="FDKSEPY"/>
    <dbReference type="PhylomeDB" id="F9UTB8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2724-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388143" evidence="4">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="48"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="29330" checksum="9F6E9453963590F4" modified="2011-10-19" version="1">MKKWLKAVSLTILGLALTVALTACGNSSSSKSSTSSTSSQLKLQKSDTLTIGLEGTFQPYSYRKDGKLTGFEVDLGKAVAKKLGLKAKFVPTKFDSLIAGLDVDKYDVVINDIAETAQRKQKYLFSTPYIYSKSELAVKKGSSINKITDIKGKKVAQTTTSNNATDAKRLGATVTPTDGFQQSIDLVNQGRVAGTINSREAFYAYLKQNPKASLKFISGGSEIKTQKIGAIVTKKHAPLQKQLSKAIQELRQDGTLKKLSNKYFGGNVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF5</accession>
    <name>F9UTF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890787.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3259"/>
    <dbReference type="EnsemblBacteria" id="CCC80273">
        <property type="protein sequence ID" value="CCC80273"/>
        <property type="gene ID" value="lp_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3259"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2721"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_9"/>
    <dbReference type="OMA" id="VQHATAY"/>
    <dbReference type="PhylomeDB" id="F9UTF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2761-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="232" mass="25237" checksum="2826F2BF0766D773" modified="2011-10-19" version="1">MFYSFFDPTYLLVIIGLIISMAASGYVNRTFRHYDAYRSQSGTTGTDAARFILSQSGINDVGVQKISGDLTDNYNGQTKILSLSEATADSTSVAAIGVAAHECGHAVQDHVNYWPMRLRTALVPITNIGSSLSLPLIIIGVLLSYNQTLIHIGILLFSLALLFQLVTLPVEFNASRRALQILSDGQVLTRDEVPMVRKVLVAAALTYVAAALSTFLQLLRLIILFGGNRDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL2</accession>
    <name>F9UTL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3337"/>
    <dbReference type="EnsemblBacteria" id="CCC80330">
        <property type="protein sequence ID" value="CCC80330"/>
        <property type="gene ID" value="lp_3337"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3337"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2880283_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="63" mass="7088" checksum="12CBB124277BDFE0" modified="2011-10-19" version="1">MAVKIVTLCGSRKYAAVFETVELALSKQGVIVLKPAFSDEVLTPIELQNLRQTHLKKSTWQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL5</accession>
    <name>F9UTL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface hydrolase, DUF915 family,membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890847.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3341"/>
    <dbReference type="ESTHER" id="lacpl-LP.3341">
        <property type="family name" value="Duf_915"/>
    </dbReference>
    <dbReference type="DNASU" id="1063922"/>
    <dbReference type="EnsemblBacteria" id="CCC80333">
        <property type="protein sequence ID" value="CCC80333"/>
        <property type="gene ID" value="lp_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3341"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2785"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_0_0_9"/>
    <dbReference type="OMA" id="KEPSIAR"/>
    <dbReference type="PhylomeDB" id="F9UTL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2822-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="33481" checksum="805B420A4995E2DF" modified="2011-10-19" version="1">MMKRWRTVIQLLLIVFVIGAAVILVGARNHDTKITKVTSQLTPRSARILKNQYDQSKTATVFLHGYNGGAYSTNYLIRKAEKAGAAQKALVVHVYKNGVMAFKGYWQKSIKNPMVQVVFQDNHASQKAQIYWLHQVLVQLKAKYGVKAYNAVGHSLGANDIVNQALKYGHDKRLPTLNKIVTIGGPFDGLTGFLSTQTEATVRRLDVKPSRFTKHFSEMLKYRHNFPDNVKLLNVYGDTNTGYNNDGFVGVASARSIRYLLRGKLTQYQEAFYSGEQAAHCALNQNPSVAHKMIAFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT6</accession>
    <name>F9UTT6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepD2</name>
        <name evidence="6" type="ordered locus">lp_0334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888370.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0334"/>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="CCC77856">
        <property type="protein sequence ID" value="CCC77856"/>
        <property type="gene ID" value="lp_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0334"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.284"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_4_2_9"/>
    <dbReference type="OMA" id="TAFVPYY"/>
    <dbReference type="PhylomeDB" id="F9UTT6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-278-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="470" mass="52974" checksum="2718CF44829B11BA" modified="2011-10-19" version="1">MYEQACTTILVGKKATVDGSTMIARNDDTFMPITPQKFIVHPAVHGRNETLTSGKNGFTAPLPADGYRYQAVPNIEVAEKGVFEENGFNEKNVGVSSTESVYGNEHTLTFDPFVPNGLAEDSLPTMLTPFIDSARGGVEYLGQLIAKYGSPEGNGVLFNDKDDVWYMEIVTGHHWVAQRIPDDAYAVAANQVAIQWVDFDDPDNFMWSDGIQEFVAEHHLNPDKEGFNFRHIFGTDNEKDRHYNTPRVWYGQRYFNPEIEQDPQSSELPFICHAAKKISVADVEFVLGSHYNETKYDPFLNTPEAKKFRPISMNRTQNSHVMQVRNDVPAEQSAIMWMTFGVPAFAPYLPFHANVSETDPSFANTPLKHDMNSAYWLYRTLSMIVESHYADFVQDDIDYLKECRIELGQFVAATDEQAAKLSGDELTAFLTEQDKVMVAKMRDKAQALIGQLVTKGLTLSKLTYNVDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTU1</accession>
    <name>F9UTU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LL-diaminopimelate aminotransferase, AAT family, PLP-dependent</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapC</name>
        <name evidence="3" type="ordered locus">lp_0339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888375.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0339"/>
    <dbReference type="EnsemblBacteria" id="CCC77861">
        <property type="protein sequence ID" value="CCC77861"/>
        <property type="gene ID" value="lp_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0339"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.289"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_9"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="PhylomeDB" id="F9UTU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-283-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="42801" checksum="C3E764905F706127" modified="2011-10-19" version="1">MKFEESKILQQLPKQFFANLVKKVNAKAAAGADVINLGQGNPDQPTPEFVVKAMQTATANPADHKYSLFRGLPRFKQAAADFYEREYGVKLDPETEIAVLGGSKIGLVELPFALLNPGDTMILPDPGYPDYLSGITLAQVKLALLRLTAANHFLPDYQQVDPQVAAAAKLLYLNYPNNPTGAVATSQFFQDTVDFANEHQIGIVHDFAYGAIGFDGQRPVSFLQTPGAKDVGIEMYTLSKSFNMAGWRVGFAAGNADMIEALNLIQDHLFVSVFPAIQDAAIAALNSDQQTVHELVRLYERRRNQFFTTARKIGWEPYPSGGSFYAWMPVPEGYTSEAFADLLLDKAAVAVAPGNGFGAGGEGYVRVGLLIDEPRFTEACQRIAKLHLFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ8</accession>
    <name>F9UTZ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plantaricin biosynthesis protein PlnO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnO</name>
        <name evidence="2" type="ordered locus">lp_0411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888432.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0411"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77918">
        <property type="protein sequence ID" value="CCC77918"/>
        <property type="gene ID" value="lp_0411"/>
    </dbReference>
    <dbReference type="GeneID" id="57024216"/>
    <dbReference type="KEGG" id="lpl:lp_0411"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.337"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684731_0_0_9"/>
    <dbReference type="OMA" id="ATSEWIY"/>
    <dbReference type="PhylomeDB" id="F9UTZ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-341-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="399" mass="46848" checksum="4753B1A641BB9A82" modified="2011-12-14" version="1">MIKFKERGNVSFSNFRLKEHQCDYEPIIGLIMVKNQERRILQTLESIVNICDQIIMVDTGSSDNTVAIVESNYNSVLIKHVDWKEDYAAMRNKCLTFVPNDTWVLFVDSDEIFSKEYNSEEIKSFLYEVDKRFPNQDKICTVKQMQPDRPTYVRPERFVKKTETLYYFGYVHEEPRTKRTEKLVKIDTDLELMNNGLTKGEYAKFNKQQRYAMLLKKNIALEPDNPRWTSLISPIDIQLGLFEHDKYVEKLKKEILKDIHGDITENNVKQGEYLNYLLERYCIELVHSENMELASKYIKFSKKKFPYDVTFIVLEMTIFFTSLEQASLRELKKIIDFTNNTDFNIIDSESEGSEDALSAVVIKLLLLVEKFDQAKAVYKTISDPIAKELLNDEKKILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU50</accession>
    <name>F9UU50_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator of CopAB ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">copR</name>
        <name evidence="2" type="ordered locus">lp_3365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890866.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3365"/>
    <dbReference type="EnsemblBacteria" id="CCC80352">
        <property type="protein sequence ID" value="CCC80352"/>
        <property type="gene ID" value="lp_3365"/>
    </dbReference>
    <dbReference type="GeneID" id="57026615"/>
    <dbReference type="KEGG" id="lpl:lp_3365"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2805"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_1_9"/>
    <dbReference type="OMA" id="WTLGEAT"/>
    <dbReference type="PhylomeDB" id="F9UU50"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2841-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014071">
        <property type="entry name" value="Cu_transp_CopY/TcrY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02698">
        <property type="entry name" value="CopY_TcrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="142" mass="15682" checksum="75A5CF8908C1E94D" modified="2011-10-19" version="1">MEAQTKIEISDAEWEVMRVAWTLGNVTSSQVAEIMADKMGWKTATVKTLLGRLVKKGALRAEKNGRAFNYYPMVEEQPSMDEAVDTLFGHLCQMRVGQTLVDLVNQTELSQTDIAALQAVLAEKAKDAPEMVDCDCVPGTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU64</accession>
    <name>F9UU64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102134.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3381"/>
    <dbReference type="EnsemblBacteria" id="CCC80366">
        <property type="protein sequence ID" value="CCC80366"/>
        <property type="gene ID" value="lp_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3381"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2817"/>
    <dbReference type="HOGENOM" id="CLU_1658590_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2854-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="17678" checksum="B39AF7B5E2C96649" modified="2011-10-19" version="1">MKWEPIKLLRDVPNSSGRLLIKFTNYFGFDRCAWYERPYSFAKLLAGQHSYNAGYEFDTPRFNSRWLDHGELYKVNGTSLVVAVGHNYGPYEDIIKCATDVAQPLGLRAIVYDRAVDWYYPNETVLVVYMADETFKRYEHKLLSFASVEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU74</accession>
    <name>F9UU74_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3391"/>
    <dbReference type="EnsemblBacteria" id="CCC80376">
        <property type="protein sequence ID" value="CCC80376"/>
        <property type="gene ID" value="lp_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3391"/>
    <dbReference type="HOGENOM" id="CLU_2898617_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="62" mass="7185" checksum="B6E55A7ABC55B769" modified="2011-10-19" version="1">MVHFWCNCGAFYLCPIVSYYTQKLIKRCYTGYFESHCGSLSVAIQSYLTKLVNCTKLKFALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD8</accession>
    <name>F9UUD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ram1</name>
        <name evidence="2" type="ordered locus">lp_3471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUD8"/>
    <dbReference type="STRING" id="220668.lp_3471"/>
    <dbReference type="CAZy" id="GH78">
        <property type="family name" value="Glycoside Hydrolase Family 78"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80440">
        <property type="protein sequence ID" value="CCC80440"/>
        <property type="gene ID" value="lp_3471"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3471"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2888"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415466_0_0_9"/>
    <dbReference type="OMA" id="YMRFYEL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2928-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="249"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="652" mass="74761" checksum="5221E5EB06DCFE9F" modified="2011-10-19" version="1">MLMSKEAVWLWYPGDFEIHQGMLQNFKREERGMGWPAYWYIDDCNRNVNFKRHYDLKESTQFTVLAKGTGYVDVNGTKYRLNHAINCDAGATDIQVFVGNVQGLPTIYIVGEIIKSDSGWLASNFVTTLPAGHDILYTDRNQDPNGIEYRTEKVVAKAQQAVDGGVLYDFGRAVNGTVTVKTNGPVTLCYGESETEARDVEMCYYKQSDVTATTKVRKRAFRYVFVPHCQLGDIELTAMHEYIPKNNPSSFTSDNKLINQIWNVATETLNLCSDLFFIDGIKRDRWIWAGDAYQANFINQYSFFNEDIDKRTLLALRGQDDIKQHMNTIVDYSMLWVIGVLNHYQMTGDREFLKIIYPKLESMVQYFIQQTNEHGFIYGRKNDWIFVDWSEMDKQGTVAAEQILLLEDYKTIMTCGEVLGKDVAGYQAKYDQLFKNLMKYFWDDEQGAFIDSYESGKRHVTRHANIFAILFDVVDENKQQLILKNVLLNNAITQITTPYFKFFEQDALCKLGEQHRVYQVLLDYWGGMLDRGAVTFWEEFDPSQHGKDMYAMYGDPYGKSLCHAWGASPIYLLGRHFVGLRPTAPGYQTFEIKPELSEFHHLHTVLPIKGGTVTVVKDQHQLSVTASRAGGTLIVDGQRQSLEPNRTAVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE5</accession>
    <name>F9UUE5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator. LacI family, galactose related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galR</name>
        <name evidence="5" type="ordered locus">lp_3479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890961.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3479"/>
    <dbReference type="EnsemblBacteria" id="CCC80447">
        <property type="protein sequence ID" value="CCC80447"/>
        <property type="gene ID" value="lp_3479"/>
    </dbReference>
    <dbReference type="GeneID" id="57026693"/>
    <dbReference type="KEGG" id="lpl:lp_3479"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2895"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_1_2_9"/>
    <dbReference type="OMA" id="VYTEFMG"/>
    <dbReference type="PhylomeDB" id="F9UUE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2935-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="335" mass="38222" checksum="C637B54320866A82" modified="2011-10-19" version="1">MTMAVTLKDIAQRADVSLATVSRVLNYDKTLSVSEQTRKRVFTIAGELRYSKRKRQHIKALMRKNIAVIQWYSKIQEHDDLYYLAIRKGIEHQAQVCGFTTTSIFQNNLDQVGDDIDAIVAVGKFSPVQVQQLSRLSSQLVFVDDDHFAQGFSSVVTDFTFATNRVVDYFWRRGIRDIGMIYGKEWSTDQQVEIPNQRQQSFEQALQRHHAYHAEYVLAGDYTSQSGYLMMKRAIEMLGDRLPHAFFIANDPMAAGALKALQQADIAVPQRVKLFSFNNTTLAEYVYPEISSVNVETELMGKTAIDLLVSRFQDDRQAAQRIELGTTLVERESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH3</accession>
    <name>F9UUH3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts29C</name>
        <name evidence="11" type="ordered locus">lp_3507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643568.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890989.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3507"/>
    <dbReference type="EnsemblBacteria" id="CCC80475">
        <property type="protein sequence ID" value="CCC80475"/>
        <property type="gene ID" value="lp_3507"/>
    </dbReference>
    <dbReference type="GeneID" id="57026720"/>
    <dbReference type="KEGG" id="lpl:lp_3507"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2923"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_0_9"/>
    <dbReference type="OMA" id="ITILWSV"/>
    <dbReference type="PhylomeDB" id="F9UUH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2963-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="7"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="445" mass="48275" checksum="A37CF0815A4D26F7" modified="2011-10-19" version="1">MDNSRTWKDKTIDVMSKIAANRYLRAIRDGMAVIIPVTIVGSFFTIVTQLPITAWTNFIKPYAAGLAIPINFSMGFMAIYAAFAIAGRLAEDYHFDHISTGVVSVMVFLLLAVKPITTTPAAFKALGLKAAATVVPLTHFGAAGLFTAMLAGILTAEVTRICRDHHLVITLPDGVPPAVAASFSALIPATFLIVGAWVIHVGLNFDVNAFLQWVFSPLAYFGRDNLLSVIVPILLTDIVWLFGIHGAALATPIFWPLWYPNLNDNLAAISKGATAATVPHFMTEQFFQWFVYIGGAGATLSLCILLAFFSKSAYGKTIGRVTIIPGIFNINEPVIFGVPIVMNPYFAIPFVLAPLTMGIITWAATVLHLVSRTVALVPWTLPGPIGALMTTAWDWRAAVLCIINIIVATFIYYPFFKIWDRNQLKAEQDAAKADAEKAAQAAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ0</accession>
    <name>F9UUJ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbg10</name>
        <name evidence="6" type="ordered locus">lp_3526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891006.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3526"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80492">
        <property type="protein sequence ID" value="CCC80492"/>
        <property type="gene ID" value="lp_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3526"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2940"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="EYMNRYF"/>
    <dbReference type="PhylomeDB" id="F9UUJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2980-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="487" mass="55355" checksum="446FBF7C3DEDDF13" modified="2011-10-19" version="1">MYSKTMPTGFPKNFLWGGATAANQVEGGWNVDGKGLTTAEVVQKATDRKVMSMNEVTKESVQAAIDDQTDKLYPKRRGVDFYHHYKEDIKLFAEMGFKVYRLSLAWARIFPKGDETEPNEAGLKFYDNVFAECHKYGIEPLVTISHYEMPLNLTLTNNGWASRKTIADFTRYTEVLFKRYKGVVKYWLTFNEINASTWGFTGTGAIDSDLSLHDQMQLRYQALHHEFVASAIAVKQCHEIDPEAQIGSMLARMQTYANTPNPADVRAAQLQDQLNLFFTDVQVRGEYPEYMNRYFAENGIELTMEAGDEQLLAEGKVDYLSFSYYMTTITSATDDVEQASGNLSMGGKNPYLKSSAWGWQIDPVGLRITLNEFWDRYRVPLFVVENGLGAEDEISADGKIHDDYRIDYLRQHIEQMKEAVKDGVDLMGYTTWGCIDVISAGTSEMSKRYGFIYVDQDDEGNGSLKRMKKDSFDWYKKVIASNGEDLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>P96349</accession>
    <accession>F9US59</accession>
    <name>CSP2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Cold shock protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cspL</name>
        <name type="ordered locus">lp_0031</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="3039" last="3042">
            <title>Cloning and characterization of cspL and cspP, two cold-inducible genes from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Mayo B."/>
                <person name="Derzelle S."/>
                <person name="Fernandez M."/>
                <person name="Leonard C."/>
                <person name="Ferain T."/>
                <person name="Hols P."/>
                <person name="Suarez J.E."/>
                <person name="Delcour J."/>
            </authorList>
            <dbReference type="PubMed" id="9139925"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>LP80</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>In response to low temperature.</text>
    </comment>
    <dbReference type="EMBL" id="Y08940">
        <property type="protein sequence ID" value="CAA70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643615.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888120.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96349"/>
    <dbReference type="SMR" id="P96349"/>
    <dbReference type="STRING" id="220668.lp_0031"/>
    <dbReference type="EnsemblBacteria" id="CCC77606">
        <property type="protein sequence ID" value="CCC77606"/>
        <property type="gene ID" value="lp_0031"/>
    </dbReference>
    <dbReference type="GeneID" id="57026891"/>
    <dbReference type="GeneID" id="66448184"/>
    <dbReference type="KEGG" id="lpl:lp_0031"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.28"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_9"/>
    <dbReference type="OMA" id="FEIQDGH"/>
    <dbReference type="PhylomeDB" id="P96349"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-27-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000100306" description="Cold shock protein 2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CSD">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="66" mass="7300" checksum="933C202684587579" modified="1997-05-01" version="1">MKNGTVKWFNADKGFGFITGEDGTDVFVHFSAIQTDGFKTLDEGQKVTYDEEQGDRGPQATNVQPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q06115</accession>
    <accession>F9UUJ8</accession>
    <name>CBH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conjugated bile acid hydrolase</fullName>
            <ecNumber evidence="3">3.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Bile salt hydrolase</fullName>
            <shortName>BSH</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Choloylglycine hydrolase</fullName>
            <ecNumber evidence="3">3.5.1.24</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbh</name>
        <name type="synonym">bsh</name>
        <name type="ordered locus">lp_3536</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Appl. Environ. Microbiol." volume="58" first="3792" last="3798">
            <title>Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay.</title>
            <authorList>
                <person name="Christiaens H."/>
                <person name="Leer R.J."/>
                <person name="Pouwels P.H."/>
                <person name="Verstraete W."/>
            </authorList>
            <dbReference type="PubMed" id="1476424"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>DSM 4229 / 80</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of animals, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in the bile salts glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a preference for glycine-conjugated bile acids as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycocholate + H2O = cholate + glycine</text>
            <dbReference type="Rhea" id="RHEA:19353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29746"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="EC" id="3.5.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycodeoxycholate + H2O = deoxycholate + glycine</text>
            <dbReference type="Rhea" id="RHEA:47552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23614"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:82982"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chenodeoxycholate + glycine = glycochenodeoxycholate + H2O</text>
            <dbReference type="Rhea" id="RHEA:47112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:36234"/>
            <dbReference type="ChEBI" id="CHEBI:36252"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:47114"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cholate + taurine = H2O + taurocholate</text>
            <dbReference type="Rhea" id="RHEA:47108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
            <dbReference type="ChEBI" id="CHEBI:36257"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:47110"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + taurodeoxycholate = deoxycholate + taurine</text>
            <dbReference type="Rhea" id="RHEA:47556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23614"/>
            <dbReference type="ChEBI" id="CHEBI:36261"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + taurochenodeoxycholate = chenodeoxycholate + taurine</text>
            <dbReference type="Rhea" id="RHEA:16309"/>
            <dbReference type="ChEBI" id="CHEBI:9407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:36234"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:16310"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">0.22 mM for glycodeoxycholate</KM>
            <Vmax evidence="3">1.56 umol/min/mg enzyme with glycodeoxycholate as substrate</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="3">Optimum pH is 4.7-5.5.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 30-45 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text evidence="6">Lipid metabolism; bile acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer. The tetramer consists of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="3"/>
    <dbReference type="EC" id="3.5.1.24" evidence="3"/>
    <dbReference type="EMBL" id="S51638">
        <property type="protein sequence ID" value="AAB24746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M96175">
        <property type="protein sequence ID" value="AAA25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A48953">
        <property type="entry name" value="A48953"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891014.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q06115"/>
    <dbReference type="SMR" id="Q06115"/>
    <dbReference type="STRING" id="220668.lp_3536"/>
    <dbReference type="MEROPS" id="C59.951"/>
    <dbReference type="PRIDE" id="Q06115"/>
    <dbReference type="EnsemblBacteria" id="CCC80500">
        <property type="protein sequence ID" value="CCC80500"/>
        <property type="gene ID" value="lp_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3536"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2947"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_1_9"/>
    <dbReference type="OMA" id="HYAIIGI"/>
    <dbReference type="PhylomeDB" id="Q06115"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2988-MON"/>
    <dbReference type="BRENDA" id="3.5.1.24">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00221"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047742">
        <property type="term" value="F:chenodeoxycholoyltaurine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045302">
        <property type="term" value="F:choloylglycine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006699">
        <property type="term" value="P:bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000073020" description="Conjugated bile acid hydrolase">
        <location>
            <begin position="2"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>deoxycholate</name>
            <dbReference type="ChEBI" id="CHEBI:23614"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>deoxycholate</name>
            <dbReference type="ChEBI" id="CHEBI:23614"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>taurine</name>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB24746/AAA25233." evidence="5" ref="1">
        <original>S</original>
        <variation>P</variation>
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB24746/AAA25233." evidence="5" ref="1">
        <original>S</original>
        <variation>N</variation>
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P54965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="1476424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="1476424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="1476424"/>
        </source>
    </evidence>
    <sequence length="324" mass="37042" checksum="B5E53F74AD742347" modified="2007-01-23" version="4">MCTAITYQSYNNYFGRNFDYEISYNEMVTITPRKYPLVFRKVENLDHHYAIIGITADVESYPLYYDAMNEKGLCIAGLNFAGYADYKKYDADKVNITPFELIPWLLGQFSSVREVKKNIQKLNLVNINFSEQLPLSPLHWLVADKQESIVIESVKEGLKIYDNPVGVLTNNPNFDYQLFNLNNYRALSNSTPQNSFSEKVDLDSYSRGMGGLGLPGDLSSMSRFVRAAFTKLNSLSMQTESGSVSQFFHILGSVEQQKGLCEVTDGKYEYTIYSSCCDMDKGVYYYRTYDNSQINSVSLNHEHLDTTELISYPLRSEAQYYAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD8</accession>
    <name>Q6LWD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf39</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133753.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723589"/>
    <dbReference type="EnsemblBacteria" id="CAG17870">
        <property type="protein sequence ID" value="CAG17870"/>
        <property type="gene ID" value="CAG17870"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17870"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3116"/>
    <dbReference type="eggNOG" id="ENOG5030A6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185202_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3170-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="69" mass="7990" checksum="C7A37E6B76402EEB" modified="2004-07-05" version="1">MSQSNLEKQEAKLKALNQKIKDEKNKIEQRLGKQIISQANLDYANLSNDQIKLLAKQFSEFLKVKSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE4</accession>
    <name>Q6LWE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222040.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133747.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723583"/>
    <dbReference type="DNASU" id="3125600"/>
    <dbReference type="EnsemblBacteria" id="CAG17864">
        <property type="protein sequence ID" value="CAG17864"/>
        <property type="gene ID" value="CAG17864"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17864"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3111"/>
    <dbReference type="eggNOG" id="ENOG503369B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260806_0_0_9"/>
    <dbReference type="OMA" id="SKNMTTK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3164-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="24820" checksum="A46D4A76CCC85064" modified="2004-07-05" version="1">MRLKKSKTANKSVKLDWDYQPPKINGGKETIDDMSLVVGMYGNYEVTKTGNLVGILEVSGINLDLLNETEQQDVFEDYGAFLMSTLGEGVDDTLQFLEPTIPVNMTTYLNGLKRRYLALQKDHPEQQFKIQLIASYLDHFTKVQESKNMTTKQHLLIVKVPIKDKSAESLNLAVAHLDEKIEQVKRDIENALTDFDVTAKILTSQEVQEILKNLINFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF3</accession>
    <name>Q6LWF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traL</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133738.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723574"/>
    <dbReference type="EnsemblBacteria" id="CAG17855">
        <property type="protein sequence ID" value="CAG17855"/>
        <property type="gene ID" value="CAG17855"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17855"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3102"/>
    <dbReference type="eggNOG" id="ENOG5033FP4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083594_0_0_9"/>
    <dbReference type="OMA" id="TWANIIM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3155-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="31636" checksum="BD753C103639D747" modified="2004-07-05" version="1">MFVLGDISGLVQGAIAKFFEWALSGLLDGLFNICKAIIDQANQSLPIVKTWYAIFLSFATSLVVVVVLGRIVMTILKEADESTDVTWANIIMDGIKSAAVIPVFVFLQGFIQGSITLPLLKYMFSSDQKFTAKSITGMNKVPGLKDVGISLPLQILFLLIFTVVTVVFFIKMCVFVADMAWYNLTIPLAAMSMATESFDYSGTWWKKYIYYNASIISQVLCMSLSVWCFTNMAKYGFIAFIASIGFGFLVVKTPDAVKDFWASTGVTKSAGMGAMRMFQNYFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH6</accession>
    <name>Q6LWH6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orf1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222012.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133715.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723551"/>
    <dbReference type="EnsemblBacteria" id="CAG17832">
        <property type="protein sequence ID" value="CAG17832"/>
        <property type="gene ID" value="CAG17832"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17832"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAKLQIS"/>
    <dbReference type="PhylomeDB" id="Q6LWH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3132-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="93" mass="10412" checksum="78EC341955BE1E86" modified="2004-07-05" version="1">MAVKEKKRVQVKIDKDLADDTEAVLSELGLNPTTAINMFYKRIVANGALPFNASLTEEERANLRFLKATEGTPVTEFKDAKEVADWLNDPDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-12" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S51</accession>
    <accession>F9ULE7</accession>
    <name>RHAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-rhamnose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaA</name>
        <name type="ordered locus">lp_3593</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-rhamnose and L-rhamnulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102237.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S51"/>
    <dbReference type="SMR" id="Q88S51"/>
    <dbReference type="STRING" id="220668.lp_3593"/>
    <dbReference type="EnsemblBacteria" id="CCC80554">
        <property type="protein sequence ID" value="CCC80554"/>
        <property type="gene ID" value="lp_3593"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3593"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2998"/>
    <dbReference type="eggNOG" id="COG4806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052790_0_0_9"/>
    <dbReference type="OMA" id="HKVNLHA"/>
    <dbReference type="PhylomeDB" id="Q88S51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3041-MON"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01748">
        <property type="entry name" value="rhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="chain" id="PRO_0000090557" description="L-rhamnose isomerase">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <sequence length="427" mass="48699" checksum="E5E67EBB39B8044C" modified="2003-06-01" version="1">MVKTDEVEKAYQVAKERYAEIGVDTEKAMEALKKVKLSVHCWQGDDIHGFLNPDQELTGGIGVSGDYPGIARTPDQLTGDLHEALSLIPGSHKVALHTLYAVTDKKKDFNEVGPEDFKYWVDWAKQEGIGLDMNPTFFSHPMVKHNFTLASPEKSVRDYWIEVGKKSREIANYFGQELGQQSVNNFWIPDGFKDNPIDKQAPRERLIESLDEVFAKKYDEKNTIEAVEGKLFGTGIESYTVGSHLFYNNYAISRGKLWTIDAGHWHPTEDVSDKFSAFMPFGKGLMLHVSRPIRWDSDHVVIFDEALQRITRSLVRDNELERTNIGLDFFDATINRVSAWVIGARATQKALLQAMLAPIDDLKKAELNYDFTKRLAVTEELKSFPFGAVWDEFCLKNNTPVGTDWLDEIHNYEQKVQFPRDKKVVTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SV6</accession>
    <accession>F9UTG3</accession>
    <name>PURA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">lp_3270</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890795.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SV6"/>
    <dbReference type="SMR" id="Q88SV6"/>
    <dbReference type="STRING" id="220668.lp_3270"/>
    <dbReference type="EnsemblBacteria" id="CCC80281">
        <property type="protein sequence ID" value="CCC80281"/>
        <property type="gene ID" value="lp_3270"/>
    </dbReference>
    <dbReference type="GeneID" id="57026544"/>
    <dbReference type="GeneID" id="66450808"/>
    <dbReference type="KEGG" id="lpl:lp_3270"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2730"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_9"/>
    <dbReference type="PhylomeDB" id="Q88SV6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2769-MON"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000095189" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="429" mass="47236" checksum="96DDE293F74BF867" modified="2011-11-16" version="2">MASVVVVGSQWGDEGKGKITDFLSQEADVVSRYQGGDNAGHTIVFNGQTFKLRLIPSGIFFHDKLAVIGNGVVLNPKSLVEELQYLRDKGVNPDNLRISNRAHVILPYHITLDGAQEKAKAGGKIGTTNKGIGPAYMDKAERIGIRVADLLDKDTFAALLKRNLAEKNQIITKLYDLEPLKFEDIFDDYYAYGQTLKPFVTDTSVVINDALDNGQRVLFEGAQGVMLDIDQGTYPYVTSSNPVAGGVTIGSGVGPSKIDNCVGVLKAYTSRVGDGPFPTELFDEVGDFIRETAHEYGTVTKRPRRIGWFDSVVLRHAKRVSGFTHLSLNCLDVLTGLKTIKVCTAYDLNGETIYHYPASLKELEACKPIYEELPGWDEDITGVKTFEELPTNAQNYLRKLEELVGVKIATFSVGPDREQTNVIDHNIWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU2</accession>
    <accession>F9UQR4</accession>
    <name>ATPG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">lp_2365</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU2"/>
    <dbReference type="SMR" id="Q88UU2"/>
    <dbReference type="STRING" id="220668.lp_2365"/>
    <dbReference type="EnsemblBacteria" id="CCC79553">
        <property type="protein sequence ID" value="CCC79553"/>
        <property type="gene ID" value="lp_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2365"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1998"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_9"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="PhylomeDB" id="Q88UU2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2037-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000073300" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="314" mass="34522" checksum="A87122049FCB3FC1" modified="2003-06-01" version="1">MAESLMDVKRRIDSTKKTHQITSAMQMVSTSKLNQIQKHTSTYQVYASKVESIVSHLAKAHLMSASAGVANSNSNTISVSELLAQRPVKKTGLLVITSDRGLVGSYNSNVLKQTNDFMRTHKVDADNAVVLAVGGTGADFYKKNGLNVAYEYRGVSDVPTFKEVREIVKTVTSMYHNEVFDELYVFYNHFINRLSSGFRAVKMLPISEETFEQSESDNRKAKDSRVDVGPEYEMEPSEEAILSAVLPQYAESLVYGAILDAKTAEHASSSTAMKAASDNAGDLIDKLNLKYNRARQAAITTEITEITGGLVAQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V02</accession>
    <accession>F9UQK4</accession>
    <name>RUVA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">lp_2287</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890007.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V02"/>
    <dbReference type="SMR" id="Q88V02"/>
    <dbReference type="STRING" id="220668.lp_2287"/>
    <dbReference type="PRIDE" id="Q88V02"/>
    <dbReference type="EnsemblBacteria" id="CCC79493">
        <property type="protein sequence ID" value="CCC79493"/>
        <property type="gene ID" value="lp_2287"/>
    </dbReference>
    <dbReference type="GeneID" id="57025829"/>
    <dbReference type="KEGG" id="lpl:lp_2287"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1935"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_1_0_9"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="PhylomeDB" id="Q88V02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1977-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000094642" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="203" mass="21665" checksum="DBE55EDD9C7EB0C7" modified="2003-06-01" version="1">MYEYFLGQVTDVTPGYVVIEVSGIGYKVLTANPYRYQVGPTAVKMYIHQAVSENGMSLFGFFDADEKALFEKLLGVSGIGPKSALAILANNDHAGLIQAINQENATYLTSFPGVGKKTAQQIVLDLKGKLNDLNVDVTGQTALDVDAPAVDGALADALAALEALGYSKADVKKVTKKLETFSQTQGADTNTLLSEGLRLLMKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V33</accession>
    <accession>F9UQH3</accession>
    <name>Y2253_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein lp_2253</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2253</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889976.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V33"/>
    <dbReference type="SMR" id="Q88V33"/>
    <dbReference type="STRING" id="220668.lp_2253"/>
    <dbReference type="EnsemblBacteria" id="CCC79462">
        <property type="protein sequence ID" value="CCC79462"/>
        <property type="gene ID" value="lp_2253"/>
    </dbReference>
    <dbReference type="GeneID" id="57025799"/>
    <dbReference type="GeneID" id="66450011"/>
    <dbReference type="KEGG" id="lpl:lp_2253"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1905"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_3_0_9"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="PhylomeDB" id="Q88V33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1947-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000175827" description="Probable transcriptional regulatory protein lp_2253">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="242" mass="26430" checksum="8CCF6B8FCDE56A9B" modified="2003-06-01" version="1">MSGHSKWHNIQGRKNAQDAKRGKVFQKISRELYMAVKAGGPDPDSNAQLRLVMDKAKAANMPKDNIKRAVDKGSGSGAENYEEVTYEGYGPGGIAVLVHALTDNKNRTAAAVRSAFTHHGGALAATGAVSYMFDRKGYIVISREDLDTDEDTMLMDVLDAGGDDLQSSDEAFEIYTDPKQLAAVRDALEANGYKLETAELTMIPENLTDVPADKVEKLQHMIDELEDNDDVSEVYEAANYPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V61</accession>
    <accession>F9UQE6</accession>
    <name>NADK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">lp_2222</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889949.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V61"/>
    <dbReference type="SMR" id="Q88V61"/>
    <dbReference type="STRING" id="220668.lp_2222"/>
    <dbReference type="EnsemblBacteria" id="CCC79435">
        <property type="protein sequence ID" value="CCC79435"/>
        <property type="gene ID" value="lp_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2222"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1877"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_9"/>
    <dbReference type="OMA" id="NGIERMS"/>
    <dbReference type="PhylomeDB" id="Q88V61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1896-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120626" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="267" mass="29825" checksum="3D48E7004676EE7E" modified="2003-06-01" version="1">MKVTIFANASAKTKKVAGELHTKLLAAGFEIDDEHPDIVLSVGGDGTLLAAFHHYSHMVDQVRFVGVHTGHLGFYTDWRDYEIDQLINGLLEDNGQSVTYPLLAVDITYADTDATDHYLALNESTLKKLGSTMVADVYIQDELFERFRGDGLCVSTPTGSTAYNKSVGGAVIHPRLDALQMAEIASINNRVFRTLGSPVIVAPYETITIRPQQQSHFVFTADQMDTQPRPIEQIRYSIANRRIAFAQHRHNRFWQRVGTSFIGLDEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VE3</accession>
    <accession>F9UQ62</accession>
    <name>ENGB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">engB</name>
        <name type="ordered locus">lp_2115</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640795.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VE3"/>
    <dbReference type="SMR" id="Q88VE3"/>
    <dbReference type="STRING" id="220668.lp_2115"/>
    <dbReference type="PRIDE" id="Q88VE3"/>
    <dbReference type="EnsemblBacteria" id="CCC79351">
        <property type="protein sequence ID" value="CCC79351"/>
        <property type="gene ID" value="lp_2115"/>
    </dbReference>
    <dbReference type="GeneID" id="57025657"/>
    <dbReference type="KEGG" id="lpl:lp_2115"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1792"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_9"/>
    <dbReference type="OMA" id="LMMDIRH"/>
    <dbReference type="PhylomeDB" id="Q88VE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1812-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000157757" description="Probable GTP-binding protein EngB">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <sequence length="197" mass="22377" checksum="F760C12288F4B076" modified="2003-06-01" version="1">MEVHNVELVMSAVAPSQYPTTGFPEIGLAGRSNVGKSSLINVLINRNSYARTSSQPGKTQTLNFYKVEDQLYFVDVPGYGYAKVSKKEREKWGQMIETYLTSRETLRGVVILVDARHAPTKDDVAMYEWMRYYEMPLLVVATKSDKIPRGKWNKQESLIKKTLNFQAEDDFIAFSAKTKEGKDAVWQWIEAHTVGGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VY3</accession>
    <accession>F9UPM2</accession>
    <name>Y1894_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0756 membrane protein lp_1894</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1894</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0756 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640601.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889675.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VY3"/>
    <dbReference type="STRING" id="220668.lp_1894"/>
    <dbReference type="EnsemblBacteria" id="CCC79161">
        <property type="protein sequence ID" value="CCC79161"/>
        <property type="gene ID" value="lp_1894"/>
    </dbReference>
    <dbReference type="GeneID" id="57025487"/>
    <dbReference type="GeneID" id="66449719"/>
    <dbReference type="KEGG" id="lpl:lp_1894"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1597"/>
    <dbReference type="eggNOG" id="COG2707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125889_1_0_9"/>
    <dbReference type="OMA" id="SKGINWG"/>
    <dbReference type="PhylomeDB" id="Q88VY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1623-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01874">
        <property type="entry name" value="UPF0756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007382">
        <property type="entry name" value="UPF0756_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38452">
        <property type="entry name" value="PTHR38452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04284">
        <property type="entry name" value="DUF441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000388895" description="UPF0756 membrane protein lp_1894">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01874"/>
        </source>
    </evidence>
    <sequence length="152" mass="16032" checksum="09F994A738F8C903" modified="2003-06-01" version="1">MESWLFLLAILVVAWLGKNQSLQIATVVVLLIKLIPNTSKLLTTIGQKGINWGVTVITVAILIPIATGQIGFRDLWHAFKSPVGWIAVACGVLVSVLSFHGVGLLSATPEITVALVFGTIMGVVLLKGIAAGPIIAAGITYCIIQVLHLSLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W02</accession>
    <accession>F9UPK3</accession>
    <name>CCA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCA-adding enzyme</fullName>
            <ecNumber evidence="1">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cca</name>
        <name type="ordered locus">lp_1873</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W02"/>
    <dbReference type="SMR" id="Q88W02"/>
    <dbReference type="STRING" id="220668.lp_1873"/>
    <dbReference type="EnsemblBacteria" id="CCC79142">
        <property type="protein sequence ID" value="CCC79142"/>
        <property type="gene ID" value="lp_1873"/>
    </dbReference>
    <dbReference type="GeneID" id="57025469"/>
    <dbReference type="KEGG" id="lpl:lp_1873"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1579"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_3_0_9"/>
    <dbReference type="OMA" id="MRAVRFM"/>
    <dbReference type="PhylomeDB" id="Q88W02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1604-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01263">
        <property type="entry name" value="CCA_bact_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023068">
        <property type="entry name" value="CCA-adding_enz_firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0692">RNA repair</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000139040" description="CCA-adding enzyme">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01263"/>
        </source>
    </evidence>
    <sequence length="407" mass="45140" checksum="19EC58046F577264" modified="2003-06-01" version="1">MILTQLPAEFQAAKPIIETIEAAGYEAYFVGGCVRDTILGKPLHDVDIATSAFPAEVKQLFKRTVDTGIEHGTVMILDHGNGYETTTFRTESGYQDFRRPDQVTFVRSLKEDLKRRDFTINALAMTANGEVIDLFDGLADMEQGILRAVGVAEERFHEDALRMMRAVRFASQLGFTIESQTEQAIADNAALLAKIAVERTRVEWEKLLMGQHPVAGLTGLLTTDLYRYMPAMADQEAMLRQLMALPAWHLPSIESTWTLLSWTMQRTDEAAVRQLLKTWKTSNELINHVTAAIKALMALKHNGQLTAQENFYTGLEALKTANQVATILGFGQDQAQLVQSYASLPIHDKHELAINGGDLLKAKLVTPGPMMGQILAACLQAVVMKQVPNQQDALLDFARMVADSKNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WG0</accession>
    <accession>F9UP43</accession>
    <name>ACCD2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2</fullName>
            <shortName evidence="1">ACCase subunit beta 2</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta 2</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD2</name>
        <name type="ordered locus">lp_1679</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889496.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WG0"/>
    <dbReference type="SMR" id="Q88WG0"/>
    <dbReference type="STRING" id="220668.lp_1679"/>
    <dbReference type="EnsemblBacteria" id="CCC78982">
        <property type="protein sequence ID" value="CCC78982"/>
        <property type="gene ID" value="lp_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1679"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1418"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_1_9"/>
    <dbReference type="OMA" id="PEGLWIK"/>
    <dbReference type="PhylomeDB" id="Q88WG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1445-MON"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000389767" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01136"/>
        </source>
    </evidence>
    <sequence length="281" mass="30944" checksum="106364969B3A54ED" modified="2003-06-01" version="1">MMPKRKFQAPTERQLAVRRDNIPDALLTRCPVCHEDCYTQDLGEFKVCPHCDYGFRLPAWQRVQQLTASFEERDADLSAPVSFDDPAYLEKLQRAKAASHLNESVLTGIGTLATYQFGLGVMETKFMMGSLGAATGEKITRLFETCTTQKLPVVMVTASGGARMQEGARALMQMAKVSTAVANHRKAGLLYITILTDPTTGGVTASFAMQGDIMLSEPRALIGFAGRRVIEQTIQQTPPADFQRAETLLANGWLDQIVPRPALRKTLQRLLTITQGGHQDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WR3</accession>
    <accession>F9UNT8</accession>
    <name>SYFA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">lp_1558</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644299.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889391.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WR3"/>
    <dbReference type="SMR" id="Q88WR3"/>
    <dbReference type="STRING" id="220668.lp_1558"/>
    <dbReference type="EnsemblBacteria" id="CCC78877">
        <property type="protein sequence ID" value="CCC78877"/>
        <property type="gene ID" value="lp_1558"/>
    </dbReference>
    <dbReference type="GeneID" id="57025147"/>
    <dbReference type="KEGG" id="lpl:lp_1558"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1311"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_9"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="PhylomeDB" id="Q88WR3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1338-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000126719" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="348" mass="39364" checksum="6A4CAA5486490CD0" modified="2003-06-01" version="1">MSLQDRLTELRDQGLADIKSADVLKKVNQVKVDLLGKKGPITEVLRGMRDLSPEERPKVGAYANEVRDRIQAAIDERREELEQAAVNEQLAAEKLDVTLPGREVPQGQPHVITQIITELEDLFMGMGYQIVDGDEVEEDYYNFERLNLPKDHPARDMQDTFYITKDVLLRTQTSADQPRSLENHDFSKGPLKVLSPGRVYRRDTDDATHSHQFHQIEGLVVDKHITMADLKGTLILVAKTLFGDQFDVRLRPSFFPFTEPSVEADVTCFNCNGKGCAICKQTGWIEVLGAGMVHPHVLEMSGIDPEEYGGFAFGLGPDRFAMLKYGVDDIRNFYLNDVRFLSQFYKKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY1</accession>
    <accession>F9UML0</accession>
    <name>RL22_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">lp_1039</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638065.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888963.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY1"/>
    <dbReference type="SMR" id="Q88XY1"/>
    <dbReference type="STRING" id="220668.lp_1039"/>
    <dbReference type="EnsemblBacteria" id="CCC78449">
        <property type="protein sequence ID" value="CCC78449"/>
        <property type="gene ID" value="lp_1039"/>
    </dbReference>
    <dbReference type="GeneID" id="49393322"/>
    <dbReference type="GeneID" id="57024696"/>
    <dbReference type="GeneID" id="66448952"/>
    <dbReference type="KEGG" id="lpl:lp_1039"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.876"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_9"/>
    <dbReference type="PhylomeDB" id="Q88XY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-892-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125167" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="115" mass="12481" checksum="706540A84538B041" modified="2011-11-16" version="2">MAEQVTSARATAKTVRIAARKVRLVVDLIRGKSVAEALAILKFTPRGASPVVEKVLLSAVANAENNFDLDREDLVVSEAFVNEGPTLKRFRPRAKGSASPINKRTSHITITVTEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YD2</accession>
    <accession>F9UM57</accession>
    <name>PPK1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyphosphate kinase</fullName>
            <ecNumber evidence="1">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppk</name>
        <name type="ordered locus">lp_0842</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="1">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641095.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888810.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YD2"/>
    <dbReference type="SMR" id="Q88YD2"/>
    <dbReference type="STRING" id="220668.lp_0842"/>
    <dbReference type="EnsemblBacteria" id="CCC78296">
        <property type="protein sequence ID" value="CCC78296"/>
        <property type="gene ID" value="lp_0842"/>
    </dbReference>
    <dbReference type="GeneID" id="57024538"/>
    <dbReference type="KEGG" id="lpl:lp_0842"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.716"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_9"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="PhylomeDB" id="Q88YD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-732-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000128646" description="Polyphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="1">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="718" mass="82227" checksum="9194E567F029D180" modified="2003-06-01" version="1">MNYYKESYYTNRELSWLDFNYRVLDEARDKDNPLLERVRFLGITQSNLDEFFTVRVASLRKLMSVNYTKPDPAGLTAADQVSAISDKAHEMVKRQYNTLNRSLLPLLEQHAIHLLSMADLNEEQHAFVKNYFDDELYPALTPMADDSSRPFPFIGNNTLNIALRIYKNGDKKDRKFATVQVPDVFPRVVVLPGAPNQFILIEEIIKAFVGSLFINYTVKETSCYRVMRDLDLDVAEEDTSDLLKEVQKQLKMRERGKVMRLEVEKSMSKHQRTRLAKALGINESALYVINGPLNLTFLSKLVKAVQGHEDLNYPKYHAYYPAKYRERSIFDLIKDHDILMQYPYDDFKPVVDFIHEAAEDEDVLAIKMTLYRVSADSPIIKYLGQAAQNGKQVTVLVEVKARFDEENNVHWAKKLEEMGCHVIYGLIGLKTHCKLALVVRRENEGIKRYMHMGTGNYNDVTAHFYTDMGLFTADTDMGIDASNIFNMLSGYSEPPYFHKLHISPDGIRDFINEKLDDEIAIAKAGQPAVVKMKMNSLSDPQIISKLYEASHAGVKIQLIIRGICCLRTGIKGISDNIEVHSIIGRLLEHSRIYYFSNDGEPQIYLSSADMMTRNLNRRVELLFPLLQPEISHRAMTIFETMWADTVKTRILQPDNTYARVDGRGLEVLDSQAEFIREAEQAVKADHGDTTPTSNAHQFIPMMSPKNEPDASDLDREDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z48</accession>
    <accession>F9UKZ3</accession>
    <name>HTPX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protease HtpX homolog</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpX</name>
        <name type="ordered locus">lp_0516</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101040.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888522.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z48"/>
    <dbReference type="STRING" id="220668.lp_0516"/>
    <dbReference type="EnsemblBacteria" id="CCC78008">
        <property type="protein sequence ID" value="CCC78008"/>
        <property type="gene ID" value="lp_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0516"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.425"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_2_1_9"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="PhylomeDB" id="Q88Z48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-429-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000138870" description="Protease HtpX homolog">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <sequence length="299" mass="32948" checksum="ECF66CEADBE19506" modified="2003-06-01" version="1">MLFEQIARNKRHTLYVMAAFVILLAVIGLAVGYVFFNSAIAGLLVALIAAVFYMVLMISQSTDIVMSMNHGRELHQADDDPELWHIVEDMALVAKVPMPRVFIIDDESPNAFATGNDPEHAAVAVTTGIQARLTREEMEGVIGHEMSHVRNYDIRLQTIALALTAAISLLVNWGMNAFWWGGGRRSRDNDRDGNGAQVLLMILAIVVIILAPLAASLVQMALSRNREYLADAGSVELTRNPLGLISALEKIDDSQPMQAADPSSAALYISDPFKAKKSWTHLFDTHPPMADRITRLKNM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZA0</accession>
    <accession>F9UU34</accession>
    <name>NPD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobB</name>
        <name type="ordered locus">lp_0449</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZA0"/>
    <dbReference type="SMR" id="Q88ZA0"/>
    <dbReference type="STRING" id="220668.lp_0449"/>
    <dbReference type="EnsemblBacteria" id="CCC77954">
        <property type="protein sequence ID" value="CCC77954"/>
        <property type="gene ID" value="lp_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0449"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.369"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_9"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="PhylomeDB" id="Q88ZA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-375-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110322" description="NAD-dependent protein deacetylase">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <sequence length="234" mass="26443" checksum="70B95DC2AF6CB65A" modified="2003-06-01" version="1">MSDITAAQTTLQQAQHIVFMTGAGVSTPSGIPDYRSKNGLYTEHHNAEYYLSHAFLAEHPLEFYQYLQSNLYYPDAQPNVIHQKMAALTQQGRASVITQNIDNLYGVAKTAQLVEFHGNLYQVYCTKCGQHVDWHEYLKSPYHQTDHGYLRPNVVLYDEGIASANIERAVQYLQQADLVVICGTSFRVYPFAGLIDYRNPKAQVLAINAEPLQLPFAFTMVQQDAVDFFEGVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL35</accession>
    <name>F9UL35_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.187</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tagA</name>
        <name evidence="3" type="ordered locus">lp_0564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1-&gt;4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:16053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:62959"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:132210"/>
            <dbReference type="EC" id="2.4.1.187"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; teichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.187" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888564.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0564"/>
    <dbReference type="CAZy" id="GT26">
        <property type="family name" value="Glycosyltransferase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78050">
        <property type="protein sequence ID" value="CCC78050"/>
        <property type="gene ID" value="lp_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0564"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.468"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_9"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="PhylomeDB" id="F9UL35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-480-MON"/>
    <dbReference type="UniPathway" id="UPA00632"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02070">
        <property type="entry name" value="TagA_TarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034714">
        <property type="entry name" value="TagA_TarA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="27892" checksum="89ED1E5346C80EF4" modified="2011-10-19" version="1">MSVPFDTVNILNVPFIKTTNAGFVQQLQTDILAHRNRFVVTANPEILMYAREHPNYQQVLTQADYITPDGIGVIQGAQILGTPLPERITGYDTLLTLLEWGSQQHQRIFLLGAKPAVLKQVTTIVQRDYPGIVVAGARDGYYDDEQTVVDQIVAAQPDMVFVATGFPKQEFFIAEHRQRLDALWMGVGGSFDVIAGAVKRAPLFWQKHHVEWLYRLIQEPSRFKRMLVLPRYLRLVKKIARQQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL91</accession>
    <name>F9UL91_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 5, superinfection exclusion (Cell surface N-anchored)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101079.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888620.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0628"/>
    <dbReference type="EnsemblBacteria" id="CCC78106">
        <property type="protein sequence ID" value="CCC78106"/>
        <property type="gene ID" value="lp_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0628"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.526"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796421_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-539-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011434">
        <property type="entry name" value="DUF1535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07553">
        <property type="entry name" value="Lipoprotein_Ltp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein_Ltp" evidence="3">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein_Ltp" evidence="3">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="348" mass="37935" checksum="A754C2B75FE6C5C6" modified="2011-10-19" version="1">MSKDNAEEYHRSYKAKKPFYKRVWFWALAVIVIFIVGGSLGGKDNSNATNNAGKTTSASDSQNTKVYSTQDLKVTVSKAIVHNTDWLIKGKTKAPNNSKIAAVIIDNSSDAITDIPISTSDDIKWAKVKDGNFSAYIEPLQAFNASKRHAGDTVTVYIVALENYEKKDTDTIPAHVRKQIKKTKPYTLTLTKAQADYQNSLDGSKKDSKKASSSSSKETSSSSNIDKNDDSESLSSSNSSTSSSKVSSEDKAALEKAQDYATEMNMSKQGVYEQLTSSAGEGFSSEAAQYAVNHLTDIDWNANALAKAKDYQSEMSMSRSAILDQLTSSAGEQFTQSQAQYAIDHLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD1</accession>
    <name>F9ULD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891052.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3576"/>
    <dbReference type="EnsemblBacteria" id="CCC80538">
        <property type="protein sequence ID" value="CCC80538"/>
        <property type="gene ID" value="lp_3576"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3576"/>
    <dbReference type="HOGENOM" id="CLU_216855_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3025-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="44" mass="4579" checksum="361D5AD392FDA0E7" modified="2011-10-19" version="1">MIKSILKFCLAAILIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK0</accession>
    <name>F9ULK0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system, glucitol/sorbitol-specific EIIB component and second of two IIC components</fullName>
            <ecNumber evidence="4">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pts38BC</name>
        <name evidence="4" type="ordered locus">lp_3653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3653"/>
    <dbReference type="EnsemblBacteria" id="CCC80607">
        <property type="protein sequence ID" value="CCC80607"/>
        <property type="gene ID" value="lp_3653"/>
    </dbReference>
    <dbReference type="GeneID" id="57026833"/>
    <dbReference type="KEGG" id="lpl:lp_3653"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3051"/>
    <dbReference type="eggNOG" id="COG3732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054195_0_0_9"/>
    <dbReference type="OMA" id="IQEDIYA"/>
    <dbReference type="PhylomeDB" id="F9ULK0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3094-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011638">
        <property type="entry name" value="PTS_EIIBC_GUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011618">
        <property type="entry name" value="PTS_EIIBC_GUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004702">
        <property type="entry name" value="PTS_sorb_EIIBC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39427">
        <property type="entry name" value="PTHR39427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07663">
        <property type="entry name" value="EIIBC-GUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03612">
        <property type="entry name" value="EIIBC-GUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00825">
        <property type="entry name" value="EIIBC-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51102">
        <property type="entry name" value="PTS_EIIB_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-5" evidence="3">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="339" mass="35787" checksum="B4E73F846B46B7D9" modified="2011-10-19" version="1">MAKEYHSIKVVKGSGGWGGPLIITPTITKHKFVYVTGGNKPAIVDKIAKLTGMEAVDGFKTSIPDEETALAVVDCGGTLRCGIYPKKGIKTINVLPTGKSGPLAQFMNEANYVSNVDVDQIMLVTSEEEQFSDSQNESANQFENVDDDTKFDNTKTLTAQTKNPGILTKIGIGAGRVVSTFNQAAKDAVQTVINTIIPFMAFVALIIGIINGSGIGKVFASIMEPLAGNVWGLMVLGFICSLPFLSPLLGPGAVIGQVIGTLIGVEIGKGNIPPQYALPALFAINTQNGCDFIPVGLGLAEADSKTVEVGVPSVLYSRFINGVPRVFIAWIASFGLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL4</accession>
    <name>F9ULL4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641611.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891135.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1061578"/>
    <dbReference type="EnsemblBacteria" id="CCC80621">
        <property type="protein sequence ID" value="CCC80621"/>
        <property type="gene ID" value="lp_3668"/>
    </dbReference>
    <dbReference type="GeneID" id="57026847"/>
    <dbReference type="KEGG" id="lpl:lp_3668"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3065"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_3_9"/>
    <dbReference type="OMA" id="TWTIRPP"/>
    <dbReference type="PhylomeDB" id="F9ULL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3108-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="160" mass="18409" checksum="520BE1A922BD4A92" modified="2011-10-19" version="1">MTKRIEIKPATAADQAALAEIYLVDRQQDFPWVTDPQLQDFNEDSRGEFVLVAWIDGQRAGFCSLYRLANFIHLLFVAPDFRHLKVGERLLTEMRQYATEPLTLKCVMANENALRFYAQVGFRIVKADADALPPNYTLRDTHTEQYVALVDVMANERKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL8</accession>
    <name>F9ULL8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sip3</name>
        <name evidence="8" type="ordered locus">lp_3675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891139.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3675"/>
    <dbReference type="EnsemblBacteria" id="CCC80625">
        <property type="protein sequence ID" value="CCC80625"/>
        <property type="gene ID" value="lp_3675"/>
    </dbReference>
    <dbReference type="GeneID" id="57026851"/>
    <dbReference type="KEGG" id="lpl:lp_3675"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3070"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_0_9"/>
    <dbReference type="OMA" id="ACDAYIK"/>
    <dbReference type="PhylomeDB" id="F9ULL8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3112-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22367" checksum="C12FF38FEB8163C1" modified="2011-10-19" version="1">MKTFKSIMSWVLPIVVGLLVAMVIRHFIFTMVRVDGPSMEPNLDDNERVAVVKTAKIQHLSVIVFNAYQVDPDARSKTVKYVKRVIGMPGDTVKSEDGRLYVNGKLVPQKFISQYERTQGTTNWDLSTLENRYSWNLKTTKVPKHSYFVLGDHRSVSNDSRYWGFVPANKVLGVVKVPFWDSNKTKRHNINSISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULY5</accession>
    <name>F9ULY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase/phosphodiesterase, EAL domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
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                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="PhylomeDB" id="F9ULY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-659-MON"/>
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            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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    </evidence>
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    </evidence>
    <sequence length="226" mass="26216" checksum="A8B61A3FD651763C" modified="2011-10-19" version="1">MYRYFIQPQLDKFNNSLIGYEMLIRYRETDQDRWTLPESFDNIPIDVQVSLLKATASELALKIGSVSINFNRKQFLNDDIAAAVIDAQKKLFPVHVIVEVTEEPGEDTFTLAAMQQQIDKYKTNGLQFSIDDVGTGINVYDHIKPLLESAEEIKFAMQNFRAEDRENEIPIQLKFWRDIAVRHDIRLILEGVENDAEDQMANDLNISLRQGYYYGKPHLFKLKADH</sequence>
</entry>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="331"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="470" mass="51518" checksum="A87FAE0438F1A941" modified="2011-10-19" version="1">MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFYSSPETLAKLGAMVRTKHNVLKIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPIFGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGTELSESYANTHHEVTLFQSHDQILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVGTGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATNAVRQGALAGANVFGNQQRYMGTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGNWRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSANALSIAIQNGNTIDDLAFVDMLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="832"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="987" mass="113058" checksum="6F39C21E6D3AB10A" modified="2011-10-19" version="1">MKNKQANQILRAWDLAEKISGGELDKKAKWFSGDIRKTAYQKRESGTINEKISQNNQSSDQHVTISLLYLGAYKKQDLRDSIQNIRFRDTEMVQNRDPAKGYSVALIVNSDWSFQKIEVPYAAYFYLKLRQENIEEAMHGQQYDDFKSQLSQQLEEVIDRKRADLAECLALANQIVLKTFKLAGTRNVGQFRGLFQIQDEPPMLNSFYTEDIERVLQASADDSLLLKYLGLNPDVATKQEVDQNRDFISKLLDVENLPDGRWPGPEKYFQSLMQQVAVNVIRDKGPIKTDLKTVNGPPGTGKTTLLQDVFADTIVQQAKVMAQLEKPMDGFRRIKPIELFSNCKYNAYELIPALQGYGIVVTSNNNSAVANISKEFPSRNKIRQYPNENREKQDEYRTQLEEIDYFSDLANRILETADSWGMFAVPMGSKANQRKVFKHINHGVLKKQLSVYSDSWADARQNFNTALEAVHQEKARLHRMISIVERANPSVVDQAYLELKVVDEGIEVLNQEIANLTQKIENTRHRLVTLPKKRFLIFWQHETPTHDSLRFHISNLNKKIEGLNERVADRRKERRHVVHLIAQQEKIIREVEPIQKQLKKEGIVVFNDDFWRQTNEKRQQALPNNSRVLQNKRARLFIAAMRLRKVFICEARVPISNAWEFFAHQDKLVFAEDTLALTAGFQIMQLLIPVMSTTLASVGRMFANFGENTIDNVYIDESGQATPASAVGIAWRAKHLVAIGDPAQIEPVVTTNEATLRTIARDFKVSEQYLLPTTSVQQLADQGSIYGMHRSNHTWVGIPLWVHRRCDSPMFEIANEISYENKMVQGKPTKLSQVERSRWINSKGKATNQQFVPENVTALARIMKKRRDEGKSLDQMFVISPFRAVVNGITNKLPKEFNDGAISKKWLQEHVGTVHRFQGKEADVVFLIIGTDQDTDGGADWAFSKPNLLNVAVTRARHDFYLIGDYHRLKSKPYAEVAARELPLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC8</accession>
    <name>F9UMC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asp1</name>
        <name evidence="3" type="ordered locus">lp_0929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644046.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888881.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0929"/>
    <dbReference type="DNASU" id="1061895"/>
    <dbReference type="EnsemblBacteria" id="CCC78367">
        <property type="protein sequence ID" value="CCC78367"/>
        <property type="gene ID" value="lp_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="57024608"/>
    <dbReference type="GeneID" id="66448867"/>
    <dbReference type="KEGG" id="lpl:lp_0929"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.787"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_1_1_9"/>
    <dbReference type="OMA" id="DGVHAMG"/>
    <dbReference type="PhylomeDB" id="F9UMC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-803-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="15786" checksum="A435E18526D80DEA" modified="2011-10-19" version="1">MAQPEQQLQTQLTFDDGVIEKIAGLASRNVDGVLSLEGGMLSNLTNRFRDEADPTQGVDAQVGKKQVALDMTMIVEYGKDMRQIFNQICQRVQQDVERYTGLKVIEIKVHVSDVMSKRDWQDQATGKPNTDQSTDKRQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD9</accession>
    <name>F9UMD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction-modification system,specificity subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS2</name>
        <name evidence="5" type="ordered locus">lp_0942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0942"/>
    <dbReference type="REBASE" id="7000">
        <property type="entry name" value="S.LplWORF939P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78378">
        <property type="protein sequence ID" value="CCC78378"/>
        <property type="gene ID" value="lp_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0942"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2035121_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-814-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="128" mass="14668" checksum="FCA3CAC8620FD3D5" modified="2011-10-19" version="1">MKLGDIVFTRTGASTGKTFIYRTADSIVYYAGFLIKMSVREDIDSEFVFQNTLTTSFNRFVKVMSQRSGQPGINSKEYARFKLYIPKLKEQVLVGNMLLLIDNLIAANEYNLKNALNIRGRFNLHLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME5</accession>
    <name>F9UME5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644056.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888898.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0949"/>
    <dbReference type="EnsemblBacteria" id="CCC78384">
        <property type="protein sequence ID" value="CCC78384"/>
        <property type="gene ID" value="lp_0949"/>
    </dbReference>
    <dbReference type="GeneID" id="57024625"/>
    <dbReference type="KEGG" id="lpl:lp_0949"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.806"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093421_0_0_9"/>
    <dbReference type="OMA" id="FNFNPDH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-820-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="28775" checksum="32F71948C4DCB004" modified="2011-10-19" version="1">MLLAALLKTRRCQYGLTQAQLASKLFVTTQAVSKWERGKAIPSIDNLLALSDLYNLSLDELVRGSAFFPKPYIVGRRLSFGRLLGLGLFWLFVCLLFTGFGYQPWWLFLSLYIVGLIVVVPVGINSYWVIQPATIELHTYAASTLTKFRQIVFNCPRCQLIHYTDLQRVTISYRCRKRFSPFDFNPDYFQLILKTNAQTYQLECALKASDYLPQFVSYLQRQGVTVDDPQQVVELLVSGKSLYQHFHTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMT9</accession>
    <name>F9UMT9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_1135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889042.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1135"/>
    <dbReference type="EnsemblBacteria" id="CCC78528">
        <property type="protein sequence ID" value="CCC78528"/>
        <property type="gene ID" value="lp_1135"/>
    </dbReference>
    <dbReference type="GeneID" id="57024774"/>
    <dbReference type="KEGG" id="lpl:lp_1135"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.959"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_3_1_9"/>
    <dbReference type="PhylomeDB" id="F9UMT9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-970-MON"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="34011" checksum="A01F0522C54BF68C" modified="2011-10-19" version="1">MKPKVFLEFVEIKSLIASVLPFVLGSMYAYYNYHQLHLGYLLLFFIASSLFHMATNANDNYQDFLHAPRNDDNQEFLQETNVVGVNQISIGQARTITFGLAGISLIIGLWLVTQTGLPLLWMGLYSYAVGYFYAGGPKPISQGPFGEFFSGFTMGFMIFWIAVFINTYDTAAITWQSTLAVLIASGLAIFAISNIMLANNICDMDEDIALGRHTILYYLGKPVMLQVFAWSYVAGYACLVIAVLMGVLPKFSLLTLLSIIPVWKNTRVFLHKQVKRETFTISIKNATLICLSFIVFMGLGLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ6</accession>
    <name>F9UMZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide biosynthesis protein,regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps2B</name>
        <name evidence="3" type="ordered locus">lp_1198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101299.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1198"/>
    <dbReference type="DNASU" id="1063111"/>
    <dbReference type="EnsemblBacteria" id="CCC78585">
        <property type="protein sequence ID" value="CCC78585"/>
        <property type="gene ID" value="lp_1198"/>
    </dbReference>
    <dbReference type="GeneID" id="57024830"/>
    <dbReference type="KEGG" id="lpl:lp_1198"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1016"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052027_2_4_9"/>
    <dbReference type="OMA" id="NPVSEQF"/>
    <dbReference type="PhylomeDB" id="F9UMZ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1028-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="26438" checksum="EB8F0561DC025420" modified="2011-10-19" version="1">MFKRKEQNITTTAPINLTTINEPMSVITEQIKTIRTNINFAATDHKLRTLMVTSAMLGEGKSTVSGNLAVEYAKEGMQVLLVDADLRRPTIHKTFGLKNHKGLSSWLANQMDDVNDAIHPVIGNLFVMTSGPKPPNPAELLGSNKMTEFLTSATRKLDLVIVDAPPILPVTDSQLLANKVDGTVLVVRQGVAQKAAVRDAVNSLKKSQANILGTVLNDVRDSSHHGYYGYNSGYGYYSDEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN16</accession>
    <name>F9UN16_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3E</name>
        <name evidence="2" type="ordered locus">lp_1221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101319.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889119.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1221"/>
    <dbReference type="EnsemblBacteria" id="CCC78605">
        <property type="protein sequence ID" value="CCC78605"/>
        <property type="gene ID" value="lp_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1221"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1035"/>
    <dbReference type="eggNOG" id="ENOG5030AZ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308839_0_0_9"/>
    <dbReference type="OMA" id="VIRGALW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1047-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="210" mass="23682" checksum="D555759E371BCF4C" modified="2011-10-19" version="1">MRHMKVQPKERFSLAWRWLPLELLIIMLSVGLGWAGNRWLPKPVYQASVDIQIAQTPRSGLSTARLKRQRRQDIKAITQFNVMPHQSAVLTQASTYAYAHYGIWQPIQELSESVQAAPVARRPVLRVTATSSSRQVAQQNAQAFNVAIKANLTGLKNYRVKTVKRTVTRETNVIRGALWKLILVVGGGLALLSPYLVKYGQGWGRHDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN42</accession>
    <name>F9UN42_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconokinase</fullName>
            <ecNumber evidence="4">2.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gntK</name>
        <name evidence="4" type="ordered locus">lp_1250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889145.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1250"/>
    <dbReference type="EnsemblBacteria" id="CCC78631">
        <property type="protein sequence ID" value="CCC78631"/>
        <property type="gene ID" value="lp_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1250"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1061"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_2_9"/>
    <dbReference type="OMA" id="SDAMHFK"/>
    <dbReference type="PhylomeDB" id="F9UN42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1072-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="504" mass="54496" checksum="797AAE296281FA51" modified="2011-10-19" version="1">MTYLIGTDLGTTSTKSVLYDHQGHVIASANVGYPLYHDTVTTAEEDPQEIWQAVQATIHQVSAGIDPEDIEGIAFSSAMHSLILLDSQKQPLTRVITWADNRAAQDAAELKSQPLGDRLYHLTGTPIHPMSPLVKLHWLAHHSPELLAQTCHVVGIKEYLIYKMTGQLQMDYSMANATGLFNLYNFDWEPVALDYAHITRTQLPPLVDTDAVIDGLTPVAASTLGLAPTMKIIMGASDGALSNLGVGADEPGVAAITIGTSGAVRVMTKQPYLDPEGRLFCYYVAPHHWIVGGPINNGGQVFRWVRDELFTTESQTARANQQDPYDQLTALAATVPVGAHGLLFHPYLSGERAPLWNADARGSLLGVTTTTTKADIARAVLEGIVMNLNTVLQLTAAAEPVHAIRATGGFARSSLWRQILTDVLGQPITIPASFESSCLAAAVIGLKALGHIDDLTAIHAMIGATETYQPNAANHQLYHQHQVVFDHVTAQLAPLYHEIATLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN46</accession>
    <name>F9UN46_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101334.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889149.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78635">
        <property type="protein sequence ID" value="CCC78635"/>
        <property type="gene ID" value="lp_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1256"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1065"/>
    <dbReference type="eggNOG" id="ENOG50344JZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033230_0_0_9"/>
    <dbReference type="OMA" id="PRNCELE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1076-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389014" evidence="1">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="54058" checksum="67F5DC0B23A4E96B" modified="2011-10-19" version="1">MRLKIRGRWLLGLMLGMGLWGPVTVHAATNLVRWPAVQSLAPRNCELESKQTRLYQLNRATMQLTPRGTARTTSHWQRVGQVMVTQNKRLVTYWQVRHGTAGRLSWALADTVRVVGTRVTDVKTPTRQPMRVVTTDQQEHGVTRAANKLSYLPLKGAERYTTEHILFRPTAAYLATQGLQNQPDTLRQSSGYRDHYHFKTALYLPQQLGSRLLNDPQSATFSADNRYLYVMYVNDQQLGGADQTGWVVRYDWQRLMALGAGQSGKMAMVRVAAAHQFDGKMTAFDRRVLAAIEVGPEFTAGHVQSLALNPKTNELWFISSTARDQLASVARLNPQSLTPDLKIAFTTGSGRLGDELTFDRAGQAYYWTHASQLRNGNVTLYRGTISSTTGVHFEQLAQGLANNPGFFAQSIGYNEVTGRLYLVSDESITSLPAAKLGHLTTSQVGEANFAGDREFEGLVFMHHSQEGFLLTNRGIELMRIIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA8</accession>
    <name>F9UNA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644245.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889211.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1341"/>
    <dbReference type="DNASU" id="1062685"/>
    <dbReference type="EnsemblBacteria" id="CCC78697">
        <property type="protein sequence ID" value="CCC78697"/>
        <property type="gene ID" value="lp_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1341"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1129"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_9"/>
    <dbReference type="OMA" id="ETDIQFM"/>
    <dbReference type="PhylomeDB" id="F9UNA8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1155-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="15321" checksum="84A3EBA2CFF208FD" modified="2011-10-19" version="1">MDDEVAKYTTQEISVLVGMSVSQVHYYDRLGLIPNLRRSENGYRVFTEKNLIWMKNLKIFIDSEMPLKDIRQLTDLVVQGKQATAEKRQAIVEHHLKELEKKQAELKKQVAFMNGFIKTYQQMEKESDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB2</accession>
    <name>F9UNB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889215.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1347"/>
    <dbReference type="DNASU" id="1062675"/>
    <dbReference type="EnsemblBacteria" id="CCC78701">
        <property type="protein sequence ID" value="CCC78701"/>
        <property type="gene ID" value="lp_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1347"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1133"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082354_0_0_9"/>
    <dbReference type="OMA" id="DHILENY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1159-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="31977" checksum="C975048CA23D60AB" modified="2011-10-19" version="1">MIKALNIVTKTGTELQGALFKAAHATTVLIAITGVHGNFYSNPFYVNIGKTLMAAGIDFIYAQTRDAFNQVVSLNHLTGKKELVGSWSEQFDDANEDIAAYLSYAEENQYQHIILGGHSLGANKVIYYLANHADVNVTKFLLLSPANLKRLTDMVSLSERNIIQKQIAAGNSNQLLPFELFGWLPCTAKTADQWLNSGILDNVHSDLRADFSQIERIRLSGAMVIGTLDTFTYGDPIKYLKTINAHFLSHAENDLVFIQKTGHTYQNKDQKLANEILKLIKNWSLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE0</accession>
    <name>F9UNE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfate sulfotransferase</fullName>
            <ecNumber evidence="2">2.8.2.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">astA</name>
        <name evidence="2" type="ordered locus">lp_1381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889243.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1381"/>
    <dbReference type="EnsemblBacteria" id="CCC78729">
        <property type="protein sequence ID" value="CCC78729"/>
        <property type="gene ID" value="lp_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1381"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1160"/>
    <dbReference type="eggNOG" id="ENOG502ZAQ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026701_0_0_9"/>
    <dbReference type="OMA" id="PANCYRA"/>
    <dbReference type="PhylomeDB" id="F9UNE0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1189-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047686">
        <property type="term" value="F:arylsulfate sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035391">
        <property type="entry name" value="Arylsulfotran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010262">
        <property type="entry name" value="Arylsulfotransferase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038477">
        <property type="entry name" value="ASST_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17425">
        <property type="entry name" value="Arylsulfotran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05935">
        <property type="entry name" value="Arylsulfotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Arylsulfotran_N" evidence="1">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="579" mass="64676" checksum="3D0C30994D0A5FA3" modified="2011-10-19" version="1">MKKRNWLIALIVVVIVAIGGGFGYYKYHQSTATTTTTSKVRSASATKKDINTRLVKTEIKAQSSETATLKKAVANKNYTVNNMYTKVNPYGVSPLSAKVIFQTSKAAKVSYTVVGKSSKTSISNTVNKYTTSHDLTVLGLYANTNNQVKIKVTYKDGTSTTKTIRLKTAKLPSALTDFKINVKKANKQKMVLGTGNSKLTFMVRTTISGSKQSKNLSFGMDADGNIRWYTTRPTSHIFKQLNNGHLLIWTKSNAKNSYFDELVEMDYTGKVYKTYKFNHKAWGKAKGSKKQNHNQVHHDVTELPNGDLIATVSDGGRTYVEDTMIVISHKTGKITKVINMKNILPAKFYTKYNATKSSKYMGKKDWFHQNSVYYDKTDKSLIISSRNQNLVMKIDYKTEKIKWILSGKKTSAWPKSYRKYLLKASGKIAWPGGQHAAIVDPSTLGKKNSLNVMIFNNNVAVGTTKKSLADSSGKYSEGVEYHINEKTKTISQVGSYGKSLGKKNFANIIGSNRYLSASNRLIDFGWLNNGKSANIIEYDLKSKQQVFNVELTGLPSGGYVYRAERFSLYPTKHTYGINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN9</accession>
    <name>F9UNN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase, gamma chain</fullName>
            <ecNumber evidence="15">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narI</name>
        <name evidence="15" type="ordered locus">lp_1500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="15"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101446.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889342.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1500"/>
    <dbReference type="EnsemblBacteria" id="CCC78828">
        <property type="protein sequence ID" value="CCC78828"/>
        <property type="gene ID" value="lp_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1500"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1262"/>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092378_0_0_9"/>
    <dbReference type="OMA" id="MVSGGFF"/>
    <dbReference type="PhylomeDB" id="F9UNN9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1289-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="26336" checksum="D42467EDEEDFB1A5" modified="2011-10-19" version="1">MKDFFSVILWVIYPYAMLLSFFVGTFVRLKFYPASVTAVSSEMLEKKKLMIGAITFHVGIILAFFGHILGILIPKAFTDFLGISDEMYHMFGSLMMGTGAGVLALAGMIILTYRRFTNVRVFVTSSWSDLMVNVALLITIILGLASTLSGPLHPAFDYRTTLSVWARSLFYLQPKWWLMATVPWIYKTHVICGLAIFGFFPYTRLIHAIAIPYQYFYRRYIVYRRRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS4</accession>
    <name>F9UNS4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-zinc-cadmium cation transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">czcD</name>
        <name evidence="7" type="ordered locus">lp_1540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101459.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889377.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1540"/>
    <dbReference type="EnsemblBacteria" id="CCC78863">
        <property type="protein sequence ID" value="CCC78863"/>
        <property type="gene ID" value="lp_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1540"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1297"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_5_9"/>
    <dbReference type="OMA" id="TINQIMW"/>
    <dbReference type="PhylomeDB" id="F9UNS4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1324-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="36095" checksum="2860F19C085FA0D9" modified="2011-10-19" version="1">MSIQRLPDWHQIEQPVVISLKTARHHLWGNVAVYLSLFIIELLGARWGHSQALRADAFNNLSGIFSTGLLMTGLFIASRTHDDDLFGAPIAPAEQQQLGPRIQQSRFRFETIFNLLAGTIMAAIGIDIIIKGVMTFATRTPFKNLSNIAGLAAGFSFVVLLVLWAFNHYWSRKLNNAALTAASRDTFTDALTSLTTVLTILVTVKLHLQWFDNLISIGLGLYILNTGTKIFRESSLNLVDYFDPYLEDRYQRRIADLTSVRKVIFLKAHYDGNLIMLRATIGVPPRMTAIEITRLIETINQIMWQEFGVMETDVMITTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV8</accession>
    <name>F9UNV8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine synthetase repressor, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glnR</name>
        <name evidence="2" type="ordered locus">lp_1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889411.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1580"/>
    <dbReference type="EnsemblBacteria" id="CCC78897">
        <property type="protein sequence ID" value="CCC78897"/>
        <property type="gene ID" value="lp_1580"/>
    </dbReference>
    <dbReference type="GeneID" id="57025167"/>
    <dbReference type="GeneID" id="66449465"/>
    <dbReference type="KEGG" id="lpl:lp_1580"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1331"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_9_0_9"/>
    <dbReference type="OMA" id="SIVMQLT"/>
    <dbReference type="PhylomeDB" id="F9UNV8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1358-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="126" mass="14552" checksum="A570DF4B34809161" modified="2011-10-19" version="1">MKEKELRRSLAVLPIGTVMKLTNLSARQIRYYEEQELITPERNAGNRRMFSLNDVDRLLEIKDYLADGINMAGIKEIYALQKQRAEQKQADLAKPLTDRDVRRILHDEFLNLGGLQSDKGPNYPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW1</accession>
    <name>F9UNW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1584"/>
    <dbReference type="EnsemblBacteria" id="CCC78900">
        <property type="protein sequence ID" value="CCC78900"/>
        <property type="gene ID" value="lp_1584"/>
    </dbReference>
    <dbReference type="GeneID" id="57025170"/>
    <dbReference type="KEGG" id="lpl:lp_1584"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1334"/>
    <dbReference type="eggNOG" id="ENOG5033W0S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887921_0_0_9"/>
    <dbReference type="OMA" id="FPSTHWV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1361-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="318" mass="35760" checksum="3C7D486BD09249A9" modified="2011-10-19" version="1">MANNTDKQMDTATLSTHGKLSTFNEGLKKGLANGEKFTALMDQLIDTTDGETLLAAAQQLADFKLDTAYVTFPHQYQNADYYLIFMSRLLGMHGDEQAVLNSQRHTEALYHVYGALTDDYTFLYQVVNNGNGGAYYREQTTGENLFYIHLERRLLRFNSSAFTNLFINKLLLKGTGVDQINTVLATLIKFGHCLQDDFGFNVDFNILDVANAAKYELRSANLDRAIVDKLFVSAAKNEHMLRNSQQGHGAQIELRAGLTVDIFDAAEAGGSQQWVLTVHDPDQAVSWFDVLLHFGFMRDWYLENIDSLEIKADPLVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW4</accession>
    <name>F9UNW4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889417.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78903">
        <property type="protein sequence ID" value="CCC78903"/>
        <property type="gene ID" value="lp_1587"/>
    </dbReference>
    <dbReference type="GeneID" id="57025173"/>
    <dbReference type="KEGG" id="lpl:lp_1587"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1337"/>
    <dbReference type="eggNOG" id="ENOG5032KX8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825717_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1364-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7907" checksum="4A4C582C711F00D3" modified="2011-10-19" version="1">MLLRHGLTSNIYLNDYLTFIQQGRDTFEFHHNLLVAQHHYHLVINAHHAFNAFYAEQKRLAEQLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP16</accession>
    <name>F9UP16_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1648"/>
    <dbReference type="EnsemblBacteria" id="CCC78955">
        <property type="protein sequence ID" value="CCC78955"/>
        <property type="gene ID" value="lp_1648"/>
    </dbReference>
    <dbReference type="GeneID" id="57025226"/>
    <dbReference type="KEGG" id="lpl:lp_1648"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1391"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="PhylomeDB" id="F9UP16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1418-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78955.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1660"/>
    <dbReference type="EnsemblBacteria" id="CCC78965">
        <property type="protein sequence ID" value="CCC78965"/>
        <property type="gene ID" value="lp_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1660"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1401"/>
    <dbReference type="eggNOG" id="COG0604">
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    <dbReference type="HOGENOM" id="CLU_026673_3_1_9"/>
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    <dbReference type="PhylomeDB" id="F9UP26"/>
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    <dbReference type="Proteomes" id="UP000000432">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="316" mass="34359" checksum="50D3386FFA4E0596" modified="2011-10-19" version="1">MKALFFNDFGDASVLQYGEVADPIVTANTVLVKTTYIGLNFADIYRRRGTYHLEKHQPYIDGYEGVGTVVAVGKQVANFKRGDRVLFVDVPFANASLVAVPADQAIKVPRAINDQQVASIGLQGMTAEFLVHDLAQNQPHDRVLIHGISGGVGQLLTQLLVANEVAVYGVASTPAKAELAYQAGATTVFMRHDPWDTTHHNFFDTVFDGVGKTLPVSLATTKHRGRVIFYGMAAGNPPVIDPVKLMSESKSLMTGDLWDYLDSAVARQCRANQLFDDVLTHRVTIRPATVYSLAEGAVAHWALETGQVAGKILLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP81</accession>
    <name>F9UP81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1723"/>
    <dbReference type="EnsemblBacteria" id="CCC79020">
        <property type="protein sequence ID" value="CCC79020"/>
        <property type="gene ID" value="lp_1723"/>
    </dbReference>
    <dbReference type="GeneID" id="57025349"/>
    <dbReference type="KEGG" id="lpl:lp_1723"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1455"/>
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    <dbReference type="OMA" id="YNGAHIH"/>
    <dbReference type="PhylomeDB" id="F9UP81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1483-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="269" mass="29647" checksum="8CA9BCDE0A932D3A" modified="2011-10-19" version="1">MERKLIALDLDGTTLNAESKLNSATIQTMQRLQAAGHIVSIITGRSYQGSQAIYDQLRLKSPMINFNGSLGHLPHQTWASEYQFTINKAIVLALVKYREQLGINEIIAENKNSTMTAGQDLIAGQFFPEIADSPRLTPDTLTRNPNSLVLLVQLDRRAAIIDWITERFGDQVDVGVWGGPNAILEITSKGVHKAKGVAYLADYFQISRRNIIAFGDEHNDLEMLAYAGLGVAMANGTDKIKATADDVTAYNNDQNGVARYLNDYFAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB2</accession>
    <name>F9UPB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889565.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1760"/>
    <dbReference type="ESTHER" id="lacpl-LP.1760">
        <property type="family name" value="5_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A46"/>
    <dbReference type="DNASU" id="1064092"/>
    <dbReference type="EnsemblBacteria" id="CCC79051">
        <property type="protein sequence ID" value="CCC79051"/>
        <property type="gene ID" value="lp_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1760"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1485"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094948_1_0_9"/>
    <dbReference type="OMA" id="PLFIWHG"/>
    <dbReference type="PhylomeDB" id="F9UPB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1515-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="92"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="28807" checksum="F1F08771ECD68A84" modified="2011-10-19" version="1">MIKVTNRHFQDVPALEVVTTTHLDQPLPLVIFYHGWQSNKELVLTQARKLARKNLRVVLPDAMNHGERHQIVSQIPSFTFWNSIQGNLGEFELIVNYYRERKLILNEQIGVGGYSMGGMTTGALLTHHPEIKAATIIMGTPNLNAYAQLVRKHAQAHAYYIPSDLALLTSWLDHYDLNLQPETINHRPLLFWHGTEDERIPYSQSRNFFDRVHTAPYAEQVAFITGYQAKHLVKVPLMNKVANFFDYYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPK2</accession>
    <name>F9UPK2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640581.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1872"/>
    <dbReference type="EnsemblBacteria" id="CCC79141">
        <property type="protein sequence ID" value="CCC79141"/>
        <property type="gene ID" value="lp_1872"/>
    </dbReference>
    <dbReference type="GeneID" id="57025468"/>
    <dbReference type="KEGG" id="lpl:lp_1872"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1578"/>
    <dbReference type="eggNOG" id="ENOG5030SMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728533_0_0_9"/>
    <dbReference type="OMA" id="LIYFPYK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1603-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="150" mass="17103" checksum="0A56FE86E5E453C3" modified="2011-10-19" version="1">MERALEALKFHFRNGDTWTVHHQDISDLWIGRVTTSYGRIKGGHMTIIHPCKSFKAEFKPDADAIDPDTTQLSSVTSGMFERVTHYQDIEKIDILFGDERGSEQIYLPFKPRDADGIDNIYQTSSLASDGKLHLVVDDERTVFDVYGDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPT6</accession>
    <name>F9UPT6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640683.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889739.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1972"/>
    <dbReference type="EnsemblBacteria" id="CCC79225">
        <property type="protein sequence ID" value="CCC79225"/>
        <property type="gene ID" value="lp_1972"/>
    </dbReference>
    <dbReference type="GeneID" id="57025550"/>
    <dbReference type="GeneID" id="66449777"/>
    <dbReference type="KEGG" id="lpl:lp_1972"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1665"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_9"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="PhylomeDB" id="F9UPT6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1689-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16082" checksum="95D60BDB5EFD38DC" modified="2011-10-19" version="1">MSLIDTLNGDLKAAMKARDKQALSVIRMLKSALMNEQINVGHDLTADEEVSVLSRELKQRRESLSEFENAGRQDLVDGVKAEIAIVEQYMPKQLSDEEVQQIVADTIQQVGATGKGDFGKVMGAVMPKLKGQADGKLINQTVKSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPZ5</accession>
    <name>F9UPZ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bifunctional protein: transport protein, MFS chorismate mutase type II</fullName>
            <ecNumber evidence="10">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_2038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889798.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2038"/>
    <dbReference type="EnsemblBacteria" id="CCC79284">
        <property type="protein sequence ID" value="CCC79284"/>
        <property type="gene ID" value="lp_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2038"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1723"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045105_0_1_9"/>
    <dbReference type="OMA" id="YIAMATF"/>
    <dbReference type="PhylomeDB" id="F9UPZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1745-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate mutase" evidence="9">
        <location>
            <begin position="383"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="53375" checksum="7E20E18B76B9A06E" modified="2011-10-19" version="1">MRQHQLSISLYLNYFIHGIGLIILTQNMQALGQHWQTPLATVSYVISGIGIGRLLAYFILGNLSDRFGRKVFVNLGMACYFTFFVGMALVTNIQLAYGLAILAGIANSALDAGTYTTFIEMGGRQGSANVLLKAFMSAGEFLLPLLVANFEAQRIWYGWSFILAAAILVVNSILLNRQQFPLKNQVSQAGTGVSQQPLKNRRWLATVGLAGYGYTSMALMILYTQWVSLFATTTLHFSSVLAHWLLSLYSIGSITGVIVIFWLLRRGVAETKLLLAMNGGSLLALAVICYSPAAGLSMLAAFGFGFTAAGGVMQVGLNLFIKGYPHMKGRITGIYFTFGSIASFTIPLVTGWLSKQNIATAMRFDLVIAVSGLAFVGLAVWALHVPTTLSQERQRINHIDQQIVRLLNQRFETVTAIGELKQQQQLPVLDQQREQRVLQQVAVKSTQTAHTPYLQAIYQAIMHNSRAYQTDLHTNLHKEDIDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ31</accession>
    <name>F9UQ31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101648.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889834.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2082"/>
    <dbReference type="EnsemblBacteria" id="CCC79320">
        <property type="protein sequence ID" value="CCC79320"/>
        <property type="gene ID" value="lp_2082"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2082"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1761"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091968_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQ31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1781-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="28591" checksum="F949335BD25B95FA" modified="2011-10-19" version="1">MTALERSWFEEAQQSMHGWDFSHLAGRWQTADLPWDYAALVREHLSADDRWLDIDTGGGELMGRFNPQPALTAVTEGWQPNIELLKQTVVKKGITLYPDAAEQLTAVPNSTFDIVTNSHGAMPVKRIAEVLKPGGRFVTQQVGATNNYALSRFFDEHYETAYPDNQLLTVMAQMQAAGFEILRAEQAYAALSFTDVGAIVYYATVIPWEFPHFDVARMLPKLHQLQSLLAINGRVTTFEDRFMIIARKLARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ60</accession>
    <name>F9UQ60_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S_biosyn domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889863.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2113"/>
    <dbReference type="EnsemblBacteria" id="CCC79349">
        <property type="protein sequence ID" value="CCC79349"/>
        <property type="gene ID" value="lp_2113"/>
    </dbReference>
    <dbReference type="GeneID" id="57025655"/>
    <dbReference type="KEGG" id="lpl:lp_2113"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1790"/>
    <dbReference type="eggNOG" id="ENOG50341CT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141575_1_1_9"/>
    <dbReference type="OMA" id="KKGGTCT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1810-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="14558" checksum="0944466750CD3B86" modified="2011-10-19" version="1">MKINIKDDAQAYLADKIPAGSQVILTTDDGSNKYSSLGGSCAIGNKFQLVILKAADPDYTTPLENNAGYVMHVAPADEAYLGNGLNISRWHNALALKDDSGMLDGALAVVDWRDVSPETEAERREKMQTIGTKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ67</accession>
    <name>F9UQ67_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">lp_2122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640800.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889870.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2122"/>
    <dbReference type="EnsemblBacteria" id="CCC79356">
        <property type="protein sequence ID" value="CCC79356"/>
        <property type="gene ID" value="lp_2122"/>
    </dbReference>
    <dbReference type="GeneID" id="57025662"/>
    <dbReference type="KEGG" id="lpl:lp_2122"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1797"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_9"/>
    <dbReference type="OMA" id="FKMDQFP"/>
    <dbReference type="PhylomeDB" id="F9UQ67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1817-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="574" mass="63903" checksum="3D1CFE087ED913FB" modified="2011-10-19" version="1">MSSEIQITPFGGVRENGKNMYAVEVDGDIYILDCGLKYPENELLGIDIVIPDFSYLRENADRIVGVFLTHGHADAIGALPYFLNEFNVPVFGSELTIELAKIQLQKDPKAKNFNDFHIINEKTEIDFGTVTVSFFRTTHSIPDSMGIVLQTSAGEVVYTGDFKFDPTAAGDYQTDFARLAEIGSKGVLALLSDSANAENYEQPVSEREIAAYVLETFKYHPGRIIVASVASNILRIQQVLDAAAKSNRKVALMPGDVESIVKTAIDLGKLHMPEDVVVPLKAIDKLKPEQIVILQTGRMGEPIKALQRMANKQESKVNIEKGDLVFITTTPSHSMETVVAKTRDMIYRADADVKAIADEMNSSGHAAKRDLQMMINMMKPQYFIPIQGEYRLLDAHADFAREVGIPDDHVLIAAKGDQLRYDGDTMHLAGSIEVGDTMIDGIGVGDIGNIVLRDRKILSEDGIFVAVVTIDRKKKKIIATPKITSRGFVYVKTSKDLMQESAELVKTTVQENLDNKEFDWGHLKQAVREKLNHYLWDQTKRHPVILPVIMEVNQHHRRTKKAKPAKPVETESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ90</accession>
    <name>F9UQ90_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 15">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pdhD</name>
        <name evidence="18" type="ordered locus">lp_2151</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13 15">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="15">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 15"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640822.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2151"/>
    <dbReference type="EnsemblBacteria" id="CCC79379">
        <property type="protein sequence ID" value="CCC79379"/>
        <property type="gene ID" value="lp_2151"/>
    </dbReference>
    <dbReference type="GeneID" id="57025685"/>
    <dbReference type="KEGG" id="lpl:lp_2151"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1820"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_9"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="PhylomeDB" id="F9UQ90"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1840-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="17">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="16">
        <location>
            <begin position="351"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCC79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="470" mass="49944" checksum="10293EF86418CFFD" modified="2011-10-19" version="1">MVVGDFAEERDTMIIGAGPGGYVAAIRAAELGQKVTVVEKEYIGGVCLNVGCIPSKALISAGHRLQEAKDSKIFGIKNIQDPVLDFKVTQDWKDHQVVDRLTGGVEMLLKKHKVEVVRGEAYMHDNHTLRVMNGDHTGQTYKFKHLIIATGSRPVEIPGFKFSGRVVDSTGGLNLPEVPKELVVIGGGYIGSELAGAYANLGAHVTILEGTPQILPNFEKDMVKLVLNSFKKKGVDVITNAMAKNSEQDDSGVTVTYAVDGKETEIHADYVMVTVGRRPNTDDMGLEYTDVKLTKRGLIEVDEQGRTAAEDIFAIGDIVAGAALAHKAFAEAKVAAGAISGKKTANDYVSIPAVCFTDPELATVGMTKAEAEEAGLQVKTSKFPFAGNGRAISLNAMDGFFRLVSTKDEGTIVGAQIAGPGASDLISELSVAVNGGMNVEDLALTIHPHPTLGEVVQEAADEAMGYPTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ95</accession>
    <name>F9UQ95_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640826.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889898.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2156"/>
    <dbReference type="EnsemblBacteria" id="CCC79384">
        <property type="protein sequence ID" value="CCC79384"/>
        <property type="gene ID" value="lp_2156"/>
    </dbReference>
    <dbReference type="GeneID" id="57025690"/>
    <dbReference type="KEGG" id="lpl:lp_2156"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1825"/>
    <dbReference type="eggNOG" id="ENOG502ZQCN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140961_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1845-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="18690" checksum="757DF1F9813AF670" modified="2011-10-19" version="1">MQSWLTIIGGVLMAIVVYELLRRQVLKRAALKIRRAGQRTVDSAMVAAFKVLANAMTIQEVAGAIHSVPVADVWGRGVMAFEYVLDAPGMVTADLPEVRRLFNNELQAYAIHNQVVAFREAGPALRVTDAWLRSGQLHLDIAYLMNEATLEYLEDLRRLNSSAPKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC9</accession>
    <name>F9UQC9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transpeptidase, penicillin binding protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pbp2B</name>
        <name evidence="7" type="ordered locus">lp_2200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101681.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2200"/>
    <dbReference type="EnsemblBacteria" id="CCC79418">
        <property type="protein sequence ID" value="CCC79418"/>
        <property type="gene ID" value="lp_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2200"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1859"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_1_9"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="PhylomeDB" id="F9UQC9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1879-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="6">
        <location>
            <begin position="597"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="6">
        <location>
            <begin position="658"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="713" mass="77233" checksum="B7E14E2536510D34" modified="2011-10-19" version="1">MNKNKQRMTSKRSPKQNRRIFGQWLFFGAIAVFGVLIIRFSYIAIVRHVNGVNLVEATKKLYTEDQTITAKRGTIYTANGDPIAEDTSTYTVYAIMAKNQQSASGKALYVKNNAKAARVLSKYLPISYKKALATLQKGAGKFQIEFGTAGKNISLTTKEKIDAQNVAGLHFIESEARLYPNGTFASHLVGLTTSKSQKDTDQTRLTGSMGIELAFNKQLSGTDGRKTITKSGYQGSTETGKKVKDGDNIYTTIDSKLQTLLETKVSQVNAKVSPKSMTATLMNAKTGAILATTQRPTFNAQTKTGLSKMWRNLLVEDTYEPGSTMKVFTMAAAIDSGKYNANVTVPTGEYKIGNNTVPDWNTSGWGNITYAKGFALSSNTAMAHLEQAMGAKAWLKYIKRFGLRESTNSGLDNEQSGSIQFTYPIEQADTAFGQGIQVTAMQMLRGFTAIANHGKMLQPYFISKITNPNTNKTVYTGKKKVVSQPISSKTASKVLDHMQDVVYKSYGTGSSYKISGYRIAAKTGTAQVSNGSTYEQGDNTYLYSVVGMAPAKNPKYIMYITMKQPTLNGSSASDDMAEIFDTVMKRALEEQKASETKATTIKMKDLTSKSTSAAKKAAKKQGLDVVVVGKGSRVVKQSISSGTVVSSGQRVILVTNGQMYMPNLSGWSASEVADFATLTGVKLTTSGTGYVKTQSVTAGNPIEAKQAISVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF9</accession>
    <name>F9UQF9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1461 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889962.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2234"/>
    <dbReference type="EnsemblBacteria" id="CCC79448">
        <property type="protein sequence ID" value="CCC79448"/>
        <property type="gene ID" value="lp_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2234"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1890"/>
    <dbReference type="eggNOG" id="COG4478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093826_1_1_9"/>
    <dbReference type="OMA" id="WPLLFIF"/>
    <dbReference type="PhylomeDB" id="F9UQF9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1933-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07314">
        <property type="entry name" value="DUF1461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01906">
        <property type="entry name" value="integ_TIGR01906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="25139" checksum="BE429019C283FC84" modified="2011-10-19" version="1">MVWLNKFKNAAQWLSLYLWLVSGTIIVTINASWLYFANAVGQKLGATVNLTLGRLMTNYYQLLAYLNFPWVPKLTMNDFTDSTSALVHFSDVKNLFMLDYGVFIVTSVVVYFFWQRLRRDRQLWRLVLPMQTALWVPPVVTVIMAINFDQFFIMFHKILFRNSDWLFDPLLDRIILVLPDTFFGQCFVLVFILIEWSFFYLLSIGRQALREAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL0</accession>
    <name>F9UQL0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphatase (MPP) superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890013.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2299"/>
    <dbReference type="EnsemblBacteria" id="CCC79499">
        <property type="protein sequence ID" value="CCC79499"/>
        <property type="gene ID" value="lp_2299"/>
    </dbReference>
    <dbReference type="GeneID" id="57025835"/>
    <dbReference type="KEGG" id="lpl:lp_2299"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1943"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_9"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="PhylomeDB" id="F9UQL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1983-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="268" mass="29640" checksum="FA5C09440887B55D" modified="2011-10-19" version="1">MRILFVGDVMGNVGQTAVTTYLPKLKRRYKPQVTIVNGENATRGRGINQEVYKDILTAGADVITMGNHTWDNNEIFDFINGAKKLIRPLNFPPATTPGVGYTIVKVNTVKLAVINLQGNVFMGQNLADPFTTVQPLVEQLREETPNIFIDFHAETTSEKEAMAWYLDGQVSAVVGTHTHVQTSDERVLPNGTAFLSDVGFTGPYNGILGMTRENVIQRFLEQMPTRFNVQEDSPAVLSGCVIDVDGQSGRAKKIARILINPDHPYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL6</accession>
    <name>F9UQL6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-dependent proteinase, M16 family</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644640.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890019.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2305"/>
    <dbReference type="MEROPS" id="M16.A20"/>
    <dbReference type="EnsemblBacteria" id="CCC79505">
        <property type="protein sequence ID" value="CCC79505"/>
        <property type="gene ID" value="lp_2305"/>
    </dbReference>
    <dbReference type="GeneID" id="57025841"/>
    <dbReference type="KEGG" id="lpl:lp_2305"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1949"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052317_0_0_9"/>
    <dbReference type="OMA" id="FFEHLLF"/>
    <dbReference type="PhylomeDB" id="F9UQL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1989-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
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        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="50"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="181"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="433" mass="48555" checksum="257E09A4C3B1D6E5" modified="2011-10-19" version="1">MKVKKYDQFNESCYQAQLDNGLTVTLLPKAGYHKTYATFTTNYGSIDNTFVPAGSTEMQRFPDGIAHFLEHKMFEKADHDAFQIFGQYGASANAFTSFTKTSYLFSATRHLQDNLMTLLDFVQDPYFTPATVDKEKGIIGQEIEMYDDDPSWRLYFGMIGNLYPNHPLQYDIAGTTESIAKITADDLYAAYRTFYHPENMTLFVVGNFDPDEVLGWITTNQATKKFAAFQPIERKIPETATDGHDIIPYRTIDMPVNRAKSIVGVKGLLPIEAGAAALKYRAAVNVLLELLFGDTSADYLRLYDQGIIDDTFGYDFELQSGFNFVTFSGETDDPAQFDAAIIDVLENWRTAVVGQEAALALVKKEMIGRVVFMANSLEAIANRYDQRLFGTATIFDEPGIIDQLTLADLQTVAEQLLTSQAISEYQIRPQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP5</accession>
    <name>F9UQP5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase, class A</fullName>
            <ecNumber evidence="4">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bla2</name>
        <name evidence="4" type="ordered locus">lp_2341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101719.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2341"/>
    <dbReference type="EnsemblBacteria" id="CCC79534">
        <property type="protein sequence ID" value="CCC79534"/>
        <property type="gene ID" value="lp_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2341"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1979"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_9_4_9"/>
    <dbReference type="PhylomeDB" id="F9UQP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2018-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="3">
        <location>
            <begin position="150"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="376" mass="40646" checksum="152A5A756A26729B" modified="2011-10-19" version="1">MSCQNCGYQNSPHAVTCLKCGHRLTPVNGDVNQQSRVQRRRQQSRRTTFSSRFRPQTLLGVLIAGLLLLGGGYIAGQLLWSSTTSATAESAGKSQVHKPAASDSDAPMKATPTFPTTTVTDLVAQATNGLAGQTSVAVMPLTGSQTVVLNNRSQRAGSLITLFIMVTAFDQVHQNNWRMQDRYTLRAADKVGGTGTLHTLPAGSQLTYAEITKRMITESDNTAANIMLDRVGGFSAVNTEIAQLGLTDTKMARRLMDTAALKAGHDNDTSVRDVATVLKRLANLRLISNKADHAMLTILKANTDHSKLVKNLPTRATIYNKTGDYQAYGVQNDAAIVQNRQGTFIMTMMTASGERTAQTVAMNDLGQALYRAILEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW2</accession>
    <name>F9UQW2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 35 terminase large subunit TerL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2422"/>
    <dbReference type="EnsemblBacteria" id="CCC79601">
        <property type="protein sequence ID" value="CCC79601"/>
        <property type="gene ID" value="lp_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2422"/>
    <dbReference type="eggNOG" id="COG1783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1242489_0_0_9"/>
    <dbReference type="OMA" id="TINWETY"/>
    <dbReference type="PhylomeDB" id="F9UQW2"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035412">
        <property type="entry name" value="Terminase_L_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04466">
        <property type="entry name" value="Terminase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_3" evidence="1">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="26181" checksum="300BA03918BFED04" modified="2011-10-19" version="1">MSTTQQFNLSLRQLIGSGYTDFWRDHHFYRVIKGSRGSKKSVTTAHNLIYRLVKYHWSNILVVRRNANTNKTSTFVECKNAINDFHLERYFKYNESLPEITYLPTGQKIIFRGLDDPLKLTSVNVLTGELCWLWVEEAYEIESFSKLQTVIESLRGNDPQVFYQVTLTFNPWNEHHWLKREFFDQKRDDAFVRTTTVRCNEFVSDEYKQRLYRFIPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY3</accession>
    <name>F9UQY3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101774.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2444"/>
    <dbReference type="EnsemblBacteria" id="CCC79622">
        <property type="protein sequence ID" value="CCC79622"/>
        <property type="gene ID" value="lp_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2444"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2066"/>
    <dbReference type="eggNOG" id="ENOG502ZYP1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132040_0_0_9"/>
    <dbReference type="OMA" id="RYPREYA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2109-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19522" checksum="2D6A909189DABAD7" modified="2011-10-19" version="1">MKNKFTEQLSLALGRDKAQTQQQIADRTHVSPGQLSRLKSGSRSTDSQIRKSLANVINDFWLSYSGARENFGVLSFQNDRQLQGDMFSALMKQKKEQRQRERIEAEFEEAITVKPRDRTPAQQLVIERYPREYAEEISAEITDLAKKAEYAGIPMDKLQEVIDKVNQENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY9</accession>
    <name>F9UQY9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 7 extracellular protein with lipoprotein anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101780.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2450"/>
    <dbReference type="EnsemblBacteria" id="CCC79628">
        <property type="protein sequence ID" value="CCC79628"/>
        <property type="gene ID" value="lp_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2450"/>
    <dbReference type="eggNOG" id="ENOG5032Z4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164000_0_0_9"/>
    <dbReference type="OMA" id="GSWIITF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2115-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388104" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="111" mass="12020" checksum="0F537E2F28BB1EFD" modified="2011-10-19" version="1">MKKMSIGFIAVIAIIFTLTGCGNKKPDYTASTAESALNTNKDIEGKTVQFKISKVVPNSAFGYNLETGKHLNFVSSENPKVNKGETVTVRVKKASSSVGSWVISYTNLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ5</accession>
    <name>F9UQZ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2b protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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    <dbReference type="KEGG" id="lpl:lp_2483"/>
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    <dbReference type="OMA" id="ERRVRYN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2146-MON"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="393" mass="44713" checksum="71A39852B0E06027" modified="2011-10-19" version="1">MTTDYRLTSDADREAFYQLYQYAFNNHDTPARRRFFMDRYQHGWIYGRHDHGQLVSGLYSLPLAVNFHGVTYRMNGIGDVMSAPEYAGQGGAGQLLTTALTEMAANHVTLSYLAPFAYGYYRRFGYEHVFNHAHQVMAAPDLPRVKPTDWSGTITRYGNDGLAQINDFYARQPQNQCGGLIRPAWWQHYLTLKHHWSVAIYRNAAANIEGYLIYERQATNFAIQEWVTSTPTAFERLANFITKHGTTFETFSYDSPSATNGLDLLADPYRLKVTVQPYMMARIVDLYDFIKRYPFLTDIQPIRLAVSDATLPANQGIWSLTRHNGQVTLNRVSDQLTGPADIQLTIQQLTTACFGTQSLARAYQHGLITGDVNAINRLDTSLVKERPALIDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR2</accession>
    <name>F9URR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890415.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2796"/>
    <dbReference type="EnsemblBacteria" id="CCC79901">
        <property type="protein sequence ID" value="CCC79901"/>
        <property type="gene ID" value="lp_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2796"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2341"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012726_0_0_9"/>
    <dbReference type="OMA" id="HANTATF"/>
    <dbReference type="PhylomeDB" id="F9URR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2392-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07523">
        <property type="entry name" value="Big_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="3">
        <location>
            <begin position="571"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="3">
        <location>
            <begin position="671"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="3">
        <location>
            <begin position="744"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112306" checksum="E54491E8F7C3BC88" modified="2011-10-19" version="1">MRLIVRSVRLFLKKWGITINYRESEVKCYKMYKSGKMWLLASASLLLLNTQLLTAHADEPTSASTSETSVVATNGVSIQNQGSSNQTLASSVSKTDNVVVANDENASITNQTVIDAQPATNDEPQSAASTAALNGTSGAPNSEVAADSMAAVNGLNTVAPATNSYEASRTDDLFSNAAESTVSEQQPEASEQLLLDTADASERKPAADLQHVEQHQLVDDLKVESQHVDTRAVTRADEDEMSGNFGVDWHFDASTGTLTLNGGTLNNSYGDNPWRRKSWAPMIKCIVIADKIVAGTNMNSLFANLDSVTRYEGLEKIDTSAVTNMQSLFKENTSLERLDLSAWQVGNVTTMVNMFMGNFMGTELKYLNLSGWDTHNVANMQNMFQFNGQLRTIDGLTDWDTRSVTTMANMFARTGVRHLNLTSFDSASLVEIDGAFAQMSDLERIEFGTQFTVAKVTQINSLFNDDAKLKVLDLSHFNMQNIEQNWQMLAGLTSLQTLTLGPGLDFSQHGTQPLVDLPEVPKNSKYTGKWVNVADSSQTFTSAELLAQYSGNHANTATFVWETVSAAVITGKDSTLFLNQKWDWTQNIAQLVDQNGQLVDPGVLFNTDPQAVTVSGEPVDTSQPGSYHVILTYAGRQTTVVVTVVANQSQLNLHAQEVAVEIDLATGSAVWRPRDNFASATDADGRSVEWQNVTVLGEPDLTRPGTYEVVYQFTDLTGQLVTATTTVTVTEQEADVEDLTELVVQDTTVTVGDHWQAADNFVSASDATGRLLTLADLVVIGDVDTTQPGTYEITYQYTNANGLQWTQTATITVVEGAGNGETPLPGEPAEPELPEEPGTPEQPETPETPETPETPETPETPETPETPETPETPETPETPETPETPGEPSAPGTPDQPELPEVPEQSEQPGTTEHPDTSDPNSGLTGANAGSSSQREQADTIVRPEFNGGLEKQVTTVFRDNLKLNTAERNEDGIDAKRYAKADTAKPEVTMAPVSHPASVAGELPQTSEQVNRFGLLGLMMLMVTGLASIVGIKRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW7</accession>
    <name>F9URW7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644834.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890470.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2866"/>
    <dbReference type="EnsemblBacteria" id="CCC79956">
        <property type="protein sequence ID" value="CCC79956"/>
        <property type="gene ID" value="lp_2866"/>
    </dbReference>
    <dbReference type="GeneID" id="66450496"/>
    <dbReference type="KEGG" id="lpl:lp_2866"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2399"/>
    <dbReference type="eggNOG" id="ENOG5030A7U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2523378_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2453-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9577" checksum="AFD371BBD686A4CC" modified="2011-10-19" version="1">MQLLILGVIAIVIFILEEYLFTASRYFWVGGIVPVLWTVFLAYLVVVNAMNLTVREYALAIIAVIIPYVCWGNGYQRHQRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX0</accession>
    <name>F9URX0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79959">
        <property type="protein sequence ID" value="CCC79959"/>
        <property type="gene ID" value="lp_2870"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2870"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2402"/>
    <dbReference type="eggNOG" id="ENOG502ZPGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142052_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2456-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="134" mass="15616" checksum="A36F81A71AA0C41D" modified="2011-10-19" version="1">MLDVSKESVVRMTDKEIIIQLYRDENIAMVQKNLSRLNEILAPTMKLTHMTGYVQSKLEWIDQIQNEEMQYFASKEDTIKAIQIEGNRASLIGQNQVQARIWGGGTHTWRLQMQMFYEKKNGDWVISAQKASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX1</accession>
    <name>F9URX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101944.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890474.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2871"/>
    <dbReference type="EnsemblBacteria" id="CCC79960">
        <property type="protein sequence ID" value="CCC79960"/>
        <property type="gene ID" value="lp_2871"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2871"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2403"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="PhylomeDB" id="F9URX1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2457-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="33686" checksum="41EBC88BA497C024" modified="2011-10-19" version="1">MFQQMQYFIAIVNNHSFTQAAVDCHISQSAISQQMKELESQLGVKLLNRKGRSFEVTEAGQYFYIHSQDILADVDQLIKKTIKIEKNDEVELRVGYLRSFGTAEFLQTVSKFTQEFPKVKIKISSGTHEELYELLQTGKIDLNFSDQRRALSNEYQNEFLTASEFMVAVNNSLPVETQKIDVADLVDIPCILIIDGHQQVSEEEYYRNVLGVKSEFVIAKSYDEAQMLIASNQGYLIINQRMRTQLDKDIVKMISLVKGDRKLIQNYYAYWQANNSGYYIETFAELLKQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9US11</accession>
    <name>F9US11_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101975.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2924"/>
    <dbReference type="EnsemblBacteria" id="CCC80000">
        <property type="protein sequence ID" value="CCC80000"/>
        <property type="gene ID" value="lp_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2924"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2442"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_2_9"/>
    <dbReference type="OMA" id="VEYTESH"/>
    <dbReference type="PhylomeDB" id="F9US11"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2496-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="239" mass="27260" checksum="A7D21617EFFB8FB1" modified="2011-10-19" version="1">MGKQTFSDIYHVLKDRILTGHYSVKMRLPIEDELITEFDSSRYAVRKAIAQLAKDGLVYSVKGRGVVLLEHTPQTQQFNLALNNLNGLQSLNAERHLDYQTEVVAFQQRIVDQPLSTHTAFEVGIPVYAIQRVRIVDGIRAVLDINYFNAQRTPTLTKTIAQHSIYQHFKKNGLKIAVVKRMLRVESANELDKAQLALGDNNCVGNMISIAFNDEGRQVEYTESHFIPNEFNFNELIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB4</accession>
    <name>F9USB4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter,ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livD</name>
        <name evidence="5" type="ordered locus">lp_2982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="EnsemblBacteria" id="CCC80044">
        <property type="protein sequence ID" value="CCC80044"/>
        <property type="gene ID" value="lp_2982"/>
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    <dbReference type="eggNOG" id="COG0411">
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="176"/>
            <end position="248"/>
        </location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="29569" checksum="34392DC03F8519AE" modified="2011-10-19" version="1">MGTELQFVQYLHQMRDYNDQHPTTKGLILLGYLERDFIRFYRAGKIEEGIQFAKKNLTRSRDLLNKLSSEEKQLQLSALVDVLAFEGIQNHAEIYEFVKLRNDYHRWLVKLPVTTERYQPLVVQIIRDFAAIAKPNALAYNAHLESTLDVMYYTNAHLHDQLSVKKVLAHVNARCNPESVRRSFSQEMHMSIRDYINAKKIQEAEHMLLATDLTIRAIAAELCFYDAADFSKRFKKETGQTPLEFRQLNTRTD</sequence>
</entry>
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    <accession>F9USJ2</accession>
    <name>F9USJ2_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Cell surface protein, CscC family</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3075</name>
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    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80122.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <location>
            <begin position="709"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="124"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80122.1"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="915" mass="98519" checksum="90CE0711CCF9568F" modified="2011-10-19" version="1">MQHRQLWYRGGLGLALALVVVGYRGSRTVIRAVPRAQLSVDQKMPSTSSVFSASKLTLQDEANNSAPQVSPEAQESSGPDKQSDLTSGSSTSSSGISSGNSSGSTILENAKNNQTSETATTKAAEMVNGTVKMTLDTNGTLHLSGGSFGASLGSATGSWIVKTLTANGYQPTQVSKIVIDGKITATTMTNYSYLFANLPNVTAIDGLANLNLTGVTDISWLFLNCSQLGALDLNSWDVSSVIRMEGTFQNCAKLVTLNVANWNTDSLQYLIDTFNGDSSLTSLPVGKWNTSKVATMMRTFTDCSSLTSLDIANWDTRVVTNMSAIFRGMSKVKSLPIDKWQTGRVVNMQLVFSGDTSLESINVANWDTSRATALDGTFAKLPNIKSLPLDNWNTSNVQTIRSTFYGDTNLTQLPIDNWNVGKVFDFNSTFSGCASLTTAPVANWNTQSATNLGYTFEGMTSLTSLPVDNWQTGTVTNMAGTFSGVSQLKSLPISKWNTKNVQNMAGTFSKMSSVTALPVDNWQTGNVTTMRGIFTKVSQVKNLPVGKWNTAKVVDMGQVFYGNPQLTSLPIENWNTSSATDFSQLFAEDSGLQTLSLGAWNTTKVTNFESVFQNTSLDKLDLTGWNTNSAQTYTNAFSSKLPPKRLLLGPSFNFFKSESWHLPNPSSEAPYIGKWRSLNNKKVYTSADLMTKYDGKTIVGEFEWATGNTITVKYVDAAGKYLAPDTKISGATGDAYHIKPIEIQGYVPDQPDGVQGNFTDKDETITLMYNPGGLMFVSAPQTINFGQNPITGKSENYGASYDTGLVIQDGRSIGSTWSLNATLSASGFTSKQSARPLAAVLSYKDQQTGGGSILTPGVARLIVNNHQTVSNQGVNILGQKTALGALSLQVPTDRALTDTYQATVTWTLNQGVPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9USK8</accession>
    <name>F9USK8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3094"/>
    <dbReference type="EnsemblBacteria" id="CCC80138">
        <property type="protein sequence ID" value="CCC80138"/>
        <property type="gene ID" value="lp_3094"/>
    </dbReference>
    <dbReference type="GeneID" id="57026404"/>
    <dbReference type="KEGG" id="lpl:lp_3094"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2584"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157172_0_0_9"/>
    <dbReference type="OMA" id="GAYTIFP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2631-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="94" mass="10145" checksum="A66417E6FBA7475A" modified="2011-10-19" version="1">MKTYQFDAPIQAATIGKGGAYVACPFDIRDLFGKGRVKVHATFDEVPYNGSIVNMGVKNLDGSICYILGIRKDIRAKLHKSIGDVVAVTVTAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL9</accession>
    <name>F9USL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelatin ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fhuB</name>
        <name evidence="8" type="ordered locus">lp_3105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890663.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3105"/>
    <dbReference type="EnsemblBacteria" id="CCC80149">
        <property type="protein sequence ID" value="CCC80149"/>
        <property type="gene ID" value="lp_3105"/>
    </dbReference>
    <dbReference type="GeneID" id="57026415"/>
    <dbReference type="KEGG" id="lpl:lp_3105"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2595"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_9"/>
    <dbReference type="OMA" id="ICGAIMQ"/>
    <dbReference type="PhylomeDB" id="F9USL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2642-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="332" mass="34960" checksum="867865D117B0A1B7" modified="2011-10-19" version="1">MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRVPRVLGAALIGAALAGSGALMQAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTTGWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSLLTALSEGLALVLQLKQDLAFWYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLALICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARLVNPPHETPFGIIISLIGVPCFIYLARKEPMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ7</accession>
    <name>F9USQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall hydrolase/muramidase, middle</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acm3-M</name>
        <name evidence="2" type="ordered locus">lp_3153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3153"/>
    <dbReference type="EnsemblBacteria" id="CCC80187">
        <property type="protein sequence ID" value="CCC80187"/>
        <property type="gene ID" value="lp_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3153"/>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738233_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9USQ7"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
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    </dbReference>
    <dbReference type="Pfam" id="PF08460">
        <property type="entry name" value="SH3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="150" mass="16758" checksum="81688FEE88D0DD65" modified="2011-10-19" version="1">MPTTEYLNGEDVTIEATFRKYPDWATSIVDHGAFLNQNSRYRNLLGVKNYSTVAWDLQNDGYATAPNYATSLINAIQDYDLQEWDQEAFTGNTGSTTTTTGNHRSGTYTFIQNSNIQTEPSLSAPIIGVYYPGDVVNYTGQIKAEGYTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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    <name>F9USU2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0119</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100891.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888187.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77673">
        <property type="protein sequence ID" value="CCC77673"/>
        <property type="gene ID" value="lp_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0119"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.97"/>
    <dbReference type="eggNOG" id="COG1051">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_0_9"/>
    <dbReference type="OMA" id="GEQPAAC"/>
    <dbReference type="PhylomeDB" id="F9USU2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-95-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17366" checksum="4F2AB1A5BAC78432" modified="2011-10-19" version="1">MANYIKEIRALVGHKPIILNTAAGILVNDQQQVLLNLRTDTHNWSLPGGYLEYGETYATTCLREYKEDSGIDVEVVDRIGIFDKGETAYPNGDVAQTISALFLVKPIGGHVLTQATDETLKLDYFDFDNLPPLLNQQNADMIHAAQEYLQTHSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV6</accession>
    <name>F9USV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641738.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888201.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0134"/>
    <dbReference type="EnsemblBacteria" id="CCC77687">
        <property type="protein sequence ID" value="CCC77687"/>
        <property type="gene ID" value="lp_0134"/>
    </dbReference>
    <dbReference type="GeneID" id="57026974"/>
    <dbReference type="KEGG" id="lpl:lp_0134"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.111"/>
    <dbReference type="eggNOG" id="COG2807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038046_1_0_9"/>
    <dbReference type="OMA" id="RDPLAWQ"/>
    <dbReference type="PhylomeDB" id="F9USV6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-109-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="7"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="41987" checksum="CB92161B2FFFD330" modified="2011-10-19" version="1">MTTTHQHSRYLTLGMMLAATNMRLPITMMPGLISSLKRTLGLPSSMAGLLTTIPLLTFAIMSPLIAHWGRRFGNELTIYVMLIFLAVGSYLRVIPTIAALFIGTLLVGIGADGGNVLIPAIIKDNFPTKIPVATSQYTLSMLLVGSLGTGLSGVLAAHWSLPLTMAVLSVIGLINLVVWLPNLKYNHRAPTVAMTASDGQSTATHGSVWRRPLAWVVTAFFGLQALVYYSLLTWLPTVFVAHGFSLIVAGNLVTVMQLSGLPMSYLVPATSGHRRGVWAMIMVVGVGFIAGIGGILLSGTNFWVAALSCVLLGLGSGAAFSLAVVFFTQKTTNGFETADLSGMAQSAGYLLAAVGPVLFGWLGGQLGWGPVLWLAIILSALLALSGSIIFQHATIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ7</accession>
    <name>F9USZ7_LACPL</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts1BCA</name>
        <name evidence="16" type="ordered locus">lp_0185</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641781.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888242.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0185"/>
    <dbReference type="TCDB" id="4.A.1.2.19">
        <property type="family name" value="the pts glucose-glucoside (glc) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77728">
        <property type="protein sequence ID" value="CCC77728"/>
        <property type="gene ID" value="lp_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0185"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.153"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_1_9"/>
    <dbReference type="OMA" id="MANIGQG"/>
    <dbReference type="PhylomeDB" id="F9USZ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-150-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010973">
        <property type="entry name" value="PTS_IIBC_sucr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01996">
        <property type="entry name" value="PTS-II-BC-sucr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="121"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="510"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC77728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="651" mass="68515" checksum="CBFB535EDDB73DD6" modified="2011-10-19" version="1">MNHQEVADRVLNAIGKNNIQAAAHCATRLRLVIKDESKIDQQALDDDADVKGTFETNGQYQIIIGPGDVDKVYDALIAKTGLKEATPDDIKAVAAAGQKKNPLMDFLKVLSDIFIPIVPALVAGGLLMALNNVLTAEHLFMAKSVVEVYPGLKGIAEMINAMASAPFTFLPILLGFSATKRFGGNPYLGATMGMIMVLPSLVNGYSVATTMAAGKMVYWNVFGLHVAQAGYQGQVLPVLAVAYILATLEKFFHKHIKGAFDFTFTPMFAIVITGFLTFTIVGPVLRTVSDALTNGLVGLYNTTGWIGMGIFGLLYSAIVITGLHQTFPAIETQLLANVAKTGGSFIFPVASMANIGQGAATLAIFFATKSQKQKALTSSAGVSALLGITEPAIFGVNLKMKFPFVFAAIASGIASAFLGLFHVLSVAMGPASVIGFISIASKSIPAFMLSAVISFVVAFIPTFIYAKRTLGDDRDQVKSPAPTSTVINVNDEIISAPVTGTSESLKQVNDQVFSAEIMGKGAAIVPSADQVVAPADGVITVTYDSHHAYGIKTTAGAEILIHLGLDTVNLNGEHFTTNVQKGDTVHQGDLLGTFDVAALKAANYDPTVMLVVTNTANYANVERLKVTNVQAGEQLVALTEPTASSVAATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT13</accession>
    <name>F9UT13_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, aldo/keto reductase family</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100917.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0206"/>
    <dbReference type="EnsemblBacteria" id="CCC77744">
        <property type="protein sequence ID" value="CCC77744"/>
        <property type="gene ID" value="lp_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0206"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.170"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_9"/>
    <dbReference type="OMA" id="MYTAHPD"/>
    <dbReference type="PhylomeDB" id="F9UT13"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-166-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="29345" checksum="85721B2375DDF114" modified="2011-10-19" version="1">MTYSAASTRYDELPIRRVGKTGLQLPVVSLGLWRNFGDEAPFANSRKVVLDAFDHGVFSFDLANNYGPSKGSAERTFGQIMQRDLKPYRDELVITTKAGYPAWSGPYGAFGSRKTLISSLDRSLKQMHLDYVDIFYSHRPDPNIDLYETAAALDQLVRLAEGLLTQRYLQGIPADFPIHRTNKYLFDQGTAAVVNQLNALNRIAEQRGQTLAQMALAWLLRSQVVTSVIIGTTNVDHLHANLEATHNLTFSDDEVKAITAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC3</accession>
    <name>F9UTC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, sucrose-specific EIIBCA component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts26BCA</name>
        <name evidence="16" type="ordered locus">lp_3219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890755.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3219"/>
    <dbReference type="EnsemblBacteria" id="CCC80241">
        <property type="protein sequence ID" value="CCC80241"/>
        <property type="gene ID" value="lp_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3219"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2689"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_1_9"/>
    <dbReference type="OMA" id="RIESEPN"/>
    <dbReference type="PhylomeDB" id="F9UTC3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2729-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010973">
        <property type="entry name" value="PTS_IIBC_sucr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01996">
        <property type="entry name" value="PTS-II-BC-sucr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="123"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="498"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="641" mass="68349" checksum="9FEBF6EF96E228C8" modified="2011-10-19" version="1">MSKNYQVLAKKIIDIVGVDNVESVTHCQTRLRFVVKDPKQIDKAALEDLDEVKGVFFGSGQYQVIIGTGVVNDVYDAIEKLHLVNAIYSQETTTTPTPDNQKSPLQRFMAMLSGIFIPIIPVIAATGLFLGLQSALTNNQVLQLFGTSSAAIPASLNTVISVLTGTVFSFLPALIVWSTFRYFKGTPIVGIVIGLMLVSPSLPNAYSVAGGTAKAIMLFDRIPVIGSQGSVLTALVAGFLGSKLEHYFHKHVPNVLDQILTPFLTMLVTFGIMILGVGPVVHWIENVMISGVEGLINLPFGIGGFLIGAAYPLMVLVGIHQMMIAIETSLLAATKLNPLITLEAMYGFANLGVALAMILRAKSQKAKANFIGAFSSQLFGVSEPTLFGVLIRYNFKPLVVTVLTSGIGAGVLSVMSVAANSYGLAVVPSYLMYIYNVRDLLIYTVVSLLTVAVAFIATNMFAIPKDILKSDQVQPKIVDDTIFSPVSGKSIALSTVNDPVFASKMMGDGIAIKPQEQGPVKVYAPQSGQMSVVADTGHAYGLTTNNGVELLIHIGIDTVSLKGQGFKVIVKPGQTVQKGDLLGEFDSTVLKAANLDDTVMVIVTNSKNYQRIESEPNQSIQSGAALLAIQGRPEMTTATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC5</accession>
    <name>F9UTC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family,sucrose-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890757.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3221"/>
    <dbReference type="EnsemblBacteria" id="CCC80243">
        <property type="protein sequence ID" value="CCC80243"/>
        <property type="gene ID" value="lp_3221"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3221"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2691"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="OMA" id="DGLIFCS"/>
    <dbReference type="PhylomeDB" id="F9UTC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2731-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="36742" checksum="E0B41455001D7D31" modified="2011-10-19" version="1">MTTISEIAAEAGVGVGTVSRYLNHRPSVSVAKKKQIQAAIEKLDYTPNAIASQLRAQSTNTIGVLVSRISNPFFAQLFDALERELNGYGFQVMVMQTHDDALAEQHFLDKLKQQQVDGVILASIENQQLVAQLSATYANQMVLLNEEATDIGIPMISLNHYQATKDALAYLYHQGHRRIAYATGGDFPSTHHGRSRTQAYLDFCEEQQLVVNNNWVFAQQHTIADGQALGKQLASLNPSDRPTAVFTNSDEVAVGVIDELQQQHFRVPDDMAVMGYDDQPFAAVAQVPLTTVRQPVAAMAQLAVDQLLHHLGRLQRPELAIDLSLDLIKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH1</accession>
    <name>F9UTH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, DUF20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890803.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3281"/>
    <dbReference type="EnsemblBacteria" id="CCC80289">
        <property type="protein sequence ID" value="CCC80289"/>
        <property type="gene ID" value="lp_3281"/>
    </dbReference>
    <dbReference type="GeneID" id="57026552"/>
    <dbReference type="KEGG" id="lpl:lp_3281"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2738"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053149_0_0_9"/>
    <dbReference type="OMA" id="ICTINTI"/>
    <dbReference type="PhylomeDB" id="F9UTH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2777-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="348" mass="39085" checksum="4A508BBAA3CC3BD1" modified="2011-10-19" version="1">MDRIIRFFKRDDVDLYLTLALLIIIIYLMRGFATVVLLTTIFAYLGIKLSRWLNLRTHLPYWIAVIVVYVGVIALFIGALSYAAPTLVDQLKVIPDMLAKAITNHPVLNKNIDKWVNQAIHSSELIQNGKALLVTGIKGLSEVGTGFTHVLMAIFLSFIFAVSRGRMMVFGRQFLQSKFKKFFTNVYYLTHKFVMILGRIIETQLVICTINTILMTIGFMIIGMPSIMVLSIIVFILGLVPVAGVLISMIPLTLLGFASGGLIRVVWIIVLVILIHAFESYFLHPRLMADRTDLPVFVTFITLIIMESLLGAWGLIIGIPIVSFFLDILGVQNSEPRRVTSQIAKREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTJ8</accession>
    <name>F9UTJ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642839.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80316">
        <property type="protein sequence ID" value="CCC80316"/>
        <property type="gene ID" value="lp_3318"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3318"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2767"/>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_8_1_9"/>
    <dbReference type="OMA" id="MRHPANI"/>
    <dbReference type="PhylomeDB" id="F9UTJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2807-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="33861" checksum="2A96735D8AB70561" modified="2011-10-19" version="1">MKTINLGHSNIQASSVALGIMRMDALDVAQATKVIDTAADLGINYVDSADIYGGGQSSTIFGQALKQAHVSRDQLYIQSKGGIVPGKRYDFSKQHILAAVDGELQRLGVDYLDTFLLHRPDALMEPEEVAAAFDKLQTSGKVRHFGVSNFNPMQVDMLQAALNQRLIINQLQFGIMHTGAIDFGLHTNMQDERSLNHDGEMIEYSRLHKMTIQAWSPYQYGNFAGIFLDNPKFPELNNAMQALADEKQVTKSAIATAWILRHPAHFQVVLGTMNPEHLAQNAAGADVTLSRQEWYDIYFAAGNDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK4</accession>
    <name>F9UTK4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-/zinc-/cobalt-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642848.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3327"/>
    <dbReference type="EnsemblBacteria" id="CCC80322">
        <property type="protein sequence ID" value="CCC80322"/>
        <property type="gene ID" value="lp_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3327"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2773"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_9"/>
    <dbReference type="OMA" id="AQVVIMN"/>
    <dbReference type="PhylomeDB" id="F9UTK4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2813-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="614" mass="64613" checksum="36F07099ACE8A17E" modified="2011-10-19" version="1">MRHYYKLILTVSVGIIAVILQFGLHYQLAAQIIITLMGSLMALSMLVEMIKTLRSGKYGVDLLAITAIVATLAVGEYWASLVVLIMLTGGDSLEDYAAKRANTELKALLDNSPRIAHRSVAGQLTDIAVEDVQIGDQLVVKPGELVPVDGHLIQGTALFDESSLTGESKPVDKHVGDDIMSGAVNGDSAVTMVVDKLAIDSQYQQLVKLVKESESRPAKFVRLADRYAVPFTLVAYVIAGVAWAFSGDPHRFAEVLVVASPCPLILAAPVALVSGMSRTSRNGIVVKTGDMLEKLSTAKSAAFDKTGTITSGQLTVNQIVPQPGFTAEQILHLAASAEQNSSHILARSLVKYASATSLSPATQLAEVTGNGVTATIEQQQVKVGKLKFVAPTTTAKPLATTAIYVGIDDQYAGYITFIDNVRPEAAATLQALHAEGVQNVMMLTGDQQAIADHIAADVGIDTVAADLLPADKIAHLKAVPAGERPVIMVGDGVNDAPSLAVADVGIAMGAHGSTAASESADVVILKDDLSRVVTAVRIAKDTMQVAKQAVWIGIAICTILMLIASTGIIPALFGAMLQEVVDTVSILWALRALRDRPQSSVSSTTTTPITKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL8</accession>
    <name>F9UTL8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102120.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890850.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3344"/>
    <dbReference type="EnsemblBacteria" id="CCC80336">
        <property type="protein sequence ID" value="CCC80336"/>
        <property type="gene ID" value="lp_3344"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3344"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2788"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_9"/>
    <dbReference type="OMA" id="ERTAQQP"/>
    <dbReference type="PhylomeDB" id="F9UTL8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2825-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15802" checksum="5BD2726771AC4672" modified="2011-10-19" version="1">MDNIGYLLMQFSKQLRYRLNQRLIANGLTIQQWAVMQQISLWVERTAQQPTANQLCHVLDMDRPTMSGILRRLAAKQLVEQEVNPADQRAKLLRLTQVGIQELQAGQHISDQVVATGLQKLTAAEKQSLRQLLKKLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP1</accession>
    <name>F9UTP1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641860.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888325.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0285"/>
    <dbReference type="DNASU" id="1061160"/>
    <dbReference type="EnsemblBacteria" id="CCC77811">
        <property type="protein sequence ID" value="CCC77811"/>
        <property type="gene ID" value="lp_0285"/>
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    <dbReference type="GeneID" id="66448378"/>
    <dbReference type="KEGG" id="lpl:lp_0285"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.239"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_4_0_9"/>
    <dbReference type="OMA" id="YSEFRVR"/>
    <dbReference type="PhylomeDB" id="F9UTP1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-233-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53697"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="243" mass="26937" checksum="679CF481F5D817C2" modified="2011-10-19" version="1">MFSYDQVQQLNRLEIEIYKYIVGHPAEVSTMTIRQLADHSHVSATTILRFLKHMGYDGYAEFKFTLKEQLRQDATQPLAQTVVPMRTFFDRMNLPDITAKLHRVAELVHQARMVVLIGSGTSAGLAAYGSHLFANFGLYSLMISDTSQPHPVQQQDLSDTVFFALSVSGESEDIIEQSVYYRQSGAKVVAITASSHSTLAGIADVVLTYDTPEVQAISGGSTLSQLPVVYYLEQLAMIIQPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR0</accession>
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    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100959.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0306"/>
    <dbReference type="EnsemblBacteria" id="CCC77830">
        <property type="protein sequence ID" value="CCC77830"/>
        <property type="gene ID" value="lp_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="57027117"/>
    <dbReference type="KEGG" id="lpl:lp_0306"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.259"/>
    <dbReference type="eggNOG" id="ENOG502ZAXQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076300_1_0_9"/>
    <dbReference type="OMA" id="YQITHHI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-252-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="34259" checksum="1F98ABCC9DC98055" modified="2011-10-19" version="1">MSTYYPYLRGRMYDLLALKTLCEQHQLGPHIIPVIEPVRDSKELQQTVTTFIEAQQPFSIIANPQVSVYGLNTVKLHPLPDLRPYPFYRPGAILAADFSRDFLTTSPGQTSLLIAPNYPLLKAYQHTTTLQHAGHVLIPDEARLHQLLPQHAVLLTDPVATPAHVADYQEITDAYFAPANWHQTPVGFDGFGDYSLMGRPYFDHGMPSRAIALHLIYVTVNGDLRIHHFVSDSNANMRGQKQKFFEALTKLTDWAPAHLTGLNRTPALATLLAYAEGDKFPGLGIIKKLAIMHHFQLMHRLLALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS9</accession>
    <name>F9UTS9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetoin ABC transporter, ATP-binding protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641901.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888363.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0326"/>
    <dbReference type="DNASU" id="1062163"/>
    <dbReference type="EnsemblBacteria" id="CCC77849">
        <property type="protein sequence ID" value="CCC77849"/>
        <property type="gene ID" value="lp_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="57027139"/>
    <dbReference type="KEGG" id="lpl:lp_0326"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.277"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="PhylomeDB" id="F9UTS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-271-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="33336" checksum="574C115053B503ED" modified="2011-10-19" version="1">MSLVINQLSKRIDHHQTLDGISFEIGLGQIVGVVGRNGVGKTTLFRTINGQYLTDHGQVLVDGQEVVDQPEMRTQLCFIDPLANFFKGATIAQIQWYYQAAYPDFDNAKFAQLLDRYHLTSKQKLRHFSKGMFGLFTIILSVATQAPYLFLDEPLDGLDVLIRKNILGILIDEVATGNRSIVIASHNLAELEGVIDRALMLKHGRIVNDYQLEAMRRSARKVQLVYRDKQIPAVVKQLGHIVHVSGRVIVVVFEDYNAEVQAQLATTNPVFQEDLPLSLADLFMANLTDEADFELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV2</accession>
    <name>F9UTV2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiA2</name>
        <name evidence="3" type="ordered locus">lp_0354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100974.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888386.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0354"/>
    <dbReference type="EnsemblBacteria" id="CCC77872">
        <property type="protein sequence ID" value="CCC77872"/>
        <property type="gene ID" value="lp_0354"/>
    </dbReference>
    <dbReference type="GeneID" id="57027163"/>
    <dbReference type="KEGG" id="lpl:lp_0354"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.299"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_9"/>
    <dbReference type="OMA" id="YFENIVH"/>
    <dbReference type="PhylomeDB" id="F9UTV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-294-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="23876" checksum="893B735274D50657" modified="2011-10-19" version="1">MTIKQAIVQQALTLIKPQMVVGFGGGSTVGELVKEAANHVNDITVVTPSPTTRQLATVLGYTVVDTAYCDRVDIAFDGCDQLDHHGNALKSGGGIHANEKIIASLADEYWLLTMQDRLVDQFDIKTPLVLEVLPAALSLVMRTVSDLGGQATIRTANNRDGFTLTDSGNLLIDCHFPTYAKLTDLNVELATLAGVVETSYFDHLVTNAWLGDATTNTVKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX1</accession>
    <name>F9UTX1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein, lysine-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888405.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0374"/>
    <dbReference type="EnsemblBacteria" id="CCC77891">
        <property type="protein sequence ID" value="CCC77891"/>
        <property type="gene ID" value="lp_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0374"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.318"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474714_0_0_9"/>
    <dbReference type="OMA" id="EKADMKH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-313-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027797">
        <property type="entry name" value="PT-TG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14449">
        <property type="entry name" value="PT-TG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389041" evidence="2">
        <location>
            <begin position="35"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PT-TG" evidence="3">
        <location>
            <begin position="303"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="595" mass="66563" checksum="C6166E02E7FD6F1D" modified="2011-10-19" version="1">MIKLRQVLKKILIGLMVFVLVFTAFSSSVDTVSAHRRGVTHTRKHKVRHSASGHAKKSHRAHRKAKRRVVHRKAPHRRKVAVRHKKKTPKRHKKAHKKKAAKKHKKSHKKKAVKKHKKSHKKKAAKKHKKSHKKKAAKKHKKSHKKKAAKKHKKSHKKKAAKKHGKSHKKKAAKKHKKSHKKKSSKKHGKSSKKKSSKKHGKSHKKKSSKKHGKSSKKKSSKKHGKSSKKKSSKKHGKSHKKKSSKKHGKSNKKKSSKKHGKSSKKKSSKKHGKSNKKKSSKKHASKGSAVIATLSRKTGISKGIISLLTDLVGYNDIYTMITGKDAATGKKRSRLVGAAWTALNFVPVSKVAKLAKAAKVLATAKKAEKVAKNGGRIKRAARATKLATKRAAEKLAKRKPARKTAKKAAEEARKAKKVKPAKKAKHQQAKPKKTSHGTKHKTTKKQQKRYNKKKAAGKARKASYARKKGGTKKKPGKRKGAKAKTTKRKTKNKVKRDNADTSKSVGNPVKVEGRGNTGRTKPNNLKEQMAMHQVQSNPLKGAKKLPVKMTDKRWPSEEGWVKMQNVITLGDGTKVNVHFVYNKITGKFDDFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ4</accession>
    <name>F9UTZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin peptide PlnK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plnK</name>
        <name evidence="1" type="ordered locus">lp_0405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888428.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UTZ4"/>
    <dbReference type="STRING" id="220668.lp_0405"/>
    <dbReference type="EnsemblBacteria" id="CCC77914">
        <property type="protein sequence ID" value="CCC77914"/>
        <property type="gene ID" value="lp_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0405"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.334"/>
    <dbReference type="eggNOG" id="ENOG5030BDK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2991065_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-337-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="57" mass="6293" checksum="1B5B086CBABBD124" modified="2011-10-19" version="1">MKIKLTVLNEFEELTADAEKNISGNRRSRKNGIGYAIGYAFGAVERAVLGGSRDYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU38</accession>
    <name>F9UU38_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101013.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888472.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0455"/>
    <dbReference type="EnsemblBacteria" id="CCC77958">
        <property type="protein sequence ID" value="CCC77958"/>
        <property type="gene ID" value="lp_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0455"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.375"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_1_9"/>
    <dbReference type="OMA" id="YYVIVTM"/>
    <dbReference type="PhylomeDB" id="F9UU38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-379-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="394" mass="42525" checksum="C01AD8CF743892E6" modified="2011-10-19" version="1">MKNVQKQVPSLLLLITLVGFPQISESIFTPILPALSQAMHVSASHSQITMSSYFVAFAVGVLFWGQYADYRGRRDAMLGGLAFYLIGNLGLYLSPGFTWLLVCRLIQAFGASAGSVVTQTIMRESFTGVTGAKIFAKVSAAMALSPALGPLIGGGVQTVFGYQHVFSVLIMIAVVILLYAGCCLPETRPETVKVASWRQQSVVVSRLLHDPVVWCYGLLISGINGILFSYYAEAPFIFETHFGFSAVQYGSLGLVLAAASLLGALLVNWLVNYWSPMQVALSGLGLSLVAAVGLVMTAVGNHVIGMLIGIFLAFLGLNITLPNALNRALIGYETVMGSASGWFSLGYYLLVSVLTYLMSWLHHGSIVTLPVYMLGVVVVMTVVYAGLYWRRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU60</accession>
    <name>F9UU60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P3 protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890876.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3377"/>
    <dbReference type="EnsemblBacteria" id="CCC80362">
        <property type="protein sequence ID" value="CCC80362"/>
        <property type="gene ID" value="lp_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3377"/>
    <dbReference type="HOGENOM" id="CLU_2585312_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2850-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="80" mass="9427" checksum="B3C07D9870BC2F25" modified="2011-10-19" version="1">MDKITIVLWVLAIGTTIFQYIAGYLKWSRCQWICPVLFSIFMLWFYFNGKDVSLISAVTAFIIGNIWYMAYAEMGKRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG7</accession>
    <name>F9UUG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890983.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3501"/>
    <dbReference type="EnsemblBacteria" id="CCC80469">
        <property type="protein sequence ID" value="CCC80469"/>
        <property type="gene ID" value="lp_3501"/>
    </dbReference>
    <dbReference type="GeneID" id="57026714"/>
    <dbReference type="KEGG" id="lpl:lp_3501"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2917"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9UUG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2957-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="32113" checksum="88633F737CA514E1" modified="2011-10-19" version="1">MTKSHPITISSWTLGDQCTFEDRCKAASAAGYDGIGLRAETYVDALNEGLTDDDILAILDKYNIRCTEVEYIVQWCEATRTYEQKYKEQACFHMCELFGVKHINTGLMEDYDIDYTAKKLQELAARAGDLIIALEPMPYSGLPNLDKTWKIMQKANCDNVYMLLDMWHWVRANQPYDLLTEEQAKRVISIQIDDAYTRPYADSILRDESMHDRLAPGAGDLDTAGFVKMIKDAGVDPKVIGVEVISDQYMAKGIDYVADYTYKQTVSVLKEAWPEILKDPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI3</accession>
    <name>F9UUI3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system fructose-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts31A</name>
        <name evidence="2" type="ordered locus">lp_3519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890999.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3519"/>
    <dbReference type="EnsemblBacteria" id="CCC80485">
        <property type="protein sequence ID" value="CCC80485"/>
        <property type="gene ID" value="lp_3519"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3519"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2933"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_5_0_9"/>
    <dbReference type="OMA" id="FDAPDEQ"/>
    <dbReference type="PhylomeDB" id="F9UUI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2973-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16288" checksum="A0E5D6D5E4A87645" modified="2011-10-19" version="1">MAMFTINNMNMNLEGHTQAEILVSLAELATSLNLVVDRDSLVKDYQEREQESTTGFGNGIAIPHAKSNNVKTAAILFGRSTTDIEWQSLDGKPVNTFISLLVPANEGDVHLKLLAQLSRKLVHQDFVEILKRGDTREVLEIINQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ1</accession>
    <name>F9UUJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system beta-glucoside-specific EIIBCA component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts33BCA</name>
        <name evidence="16" type="ordered locus">lp_3527</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891007.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3527"/>
    <dbReference type="EnsemblBacteria" id="CCC80493">
        <property type="protein sequence ID" value="CCC80493"/>
        <property type="gene ID" value="lp_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3527"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2941"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_2_9"/>
    <dbReference type="PhylomeDB" id="F9UUJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2981-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="107"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="535"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="666" mass="70352" checksum="BB4EDF581C0DC9B4" modified="2011-10-19" version="1">MMAYEDLSKKIIAGVGGKDNVKSVVHCTTRLRFKLKDESATHTDELKDTDGVITVVQSGGQYQVVIGNEVADVYETLIRVGGFADGGSVPDDYEDGEKMSIFDRFIDLISGIFTPMLGVLCAAGMIKGFVAMFVAFNWLSENSGTYKILYSIGDGFFYFLPIVLGLTAAKKFHVDQFVGMAIGMALCYPSIVALNSSKTVLSTLFSGSIFESQIHATFLGIPVVMMSYTSSVIPIILAVWFASKVQAFAKRIVPTVVKTFLVPFITLLIAVPITFLIIGPVASWLSDGISTVCVAIYNFSPIVAGLVMGAFWQVFVIFGVHWGFVAVMMANLASQGFDPILGLSLAASFAQTGVVLGILLQTKNQKTRGIALPAFISGIFGVTEPAIYGLTLPRKRPFILSCVAASIGGGIIGFAGTKMYMMGGMGLFSIPAAINSKTGVDGSVYGLIIAMAIAAVLGFALQMLFGYKSVDSNDKQTKVVETAATADPVMAGGVSVETTPTGAATKVEPNVTYNAATKLSSPETGQIIPLSEVKDEVFSSGAMGKGVAIEPTDGVLYAPADGEVALVFPTGHAVGLNTTDGAEILMHIGMDTVELEGKGFETLVQKGETVKAGQPLVKFDIEAIKAAGYPVTTPMVVTNSKNYHDVKLAFPAATEVNATEPLLQLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>P59391</accession>
    <accession>F9UKW9</accession>
    <name>ARGC1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase 1</fullName>
            <shortName evidence="1">AGPR 1</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase 1</fullName>
            <shortName evidence="1">NAGSA dehydrogenase 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC1</name>
        <name type="ordered locus">lp_0487</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101026.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888498.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59391"/>
    <dbReference type="SMR" id="P59391"/>
    <dbReference type="STRING" id="220668.lp_0487"/>
    <dbReference type="EnsemblBacteria" id="CCC77984">
        <property type="protein sequence ID" value="CCC77984"/>
        <property type="gene ID" value="lp_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0487"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.401"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_9"/>
    <dbReference type="PhylomeDB" id="P59391"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-405-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000112412" description="N-acetyl-gamma-glutamyl-phosphate reductase 1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <sequence length="339" mass="37212" checksum="0130254DFB3A6095" modified="2011-11-16" version="2">MKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHNLRFNHLDDLPFDLDFVFSALPTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPETLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIYAAYPLVKNKLINPNIFVDVKTGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIYASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEGQCIAVVSLDNLLKGAAGQAVQAANKYYQLVEDTGLDTLAGMWP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P77884</accession>
    <accession>F9URI4</accession>
    <name>PYRC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotase</fullName>
            <shortName evidence="1">DHOase</shortName>
            <ecNumber evidence="1">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrC</name>
        <name type="ordered locus">lp_2702</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="1"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644720.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890337.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="AlphaFoldDB" id="P77884"/>
    <dbReference type="SMR" id="P77884"/>
    <dbReference type="STRING" id="220668.lp_2702"/>
    <dbReference type="MEROPS" id="M38.972"/>
    <dbReference type="EnsemblBacteria" id="CCC79823">
        <property type="protein sequence ID" value="CCC79823"/>
        <property type="gene ID" value="lp_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2702"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2262"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_9"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="PhylomeDB" id="P77884"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2314-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000147237" description="Dihydroorotase">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="324"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91003." evidence="2" ref="1">
        <original>Q</original>
        <variation>H</variation>
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA91003." evidence="2" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="430" mass="45439" checksum="28AA854FC82946EF" modified="2003-03-25" version="2">MTTLIKNAQVWQAGQLQTTDILIAEGRIKAIGHQLHDQFGPADHVICADQHFVSPGFVDVHVHLRDPGQTAKETIATGTLAAAHGGFTTVGAMPNVDPVPDTPERVATMVARNQQEAHVHVAQYASITTGRTSEQLVDFAGIKAAGAFAVSNDGSGVQTAGTMFAAMQGAAKVGLPLAAHVEDDSLYHHGVMNAGPVADRLGLPGINNVSEAAQVARDVMLAEASGVHYHVCHVSTAESLRVIRNAKAAGINVTCEVSPHHLLLCDEDITMDNPMLKMNPPLRSAKDRAALVAGLLDGTIDMIATDHAPHTDAEKQGSMKTAAFGITGIETAFATLYTALVKTRLLTLGRLIELMSTRPAELFGLNTAGRLVVGAPADLTIIDLDHQYEIEAATMLSKGHNSPFIGWPVYGNVLMTLVDGKLAYGKETQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE1</accession>
    <accession>F9UR73</accession>
    <name>HIS5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisH</fullName>
            <shortName evidence="1">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisH</name>
        <name type="ordered locus">lp_2557</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101826.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE1"/>
    <dbReference type="SMR" id="Q88UE1"/>
    <dbReference type="STRING" id="220668.lp_2557"/>
    <dbReference type="EnsemblBacteria" id="CCC79712">
        <property type="protein sequence ID" value="CCC79712"/>
        <property type="gene ID" value="lp_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2557"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2148"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_9"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="PhylomeDB" id="Q88UE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2204-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152382" description="Imidazole glycerol phosphate synthase subunit HisH">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <sequence length="208" mass="22347" checksum="CCCA1CCF9F2C37B7" modified="2003-06-01" version="1">MFAIVDYDTGNTRNLKKAFDYLQVSTILTADPQQLAAADAVILPGVGAFAAAMAALKERQLVGVLQALARSGKPVLGICLGMQLLFESSSEYGEHAGLGLLSGRVSALPTDLNVKVPQMGWNQNELRRPDSPFASIDAAYTYFVHSYYAVCPATEIVATVQHGVQVPSIVQQQNVIGMQFHPEKSGRVGLQQLAAFKEMVSANDFSSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE4</accession>
    <accession>F9UR70</accession>
    <name>HIS3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="1">PRA-CH</shortName>
            <ecNumber evidence="1">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisI</name>
        <name type="ordered locus">lp_2553</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE4"/>
    <dbReference type="SMR" id="Q88UE4"/>
    <dbReference type="STRING" id="220668.lp_2553"/>
    <dbReference type="EnsemblBacteria" id="CCC79709">
        <property type="protein sequence ID" value="CCC79709"/>
        <property type="gene ID" value="lp_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2553"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2145"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_3_9"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="PhylomeDB" id="Q88UE4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2201-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000136478" description="Phosphoribosyl-AMP cyclohydrolase">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <sequence length="108" mass="11967" checksum="C0D47625E0B29526" modified="2003-06-01" version="1">MKPDFEKGDGLLTTVVTDADTKDVLMVAWMNAESYQRTLASGQTWFWSRSRQELWHKGATSGNLQDVVSMTLDCDQDTLLVAVHPHGPACHTGHTSCFFNPVELEQGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UI3</accession>
    <accession>F9UR32</accession>
    <name>Y2503_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Putative sugar uptake protein lp_2503</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2503</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642758.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890185.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UI3"/>
    <dbReference type="SMR" id="Q88UI3"/>
    <dbReference type="STRING" id="220668.lp_2503"/>
    <dbReference type="DNASU" id="1062677"/>
    <dbReference type="EnsemblBacteria" id="CCC79671">
        <property type="protein sequence ID" value="CCC79671"/>
        <property type="gene ID" value="lp_2503"/>
    </dbReference>
    <dbReference type="GeneID" id="57025935"/>
    <dbReference type="KEGG" id="lpl:lp_2503"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2108"/>
    <dbReference type="eggNOG" id="COG4975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076024_0_0_9"/>
    <dbReference type="OMA" id="GHEPFAK"/>
    <dbReference type="PhylomeDB" id="Q88UI3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2163-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213653" description="Putative sugar uptake protein lp_2503">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="285" mass="30272" checksum="87E12EF6E0C7B3A0" modified="2003-06-01" version="1">MGILIALIPAIAWGSIGLISGRMGGTARQQTLGMTMGALVFGLALWAVEQPTLTSKIWLIGIVSGLFWSIGQGQQFTSMKAVGISRTTPISTGMQLVANALAGVLLFNEWHGNMYWIGSASVIVLIAGAVLTSLTDKTDPNRSASENWGVGIRALILSTIGYAGYTIVVHYGNVNAQAVVMPQAVGMLLGALIWSFKDKPWVVKATYRNIVTGLVWGIGNLFMFMAMAQIGQAVAYSLSQMGIVISTFGSIYLLGEHKTKREMVYVVIGSILVIVGGVALSLMKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UW9</accession>
    <accession>F9UQN7</accession>
    <name>Y2332_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0637 protein lp_2332</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2332</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0637 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101714.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890040.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UW9"/>
    <dbReference type="SMR" id="Q88UW9"/>
    <dbReference type="STRING" id="220668.lp_2332"/>
    <dbReference type="EnsemblBacteria" id="CCC79526">
        <property type="protein sequence ID" value="CCC79526"/>
        <property type="gene ID" value="lp_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2332"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1971"/>
    <dbReference type="eggNOG" id="COG4493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096059_0_0_9"/>
    <dbReference type="OMA" id="YKKLPHF"/>
    <dbReference type="PhylomeDB" id="Q88UW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2010-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01851">
        <property type="entry name" value="UPF0637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009403">
        <property type="entry name" value="UPF0637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06335">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021332">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000348306" description="UPF0637 protein lp_2332">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01851"/>
        </source>
    </evidence>
    <sequence length="208" mass="23474" checksum="D029DBFBB12BF2A3" modified="2003-06-01" version="1">MFTNQDFEIFNDQTLAGRMHLIKTVIDPKFEQVAPTIITSLQTPGEPPFYAHVAKHLRRFKNPPVDTWVAFSQNKRSYKAWPHFELGLWPDRLFIYFDILDECKPAVQAKMQLADLTPLLKALPAGYVISNNHGVPATQLATPANITQAIKKFNQYKHSELVVGRAVLVGDPLFENADTLNKLIIATFKQLLSIYQPVMAAVSAERQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V16</accession>
    <accession>F9UQJ0</accession>
    <name>MUTS2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease MutS2</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS2</name>
        <name type="ordered locus">lp_2271</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101700.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889993.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V16"/>
    <dbReference type="SMR" id="Q88V16"/>
    <dbReference type="STRING" id="220668.lp_2271"/>
    <dbReference type="PRIDE" id="Q88V16"/>
    <dbReference type="DNASU" id="1061270"/>
    <dbReference type="EnsemblBacteria" id="CCC79479">
        <property type="protein sequence ID" value="CCC79479"/>
        <property type="gene ID" value="lp_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2271"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1922"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_9"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="PhylomeDB" id="Q88V16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1964-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000093370" description="Endonuclease MutS2">
        <location>
            <begin position="1"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="712"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <sequence length="787" mass="87220" checksum="F059F850A3E7BC39" modified="2003-06-01" version="1">MNSKVLNTLEYQQVKQQLAPYLVSATGQQALNELHPMTSVADIQRALDETNDGAEVYRLKGGIPVARLADIKPHMKRLAIGATLNGSELGQVGRVLRTTRAITRFFAELLEDAPENDIRHLFDEVAELVTLPDVTKRLATAIEGDGHITDEASPELSRIRSNIRRTETEIRNQMGHYTRGHDAKYLSDPIITIRNDRYVIPVKAENRSRFGGIVHDQSASGQTLFIEPQAVMAMNDRLRQNQVAEKQEEQRILEELSNLIAPYQDEIINNAAILGHFDFINAKARYAHDMKATEPAVSPQNEVYLRQARHPLIDPRKVVANDISLGTDYQAMVITGPNTGGKTITLKTLGLLQLMAQSGLFIPVEAGSRVGVYNEIFADIGDEQSIEQNLSTFSSHMENIESFLAQIDAHSLVLVDELGAGTDPQEGAALAIAILDAIGAKGTQVVATTHYPELKAYGFNRPDTINASMEFDEETLKPTYRLLVGIPGRSNALDIAQRLGIPQAIVDQARSLTDTDSQDLNAMIADLVTKRKQVEDEQLHLKTQVADSEKLHRQLKSEFNAYQQRKDQLIEDAKVQANTIVEQSKTKADAIISDLRKKQLASGTATVKENELIDAKGALNALEQQPKLKKNRVLRRAKAQHDFHEGDDVLVKSYGQRGVLMRQMGKHEWEVQLGILKMKISDGDLERVKPEEPKRARATVQSAHASHVSPNLDLRGVRYEDAMTQVDRYIDAALLAGYPSVTIVHGKGTGALREGITNYLKSNRQVKSFHFAAPNHGGNGATEVQFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VC6</accession>
    <accession>F9UQ79</accession>
    <name>Y2135_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0298 protein lp_2135</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2135</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0298 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640811.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889882.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VC6"/>
    <dbReference type="SMR" id="Q88VC6"/>
    <dbReference type="STRING" id="220668.lp_2135"/>
    <dbReference type="EnsemblBacteria" id="CCC79368">
        <property type="protein sequence ID" value="CCC79368"/>
        <property type="gene ID" value="lp_2135"/>
    </dbReference>
    <dbReference type="GeneID" id="57025674"/>
    <dbReference type="KEGG" id="lpl:lp_2135"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1809"/>
    <dbReference type="eggNOG" id="COG4471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159890_0_1_9"/>
    <dbReference type="OMA" id="IKQYKFV"/>
    <dbReference type="PhylomeDB" id="Q88VC6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1829-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01126">
        <property type="entry name" value="UPF0298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016979">
        <property type="entry name" value="DUF2129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09902">
        <property type="entry name" value="DUF2129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031653">
        <property type="entry name" value="UCP031653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000074659" description="UPF0298 protein lp_2135">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01126"/>
        </source>
    </evidence>
    <sequence length="100" mass="11805" checksum="15262B1E6D2DB394" modified="2003-06-01" version="1">MDFTVKPRRSLIVYMHSMKQVRQLKRFGLIQYQSRKEHYVVLYMDESQIPAATTKIKKLNFVRRVEPSYRPDVAMNFGERVDQGFFKPTTTGAPDDDDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W75</accession>
    <accession>F9UPC8</accession>
    <name>LSPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="ordered locus">lp_1780</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889581.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W75"/>
    <dbReference type="SMR" id="Q88W75"/>
    <dbReference type="STRING" id="220668.lp_1780"/>
    <dbReference type="EnsemblBacteria" id="CCC79067">
        <property type="protein sequence ID" value="CCC79067"/>
        <property type="gene ID" value="lp_1780"/>
    </dbReference>
    <dbReference type="GeneID" id="57025393"/>
    <dbReference type="KEGG" id="lpl:lp_1780"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1501"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_3_9"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="PhylomeDB" id="Q88W75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1530-MON"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178788" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <sequence length="149" mass="16765" checksum="B9676CC8AD45CA40" modified="2003-06-01" version="1">MWIYLILMVALVIIDQVIKAAIVSHIALGASTSIVTGLLSLTNLHNNGAAWSILEGKMWFFYLISVIALIVMGYLLWRLRGKWLYEVGISLMIAGTLGNFIDRLRIGYVVDMFQLDFINFPIFNFADSCLTVGVIFILIGVLRDDSFEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WB6</accession>
    <accession>F9UP87</accession>
    <name>IDI2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="1">IPP isomerase</shortName>
            <ecNumber evidence="1">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="1">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fni</name>
        <name type="ordered locus">lp_1732</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644359.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889540.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WB6"/>
    <dbReference type="SMR" id="Q88WB6"/>
    <dbReference type="STRING" id="220668.lp_1732"/>
    <dbReference type="EnsemblBacteria" id="CCC79026">
        <property type="protein sequence ID" value="CCC79026"/>
        <property type="gene ID" value="lp_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1732"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1461"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_0_0_9"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="PhylomeDB" id="Q88WB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1489-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000134411" description="Isopentenyl-diphosphate delta-isomerase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <sequence length="348" mass="38014" checksum="1FB1D38CDF2F301A" modified="2003-06-16" version="1">MPQSQQSHRKDEHVSLAEKYFHGEQANAFDQVRIRHDALPETAVADVDLATTVGQWHWDSPLYIEAMTGGSQRTGEINARLGRIAAACGLPIATGSQSVAIKDPQVAPTFATMRDHNPNGLIFGNLGAGHPLSAAQTAIAMLQADALELHLNVVQEIVMPEGDRDFHWLTNISDLVQALTVPVIVKEVGFGISRPTMQQLYAAGVRYLDLGGHGGTNFVDIENRRRANRDMAYLHDFGLTTVESLLGVQNRPDDLTVLAAGGVRQPLDILKALMLGADAVGMAGTVLHALLHHTDDEVIAMLTDWQSQLKRLFALVGVTRVDQFKSSRIQDKILLSPELVNYKQSIKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WK9</accession>
    <accession>F9UNZ4</accession>
    <name>RSGA1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit biogenesis GTPase RsgA 1</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsgA1</name>
        <name type="ordered locus">lp_1620</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889447.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WK9"/>
    <dbReference type="SMR" id="Q88WK9"/>
    <dbReference type="STRING" id="220668.lp_1620"/>
    <dbReference type="EnsemblBacteria" id="CCC78933">
        <property type="protein sequence ID" value="CCC78933"/>
        <property type="gene ID" value="lp_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1620"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1368"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_9"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="PhylomeDB" id="Q88WK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1395-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000171483" description="Small ribosomal subunit biogenesis GTPase RsgA 1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <sequence length="298" mass="32953" checksum="B3C296AF4F89C6E8" modified="2003-06-01" version="1">MKIGQIRQSLSGFYDVYADGQMYRTRARGNFRKRRITPLVGDNVEFDAATPQEGYVLNILDRQTQLVRPPVANVDLGIVVTATTEQEFSTNLLDRQLVALAVAGIEPLLYFAKTDLLTDEVYQQRLTLADAYRQIGYQVICERTAFSPAALAAVKTALAGHVAVVMGQTGAGKSTLLNHLQPGLALATGEISQALNRGKHTTRKVSLIPIADGLVADTPGFSSYEVFDIAANELTHYFPEFVRLSVDCKYRGCVHINEPQCAVKQALAAGELLASRYDNYLQFYETIKNKKVIYNKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WL6</accession>
    <accession>F9UNY7</accession>
    <name>RPOZ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="1">RNAP omega subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoZ</name>
        <name type="ordered locus">lp_1613</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640362.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WL6"/>
    <dbReference type="SMR" id="Q88WL6"/>
    <dbReference type="STRING" id="220668.lp_1613"/>
    <dbReference type="EnsemblBacteria" id="CCC78926">
        <property type="protein sequence ID" value="CCC78926"/>
        <property type="gene ID" value="lp_1613"/>
    </dbReference>
    <dbReference type="GeneID" id="57025196"/>
    <dbReference type="GeneID" id="66449496"/>
    <dbReference type="KEGG" id="lpl:lp_1613"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1361"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125406_6_0_9"/>
    <dbReference type="OMA" id="KYTIVTV"/>
    <dbReference type="PhylomeDB" id="Q88WL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1388-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000128946" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <sequence length="70" mass="7743" checksum="BB858EE425B8B9A6" modified="2003-06-20" version="1">MILYPSVDDLLKQVNSRYSLIMLASKRAHELDAGAAPMLSEYKSVKTIGRAMEEIAAGDLMIDPDETDKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WM7</accession>
    <accession>F9UNX5</accession>
    <name>EX7L_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="1">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseA</name>
        <name type="ordered locus">lp_1600</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889428.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WM7"/>
    <dbReference type="STRING" id="220668.lp_1600"/>
    <dbReference type="EnsemblBacteria" id="CCC78914">
        <property type="protein sequence ID" value="CCC78914"/>
        <property type="gene ID" value="lp_1600"/>
    </dbReference>
    <dbReference type="GeneID" id="66449484"/>
    <dbReference type="KEGG" id="lpl:lp_1600"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1349"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_9"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="PhylomeDB" id="Q88WM7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1376-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000197853" description="Exodeoxyribonuclease 7 large subunit">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <sequence length="447" mass="50494" checksum="A824B304142622A3" modified="2003-06-06" version="1">MSESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISAIMFKSAFAKVKFQPEEGMKVLVVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKKLAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTRRRFPIAQIVLFPSQVQGDAAAAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETDTTIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQTSYVFTQPNRLYEGYLQKLDFLNERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQTQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKIMTRGYAFVTADEQVVHGVKQLQPEQTVAIHMADGEAQAQITKIDGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XB8</accession>
    <accession>F9UN80</accession>
    <name>METK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">lp_1301</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101345.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XB8"/>
    <dbReference type="SMR" id="Q88XB8"/>
    <dbReference type="STRING" id="220668.lp_1301"/>
    <dbReference type="EnsemblBacteria" id="CCC78669">
        <property type="protein sequence ID" value="CCC78669"/>
        <property type="gene ID" value="lp_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1301"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1101"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_9"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="PhylomeDB" id="Q88XB8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1127-MON"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000174536" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="395" mass="42679" checksum="8684E0C45E8FC828" modified="2003-06-01" version="1">MSERHLFTSESVSEGHPDKIADQISDAILDAMLAQDPQARVAVETSVTTGLVLVFGEVSTKAYVDIQKVVRDTIKSIGYVDGQYGFDGDNCAVLVSLDEQSPDIAQGVDDSLETRSGDADPLDQIGAGDQGMMFGYAINETPELMPLPIALSHRLMRKIAALRKDGTIKWLRPDAKAQVTVEYDEDNQPKRIDTVVLSTQHDPDVDLDTIRQTVIDQVIKAVLPADLLDDQTKYLVNPTGRFVIGGPQGDAGLTGRKVIVDTYGGFAHHGGGAFSGKDATKVDRSASYAARYIAKNVVAAGLADQVEVQLAYAIGVAEPVSIAVDTAGTGKVSDEALINAIRENFDLRPAGIIKMLDLQRPIYRQTAAYGHFGRTDIDLPWEHTDKVDALKAVFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX2</accession>
    <accession>F9UML9</accession>
    <name>RS8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">lp_1050</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX2"/>
    <dbReference type="SMR" id="Q88XX2"/>
    <dbReference type="STRING" id="220668.lp_1050"/>
    <dbReference type="EnsemblBacteria" id="CCC78458">
        <property type="protein sequence ID" value="CCC78458"/>
        <property type="gene ID" value="lp_1050"/>
    </dbReference>
    <dbReference type="GeneID" id="57024705"/>
    <dbReference type="GeneID" id="66448961"/>
    <dbReference type="KEGG" id="lpl:lp_1050"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.885"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_9"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="PhylomeDB" id="Q88XX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-901-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126425" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="131" mass="14643" checksum="7B77D02489927BC9" modified="2003-06-01" version="1">MMTDPIADFLTRIRNANMVRHDSLEVPASKIKRNIAEILKNEGFVRDVEYIDDDKQGIIRVFLKYGKDNERVISGLKRISKPGLRSYVKADAVPKVLNGLGIAIISTSEGVITDKEARAKKLGGEVLAYVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YK3</accession>
    <accession>F9ULY1</accession>
    <name>HPRK_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr kinase/phosphorylase</fullName>
            <shortName evidence="1">HPrK/P</shortName>
            <ecNumber evidence="1">2.7.11.-</ecNumber>
            <ecNumber evidence="1">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hprK</name>
        <name type="ordered locus">lp_0754</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="1"/>
    <dbReference type="EC" id="2.7.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888734.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YK3"/>
    <dbReference type="SMR" id="Q88YK3"/>
    <dbReference type="STRING" id="220668.lp_0754"/>
    <dbReference type="EnsemblBacteria" id="CCC78220">
        <property type="protein sequence ID" value="CCC78220"/>
        <property type="gene ID" value="lp_0754"/>
    </dbReference>
    <dbReference type="GeneID" id="57024454"/>
    <dbReference type="GeneID" id="66448722"/>
    <dbReference type="KEGG" id="lpl:lp_0754"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.635"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_9"/>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="PhylomeDB" id="Q88YK3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-655-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000058963" description="HPr kinase/phosphorylase">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="1">
        <location>
            <begin position="266"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <sequence length="315" mass="34872" checksum="48A8911ADBF0F57A" modified="2003-06-01" version="1">MAGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKTETAYSKNMSHDERLMIFRKMCQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSRILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVGKSETALELVKRGHRLIADDRVDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPDKQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDNLNKLIKTNSVHDSHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZH4</accession>
    <accession>F9UTU4</accession>
    <name>TAGH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Teichoic acids export ATP-binding protein TagH</fullName>
            <ecNumber evidence="1">7.5.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tagH</name>
        <name type="ordered locus">lp_0344</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + teichoic acidSide 1 = ADP + phosphate + teichoic acidSide 2.</text>
            <dbReference type="EC" id="7.5.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (TagH) and two transmembrane proteins (TagG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3.A.1.104.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641921.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888378.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZH4"/>
    <dbReference type="SMR" id="Q88ZH4"/>
    <dbReference type="STRING" id="220668.lp_0344"/>
    <dbReference type="EnsemblBacteria" id="CCC77864">
        <property type="protein sequence ID" value="CCC77864"/>
        <property type="gene ID" value="lp_0344"/>
    </dbReference>
    <dbReference type="GeneID" id="57027155"/>
    <dbReference type="GeneID" id="66448440"/>
    <dbReference type="KEGG" id="lpl:lp_0344"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.292"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_8_9"/>
    <dbReference type="OMA" id="VHIVYRV"/>
    <dbReference type="PhylomeDB" id="Q88ZH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-286-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015438">
        <property type="term" value="F:ABC-type teichoic acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51251">
        <property type="entry name" value="TAGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092991" description="Teichoic acids export ATP-binding protein TagH">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Unknown">
        <location>
            <begin position="247"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01715"/>
        </source>
    </evidence>
    <sequence length="363" mass="40841" checksum="BCC6704BC7EC285C" modified="2003-06-01" version="1">MENQYKVELHNVTKEYDLYRSNNDKLKHFFNIGNVDVPRFWSLKGVSLNVKPGEALGIIGINGSGKSTISNIISGIIPQTTGTVDVHGDTSIISIGAGLKWNLTGDENIRLKGLMQGLSIKEIQAVRDDIVDFADIGDFIGQPVKDYSTGMRSRLGFAIAVHINPDIMIIDEALSVGDDTFYQKCVDKIMEFKKQGKTIIFVSHNLRQVELLCDRVAWMHFGDLLEVGETKETVDHYRKFSKDFKAQTAAYRKKYQVGKKKEQADFDIVAYERQLVEEKAKDSDKSKQAVSRQVHRTLYKQILPEKMTIATKLVMLVAIVLFVFFALVNVSGHSVTSAIENPTVLLHPVNHYIKSQSVLFNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX9</accession>
    <name>F9UKX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose mutarotase</fullName>
            <ecNumber evidence="1">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoM</name>
        <name evidence="1" type="ordered locus">lp_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888508.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0499"/>
    <dbReference type="EnsemblBacteria" id="CCC77994">
        <property type="protein sequence ID" value="CCC77994"/>
        <property type="gene ID" value="lp_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0499"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.411"/>
    <dbReference type="eggNOG" id="ENOG502Z97R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070797_0_0_9"/>
    <dbReference type="OMA" id="NYATRWI"/>
    <dbReference type="PhylomeDB" id="F9UKX9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-415-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="338" mass="38149" checksum="274856962F761B42" modified="2011-10-19" version="1">MKTIKLSHQMFSQSEFELYKDDNFSAKTFLYPSGVEGLRLTNQRGELVVLPFMGLIIWDVVFDGISLKMKDMFSQPLPGKGIADTYGCFQFTSGLLGNGTPAPEDDYQLHGEFPTSKMAHTYLTIGEDTLTIHADFEYVKGFGDHYLSEPSVMMRANSGLFDINLDVTNLSHAQAMPLQYMCHMNYAYAKNAHIEQNLPDEAFKLRKTVPAHVHPTDAWLAYNDQLKASGELINDLTDEAHYDPEIVFFSRDLTQYTDEAEFRMHLDDSHNFLTKFKTEQFPIVTRWLLYNADQQVAAFALPGTSTPEGKAAATKAGTLIMLEPQAKRHFSVTTGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA8</accession>
    <name>F9ULA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891029.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3552"/>
    <dbReference type="EnsemblBacteria" id="CCC80515">
        <property type="protein sequence ID" value="CCC80515"/>
        <property type="gene ID" value="lp_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3552"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2962"/>
    <dbReference type="eggNOG" id="COG5506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111531_0_1_9"/>
    <dbReference type="OMA" id="SEAMRYD"/>
    <dbReference type="PhylomeDB" id="F9ULA8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3003-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012543">
        <property type="entry name" value="DUF1694"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07997">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034303">
        <property type="entry name" value="DUF1694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="132" mass="15590" checksum="7E2230AB26AFF45B" modified="2011-10-19" version="1">MQNKDLDIDARVKNAVLGLPLLKPDEQNRCLGTFYERIELKITISEAMRYDWTTILEKVMKKKRNYQLLFNGRLDMEILGQYIRLANRCAMPFAIKNSQHYRHNAESAAIILCADHALNRKEIDIMKRYPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF6</accession>
    <name>F9ULF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891077.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3602"/>
    <dbReference type="EnsemblBacteria" id="CCC80563">
        <property type="protein sequence ID" value="CCC80563"/>
        <property type="gene ID" value="lp_3602"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3602"/>
    <dbReference type="HOGENOM" id="CLU_2409572_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3050-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="10758" checksum="5020FB06066335F4" modified="2011-10-19" version="1">MNITKTMFKKKLFWSILLFLDVVLFIEALSTNSISACIVVMIISETIYFKGNHILFGEFDTKRHAKREQYKKNCLKKRTLDHSSKSKEIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG3</accession>
    <name>F9ULG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myo-inositol (And similar sugars) transporter,major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iolT2</name>
        <name evidence="10" type="ordered locus">lp_3611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3611"/>
    <dbReference type="EnsemblBacteria" id="CCC80570">
        <property type="protein sequence ID" value="CCC80570"/>
        <property type="gene ID" value="lp_3611"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3611"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3013"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_9"/>
    <dbReference type="OMA" id="SCHEQEM"/>
    <dbReference type="PhylomeDB" id="F9ULG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3057-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="33"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="488" mass="53511" checksum="C89AE6A7527DEA2F" modified="2011-10-19" version="1">MSAEKSISSDHVPLSDPALKTINRNAGRNLNHIAFISTLGGLLFGVDTGVINGAIGYMATPAELNLSPNNEGLVTSGITLGAAFGAVFAGHLSDRIGRKRLLKYLALLFFVCTLACSLAPNALFMIISRVLLGLAVGGASVIVPTYLSEISTPEIRGRLVTQNELMIVTGQLLAFIVNAILGNWFGHISNIWRYMIGFGMIPAVALFFGMMVVPESPRWLVMVNQLDNAFDSLRKIRSHPETCNEEITQIQDTLNQESEIKQATFKDLSTPWIRRLVFIGIGLGVMQQFIGINIMMYYGTTILTNSGFAHNAALIANIGNGLVSVIATFIGMSIMNRVNRRSMLIAGIIGTTTSLILIVGVSAFLSQSPLLPILVVLCTMMFLGFFQGFISPLVWLLLSEIFPQNLRGLGMGVSTFFLWFANFLVGYFFPILLSAVGMTWTFLIFVFFNILSFIFAYKYAPETRGKSLELIQMEFKYGDTTGINPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG7</accession>
    <name>F9ULG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-uridine nucleoside N-ribohydrolase</fullName>
            <ecNumber evidence="4">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891088.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3615"/>
    <dbReference type="EnsemblBacteria" id="CCC80574">
        <property type="protein sequence ID" value="CCC80574"/>
        <property type="gene ID" value="lp_3615"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3615"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3017"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_9"/>
    <dbReference type="OMA" id="REKAHEW"/>
    <dbReference type="PhylomeDB" id="F9ULG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3061-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="311" mass="34020" checksum="263D9F9E155D3FF3" modified="2011-10-19" version="1">MEDIILDCDPGHDDAVALMIAIASKDINLLAVTTSAGNQRHSQTLRNAMSLLTLMKRQDIPVASGNTKPLMRSLISGVSMHGVTGLDGADLPSPDFFSQGIPAIELIAKILTDHPQKVTLVVTGPCTNIALFLSVHPELRSRIKQIVILGGGMGLGNWGPTTEFNIQVDPEAAKIVLDSGIPIILAPLNVAFEAQLLPNEIEKIHNIDNSVAQTISGLMDFYGISFGRQRWGFKGLPLYDPCTVAWLIDPSKFTSKRCNVEVETKGELTTGETVIDYYHITNRKPNAEVLFHIDRQWFADLTISSIKSFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG8</accession>
    <name>F9ULG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tal3</name>
        <name evidence="2" type="ordered locus">lp_3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3617"/>
    <dbReference type="EnsemblBacteria" id="CCC80575">
        <property type="protein sequence ID" value="CCC80575"/>
        <property type="gene ID" value="lp_3617"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3617"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3019"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_2_0_9"/>
    <dbReference type="OMA" id="PRKTHIA"/>
    <dbReference type="PhylomeDB" id="F9ULG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3062-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="25160" checksum="8A7237FA61036D32" modified="2011-10-19" version="1">MELLLDTVNLDTIKKYADVISLAGVTSNPSIVKKERPIDFYKHMREVRQIIGKERTLHVQVVGQTAEAMLADAHMILEELDDQVYIKVPTDMTGLAVIKQLKKEDIHVTATAIYSEFQGYLAIAAGVDYLAPYYNRMINMNIDSDLVIKHLANQIQREQSTTKILAASFHTVQQINASLVMGAQAVTLGPDLLETALNSPAISAVVAGFKADWESLYGANATLASLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULJ1</accession>
    <name>F9ULJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein,mannose-related oligosaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643598.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891112.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3643"/>
    <dbReference type="EnsemblBacteria" id="CCC80598">
        <property type="protein sequence ID" value="CCC80598"/>
        <property type="gene ID" value="lp_3643"/>
    </dbReference>
    <dbReference type="GeneID" id="57026824"/>
    <dbReference type="GeneID" id="66451071"/>
    <dbReference type="KEGG" id="lpl:lp_3643"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3042"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="OMA" id="VMIQLVQ"/>
    <dbReference type="PhylomeDB" id="F9ULJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3085-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="34240" checksum="544E6DE08BEFF92F" modified="2011-10-19" version="1">MRKKKHISAVEIRKFGPGANLFFNIFLAIFALSCILPFFFIIILSLTQESDITTYGYQFWPKHWTFASYQYLAKMGHQVLVSLGVTIFVTVVGTIMNSLFSSTYAYAISRKDFAYARFFTIFALISMLFVPGMVPTYLVVTQMLGLQDNIWALILPMSFGVYNVLIMRTFFKTSIPEAIIESARIDGGSELRIFRSIVVPLAIPGIATISLFTSLGYWNDWMNALLYINKDSVTPLQYLLIKIQNNIQFMTQNMQANGAIAGAANVPSEGMRFAIVVVATLPIALTYPFFQKYFVKGMTIGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ9</accession>
    <name>F9ULQ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888662.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0671"/>
    <dbReference type="EnsemblBacteria" id="CCC78148">
        <property type="protein sequence ID" value="CCC78148"/>
        <property type="gene ID" value="lp_0671"/>
    </dbReference>
    <dbReference type="GeneID" id="57025303"/>
    <dbReference type="KEGG" id="lpl:lp_0671"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.563"/>
    <dbReference type="eggNOG" id="ENOG5030A8X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127609_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-582-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024410">
        <property type="entry name" value="Phage_TAC_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12363">
        <property type="entry name" value="Phage_TAC_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024865">
        <property type="entry name" value="UCP024865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19162" checksum="5D32B2BBA376834B" modified="2011-10-19" version="1">MENLMIDGTTCTPKLNYAFANQVKKELSADGRDGFDVLVDGLLDEDPEQIVNAYYYALAYFKRSQPSRDKVVEALEDTIFADDDKTNAAYSDIIQSLHADNFLARKLTSFVKGYNKILDIMQKKLDSEKEGSDQYNKDQLGMEQLQTQLDKLNKVLQPGTPQLVTPEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS1</accession>
    <name>F9ULS1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P1 protein 60, holin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0683"/>
    <dbReference type="EnsemblBacteria" id="CCC78160">
        <property type="protein sequence ID" value="CCC78160"/>
        <property type="gene ID" value="lp_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0683"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.575"/>
    <dbReference type="eggNOG" id="COG5546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1990525_0_0_9"/>
    <dbReference type="OMA" id="FGIKFAG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-594-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006485">
        <property type="entry name" value="Phage_holin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04531">
        <property type="entry name" value="Phage_holin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="119" mass="12409" checksum="1D3579A580723ED8" modified="2011-10-19" version="1">MKKISLKNADGSFNGKLIAGIISLLIVLIQQILAVFGIKFAGDWTSIVAVVNTVLTILGMLGVITDVQTVNVSEDATGTLEQATNEVDSTSQADKAPTSASVSNVTDISADVKVDDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV3</accession>
    <name>F9ULV3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimI2</name>
        <name evidence="3" type="ordered locus">lp_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0720"/>
    <dbReference type="EnsemblBacteria" id="CCC78192">
        <property type="protein sequence ID" value="CCC78192"/>
        <property type="gene ID" value="lp_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="57024427"/>
    <dbReference type="KEGG" id="lpl:lp_0720"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.605"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_2_9"/>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="PhylomeDB" id="F9ULV3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-627-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="17097" checksum="8744B2EF9A5F3E47" modified="2011-10-19" version="1">MTERQLVASTQLDAGRAVQVCYQLATLAYPGGAPWRQATFAADMALPTVHYDLLRWQDELIGFVSRSTVLDETEITNIAIDPAYQRQGHARWLLTACLAQLSAGSVFLEVRASNLAAQRLYQQCGFDQIATRKEYYHDPEEDAWIMRKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ4</accession>
    <name>F9ULZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641027.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888747.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0770"/>
    <dbReference type="DNASU" id="1063743"/>
    <dbReference type="EnsemblBacteria" id="CCC78233">
        <property type="protein sequence ID" value="CCC78233"/>
        <property type="gene ID" value="lp_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0770"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.650"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_9"/>
    <dbReference type="OMA" id="LYADSFH"/>
    <dbReference type="PhylomeDB" id="F9ULZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-668-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="8"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="43350" checksum="C770B9751A5BE391" modified="2011-10-19" version="1">MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASPIIGRVSDKVGRKPVLTVGLVLYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALASDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYKTPFWVAGALGLLSAIVLVILLPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVNEVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAHSKVAVMVATLVIFSAFDLLRPAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGMLLDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM15</accession>
    <name>F9UM15_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101158.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0793"/>
    <dbReference type="EnsemblBacteria" id="CCC78254">
        <property type="protein sequence ID" value="CCC78254"/>
        <property type="gene ID" value="lp_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0793"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.671"/>
    <dbReference type="eggNOG" id="ENOG5030I32">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081261_0_0_9"/>
    <dbReference type="OMA" id="TEFCATA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-690-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="243" mass="26666" checksum="7C5A2F68D031D6A8" modified="2011-10-19" version="1">MAARFTVGPTQIAIFPPSEVIPQTRAYYQAERFGLTRMARLSLGAPRLLHAGFIFDKYQFYYVIYQPLQGLTLTEFCATAKPLAKSTLGRQIGTMLTRLNTEVPAFGPTAAQSTEWDTLGPDFVAERTAWLQVHTVTPNQFVHGNLVGGNLIVTSGELGLQRFSAAHQAAKQTELVPLILQAFNDDTDLLAGFKETYQTDDLEKDLLLGLLLRVDGPQQIQALHPGAPVTLAAVQQVIAQRLS</sequence>
</entry>
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    <accession>F9UM98</accession>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641140.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888851.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1062810"/>
    <dbReference type="EnsemblBacteria" id="CCC78337">
        <property type="protein sequence ID" value="CCC78337"/>
        <property type="gene ID" value="lp_0895"/>
    </dbReference>
    <dbReference type="GeneID" id="57024578"/>
    <dbReference type="GeneID" id="66448841"/>
    <dbReference type="KEGG" id="lpl:lp_0895"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.758"/>
    <dbReference type="eggNOG" id="COG1309">
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    <dbReference type="HOGENOM" id="CLU_069356_17_2_9"/>
    <dbReference type="OMA" id="DAIENRQ"/>
    <dbReference type="PhylomeDB" id="F9UM98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-773-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="HTH_TetR"/>
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    <dbReference type="Pfam" id="PF00440">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF46689"/>
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            <end position="66"/>
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    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
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            <begin position="29"/>
            <end position="48"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="20895" checksum="8ECBE238B35062C5" modified="2011-10-19" version="1">MRKDAQINQQKILTAARQLFAARSIETVSMKDIATAAGIGPGTLYRHYAHKSTLCLALVTDRVATFIKTNQVYLTTTSVGAAARFDHVIGEYLAIREHNMALLMNVEAGEPGRRQFYQSELYQQLCDLLTQLVRDLKPTLSKPACEFQADMLIAMLKGTSYAFQRQWRGRSQSELLAQLHALMVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC3</accession>
    <name>F9UMC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein, MORN repeat family</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0924</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101208.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888876.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0924"/>
    <dbReference type="EnsemblBacteria" id="CCC78362">
        <property type="protein sequence ID" value="CCC78362"/>
        <property type="gene ID" value="lp_0924"/>
    </dbReference>
    <dbReference type="GeneID" id="57024603"/>
    <dbReference type="GeneID" id="66448862"/>
    <dbReference type="KEGG" id="lpl:lp_0924"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.782"/>
    <dbReference type="eggNOG" id="COG4642">
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    <dbReference type="HOGENOM" id="CLU_032017_6_0_9"/>
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    <dbReference type="PhylomeDB" id="F9UMC3"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
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    </dbReference>
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        <property type="entry name" value="MORN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP034300"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388033" evidence="1">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="13736" checksum="0DA8C57C14B48066" modified="2011-10-19" version="1">MGKISSRMVFEIITIIGIVTFAVISLTPSTAKQQSVQLDHGRMSYSGAVLKHKFDGQGTLQVNKQGRYVGNFTNGRFEGAGEFIAPNGWRLQGNFSKGALNGVVKLRVGNKTYAKKITGDGKLENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD4</accession>
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        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="12" type="primary">pepN</name>
        <name evidence="12" type="ordered locus">lp_0937</name>
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    <organism evidence="12 13">
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        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101213.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMD4"/>
    <dbReference type="STRING" id="220668.lp_0937"/>
    <dbReference type="MEROPS" id="M01.002"/>
    <dbReference type="EnsemblBacteria" id="CCC78373">
        <property type="protein sequence ID" value="CCC78373"/>
        <property type="gene ID" value="lp_0937"/>
    </dbReference>
    <dbReference type="GeneID" id="57024614"/>
    <dbReference type="KEGG" id="lpl:lp_0937"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.795"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_9"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="PhylomeDB" id="F9UMD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-809-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="9">
        <location>
            <begin position="217"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="10">
        <location>
            <begin position="509"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="844" mass="93949" checksum="BE7AB716D10404EF" modified="2011-10-19" version="1">MATTTHFYETFQPEHYNLYININRADKLISGKSTITGDAKAQEVLIHQNGLTIAGVQADGADVPFTVDNAIQGIRIELAKAGQTTLTITYSAKLTDTMMGIYPSYYEVNGVKKELIGTQFETTAARQAFPCVDEPEAKATFDLAIKYDEHDGETILSNMPEDHEADGVHYFETTVRMSTYLIAFAFGELQGKQTKTKSGVTIGVFGTKAHKANELDFALDIAKRSIEFYEDFYQTPYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPDNTALETKQRVATVIAHELAHQWFGDLVTMKWWDDLWLNESFANMMEYVATDALEPDWHIWETFQTSEASMALQRDATDGVQSVHVQVEDPAEIDSIFDGAIVYAKGARMLVMARALVGDDALRAGLKQYFINHKYGNAKGDDLWNALADASGMQVGDIMHSWLEQPGYPVVTAAVVDGQLTLSQQQFFIGKGEEVGRQWQIPLNSNYEAAPAIMKDQTVTVGDYAKLRDASGQPFRLNVGNNSHFIVKYDQTLLDDILAHVDDLTAIDQLQLLQDLRLLAEGRQISYAAVVPLLSRFAASHSTVVNAALYQVAGNLRKFVTPDSDEEKHLQTLFDQLSAAQVKRLGWLPQAGESNDDQLTRPYVLSAALYAKSSAAVLAAHELFEGNRDKLATLPADVRVFILRNEVKNFGSKDLFDSLLTASRQTADASYKADICDALTATTDPELIKQLVVKFEDADTIKPQDLRAWFRGVLANPAGEQAAWDWIRDEWSWLEATVGGDMEFTTYITVISRVFHTAERLAEFKAFFEPKINTPGLTREIKMDTKVIASRVALVEDERDAVNAAVAEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI4</accession>
    <name>F9UMI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, DUF3815 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641229.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888937.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0999"/>
    <dbReference type="EnsemblBacteria" id="CCC78423">
        <property type="protein sequence ID" value="CCC78423"/>
        <property type="gene ID" value="lp_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="57024663"/>
    <dbReference type="GeneID" id="66448917"/>
    <dbReference type="KEGG" id="lpl:lp_0999"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.846"/>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117642_3_0_9"/>
    <dbReference type="OMA" id="ACGWMVY"/>
    <dbReference type="PhylomeDB" id="F9UMI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-859-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16510" checksum="D3DC9E94CEB95737" modified="2011-10-19" version="1">MMGTIGQLVLAYIAVLGFGLIINIPHQALNVAGWIGTLTWGGYLIVQAFDGGVVLGSLIGSVGIGVLSSLAARYKKMPAIIFNIPSLVSFVPGSQAYQMVRNFALGNYREAVSFTLQVIMITGAIALGFLLAELLNRLIAFCIRQWRLHRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI9</accession>
    <name>F9UMI9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator, Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1004"/>
    <dbReference type="DNASU" id="1063604"/>
    <dbReference type="EnsemblBacteria" id="CCC78428">
        <property type="protein sequence ID" value="CCC78428"/>
        <property type="gene ID" value="lp_1004"/>
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    <dbReference type="GeneID" id="57024668"/>
    <dbReference type="KEGG" id="lpl:lp_1004"/>
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    <dbReference type="OMA" id="IDWRQVH"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="174" mass="19219" checksum="FF3291DA241915D8" modified="2011-10-19" version="1">MQLAKSFEQAACVLVLLATQQPEIPLTADVLHERIGGSASYIRKIIRKLVVAGLVTSTSGNNGGVHLARSPEDISITDVVAAIEGTLQTFPNYGYFDRVFKDVEPVAHEGTKVVNGIFSRADQLWLDFLDQQKLATLIKELLVVTQIPVLDWTNYSDDKMAQLNALLSRMRAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ2</accession>
    <name>F9UMZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889095.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1194"/>
    <dbReference type="EnsemblBacteria" id="CCC78581">
        <property type="protein sequence ID" value="CCC78581"/>
        <property type="gene ID" value="lp_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1194"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1012"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_17_3_9"/>
    <dbReference type="OMA" id="ITIVEYY"/>
    <dbReference type="PhylomeDB" id="F9UMZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1024-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13425" checksum="DE2EF9AE9A469BDA" modified="2011-10-19" version="1">MTASPSRKQIPIMSRKTTFEERIEIVEYVTKHKHSYAEAAEHFQVSYQQARSWVIKAQKNGYEALVDKRGHRKSAAELTEVDKLRLENRQLKSQLADKKLVEAFAKKLLELQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN19</accession>
    <name>F9UN19_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3H</name>
        <name evidence="2" type="ordered locus">lp_1225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643283.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1225"/>
    <dbReference type="EnsemblBacteria" id="CCC78608">
        <property type="protein sequence ID" value="CCC78608"/>
        <property type="gene ID" value="lp_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="57024848"/>
    <dbReference type="KEGG" id="lpl:lp_1225"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1038"/>
    <dbReference type="eggNOG" id="ENOG5030B0V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749620_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1049-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="369" mass="41555" checksum="A73A0BA32337E19D" modified="2011-10-19" version="1">MNHQQAYRVQRLILIIALMLILFGDTGMNAVFSFSHQPQSIWFYPQLVIALITAAGPNLLLMALGAYQLRRTALTVPQLIRRVLWIIGGITLFSLAFYLEDLVTQGSLNSFNIAGFLTALAQAPVGFYDILYELLGFFVTLPLLRVIAHHASVAIQQYLFWAELVFIGMVPILAYFTGLTTISVNSPLAITAGCFFALMGYWLSQTEVLHRITREHLLVAWLLTCGCYAVMVSVTMYQVNLEKNFDLISSQPFAQTFQAIPCLTLWVTIATWMMNRPRSKAVRRHNFVQTGYGDMLVAGLLITPFMVINRLLTPIIGAWWSGWLWSIAVLIVSVELVWLLRHVRWLQRLLPDLFGGSQLIGGSVNAQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN26</accession>
    <name>F9UN26_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Priming glycosyltransferase,undecaprenyl-phosphate beta-glucosephosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889129.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1233"/>
    <dbReference type="DNASU" id="1063038"/>
    <dbReference type="EnsemblBacteria" id="CCC78615">
        <property type="protein sequence ID" value="CCC78615"/>
        <property type="gene ID" value="lp_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1233"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1045"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_0_9"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="PhylomeDB" id="F9UN26"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1056-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="25954" checksum="29788B375E724831" modified="2011-10-19" version="1">MLLMELKEREIRPITIDAGRQHRRYGYRFIKRVFDFVASLLGLIILSPLFLLIAIAIKVEDPKGAVFYSQTRLGRGEVPFKMYKFRSMVSNADELLEKLLKDNEIDGAMFKMQDDPRVTKIGRFIRKYSIDELPQLLNVLQGSMSLVGPRPPLPREVEEYSDYDKQRLAVKPGCTGLWQATVRNSVGFDEMVKLDLTYISKRSVAFDVYILFKTVVIMFKPNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN55</accession>
    <name>F9UN55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppF</name>
        <name evidence="7" type="ordered locus">lp_1265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889158.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1265"/>
    <dbReference type="EnsemblBacteria" id="CCC78644">
        <property type="protein sequence ID" value="CCC78644"/>
        <property type="gene ID" value="lp_1265"/>
    </dbReference>
    <dbReference type="GeneID" id="66449141"/>
    <dbReference type="KEGG" id="lpl:lp_1265"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1075"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="PhylomeDB" id="F9UN55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1085-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="321" mass="36600" checksum="65496D118C67248E" modified="2011-10-19" version="1">MPDERKKILEVRHLKQYFNVGKKDEVRAVDDVSFDIYEGETFGLVGESGSGKTTTGRSIIHLYEPTDGEIIFDGKDVSKLHTKKERHEFRREIQMIFQDPYASLNPRMKVKDIVAEGIDIHGLAKDDADRTKQVEDLLETVGLNKDHSSRYPHEFSGGQRQRIGIARALAVEPKFIIADEPISALDVSIQAQVVNLMKELQVKQNLTYLFIAHDLSMVKYISDRIGVMHYGKILEIGPADEVYNHPLHKYTESLISAVPVPDPEFERNRKQVPYDETTEHDGKKRRMVEIAPGHFVRATEDEIPIYTKRAVDAGLITEFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF4</accession>
    <name>F9UNF4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts15C</name>
        <name evidence="11" type="ordered locus">lp_1400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889257.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1400"/>
    <dbReference type="EnsemblBacteria" id="CCC78743">
        <property type="protein sequence ID" value="CCC78743"/>
        <property type="gene ID" value="lp_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1400"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1174"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_0_9"/>
    <dbReference type="OMA" id="AGKYNIC"/>
    <dbReference type="PhylomeDB" id="F9UNF4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1204-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="451" mass="48925" checksum="09514F81012F36D7" modified="2011-10-19" version="1">MERFFNSKLMVGLQRAGQGLGNNKFITALQAAMMSLMGILMVGAIFQITMSVLGPTIFGVLSAKSILLAYLKIPFQFSMNSLSIWVVLFLGFHYAKNLKMTAPIMNAIDALFGFWIVAGGLIVSKTGTVSIDTTYLGAQGMFIGFVVVWISVRVEKLCTDKNIRINMPDAVPQFLQDGFASIVPLLFNAVIFLGASLLVTVGTAGKYNICSGFMELLAIPLSALTSTIGIFVLCILGALLWTFGIHGTMILVPIVMPLVIQAVSENAALQAAGKPVVFAPVMLFSFMTVAGGTGNTLPLALMAMRSKSKQLSAVGKLSIIPGWFKINEPMTFGIPIMYNPIMSIPFVLNIPVVMLCALVLYKIGFLTPGWIVITAILPMGFGSYLSTLSWRNALTDYLMLIPSALIWYPFFKVYEKQLIAKEAAVEAEEKRAAVSNQGNVPMQPVKPEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Transcription regulator, Cro/CI family</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101450.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889346.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1506"/>
    <dbReference type="EnsemblBacteria" id="CCC78832">
        <property type="protein sequence ID" value="CCC78832"/>
        <property type="gene ID" value="lp_1506"/>
    </dbReference>
    <dbReference type="GeneID" id="66449392"/>
    <dbReference type="KEGG" id="lpl:lp_1506"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1266"/>
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    <dbReference type="OMA" id="ICAYLEC"/>
    <dbReference type="PhylomeDB" id="F9UNP3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1293-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="68" mass="7452" checksum="E419DEFF04B06B11" modified="2011-10-19" version="1">MIRITLNVVMAQRNMTTSELAKRVGITPTNISILKTGKAKAIRFSTLEKICAVLDCQPGDIISYVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNP9</accession>
    <name>F9UNP9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication initiation and membrane attachment protein DnaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaB</name>
        <name evidence="3" type="ordered locus">lp_1512</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889352.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1512"/>
    <dbReference type="EnsemblBacteria" id="CCC78838">
        <property type="protein sequence ID" value="CCC78838"/>
        <property type="gene ID" value="lp_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1512"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1272"/>
    <dbReference type="eggNOG" id="COG3611">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040783_1_0_9"/>
    <dbReference type="OMA" id="KIASHWA"/>
    <dbReference type="PhylomeDB" id="F9UNP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1299-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="323"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="51868" checksum="78E5A917B17B920C" modified="2011-10-19" version="1">MPNDEPLTPKTGLVVPQAPALSAAQQAVLAELYLPLMGPLAYSLYAALRSLQSSENELSNRRSHAELLGILNVDLPTVLAARRKLEATGLLRSYYQQDELGAMYIYQLQAPLLALQFFADDLLSVLLLDTVGELRYQQLAGDFAAQPIDLTAAKDVTANILDVFHVDSQKVTTPPLSVQKVRAQLAANEPAEDHSPVLSDDDFDWQLLGQILKQNYVDLKQVASSRQLIITESRVYGISEIEMAKLISEVASLTTGQFDENQLKLLIARRYERPAVSSQQVATEATVATTTKDNKASAQLSTAEQQLVTYAKQTAPYDFLSALKQEKHGFVTSGENRLVHDLIGRGVLPNAVINMVIYYLLQNRELAALNRNLLETVANDWQQHGITTPEAALMYLKQRKQPRSTPTRRKNNRPTRKEIMPKWAQQQQQTESGKQPAQTGKQITAAQRKQLADRLAKLETNSEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU4</accession>
    <name>F9UNU4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, LytTr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640318.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889397.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1565"/>
    <dbReference type="EnsemblBacteria" id="CCC78883">
        <property type="protein sequence ID" value="CCC78883"/>
        <property type="gene ID" value="lp_1565"/>
    </dbReference>
    <dbReference type="GeneID" id="57025153"/>
    <dbReference type="KEGG" id="lpl:lp_1565"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1317"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_1_0_9"/>
    <dbReference type="OMA" id="VSRRYYQ"/>
    <dbReference type="PhylomeDB" id="F9UNU4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1344-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="16586" checksum="790615818D0F1131" modified="2011-10-19" version="1">MQVNIETEPDTSIPTVTLHVPVDYPETAALTAALKNLSIEAATLTVSQRGQLVQLPLTSILFIEATGHQVAAHTLDNVYRVPKSLTAVGTGLPAYFLRVSKSAIVNTKQVYSLTKTLTGNLIAFHHSPKQLYASRRYYRQLKISLEQKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV5</accession>
    <name>F9UNV5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640329.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889408.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1577"/>
    <dbReference type="EnsemblBacteria" id="CCC78894">
        <property type="protein sequence ID" value="CCC78894"/>
        <property type="gene ID" value="lp_1577"/>
    </dbReference>
    <dbReference type="GeneID" id="57025164"/>
    <dbReference type="GeneID" id="66449462"/>
    <dbReference type="KEGG" id="lpl:lp_1577"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1328"/>
    <dbReference type="eggNOG" id="ENOG5033E1E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199135_0_1_9"/>
    <dbReference type="OMA" id="SAMVKKT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1355-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021402">
        <property type="entry name" value="DUF3042"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11240">
        <property type="entry name" value="DUF3042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="58" mass="6443" checksum="78A5628596934051" modified="2011-10-19" version="1">MKSFTRGFLFGVVATAGAVIGSVLSFKKQVVDPIEDQENKFEENRKKAMRKSRSAHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW2</accession>
    <name>F9UNW2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase)</fullName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644309.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889415.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1585"/>
    <dbReference type="EnsemblBacteria" id="CCC78901">
        <property type="protein sequence ID" value="CCC78901"/>
        <property type="gene ID" value="lp_1585"/>
    </dbReference>
    <dbReference type="GeneID" id="57025171"/>
    <dbReference type="KEGG" id="lpl:lp_1585"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1335"/>
    <dbReference type="eggNOG" id="COG4508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105318_0_0_9"/>
    <dbReference type="OMA" id="CFKFWSV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1362-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016947">
        <property type="entry name" value="UCP030140"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030140">
        <property type="entry name" value="UCP030140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="21153" checksum="0CB4B86EB90BA5A7" modified="2011-10-19" version="1">MLELTTLLQQSIRLDRDITARQQIHWRPQERLQNAMVSLDVELAEMANTSEWFKVWKIHRGKADPDKTHRETLLNEYVDAMDFFFLVSAIQQWTHLIPVTPEQLTTIAAKPATDLNKQYLAIKHLLYDAYFNHRQESYQHAWHVFLKIGLVDFGFTQDEIQTAFTAKNHVNEQRQANNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY1</accession>
    <name>F9UNY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycine betaine/carnitine/choline ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">opuA</name>
        <name evidence="9" type="ordered locus">lp_1607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1607"/>
    <dbReference type="EnsemblBacteria" id="CCC78920">
        <property type="protein sequence ID" value="CCC78920"/>
        <property type="gene ID" value="lp_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1607"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1355"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_9"/>
    <dbReference type="OMA" id="MYEFNRA"/>
    <dbReference type="PhylomeDB" id="F9UNY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1382-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="44476" checksum="E454A2F3BBE99860" modified="2011-10-19" version="1">MFLTMEHLNKTYPGGKVAVEDFNLEIEKGEFVCFIGTSGSGKTTTMRMINRMLSQTSGTIKLNGKDISQIDPVKLRRQIGYVIQNIGLMPHMTIRDNITLVPRLLKWPQDKMNERAKKMIKLVELPEDYLDRYPSELSGGQQQRIGVVRALAADQDLVLMDEPFGALDPITRESLQDLVKDLQERLGKTFVFVTHDMDEALKLATRIVIMDGGDIMQVDTPDGILRHPANEFVENLIGKDRLIQARPSITTVGQVMLKDPIATTPGKSLTVALRQMHDKRVDSLLVTDEAGILKGVIGIEDVDYNFNSATSVGDIMKTDLFYVQSNSLIRDTVERILKRGLKNIPVVDEQHRLVGIVTRATLVDIVYDALWGDEDEDEAENNIHHGEDDAPAEGGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP32</accession>
    <name>F9UP32_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1668"/>
    <dbReference type="EnsemblBacteria" id="CCC78971">
        <property type="protein sequence ID" value="CCC78971"/>
        <property type="gene ID" value="lp_1668"/>
    </dbReference>
    <dbReference type="GeneID" id="57025242"/>
    <dbReference type="KEGG" id="lpl:lp_1668"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1407"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_9"/>
    <dbReference type="OMA" id="QMDVTDR"/>
    <dbReference type="PhylomeDB" id="F9UP32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1434-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="270" mass="29449" checksum="F7B24E8984F0892C" modified="2011-10-19" version="1">MAVILITGASSGIGFQTAKDLAQQGHVVYGAARRLNKLEALAPYGVKPLSLDITNEQSLSQAVATLIASEGRIDVLINNAGYGSYGAVEDVSIDEARQQFEVNLFGMARLTQLVLPYMRAQREGRIINTSSMGGRLVSYMGAWYHATKYAVEAFSDALRMETKDFGIKVAIIEPGGIKTNWGFIAADHLEASARHSAYQTQATKAAAGMRRQYSSRMMSDPKIISKAISKAVNQKRPRVRYLIGFGAKPLVLAKAILPTRVFDFIMMHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP47</accession>
    <name>F9UP47_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF554 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640421.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78986">
        <property type="protein sequence ID" value="CCC78986"/>
        <property type="gene ID" value="lp_1684"/>
    </dbReference>
    <dbReference type="GeneID" id="57025257"/>
    <dbReference type="KEGG" id="lpl:lp_1684"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1422"/>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_2_0_9"/>
    <dbReference type="OMA" id="TEGMNGD"/>
    <dbReference type="PhylomeDB" id="F9UP47"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1449-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="25681" checksum="14FDD35FBD6ADAC7" modified="2011-10-19" version="1">MPIGIITNVCAIFFGGIVGALTGKRMSQRLKDGLNMSFGICSMCMGIYAIAPLKNLAAVIFAVIIGTGIGLLCHLGTAINHGAAAMQRFISRFVKAPATFEKQAFEQTMVTVIVLFCASGTGIYGTLTEGMNGDATILISKSILDFFAAVIFGANLGLVVSLIAVPQLIILTALFLIAHLVFPLTTPDMILDFKAVGGILMVASGFRIIAVKMFPTADMIPMMVVIMPISWLWMNFVLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP63</accession>
    <name>F9UP63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, TspO/MBR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101517.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1700"/>
    <dbReference type="DNASU" id="1062224"/>
    <dbReference type="EnsemblBacteria" id="CCC79002">
        <property type="protein sequence ID" value="CCC79002"/>
        <property type="gene ID" value="lp_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1700"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1436"/>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_2_0_9"/>
    <dbReference type="OMA" id="GLNLIWM"/>
    <dbReference type="PhylomeDB" id="F9UP63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1465-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18274" checksum="6A0AA3AC1AD547D4" modified="2011-10-19" version="1">MIKERPKFNWLHLLIFIVVVEAIGSLSAWLAGDIKAVYNGLNLPVLSPPDGLFGIVWPILYALIAIAGYLVFQQATTHRDRLMDATLFGIQLLLNFIWSIIFFSQSAYWWGLVIIIVLDLVVLLCILRFYRSSRLAAILMVPYLVWICFATYLTLGVALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP93</accession>
    <name>F9UP93_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1738"/>
    <dbReference type="EnsemblBacteria" id="CCC79032">
        <property type="protein sequence ID" value="CCC79032"/>
        <property type="gene ID" value="lp_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1738"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1466"/>
    <dbReference type="eggNOG" id="COG5353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114070_1_1_9"/>
    <dbReference type="OMA" id="NANKHHK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1495-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041401">
        <property type="entry name" value="DUF5590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17881">
        <property type="entry name" value="DUF5590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="SSF54403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5590" evidence="2">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18805" checksum="732F34B3BDA60C7F" modified="2011-10-19" version="1">MRVQRRRRPERLIMIILVVILAIIVAVYGTLWAAQRPMHQAQKTAYSLAVSKGKLKTTTAFSQYNGTSSYYVVTGTSSKNVPVYALINANKHHKTTVIKQFAGISRTKALKKVWSKRNPSKVIKATLGKYDGTVVWEITYLNQKKNLCYEILQYSNGNQLKSIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB0</accession>
    <name>F9UPB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640488.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889563.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1757"/>
    <dbReference type="EnsemblBacteria" id="CCC79049">
        <property type="protein sequence ID" value="CCC79049"/>
        <property type="gene ID" value="lp_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1757"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1482"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_4_3_9"/>
    <dbReference type="OMA" id="DHYVTHF"/>
    <dbReference type="PhylomeDB" id="F9UPB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1513-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="11102" checksum="C88534042314BAA3" modified="2011-10-19" version="1">MANEIPRSEVDSQQLLVFKVLADVVRLNIVKYLKLQDQAVTCGQVGQAMGISKTAGSYHFKLLEKAGLITVKKVAREKYVMLNPKTFDHYVTHFYQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC2</accession>
    <name>F9UPC2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889575.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79061">
        <property type="protein sequence ID" value="CCC79061"/>
        <property type="gene ID" value="lp_1773"/>
    </dbReference>
    <dbReference type="GeneID" id="66449622"/>
    <dbReference type="KEGG" id="lpl:lp_1773"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1495"/>
    <dbReference type="eggNOG" id="ENOG5032EV9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942644_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1524-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="359" mass="41343" checksum="D836977EADBD3E50" modified="2011-10-19" version="1">MLVIVWILLVLLLGLMGWLEYHNLQHPVIQPAKTLAPRAQLQLQHQVRQHVTDQAPRLKWLYYGMAACWWLGVISLLVSCYLVSAKLTLLIFPIRSVVTSIALMIVGIILLMIPALVWPTQSYDYLIGHSTQDHHWQLADTATFEHYRRFQIWLVLALDVFILIGWISWAYRVSTVPMVTIEYLLMVVAIAVPVVALITLLAQLPYLHQNRYLIPVSGRFGTQHYHANQALMQQQPDLKSRLIIVNVVRIIGYALGLYALWLLYANILAPAFTVDTSIVYPAAAFAIIGLLIVLTAGGVWLPRFYDYLQLLDNKTLTFKLAGSDRFRRFRFHLYYFKLAFSILWIVIWALIIGYIYYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL9</accession>
    <name>F9UPL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644440.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1891"/>
    <dbReference type="DNASU" id="1061307"/>
    <dbReference type="EnsemblBacteria" id="CCC79158">
        <property type="protein sequence ID" value="CCC79158"/>
        <property type="gene ID" value="lp_1891"/>
    </dbReference>
    <dbReference type="GeneID" id="57025484"/>
    <dbReference type="KEGG" id="lpl:lp_1891"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1594"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151843_0_0_9"/>
    <dbReference type="OMA" id="KLINKWR"/>
    <dbReference type="PhylomeDB" id="F9UPL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1620-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="14791" checksum="DA76E5F0CE692E2D" modified="2011-10-19" version="1">MLVKYRKDYEKVAMGLLSFIPDFKDLIHLQTEMQWYQSTEDHQLLLWRQGDGDFCGIIGIEVGSDFILLHHDSLSPEERTAANQYQMLDELAALYPKQRVMGTLEMAPIIGAWERNRDKQPTTTNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN2</accession>
    <name>F9UPN2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">drrB</name>
        <name evidence="8" type="ordered locus">lp_1909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640613.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889685.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1909"/>
    <dbReference type="DNASU" id="1061647"/>
    <dbReference type="EnsemblBacteria" id="CCC79171">
        <property type="protein sequence ID" value="CCC79171"/>
        <property type="gene ID" value="lp_1909"/>
    </dbReference>
    <dbReference type="GeneID" id="57025497"/>
    <dbReference type="KEGG" id="lpl:lp_1909"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1608"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_9"/>
    <dbReference type="OMA" id="VMITMYT"/>
    <dbReference type="PhylomeDB" id="F9UPN2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1633-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="27914" checksum="C53C3C2861E578AB" modified="2011-10-19" version="1">MEIKQPAELSHVLTMTHRNLLKMWHNPDNVSDVVIQPIIFTLLFGYLFGGAIAGSVQAYLPMLVTGILIQSILNAASGSGQQLREDINAGVFDRFKTLPISPIVPLAGQLVGDVFRLLISGLMALVTAFMMGWRPIVSPLVLIGVLLLAVFVGWSLSWVFALVGLMVKNAALIGSLSMIIILVLTFLSNAFIPTKTLPHLLQTIVRLNPVSLTITAMRTILRTGHWGPDAFGVLLSGFLIIVIFMPLTVLAYRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP4</accession>
    <name>F9UPP4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640626.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889697.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1922"/>
    <dbReference type="DNASU" id="1062064"/>
    <dbReference type="EnsemblBacteria" id="CCC79183">
        <property type="protein sequence ID" value="CCC79183"/>
        <property type="gene ID" value="lp_1922"/>
    </dbReference>
    <dbReference type="GeneID" id="57025509"/>
    <dbReference type="KEGG" id="lpl:lp_1922"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1620"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_29_2_9"/>
    <dbReference type="OMA" id="QMAVIDF"/>
    <dbReference type="PhylomeDB" id="F9UPP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1645-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="16901" checksum="470C76FF9F8351E1" modified="2011-10-19" version="1">MQDSLGIMIKKANNALARDSDHYAKSLGLTGMQISTINFIANNEQHHDLFQRDLELEFNIRKATCSSLVSKMEAADLLIRVPAKDDGRYKRLLLTPKARQLATKIERFFETSEQRMATILGVNTAETYEALRQIAVAFSTPTHAPENWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP8</accession>
    <name>F9UPP8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mutT</name>
        <name evidence="2" type="ordered locus">lp_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889701.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1927"/>
    <dbReference type="DNASU" id="1061660"/>
    <dbReference type="EnsemblBacteria" id="CCC79187">
        <property type="protein sequence ID" value="CCC79187"/>
        <property type="gene ID" value="lp_1927"/>
    </dbReference>
    <dbReference type="GeneID" id="57025513"/>
    <dbReference type="KEGG" id="lpl:lp_1927"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1624"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082381_1_0_9"/>
    <dbReference type="OMA" id="TLPGGWC"/>
    <dbReference type="PhylomeDB" id="F9UPP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1649-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="201" mass="22280" checksum="6027291C1034AF4C" modified="2011-10-19" version="1">MPSSLLTTQRAMLALIQSGLAYTTDPFDKDRYQKLQTLLIQQMAAAANVATADLTAALTQDSGYITPKIDVRGLIRHGNQLLLVQDIKTKLWALPGGFADVGYTPTENVQREVWEETGRHVAVQGLITVFDTALRVDIPQPFQYYKLVFACEITDGQFEPNIEVAQTAYFTLDNLPPLSQNRTTEEQLAQLMASSTTITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS0</accession>
    <name>F9UPS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640664.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="lp_1953"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|220668.9.peg.1649"/>
    <dbReference type="HOGENOM" id="CLU_123192_1_2_9"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1673-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016787">
        <property type="entry name" value="UCP021328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11208">
        <property type="entry name" value="DUF2992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021328">
        <property type="entry name" value="UCP021328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="16615" checksum="511111288940CAF7" modified="2011-10-19" version="1">MINRCKLTVFFDQQFYQGVFERWSTDGYQVARVTFGTQNPSEPQIRLLIQDRWSTLQWTTASAVAQQQLVREYRRAARQCRQHHVRFKPTRAMQMLKLEHQRNLVMKKRQQRRARHDHAQLIRAKRLAKHRAQHRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPV6</accession>
    <name>F9UPV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640702.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1994"/>
    <dbReference type="EnsemblBacteria" id="CCC79245">
        <property type="protein sequence ID" value="CCC79245"/>
        <property type="gene ID" value="lp_1994"/>
    </dbReference>
    <dbReference type="GeneID" id="57025570"/>
    <dbReference type="KEGG" id="lpl:lp_1994"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1685"/>
    <dbReference type="eggNOG" id="ENOG5030A1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2356212_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1709-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="96" mass="10996" checksum="65AE3FCF9A0AB6C7" modified="2011-10-19" version="1">MILIERIYRRGHEQLTTVDQIEKFQTNDGYVTSNEVLAREIGADSENCFYKNQEGKRKKVVATKDDQGTWHLKTIGTTDPTSDGLLQLPHMDDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW5</accession>
    <name>F9UPW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ISP2_3</name>
        <name evidence="9" type="ordered locus">lp_2006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101624.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2006"/>
    <dbReference type="EnsemblBacteria" id="CCC79254">
        <property type="protein sequence ID" value="CCC79254"/>
        <property type="gene ID" value="lp_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2006"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1695"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="OMA" id="RMGRETK"/>
    <dbReference type="PhylomeDB" id="F9UPW5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1718-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="DUF772" evidence="8">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="7">
        <location>
            <begin position="257"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="550" mass="64274" checksum="B7E4BAD5C8620B23" modified="2011-10-19" version="1">MQDYYNMNQTTLSIALDYQPEEHHSARYINQLVESLKLKYVYQFGRPREYNLGTMLKLVLLAYSYGIFSSRKIERFARENKPAGWLIADQIPSYRTICRFRISDELATLTTDSLSQLTQYLRQNGMIDDVSFIDGTKILADANKYSFVWKKNTIRFDKMNREKLVDLLGELHEAKIVGEIPAGSELTPELLDIMISKVEDHLVVLNETVEATKQVSPNPAKQQRRTVKSQKRKLDKRRDKMREHQAQQAIYGQRNSYSKTDYDATFMRVKEDPMQNGQLKPAYNVQIATSNQFITGYRLFPNPTDTRTLQSFIEHLKANNVLGHTIVADAGYGSESNYRYLEDEFGQHTVLIPYGTMLKENSRKWQSDDRKVMNWDYHEKDDYFINPQNVRFNFNAYRQRTDKYGFTRDFKEYIAEKYDENHQLISAALTPKGYLKRISVNENWEYFKSKQRELLSSPETGQIYAQRKIDVEPVFGKMKASLHFNRFSVRGFDKVTKEAGIVILALNIMKLVTVGTNFKNQRRKRMGRETKIRFLVPFAYTEASYVTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPZ3</accession>
    <name>F9UPZ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatic amino acid biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644492.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2036"/>
    <dbReference type="DNASU" id="1062268"/>
    <dbReference type="EnsemblBacteria" id="CCC79282">
        <property type="protein sequence ID" value="CCC79282"/>
        <property type="gene ID" value="lp_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2036"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1721"/>
    <dbReference type="eggNOG" id="ENOG5032W87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530647_0_0_9"/>
    <dbReference type="OMA" id="LDNAWGP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1743-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="175" mass="19612" checksum="9F7B5CBD2C23308E" modified="2011-10-19" version="1">MQIHTLGPTATDSYAAAQVYNHRNWQDQAVIVEHPSFEAILTDLTAYSGDQLVIPAAFKSDTLNASWGDIHYALLSQLTLTSCFMTQLDPLVVLQRVNADNQIGYTHAATAQLLTRVVHQVVVQTVASKYLAYQAYQRNQAAYVLTNEKNVTLTTHERELARLTPSMVWCVYQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ76</accession>
    <name>F9UQ76_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lon</name>
        <name evidence="4" type="ordered locus">lp_2132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640808.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889879.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2132"/>
    <dbReference type="MEROPS" id="S16.012"/>
    <dbReference type="DNASU" id="1063826"/>
    <dbReference type="EnsemblBacteria" id="CCC79365">
        <property type="protein sequence ID" value="CCC79365"/>
        <property type="gene ID" value="lp_2132"/>
    </dbReference>
    <dbReference type="GeneID" id="57025671"/>
    <dbReference type="KEGG" id="lpl:lp_2132"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1806"/>
    <dbReference type="eggNOG" id="COG3480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042037_2_0_9"/>
    <dbReference type="OMA" id="TDHTFPF"/>
    <dbReference type="PhylomeDB" id="F9UQ76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1826-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="3">
        <location>
            <begin position="231"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="348" mass="38545" checksum="36BAF467EE944F0B" modified="2011-10-19" version="1">MTKGRELLKRYWGLLVVILVVLALFLIPLPYYIEGPGSANNLKTFVTVKRHPDHHRGKFMLTSVAEARATPLMWLYAQLNPHYDVVSAQDMTGGQDDATYNRVQKFYMRSAINEAIATAYSAAHQQYRKVYQGIYVLTVQSNSKFRNQLKVGDTITKVDGHHFNTASAYQHYIGKQGVGHRVTITYRRKGHLKQASAPLIKLSTHRAGIGIGLTDNIKVTTTIPVKVDPGQIGGPSAGLMFSLQIYQQLTNQNLRHGRKIAGTGTIDQNGQVGEIGGIDKKVIAAKRAGATIFFAPYVKPTKALLAVEEKGQTNYQLAKATAKKYAPNMKVVPVTSFKQAVHYLQTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA7</accession>
    <name>F9UQA7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640838.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889910.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2174"/>
    <dbReference type="EnsemblBacteria" id="CCC79396">
        <property type="protein sequence ID" value="CCC79396"/>
        <property type="gene ID" value="lp_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2174"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1837"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQA7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1857-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394399" evidence="2">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="168"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="37568" checksum="1793252158D104E4" modified="2011-10-19" version="1">MRWKQIGQWWLLVLALLLGGLLGSLPGQAASNTPASGFILTPLLPKDQLDKQAGYFNMKVTPGTTSTFRVSVSNPGKSAITLQVTPVNATTSDAGSVAYVPSKRHDPSATTTFTDMTSSGVVVKLAAHQAKTVAFKTTIPKSGFQGEVLGGLFVTNPTANAARPTTSQGFMLKNRYAEVTAVALWCQPQVTIPVKLVLDEVKVTPTNGQPVLFAKLRNLTPTLFGQLKIQARVIQRTTGKTVATQQLKSGSMAPNSWFNYQVALGTQNLAAGKYRLKLHLTSGQRVWDFTRDFTLTAERAQQHNHHLVGPRQVNWWLWGAVALVILLALLMAAYWFGQRRSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQE4</accession>
    <name>F9UQE4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">cutC</name>
        <name evidence="3" type="ordered locus">lp_2220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2436"/>
    <dbReference type="EnsemblBacteria" id="CCC79615">
        <property type="protein sequence ID" value="CCC79615"/>
        <property type="gene ID" value="lp_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2436"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2059"/>
    <dbReference type="eggNOG" id="ENOG5030B7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2369312_0_0_9"/>
    <dbReference type="OMA" id="DLTQCWG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2101-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="10818" checksum="C3C465CE6F6D365B" modified="2011-10-19" version="1">MNWGNQLVNLAANHAYEPAALHWTKQRMKRHLKAGGSAQDEVCAHEYKLFALEVLIIEYQRDGLNFDLTQCWGKPAEYFIDLEQARQGLQTGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY2</accession>
    <name>F9UQY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2443"/>
    <dbReference type="EnsemblBacteria" id="CCC79621">
        <property type="protein sequence ID" value="CCC79621"/>
        <property type="gene ID" value="lp_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2443"/>
    <dbReference type="eggNOG" id="COG3422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803736_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1508" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="143" mass="16335" checksum="18F68C070FD3C474" modified="2011-10-19" version="1">MKLLSVLAARVLPILEQLFSYSNLAFSDTLRTSNSFGLLKCVKNIIQFFNRDLLVKHISNPECKFHCIFASSRPLRYTCYKGVIMMYFSIKKASNGQYYFVIRSSNNEIVATSETYLTKYSAEKTIESIKNDISPSSIVIDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR38</accession>
    <name>F9UR38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Drug/metabolite transport protein, EamA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101810.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890191.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2509"/>
    <dbReference type="EnsemblBacteria" id="CCC79677">
        <property type="protein sequence ID" value="CCC79677"/>
        <property type="gene ID" value="lp_2509"/>
    </dbReference>
    <dbReference type="GeneID" id="57025941"/>
    <dbReference type="GeneID" id="66450228"/>
    <dbReference type="KEGG" id="lpl:lp_2509"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2114"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_9"/>
    <dbReference type="OMA" id="PFQIMAN"/>
    <dbReference type="PhylomeDB" id="F9UR38"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2169-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="34265" checksum="ADFFFD5EE792A04C" modified="2011-10-19" version="1">MTQQNHLRGVLLASSACILWGISGVAASTLFINNPHLTAMWLTQVRMISAGLILLVWGMVAGKHPFKIWHHRHAAWTAVSYGLLGLIPVQLCYFEAVRVGNAPIATIIQFLGPFIISIYYFLFKHVTPSRIELIGMIMAFIGTLLIVTHGHLNSLAISPVILFWGGLSAIGVATNTLIPRTILPKYGALTVTGWGLLIAGLFLTLLQPMWRVHLTITWPQLGLLIVIILLGTVAPFLMFARSLSDILPTTASLMDAFEPLAATVFSITFLNVQLTSFDFIGGLLIILAVMALSLNTHKMLHFLRRRRAHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR98</accession>
    <name>F9UR98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate:nucleotide phosphotransferase,PPK2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642687.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2589"/>
    <dbReference type="EnsemblBacteria" id="CCC79737">
        <property type="protein sequence ID" value="CCC79737"/>
        <property type="gene ID" value="lp_2589"/>
    </dbReference>
    <dbReference type="GeneID" id="57025998"/>
    <dbReference type="GeneID" id="66450287"/>
    <dbReference type="KEGG" id="lpl:lp_2589"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2173"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_9"/>
    <dbReference type="OMA" id="RTHYENV"/>
    <dbReference type="PhylomeDB" id="F9UR98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2228-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="34525" checksum="45C670951E5505F3" modified="2011-10-19" version="1">MNFEKHYRYTGKQKLGLTKLATAVDPEFEDEKVIKAQIAKNIKQLTELQGKLYAQDRFGVLVIFQAMDAAGKDSMIRHIMSGVNPQGCEVTSFKQPTTKEIAHDYLWRIHDRVPKRGMIGIFNRSYYEDVLVSRVHPEIIVNEHVGEINDKKQVDDAFFERRFNDLRYFEDYLQHNGYLVLKFFLHMSKAEQKQRFIRRIEIPSHNWKFSAADIQERQYWDDYQRAYDDAITKTATKATPWYVIPSDSKWYSRLCVSEIINQRLSELPLAYPSLDASAQAQLKTALEQLDRETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URC8</accession>
    <name>F9URC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate oxidase</fullName>
            <ecNumber evidence="6">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pox3</name>
        <name evidence="6" type="ordered locus">lp_2629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101858.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890281.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2629"/>
    <dbReference type="EnsemblBacteria" id="CCC79767">
        <property type="protein sequence ID" value="CCC79767"/>
        <property type="gene ID" value="lp_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2629"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2206"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9URC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2258-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014092">
        <property type="entry name" value="Pyruvate_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02720">
        <property type="entry name" value="pyruv_oxi_spxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="196"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="386"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="585" mass="64259" checksum="FD161A000E861993" modified="2011-10-19" version="1">MAKMIEASVAMLKVIEAWDVKQIYGYAGGSFNSTMHALDVEQERLQYVQVRHEQVGALAAAADAKLTGKIGVAFGSAGPGAVNLLNGLYDAKEDHVPVLALVGQVAHTNMNYDYFQEFAEEPIFSDVAVFNRTVMTPESLPYVVDKAIRTAYRENGVAVVTIPNDFGYVEIPDLNYDSASVPAKLTGIPTIDDEQVKTVLTMIKNAKYPVFHVGQGTRGATEDMMALAERLQVPIIITGLAKGVIPDSFDGNMGSAYRAASKAADELMGITDLVVSVGADYSFAQIMYTTHDFKYVQIELDPGKFGRHHHLDFGVNGDAKVFIKRALALSEPASPSPYYQAAKADMADWKQYLKKLSERTTDPLEYEQVYQEINRVAADDAVFSMDVGDNTINSFRFLKMNPKQKLLTSALFATMGAGVPGAIAAKMSYPDRQAFNIAGDGAFSMVMQDLLTEVKYHLPIFNIVTSNQTLNFIKSEQEDVPQPYYGIDLIDADFAKIAEGMGVKGIRVEHFDQLHAAFETAMTELKAGRPVLIDAKITDKRGLPVEILDVDPTKTSDASVSAFKEKYDANELKPLTSYFKEFNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE4</accession>
    <name>F9URE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101868.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2651"/>
    <dbReference type="EnsemblBacteria" id="CCC79783">
        <property type="protein sequence ID" value="CCC79783"/>
        <property type="gene ID" value="lp_2651"/>
    </dbReference>
    <dbReference type="GeneID" id="57026043"/>
    <dbReference type="KEGG" id="lpl:lp_2651"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2221"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_2_1_9"/>
    <dbReference type="OMA" id="FRGDYIK"/>
    <dbReference type="PhylomeDB" id="F9URE4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2274-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="237" mass="27639" checksum="2F310663C2991A38" modified="2011-10-19" version="1">MASSKIVPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGIHYLDVRKAIENMNAVPEIRLEAFKLIVDGSESDVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIFNSEIVNNDLMPFLVKKYGLKASFFSHTQPALITKSNRKEFDLNVGDPMIYMQTRGIEEKEIIYYRKAAVVGNLIMYIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE7</accession>
    <name>F9URE7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642643.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890300.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2654"/>
    <dbReference type="EnsemblBacteria" id="CCC79786">
        <property type="protein sequence ID" value="CCC79786"/>
        <property type="gene ID" value="lp_2654"/>
    </dbReference>
    <dbReference type="GeneID" id="57026046"/>
    <dbReference type="KEGG" id="lpl:lp_2654"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2224"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_5_9"/>
    <dbReference type="OMA" id="YSFISRI"/>
    <dbReference type="PhylomeDB" id="F9URE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2277-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11990" checksum="1D2F12A40D53B522" modified="2011-10-19" version="1">MLTEIGKIIRQRRQQHGITIEQLAEQSNVSISLISRLERGKVDNIKLQSLTAIAETLNLKIADFFRDELLQSPNVVALLDYLSDLPAHQREELAGTLLKLLRLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF1</accession>
    <name>F9URF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890304.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2661"/>
    <dbReference type="EnsemblBacteria" id="CCC79790">
        <property type="protein sequence ID" value="CCC79790"/>
        <property type="gene ID" value="lp_2661"/>
    </dbReference>
    <dbReference type="GeneID" id="57026051"/>
    <dbReference type="GeneID" id="66450328"/>
    <dbReference type="KEGG" id="lpl:lp_2661"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2229"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_0_9"/>
    <dbReference type="OMA" id="FMIETGY"/>
    <dbReference type="PhylomeDB" id="F9URF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2281-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="27376" checksum="09C8E8397813B20E" modified="2011-10-19" version="1">MADLVYQQVINDLNKRIMANEFVDKKLPDERSLSEQYQVSRSSIKRALNVLANKGLIFKKRGSGTFINPLYLKNQSSFKYEGTNLGITDSLNTEGAKPSIQLLDFRVIPASQELQQDLFLTADEFVYEIKRLRLLDDQPFMIESGYIPIKLVPQLNRQVVSGSIFNYVQKTLHAAVTKSFLSIAADASNTTDQELLHLQPNEPVGLMSGIFFLDDGTPFEVSNMRLHYQYMKYTTFVSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN2</accession>
    <name>F9URN2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890385.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2761"/>
    <dbReference type="EnsemblBacteria" id="CCC79871">
        <property type="protein sequence ID" value="CCC79871"/>
        <property type="gene ID" value="lp_2761"/>
    </dbReference>
    <dbReference type="GeneID" id="57026132"/>
    <dbReference type="KEGG" id="lpl:lp_2761"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2311"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_9"/>
    <dbReference type="OMA" id="PNFRCEF"/>
    <dbReference type="PhylomeDB" id="F9URN2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2362-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="21269" checksum="ED4C91697B56585E" modified="2011-10-19" version="1">MNLDEKFAYMATGQPYRDTDAELTALRDQATLTTNAVNATADPETKETLLRQLVGSAGRKPFVNPNFRVEFGRNIHLGDNFYANYDCVMLDGAPITIGSQVLLGPKVGLYTSNHLFDATERIRGGCIARPITIGDGCWLAANVTVLPGVTIGANTIIGGGSVVTHDIPANVIAAGNPCQVIRPITAADRTGYTGAQFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP8</accession>
    <name>F9URP8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PTS system, cellobiose-specific EIIA component</fullName>
            <ecNumber evidence="7">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pts20A</name>
        <name evidence="7" type="ordered locus">lp_2780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890401.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2780"/>
    <dbReference type="EnsemblBacteria" id="CCC79887">
        <property type="protein sequence ID" value="CCC79887"/>
        <property type="gene ID" value="lp_2780"/>
    </dbReference>
    <dbReference type="GeneID" id="49394888"/>
    <dbReference type="GeneID" id="57026148"/>
    <dbReference type="KEGG" id="lpl:lp_2780"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2327"/>
    <dbReference type="eggNOG" id="COG1447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152490_1_0_9"/>
    <dbReference type="OMA" id="MEQSRMA"/>
    <dbReference type="PhylomeDB" id="F9URP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2378-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00215">
        <property type="entry name" value="PTS_IIA_lac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="12474" checksum="15FAC6E194742108" modified="2011-10-19" version="1">MAEEQTKEVEASLETIMGLIVNGGNAKSSAFEAIKAAKEGDFETADAKLKEADNFLTEAHNSQTSMLTAEAQGEHTHVSLLLVHSQDHIMNAITFRDLAGEVVDVYRRLAADEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ2</accession>
    <name>F9URQ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgm7</name>
        <name evidence="1" type="ordered locus">lp_2785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890405.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2785"/>
    <dbReference type="EnsemblBacteria" id="CCC79891">
        <property type="protein sequence ID" value="CCC79891"/>
        <property type="gene ID" value="lp_2785"/>
    </dbReference>
    <dbReference type="GeneID" id="57026152"/>
    <dbReference type="KEGG" id="lpl:lp_2785"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2331"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="PhylomeDB" id="F9URQ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2382-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="224" mass="25414" checksum="FEA15B8EEFC142CA" modified="2011-10-19" version="1">MATIHLYLVRHGQTKLNAAGRLQGIYDSELTHTGVRSAQRLARMLADVHFDAAYVSDLGRAQQTSRIITALHPEIKKPTIDVGLREFNFGGLEGTRNMWIVKQVQKQLGIGTFVKLMLSRERFATLLWVFNSLDQTRGAETLVGVTDRISSALRRICLYESQDSQHDKNILIVSHGLVLSAFLYQISPRELPTRLLKNTSVSRVDYQNRQFKLIDINITPKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW5</accession>
    <name>F9URW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2864"/>
    <dbReference type="EnsemblBacteria" id="CCC79954">
        <property type="protein sequence ID" value="CCC79954"/>
        <property type="gene ID" value="lp_2864"/>
    </dbReference>
    <dbReference type="GeneID" id="66450494"/>
    <dbReference type="KEGG" id="lpl:lp_2864"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2397"/>
    <dbReference type="eggNOG" id="ENOG50309VP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1693274_0_0_9"/>
    <dbReference type="OMA" id="LIISWFY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2451-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="18167" checksum="C50E71C1741D2D63" modified="2011-10-19" version="1">MWKTSHLLISWFYGAIAVFIIMFFTARQEVNRIVLEFNPFVIYSIICALVLFPIVKYRWPRVFQVWRKQPKETPSTRPDDEQIIQDSGRPWSVAAKRTKPKPVPTALTPQVEAKSDFMDGFINFFKNILMAVILVPLSPIICGYFGVQDWRQRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9US00</accession>
    <name>F9US00_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644778.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890503.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2912"/>
    <dbReference type="EnsemblBacteria" id="CCC79989">
        <property type="protein sequence ID" value="CCC79989"/>
        <property type="gene ID" value="lp_2912"/>
    </dbReference>
    <dbReference type="GeneID" id="57026262"/>
    <dbReference type="GeneID" id="66450525"/>
    <dbReference type="KEGG" id="lpl:lp_2912"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2431"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="PhylomeDB" id="F9US00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2485-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="540" mass="60219" checksum="8445607C196E3A68" modified="2011-10-19" version="1">MLTVNNVSMQFSTRKLYEDVNLKFTPGNCYGVIGANGAGKSTFLKILEGKLQPTTGTVSMGPNERMSSLNQNHFAFEDEEVLATVIRGHEKLYEIMTEKDALYAKPDFSDEDGIRAAELEGEFAEMDGWNAESEADQLLQNLGIDESMQHLKMSELTEPQKVKVLLGQALFGSPDVLLLDEPTNGLDVQSISWLEDFLAGYEKTVIVVSHDRHFLNQVCTHMCDVDFGKITLFVGNYDFWMESSQLAAKLQANANAKKADQIKELQEFVARFSANASKSKQATSRKKQLEKITLDDIKPSSRKYPFIKFTPDREIGNDLVKVENVSKSIEGVKILDNISFTLRPNEKTALISRNDLATTTLMQIIAGSMAPDSGTVTWGQTTSRTYLPKDINEEYAGSELPIIDWLRQFASKEESDNTFLRGFLGKMLFSGSDVERPVNVLSGGEKVRGMLSKMMLSRANVLLLDDPTNHLDLESITALNDSLIDFKGAIVFTSHDHEFIQTIADHIVEVSAKGVVDRGDTTYDEYLAHEATQGRVQDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9US03</accession>
    <name>F9US03_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA3</name>
        <name evidence="15" type="ordered locus">lp_2915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2915"/>
    <dbReference type="EnsemblBacteria" id="CCC79992">
        <property type="protein sequence ID" value="CCC79992"/>
        <property type="gene ID" value="lp_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2915"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2434"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_9"/>
    <dbReference type="OMA" id="LMWDLMK"/>
    <dbReference type="PhylomeDB" id="F9US03"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2488-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="5"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="496"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="534"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="835" mass="89581" checksum="FDFACD7EFC6DB141" modified="2011-10-19" version="1">MPQTTLPTHIQVRGAHVNNLKNIDIDIPLNEFVAITGRSGSGKSSLAMGVLYAEGARRYLNALSTFTRRRINQVGKASVDSVQYLPSALALRQRPQVPGVRSTVGTMSESLNILRLAFSRLSSAVCPNGHRMPPTLDVAENDGYVTCPTCGAKFRAPGAEDFAFNSGGACPTCGGLGQVRQIDPALIIADENQTIEEGAVASWHLPGRNFMPIVAREIGIPIDIPYKDLSEADKTRVLHGPKQTVAINIPSAKGKIFHMDNAVYENAFAAVEDSMATTKNERAINRLNRFYKFDTCPDCHGSRFNPQLFNYELNGQNIATVSDMTVAALHDFATTIVPWLPTKMHHLGQSLVDELLLSLQPMEELGLDYLTLSRPGATLSTGELQRIQLGRTLRSATTGVLYVLDEPSVGLHPANVAGLIKAFRGLVAQGNSVVVVDHDTSIISAADDVIEIGPGAGKHGGTVVGQGTVAAIKRDKKSLIAPFLTGTATLRERPVLTDDALWKKGALAIEVAHHFNIQDITARIPKNRFTTVTGMSGAGKTTLVLDSLIPALIATAKKRPLPTHVKAFDNGHIRHVVTVDSVPVGKNVRSTVATYTNILDHLRQLFAATPAAQANSWTASQFSYNVAAGACPTCGGTGQISLDVQYLPDITEVCPQCHGKRYNKQTLTVKWHGYSIADILDLAVDEALPIFKVQSAIANTLQILHDMGLGYLLLGESTPALSGGEAQRLKLTSRIGKRQTGTLFVFDEPSVGLHPLDIQQLVKVFDQLIQQGATVIAIEHDLDVIANADYVIDMGPAGGINGGNIVATGTPLAVSQNPTSVTGQYLKTHLALFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9US20</accession>
    <name>F9US20_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylmethionine deformylase</fullName>
            <ecNumber evidence="2">3.5.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def2</name>
        <name evidence="2" type="ordered locus">lp_2935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.31" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890523.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2935"/>
    <dbReference type="EnsemblBacteria" id="CCC80009">
        <property type="protein sequence ID" value="CCC80009"/>
        <property type="gene ID" value="lp_2935"/>
    </dbReference>
    <dbReference type="GeneID" id="57026280"/>
    <dbReference type="KEGG" id="lpl:lp_2935"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2451"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_3_1_9"/>
    <dbReference type="OMA" id="HEMDHFE"/>
    <dbReference type="PhylomeDB" id="F9US20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2505-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008463">
        <property type="term" value="F:formylmethionine deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="15047" checksum="10735410CA29106D" modified="2011-10-19" version="1">MIRPIVHDPAALSVPADLATPADTQVLTDLLDTLAAHTDNCVGMAANMIGVNKQIIVVQLGPFAIAMINPKIIDHHGTYETKEGCLSLPGERPTSRYHQITVKYKDQHFKPQQQRFNDFTAQIIQHELDHCAGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9US21</accession>
    <name>F9US21_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE2</name>
        <name evidence="11" type="ordered locus">lp_2936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890524.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2936"/>
    <dbReference type="EnsemblBacteria" id="CCC80010">
        <property type="protein sequence ID" value="CCC80010"/>
        <property type="gene ID" value="lp_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2936"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2452"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9US21"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2506-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="36644" checksum="DFCB9C34BF652A7B" modified="2011-10-19" version="1">MTTLAYNGETAIPALAQQRRHQAHHALGTDIDLTLFGSDSDQYLQAACDLIDQYEDRLTVNRTVSEVMAINQAAGQHPVQVSAATYTLVRQAVELSRQHFGFNALIGPLVKLWHIGFTNAHVPEQSAINERLALIDPEAVICNDADFSVLLKVTGMELDLGAIAKGYIADRIQDYWEAFGQRAGMINLGGNLLMVGTSPLHPDGQWRVGIQDPTTDRGNAIASVTIGPCSAVTSGIYERHLEFNGQSYHHILDSQTGYPRQNDLESVTVFSKASIDGEIETTRLFFAGQPIPDWATQRPDIYGAIFVTKQRELQIVGLSPEQVTLLDDRFTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9US75</accession>
    <name>F9US75_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="5">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100862.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0055"/>
    <dbReference type="DNASU" id="1061226"/>
    <dbReference type="EnsemblBacteria" id="CCC77622">
        <property type="protein sequence ID" value="CCC77622"/>
        <property type="gene ID" value="lp_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0055"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.44"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_3_0_9"/>
    <dbReference type="OMA" id="QHHESED"/>
    <dbReference type="PhylomeDB" id="F9US75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-44-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="709"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="789" mass="86254" checksum="D03FB3A352320410" modified="2011-10-19" version="1">MKYIALIGTAAQQSYNRELLQFMKHHFSQRATIDVNEITGIPLFNEPTQNHIPATVQALNDKISQADGVIIGVPEYDHAIPAALKNVIEWLSYQLHPFANKPVMLVGTSLGVQGTCRAQGDLRNILNAPGVDAQVLPGNEYMLSYAAKAFDQNGQMTDAPSIKFLERCFDNFEKYVKALNGTPALNVNWHGNYDVIVLGFGGAGASAARFAADNGAHVLVVDAAPFGREGGNTRYSAQHVVTGESLDKLTAYYQALGAPFSTPTKTLNAYLSGMSKIPAYFEKYLGIKAVSWKHDIKPGDAVAIKKTMAEYPELAGSDTIDFALVHKRDKDAALWKLLRQKVLERADNIDVWLDSRAQHLIQDPNTKVIQGVQIKRGERLLNIHANNGVVLAMGGFENNPELKQTYLHSDNLTPLGTLYNRGDGIKMAQEVDAKMWHMTNYESHGILPGITFKEDANERGRQIEHWPLLKNGSIFVIADDGTRYFQEDAKHRHGHVYTHGSWLIPMNNQHPYLIFDQTQYDAFKQEESQAGQLPYPKFMTKLVSAPTIAQLAAKLGVPANNLQQTVTDFNHYTEVGRDFEFGRDPQTMRQLDDGPYYAIAAANDVLNTQGGPQRNENAQILNVNDEPIPHLFGAGELGGIVANCYQGGGNLAECLIFGKLAGENAARPKVDSESVTANESNGINDLVDGETASNVKLAADQYLGSSNAGLGGKVIVRVTYNDHKIQAVDVIQHHESEDVGLTAIDQIPQEIVAANSTSVDAVSGASASSRAIKEAVQNALKQVKDSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9US94</accession>
    <name>F9US94_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Drug/metabolite transport protein, EamA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101981.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890538.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2959"/>
    <dbReference type="EnsemblBacteria" id="CCC80024">
        <property type="protein sequence ID" value="CCC80024"/>
        <property type="gene ID" value="lp_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2959"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2469"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_9"/>
    <dbReference type="OMA" id="RKFPASM"/>
    <dbReference type="PhylomeDB" id="F9US94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2520-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="157"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="301" mass="32229" checksum="C4BD0A8A250BD7F5" modified="2011-10-19" version="1">MQKKTVGLLLASAGPFLWGSSGTVAQHLFDTTTISPLWLVAVRMLVSGGLLILYGFSRRLPVMVVFHDWRATVRLIVFSLFGMAGVQLTYFMAISTGNAAMAAILQFLSPVMIIIFITATTWQLPGKVDVISVVSAIAGTVLIVTEGHTDSLALPVIAIIWGLLAAVGATIYTLMPTKLLKVYGATPIVGWSMLIGGGLVLVGTGAWHHSPQLTWVAWGQVGFVVIFGTMLAYLFFLQSLEYILPTTASVLGAIEPLAATILSVLFLHVHFNWVGLIGAIMIVGVTILQFAATRANQFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USG5</accession>
    <name>F9USG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102016.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890609.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3042"/>
    <dbReference type="EnsemblBacteria" id="CCC80095">
        <property type="protein sequence ID" value="CCC80095"/>
        <property type="gene ID" value="lp_3042"/>
    </dbReference>
    <dbReference type="GeneID" id="57026363"/>
    <dbReference type="KEGG" id="lpl:lp_3042"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2541"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="PhylomeDB" id="F9USG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2588-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="329"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="574" mass="62877" checksum="37026A05415DC2E1" modified="2011-10-19" version="1">MKILMPYFKRYRLDVWIAMLSVIVLVFATLWQPRLLQVIMEAIIKNDQATVFREGLMLLGLAVLGIIGGIVNTIYAARVALGVATDLRADLYAKVQSLAYADVEKFSPSNLVVRMTNDINQVQQIVMAGFQQITRIPLLFIGALILAVMTMPEQWWVIVVMMAVILGVALIAVRRMTKYFAQTQQDIENVNTVARENLMGIRVVKSFVQEPNEIKKFSAASDELTAVTAKIGYWFAILMPAFFLTANVAVGVAVYLVGQTITTHPAYLAAITSFISYLMQILFAVINGGFLMTFASRAVISLGRIGEVMTTEPSMTYVDGDAAPVAGDIHFDHVTFTYPGDAQPTLKDVTFTVKAGSMLGIVGATGSGKTTLAQLIARLYDPDSGTVSIGGIDVRALPEKALRSTVAYVLQRSTLFSGTIAGNLRQVKPDAQPSHMQWAANIAQSAEFIERLPQTYDAPVEERSQNFSGGQKQRLAITRGVIANPEILILDDATSALDARSEKLVQEALDRELKSTTTVVIAEKIASIIRADQILVLDNGRISGQGTHHELLQDSAIYRAIYQTQKAREEGLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI2</accession>
    <name>F9USI2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102024.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890626.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3064"/>
    <dbReference type="EnsemblBacteria" id="CCC80112">
        <property type="protein sequence ID" value="CCC80112"/>
        <property type="gene ID" value="lp_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3064"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2559"/>
    <dbReference type="eggNOG" id="ENOG5033N2V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541624_0_0_9"/>
    <dbReference type="OMA" id="IMAGPAS"/>
    <dbReference type="PhylomeDB" id="F9USI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2605-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388123" evidence="1">
        <location>
            <begin position="30"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="495" mass="51563" checksum="00DFD6FF1409167E" modified="2011-10-19" version="1">MRNRRVKWLLILVFGILGLLNLLPLEGNAATLTSKMTDVKANAAFQAVPGGNSVGSNVDNGLQAYPALGNVSANYADNGRITRQTTQITMTMTGSITLKSSNSMSKAYFDIMAGPASGSYTGATLVTATPTSLGSGNSIMISSSKQTQTLSVNFQNIKSELPIYIGFRITVNGEEGTYQLGRFNAQTLSPKITGTLYSTDTTIKGTGTPGNTISSNVNGVTTTVGSDGTYTLNLGTALGTLSNVTVTEVDEITGDKGTATAAVTLKKLNITSSKTSVDLYPGELDSLTSDSAVVAWLVKQAGIVATNPDSATDTITYAANETSLASKLSSLAVGSSTTINIYGKGSSGLKSDAKAITVTMRDGTLSLGTLPASLTFGTLTIPFKETLYQPTNAWNITVNDTRKTGSQWYLRATATAMKSSTRTMSGNLIYLNAGNKQVLTNTSVTVSSGKKIAGTTSTNAASGWSSSQGILLDVQPSVQIDSYSGTINWTLQDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL1</accession>
    <name>F9USL1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102040.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3097"/>
    <dbReference type="DNASU" id="1063647"/>
    <dbReference type="EnsemblBacteria" id="CCC80141">
        <property type="protein sequence ID" value="CCC80141"/>
        <property type="gene ID" value="lp_3097"/>
    </dbReference>
    <dbReference type="GeneID" id="57026407"/>
    <dbReference type="KEGG" id="lpl:lp_3097"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2587"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_6_0_9"/>
    <dbReference type="OMA" id="RMAFYRH"/>
    <dbReference type="PhylomeDB" id="F9USL1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2634-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="21319" checksum="4A38C8147F93B1E0" modified="2011-10-19" version="1">MAATNHAQAIKKDSQTYLTTALLQLLRTHDLDTITVTQVVKRAGVSRMAFYRNFTTLEDLLTAYFAPAIAARFQDVLQHVPANRKLLAMGQFFSDFAPTLRLAEQRGFENIIQQLFNANMTNYYQATMTNGMLTAVQLKYWTRFMSAGVYAIWREWLLGGQLESLTTIHEILATLQTATMQALTQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM1</accession>
    <name>F9USM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643401.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3107"/>
    <dbReference type="EnsemblBacteria" id="CCC80151">
        <property type="protein sequence ID" value="CCC80151"/>
        <property type="gene ID" value="lp_3107"/>
    </dbReference>
    <dbReference type="GeneID" id="57026417"/>
    <dbReference type="KEGG" id="lpl:lp_3107"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2597"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330537_0_0_9"/>
    <dbReference type="OMA" id="FSKWIEN"/>
    <dbReference type="PhylomeDB" id="F9USM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2644-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19927" checksum="D7B6CFBB9E52F821" modified="2011-10-19" version="1">MANQRNQRMQATILLAYENLLSDKPFRKITVQDISDAALVHRSTFYKHFQDQYDLLEALFEQKRQQSKLTIDQIFTHPFETLNSFGNARFQETLRHQFNDDAFRDAFLNYLIHLCKDTVDDDQRLVRFLAVGRIKGLTLWITVGNAPYNIFTDTATLDNIFSNPLNTVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX8</accession>
    <name>F9USX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641761.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0165"/>
    <dbReference type="EnsemblBacteria" id="CCC77709">
        <property type="protein sequence ID" value="CCC77709"/>
        <property type="gene ID" value="lp_0165"/>
    </dbReference>
    <dbReference type="GeneID" id="57026996"/>
    <dbReference type="KEGG" id="lpl:lp_0165"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.134"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_2_2_9"/>
    <dbReference type="OMA" id="ADIFATH"/>
    <dbReference type="PhylomeDB" id="F9USX8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-131-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012738">
        <property type="entry name" value="Tscrpt_reg_DhaS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02366">
        <property type="entry name" value="DHAK_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="172" mass="19754" checksum="2EACC5718DA6897B" modified="2011-10-19" version="1">MAYITKKKIAQAFHDVVLVRGFSRTSVTAIMSTADFRRQTFYDYFQDKYELLTWFIDDTLTETVEHNLNYLPWIDIIKLVCYELDANRQFYAECINTQHEIDVTALVGNHLATLLTELTHANTTETAALIWLLCLGIAQSLTHNIVANHPEDYEVLSQHAIAAIEMTLEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9USZ5</accession>
    <name>F9USZ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641779.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0183"/>
    <dbReference type="EnsemblBacteria" id="CCC77726">
        <property type="protein sequence ID" value="CCC77726"/>
        <property type="gene ID" value="lp_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="57027013"/>
    <dbReference type="GeneID" id="66448304"/>
    <dbReference type="KEGG" id="lpl:lp_0183"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.151"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163406_0_0_9"/>
    <dbReference type="OMA" id="AYIPQIM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-148-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="90" mass="10201" checksum="5944FEC048F2BF72" modified="2011-10-19" version="1">MDPKRVKYLKLISKLATFTCIAMYVSYIPQIISNFSGDPVSPLQPLVAMINGILWTGYGWFKTYKDWPVIISNVPGVIFGFITVLTVYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT06</accession>
    <name>F9UT06_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888251.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0199"/>
    <dbReference type="EnsemblBacteria" id="CCC77737">
        <property type="protein sequence ID" value="CCC77737"/>
        <property type="gene ID" value="lp_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="57027024"/>
    <dbReference type="KEGG" id="lpl:lp_0199"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.163"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053304_2_0_9"/>
    <dbReference type="OMA" id="HVTYYLA"/>
    <dbReference type="PhylomeDB" id="F9UT06"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-159-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="31987" checksum="53D6C678C59BBB63" modified="2011-10-19" version="1">MNIELFIARRKALGLSQKALADGICTQATLSKFENNGKAPAIRIVAQLCQRLNLQLEDVFPTERVADAAVLKILEQVEFDLITTEYQDAEVQLEKAADMPRHDRETKLQYCYLKGYVAALNHHPISDVIFNFDQIITDLDEAHITIYTQLAYCGIGIAYQQNQDNDKAQYYFEKVRHALPNLPLETTASVWRVINLAYYTGAFYANINDTPRSLQLLNYGIEICARFHVTYYAARIKFLQAQLSDEPDQIHEYLNDAAALARMNNNRQLLKNISSYSDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT10</accession>
    <name>F9UT10_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">serA</name>
        <name evidence="14" type="ordered locus">lp_0203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
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    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="CCC77741">
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    <dbReference type="PATRIC" id="fig|220668.9.peg.167"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="YGNIGTQ"/>
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    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:L-serine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="315"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC77741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="392" mass="41769" checksum="B8DF8891171FAB16" modified="2011-10-19" version="1">MYQVKTYNAIAPAGLNTFTADYTLNQSEHPDAYLIRSVNLHTETLPSSLKVIVRAGAGVNNIPIDQATANGTAVFNTPGSNANAVKELIIGLLIMASRNLIAATTYSAQHTEADISQRTEHDKTQFNGIELTGKTLAVIGLGHVGALVANAALSLGMNVIGYDPYLSADAAWNIAKQVQRAATLPDAVKQADFVTVHVPKNADTLHLINKDALAAMPTGVQLFNYSRLGIVDNTAVMNALATGQVAHYYTDFGEPQLANQSAVTVTPHIGGSTIEAEINGATQAARTIMTYLETGNVHAAINLPDLNVPFNAAYRFTVIHENVPNMVSQITAKLAAANLNITTMANAAKHQIAYTIIDVDDLQQPQQADLIAELSKIPAVSRVRLLKRGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT90</accession>
    <name>F9UT90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890722.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3177"/>
    <dbReference type="EnsemblBacteria" id="CCC80208">
        <property type="protein sequence ID" value="CCC80208"/>
        <property type="gene ID" value="lp_3177"/>
    </dbReference>
    <dbReference type="GeneID" id="57026470"/>
    <dbReference type="GeneID" id="66450729"/>
    <dbReference type="KEGG" id="lpl:lp_3177"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2656"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134233_0_0_9"/>
    <dbReference type="OMA" id="CGTENDD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2696-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF4064"/>
    </dbReference>
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        <property type="entry name" value="DUF4064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4064" evidence="2">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="12351" checksum="676DA4EE758D451C" modified="2011-10-19" version="1">MSKYQNNEVTPVAHQSRTAELVLGIIGGIFGIIAGLLAMTIGGIGSALETSGSAGVSNLGVGCIIVSVLAIILSVMINRNHVLMGWLIILCGILNFVFVSFFGILSGLLIVIAGGLALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD1</accession>
    <name>F9UTD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3228"/>
    <dbReference type="EnsemblBacteria" id="CCC80249">
        <property type="protein sequence ID" value="CCC80249"/>
        <property type="gene ID" value="lp_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3228"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2697"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805885_0_0_9"/>
    <dbReference type="OMA" id="WHTETGL"/>
    <dbReference type="PhylomeDB" id="F9UTD1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2737-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="97"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="349" mass="39235" checksum="9F5D6A00E2AB67D3" modified="2011-10-19" version="1">MIIDANVYWLPDELFTDPALQAKFIQAVDNGQDSRATVSTNADGSKKIVIEEPIGQSSLDYFQNDYQLDHQLRDMDAGQVDMAVLKLPGCEEWLNLDLCRVFNRAVAKHVQKSHGRMVALATVPPYADEENLAELDYCIDELGLCGLQLSTHYADGYLDSPVYRDFFRHVAAKNIPVYVHHSPVPMEYGAIKDYENLRRSYGRCEDQITAIGREVFSDLFVELPDLQLIHSMLGGGFFTYKTMLLPHDSGNGRFDTTNSTSVKHRLEHNIFYEVSHAQPWGADNIEMAIKVLGANNVIYGSSYPVKTAWMTAGPAMVRKLDVDTNVIENVLSDNAKRVYQISHSHQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE4</accession>
    <name>F9UTE4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642470.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890776.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3245"/>
    <dbReference type="EnsemblBacteria" id="CCC80262">
        <property type="protein sequence ID" value="CCC80262"/>
        <property type="gene ID" value="lp_3245"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3245"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2710"/>
    <dbReference type="eggNOG" id="COG4908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050810_1_0_9"/>
    <dbReference type="OMA" id="CQISAND"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2750-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="424" mass="47977" checksum="D230BF72ADB45490" modified="2011-10-19" version="1">MIGGLIVYYRGEALDFLNMLHTTGAAPLMRSRIVFSSQIDVERLKAAVLASAQIVPEIFGHYQADRNRFVVTDQPVNQVIQEVQSPYSPENTDFDFTNSPQLRLFVIHHGDYDVLQAFMSHLLTDNRGFKEYLYLLAQAYNYADLTNLHNERRLRPVITKLQRQFARPHGHAPIVTGMVKLPHYPGINLRHGGHVMLSSTQFMRVRRMAKAQDVGISEAILAAYAKALQVLTGHTTVTLPCPIDLRRFTTEDANVTQIANLTVNVFLTIKVDIDAPFSELVNQVHDLLTVERTRVAFLYRLSNLQKMNHTMPITVMRKMTKRWLPQPALRYTNFGVVDQERLKFHDLTVVNCVFSGAFQCSPVMEIAASTFAGTCTLSFNSTGSERDYQLSMKILENIQAQLLVWAQADAQVATTDNVTLRHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF0</accession>
    <name>F9UTF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890782.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80268">
        <property type="protein sequence ID" value="CCC80268"/>
        <property type="gene ID" value="lp_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3252"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2716"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_9"/>
    <dbReference type="PhylomeDB" id="F9UTF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2756-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20933" checksum="049DE9F01611409D" modified="2011-10-19" version="1">MKNMFVGPHVALAVPQPEDFDEISDWYTDADFVRKMDTAAARPLTGEELERTYRNLDRNTEYYFHVHSLEDDHLLGFVTLFNIEWHNQVAQLAIAIGDPDERGHGYGTETLSLILNYAFNELNLYKVCLDVIATNPAAIAVYQNSGFEFEGTNKRAIKRDGQRIDLYHMGLFAADFQPRVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTG6</accession>
    <name>F9UTG6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ordered locus">lp_3273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890798.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3273"/>
    <dbReference type="EnsemblBacteria" id="CCC80284">
        <property type="protein sequence ID" value="CCC80284"/>
        <property type="gene ID" value="lp_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3273"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2733"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_1_1_9"/>
    <dbReference type="OMA" id="WHLVVYR"/>
    <dbReference type="PhylomeDB" id="F9UTG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2772-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EnsemblBacteria" id="CCC80329">
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            <dbReference type="EMBL" id="CCC80329.1"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
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</entry>
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    <accession>F9UTS8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="77"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77848.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="117" mass="13272" checksum="DEAB9865D2C970D6" modified="2011-10-19" version="1">MQIDHGSRQPYYAQIVTGIEQDIAHGVLQSGEQLPSVREMARQHLLNPNTVSKAYKRLETQQIIETVPGKGTYVKVVDSTLFRQELREQFTQIVRLAGQRGVSIAELHGWLDQMGEK</sequence>
</entry>
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    <accession>F9UU10</accession>
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        <submittedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641987.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888444.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU10"/>
    <dbReference type="STRING" id="220668.lp_0424"/>
    <dbReference type="EnsemblBacteria" id="CCC77930">
        <property type="protein sequence ID" value="CCC77930"/>
        <property type="gene ID" value="lp_0424"/>
    </dbReference>
    <dbReference type="GeneID" id="57024226"/>
    <dbReference type="KEGG" id="lpl:lp_0424"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.345"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047946_0_0_9"/>
    <dbReference type="OMA" id="IGNHGIT"/>
    <dbReference type="PhylomeDB" id="F9UU10"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-352-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005696">
        <property type="entry name" value="MesE/LcnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01000">
        <property type="entry name" value="bacteriocin_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="458" mass="50963" checksum="B9941351AF4265B1" modified="2011-12-14" version="1">MRKDLLESGEFYGIRFQNFSTLLIIPVTLLLIGTILFSLVAKREIVINGTGTVQPTGTVPVIQATVNSAIKKNYLVEGARVKKGQKLLVYTNVFNRNKLREDNVSKRQLQRQVTALDHFKDGINTDSDVFPTTDEFGYRELLQSYLKQRQIYLTENQMLAAKSSAASTKKATLTKTAQQVVSNTKTNLDAYQALYNAVANGSKYANSAKYGSVFNEYVAKSKEANNANDKKEVKSATLADIQQQIDTLQDSLSSAKVQLEELQDFDDTKYSVETNNTKLAMLKNDQLSEVAEKRMKAEQDLRTVKADIDSLTTQSKSYTIKATKAGVLHVADNYRGAKYVSSGAEIAKILPIIKQQRRVNVKLYISTADISSVKVKQAIRFKVTRNVPKPIILDGVVTKIGVSPVEESKATFYEVTAAVPITADQAQLLRYGMIGQTAIITGKVTWFDYYKDKVLDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU24</accession>
    <name>F9UU24_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts8C</name>
        <name evidence="11" type="ordered locus">lp_0439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0439"/>
    <dbReference type="EnsemblBacteria" id="CCC77944">
        <property type="protein sequence ID" value="CCC77944"/>
        <property type="gene ID" value="lp_0439"/>
    </dbReference>
    <dbReference type="GeneID" id="57024239"/>
    <dbReference type="KEGG" id="lpl:lp_0439"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.359"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_2_9"/>
    <dbReference type="OMA" id="IHGPNTI"/>
    <dbReference type="PhylomeDB" id="F9UU24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-365-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="451" mass="49514" checksum="961C0BF151CD8A22" modified="2011-10-19" version="1">MNGFNVFMEKHIVPFAVKLNEQRHVAAIRDAFMYTFPITMAASLVILINNLVFSKTGFIAQILFLPKFFPHLENAQKLLTSVTNGTMNILSIFIAYLVARNLAKYFKADDMLVGMTGIACFMILYSPSIIKDGVTYLPTTYLGAQGLFVAMIVGGLVGEFLPRLTRIKKMQIKMPEMVPPAVARSFNGLIPIVIMIMLFSMLNYGLSLISPQGINDIIYKSIQTPLTHIGVNLFGVIIIAIVQNLLWLVGIHGPNTLNALRSIIFTEADLKNQTFINAHGTAWGVPNRATWSVLNDVFANMGGSGMTLGLIIAIFLVSRRKDYREIAKLALVPGLFNINEPLMFGLPIVLNPIMAIPFVLTPVINILVGYTVTVIFNWIPTPAFGLTWTTPGPLMPFLGTGGNWLGLIIGFVCLGISVLTYMPFVLAANKMMAADSQSKQDTDTTTETVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU39</accession>
    <name>F9UU39_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNase, TatD family</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643825.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU39"/>
    <dbReference type="STRING" id="220668.lp_0456"/>
    <dbReference type="EnsemblBacteria" id="CCC77959">
        <property type="protein sequence ID" value="CCC77959"/>
        <property type="gene ID" value="lp_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="57024254"/>
    <dbReference type="KEGG" id="lpl:lp_0456"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.376"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_9"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="PhylomeDB" id="F9UU39"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-380-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="258" mass="29415" checksum="D1A68120DB7FC952" modified="2011-10-19" version="1">MRIFDSHTHLNSEEFIQEVPRYLQQAADLDVTRMAIVGSNTQLNADAIKLAETYPQLVAIVGWHPEDAKNYDQAAEKLLIEQVQHPKVVALGEIGLDYHWDTSPQDVQRQVFARQVAIAKEMQLPISVHNRDAFEDTYKILKAADIRDTGGVMHSFNGDPEWLKRFLDLGMHISYSGVASFKNAREVHESVKQTPLTQMLVETDAPYLTPEPYRGKQNEPGYTRYVVEAIAKLRETTPEIIAAQTYQNAEEFFKIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUF6</accession>
    <name>F9UUF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102185.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3490"/>
    <dbReference type="EnsemblBacteria" id="CCC80458">
        <property type="protein sequence ID" value="CCC80458"/>
        <property type="gene ID" value="lp_3490"/>
    </dbReference>
    <dbReference type="GeneID" id="57026704"/>
    <dbReference type="GeneID" id="66450956"/>
    <dbReference type="KEGG" id="lpl:lp_3490"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2906"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163878_0_0_9"/>
    <dbReference type="OMA" id="MVNTWNS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2946-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13372" checksum="AF4D2D76FBC45573" modified="2011-10-19" version="1">MDPKFIEVIKDTTPATIVTVNAAPAHVVNTWSHYMQLIDDHTLLIPSAGMHSIEADFATDNHITIAVGSYKVPGTTGTGCGFHIHGTGKFETSGAYFDQMHTKFDWIRATLVVTIDDVEQKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O08319</accession>
    <accession>F9UL04</accession>
    <name>ARGJ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Ornithine acetyltransferase</fullName>
                <shortName evidence="1">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglutamate synthase</fullName>
                <shortName evidence="1">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">argJ</name>
        <name type="ordered locus">lp_0529</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="1"/>
    <dbReference type="EC" id="2.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08319"/>
    <dbReference type="SMR" id="O08319"/>
    <dbReference type="STRING" id="220668.lp_0529"/>
    <dbReference type="MEROPS" id="T05.002"/>
    <dbReference type="EnsemblBacteria" id="CCC78019">
        <property type="protein sequence ID" value="CCC78019"/>
        <property type="gene ID" value="lp_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0529"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.437"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_9"/>
    <dbReference type="PhylomeDB" id="O08319"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-440-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000002177" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000002178" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="1">
        <location>
            <begin position="189"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <sequence length="402" mass="43017" checksum="40C14BA9CD5F335F" modified="2011-11-16" version="2">MQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLLLNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPKTVCVQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANGLADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNWGRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINASYHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>P71479</accession>
    <accession>F9URI6</accession>
    <name>PYRR1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Bifunctional protein PyrR 1</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Pyrimidine operon regulatory protein 1</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Uracil phosphoribosyltransferase 1</fullName>
                <shortName>UPRTase 1</shortName>
                <ecNumber>2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="primary">pyrR1</name>
        <name type="synonym">pyrR</name>
        <name type="ordered locus">lp_2704</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639428.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890339.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P71479"/>
    <dbReference type="SMR" id="P71479"/>
    <dbReference type="STRING" id="220668.lp_2704"/>
    <dbReference type="EnsemblBacteria" id="CCC79825">
        <property type="protein sequence ID" value="CCC79825"/>
        <property type="gene ID" value="lp_2704"/>
    </dbReference>
    <dbReference type="GeneID" id="49394818"/>
    <dbReference type="GeneID" id="57026085"/>
    <dbReference type="GeneID" id="66450362"/>
    <dbReference type="KEGG" id="lpl:lp_2704"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2264"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_9"/>
    <dbReference type="OMA" id="PVSANYV"/>
    <dbReference type="PhylomeDB" id="P71479"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2316-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000183041" description="Bifunctional protein PyrR 1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="180" mass="19824" checksum="5ADBBFA61AA3172D" modified="1997-02-01" version="1">MAREVVDAMTMRRALTRITYEIIEQNKGVGNLVFIGIKTRGIFLAQRLAQRLKQLEGVDVPVGSLDITLYRDDHHAVDVAGQAKLNGADIPVDINGKHVILVDDVLFTGRTVRAALDALMDHGRPAKISLAVLVDRGHRELPIRPDFIGKNIPTALDEQVSVALEEHDGHDGISIEKLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SB0</accession>
    <accession>F9UUI7</accession>
    <name>MURQ2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate etherase 2</fullName>
            <shortName evidence="1">MurNAc-6-P etherase 2</shortName>
            <ecNumber evidence="1">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate hydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate lyase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murQ2</name>
        <name type="ordered locus">lp_3523</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891003.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SB0"/>
    <dbReference type="SMR" id="Q88SB0"/>
    <dbReference type="STRING" id="220668.lp_3523"/>
    <dbReference type="PRIDE" id="Q88SB0"/>
    <dbReference type="EnsemblBacteria" id="CCC80489">
        <property type="protein sequence ID" value="CCC80489"/>
        <property type="gene ID" value="lp_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3523"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2937"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_9"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="PhylomeDB" id="Q88SB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2977-MON"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000249632" description="N-acetylmuramic acid 6-phosphate etherase 2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <sequence length="296" mass="31441" checksum="99BE8A46124D39BB" modified="2003-06-01" version="1">MNLEKLTTETRNQKTMALDMLSVKEMLELMNQEDQRVPVAVSKELPQIECAVDKIVANFKAGGRLIYMGAGTSGRLGVLDAAECVPTFGTSPEMVQGLIAGGMSAMTVAVEGAEDSIELGQQDLVDLHLTSHDTVVGVAASGRTPYVIGGLDYACEVGATTVSIACNADASISQHAQIPIEVEVGPEILTGSTRLKSGTAQKLVLNMLSTASMVGIGKVYKNLMVDVKPTNEKLVERAKRIIVQATDCSDETAVKVFMTADQNVKLAIVMVLTNMSKAEASVRLDHANGFVRQAVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UD8</accession>
    <accession>F9UR77</accession>
    <name>HISZ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisZ</name>
        <name type="synonym">hisX</name>
        <name type="ordered locus">lp_2561</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644683.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890230.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UD8"/>
    <dbReference type="SMR" id="Q88UD8"/>
    <dbReference type="STRING" id="220668.lp_2561"/>
    <dbReference type="DNASU" id="1062763"/>
    <dbReference type="EnsemblBacteria" id="CCC79716">
        <property type="protein sequence ID" value="CCC79716"/>
        <property type="gene ID" value="lp_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2561"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2152"/>
    <dbReference type="eggNOG" id="COG3705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_0_0_9"/>
    <dbReference type="OMA" id="ELVMPPM"/>
    <dbReference type="PhylomeDB" id="Q88UD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2208-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171039" description="ATP phosphoribosyltransferase regulatory subunit">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <sequence length="383" mass="42605" checksum="0DCE7B9522E346CA" modified="2003-06-01" version="1">MLKHLLPLGTRDEFGRRARTKQHLIAVIQAHFKQRGLAPIATPLLENEAVFDPYQMGNYQLYRLFGNDGRTLVLRPDMTLPVARFISATNVPLPQKFGYVGDIFRVSRQLSGSYNQITQAGVELVGYASLKAEFECLTIANQLSSELIADAVEIELGDAQFAQRVVASLTGDEGEQQAILTALFDKQVPRYTKLIAKYRAQPLYDFLKAWPRLFGRPECIFKELAAAPLPETVQPSLKRLQTVVAWMQQTMPEQVISVDLSSQAPQKYYTGLTFRGYSQAGAGYLFSGGRYDKLLTNFQAEAEPAVGMGLNVDLLTTLATDQQTAYAEQLIYFEPEQWSQAEAYLAKQPHAILSLADDLAGARIEAQRLNAQLIDLTGGMTND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UU3</accession>
    <accession>F9UQR3</accession>
    <name>ATPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">lp_2364</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UU3"/>
    <dbReference type="SMR" id="Q88UU3"/>
    <dbReference type="STRING" id="220668.lp_2364"/>
    <dbReference type="EnsemblBacteria" id="CCC79552">
        <property type="protein sequence ID" value="CCC79552"/>
        <property type="gene ID" value="lp_2364"/>
    </dbReference>
    <dbReference type="GeneID" id="57025896"/>
    <dbReference type="GeneID" id="66450109"/>
    <dbReference type="KEGG" id="lpl:lp_2364"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1997"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_9"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="PhylomeDB" id="Q88UU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2036-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254281" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="467" mass="50831" checksum="9121D791610FE097" modified="2003-06-01" version="1">MSTGKVVQVIGPVVDVEFSLNDKLPDINNALIIQKDNDDTLTVEVSLELGDGVVRTVAMDGTDGLRRGMTVEDTGSSITVPVGKETLGRVFNVLGETIDGGPEFGPDAERNPIHRDAPKYDELTTSTEVLETGIKVIDLLAPYVRGGKIGLFGGAGVGKTVLIQELIHNIAQEHNGISVFTGVGERTREGNDLYFEMKASGVLKNTAMVYGQMNEPPGARMRVALTGLTIAEYFRDVQGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAVYVPADDYTDPAPATTFAHLDATTNLERSLTEQGIYPAVDPLASSSIALDPSIVGEEHYQVATEVQRVLQRYRELQDIISILGMDELSDEEKTTVARARRIQFFLSQNFFVAENFTGQPGSYVPINDTIKGFKEILEGKYDDLPEDAFRQVGKIDDVVEKAKSMVTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V96</accession>
    <accession>F9UQB1</accession>
    <name>MNMA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="synonym">trmU</name>
        <name type="ordered locus">lp_2178</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V96"/>
    <dbReference type="SMR" id="Q88V96"/>
    <dbReference type="STRING" id="220668.lp_2178"/>
    <dbReference type="EnsemblBacteria" id="CCC79400">
        <property type="protein sequence ID" value="CCC79400"/>
        <property type="gene ID" value="lp_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2178"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1841"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_1_0_9"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="PhylomeDB" id="Q88V96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1861-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000121643" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="1">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="374" mass="42041" checksum="C4D6ECD2F10E04A0" modified="2003-06-01" version="1">MTDHSNTRVVVGMSGGVDSSVVALLLKQQGYDVVGVFMKNWDDTDENGVCTATEDYKDVAKVADKIGIPYYSINFEKEYWDRVFTYFLDEYKKGRTPNPDVICNKEIKFKAFLDYAMDLGADYIATGHYARLQHDEDGTMHLLRGVDSNKDQTYFLSQLDSKTLQKVMFPLGEMVKPDVRKLALNAGLATAKKKDSVGICFIGEKNFKEFLGHYLPATPGKMMTFDGQVKGEHAGLMYYTIGQRRGLGIGGDGEDNEPWFVVGKDLKKNILYVGKGYHNPHLYATHLKASDLHFVTDEDLGNDFHVTAKFRYRQKDSGVTVHFNDDHTEVTVTFDDPVRAITPGQAVVFYNGEECLGSGMIDAAYNDERVLQYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VD4</accession>
    <accession>F9UQ71</accession>
    <name>RS20_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">lp_2126</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889874.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VD4"/>
    <dbReference type="SMR" id="Q88VD4"/>
    <dbReference type="STRING" id="220668.lp_2126"/>
    <dbReference type="EnsemblBacteria" id="CCC79360">
        <property type="protein sequence ID" value="CCC79360"/>
        <property type="gene ID" value="lp_2126"/>
    </dbReference>
    <dbReference type="GeneID" id="57025666"/>
    <dbReference type="GeneID" id="66449895"/>
    <dbReference type="KEGG" id="lpl:lp_2126"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1801"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_1_1_9"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="PhylomeDB" id="Q88VD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1821-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000224944" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <sequence length="84" mass="9085" checksum="9CEA7456CEA873B2" modified="2003-06-01" version="1">MPIIKSAIERVKTNNKANVRNTAQMSAMRTAVKKFEAAKTAGADNVDDLYLAATSAVDKAASKGLIKRNKAARDKSRMAARYAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ5</accession>
    <accession>F9UQ09</accession>
    <name>EFTS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">lp_2054</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644498.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889812.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ5"/>
    <dbReference type="SMR" id="Q88VJ5"/>
    <dbReference type="STRING" id="220668.lp_2054"/>
    <dbReference type="EnsemblBacteria" id="CCC79298">
        <property type="protein sequence ID" value="CCC79298"/>
        <property type="gene ID" value="lp_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2054"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1739"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_2_9"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="PhylomeDB" id="Q88VJ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1759-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161136" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="292" mass="31616" checksum="32B436F646793E0B" modified="2003-06-20" version="1">MAKISAAQVKELRDKTGVGMMDAKKALVETEGDMEKAVDVLREKGVAKAEKKSGRVAAEGIAAVAIKDNKAAIVEINCETDSVASTDKFKNLVTEVADKIAEEEPASVDDALALKTANGTVKDDVIETTQVTGEKISLRRFQVVEKGADQSFGSYIHNGGQIAALVVLDGADSATAKDVAMHVAAINPEYVNREQVPADRLAHEKDVLVKEALNEGKPEKIVEKMVEGRLNKWLSEISLDDQEFVKDSDQTVAHFVESKGGKVSSFIRFEVGEGIEKKADNFIDEVMNQIKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VL0</accession>
    <accession>F9UPZ4</accession>
    <name>AROC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="ordered locus">lp_2037</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644493.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889797.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VL0"/>
    <dbReference type="SMR" id="Q88VL0"/>
    <dbReference type="STRING" id="220668.lp_2037"/>
    <dbReference type="EnsemblBacteria" id="CCC79283">
        <property type="protein sequence ID" value="CCC79283"/>
        <property type="gene ID" value="lp_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2037"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1722"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_9"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="PhylomeDB" id="Q88VL0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1744-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000322406" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="389" mass="41488" checksum="1947A9F5F6E4B0CD" modified="2003-06-01" version="1">MINYVTAGESHGPQLTGVLTGIPAGLQLDIDAINTGLAARQGGFGRGNRQQIEHDTVQIIGGVRHGVTLGSPIALTIMNRDHAHWAAIMDPVSPATATNTLRQVTRPRPGHADLVGGMKYGHRDLRNVLERSSARETAMRVAIGQICKQLLAQLDIHLVGYVQQIGPKQVTADLTLSVDQLQAQIAQNDLRLPDAALVPEIHELITATKKAGDTLGGVIRVVAENVPAGLGSYTNWDTKLDGQLAAAVMGVNAMKGVEIGDGFAAASHYGSQVMDEISWDEHAGWSRLTNHLGGFEGGMTNGMPIVVKAAMKPIPTLYKPLQSVDIATKVSQKASVERSDTTAIVPASIVVESVVAIELTRALTATFDGSNLARLQQTVTAYREELRQY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VY7</accession>
    <accession>F9UPL8</accession>
    <name>SCPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">scpA</name>
        <name type="ordered locus">lp_1890</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ScpA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VY7"/>
    <dbReference type="SMR" id="Q88VY7"/>
    <dbReference type="STRING" id="220668.lp_1890"/>
    <dbReference type="EnsemblBacteria" id="CCC79157">
        <property type="protein sequence ID" value="CCC79157"/>
        <property type="gene ID" value="lp_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1890"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1593"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_1_9"/>
    <dbReference type="PhylomeDB" id="Q88VY7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1619-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211087" description="Segregation and condensation protein A">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <sequence length="255" mass="29190" checksum="778AB4BAC5B247B0" modified="2011-11-16" version="2">MTNNQQQPITIKISEFEGPLDLLLHLIRQNKMDIYDIPIAAITQQYLDYLHSMRALKLDIAGDYLVMAATLMTIKSRFLLPQPEPDEMDEDNEDDDPRDSLVAELLAYKVYQEAAGELREKEQARHQHFTREAMLVPADLSAPKLTAGITLDDLQAAFRQLVAKRRRVRPLTKTVVAETINIDERMTQITTQLQHQPQGLDFADLFTVSASDEMLVTTFMAVLELTKQDQVALQQAEPLSPIHLYLRQDEQHDEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XV1</accession>
    <accession>F9UMP1</accession>
    <name>ECFA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <shortName evidence="1">ECF transporter A component EcfA2</shortName>
            <ecNumber evidence="1">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ecfA2</name>
        <name type="synonym">cbiO2</name>
        <name type="ordered locus">lp_1074</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888994.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XV1"/>
    <dbReference type="SMR" id="Q88XV1"/>
    <dbReference type="STRING" id="220668.lp_1074"/>
    <dbReference type="EnsemblBacteria" id="CCC78480">
        <property type="protein sequence ID" value="CCC78480"/>
        <property type="gene ID" value="lp_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1074"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.909"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="PhylomeDB" id="Q88XV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-923-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51246">
        <property type="entry name" value="CBIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092022" description="Energy-coupling factor transporter ATP-binding protein EcfA2">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01710"/>
        </source>
    </evidence>
    <sequence length="295" mass="32302" checksum="B3DC667CEB1E7949" modified="2003-06-01" version="1">MAITFKQVDFTYQPGTPFETKALTDINVTIPTGSYTALIGHTGSGKSTLLQHLNALLKPTSGTVTIGERVITPTTSNKDLKRLRQHVGIVFQFPESQLFEETVAKDIAFGPQNFGASEADALKTAAEMLALVGLDESLLTRSPFDLSGGQMRRVAIAGVLAMQPQVLVLDEPTAGLDPQGRLDMMEMFARLRHERDLTVVLVTHQMDDVANYADNVIVMDRGQIVKTGTPREIFKDPAWLTAHQLGLPKTTAFAHTLQKQGWQFNEWPLTEDELAAAIVQQLPPNAMGEVAAHDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YI2</accession>
    <accession>F9UM04</accession>
    <name>WHIA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">whiA</name>
        <name type="ordered locus">lp_0781</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888757.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YI2"/>
    <dbReference type="SMR" id="Q88YI2"/>
    <dbReference type="STRING" id="220668.lp_0781"/>
    <dbReference type="EnsemblBacteria" id="CCC78243">
        <property type="protein sequence ID" value="CCC78243"/>
        <property type="gene ID" value="lp_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="66448745"/>
    <dbReference type="KEGG" id="lpl:lp_0781"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.660"/>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053282_1_0_9"/>
    <dbReference type="OMA" id="CDAEAAW"/>
    <dbReference type="PhylomeDB" id="Q88YI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-678-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000376503" description="Probable cell division protein WhiA">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <sequence length="310" mass="35112" checksum="5DB809ED4657E16B" modified="2003-06-01" version="1">MSYASDVKKELTNLAVHRENAKAELMALIRMNGAISIANHHFILNIQTENPAIARRIYRLLKQFYDVDSELIVRRKMKLNKNNLYIVRLKTGTDMVLADLGILKDYQIVEVAPTEVLTDDAAVRSYLRGAFLAGGSVNNPETSRYHLEIYSLYEEHNHMISEMMNQYGLNSRTTDRRGGFITYIKEAEKIADFLSLVGATNAMLKFEDIRIMRDMRNSVNRLVNCENANMDKVANASSKQIENILLIDATVGLQQLPPKLQEVAVARLEHREVSLKELGTLVPGGPISKSGINHRLRKINQFAEQLQKDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YI4</accession>
    <accession>F9UM02</accession>
    <name>Y779_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein lp_0779</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0779</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888755.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YI4"/>
    <dbReference type="SMR" id="Q88YI4"/>
    <dbReference type="STRING" id="220668.lp_0779"/>
    <dbReference type="EnsemblBacteria" id="CCC78241">
        <property type="protein sequence ID" value="CCC78241"/>
        <property type="gene ID" value="lp_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="57024482"/>
    <dbReference type="GeneID" id="66448743"/>
    <dbReference type="KEGG" id="lpl:lp_0779"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.658"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_9"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="PhylomeDB" id="Q88YI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-676-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000107722" description="Nucleotide-binding protein lp_0779">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="294" mass="33321" checksum="D36FB1B3CC077985" modified="2003-06-01" version="1">MAESLQLVIISGMSGAGKTVAVQSFEDLGYFCIDNMPPALLPKFSELVEESGKIKKVALVIDLRSRAFYDEIMDMLANLDNTDFVSTRILFLDASNEELVSRYKETRRSHPLAMEGRVMDGVRKERELLAPLKDRASYVIDTSTLTPRELRESIFDKFETDQDETFHIEMLSFGFKYGLPIDADIVMDVRFLPNPYYIPELKKLTGLDKPVADYVMQQPATEAFYQQFLSMLESIMPGYEAEGKSSLTIAIGCTGGQHRSVALTQRIGEALAKHYKVHISHRDIEKRKETVNRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YX9</accession>
    <accession>F9UL75</accession>
    <name>SYC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">lp_0610</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888604.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YX9"/>
    <dbReference type="SMR" id="Q88YX9"/>
    <dbReference type="STRING" id="220668.lp_0610"/>
    <dbReference type="EnsemblBacteria" id="CCC78090">
        <property type="protein sequence ID" value="CCC78090"/>
        <property type="gene ID" value="lp_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0610"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.510"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_9"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="PhylomeDB" id="Q88YX9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-521-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159414" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="470" mass="52764" checksum="ED4D0933416799AE" modified="2003-06-01" version="1">MLSVFNTLTRQKEPFKPITPGVVKMYVCGPTVYNYIHIGNARSAIAFDTIRRYFEYCGYHVDYVSNFTDVDDKLIKRAAEDHTTVPAVADRFIKAFMEDTTAVNIEPATVHPRASENIPEIIAFVQALIEKGYAYESAGDVYYRARKFKKYGQLSDQRIDDLEVGASQHTADEETDRKEDPIDFALWKAAKPGEISWESPWGAGRPGWHIECSVMSTKYLGDTFDIHGGGQDLEFPHHENEIAQSEAKTGKTFANYWLHNGFVTVGDDNEKMSKSLGNFVTVHDIIKTVDPQVLRFFMATTQYRRPIQYTQANLDEAANNLDKLRNAYRNLTFRLQDATNGTDTAVAEQLQTLITNFGTAMDDDFNVQNGVAAVYELAKLANVYAAKATVQKETLIALQKALVQLTGVFGVTFETANATLADDAIQALIDEREAARKAKDFAKADQIRDDLKVQGIMLEDTPQGVRFRKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8GH68</accession>
    <accession>F9UTN2</accession>
    <name>MNTH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mntH</name>
        <name type="synonym">mntH1</name>
        <name type="ordered locus">lp_0275</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2001-09" db="EMBL/GenBank/DDBJ databases">
            <title>Identification and transcriptional analysis of an ABC-transporter and two Nramp type transporters that are induced upon manganese starvation in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Nierop Groot M.N."/>
                <person name="Pentcheva E."/>
                <person name="Verdoes J.C."/>
                <person name="Klaassens E."/>
                <person name="de Vos W.M."/>
                <person name="Delcour J."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="AF416709">
        <property type="protein sequence ID" value="AAO15439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888316.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8GH68"/>
    <dbReference type="SMR" id="Q8GH68"/>
    <dbReference type="STRING" id="220668.lp_0275"/>
    <dbReference type="EnsemblBacteria" id="CCC77802">
        <property type="protein sequence ID" value="CCC77802"/>
        <property type="gene ID" value="lp_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0275"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.229"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_9"/>
    <dbReference type="OMA" id="SPKWLRY"/>
    <dbReference type="PhylomeDB" id="Q8GH68"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-224-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000212621" description="Divalent metal cation transporter MntH">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="464" mass="50352" checksum="ACFFE2C06CD51FAB" modified="2003-03-01" version="1">MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVAVGYMDPGNWITSIAGGSQYKYALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERTSKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLIVGILITTADVLILLLLMKLGFRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGATVMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFFGTKGDLGRFVDLYNALGDSKVVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGFIRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLLTMSQVFLSIALPFAMIPLVMFTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL70</accession>
    <name>F9UL70_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888599.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0603"/>
    <dbReference type="EnsemblBacteria" id="CCC78085">
        <property type="protein sequence ID" value="CCC78085"/>
        <property type="gene ID" value="lp_0603"/>
    </dbReference>
    <dbReference type="GeneID" id="57024380"/>
    <dbReference type="GeneID" id="66448647"/>
    <dbReference type="KEGG" id="lpl:lp_0603"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.504"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_2_2_9"/>
    <dbReference type="OMA" id="KHEFDTT"/>
    <dbReference type="PhylomeDB" id="F9UL70"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-516-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="11220" checksum="0CC90BEADD08AD80" modified="2011-10-19" version="1">MEFTREAHRFYFNDDHGKLAGEITFPAINNDQTWVIEHTFVRDDFGHQGIAGQLTKAVIDAARVEHKRIQPLCTYAKAYFDRHPEAADVLVTSSQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULE1</accession>
    <name>F9ULE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate oxidase</fullName>
            <ecNumber evidence="6">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pox4</name>
        <name evidence="6" type="ordered locus">lp_3587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102235.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891062.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3587"/>
    <dbReference type="EnsemblBacteria" id="CCC80548">
        <property type="protein sequence ID" value="CCC80548"/>
        <property type="gene ID" value="lp_3587"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3587"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2992"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_9"/>
    <dbReference type="OMA" id="EFGQWAQ"/>
    <dbReference type="PhylomeDB" id="F9ULE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3035-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="196"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="384"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="584" mass="63795" checksum="9949A2AC35F11ECC" modified="2011-10-19" version="1">MEMTKIKAGQALAQVLVDWNIDHIYGITADSINNTVDGFYQEKDHLKYIQVRHEEVGALAAAADAKLTGTIGVSFGSAGPGAVHLLNGLYDAKMDHVPVLALVGQSATSIMNTNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRSVSVVIIPDDLSGQDIKFDGFKTASLSGSQQVLMPKLDDVQQTIAALKAAQHPVLWIGKGAYNARQEVIAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVLFVGTNFPFARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPTKFLKAAQRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAIRQLPLNKQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEVKYHLPVINVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKELKATFQKVTQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIAEADQPALSQLLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULG6</accession>
    <name>F9ULG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, medium chain dehydrogenase/reductase family (MDR)</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102254.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891087.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3614"/>
    <dbReference type="EnsemblBacteria" id="CCC80573">
        <property type="protein sequence ID" value="CCC80573"/>
        <property type="gene ID" value="lp_3614"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3614"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3016"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="FHEYGAP"/>
    <dbReference type="PhylomeDB" id="F9ULG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3060-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="33416" checksum="72E918743D7A7DFA" modified="2011-10-19" version="1">MKAFGFNQYGNSNVMEELNIPIPKIKPGEVLVKTTAFAINAFDIAVRNGQFRNNVTLLFPTILGTDGVGRIVKLGAGVHDYSIGDDVLARPGIGTYTEYFKVSVDHLGSRPSNYSPYEAAGLPLSGITAYNTLVHIAHVKQGQTVVILGSSGGVGSMLVQMAHALGLYVIGTDAESARETVLNLGASEFGAYDTERVSSKFKSMADILIDATNLGASIAGIQIIKPTGTYVSLTTLPKDRTLKPDVIYRQVIPRREYRDSDAFTTISLMIRNNQLHVPIDHLESFTLDGIRKGQSDVENGSPDGKVIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH4</accession>
    <name>F9ULH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sorbitol-6-phosphate 2-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.140</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srlD1</name>
        <name evidence="2" type="ordered locus">lp_3623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.140" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891095.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3623"/>
    <dbReference type="EnsemblBacteria" id="CCC80581">
        <property type="protein sequence ID" value="CCC80581"/>
        <property type="gene ID" value="lp_3623"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3623"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3025"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_9"/>
    <dbReference type="OMA" id="LASKICY"/>
    <dbReference type="PhylomeDB" id="F9ULH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3068-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009010">
        <property type="term" value="F:sorbitol-6-phosphate 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="28832" checksum="672A53DEE65FF001" modified="2011-10-19" version="1">MTTDWLGLKDKIVLVTGGSSGIGDAIVESLLNNGAKVVDLDLHSSSRKNQHFDFVECDVSSEEAVTEAIDQILDKFGRIDGLVNNAGINLPRLLVDEQMPRGQYELCTEVFNKMFAVNVRSTFLMSQTVGRQMVKQRSGTIVNMSSEAGLEGSQGQSVYAATKGAINGLTRSWSKELGVFNIRVVGVAPGIMDATGLRTPSYEEALAYSRHQTVQQLRSGYTSKSTTPLGRSGHLYEVADLVSYLLSERASYITGITVNVAGGKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH8</accession>
    <name>F9ULH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bgl</name>
        <name evidence="3" type="ordered locus">lp_3629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="4">
        <citation type="journal article" date="2017" name="Biochim. Biophys. Acta" volume="1865" first="1227" last="1236">
            <title>Structural basis of the substrate specificity and instability in solution of a glycosidase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Acebron I."/>
                <person name="Plaza-Vinuesa L."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
                <person name="Cumella J."/>
                <person name="Sanchez-Sancho F."/>
                <person name="Mancheno J.M."/>
            </authorList>
            <dbReference type="PubMed" id="28734976"/>
            <dbReference type="DOI" id="10.1016/j.bbapap.2017.07.007"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102266.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="5NAQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.48 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-461"/>
    </dbReference>
    <dbReference type="PDB" id="5NAV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-461"/>
    </dbReference>
    <dbReference type="PDBsum" id="5NAQ"/>
    <dbReference type="PDBsum" id="5NAV"/>
    <dbReference type="SMR" id="F9ULH8"/>
    <dbReference type="STRING" id="220668.lp_3629"/>
    <dbReference type="EnsemblBacteria" id="CCC80585">
        <property type="protein sequence ID" value="CCC80585"/>
        <property type="gene ID" value="lp_3629"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3629"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3029"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9ULH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3072-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5NAQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5NAV"/>
        </source>
    </evidence>
    <sequence length="461" mass="52701" checksum="14FE5B31459B4816" modified="2011-10-19" version="1">MVEFPEGFVWGAATSGPQTEGNFHKQHQNVFDYWFATEPEQFDAGVGPDTASNFYNDYDHDLALMAQAGVQGLRTSIQWTRLIDDFETASLNADGVAFYNHVIDSMLAHHITPYINLHHFDLPVALYDKYHGWESKHVVELFVKFAEQCFKLFGDRVDHWYTFNEPKVVVDGQYLYGWHYPQVINGPKAVQVAYNMNLASAKTVARFHELCVRPEQQIGIILNLTPAYAASDDPADLAAAEFAELWSNNLFLDPAVLGHFPEKLVERLTMDGVLWDATPTELAIIAANPVDCLGVNYYHPFRVQRPDISPKSLQPWMPDIYFKEYDMPGRMMNVDRGWEIYPQAMTDIARNIQKNYGNIPWMISENGMGVAGEERFLDKQGVVQDDYRIDFMKEHLTALAKGIAAGSNCQGYFVWSGIDCWSWNHAYHNRYGLIRNDIHTQTKTLKKSAKWFAELGERNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR0</accession>
    <name>F9ULR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888663.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0672"/>
    <dbReference type="EnsemblBacteria" id="CCC78149">
        <property type="protein sequence ID" value="CCC78149"/>
        <property type="gene ID" value="lp_0672"/>
    </dbReference>
    <dbReference type="GeneID" id="57025304"/>
    <dbReference type="KEGG" id="lpl:lp_0672"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.564"/>
    <dbReference type="HOGENOM" id="CLU_2617609_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-583-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="78" mass="9282" checksum="37AC50349E21D87C" modified="2011-10-19" version="1">MLNQQREQMHARLMPQATYGVELNQPLDEVVERSDEQITNEINKLTDFRTVEERQPDTPQMTMYRKLMEAKADREEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV1</accession>
    <name>F9ULV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotein endopeptidase, M22 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gpp</name>
        <name evidence="2" type="ordered locus">lp_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888704.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0717"/>
    <dbReference type="EnsemblBacteria" id="CCC78190">
        <property type="protein sequence ID" value="CCC78190"/>
        <property type="gene ID" value="lp_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="57024425"/>
    <dbReference type="KEGG" id="lpl:lp_0717"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.603"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_064886_0_1_9"/>
    <dbReference type="OMA" id="PFYLKDF"/>
    <dbReference type="PhylomeDB" id="F9ULV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-625-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="26172" checksum="85506D4DC235C519" modified="2011-10-19" version="1">MKLLAIDTSNRPLSVAVLEDTQILATTTTNVGRNHSSTLLPIIEQAMAQAKLAPADLDRIVVAAGPGSYTGLRIGVTTAKTLAFTLDKALVGVSSLAVLAGNIVTEGQLVAPLFDARRDNIFAGLYRIKNQRPVAVIADQHISVTEWGQRLASYDEPITFVGADVDQYADALQQSLAKQFVRAAPQLDLPQAVVLGLMGRTLTPVSEIHNFVPNYLRLTQAERDWQAKHPEKEHAPYVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW1</accession>
    <name>F9ULW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-phosphate N-acetyl-glucosaminyl transferase</fullName>
            <ecNumber evidence="8">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tagO</name>
        <name evidence="8" type="ordered locus">lp_0730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888714.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0730"/>
    <dbReference type="EnsemblBacteria" id="CCC78200">
        <property type="protein sequence ID" value="CCC78200"/>
        <property type="gene ID" value="lp_0730"/>
    </dbReference>
    <dbReference type="GeneID" id="57024435"/>
    <dbReference type="GeneID" id="66448703"/>
    <dbReference type="KEGG" id="lpl:lp_0730"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.615"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_2_4_9"/>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="PhylomeDB" id="F9ULW1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-635-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="365" mass="40375" checksum="A649F1320359A16D" modified="2011-10-19" version="1">MIRFEILVSLVATMILSAILTPFVRKLAFKIGAVDKPNVRRVNKIPMPTMGGLAIFISYTVGTTVLYLMHQFPSRIFFALLGGELIIIATGVIDDIYELKPRQKMLGITLAALEVYFIGGIRMTTFTFPLLGLIHFQWLSLPVTLLWILAITNAVNLIDGLDGLATGVSIISLSTMGIIGLFFLNANMFVSLLIFTLVAAMIGFLPYNFFPARIYLGDTGSLFIGFMTAVFSLFGLKNVTLISVGIPVMILGVPITDTVYAMIRRILNKKPISQADKHHLHHRLMQLGLTHRQTVMVIYGIALIFSFISLLYPISSIWGSVLLTIGLLFGLELFVEAIGLAGDNRQPLLDWIKRTVARLTSKSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX0</accession>
    <name>F9ULX0_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888723.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0742"/>
    <dbReference type="DNASU" id="1063506"/>
    <dbReference type="EnsemblBacteria" id="CCC78209">
        <property type="protein sequence ID" value="CCC78209"/>
        <property type="gene ID" value="lp_0742"/>
    </dbReference>
    <dbReference type="GeneID" id="57024443"/>
    <dbReference type="KEGG" id="lpl:lp_0742"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.624"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051142_1_0_9"/>
    <dbReference type="OMA" id="EHHELGI"/>
    <dbReference type="PhylomeDB" id="F9ULX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-644-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="44022" checksum="2BF299CC0694B83F" modified="2011-10-19" version="1">MQVLKIFELFLLQPLVWLGLLRSYLTAKRRVKSERQHFQSAINPQLVEVHHFLVDGCLLGVLMTIISLALGLVVAPIWVVIYEVVAAISLIIIPGALVPVTAFGLSWLVYWIMSPELTTVGGALQRHGVAMTSMSGNLVVNGLLLLAIVLAATAVLLRHYDYEGRSPQLQPDQRGKRLVRYQWQQLLVLPVGVLVPGDWLHATISWWPVFMVGERSFSILLLPLLVGTSVRVYKQLPQIAWRQLAARYGWVTLASVLVAIIARFAVLSPQWLLALMGLIVVLTWGILAQHRYHDRHQQFRYSDTEQGVRVIGLRPHTPADKLNLDLGDIILECNRQPVNTEAEFYAALLKSPTYVHLKVRNRQQELIITETAIYNGAPHELGIVLFTDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM56</accession>
    <name>F9UM56_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppx2</name>
        <name evidence="5" type="ordered locus">lp_0841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21528"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GppA/Ppx family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888809.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0841"/>
    <dbReference type="EnsemblBacteria" id="CCC78295">
        <property type="protein sequence ID" value="CCC78295"/>
        <property type="gene ID" value="lp_0841"/>
    </dbReference>
    <dbReference type="GeneID" id="57024537"/>
    <dbReference type="KEGG" id="lpl:lp_0841"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.715"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_0_9"/>
    <dbReference type="OMA" id="IGCVRMT"/>
    <dbReference type="PhylomeDB" id="F9UM56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-731-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006793">
        <property type="term" value="P:phosphorus metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022371">
        <property type="entry name" value="Exopolyphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03706">
        <property type="entry name" value="exo_poly_only"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="4">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="317" mass="34744" checksum="0016B181C98F74E3" modified="2011-10-19" version="1">MENFAVIDLGSNSCRMTITQIQEDGSYAVTHRLKEMVRLSENENATDTPTLQAEAIDRTIAALKSFAAVYKDLPNLTIKAVATAATRKASNQKKFLKRVKNDVGLDIEVIPGTTEAYYDYLGVVNTLPTTNCVMVDTGGGSCELVLIVNGQAKDLISLPIGAVSLSEKFGLNDQVTASQLFKTMTFVDKIFNSVWWLRNGLNLPLVCLGGSNRTLAKINRRKCNILNFEDIHGYRLRDNAIYDTFNTVISQDAAGRAAIPGLAKDRADIIVGGMIPAISLMRFLDSDRMIFSQNGLREGILFEHLTALAEQSAKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM94</accession>
    <name>F9UM94_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888847.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0891"/>
    <dbReference type="EnsemblBacteria" id="CCC78333">
        <property type="protein sequence ID" value="CCC78333"/>
        <property type="gene ID" value="lp_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0891"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.754"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040170_0_0_9"/>
    <dbReference type="OMA" id="LPVMMLD"/>
    <dbReference type="PhylomeDB" id="F9UM94"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-769-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="31248" checksum="6CF9FFF141A8CE3D" modified="2011-10-19" version="1">MMVIAIVVLLMLLSIGLFGLLLAGARRQAAPFFDHSFGFGMVIGAVTDFLDTLGIGSFVVSTAIFQASHYLKDERKLPGTLNTMHAIPTAFEAFFFVTAVAVEPVTLISLVLAATLGALLGSEVMTKLNQRWIQLIMAGALVITALLMAAKLLGWISLLGVANQATGLSGWKLLVGIGGNFILGLLMSAGVGLYAPCMVMVYFLGLTPIAAFPIMMLSCALLMPISAVNFIRHDRVDYRGLFGIILGGIIGVVVAATLVKSLSLTALSWLIVLVSCWTAFSLWRAAQRRKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA0</accession>
    <name>F9UMA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphohydrolase, MutT/nudix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101193.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0897"/>
    <dbReference type="EnsemblBacteria" id="CCC78339">
        <property type="protein sequence ID" value="CCC78339"/>
        <property type="gene ID" value="lp_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0897"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.760"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_0_9"/>
    <dbReference type="OMA" id="RRQFNVC"/>
    <dbReference type="PhylomeDB" id="F9UMA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-775-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="145" mass="15768" checksum="17097CCBEB48F003" modified="2011-10-19" version="1">MGYVLDLRRQVGHQPLVVAGAALMAQNSIGKIVLIYRTDNHCWGLPAGSTEPGETVQQTARRELKEETGLTVGELTLIDVYSGPKMHYQYPNGDIIDSVTTLYRANTTGGELIQATDETSTAAFFALDALPTPLTPLTKWMLCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG6</accession>
    <name>F9UMG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0972"/>
    <dbReference type="EnsemblBacteria" id="CCC78405">
        <property type="protein sequence ID" value="CCC78405"/>
        <property type="gene ID" value="lp_0972"/>
    </dbReference>
    <dbReference type="GeneID" id="57024646"/>
    <dbReference type="KEGG" id="lpl:lp_0972"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.828"/>
    <dbReference type="eggNOG" id="ENOG5030A1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316768_0_0_9"/>
    <dbReference type="OMA" id="EATFFGQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-841-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0079">Bacteriocin immunity</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12539" checksum="96998D2395AE89AB" modified="2011-10-19" version="1">MLYSWHGGINVNKNDKAKRLMQQIDVAYNDPEVKQDAQVRADLLRYAMELDKNGNYLLIATKVNGMAMRVMRDHMHQPLQAINTLYTQTARTSEYYWGVAAASIFSGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH3</accession>
    <name>F9UMH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnF</name>
        <name evidence="9" type="ordered locus">lp_0982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78412">
        <property type="protein sequence ID" value="CCC78412"/>
        <property type="gene ID" value="lp_0982"/>
    </dbReference>
    <dbReference type="GeneID" id="57024653"/>
    <dbReference type="KEGG" id="lpl:lp_0982"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.835"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_3_0_9"/>
    <dbReference type="OMA" id="FIVLFME"/>
    <dbReference type="PhylomeDB" id="F9UMH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-848-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="233" mass="25292" checksum="CF5D50077B57B3B3" modified="2011-10-19" version="1">MDSSLTFRAGIKDVIPTVFGYIGVGLAMGIVANTSHLSVWAVLLMSLIVYAGSAQFIIVSMLLAGSPISAIVLSTFLINSRMILMSMSVAQYFKKESLLQNIGLGSLLTDETFALSMNKLNQTNQQLKTSWLHAANIVAYLVWAAATVVGCLLGNLITDPNQFGLDFAVVGMFIGLLYLQIITDRSKSLPTQLWVVLFVALAMYFLMRWVPGNLALIFATLLGCGFGMVVDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMP7</accession>
    <name>F9UMP7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1081"/>
    <dbReference type="EnsemblBacteria" id="CCC78486">
        <property type="protein sequence ID" value="CCC78486"/>
        <property type="gene ID" value="lp_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1081"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.915"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055794_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-929-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="318" mass="35717" checksum="1626913E911C361F" modified="2011-10-19" version="1">MHRYTYHFYTGLITGLLIWVHPLGGLASRVRPTLPYPPTTLQRTATQAVFSPTEFYQTIRQYPDLVKLAKFDPIGMLQGTTIQPGLQATLTRDLVTKQLTTTTMMIPQGVVIAGRYRLTTAYDATGRTQSVLYVQDRFRHQLCNTVLLHGKPHVGGLAYDPHHQRIWLCSHRHGHGAIVSVSLAALRHFDPTTSIAVHYQQRWSLPTLSNASLLTYHHQALYVGQFKPGQTTLVARYPLTSAGTPYRMTTSHAILPKAVSDWHGKLPPNIQGMAFYDHYVLLSQSYGPSASHLLLFKRSQLIQQHQLTTGIAILRLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ9</accession>
    <name>F9UMQ9_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Manganese ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="5" type="ordered locus">lp_1095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889012.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1095"/>
    <dbReference type="EnsemblBacteria" id="CCC78498">
        <property type="protein sequence ID" value="CCC78498"/>
        <property type="gene ID" value="lp_1095"/>
    </dbReference>
    <dbReference type="GeneID" id="57024744"/>
    <dbReference type="GeneID" id="66448998"/>
    <dbReference type="KEGG" id="lpl:lp_1095"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.927"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_9"/>
    <dbReference type="PhylomeDB" id="F9UMQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-941-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="245" mass="27245" checksum="1EB3F61E16DC6200" modified="2011-10-19" version="1">MLKVQNLTVAYSDTPVFTDVAVNFNAGKITGIIGPNGAGKSTMIKAMLGLIKSQTGTVEYEGRALKQFQKQIAYVEQRKDLDLTFPINVFDVVLTGTYGKLGLFREPSKADRQRCQDALEQLELADLAQRQISQLSGGQLQRVFVARALVQEADIIILDEPFVGIDLQSETAIMTILHQWRDAGKMIIVVHHDLNKVSRYFDDLVILNHGIVDYGPVDAVYTPANIERTFSADLSAVLFTKEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR0</accession>
    <name>F9UMR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtsB</name>
        <name evidence="8" type="ordered locus">lp_1096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101257.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889013.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC78499">
        <property type="protein sequence ID" value="CCC78499"/>
        <property type="gene ID" value="lp_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1096"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.928"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_9"/>
    <dbReference type="OMA" id="GAWLSYY"/>
    <dbReference type="PhylomeDB" id="F9UMR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-942-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="30715" checksum="A84193BADBA8F8E8" modified="2011-10-19" version="1">MQSITTFMAALGKYDFLQSALITAIMVGVMSGIIGSFIILRGMSMMGDAISHAVLPGVAVAYMLGINVLIGASVFGILAASLIGFVASRSKIKTDTSIGIVFSAFYALGFILISLAESSTNLHHILFGNILAVSDTDMMTTTVVLGLVILFVAFFYKELLITSFDPTFAKTYGLKVQLLHYALMLVLTLVTVSALQTVGIILVVAMLITPAATAFLWTERLAVMLGLSALIGVLSSVVGLYLSYTLNWASGPAIVLVAAIFFGISFIISPKQALLPTLWKGQAAARRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX9</accession>
    <name>F9UMX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase/acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps1E</name>
        <name evidence="3" type="ordered locus">lp_1181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889082.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1181"/>
    <dbReference type="EnsemblBacteria" id="CCC78568">
        <property type="protein sequence ID" value="CCC78568"/>
        <property type="gene ID" value="lp_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1181"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.999"/>
    <dbReference type="eggNOG" id="COG4763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023915_6_0_9"/>
    <dbReference type="OMA" id="GYLWYLY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1011-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="334" mass="38215" checksum="C2DC114A04FFEFFE" modified="2011-10-19" version="1">MNKGRIVWIDIAKGIGIILVVYGHALGGIMNSNGIGVHNSLTIPYNIIYGFHMPLFFFLAGMFVHNWAKRPLKVALSQKLRSLVIPYFVWTIITGSVMALVRKYTNSGLGVKDILLSPIAPFSEYWFLYVLFVIFVIYYVMIRLVNDKGLIVIAFLLFLMRPILYEYWIFDALSLNFLWFVLGAEFQKQKMLNSVMKYSTKKMWFSLIVFVVVNILNLIVLRLNVYWIGSYYKVLTVPAGIMFVIYISQLLEKYEVIEAILSWLGGASMAIYVMHLIPIAGCRIIALKLIRYQNLFALSIIITLIALIVCVSIYALIIKTVIGKVVFGKKLVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ5</accession>
    <name>F9UMZ5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein CpsC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cps2A</name>
        <name evidence="11" type="ordered locus">lp_1197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101298.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889098.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1197"/>
    <dbReference type="DNASU" id="1063113"/>
    <dbReference type="EnsemblBacteria" id="CCC78584">
        <property type="protein sequence ID" value="CCC78584"/>
        <property type="gene ID" value="lp_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1197"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1015"/>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082668_1_0_9"/>
    <dbReference type="OMA" id="NIQMANT"/>
    <dbReference type="PhylomeDB" id="F9UMZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1027-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="9">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="10">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="28184" checksum="FE8E1FD3B8149B0E" modified="2011-10-19" version="1">MMDQAVSFDFFIRLVRKYWRAIVSFTVVGLIVAAGLTFFVITPKYQSSVQILVNRKNTNAATEYAGQQADVQMITTYKELIAGQVVLKPAKQQLSKRYGIERSLNTLKSEVSVTSTTNSQVFSIAVTDADAKASATIANQIARSFKNQVQKIIKVNNVTIVAPAETPNGAVSPKKPLNMLIGLVVGLLLGIVYAAIRMLTDRRVHDADFLTDELGLTSLGLVNHQHHHSMKKQALNLNGGYHTHNDRTSSQAMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ7</accession>
    <name>F9UMZ7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cps2C</name>
        <name evidence="4" type="ordered locus">lp_1199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101300.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1199"/>
    <dbReference type="DNASU" id="1063109"/>
    <dbReference type="EnsemblBacteria" id="CCC78586">
        <property type="protein sequence ID" value="CCC78586"/>
        <property type="gene ID" value="lp_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1199"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1017"/>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_0_9"/>
    <dbReference type="OMA" id="VHPERNS"/>
    <dbReference type="PhylomeDB" id="F9UMZ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1029-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="257" mass="28826" checksum="4E7C0E6163C4F649" modified="2011-10-19" version="1">MKINNLVDLHCHILPAIDDGSPSLEASLELARQAVADGIRYILATPHHMDRHYLNHAGDVVAAVEAFQAELDVNDIPLTIFPGQEVHLNGQLMEKVDDLLSIDTGRHYLLLELPHEMVPSYLDEMIFQLSCEGITPVIAHPERNAQIIAEPQRLYKLAEDGVLAQVTATSLVGTFGEQVQRTAKEFVKCGLVQVVASDAHTLKNRGFAMTKAYQVLNEMDSKYPERFATNARDLLNGEQIEMGQIEIPRKQRKHWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN10</accession>
    <name>F9UN10_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1213"/>
    <dbReference type="EnsemblBacteria" id="CCC78599">
        <property type="protein sequence ID" value="CCC78599"/>
        <property type="gene ID" value="lp_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1213"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1030"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_17_3_9"/>
    <dbReference type="PhylomeDB" id="F9UN10"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1041-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="11042" checksum="33F8C35ACCE35196" modified="2011-10-19" version="1">MDYSRAMNKCNVSYGQVYSWTRKFKQGGPEALVDRRGKGKTVHDQLTDNEKRDLEVKRLKARIEHLSTENAVLKKLQELERLDATHHTSTKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN29</accession>
    <name>F9UN29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101327.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889132.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1236"/>
    <dbReference type="EnsemblBacteria" id="CCC78618">
        <property type="protein sequence ID" value="CCC78618"/>
        <property type="gene ID" value="lp_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1236"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1048"/>
    <dbReference type="eggNOG" id="ENOG5030A9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203178_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1059-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="70" mass="7806" checksum="CB595E949684639B" modified="2011-10-19" version="1">MTKTWLKATLTVQTTTELDEQRKQTFNAIAQDATDEQLAAFGKIVEVLTGDQFTAVNLANAYRYDPQPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN86</accession>
    <name>F9UN86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="678" mass="75875" checksum="66DE526650F18763" modified="2011-10-19" version="1">MKAVVKSVNWLAAAVLVVAVGMAWLQPIHFFGNPDWASPVVQLAMVLGLLVMTMAGRQVLKQLSSRQYRWLLIGLVGLIAIVQILIATSFVDVARADPFFVRQQALLLARGSHHWQHYFMIYPNNVNFTLLVANLLKPLLKLTQTPWVLLNVIRFIWIDTGLISGLYLLNRWRYWQPGAVSFSLLWLVSVPVAAFGLFAYTDALVLPLLPDSLALLTLGLSLTGWRRWGVLIGDGLLVAVGVVMKTNLIVLWLTLVLMGIILWWQRQFSGRQMLGWLVSLVMTLGVMFAVMRTAQQQAGYTRQADAALPATSWIAMSLNPQSSGEYRHGDFARVNQMPTAAAKRQQTQQMIQQRLHQMGVTGTLVHLLKKMRVFWATGDFDSFKLTTQWIRAPRWYLNHQRQLQFWLVLMTQTIYLTMLVQAIVTLMRRREWAVTFVALAILGLTAFHVGLWEVEGRYALPLLPGLMLLSIVGGRELPVWHLNRVMRRQLTWLVVVLAAISVVSLWQTSRATRITDVVRGNQGNGRYVVSTVQKIRPGQAVTTPLAVSGKSNVLRLKPVATHGRVTITLTKETHVVKRWRGSANELTTLNYPLTAAGNLRLAIKNIGQTPVRYGVMAANYSPLTGRVTAKRHAYLQVVIKQQFIKPHALTTGAASLAVVGCVALATILALGRLRPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI1</accession>
    <name>F9UNI1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="12">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ribA</name>
        <name evidence="14" type="ordered locus">lp_1437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101406.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889284.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1437"/>
    <dbReference type="EnsemblBacteria" id="CCC78770">
        <property type="protein sequence ID" value="CCC78770"/>
        <property type="gene ID" value="lp_1437"/>
    </dbReference>
    <dbReference type="GeneID" id="57025071"/>
    <dbReference type="KEGG" id="lpl:lp_1437"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1203"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_9"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="PhylomeDB" id="F9UNI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1231-MON"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="211"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="404" mass="43615" checksum="54F547E67C7BA20F" modified="2011-10-19" version="1">MDTMKKVAAALAALKRGELIIVADDETREAEGDMVGLAAKATTATVNRMITSARGLLCVPMAPSIATRLHLTPMTSEHDAFGTAFTVSTDHHTTSTGISAADRATTIQALANPNSQAADFYHPGHVFPLIARTGGLLARRGHTEAAVTLAQLAGVTPAAYICEVIKKNGLMARRRDLKALAEGLQLPLITIEDITTYVIQTGAAQLTTTPSVNLPTKDGQFTMTGFEVPGHTALPVALQAGDISGDEPVLVRLHSECFTGDVLGSRRCDCGDQLHAALQKISQAQRGVFVYLRQEGRGIGLANKLAAYALQEHGVDTYDANVQLGFQPDERRYDIAALVLRQMGITRVRLLTNNPDKVEQLRAAGIDVVERVPLEIPANQYDQAYLKTKRDRFHHQLTLTEGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL3</accession>
    <name>F9UNL3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron chelatin ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fecB</name>
        <name evidence="3" type="ordered locus">lp_1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101420.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889316.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1473"/>
    <dbReference type="DNASU" id="1062340"/>
    <dbReference type="EnsemblBacteria" id="CCC78802">
        <property type="protein sequence ID" value="CCC78802"/>
        <property type="gene ID" value="lp_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1473"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1236"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_13_2_9"/>
    <dbReference type="OMA" id="PAMFNTW"/>
    <dbReference type="PhylomeDB" id="F9UNL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1263-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389024" evidence="1">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="356" mass="38587" checksum="92B6D607715602D8" modified="2011-10-19" version="1">MKKTRRILLGLALIIGLSVGAGCRSTASKSKTANASQSATTRTVTDMAGTKVKIPTKVTRVADLWHANNQVVLLLGGQKKLVATTQMIKQSPWFKTIDPGISRVTAPFAGDDLQTEELLKAKPDVVIAADTAQVKQARKAKIPTINAMYQTFAGLRQSVNLTAQVLGGTAPKIAKAYQKTLTTNLNDVKNRLKDVTFKPKVLHFVNATNLNQVDGTGTIVNEWIKAAGGQNALKQKGNMISVTTETLAKSDPDVIIVGSATTAEARAALKKNAVLSKLTAVKKNRVYGNPQGTFPWDRYSAEEALQVLWAAKKLHPDQFQDLNMVAKTKAFYQQFYHYQLSTAQANRLLNGASSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL7</accession>
    <name>F9UNL7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaE</name>
        <name evidence="1" type="ordered locus">lp_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889320.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1478"/>
    <dbReference type="EnsemblBacteria" id="CCC78806">
        <property type="protein sequence ID" value="CCC78806"/>
        <property type="gene ID" value="lp_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1478"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1240"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_2_9"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="PhylomeDB" id="F9UNL7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1267-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="133" mass="14851" checksum="6B53D5AC51D6AC18" modified="2011-10-19" version="1">MAMIKLSATPLDVNALYQVLKAPEYGGIVTFVGTVRQWTGPIETQSIDYSAYAEMAISQLNKLAAPIEAKGARVVIVHRIGHLDLMDEAVFVGVAAAHRAEAFEWCQYLIDTLKKEVPIWKKEFDTDKVRWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNQ7</accession>
    <name>F9UNQ7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101455.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1521"/>
    <dbReference type="DNASU" id="1061207"/>
    <dbReference type="EnsemblBacteria" id="CCC78846">
        <property type="protein sequence ID" value="CCC78846"/>
        <property type="gene ID" value="lp_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1521"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1280"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_0_9"/>
    <dbReference type="OMA" id="QGTYSEY"/>
    <dbReference type="PhylomeDB" id="F9UNQ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1307-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="16"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="343" mass="37659" checksum="F3899119D695FC65" modified="2011-10-19" version="1">MHAIGFTDHLPIEDPASLRDVTISKPSAQGHDLLVQVQAVAVNPVDVSVRKTGHEHRMRPKILGWDATGIVTAVGEAVTLFQPGDHVFYAGSFRRPGCDSAYHLVDERLVGHAPATLTTAARAAMPLTSLTAYEALFEQLHIPFDPAKPNSEKCNQTILIINGAGGVGSIATQLAKLAGLTVISSASRPESIAWTQQHGADLVVNHHHDLVSEVHALGIKDVDYILGLSDLDSHWNEICTLIKPGGHIASITENRRPIDLKKLTKKRGTFAWEWMYSKSYYHTADMISQHDILETIADLLDRGLLQSTLSQTLRPINALNLRQAHQLIEQHHMIGKVVIEGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR4</accession>
    <name>F9UNR4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein, YhbY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889367.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1529"/>
    <dbReference type="EnsemblBacteria" id="CCC78853">
        <property type="protein sequence ID" value="CCC78853"/>
        <property type="gene ID" value="lp_1529"/>
    </dbReference>
    <dbReference type="GeneID" id="57025124"/>
    <dbReference type="GeneID" id="66449420"/>
    <dbReference type="KEGG" id="lpl:lp_1529"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1287"/>
    <dbReference type="eggNOG" id="COG1534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_1_2_9"/>
    <dbReference type="OMA" id="FQVGKNG"/>
    <dbReference type="PhylomeDB" id="F9UNR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1314-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11715" checksum="494BB9E70C2ABD8F" modified="2011-10-19" version="1">MENLRGKQKHYLRGEAHHMRPLFAVGKNGLTDEWLTQLTGALDKRELIKVNILQNADVTTAEVKAAIEQKTAITVVQTIGRVLVLYLPASHEEDQHYSLEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU9</accession>
    <name>F9UNU9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fthC</name>
        <name evidence="5" type="ordered locus">lp_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640322.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889402.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1570"/>
    <dbReference type="EnsemblBacteria" id="CCC78888">
        <property type="protein sequence ID" value="CCC78888"/>
        <property type="gene ID" value="lp_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1570"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1322"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_2_9"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="PhylomeDB" id="F9UNU9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1349-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="21442" checksum="6D1B733D53C5352A" modified="2011-10-19" version="1">MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPLIEQAWAEGKMVVIPKTLPHRQMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVPGLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAFEHAEWPVDQYDVLLDELLVAGDEQHDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ5</accession>
    <name>F9UNZ5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">lp_1621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889448.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1621"/>
    <dbReference type="EnsemblBacteria" id="CCC78934">
        <property type="protein sequence ID" value="CCC78934"/>
        <property type="gene ID" value="lp_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1621"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1369"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_9"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="PhylomeDB" id="F9UNZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1396-MON"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="23393" checksum="56D6CA4C58D74B36" modified="2011-10-19" version="1">MIKVAPSILSADFANLQRDVQMAENAGADALHIDVMDGQFVPNLSFGMSTVADLRPVTSLMLDCHLMIMDPERFVGQFAKAGADLIGVHVESTRHIYHALQLIKDAGVKAEVVVNPGTPLSMISELLPLVDQVLIMTVNPGFGGQHFLDQMVAKIAALNELKQQHGYRFEIEVDGGINDQTVKACYDAGATVAVAGSYVYDSADPAQRIQDLKVATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP64</accession>
    <name>F9UP64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding protein, universal stress protein UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644345.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889517.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1701"/>
    <dbReference type="DNASU" id="1062233"/>
    <dbReference type="EnsemblBacteria" id="CCC79003">
        <property type="protein sequence ID" value="CCC79003"/>
        <property type="gene ID" value="lp_1701"/>
    </dbReference>
    <dbReference type="GeneID" id="66449568"/>
    <dbReference type="KEGG" id="lpl:lp_1701"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1437"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="PRQEIHQ"/>
    <dbReference type="PhylomeDB" id="F9UP64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1466-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="16375" checksum="2E72FCE1A4B091BD" modified="2011-10-19" version="1">MYQNILVPLDGSDNAYMALKHAVKLAQTFKSKLFLVNVIDITRLNAYSPAAYGGTLYTNLLKVAKDNSQDILDRGQQMASAAQVESLPIQVNSSPKASIATDIPKKYAIDLIVMGKSGTNAVSRILLGSTTAYVVQKAEVNVTVINTIDDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP82</accession>
    <name>F9UP82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA methylase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889535.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1724"/>
    <dbReference type="EnsemblBacteria" id="CCC79021">
        <property type="protein sequence ID" value="CCC79021"/>
        <property type="gene ID" value="lp_1724"/>
    </dbReference>
    <dbReference type="GeneID" id="57025350"/>
    <dbReference type="KEGG" id="lpl:lp_1724"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1456"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_6_1_9"/>
    <dbReference type="OMA" id="PWCAEGF"/>
    <dbReference type="PhylomeDB" id="F9UP82"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1484-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031340">
        <property type="entry name" value="RsmF_methylt_CI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17126">
        <property type="entry name" value="RsmF_methylt_CI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="103"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="455" mass="50302" checksum="AF84D228AAE6E9AB" modified="2011-10-19" version="1">MQLPAEFIQKYQRLLGDQAPAFLAAFDGPVEKGFRINPNKTVTATMRAKMTAPVPYSPIGYYGKVNGNALEHLAGAVYSQEPSAMTVGEFAKPEPGERVLDLCAAPGGKTTHLLSYLHQTGLLVTNEINRQRVTALGDNVERYGARNTVITNDTPAALAKELPGFFDRILVDAPCSGEGMFRKDHDAVQYWTPDYPAACAERQREILTEAVKMLRPGGHLIYSTCTFAPEEDEQMMAWLLKTYPEFELEPLAKTAGMVDAKPEWADGNPELAKAARLFPHLMRGEGHFIAKLVYHGTTVGKDKKVVREQLNATQRQLWTDFLKKQAMAGLPQLVLQAHGDQLYGVPAMMPVTRKLKVFRPGILLGTFKKKRFEPSYALALASDDLSLPKTEITREQWALYVHGETFELTSAPVAGFRVLTCDGLPVGFGKIVAKTVKNFFPKGLRFLATSENATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP84</accession>
    <name>F9UP84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate (Maltose)/proton symporttransporter, GPH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malT</name>
        <name evidence="3" type="ordered locus">lp_1729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644357.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889537.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1729"/>
    <dbReference type="EnsemblBacteria" id="CCC79023">
        <property type="protein sequence ID" value="CCC79023"/>
        <property type="gene ID" value="lp_1729"/>
    </dbReference>
    <dbReference type="GeneID" id="57025352"/>
    <dbReference type="KEGG" id="lpl:lp_1729"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1458"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030246_0_0_9"/>
    <dbReference type="OMA" id="FQWYALF"/>
    <dbReference type="PhylomeDB" id="F9UP84"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1486-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="48336" checksum="3AC9A1FABCA42933" modified="2011-10-19" version="1">MKETSKTTAGLPKLSSNKIWMMSLGFLGVQMAFTLQSSQMSRIFQTLGADPNNLGWFFILPPLAGLIVQPIIGSLSDRTWAPRLGGRRLPYLILGTVVAAIVMLLLPNSGSFGFGYASMAALVFGAITVAFLDLSSNVAMQPFKMMVGDMVNDDQKSYAYGIQSFLLNTGAVIAAIFPFLLTLFGVANTASKGVIPNSVIWSFYIGAAILVVSTIITIARVREYDPVTYAKYHGIDESANKSGGNWLALLKKAPKVFWLVALVQFFCWMAFQYLWTYSTGAMAANVWHTTNASSAGYQAAGNWYGILSAVQSVAAVVWSYVLAKVPNNRHKLGYALSLLLGAIGFFSIFFIHSQSALVVSFILVGMAWAAMNTYPLTMVTNALSGEHMGTYLGLFNGSICLPQIVASLLSFALYPLFGNSQANMFIFAGIVLAVGAGTVGLIKETYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC9</accession>
    <name>F9UPC9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD1</name>
        <name evidence="5" type="ordered locus">lp_1781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="lpl:lp_1781"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1502"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_9"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="PhylomeDB" id="F9UPC9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
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        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
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        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
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        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="307" mass="33868" checksum="0EBDB94A7ABE5AD8" modified="2011-10-19" version="1">MAGATTEQQFTITDQTGRLDKVLAALQSVWTRSQVDKLIKTDQVTVNGQLEASKYHVKPGDEIVVAAQTVQQTTIEPENIPLDIVYEDDDVLVVNKPQGMVVHPAPGHPNHTLVNALLYHSPLSTINGEFRPGIVHRIDKDTSGLLMVAKNDRAHQSLAAQLKAKTNLREYVALVHGVIKEDTGTINAPLGRSPKDRKKQAIVKTGRPAVTHFKVLKRYQHYTLISCRLETGRTHQIRVHLQSIGHPLVGDPLYGPKKTIKGHGQFLHAKLLGFKHPVTGDLLTFEAPLPPIFTTTLAKLDKTDGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD6</accession>
    <name>F9UPD6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645057.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889589.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1788"/>
    <dbReference type="DNASU" id="1061643"/>
    <dbReference type="EnsemblBacteria" id="CCC79075">
        <property type="protein sequence ID" value="CCC79075"/>
        <property type="gene ID" value="lp_1788"/>
    </dbReference>
    <dbReference type="GeneID" id="57025402"/>
    <dbReference type="GeneID" id="66449636"/>
    <dbReference type="KEGG" id="lpl:lp_1788"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1509"/>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146070_0_0_9"/>
    <dbReference type="OMA" id="QEWNEYG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1538-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="15019" checksum="EFEE94F341834BAE" modified="2011-10-19" version="1">MQPVEKHRLQQKYKLAPTYYGVIQITNERNHKIWIDTVPNLHNRWAFYQLNLNKNFYRSNPLQADWNQQTAADFSYQILWQKETTDVTNMRATLKALKTKWLHDLQPFDDHGYNRRPKDWKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI6</accession>
    <name>F9UPI6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644425.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889639.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1854"/>
    <dbReference type="EnsemblBacteria" id="CCC79125">
        <property type="protein sequence ID" value="CCC79125"/>
        <property type="gene ID" value="lp_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1854"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1562"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_0_9"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="PhylomeDB" id="F9UPI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1588-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="31783" checksum="7E7993E7070584D3" modified="2011-10-19" version="1">MANIQWYPGHMAKAIHQIQDNLHLVDIVFELVDARIPVASRNPEIEKTVQQKPHLLIMTKKDLADPQATADWVKYYEDQGQVAIAVDSRSRTIGKQMTQAASDMLADKLAKIAARGITNRPIRAVCVGIPNVGKSTLLNHIVNKKIAKVGDRPGVTKGQQWLKASNKLELLDTPGILWPKFEDQVVGTKLAVTGAIKENIYPNDDVALFALDFFKQHYAARLVDRYHLTAEQLTLPNPELLIAMTKNAGMRDDWERFCVAFLLDIRKGRLGRFTLDLTGDQPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPK7</accession>
    <name>F9UPK7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hbsU</name>
        <name evidence="6" type="ordered locus">lp_1879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1879"/>
    <dbReference type="EnsemblBacteria" id="CCC79146">
        <property type="protein sequence ID" value="CCC79146"/>
        <property type="gene ID" value="lp_1879"/>
    </dbReference>
    <dbReference type="GeneID" id="57025473"/>
    <dbReference type="GeneID" id="66449705"/>
    <dbReference type="KEGG" id="lpl:lp_1879"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1583"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_9"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="PhylomeDB" id="F9UPK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1608-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="91" mass="9621" checksum="ED150484E66AAAB0" modified="2011-10-19" version="1">MANKAELVNNVAAATNLTKKDATAAVDAVFASIQDTLAKGEKVQLIGFGNFEVRERAARKGRNPQTGDEIQIPASKVPAFKPGKALKDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ4</accession>
    <name>F9UPQ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactoside O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thgA2</name>
        <name evidence="5" type="ordered locus">lp_1933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.18" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640644.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1933"/>
    <dbReference type="EnsemblBacteria" id="CCC79193">
        <property type="protein sequence ID" value="CCC79193"/>
        <property type="gene ID" value="lp_1933"/>
    </dbReference>
    <dbReference type="GeneID" id="57025519"/>
    <dbReference type="KEGG" id="lpl:lp_1933"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1630"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_2_9"/>
    <dbReference type="OMA" id="WITAPYY"/>
    <dbReference type="PhylomeDB" id="F9UPQ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1655-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008870">
        <property type="term" value="F:galactoside O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="202" mass="22188" checksum="8C9BCF53D018A582" modified="2011-10-19" version="1">MMDERQRSLSGQTYDAHAPVFLELKRRTRQLLSQYNQLAYDQKSEKRTILQAMFAKIGSNVSVGSPFICDYGCNISIGQNVSINMNCTLIDCNRITIGNNVLIASNVQIYTATHPVELHERLRADWQPDSDQYFCQTLARPVTIEDGCWIGGGVIIIPGVTIGRGSVIGAGSVVVKDIPANSLAVGNPCRVIRQINQGEPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX5</accession>
    <name>F9UPX5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein DltD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dltD</name>
        <name evidence="2" type="ordered locus">lp_2016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; lipoteichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DltD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640704.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889778.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2016"/>
    <dbReference type="EnsemblBacteria" id="CCC79264">
        <property type="protein sequence ID" value="CCC79264"/>
        <property type="gene ID" value="lp_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2016"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1703"/>
    <dbReference type="eggNOG" id="COG3966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050505_0_0_9"/>
    <dbReference type="OMA" id="QMNWEEA"/>
    <dbReference type="PhylomeDB" id="F9UPX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1726-MON"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070395">
        <property type="term" value="P:lipoteichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006998">
        <property type="entry name" value="DltD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023896">
        <property type="entry name" value="LTA_DltD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40039">
        <property type="entry name" value="PTHR40039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04914">
        <property type="entry name" value="DltD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021438">
        <property type="entry name" value="DltD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04092">
        <property type="entry name" value="LTA_DltD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="425" mass="48664" checksum="361683B7B7296C21" modified="2011-10-19" version="1">MNVAKRLFKIFGPIILAAVLLLAVLLSPFSFGLNHISKDTEKKAAVSLSANVLKGRLVKRQALDDGYVPFFGSSEWSRFDPMHPSVLATKYHRNYRPFLLGARGTQSLTQYFAMQSVKKQITNKKAVFVISPQWFVPQGTRKDAFSYYYSPLQTIDWLQDEQNTAMDRYAAQRLLQMPSGSSDRILEGALARVAAGFKPTSAQMTYINYKARVLGSEDEFFSRFGIAGKNLRTVNAQANKLPATYNFNQLNQLAGKIGAAQTDSNSLEISNQFWNTKLKRNYKRLKDSQRHLNYTKSPEFADFQLVLNQFAKTHTDVLFIIPPINQRWSAYTGLSMKMIAQFDKKIQYQLKSQGFNNVLDLTQDGGKDYFMTDTIHLGWRGWLAVDQKVDPFLTKKTKPVHYQINDDFYSKEWQLLKPSEIKDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPY2</accession>
    <name>F9UPY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1-6C</name>
        <name evidence="2" type="ordered locus">lp_2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2023"/>
    <dbReference type="EnsemblBacteria" id="CCC79271">
        <property type="protein sequence ID" value="CCC79271"/>
        <property type="gene ID" value="lp_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2023"/>
    <dbReference type="HOGENOM" id="CLU_041900_1_3_9"/>
    <dbReference type="OMA" id="RYNDYII"/>
    <dbReference type="PhylomeDB" id="F9UPY2"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="30179" checksum="8651B42ACE671B84" modified="2011-10-19" version="1">MSFIAVDVQTHDIITILPGRKNADIKDFFLNHYSKRHRDRVTRVVMDFNSQYQPAIRTLFPHAKLVADNFHLVQMALRSLNQTRVQLMKRFNPQSREYRVLKYYWRLYLKDYDSLEKRKPQWFAHLKDRMTQEQLVVAGLNLDQQFRQTYQAAHALVKAFQKRDYRSFKAALGHVENISPQLMTNIKSFIKNRQLIKNMTTGRLSNGPVEGVNRKIKQIKRTAYGYKNWQNFIYRIQIEFKIKIEKKSPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ75</accession>
    <name>F9UQ75_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ComE operon protein 1, DNA receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">comEA</name>
        <name evidence="4" type="ordered locus">lp_2131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101662.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2131"/>
    <dbReference type="EnsemblBacteria" id="CCC79364">
        <property type="protein sequence ID" value="CCC79364"/>
        <property type="gene ID" value="lp_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2131"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1805"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_1_0_9"/>
    <dbReference type="OMA" id="MVDIKGA"/>
    <dbReference type="PhylomeDB" id="F9UQ75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1825-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="25351" checksum="BEE3793F3024F28B" modified="2011-10-19" version="1">MIDWIKLLKMHWRIVGGVTAVIIILITGWALSQLKQPQPAGTDNLLAHSFNSTSMGGASRTSANADQPATSTQPSNATPSPARPTGASSPGYVDIKGAVNKPGLYQVTASMRVADVIQLAQGMQPQADAQQINLAAKVTDQQVIYVPAKGEQAPAVAPPVVQSTGPTGGTPTSDHAATDKVNLNTADVAALQTLSGIGQKKAEKIIDYRQQHGNFKTIDDLKNVSGFGEKTVVKYKDQLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ80</accession>
    <name>F9UQ80_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2 8">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pycA</name>
        <name evidence="16" type="ordered locus">lp_2136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101664.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2136"/>
    <dbReference type="EnsemblBacteria" id="CCC79369">
        <property type="protein sequence ID" value="CCC79369"/>
        <property type="gene ID" value="lp_2136"/>
    </dbReference>
    <dbReference type="GeneID" id="57025675"/>
    <dbReference type="KEGG" id="lpl:lp_2136"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1810"/>
    <dbReference type="eggNOG" id="COG1038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_2_9"/>
    <dbReference type="PhylomeDB" id="F9UQ80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1830-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
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        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 8 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="14">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="120"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="529"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="738"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
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            <dbReference type="ARBA" id="ARBA00013057"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ82</accession>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, TIGR03766 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC79371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="gene ID" value="lp_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2141"/>
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    <dbReference type="OMA" id="YGRHIAD"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TIGR03766"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="437"/>
            <end position="456"/>
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        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="529" mass="60249" checksum="ACA44EC83B450D8D" modified="2011-10-19" version="1">MMRRYFYQFSQKMITSVWWLLFVPMLLFAVMSPNIILGDNATFGTSTTLLTTGLIIVIVAVLIMNYAYPRVHRGLYRLLITKQLRTAGVLLALVFIGQLVFVTFVHPVSGFDAGMLHYAATSAKHVQEVGVTAYYSLNQNNMPIMLFMHWLSEVTGQTSWQFFDYVTLFFVDLSAAFNLMSVFVVRRSALGIAMYLHAGWLAVFPSIIMPYTDAWGLPLVSFFMLCYFVMSQTKRPPLLRVAAAVGFGVSVTLTYFMKPSSIIPVIAIAIISFLARLRSRQGSQTTMIFVTVAMAILMLESAGLTYHYTNQAIQNQTYIKIDKSRSIPAIHFMAMGVYGSGGYSEKQAIQMAVLPTKAQKTAYSIKMLKRQLKKLGPWGYLEFLVKKQRNNTADGTFGWLKEGNFFRENQKPSNQGFSNWLKNFIYLYGRHIADFRFVAQLWWLVLLVIIALGFGPRWQLIQLLRLAMIGGFIFLLLFEGGRSRYLIQYLPCLLLLGAFSFERAVANIRRVRDWYQRKLRAAIAADESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA6</accession>
    <name>F9UQA6_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">lp_2173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889909.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2173"/>
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    <dbReference type="EnsemblBacteria" id="CCC79395">
        <property type="protein sequence ID" value="CCC79395"/>
        <property type="gene ID" value="lp_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2173"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1856-MON"/>
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    </dbReference>
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            <end position="27"/>
        </location>
    </feature>
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            <end position="482"/>
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        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="326"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="482" mass="50755" checksum="8F1048C1E0FAAD33" modified="2011-10-19" version="1">MRKLIKACGLMVISMLVGLGIVTSALAAKTAPQSPSSPPSSVLGLNLSGGFSQQPIDSNVIGGNSVTLSVRAQRSALEAATSLLSGRKYVWWESTDEGQTYQKIGTNSRTYTFNAPQVTKTTHLYFQVQYDFSGVGAFPDYWSKIAKVTVTPARVVTTGIKVTSDDAWLNNAQTTMVHAALTPEEATDPITWKSSDPSLAAVDEYGNVTAADAATDNSGKADDHGTVTITGTSNGLSDSVKILVGALQDVTVVEGTPATFTLPALPEGVTVSNWYRVKNGKATALNVTDTSYTVKVPTNADDDGTAYYASLSYPVNGKPQTVTTNAALLTVKSGGRLSLSAVPNFNFGTLNLQRLAQGTDLATDPTAVKANDGYDGNNDYRLAVVDDRTVGADWQLMASLSPFTAGNTTIKTARLMLKDSTGVLNQTIPTDGSTTSVYRQTGHQSQTFDVAPSSLQLPATPLATPGEYQSIITWTLAIVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG2</accession>
    <name>F9UQG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional protein: 5'-nucleotidase 2',3'-cyclic phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101693.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2237"/>
    <dbReference type="DNASU" id="1061829"/>
    <dbReference type="EnsemblBacteria" id="CCC79451">
        <property type="protein sequence ID" value="CCC79451"/>
        <property type="gene ID" value="lp_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2237"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1893"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_8_1_9"/>
    <dbReference type="OMA" id="GDIHRIC"/>
    <dbReference type="PhylomeDB" id="F9UQG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1936-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011240">
        <property type="entry name" value="Pesterase_YunD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036361">
        <property type="entry name" value="YunD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="293"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="461" mass="51641" checksum="29F4E8B8776D5320" modified="2011-10-19" version="1">MDEQVTILHTNDIHSHFENWPRIQRYLLTEREQRRQSGSHVITVDLGDAVDRAHPLSEATQGQANVALLNAIGYDAVTIGNNEGLGLTHAALNRLYDRANFDVVLDNLTDTATQRPPQWALPAKIITTARGTRVLLLAFTAPFTLTYPLNGWTPASVKTRFPELLRQYAGQYDVLIVMSHLGINVDRWLAKQFPVIDVVIGSHTHHLLVNGELKNGVLIAAAGKYGEYIGRIELTIDHQHHVKAAAAHTVATASLPIVAGDETLITGWEQQGETLLTRQVVAKVPTQLRPHWHHASDLTALGLAAITDYAKTDLGMLNGGLFMRDLPAGMVNRNDLHTMLPHAMHVIRVTLSGEALWRLVYEMELVRPFLNKFPIKGMGFRGQVFGYIQYQGLTWKTGQHTLLVNGQPVNRQQTYQIALLDHDLFIPFFPTINISGRTEILFEAMLRTVVGDYLMRRWPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT3</accession>
    <name>F9UQT3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79572">
        <property type="protein sequence ID" value="CCC79572"/>
        <property type="gene ID" value="lp_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2391"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2017"/>
    <dbReference type="eggNOG" id="ENOG50349WT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143430_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2057-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12877" checksum="C2A81238AAB1A144" modified="2011-10-19" version="1">MASNSDSIYNVMFYITHHPTEIQFTQPEYTNVVRMGVPDHIKVANPEIYFPDNKLLVNRFQDDFVAKNGNLLDFFFDYTEKKVPNYHEVWVSSAHLPAKHLYFLELSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU7</accession>
    <name>F9UQU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P2a protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2407"/>
    <dbReference type="DNASU" id="1062459"/>
    <dbReference type="EnsemblBacteria" id="CCC79586">
        <property type="protein sequence ID" value="CCC79586"/>
        <property type="gene ID" value="lp_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2407"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2033"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784803_0_0_9"/>
    <dbReference type="OMA" id="CESWTEN"/>
    <dbReference type="PhylomeDB" id="F9UQU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2071-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010572">
        <property type="entry name" value="Prophage_Tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044051">
        <property type="entry name" value="Prophage_tail_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06605">
        <property type="entry name" value="Prophage_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18994">
        <property type="entry name" value="Prophage_tailD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tailD1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Prophage_tail" evidence="1">
        <location>
            <begin position="96"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="393" mass="44471" checksum="5C37DAFC655E66C0" modified="2011-10-19" version="1">MMIQYPKLTISDRLNQHRERLPLADLQETFKESWTVNEKWQVTFAITDSLAYEQAIKLLDVQNIVHYDGQSYVIIQCTKTVSGGVSVYEVTASHLFYRLANNARQNNVKTGTLTYGLSEAVNFMLDNNDQGLTAKFIGDFPRIKIENLGNSSFNKFLQDYTSKFDASYVIDNQQIIFYSATYLKHQPVIDTLFYQHDVENVKLSLDTTSLANEVRCLGKPIDKSSGNNDSQTKYQVDFTYRDDASIQKWGLQRGDPLSDERFTDQGSMTEYARQTVQAQPIATLTTTAWNVTIKQCETVKLVMPNLDWQTTVALNGYERNPFNQFSLPTITFDNASLAVNDINVAMFKHITNAHNHVGKTMVQLMAALGDIQNGDLITDEDTIDKLNELGGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ2</accession>
    <name>F9UQZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 4 AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890145.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2453"/>
    <dbReference type="EnsemblBacteria" id="CCC79631">
        <property type="protein sequence ID" value="CCC79631"/>
        <property type="gene ID" value="lp_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2453"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2070"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026496_0_0_9"/>
    <dbReference type="OMA" id="TVIAGHN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2121-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="582" mass="66514" checksum="2B33A2874C777289" modified="2011-10-19" version="1">MRILIDKIKINKFRKFSELGQIQLGHRITVLSGHNGVGKSSIMSLISSTVGQNKVRLNGSKFQPEFNDYFTIDPEREGHDFPAYEILVDFISQTNTGNYEFAKRVGFKDDRNQDRGIRPLPRPALPLINKNGYQTISQAQDAAFKMIGDIIGKSGSSRVHLPCIYISLSRIMPPGETTLIIEDFDGKTKKLSEELSNKYVEWYNEVLPNSINENSIIAKSVEKKSTGKTRLFILLADATASTQSVGQDNLGGIISALVDFYYLSKTSDDYNGGVLCIDEIEASLHPNAQLKLMLLLDKLSQELKLQILITSHSLTILKEILIQQSKSAVDYQLVYFKGETYPYASKIDSYRSLKADLFNEITVSKPYVKIYCEDEFTVPLLNHLLKAAYDNEILSKSLPEYKIINVALGKDNLRSLIQLDSYFSHVLIVLDGDAKLKDRIKIETYFKNPHVFEGRTERNQPKNVLTLPGFMSPEEFSYVILWEYVNNESQHLQFWRNLERNQDLALMTADKAREAFTPKGDQVKFKDIHDKHDLKLLDFIGKSNILSDYYSLDDNQIKLKDWTNSFKKILVSFEKDLKAMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR00</accession>
    <name>F9UR00_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 17, portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101790.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890153.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2464"/>
    <dbReference type="EnsemblBacteria" id="CCC79639">
        <property type="protein sequence ID" value="CCC79639"/>
        <property type="gene ID" value="lp_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2464"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2077"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033789_8_0_9"/>
    <dbReference type="OMA" id="DEYQMNK"/>
    <dbReference type="PhylomeDB" id="F9UR00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2131-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006427">
        <property type="entry name" value="Portal_HK97"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01537">
        <property type="entry name" value="portal_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="39785" checksum="9FFEB2D6D0ED463B" modified="2011-10-19" version="1">MSFFVKSNTTSGTHDPVADALVSLSSNDPYTFVSAAVLRNSDIYAAINIIASDIASNPIMCDTAIFNTMINQAPNSQMDGYHFKYALAANLLLNGNSFAEILPNHTLKLIANNQLTVEQDDVSGALTYTYTPIGGNSRQIAPNNILHFKYFTKDGVSGISPLYALKDERQIQSAGNKLLTGFFTAGVHGTTIIKVHQSDLGPEAKGNIRKQFDEANTGDNAVNTIVTDDTMDISNLSLNTDVLKLVNSNDWTTRQIAKAFGLPPERLGVENDHSNQEQSGVQYLQGTLQHYFDSFTSELSFKFGHDFTFNTDKLLSLDPQTQQAQAVAGFTGGVMSRNEARAKIGLPPTDDGNIFLNLQKNGVTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB5</accession>
    <name>F9URB5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dxs</name>
        <name evidence="14" type="ordered locus">lp_2610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2610"/>
    <dbReference type="EnsemblBacteria" id="CCC79754">
        <property type="protein sequence ID" value="CCC79754"/>
        <property type="gene ID" value="lp_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2610"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2192"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_9"/>
    <dbReference type="OMA" id="FAPQGMF"/>
    <dbReference type="PhylomeDB" id="F9URB5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2245-MON"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="13">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="583" mass="63778" checksum="3E3320197286471A" modified="2011-10-19" version="1">METPILARIDQPADLKQLSLPELTQLASELRHVLLNKVSQTGGHVGPNLGVVELTIAFHTIFNSPVDKVVWDVSHQSYTHKILTGRKQAWLDPAHYNDVSGYTTPEESPHDYFNIGHTSTSIALATGMAVARDLEGKTGNVMAVIGDGSLSGGLALEGLNIAATLKSNLIILVNDNGMAIAEDHGGIYQNLRELRETNGTSSHNLFKDFGLDYRYVDDGNDLETMLTTFKEIKDVDHPIVLHVHTEKGHGYQPAITNKEAFHWHVPFDLATGQTLHPNTKETYTDVIHATLADELAAKTPITAITAAVPGTYDLKRFARQYPDRYFDVGIAEQESITFAAGQAQQGLRPIVFHSGTFLQRAYDQLSHDLGINKLPVTIMVAGGRINAGDPTHQGIFDVAMLSNIPNLTYLAPTTKEELQAMMHWALHQNNGPVAIRVPSNDVQSVPLAPDFDATKMHTLHAGQQVALLGVGSLLPLATAVQQQLAEQHIDATLIDPRDISDPDTMTLANLKADHQLVVTVEEASLSGGFGEKVSRYYGNSAMRVLNFGAAKRFNDRETTNELRHEFKLTPDQIVTAITDQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL6</accession>
    <name>F9URL6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890369.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2742"/>
    <dbReference type="EnsemblBacteria" id="CCC79855">
        <property type="protein sequence ID" value="CCC79855"/>
        <property type="gene ID" value="lp_2742"/>
    </dbReference>
    <dbReference type="GeneID" id="57026115"/>
    <dbReference type="KEGG" id="lpl:lp_2742"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2295"/>
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    <dbReference type="HOGENOM" id="CLU_017584_10_0_9"/>
    <dbReference type="OMA" id="INHLTVM"/>
    <dbReference type="PhylomeDB" id="F9URL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2346-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="14081" checksum="8D3DB64F56A8EDAF" modified="2011-10-19" version="1">MQFNFNSTEPIYLQVADQIEEAIFTETFAEGEQIPSTTEISKEFHINPATVLKGMNILVDAQLIEKRRGVGMFVIAGAQQRIVEKRRDQFYTDYVKKLVAEAQKLHITQDELAKLIERGFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM0</accession>
    <name>F9URM0_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">lp_2746</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890373.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2746"/>
    <dbReference type="EnsemblBacteria" id="CCC79859">
        <property type="protein sequence ID" value="CCC79859"/>
        <property type="gene ID" value="lp_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2746"/>
    <dbReference type="eggNOG" id="ENOG5030AUT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2617602_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2350-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9331" checksum="63EA82635990744E" modified="2011-10-19" version="1">MGVNSMLSLGIRPGLIASHTIVINDALSYQIRLSKLRLGPDVYRLDIRATTTLGRLTVSHAHYHNFATAQQAFNHQRHQLESH</sequence>
</entry>
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    <accession>F9URU7</accession>
    <name>F9URU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(Glycerol-phosphate) alpha-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagE6</name>
        <name evidence="2" type="ordered locus">lp_2844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.52" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890450.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2844"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79936">
        <property type="protein sequence ID" value="CCC79936"/>
        <property type="gene ID" value="lp_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2844"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2378"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
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    <dbReference type="OMA" id="FFITEEQ"/>
    <dbReference type="PhylomeDB" id="F9URU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2433-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047265">
        <property type="term" value="F:poly(glycerol-phosphate) alpha-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="327"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="514" mass="58337" checksum="1C7B332373DA2360" modified="2011-10-19" version="1">MYYFVNTSINPKKSGIEHAEMKRLALFNQHHVPAKMVTRFFSLSLHQTLTAAGIAAENQINLFDFIQHSSERPTTKMTIEDLHLAPDLRVQSVGRHYEVYQNDQLLMKVNTFLNTQKQLNNVQYYDQNGKLVKTDWYDTRGFKGLEQFYAADGQVASEQVFNPDGEVVYQTFHMADRQNQVQNSLYRFINYEGQDWSFAGETAMTTFFLDELNRRTPHAVFVIDRTYELAYAALHMRTKAFKVMHLHSNHVNDPAHPKTASLNFNYAYALNNLDQWNGVIASTKQQTADFQARFGNQPAVYTIPVGIVDDATLNAPKPSFDQRTAGKIIFVARLAEEKQQDQVIRAFKKVLAQVPNATLDFWGYANGDTGKQLHQLVEQLGLKAAVTFNDYTTDLTAVYNDAQLAMLTSRAEGFALALLEGQAHGVPQIAYDVKYGPRDIIRDGHDGQLVPVNDENALATAMIDLLTQPKKLAMYSQQAYQDAQRFSTTAVWQQWQPLMKAAADFYQVEGATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX4</accession>
    <name>F9URX4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101946.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2874"/>
    <dbReference type="EnsemblBacteria" id="CCC79963">
        <property type="protein sequence ID" value="CCC79963"/>
        <property type="gene ID" value="lp_2874"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2874"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2406"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_1_9"/>
    <dbReference type="OMA" id="PRWGKPE"/>
    <dbReference type="PhylomeDB" id="F9URX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2460-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="30650" checksum="F13C3677F56913F6" modified="2011-10-19" version="1">MNMNNEVIVLFGAGSIGEAIVRRVAAGRNLLLADYNEAKLVEMKQHLTEAGFNVETFQADLSSRESIKTVVAKAQSLGKIMGLVNAAGVSPSQASPEQVLKVDLYGTDVLLEEFGQVMAPGSAGIVISSQSGHRLPALSQADNQALAMTPTEELLDLPILQPDVIKDSLAAYQYAKRTNVLRVAAESVKWQARSARINTISPGIIMTPLAVDELNGPRGAGYKKMFESMVTKRPGTPDEIANLAELLMDRRGAFITGSDFLVDGGITAQYWYGNVSEVRNNGVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY3</accession>
    <name>F9URY3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase, coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890486.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2887"/>
    <dbReference type="DNASU" id="1063272"/>
    <dbReference type="EnsemblBacteria" id="CCC79972">
        <property type="protein sequence ID" value="CCC79972"/>
        <property type="gene ID" value="lp_2887"/>
    </dbReference>
    <dbReference type="GeneID" id="49285440"/>
    <dbReference type="KEGG" id="lpl:lp_2887"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2415"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_0_3_9"/>
    <dbReference type="OMA" id="YYWERDG"/>
    <dbReference type="PhylomeDB" id="F9URY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2469-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="197" mass="21044" checksum="BF0AF8C03218CEE6" modified="2011-10-19" version="1">MEIGIIGAGTVGTVLAKTFARGDHQIKLSRHSGAASLATRRAEFAANVAFVEVAEALQQPLVILAVPFEQAPTVLAQVADYQQRIVVDVTNQFTADFKKIKTAPLTGSEVIARAANNARVIKAFNTIPPEFMDGHVDGPGKRVLFYAGDDVAAKKEFAALVRPLNFRPVNLGKLRHGGSVMQVGGGLGNTHFVQIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY4</accession>
    <name>F9URY4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cblA2</name>
        <name evidence="3" type="ordered locus">lp_2888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890487.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2888"/>
    <dbReference type="EnsemblBacteria" id="CCC79973">
        <property type="protein sequence ID" value="CCC79973"/>
        <property type="gene ID" value="lp_2888"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2888"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2416"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_9"/>
    <dbReference type="OMA" id="NEVCDVN"/>
    <dbReference type="PhylomeDB" id="F9URY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2470-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="390" mass="43159" checksum="3F0200CB1D1EBE50" modified="2011-10-19" version="1">MPFDFETVLNRRHTNAVKWDVADDELPMWVADMDFETAPVIKQALIKRAQFGVFGYEEVPMAYYEAVADWWATEHNFRPQIEWLMFCTGVVPAISSIVRKMTAAGDNVLVQAPVYNIFYHSIENNGRHTLSSDLVARDASYAIDWDDLTKKLADPLTTMMILCNPQNPIGVVWSRATLQRLGELCLKYHVLVVADEIHCDLTLNGNAYTPFSSLTAPVAHNSISCISPSKTFNVAALHAATLIIPDAHVRALVSRGINNDELAEPNSFAIPASIAAYTEGHDWVAALRTKLAANQRQVQTYLTAELPQVKLVEAQATYLLWLDVSQVTTDSAALAAFIRQRTGLFLSAGDVYRGDGNRFLRLNVACPTTTLTDGLARLKAGITAYQQVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9US18</accession>
    <name>F9US18_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="9">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nrdD</name>
        <name evidence="9" type="ordered locus">lp_2932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="740" mass="83731" checksum="9A8E1AED988FA785" modified="2011-10-19" version="1">MLTTTTNDILDQLRPLTVTKRGGAQTKFHPYKIDFVLRRLLATDDEVRVVKQALVAQYQDADNIDTRELRSTMMQILNAQGLTAAAKAYQDYFEAEQQRFAAATNVQGRIEKLFERDASVVHENANKDSTIFNTQRDLEAGAASRAMGLKMLPDVVAKAHLRGDIHWHDLDYSPVTPETNCCLIDFDGMFKNGYKIGNAEVASPRSIQTATAQMAQIIANVASLQYGGCSANRVDQLLAPYAAINYQKHMTDAKKWVPADQREAYAKAKTKKDIYDAMQALEYEINTLYSSQGQTPFTTVNFGLGTSWIEREIQKAILQIRIKGLGKEHRTAIFPKLIFTMKRGLNLSPNDPNYDIKMLAIECSTKRMYPDLLMYDKIKELTGSFKTPMGCRSFLQGWRDENGVEVNSGRMNLGVVTVNLPRIALAAHGDQQLFWEIFEERMATCHEALAYRIERTKEAKPENAPLLYMYGAFGKRLPAGGNVDELFKNQRATISLGYIGIYEVCTTFFGPNWEQDEHALAFAETVVKALRDKCAQWAAESGYHYSLYSTPAESLTDTFCRDDIAKFGRIADITDKEYYTNSFHYDVRKHPTPFDKLTLEERFPQYASGGFIHYCEYPNLTQNPKALEAVWDWAYDHVGYLGTNTSIDQCFKCGFKGEFKATARGFVCPECGNHDPKYCDVVKRTCGYLGNPQQRPMVHGRHVEIASRAKNMSPEMIKNAARYERTKQSDAQRMAGRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9US26</accession>
    <name>F9US26_LACPL</name>
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        <submittedName>
            <fullName evidence="6">Cation transport protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">lp_2943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2943"/>
    <dbReference type="EnsemblBacteria" id="CCC80015">
        <property type="protein sequence ID" value="CCC80015"/>
        <property type="gene ID" value="lp_2943"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
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        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="182"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="459" mass="49336" checksum="37D1FAB259F1C43E" modified="2011-10-19" version="1">MNKKTIGFFSGIAVFAIIYFLPIAGLSAKGQMDLALSLMTVVWWATQIAQPAFVGGIYLMLLIIMNVATPSQVFSSAWTGSIMWLVIGAYLIAGAVNESGLGQRIAYAFIIKFVRSWKGIVISIFALTFILALLIPHPWPRAFMIMSVITVVAETAKMPKRDLAKLGLAVFAASCPLSGVFYTGDTSLNPLAVQASGQSVNFVSYFIYMGVPMIIAAILTMFLFLFLFKPSQEVHIDVEALKQQQAQLGGMTGKEVRTIIWLIIAIALWLTSGITGLDVGWLTLIVALMMSLPVVGGILTAKSWEGVPVNVLVFLTSAIAIGNVGGVTGMNNWIAKTLIPSNLPTNIYLLAIVITVFAMIIHMFMGSVIAVMGITIPAFVAATAHMGISPLAVSLLVFSVTNLHYILPFHNLAVLVGSDPDTGGGYTQKDVMRLGIPLTAVVFVVALVEMFWFHLVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9US79</accession>
    <name>F9US79_LACPL</name>
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        <submittedName>
            <fullName evidence="7">Arsenate reductase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arsC</name>
        <name evidence="7" type="ordered locus">lp_0059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.1" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641672.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888140.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0059"/>
    <dbReference type="EnsemblBacteria" id="CCC77626">
        <property type="protein sequence ID" value="CCC77626"/>
        <property type="gene ID" value="lp_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0059"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.48"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_2_9"/>
    <dbReference type="OMA" id="DNAKERC"/>
    <dbReference type="PhylomeDB" id="F9US79"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-48-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030612">
        <property type="term" value="F:arsenate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014064">
        <property type="entry name" value="Arsenate_reductase_ArsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02691">
        <property type="entry name" value="arsC_pI258_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="141" mass="15336" checksum="716A1FA43BF0D994" modified="2011-10-19" version="1">MPKIYFLCTGNACRSQMAEGFAQQLLGPNWQVASAGVETHGLNPLAVQVMSEVGIDISDQVSKLIDLTYLNQCAVVVTLCGDARDRCPVTPATVTRLHWPLPDPARTTGSVSDQLLVFRQVRDQIKARVIDLARTLNVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9US98</accession>
    <name>F9US98_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642229.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890542.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80028">
        <property type="protein sequence ID" value="CCC80028"/>
        <property type="gene ID" value="lp_2964"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2964"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2473"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2302322_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9US98"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2524-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="11084" checksum="CD7F6F20DEB9E77B" modified="2011-10-19" version="1">MVMRDLNIGTKVGLGVLNDRWAALVLINLKAAPTEIMNLRQRVRGLSTLKLLNVLAKLTELGLVATAGNYQFQLTTAGISFQKQLHQLEVWGDQMIVAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA1</accession>
    <name>F9USA1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2967"/>
    <dbReference type="EnsemblBacteria" id="CCC80031">
        <property type="protein sequence ID" value="CCC80031"/>
        <property type="gene ID" value="lp_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2967"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2476"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_14_2_9"/>
    <dbReference type="OMA" id="MADHRAQ"/>
    <dbReference type="PhylomeDB" id="F9USA1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2527-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="178" mass="19893" checksum="78EC5BD5A9FC05E1" modified="2011-10-19" version="1">MTVNNRDLFSSFGKLFQNRAFVMAVAQQFHFGDHGNDRSGRGQMGILRVLADAPAGLTNAEIAEILDIRPSSVSATLNRLEDGGLIEREPSAHDKRVVIVRLSDRGREMADHRAQGTSDLADQLFGNLTDDERNQLQHLLDKLRANADDIDIQDLMQFGQQHGFGPRPGWGHGHHWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9USC8</accession>
    <name>F9USC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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            <end position="26"/>
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            <end position="52"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="20925" checksum="EAF1A811C20276EB" modified="2011-10-19" version="1">MMHYGVLALTFLSVNLDFFLMLVFLLKKYRLWQVLLGYLLGNLILLTASFFVGKALTLFLPEWLLGFLGVLPIWLAFHDDDDDTADRAGGSPVINVLVTYLAVCAGCNLSIFLPVLVGESMVHFVMTLGFIGILTMLVVLIINQVAEIKAVQKQIAAHGERLMKICYVVIGLYVFWDSGLISHLIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC80128">
        <property type="protein sequence ID" value="CCC80128"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="69"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="42669" checksum="319E54D354118CD2" modified="2011-10-19" version="1">MTKQFNPSWTLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVSLVLLLGLIWLARPAKSTDRHCVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_0081</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77645.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0081"/>
    <dbReference type="EnsemblBacteria" id="CCC77645">
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        <property type="gene ID" value="lp_0081"/>
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    <dbReference type="KEGG" id="lpl:lp_0081"/>
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    <dbReference type="OMA" id="ALHPYNV"/>
    <dbReference type="PhylomeDB" id="F9USR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-67-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="224" mass="24803" checksum="7EDF745AD94AD733" modified="2011-10-19" version="1">MKKVLIVETNITRYQGTNEPTGLWLGEAAEFVDEMQQAQIAVDYVSPNGGFVPLDPRSMKYTDAATMAVYEDSDFINRALKNTLKPSQVDPDDYTAIYYTGGHGVMWDFPDNPELQAIALAIYQHGGYVTSVCHGIAGLLNIKDQTGQYLIAGKTITGFTATEELIAGKKRIVPFLNRERATARGAIFSQHRFYREYAITDGQLITGQNPFSARAVARQLIAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS6</accession>
    <name>LARQ_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nickel permease LarQ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Energy-coupling factor transporter transmembrane protein LarQ</fullName>
            <shortName evidence="4">ECF transporter T component LarQ</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">larQ</name>
        <name evidence="6" type="ordered locus">lp_0101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable transmembrane component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May form an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, LarO), a transmembrane protein (T component, LarQ) and a fused possible substrate-capture protein (S component, LarMN) of unknown stoichiometry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced by L-lactate but not by a racemic mixture of DL-lactate. Makes part of the larR(MN)QO operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Deletion of both larO and larQ leads to a loss of lactate racemase activity. Addition of Ni(2+) (but not Co(2+)) restores lactate racemase activity in this mutant.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CbiQ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100882.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9USS6"/>
    <dbReference type="SMR" id="F9USS6"/>
    <dbReference type="STRING" id="220668.lp_0101"/>
    <dbReference type="EnsemblBacteria" id="CCC77657">
        <property type="protein sequence ID" value="CCC77657"/>
        <property type="gene ID" value="lp_0101"/>
    </dbReference>
    <dbReference type="GeneID" id="57026943"/>
    <dbReference type="KEGG" id="lpl:lp_0101"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.81"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_3_0_9"/>
    <dbReference type="OMA" id="MECRGFT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-79-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441650" description="Nickel permease LarQ">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="31307" checksum="8C9C4D998A9AD479" modified="2011-10-19" version="1">MKPTRPNTDIPAWLQTTTTTPTPAIKAKFWQRNQRHLRQLLSRLAQPAPVTATSHWRVAPQFKLIQLLLLVILIALSNNLILLWSLALLVGCQLLWLPPRQLRRFMGSWLISVGMAMLFVLPSYWLAGPTTLLFFGLKTSLMLANAQYYRLTTPFQDLLAGLKALHCPDLLIMTLAIAITYLRMLGQHLLLTMEALELRTVAPTAHPYRLIGALFGNLYLKSYTYALELYAAMEARGFNGHYVRSTGRRTHWRDYLALSPAIIVWILFIFWRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST1</accession>
    <accession>F9UST2</accession>
    <name>LARC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein</fullName>
            <shortName evidence="7">P2TMN nickel insertion protein</shortName>
            <ecNumber evidence="3 4">4.99.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase accessory protein LarC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase activation protein LarC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lactate racemase maturation protein LarC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lactate racemization operon protein LarC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nickel-pincer cofactor biosynthesis protein LarC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">larC</name>
        <name evidence="8 9" type="synonym">larC1/larC2</name>
        <name evidence="8 9" type="ordered locus">lp_0106/lp_0107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6750" last="6761">
            <title>Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Goffin P."/>
                <person name="Deghorain M."/>
                <person name="Mainardi J.L."/>
                <person name="Tytgat I."/>
                <person name="Champomier-Verges M.C."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="16166538"/>
            <dbReference type="DOI" id="10.1128/JB.187.19.6750-6761.2005"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>RIBOSOMAL FRAMESHIFT</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>NICKEL-BINDING</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="5598" last="5603">
            <title>Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
                <person name="Hausinger R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27114550"/>
            <dbReference type="DOI" id="10.1073/pnas.1600486113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54784"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:137372"/>
            <dbReference type="ChEBI" id="CHEBI:137373"/>
            <dbReference type="EC" id="4.99.1.12"/>
        </reaction>
    </comment>
    <comment type="alternative products">
        <event type="ribosomal frameshifting"/>
        <isoform>
            <id>F9UST1-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>F9UST1-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_059080"/>
        </isoform>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Induced by L-lactate and repressed by D-lactate. Is thus regulated by the L-lactate/D-lactate ratio. Makes part of the lar operon (larABCDE).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Deletion of this gene leads to a loss of lactate racemase activity.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform 1</molecule>
        <text evidence="3">Expression of the full-length LarC protein requires a -1 ribosomal frameshift to allow contiguous translation of larC1 and larC2 ORFs, leading to the functional form of the protein. The exact position of the frameshift cannot be determined but likely occurs in the stretch of 10 consecutive adenines present at the end of larC1.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform 2</molecule>
        <text evidence="3">Produced from conventional translation of the larC1 ORF. Expression of LarC1 alone does not show lactate racemase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LarC family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CCC77662" version="1"/>
        </conflict>
        <text>The exact position of the ribosomal frameshift cannot be determined but likely occurs in the 10 consecutive adenines present at the end of larC1.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CCC77663" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.99.1.12" evidence="3 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77662.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77663.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888177.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="6BWO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.03 A"/>
        <property type="chains" value="A/B=272-420"/>
    </dbReference>
    <dbReference type="PDB" id="6BWQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B=272-420"/>
    </dbReference>
    <dbReference type="PDB" id="6BWR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.81 A"/>
        <property type="chains" value="A/B=272-420"/>
    </dbReference>
    <dbReference type="PDBsum" id="6BWO"/>
    <dbReference type="PDBsum" id="6BWQ"/>
    <dbReference type="PDBsum" id="6BWR"/>
    <dbReference type="AlphaFoldDB" id="F9UST1"/>
    <dbReference type="SMR" id="F9UST1"/>
    <dbReference type="STRING" id="220668.lp_0106"/>
    <dbReference type="EnsemblBacteria" id="CCC77662">
        <property type="protein sequence ID" value="CCC77662"/>
        <property type="gene ID" value="lp_0106"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77663">
        <property type="protein sequence ID" value="CCC77663"/>
        <property type="gene ID" value="lp_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0106"/>
    <dbReference type="KEGG" id="lpl:lp_0107"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_1_0_9"/>
    <dbReference type="OMA" id="DMFIGAL"/>
    <dbReference type="PhylomeDB" id="F9UST1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-84-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-20307"/>
    <dbReference type="BRENDA" id="4.99.1.12">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="chain" id="PRO_0000441654" description="Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_059080" description="In isoform 2." evidence="6">
        <original>KLSQQIVNRTADAVLMIEANLDDQTGEGLGYVMNQLLTAGAYDVFFTPIQMKKDRPATKLTVLGNVNDKDLLTKLILQETTTIGVRYQTWQRTIMQRHFLTVATPYGDVQVKVATYQDIEKKMPEYADCAQLAQQFHIPFRTVYQAALVAVDQLDEEA</original>
        <variation>N</variation>
        <location>
            <begin position="263"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="turn" evidence="12">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="358"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="381"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16166538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="27114550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6BWR"/>
        </source>
    </evidence>
    <sequence length="420" mass="46391" checksum="ABDD9A1F1486C404" modified="2017-09-27" version="2">MQTLYLDAFSGISGDMFLGALLDLGLDFEQLKTELAKLHVHGYELTQQREAQSSIYGTSFDVQVAGGKDHGFVEHHHHQHEAGHHHDHEARHLADIEALIDGSDLSDTVKHHAKAIFMEIAQAEAAVHHMPLAEVHFHEVGALDSIVDIVGCCIGLELMQIDTIMASPLSDGSGFINVAHGQMPVPVPAVMQMRVGSAIPIQQRLDVHTELITPTGMGLVKTLVREFGPLPENAVPTRVGYGFGKRDTGGFNALRAVLFEKKKLSQQIVNRTADAVLMIEANLDDQTGEGLGYVMNQLLTAGAYDVFFTPIQMKKDRPATKLTVLGNVNDKDLLTKLILQETTTIGVRYQTWQRTIMQRHFLTVATPYGDVQVKVATYQDIEKKMPEYADCAQLAQQFHIPFRTVYQAALVAVDQLDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU4</accession>
    <name>F9USU4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0121"/>
    <dbReference type="EnsemblBacteria" id="CCC77675">
        <property type="protein sequence ID" value="CCC77675"/>
        <property type="gene ID" value="lp_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0121"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.99"/>
    <dbReference type="eggNOG" id="ENOG50309WV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287495_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-97-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="26914" checksum="027C71FBC3556AB3" modified="2011-10-19" version="1">MVKQGHYAKVSKQKRLRQLKQRRQAQEKRAVMPEMVSEFLQVRYHLTQAAKQRPVMRQMMQRFMAQWLAAGQAELSDNGQTTWSVVALTKQTLQTFNRQLPWQGYALVDQEMARWTAFLNKEVPAVPLSERITLTEALSPVTWQACLSEQLAINALLALTGDSRQLGQITTEQVRQLQTSIQTATGIDWEKVAQLLDSTVIAQNTLSEAGLDDKTHQWLEKLKKLTPQDFNDHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD3</accession>
    <name>F9UTD3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ceramidase_alk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3232"/>
    <dbReference type="EnsemblBacteria" id="CCC80251">
        <property type="protein sequence ID" value="CCC80251"/>
        <property type="gene ID" value="lp_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3232"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2699"/>
    <dbReference type="eggNOG" id="COG3356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030011_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2739-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ceramidase_alk" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="413" mass="46240" checksum="C95422FB5E5D3AF5" modified="2011-10-19" version="1">MLVGHARKDITPTEPFYLLGYKTELRNQPAKGIHDHIYINALLFYDDKGNECFLATGDLLELEDIVAADIRQKISRKYGIAMDHVIIGVTHDHHSVRDYHRTWEFGKFSQTYYDFFVDSFVQAFEDCRETLTDVTVQYGQQEIFGFYSNRNHANKPSDNAVSVIKFIADGHAVAGIVNMAVHSTVLGPDNQYLTADLAGNTCTKLAKEWGFFPLMLIGCAADSSNRYERQGRDFAELERASSGLAVAISKIQTPKRLCLGKIQTLTLSHEVVNDKPIYDRKLRTMINDLRSGVIKAIGSQSVEAIVEKCEDQLNKPQFHDLLSLQLLDIGELRLFVFPGELASAGAKSLRASTDKTVLVAGYCNGFHYYFLQAQDYGLSFETIGNPVPAGTFEEIIAKFVTGSQILDVYEVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTE8</accession>
    <name>F9UTE8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_3250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643468.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890780.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3250"/>
    <dbReference type="EnsemblBacteria" id="CCC80266">
        <property type="protein sequence ID" value="CCC80266"/>
        <property type="gene ID" value="lp_3250"/>
    </dbReference>
    <dbReference type="GeneID" id="57026530"/>
    <dbReference type="GeneID" id="66450781"/>
    <dbReference type="KEGG" id="lpl:lp_3250"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2714"/>
    <dbReference type="eggNOG" id="ENOG502ZSXP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2666532_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2754-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8730" checksum="2B7A8BC38BE3BF4D" modified="2011-10-19" version="1">MGLFRHHNQMPPRIKRKLKQRLLPVAAMEITATTIVVADVLTAKSFRRGHRLGWLLLAFVQPFGPWLYFAFGQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH3</accession>
    <name>F9UTH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">qacC</name>
        <name evidence="6" type="ordered locus">lp_3284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890805.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3284"/>
    <dbReference type="DNASU" id="1061844"/>
    <dbReference type="EnsemblBacteria" id="CCC80291">
        <property type="protein sequence ID" value="CCC80291"/>
        <property type="gene ID" value="lp_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3284"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2741"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_0_2_9"/>
    <dbReference type="OMA" id="IAYSLWC"/>
    <dbReference type="PhylomeDB" id="F9UTH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2779-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="13635" checksum="B751B55CEDB6D558" modified="2011-10-19" version="1">MMRAWIQLVIAIGVEIVGTSLLKLSSGFKYPLIGIVGMLLYGLAIFSFSRALSKIPLSVGYAIWAGVGTAATGLIGIWAFGEILTGLKTLGFMAIITGVILLNMPAKTTKSTTATPRSARWRTRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI2</accession>
    <name>F9UTI2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydropteroate synthase</fullName>
            <ecNumber evidence="4">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folP</name>
        <name evidence="9" type="ordered locus">lp_3294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642512.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890814.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC80300">
        <property type="protein sequence ID" value="CCC80300"/>
        <property type="gene ID" value="lp_3294"/>
    </dbReference>
    <dbReference type="GeneID" id="57026562"/>
    <dbReference type="KEGG" id="lpl:lp_3294"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2750"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_1_2_9"/>
    <dbReference type="PhylomeDB" id="F9UTI2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2788-MON"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="8">
        <location>
            <begin position="118"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="382" mass="43378" checksum="A8624B9596B376A5" modified="2011-10-19" version="1">MLVQDITSSLAQATDFASQALNAQVQRQQQLVLRFSDYNREQQLRLTQLCQQLDGVVQASPEQLTVLLNQTAGRQLTHQWSRVFTDQATTQIQLTQIMKQYDVFWQAGEHRFNLTKKPMIYGIMNITPDSFFDGGQYKTKDDVLNHVDAMLQAGADVIEVNGQTTRPGFTEVTPQVELDRTLPYIRAIKARFPEAVLAVDTYKYDVMQAVLEEGVSIINDVNAFTDDPRKLKLMADSRVGLLTMHSSRDQEYTDLTSSMRGFFEQNLAALTSHGIDIERIALDQGIGYSQVAHGEQDYVMMRNIDEFNYLRRPMMVAISRKGYLGLLLGLKKEDRLPMTLVTEAAMMLKGGRIIRVHDVAETKQLITLLGRIENGYWLSNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTU7</accession>
    <name>F9UTU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug-efflux transporter, major facilitator superfamily (MFS), EmrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_0348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100971.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888381.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0348"/>
    <dbReference type="EnsemblBacteria" id="CCC77867">
        <property type="protein sequence ID" value="CCC77867"/>
        <property type="gene ID" value="lp_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="57027158"/>
    <dbReference type="KEGG" id="lpl:lp_0348"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.295"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_9"/>
    <dbReference type="OMA" id="LDIIWRM"/>
    <dbReference type="PhylomeDB" id="F9UTU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-289-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="481" mass="51449" checksum="7F1CEC7FF6E62C98" modified="2011-10-19" version="1">MKTMSFATDPQIQKHRWWILVAVCLFTFMSTLDGSIVNIALPVMSKDLAIPMNQAEWVVSIYLIVICALLLLFGKLGDIYGKIRVFKIGSLLFIIGSLLSGFSVGLPFLLIARSIQAVGAAMTMSTNNGIITEVFPFKERGRALGMIGSFVALGSIAGPGIGGLILAHLSWGYIFWINVPVGILAMILGAMILPKDVTTTQQPLDKTGAGLFAVLMVALFAGVFIGQQIGFLQPVILALFAVAIVTLIIFVRVELRHENPLLALQLFKNARFSISILCALLIFIANFFFNVIAPFYLENARGLAANYAGYALMVFPIVQVVVAPIAGTISDKIGPELLTFVGLVLISISQVGYMVVGLATPLWFFLLFVGLVGFGNGIFMAPNNSIVMSSVAVKDLGVAGGINALARELGMIVGISVATTVLYSAMSQSAGYKVTSYLPAHPEIFIDGMHIAFVVSLGICLVATVITGGRLLKHRRTAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU09</accession>
    <name>F9UU09_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bacteriocin ABC-transporter, ATP-binding and permease protein PlnG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">plnG</name>
        <name evidence="12" type="ordered locus">lp_0423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888443.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UU09"/>
    <dbReference type="STRING" id="220668.lp_0423"/>
    <dbReference type="MEROPS" id="C39.001"/>
    <dbReference type="EnsemblBacteria" id="CCC77929">
        <property type="protein sequence ID" value="CCC77929"/>
        <property type="gene ID" value="lp_0423"/>
    </dbReference>
    <dbReference type="GeneID" id="57024225"/>
    <dbReference type="GeneID" id="66448499"/>
    <dbReference type="KEGG" id="lpl:lp_0423"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.344"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="OMA" id="QQSHFIE"/>
    <dbReference type="PhylomeDB" id="F9UU09"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-351-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043214">
        <property type="term" value="F:ABC-type bacteriocin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005897">
        <property type="entry name" value="Pept_C39_ABC_bacteriocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01193">
        <property type="entry name" value="bacteriocin_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="11">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="169"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="482"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="515"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="716" mass="79953" checksum="3707A9AAD9407D0E" modified="2011-11-16" version="1">MHWRNYVAQVDEMDCGVAALAMILKNYGSTTSLAYLRNIAKTSLEGTTALGLVKTAEKLGFETKAIQADMSLFEVQDLPLPFIVHVTKNGDLQHFYVVVKTSKTHVVIADPDPTVAVISMSKERFESEWSGVALFFAPKSEYKPVKQDKGSLWGFIPSLLKQRRLVINIVLAAVLITIISICGSYFLQAVIDTYIPNNMHSTLAVVAIGLIVFYTFQAIFTYAQNFLLAVLGQRLSIEIILGYIRHVFELPMSFFATRRTGEIVSRFTDASKIIDALASTIVSLFLDVSIVIIMGAILVIQNMTLFWITLLSLPIYAVVILAFNKSFERLNQKEMESNAILSSAIIEDLHGIETVKALNGETERYQKIDSEFVDYLRKSLAYLKADTLQQALKLFIQLVLEVVVLWVGANLVIHNQLSVGELMTYNALLAYFVNPLQNIINLQTKLQSAKVANNRLNEVYLVASEFEASRPIHNESQLNGDIKLQGVSYRYGYGENVLDDVNLTIRQHDKVAIVGMSGSGKSTLVKLLIDFYQPNSGDVILNGFNVKNIDKHTLRTHINYIPQEPYIFSATIEENLRLGNRSGITEKDIAKACQLALIDTDINKMAMQYQTKLDENGNTLSGGQRQRLTIARALLSPAQVLIFDESTSGLDAITEKQLIDNLVAMTDKTIIFIAHRLSIAKRTNHIIVLHDGRVAEEGTHAALLNEHGYYYDLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU32</accession>
    <name>F9UU32_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
            <ecNumber evidence="3">1.1.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvaA</name>
        <name evidence="4" type="ordered locus">lp_0447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:14833"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; (R)-mevalonate degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.88" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101011.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888466.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0447"/>
    <dbReference type="EnsemblBacteria" id="CCC77952">
        <property type="protein sequence ID" value="CCC77952"/>
        <property type="gene ID" value="lp_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0447"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.367"/>
    <dbReference type="eggNOG" id="COG1257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_9"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="PhylomeDB" id="F9UU32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-373-MON"/>
    <dbReference type="UniPathway" id="UPA00257">
        <property type="reaction ID" value="UER00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140643">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="424" mass="45482" checksum="53DDA1F632028EBB" modified="2011-10-19" version="1">MTADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLAVNLVVDGVDHIVPMVTEEPSVIAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPAATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLGQGYLSIDLFVDVQAAMGANMLNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIASASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTSDGRMLHGELELPLPVGIVGGSIKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALRALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELASQQDLATTQQLIAELRQTKEETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU71</accession>
    <name>F9UU71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 3, phage-like repressor,N-term domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890887.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3388"/>
    <dbReference type="EnsemblBacteria" id="CCC80373">
        <property type="protein sequence ID" value="CCC80373"/>
        <property type="gene ID" value="lp_3388"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3388"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2824"/>
    <dbReference type="HOGENOM" id="CLU_2734976_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2861-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="71" mass="8129" checksum="031E777FE9B98C7B" modified="2011-10-19" version="1">MNDLVTLTSQRLDAEAYTTAEIISQYAEIGLRTVNNRINQYKDDLMEFGMLRFSTINVQNYPADAHKSITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU77</accession>
    <name>F9UU77_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642982.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890893.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80379">
        <property type="protein sequence ID" value="CCC80379"/>
        <property type="gene ID" value="lp_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3394"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2828"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085303_2_0_9"/>
    <dbReference type="OMA" id="YVKHAHI"/>
    <dbReference type="PhylomeDB" id="F9UU77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2866-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17592" checksum="509FF53E19CF6211" modified="2011-10-19" version="1">MMEEFGSTSNYLLSWEELPAVPVYMEQLLQLVNETIQPLGLPAVTKTMINSYVKQHFFSRPVGHRYTRNQIVAVLVVSILKTDFSLPVISKAILQIRDSRQIEPRYQQFRQAFESTLAGQPVVLSTVDPLARAIQLAAQTVAAHLLTIRALNELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU79</accession>
    <name>F9UU79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transporting P-type ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pacL3</name>
        <name evidence="9" type="ordered locus">lp_3398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102147.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890895.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3398"/>
    <dbReference type="EnsemblBacteria" id="CCC80381">
        <property type="protein sequence ID" value="CCC80381"/>
        <property type="gene ID" value="lp_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3398"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2831"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_9"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="PhylomeDB" id="F9UU79"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2868-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="870" mass="93354" checksum="398E357306F8D10D" modified="2011-10-19" version="1">MQNYQNAPFKPTPESGLTTTAVTTQLTKFGKNELVAARPVPLWRKIWQHMSDVSSLVLLFAVGLATYLALAQNGGWTKTIVIGAILVINVCIGLYQEASAEKSLAALKSMSLPTANVRRDGKVQTIAAPEIVPGDLVLLKAGDQVPADAVVLEATNLAVDEAVLTGESEAVEKSIYQDTGELDDNCQVYAGTAVTAGTALIQVLTTGMATELGQIAGLLNKTKQRATPLQGRLNRLSSWLTTFAVLGGITIFALSVWVQNQGLADSLMIGVSLAVAAVPETLPIIVTISLSHGVRRMADRNAIMRRVSAVETIGSVDVIASDKTGTLTQNRMTITKYWTPTTGIMTTEQPLPSAGQTLMRYLGLATNAEINHVDGEEQAIGDATELAVIRWLAQHDLDRPSLEAQTPRIAEDPFDSTKKMMTTVHELAHGRRLVIVKGAWDRLPLKPDQASLAAGQVAHDEFGQAALRVLAVGYRIIPADVQTTDWDDLTADLQLAGLIGLIDPPRPEVIPAIRAAKQAGIFPVMITGDHLVTAKAIAEEIGILTPGLQAISGDELRQLSDEELTAQIDQIAVYARVSPSDKIRIVQAWQSLGKTVAMTGDGVNDAPALKAADVGIAMGITGTEVSKEAADMVLTDDNFATIMAAVKEGRTVYQNIIKAVEFLVGVNFAQIFLMVGAVLFGWGAPLLAEQLLIINVLADGIPGFFISQEPGEPQAMQQPPVSNDESILARGLGQRLFIRAATFTVLTLGIYAFGRFGLTNGQAPVGMTMVFLVLALGSMIDIYAIKDRRPLSWSSMMRNPMLNRGLLLGILVVLAIAVIPPFRSFFSLVTLPALGWLTVLVATLIPTFVLELNKRWQARRQSRLVVNTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU82</accession>
    <name>F9UU82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5 diketo-D-gluconic acid-like reductase, NADP dependent (Promiscuous)</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102149.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890898.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3403"/>
    <dbReference type="EnsemblBacteria" id="CCC80384">
        <property type="protein sequence ID" value="CCC80384"/>
        <property type="gene ID" value="lp_3403"/>
    </dbReference>
    <dbReference type="GeneID" id="66450894"/>
    <dbReference type="KEGG" id="lpl:lp_3403"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2834"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="PhylomeDB" id="F9UU82"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2871-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="286" mass="31687" checksum="2AE382846B7913D2" modified="2011-10-19" version="1">MTALTKLTDTYTLNNGTKIPIVGFGTWQTPDGQVAYDSVLAALKAGYRHIDTAAAYGNEESVGKAIADSGVAREDLFVTTKLWNADHGYDAAKKALDTSLAKLGLDYVDLYLIHWPNPAAMRDNWEQLNADTWRAMEEAYTARKARAIGVSNFRPKHLDALLKTAKVVPAVNQIFLNPSDMEDEVVAYNRKHDILSEAYSPLGTGKIFSIPELKTLADKYDKSVAQVVLRWSLQHGFLPLPKSVHADRIEQNTELFDFELSDDDMKVIDGFHGVAGLANDPDQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB4</accession>
    <name>F9UUB4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA3</name>
        <name evidence="4" type="ordered locus">lp_3437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643543.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890930.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3437"/>
    <dbReference type="EnsemblBacteria" id="CCC80416">
        <property type="protein sequence ID" value="CCC80416"/>
        <property type="gene ID" value="lp_3437"/>
    </dbReference>
    <dbReference type="GeneID" id="57026662"/>
    <dbReference type="KEGG" id="lpl:lp_3437"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2864"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_9"/>
    <dbReference type="OMA" id="MFAPTYG"/>
    <dbReference type="PhylomeDB" id="F9UUB4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2904-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11904" checksum="4E708967FAD7C7C6" modified="2011-10-19" version="1">MIKEIHDQDFAKETDTGIAVIDFRADWCPPCRMMDPILKSLSEDPAYKDQVNFVSLNIDHDQATASQFQVQGIPTFLIKKDGQVVSHMVGARPKPDFEAELKKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF8</accession>
    <name>Q6LWF8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">orf19</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133733.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723569"/>
    <dbReference type="EnsemblBacteria" id="CAG17850">
        <property type="protein sequence ID" value="CAG17850"/>
        <property type="gene ID" value="CAG17850"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17850"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3097"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035706_0_2_9"/>
    <dbReference type="OMA" id="MHTIARS"/>
    <dbReference type="PhylomeDB" id="Q6LWF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3150-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="180"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG17850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="39126" checksum="37719ADDC19F916E" modified="2004-07-05" version="1">MMQEQNTTVRKKGQHLTSFERGRIATLHSQGYSNRAIARALNVCHQTINNELCRGEIDQVKKVNGQRQYYAVYSPETAQAKYEANRAHCHRPLKLVGVADFIDYFTTHLRQDGWSPDATVGRAKLEGLYQPEEMVSTKTLYHYIDAQLLEVRNLDLLEKTRHRAKHHHSIKHKRLAGRSIDERPKSIDQRQEFGHFELDTVVGKRNGQESVILTLIERQSRCQILRLIDGRDADSVNYELAKICQEYGSIMKSVTADNGAEFSEVGAVLTGVADLYYAHPYRSSERGTNEAHNRMIRRDVPKGLSMDILGPHDIQAVESKLNNLPRRQTGYQTPKELFSAASAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S59</accession>
    <accession>F9ULD8</accession>
    <name>AGRB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative AgrB-like protein</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_3582</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AgrB family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102234.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891059.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S59"/>
    <dbReference type="SMR" id="Q88S59"/>
    <dbReference type="STRING" id="220668.lp_3582"/>
    <dbReference type="EnsemblBacteria" id="CCC80545">
        <property type="protein sequence ID" value="CCC80545"/>
        <property type="gene ID" value="lp_3582"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3582"/>
    <dbReference type="eggNOG" id="COG4512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098969_2_2_9"/>
    <dbReference type="OMA" id="MKFAIVY"/>
    <dbReference type="PhylomeDB" id="Q88S59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3032-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00784">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00793">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0673">Quorum sensing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000168139" description="Putative AgrB-like protein">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00784"/>
        </source>
    </evidence>
    <sequence length="200" mass="22323" checksum="A7575BBB7C9212F1" modified="2003-06-01" version="1">MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNVIPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLESDLLCTILTAVTFVGVPYLIQFTDGIPELFRFILCLLLTVPIGMFSPAVTRKNPIKSQSLKRALKHKAIITSLVFSFLQFLVSNNLGTIIVVSLLLVFTLIVPLKGGKSDEAENV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88T09</accession>
    <accession>F9UTB0</accession>
    <name>RSMG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">lp_3201</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102076.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890742.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88T09"/>
    <dbReference type="SMR" id="Q88T09"/>
    <dbReference type="STRING" id="220668.lp_3201"/>
    <dbReference type="EnsemblBacteria" id="CCC80228">
        <property type="protein sequence ID" value="CCC80228"/>
        <property type="gene ID" value="lp_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3201"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2676"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_2_9"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="PhylomeDB" id="Q88T09"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2716-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184268" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="244" mass="26757" checksum="D80A47923E928AA2" modified="2003-06-01" version="1">MNPEEFKQALAQHEIALTAKQLAQFALYFQLLVTTNKQFNLTTITAEPEVYLKHFYDSLTPAFYVPALRDQPLTICDVGAGAGFPSIPLKIAFPQLQVTIVDSLNKRINFLNDLVQQLGLTGVKTFHDRAETFAGKKSAHRESYDIATARAVARLSVLSELCLPLVKIGGQMIALKAANASTETAEGTYAVQQLGGQIVQDEAFSLPVTADPRHIIVIDKKKPSPKRYPRKPGTPAKQPLTAPM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88T65</accession>
    <accession>F9USN2</accession>
    <name>LEPA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4 2</fullName>
            <shortName evidence="1">EF-4 2</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA2</name>
        <name type="ordered locus">lp_3120</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890676.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88T65"/>
    <dbReference type="SMR" id="Q88T65"/>
    <dbReference type="STRING" id="220668.lp_3120"/>
    <dbReference type="EnsemblBacteria" id="CCC80162">
        <property type="protein sequence ID" value="CCC80162"/>
        <property type="gene ID" value="lp_3120"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3120"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2609"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_9"/>
    <dbReference type="OMA" id="HREDAPN"/>
    <dbReference type="PhylomeDB" id="Q88T65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2655-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176287" description="Elongation factor 4 2">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="595" mass="65272" checksum="2802961162F8C85C" modified="2003-06-01" version="1">MKQSHIRNFAIIAHIDHGKSTLADQIMSLTQTVSAREQHAQLLDDMTVEQAHGVTVKARTVRNYYQADDGQEYEYNLIDTPGHVDFNYEVAKSLAATEGAILLVDATQGVQAQTIANYRIAKQRQLTLIPVLNKVDLPSADIDAALAQLNDLDSAFTPEQVLQISAKTGQGVPAVLEAIKQRLPAPQGDLHQPLKALVFDSLYDPYQGVIAYVRLIDGQLKSQQALCLMQGQQDFNGKAIGVFAPQMHPQESLSAGDVGYVVTGIKDPRKVRVGDTLTSVATPTQRPLAGYQPAKSMVFAGLYPKNNDYPALKEAVQKLNLNDPSFTYVEERSEALGVGFRCGFLGTFHLQIIRERLHDEYGVDVLTTAPNVTYHVTLTNGQQVIVNNPVQFPAFSLIKEVTEPFMKAEITMPADNLNAVLKLAEQHKGTLIDLANSGDLIVASLKIPLSEIAYHFFSELKSVSHGFASLSTAFMANEVSDLVKVEVDINYAPVDALTFIVHREDAPNMTQQLVANLKTTVPRQLYPTPVQARVEGKVIARVDVPPLRKNAAVNGEQHSTSKKAALLRRQSANKRRASKNTIKLPQSVFNAILSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U25</accession>
    <accession>F9URK0</accession>
    <name>PURL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="1">FGAR amidotransferase II</shortName>
            <shortName evidence="1">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purL</name>
        <name type="ordered locus">lp_2724</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645864.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890353.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U25"/>
    <dbReference type="SMR" id="Q88U25"/>
    <dbReference type="STRING" id="220668.lp_2724"/>
    <dbReference type="EnsemblBacteria" id="CCC79839">
        <property type="protein sequence ID" value="CCC79839"/>
        <property type="gene ID" value="lp_2724"/>
    </dbReference>
    <dbReference type="GeneID" id="57026099"/>
    <dbReference type="KEGG" id="lpl:lp_2724"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2279"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_9"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="PhylomeDB" id="Q88U25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2330-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100463" description="Phosphoribosylformylglycinamidine synthase subunit PurL">
        <location>
            <begin position="1"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <sequence length="739" mass="79706" checksum="E652859A496663A5" modified="2003-06-01" version="1">MLKKQPLSPTDVRDSKVYRDWGLTDAEYQLLTDKVLQRLPNETETGLFSGMWSEHCSYKNSKPVLKKFWTQGEQVLEGPGEGAGIIDIGDGQAVVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSMGARPIALLDSLRFGEPTDAHTKYLISQVVAGIGGYGNCIGIPTIGGDTVFDASYQKNPLVNAMCVGILDQADIQKGQATGIGNAVIYVGAKTGRDGINGASFASAEFNDANETQRSAVQVGDPFMEKLLMEACLEVIHEHRDVLIGIQDMGAAGLVSSSAEMASKAGSGLSLNLDLVPQRETGMTPFELMLSESQERMLLCVKAGAEAEIYQVFEKYGLDAVTIGKVTAGHQYQLFHHGKLVADVPVDALATKAPVYEREKKRPTRLNHQSHHQFMPRLVDATGTLKKMLQQPTIASKASLYGTYDSQVQTNTVVKPGSDAGVIRIRHTDKALAVTTDVNGRYLYLNPRVGGEIAVAEAARNIVASGGQPLGITDCLNYGNPEKPEQFYDLDESAMGIARACQLFNTPVISGNVSLNNESNGEAIYPTPMIGMVGLIKHQKDITTSDFKHAGDAVYVLGTTEADFNGSELQKMLTGTISGELFDFDLVTENRNQRLLLTAIQKGLVASAHDVSEGGLITTIAESCFPQNIGVELASDLPAANFFAETQSRFVISVTPAQQAAFESLMEPYVTYLGRTTATDRLHVQTADQAFDIKVSFAKQLWEGALPCLLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-07" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UH9</accession>
    <accession>F9UR36</accession>
    <name>Y2507_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein lp_2507</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2507</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642754.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UH9"/>
    <dbReference type="SMR" id="Q88UH9"/>
    <dbReference type="STRING" id="220668.lp_2507"/>
    <dbReference type="EnsemblBacteria" id="CCC79675">
        <property type="protein sequence ID" value="CCC79675"/>
        <property type="gene ID" value="lp_2507"/>
    </dbReference>
    <dbReference type="GeneID" id="57025939"/>
    <dbReference type="GeneID" id="66450226"/>
    <dbReference type="KEGG" id="lpl:lp_2507"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2112"/>
    <dbReference type="eggNOG" id="COG2848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048704_0_0_9"/>
    <dbReference type="OMA" id="EMAIGMV"/>
    <dbReference type="PhylomeDB" id="Q88UH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2167-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000070555" description="UPF0210 protein lp_2507">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <sequence length="447" mass="46590" checksum="204B51696B04C187" modified="2003-06-01" version="1">MESRSILETIQMVAEENLDIRTITMGISLFDCVDSDGERARQKIYDKITTSAKDLVKVAAQIQEEYGIPIINKRIAVTPIALIAAASQDQDYVAYAVTMERAAQALGVDLIGGFSALVQKGYQSGDRKLIASIPAALAATSRVCSSVNVGSTRAGINLDAVGEMGRIIKQIAADDPVNCMSLVVFANAVDDNPFMAGAFHGVGEADRVINVGISGPGVVKRALEEVRGQSIDIVSEQIKKTAFKVTRMGQFVGSIASERLHVPFGIVDLSLAPTPNEGDSVAEILEEIGLESVGAPGTTAALALLNDAVKKGGVMACEHVGGLSGAFIPVSEDAEMIRAVSAGRLNIEKLEAMTAVCSVGLDMIAVPGDTSAATISGMIADEAAIGMINNKTTAVRVIPATGKGVGDAVEFGGLFGQAPVMPVNTNQPTTFIKRGGHIPAPIHSFKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V80</accession>
    <accession>F9UQC7</accession>
    <name>MURD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="1">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murD</name>
        <name type="ordered locus">lp_2197</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644611.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889930.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V80"/>
    <dbReference type="SMR" id="Q88V80"/>
    <dbReference type="STRING" id="220668.lp_2197"/>
    <dbReference type="EnsemblBacteria" id="CCC79416">
        <property type="protein sequence ID" value="CCC79416"/>
        <property type="gene ID" value="lp_2197"/>
    </dbReference>
    <dbReference type="GeneID" id="57025725"/>
    <dbReference type="KEGG" id="lpl:lp_2197"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1857"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_1_9"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="PhylomeDB" id="Q88V80"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1877-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000109030" description="UDP-N-acetylmuramoylalanine--D-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <sequence length="459" mass="50137" checksum="083AB3E45C599DC9" modified="2003-06-01" version="1">MKSVEQYRNQKVLVLGLAKSGVNAARLLHKLGAFVTVNDKKKFDENPDAQELLSDGIKVITGGHPLSLLDEDFKVVVKNPGIPYSNPIVSGAQEKGIPVITEVELASQILAGELIGVTGTNGKTTTTTMITMMLNQRTNAGKAYVAGNIGVPASAIAQKATAADTMVTELSSFMLCGIQTLHPHIAVITNIYSTHLDYHGSRENYVKAKMRITMNQTANDYLVINWDSEEWRQLSKQSQATVVPFSRQANTKDGAYEEAGKLYFKDEYIMDAADIRIPGDHNVENALAAIAVAKLQAVPTAGIVQVLKTFTGVRHRTQYVETYQDRQFYNDSKATNLVSTEMALKGFDQPVILLAGGLDRGNTFEKLAPALKAHVKTLIVFGETAEKMADAGRLAGIQDIEFTDNCETAVPIAWQHSQAGDIIMLSPACASWDQYPNFEVRGDRFIKAIEQLTGKAEEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W95</accession>
    <accession>F9UPA8</accession>
    <name>GPSB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell cycle protein GpsB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guiding PBP1-shuttling protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsB</name>
        <name type="ordered locus">lp_1754</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms polymers through the coiled coil domains. Interacts with PBP1, MreC and EzrA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GpsB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638751.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W95"/>
    <dbReference type="SMR" id="Q88W95"/>
    <dbReference type="STRING" id="220668.lp_1754"/>
    <dbReference type="EnsemblBacteria" id="CCC79047">
        <property type="protein sequence ID" value="CCC79047"/>
        <property type="gene ID" value="lp_1754"/>
    </dbReference>
    <dbReference type="GeneID" id="49394007"/>
    <dbReference type="GeneID" id="57025375"/>
    <dbReference type="GeneID" id="66449610"/>
    <dbReference type="KEGG" id="lpl:lp_1754"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1480"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140309_1_0_9"/>
    <dbReference type="OMA" id="MEQVKYT"/>
    <dbReference type="PhylomeDB" id="Q88W95"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1510-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02011">
        <property type="entry name" value="GpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011229">
        <property type="entry name" value="Cell_cycle_GpsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794:SF1">
        <property type="entry name" value="PTHR35794:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029938">
        <property type="entry name" value="UCP029938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000337921" description="Cell cycle protein GpsB">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02011"/>
        </source>
    </evidence>
    <sequence length="113" mass="12926" checksum="916F281234FF70F8" modified="2003-06-01" version="1">MAKRNFTPKDILQKEFKPKMRGYDPADVDGFLDNVIKDYESFTKDNQQLSDENERLRAKVDELTKQVAVGATSPSSQPTSTVTNMDILKRLSNLERHVFGAQLDNNQNESHRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-10" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WJ7</accession>
    <accession>F9UP06</accession>
    <name>Y1634_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0122 protein lp_1634</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1634</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0122 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640380.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889459.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WJ7"/>
    <dbReference type="SMR" id="Q88WJ7"/>
    <dbReference type="STRING" id="220668.lp_1634"/>
    <dbReference type="EnsemblBacteria" id="CCC78945">
        <property type="protein sequence ID" value="CCC78945"/>
        <property type="gene ID" value="lp_1634"/>
    </dbReference>
    <dbReference type="GeneID" id="57025216"/>
    <dbReference type="GeneID" id="66449515"/>
    <dbReference type="KEGG" id="lpl:lp_1634"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1381"/>
    <dbReference type="eggNOG" id="COG2739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129218_1_0_9"/>
    <dbReference type="OMA" id="SIQEWQE"/>
    <dbReference type="PhylomeDB" id="Q88WJ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1408-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211868" description="UPF0122 protein lp_1634">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <sequence length="115" mass="13692" checksum="982897F9C3869FE6" modified="2003-06-01" version="1">MEIEKNYRINSLFEFYEPLLTNKQKAYIQLYYADDYSLGEIAAEFSVSRQAVYDNIKRTEKILEGYEAKLHLYHDFVERNHEVDAISDYIKQNYHGDTQLIKMIQQLVNLEADSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-30" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WM6</accession>
    <accession>F9UNX6</accession>
    <name>EX7S_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="1">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseB</name>
        <name type="ordered locus">lp_1601</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640351.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889429.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WM6"/>
    <dbReference type="SMR" id="Q88WM6"/>
    <dbReference type="STRING" id="220668.lp_1601"/>
    <dbReference type="EnsemblBacteria" id="CCC78915">
        <property type="protein sequence ID" value="CCC78915"/>
        <property type="gene ID" value="lp_1601"/>
    </dbReference>
    <dbReference type="GeneID" id="57025185"/>
    <dbReference type="GeneID" id="66449485"/>
    <dbReference type="KEGG" id="lpl:lp_1601"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1350"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_3_2_9"/>
    <dbReference type="OMA" id="PLNDYKG"/>
    <dbReference type="PhylomeDB" id="Q88WM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1377-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000206960" description="Exodeoxyribonuclease 7 small subunit">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <sequence length="76" mass="8451" checksum="9A9B66B178A1A394" modified="2003-05-30" version="1">MAEQPTFEQNLSQLETIVNQLEQGDVPLEQALDQFQKGVALSKQLQATLEGAEKTLTKMMNENGDEVPFEQADANE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WV3</accession>
    <accession>F9UNP7</accession>
    <name>COAE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">lp_1510</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101452.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889350.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WV3"/>
    <dbReference type="SMR" id="Q88WV3"/>
    <dbReference type="STRING" id="220668.lp_1510"/>
    <dbReference type="PRIDE" id="Q88WV3"/>
    <dbReference type="EnsemblBacteria" id="CCC78836">
        <property type="protein sequence ID" value="CCC78836"/>
        <property type="gene ID" value="lp_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1510"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1270"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_0_9"/>
    <dbReference type="PhylomeDB" id="Q88WV3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1297-MON"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000172953" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <sequence length="197" mass="21273" checksum="CFD1531A14A615DD" modified="2003-10-31" version="2">MTKLIGLTGGIATGKSTVSKLLATKLPIVDADKIAWQVEGPGQPTTQKIVAHFGQQAVLADGRLNRPWLGQLVFNDAQALQALTAITRLPIQYAMFEAIVAANQQQPDAIILDVPLLFESGWQHVCDQVLVVTASPAVVLQRLMARNHLSQQAAQARIDSQMPLAQKVARADVVIDNGANIDKTKAAVLKWLKTITK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XQ4</accession>
    <accession>F9UMU2</accession>
    <name>XPT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name type="ordered locus">lp_1139</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889045.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XQ4"/>
    <dbReference type="SMR" id="Q88XQ4"/>
    <dbReference type="STRING" id="220668.lp_1139"/>
    <dbReference type="EnsemblBacteria" id="CCC78531">
        <property type="protein sequence ID" value="CCC78531"/>
        <property type="gene ID" value="lp_1139"/>
    </dbReference>
    <dbReference type="GeneID" id="57024777"/>
    <dbReference type="GeneID" id="66449030"/>
    <dbReference type="KEGG" id="lpl:lp_1139"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.962"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099015_0_0_9"/>
    <dbReference type="OMA" id="HQVDPVL"/>
    <dbReference type="PhylomeDB" id="Q88XQ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-973-MON"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000339709" description="Xanthine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <sequence length="195" mass="21454" checksum="E5AA0D5CB67B5E20" modified="2003-06-01" version="1">MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESSGIAPAVMAGLAMHVPVVFARKHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQVLLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQTGHQLIADRGVRLESLAQITSFDGDRVHFASEDTQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XU7</accession>
    <accession>F9UMP5</accession>
    <name>RS9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsI</name>
        <name type="ordered locus">lp_1078</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888998.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XU7"/>
    <dbReference type="SMR" id="Q88XU7"/>
    <dbReference type="STRING" id="220668.lp_1078"/>
    <dbReference type="EnsemblBacteria" id="CCC78484">
        <property type="protein sequence ID" value="CCC78484"/>
        <property type="gene ID" value="lp_1078"/>
    </dbReference>
    <dbReference type="GeneID" id="49393356"/>
    <dbReference type="GeneID" id="57024730"/>
    <dbReference type="GeneID" id="66448986"/>
    <dbReference type="KEGG" id="lpl:lp_1078"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.913"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_9"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="PhylomeDB" id="Q88XU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-927-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000111367" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="130" mass="14595" checksum="79098003638E71A5" modified="2003-06-01" version="1">MAQVQYRGTGRRKDSVARVRLVPGTGKIVMNDKSVEDYIPFADIRKELLQPFEVTETTDQYDVLVNVNGGGFHGQAGATRHGIARALLEVDPDFRTPLKRAGLLTRDARMKERKKPGLKKARKASQFSKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YM8</accession>
    <accession>F9ULV6</accession>
    <name>REX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rex</name>
        <name type="ordered locus">lp_0725</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640983.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YM8"/>
    <dbReference type="SMR" id="Q88YM8"/>
    <dbReference type="STRING" id="220668.lp_0725"/>
    <dbReference type="EnsemblBacteria" id="CCC78195">
        <property type="protein sequence ID" value="CCC78195"/>
        <property type="gene ID" value="lp_0725"/>
    </dbReference>
    <dbReference type="GeneID" id="57024430"/>
    <dbReference type="GeneID" id="66448698"/>
    <dbReference type="KEGG" id="lpl:lp_0725"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.610"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_1_1_9"/>
    <dbReference type="OMA" id="HEQRKAG"/>
    <dbReference type="PhylomeDB" id="Q88YM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-630-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000097895" description="Redox-sensing transcriptional repressor Rex">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <sequence length="225" mass="25214" checksum="70F95416513EDA89" modified="2003-06-01" version="1">MAETKIPRATAKRLPIYYRYLNILLDADKKRVSSTELSEAVKVDSATIRRDFSYFGALGKRGYGYDVETLLAFFKKILNQDTLTNVALIGVGNLGHALLNFNFHKNSNVRISAAFDVNEAIANTVQSGVPVYPMTELKKQLIEQQIEIAILTVPTTVVQKITDDLVDANVKGIMNFTPLRISVPETVRVQNVDLTNELQTLIYFIEHYGQQLGDNGNDDENETED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YP9</accession>
    <accession>F9ULT5</accession>
    <name>Y699_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein lp_0699</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0699</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YP9"/>
    <dbReference type="SMR" id="Q88YP9"/>
    <dbReference type="STRING" id="220668.lp_0699"/>
    <dbReference type="EnsemblBacteria" id="CCC78174">
        <property type="protein sequence ID" value="CCC78174"/>
        <property type="gene ID" value="lp_0699"/>
    </dbReference>
    <dbReference type="GeneID" id="57024409"/>
    <dbReference type="GeneID" id="66448677"/>
    <dbReference type="KEGG" id="lpl:lp_0699"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.587"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_1_9"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="PhylomeDB" id="Q88YP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-609-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000170402" description="Nucleoid-associated protein lp_0699">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="102" mass="11240" checksum="FB5DA49E16201472" modified="2003-06-01" version="1">MMRGMGNMQSMMKQMKKMQAQMTAEQAALNEQTFTGAAPDDMVKVTFTGDKKMKDITINPDAVDPDDVDMLQDLVVAAVNDALTKVDEQTQSTMGKYTKGLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z10</accession>
    <accession>F9UL41</accession>
    <name>SPRTL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SprT-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0570</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SprT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888570.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z10"/>
    <dbReference type="STRING" id="220668.lp_0570"/>
    <dbReference type="EnsemblBacteria" id="CCC78056">
        <property type="protein sequence ID" value="CCC78056"/>
        <property type="gene ID" value="lp_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0570"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.474"/>
    <dbReference type="eggNOG" id="COG3091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123820_0_0_9"/>
    <dbReference type="OMA" id="LVHYHLH"/>
    <dbReference type="PhylomeDB" id="Q88Z10"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-486-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00745">
        <property type="entry name" value="SprT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023524">
        <property type="entry name" value="Uncharacterised_SprT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000213291" description="Protein SprT-like">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00745"/>
        </source>
    </evidence>
    <sequence length="148" mass="17616" checksum="40DA4A62305639F4" modified="2003-06-01" version="1">MTDLELQQLVATISMHDFHRPFQHRAYFNARLRTTGGRYQLASHDIDINPKMLTDFDEATLIGVIKHELCHYHLHLTKRGYRHRDADFKRLLAQVGGSRYAPAPKQATARPYRYIYECQRCGRRYYRKRRMDTRRYTCGRCQGPIKLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z54</accession>
    <accession>F9UKY7</accession>
    <name>MURA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase 2</fullName>
            <shortName evidence="1">EPT 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA2</name>
        <name type="ordered locus">lp_0510</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z54"/>
    <dbReference type="SMR" id="Q88Z54"/>
    <dbReference type="STRING" id="220668.lp_0510"/>
    <dbReference type="EnsemblBacteria" id="CCC78002">
        <property type="protein sequence ID" value="CCC78002"/>
        <property type="gene ID" value="lp_0510"/>
    </dbReference>
    <dbReference type="GeneID" id="57024283"/>
    <dbReference type="GeneID" id="66448558"/>
    <dbReference type="KEGG" id="lpl:lp_0510"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.419"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_9"/>
    <dbReference type="OMA" id="CRFGQRN"/>
    <dbReference type="PhylomeDB" id="Q88Z54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-423-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000178882" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="426" mass="45830" checksum="0BE56809381EBC0D" modified="2003-06-01" version="1">MKKMIIHGGKRLSGELTIGGAKNSTVALIPAAILADTPVQFDTVPHILDVHNLRLILESMNVHSTFENDVLTIDPTNIEESELPSHAIKSLRASYYFMGALLGRFNRATVTFPGGDNIGPRPIDQHIKGFKALGANVVEENDSVFISTGTEGLHGARIFLDVVSVGATINIILAAVKAHGTTTIENAAKEPEIIDLATFLNNMGAKIRGAGTDVIRIEGVPALHSRATHTIIPDRIETGTYLSLAASIGDGILLKNVIPEHMESFTAKLVEMGVDLQINEDSIYVPRSNDLDPIRVKTMTYPGFATDLQQPITPLLLRANGSSVVIDTIYPQRTQHVEQLRKMGADIRVQDNLIVVGHSSHLQGAHVEAGEIRSGAALMIAGLAASGVTEISRADNILRGYDRVIDKLHTLGADVEIAADEEVPEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z60</accession>
    <accession>F9UKY1</accession>
    <name>SYS1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase 1</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase 1</fullName>
            <shortName evidence="1">SerRS 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS1</name>
        <name type="ordered locus">lp_0501</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888510.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z60"/>
    <dbReference type="SMR" id="Q88Z60"/>
    <dbReference type="STRING" id="220668.lp_0501"/>
    <dbReference type="EnsemblBacteria" id="CCC77996">
        <property type="protein sequence ID" value="CCC77996"/>
        <property type="gene ID" value="lp_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0501"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.413"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_9"/>
    <dbReference type="OMA" id="QMYNINY"/>
    <dbReference type="PhylomeDB" id="Q88Z60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-417-MON"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122065" description="Serine--tRNA ligase 1">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="423" mass="47785" checksum="391CFDDA0EFB0D95" modified="2003-06-01" version="1">MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIGQSDPQSEAGQALIQQVKQLNGDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDSNVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAGARFVYYKDAGALLERAVYSFMLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYYANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELEKLTDNAEEVLRELGLAYHVIKLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQQADGTVKIPKVLQPYMHGMTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZC9</accession>
    <name>Q88ZC9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">valT</name>
        <name evidence="9" type="ordered locus">lp_0399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100994.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888423.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77909">
        <property type="protein sequence ID" value="CCC77909"/>
        <property type="gene ID" value="lp_0399"/>
    </dbReference>
    <dbReference type="GeneID" id="57024208"/>
    <dbReference type="KEGG" id="lpl:lp_0399"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.331"/>
    <dbReference type="eggNOG" id="COG1114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036807_0_1_9"/>
    <dbReference type="OMA" id="IMIVCAK"/>
    <dbReference type="PhylomeDB" id="Q88ZC9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-332-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="458" mass="49387" checksum="D1C52651BEE8006B" modified="2003-06-01" version="1">MQITRKLTIKHYIIIGSMLFGMFFGAGNLIFPIHLGQLAGANWLTAGWGFLLTGTLLPLLGIIAISVTHSSGIYELARPIGKRYATIFMVLTCATLGPLFATPRTATTPFQIGIASHVSSAQAQWYLLAYSLIFFSITYWAARRPTRIVDTIGKLLNPAFLILLALIFGIAFSRPLGTTNATPTAAYQHGAFLNGFLQGYNTMDALAALLFGIAVVTTIRGLGQRDAGAIAKTAAKSSLLSISLEAVIYLGLIWIGATSLSQFKLSADGGIAFGQIANAFMGTPGAIVLAIMATLTCLTTAVGLATSFAEALHAKFPKISYRAWNRLACGASFLIANIGLDQIIAWSTPMLMFLYPLAITLIILAIASPLFHRDPLVYRWTTALTLIPAFIDGLGAAPALITRLGWVQTILAWDQRYLPLAKLGFDWALPAIIGLLIGLGWHYARRFQNAHAYKMSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ9</accession>
    <name>F9UKZ9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888528.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0524"/>
    <dbReference type="EnsemblBacteria" id="CCC78014">
        <property type="protein sequence ID" value="CCC78014"/>
        <property type="gene ID" value="lp_0524"/>
    </dbReference>
    <dbReference type="GeneID" id="49392855"/>
    <dbReference type="GeneID" id="57024295"/>
    <dbReference type="GeneID" id="66448570"/>
    <dbReference type="KEGG" id="lpl:lp_0524"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.432"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_0_9"/>
    <dbReference type="OMA" id="NDIGNQY"/>
    <dbReference type="PhylomeDB" id="F9UKZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-435-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="130" mass="14468" checksum="8FC8CDE0A760B82F" modified="2011-10-19" version="1">MAAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMPTHVNINAAHTGIEKNSVVLLEQIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRTRRRPQRTFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL51</accession>
    <name>F9UL51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase NpsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">npsB</name>
        <name evidence="7" type="ordered locus">lp_0581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101063.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0581"/>
    <dbReference type="DNASU" id="1061536"/>
    <dbReference type="EnsemblBacteria" id="CCC78066">
        <property type="protein sequence ID" value="CCC78066"/>
        <property type="gene ID" value="lp_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0581"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.484"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_9"/>
    <dbReference type="PhylomeDB" id="F9UL51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-497-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="476"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="805" mass="91790" checksum="2918D4EF6683A443" modified="2011-10-19" version="1">MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRLPRGVKFTVMVLALTKMKITFIPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNSSKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKEDYQLTTDDRVASFTPYSFVVSYYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMRLLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDDQQRVLPHGSVGELFIYGVQVTNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNGELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYLAVKANCIYCWVTSAKAIDESQILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRENEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHPVLADMAALLSQKNVFKAIYTFVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFPIYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKREINLMGWSYGGVVASEMCYQLEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTERLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDYLFVHESSRSLIQDVLGLAAKVVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULF1</accession>
    <name>F9ULF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, AraC family, GlcNAc-like induced</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaR</name>
        <name evidence="4" type="ordered locus">lp_3597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3597"/>
    <dbReference type="DNASU" id="1062084"/>
    <dbReference type="EnsemblBacteria" id="CCC80558">
        <property type="protein sequence ID" value="CCC80558"/>
        <property type="gene ID" value="lp_3597"/>
    </dbReference>
    <dbReference type="GeneID" id="66451031"/>
    <dbReference type="KEGG" id="lpl:lp_3597"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3002"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="OMA" id="CKYTTIR"/>
    <dbReference type="PhylomeDB" id="F9ULF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3045-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="37956" checksum="5C3B5B53BE909721" modified="2011-10-19" version="1">MNTRILNALKQTTLIEEKQKASHCFVEDMPPYAINQELSLKEHGRVLSNYFFKNKDIYISRHNRYADYPTHTHTFLEMNYMLQGHATEIVDDKKITLNTGDLLLLDEGSTHSIKALGDNDLLINILFRTKNISINLLNDLRRSNNIFYDFLLSQVIEDSNHKRDYLVFTKKRNNEVQETLDRIIDEYYLKRDFSNSIIKSYLSILLVQLVREYPLNGPHQENKSSLLAIKVLKAIAEEYKTVSLEELANRYNYNKNYLSNIFKSEVGQTFSEVLTRQRLIQAHTLIASTSLPIATIMEQVGIKNKTFFYQKYKNYYKTLPSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH1</accession>
    <name>F9ULH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, glucitol/sorbitol-specific EIIC component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts37C</name>
        <name evidence="2" type="ordered locus">lp_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891092.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3620"/>
    <dbReference type="EnsemblBacteria" id="CCC80578">
        <property type="protein sequence ID" value="CCC80578"/>
        <property type="gene ID" value="lp_3620"/>
    </dbReference>
    <dbReference type="GeneID" id="66451054"/>
    <dbReference type="KEGG" id="lpl:lp_3620"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3022"/>
    <dbReference type="eggNOG" id="COG3730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093147_0_0_9"/>
    <dbReference type="OMA" id="HINPGEY"/>
    <dbReference type="PhylomeDB" id="F9ULH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3065-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004699">
        <property type="entry name" value="PTS_IID_sorb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40399">
        <property type="entry name" value="PTHR40399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03608">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038321">
        <property type="entry name" value="PTS_glc_srb_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00821">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51107">
        <property type="entry name" value="PTS_EIIC_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="20786" checksum="73CE8262B445CDD7" modified="2011-10-19" version="1">MKIITDFASGFMGLFQTGGKTFISWMSSIVPVVLLLLVLMNTIIAFLGEERMNKLAMASAKNPVTRYMILPFLAAFMLGNPMAFTMGRFLPEFYKPSFYASQAQFCHTSNGVFPHINPGELFIWLGIAQGVQKLGLNTMDLAIRYLLVGLIMNFVGGWVTDFTTAYVCRTSGVKLSKQVDVSLTPDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK4</accession>
    <name>F9ULK4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sorbitol-6-phosphate 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srlD2</name>
        <name evidence="2" type="ordered locus">lp_3657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646226.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9ULK4"/>
    <dbReference type="STRING" id="220668.lp_3657"/>
    <dbReference type="EnsemblBacteria" id="CCC80611">
        <property type="protein sequence ID" value="CCC80611"/>
        <property type="gene ID" value="lp_3657"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3657"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3055"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_9"/>
    <dbReference type="OMA" id="FSSISYM"/>
    <dbReference type="PhylomeDB" id="F9ULK4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3098-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="28661" checksum="77875EC108A3399F" modified="2011-10-19" version="1">MNNSWINISGKVYVVTGGSSGIGKAIVTELLNNGAIVYNADLNQGDQQNDNLHFVETNVTDAEAVNRLVLKVVDEQGKIDGLVNNAGINLPRLLADAKDPHGKYEFAESDFVKMFAVNVKSVFLVSQAVTHQFEKQQYGVIVNMSSEAGLEGSQGQSVYSATKGAINGFTRSWAKELGEHNIRVVGVAPGIMEATGLRTRSYEEALAYTRHKTVDDIRAGYKSTSTTPLGRSGKLSEVADAVNYLLSERASYITGVTINVAGGKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN3</accession>
    <name>F9ULN3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101095.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888636.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0644"/>
    <dbReference type="EnsemblBacteria" id="CCC78122">
        <property type="protein sequence ID" value="CCC78122"/>
        <property type="gene ID" value="lp_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0644"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.538"/>
    <dbReference type="HOGENOM" id="CLU_2369312_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-555-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="95" mass="10875" checksum="DAF85B6A807825EB" modified="2011-10-19" version="1">MNWGNQLVKLAANHAYEPAALHWTKQRMKRHLKTGGSAQDEVCAHEYKLFALEVLIIEYQRDGLNFDLNQCWGKPAEYFIDLEQARQGLQTGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR3</accession>
    <name>F9ULR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 52, endolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888666.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0675"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78152">
        <property type="protein sequence ID" value="CCC78152"/>
        <property type="gene ID" value="lp_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0675"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.567"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4926">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028587_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-586-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007119">
        <property type="entry name" value="Phage_minor_struct_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010572">
        <property type="entry name" value="Prophage_Tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06605">
        <property type="entry name" value="Prophage_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01665">
        <property type="entry name" value="put_anti_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tail" evidence="3">
        <location>
            <begin position="158"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="624" mass="71361" checksum="0E9E549DF8955B0B" modified="2011-10-19" version="1">MYKILVRETYRGNEEAINEPDVYGNRIVSGSLSLVSGGIDTGTLAISLENTLFNRILPYRWFIRIEDLQTKETIFRGRFIKVSKVYSTTHTQTLSFESELAYLHDSAQVYREIHNTSVNDFLQIIIDEHNRQVDDFKKITLGTIDVINSTDNVYRYLDETKDTLDNITDKLVNRLGGFLRIGRNPHSQLILDYVNRLGTDTKQTIELGVNLKSFTRDLNVNNLITRLVPLGAEKAQKDDQRDSNKPIPKIDISSVNNGSRYLDDPKLIDKFGIIQKVNVWDDVHDARILKTKGEQYLKEQVSAEIAWSVDIVNLALIDKRFQSFAVGNSYRIIDKFMDIDETISVSEKEVDLVNPQTVTIKIGNQNKKLTSQQINQIRIINQLKKFSEYITSFNTQNNVPDSPNGSQPNQPHDKPHDQPHDQPSYYNGAIVDVSEFQSDINWSQVRNAGLALGVIRIQDGENYIDVKHVKNLQGVLANNLNYAVYAFFRGVNEADSQAEARAFYQRVQNVVKGQQQPRFYALDIEAIENNNMRGTVNAYISQLNDLGILNSQIVLYIANHLYQQLNLDTTKVGSIWIPSYGTKPRYPYDLWQYTDKGTLAGIPTKVDMSQDPSTRFKNQYLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULT9</accession>
    <name>F9ULT9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0704"/>
    <dbReference type="EnsemblBacteria" id="CCC78178">
        <property type="protein sequence ID" value="CCC78178"/>
        <property type="gene ID" value="lp_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="57024413"/>
    <dbReference type="GeneID" id="66448682"/>
    <dbReference type="KEGG" id="lpl:lp_0704"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.591"/>
    <dbReference type="eggNOG" id="COG3870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143974_1_0_9"/>
    <dbReference type="OMA" id="TFMIGIE"/>
    <dbReference type="PhylomeDB" id="F9ULT9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-613-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12004" checksum="AEB0931BF52A1B96" modified="2011-10-19" version="1">MKLIIAIVQDKDSNRLSSQFIEANVRATKLSTTGGFLRSGNTTFMIGIDDDRVDEVLAMIKETSHAREQFMTPPVNLDVTMDGAAAYPVEVQVGGATVFVLPIEQFHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV0</accession>
    <name>F9ULV0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonates ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnD</name>
        <name evidence="2" type="ordered locus">lp_0715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888703.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0715"/>
    <dbReference type="EnsemblBacteria" id="CCC78189">
        <property type="protein sequence ID" value="CCC78189"/>
        <property type="gene ID" value="lp_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0715"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.602"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810724_0_0_9"/>
    <dbReference type="OMA" id="QGMRFDK"/>
    <dbReference type="PhylomeDB" id="F9ULV0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-624-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388823" evidence="1">
        <location>
            <begin position="31"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="350" mass="37571" checksum="91AFDE3B3BA67F71" modified="2011-10-19" version="1">MSKVSKSLLGLSFISVLGLGLAGCASGTSAKSGGSSTDSSKTITVVFYPNESAKSFAGSRTAIKQAVEKATGKTVKLQTTTDYNVAIQAIASGKAQVAYMGANGYIQAHHKSKDVVPFAAQSDAKGTLKDATYNSYLMVQQKDAKKYEENGKYSIKNVKGKKMSYVSNSSTSGFLVPTAEISREFNIKTADQDKLTQSGSFFSKVLYGGSHQGSAVNLIKGDADVAAFDDADLMPYLNVTKGSWDKVGSTFTVKDNAEAPFTSLAGKSVVNIAMMPVQQGPWVYNTKALSKDDQKKIATEFTSKSFAQNKKIFSEPNAKTPMMFPKKSEKSKLVNVTDKWYAPTHKLVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM01</accession>
    <name>F9UM01_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101155.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888754.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0778"/>
    <dbReference type="EnsemblBacteria" id="CCC78240">
        <property type="protein sequence ID" value="CCC78240"/>
        <property type="gene ID" value="lp_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0778"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.657"/>
    <dbReference type="eggNOG" id="COG3247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091585_7_0_9"/>
    <dbReference type="OMA" id="GITHIVY"/>
    <dbReference type="PhylomeDB" id="F9UM01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-675-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="178" mass="19833" checksum="68F98CD1C0A99469" modified="2011-10-19" version="1">MFNDHRWGFDWTEFMTGIVFLIAAYFVIKQPQAALLSLVFLFAIAAIISGVTTIGGYTKLRRETGLRANFALVFAIIDILVGLLFLFHAPTGVLVLGYVFAFWFLIDSIERLTVVSHLRVFGTGYFVLSLILDIISLALGILLVINPMIAVISFNVLVSFYFAVFGINAILIAFARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM58</accession>
    <name>F9UM58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppx3</name>
        <name evidence="3" type="ordered locus">lp_0843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888811.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0843"/>
    <dbReference type="DNASU" id="1061835"/>
    <dbReference type="EnsemblBacteria" id="CCC78297">
        <property type="protein sequence ID" value="CCC78297"/>
        <property type="gene ID" value="lp_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="57024539"/>
    <dbReference type="KEGG" id="lpl:lp_0843"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.717"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_4_1_9"/>
    <dbReference type="OMA" id="FWHMLPP"/>
    <dbReference type="PhylomeDB" id="F9UM58"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-733-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="354"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="509" mass="58096" checksum="A26537E5B9F01827" modified="2011-10-19" version="1">MAAKLFGIMMINVQSIELSIVNLRTLRQVERVRSDVSLGEDIYDQHTIDYDSVEQAAQALSGFVQIMNDYGVKDYHLWGSWSLSSANNADYIQDQLLVRTGLKIDWLSSSQETYLRSVAVAVHFPRFKQMITKPTYLLGINSGSVGISHYDQSNFVFSRSLRLGPVRIAEVLEDLQSSVPNYVEVLDDYISSQIVDFGRFLPGRRDQPSNVVMLGVAPFATLFRQQQSKAGVEELSKADFQALYEDVLNASDQYLMDKYEVDEEDVRLIVPELLLINELLQLTNAEKIWLGNVTVLDGLIIQEAIKLGYKKYNFNDQIVTAAKNIADRYNVEPKHRDLVTKFSLHLFDQLKPLHHLGKRERLLLQVAAIVHDVGSYIDPHQHYLHSDYILQATELMGLTDTEKRMVALISRYHSAQTPSKDIRHFGHLQVEQRLLVSKLSAILRIADALDDGRKQKIDKISVSIRNPRVIITCFAHDDLFLENWVFAQKAEFFKEVFGLTPVIKLRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM92</accession>
    <name>F9UM92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine transporter, APC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888845.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0888"/>
    <dbReference type="EnsemblBacteria" id="CCC78331">
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        <property type="gene ID" value="lp_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="57024572"/>
    <dbReference type="GeneID" id="66448835"/>
    <dbReference type="KEGG" id="lpl:lp_0888"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.752"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="377"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="443" mass="47687" checksum="84A9C964078AC33E" modified="2011-10-19" version="1">MQETKQATTLNRSLGFWSALSLVVGTVIGSGIFFKQSSVLDSAGSPSAALLAWLLGGLITLTAGLTIAEVGAQMPHTGGLYVYMEQIYGKLWGFLSGWMQIAVYGPAIIASISAYLGILLVGFFNLQAGWQAPLSIGVIVLIGILNMFENRWGAAFQIATTLGKLLPIAAIIIFGLFYGNQNALGQSLHTITQSTGSFGVAVLATLFAYDGWILVANLGGEIKNPQKLLPQAIILGISMVLIAYTLVSYGILHFVPAATIHKLGQQTTLYFAQAAFGTIGGRLLNIGIIISMVGCLNGKIMTFPRIVYAMAAQNQLPFAKQLSYLHKKSHEPIAATIAILVYASIMILFFNPDRLSDLCIFTVYCFYVATFVGVFILRKRRPASERPFSTPGFPITPLIAILGALFVIISEIGSDLSGVLISLVIVAVGFPIYYWKQQQNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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        <name evidence="2" type="ordered locus">lp_0904</name>
    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888860.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_0904"/>
    <dbReference type="EnsemblBacteria" id="CCC78346">
        <property type="protein sequence ID" value="CCC78346"/>
        <property type="gene ID" value="lp_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="57024587"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="171"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="32531" checksum="D66A2023A92CECD5" modified="2011-10-19" version="1">MRIKKVLNNNAFITHNDDHQEMIVIGKAIAYGKHFNDTVDESKVYKMFTPISRGDRKLILDMVNEIPIQYFQIAKQIVDKAESDENIELTDSVYIALTDHISSSVDRIKSGLMLTNQFLWEIRSYYPKEYQIGQWAIQLINGTCDVTLPDDEAGFIAIHIISGELGEQLDEFHEIINFIKKITSIVTYQLSVEIDRDSLDYNRFVTHLKFFWQYMMENDKKHTIGDLSDEMLAIIKGKKVAAYECALKVRDFVQKTYHYTLNNEDLLYMTIHIARIADAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV4</accession>
    <name>F9UMV4_LACPL</name>
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        <submittedName>
            <fullName evidence="6">Cation transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889057.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1154"/>
    <dbReference type="EnsemblBacteria" id="CCC78543">
        <property type="protein sequence ID" value="CCC78543"/>
        <property type="gene ID" value="lp_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1154"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.974"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_5_1_9"/>
    <dbReference type="OMA" id="YVKKSWQ"/>
    <dbReference type="PhylomeDB" id="F9UMV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-985-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="779" mass="85080" checksum="A33E11DEA39BB000" modified="2011-10-19" version="1">MSERYLSAIEHGLTTKQVDQRLTAGLKNEPLPPLTRSVKQIFRDNLLTLFNCINVLLAGLVFLTGSYKNMLFLFVVIVNTAIGIFQEIRAKRQVDKLALLSATKVQVRRDGQTVAIGQDEIVQDDLLLVTRGEQIPVDGLVRATAGLEVDESQITGEADPVIKGPGDELVSGSVILGGHGIVQATQVGHGSFIKQMARAAKQKRRTPSQLLTIINRIIKILTFTIIPLGAGLFISTMMRGESQNRAILGTVAAMVGMIPEGLVLLTSVALAAGAFTLGRHQVLVRELPAIEALARVDTLCLDKTGTITSGKLVFERVEPWNQHDLTAVEHRLAALVTAIDDDNETARAIKTAFGQPPVQATEVLPFSSSRKWSGAAFDGHAYVMGAPEFIFTTVPGELQSRIKTLAQQGYRVLVLAEVAALTTPKPTRPMTLGLILITDELRPHAKTTFGFFANQDVALKVISGDNPVTVASIAQRAEIKDADRLVDMSQVGTTPDYDQLVTNYTVFGRVTPQQKEQLIKAYQRNGHTVAMTGDGVNDLLALKQADCSIAMASGSEATKSLADFVLIDSNFDAMVQVLNEGRRVINNIERVAALYLIKTMYSVALTLIFIFMSHSYPFEPIQLTPISSLMVGIPTFFLALQPDYTRITGRFMKQVMEIAVPAAICVVGYIMVIMVLGNKFQLNFETTATLSVLMTGIFSLNALLIAARPLNRFKIGLVVLMATLFVLVFLFAGRIFSLVNLLDWSLAVIYLPLMISAYPVFIVLQNGLGKRVLSKINWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW9</accession>
    <name>F9UMW9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gdh</name>
        <name evidence="10" type="ordered locus">lp_1169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889072.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1169"/>
    <dbReference type="EnsemblBacteria" id="CCC78558">
        <property type="protein sequence ID" value="CCC78558"/>
        <property type="gene ID" value="lp_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1169"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.988"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_9"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="PhylomeDB" id="F9UMW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1001-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="205"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="48642" checksum="6F98E593C7C5FECA" modified="2011-10-19" version="1">MSQATDYVQHVYQVIEHRDPNQTEFLEAINDVFKTITPVLEQHPEYIEANILERLTEPERIIQFRVPWLDDAGHARVNRGFRVQFNSAIGPYKGGLRLHPSVNLSIVKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELSKYIGLDTDVPAGDIGVGGREIGFLYGQYKRLRGADRGVLTGKGLNYGGSLARTEATGYGLAYYTNEMLKANQLSFPGQRVAISGAGNVAIYAIQKVEELGGKVITCSDSNGYVIDENGIDFKIVKQIKEVERGRIKDYADRVASASYYEGSVWDAQVAYDIALPCATQNEISGDQAKNLIANGAKVVAEGANMPSSPEAIATYQAASLLYGPAKAANAGGVAVSALEMSQNSMRLSWTFEEVDNRLKQIMQDIFAHSVAAADEYHVSGDYLSGANIAGFTKVADAMLAQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY3</accession>
    <name>F9UMY3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps1I</name>
        <name evidence="2" type="ordered locus">lp_1185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1185"/>
    <dbReference type="DNASU" id="1063148"/>
    <dbReference type="EnsemblBacteria" id="CCC78572">
        <property type="protein sequence ID" value="CCC78572"/>
        <property type="gene ID" value="lp_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1185"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1003"/>
    <dbReference type="HOGENOM" id="CLU_711320_0_0_9"/>
    <dbReference type="OMA" id="SSEMGEY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1015-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="388" mass="44349" checksum="C45D417A871978F8" modified="2011-10-19" version="1">MLLTHSTGNKTSQVESVREKFFFLLYAAYEITYYIFGQSTINTFFNTSSITFSVNLLVIIGLTFFVATNKYDLIQFVLIFVGIIMGLYAYSVLRLNVLLITVLFMAAAKNIHLNQFIQKDFMLRTILLVGIILANRLGFVPSNTGLRVGTITIVRDSLGFGQFNITGALIMICVLEYVYLNFQRMTSLAYQWIVIIIVLTLALTNSRGSMLAATLYTLASWLFQHHNKEARYWTKKLIGYAKYMFGFLTVVSTIAVVLFSYKSTMWQFINKVTSDRINILNQYYEKFGIHILPQQVTNYRSAGIIVMDNIYVTLAIQYGLIVILLFVIYYYIVCAEALKKNNIQFILMLVALMIFGIIESSFFIVGINFTVMMIFSNMSVMPNSSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ4</accession>
    <name>F9UMZ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101297.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889097.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1196"/>
    <dbReference type="DNASU" id="1063114"/>
    <dbReference type="EnsemblBacteria" id="CCC78583">
        <property type="protein sequence ID" value="CCC78583"/>
        <property type="gene ID" value="lp_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1196"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1014"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_33_1_9"/>
    <dbReference type="OMA" id="IWAIRVR"/>
    <dbReference type="PhylomeDB" id="F9UMZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1026-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
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        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22984" checksum="47F61C57F1284770" modified="2011-10-19" version="1">MINIYYNVEPLRSNEEITDFVNKARNGTHGERNALLILIGLNTGLRMSDILNLKVGQIRYHDIVHITEKKTKKRRVILLTRLRPQINHYIKDLPDNEYLFTNRQHQPLSVNAVYKLFQTIARKMHRTDIGTHTLRKTFGYHYYQQTHDIGTLMMIFNHSNEAITKRYIGLNQDVILKQMAGFQLGLEYEKATNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN35</accession>
    <name>F9UN35_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein, NlpC/P60 family,gamma-D-glutamate-meso-diaminopimelate muropeptidase</fullName>
            <ecNumber evidence="4">3.4.19.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78624">
        <property type="protein sequence ID" value="CCC78624"/>
        <property type="gene ID" value="lp_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1242"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1054"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056866_0_0_9"/>
    <dbReference type="OMA" id="NTTWHAT"/>
    <dbReference type="PhylomeDB" id="F9UN35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1065-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388046" evidence="2">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="243" mass="27078" checksum="08A2CAD257C49827" modified="2011-10-19" version="1">MKQRLITLIVAILGLTVGLWQAPNIDASSTNRVIKTTNLTKSAYLTKNTQDGFYNMSGAANNLKIQSRGTLRQYGNTTWFVTQQRQIRLANNTTANYYFITSANTRVRGWVKTGSLKKSTRSFTNLYNVAKSKLGHRYVYGAVGPNTFDCSGYTKYVFQQAAQKTLPRVAQAQYRQYPKISKQRAQKGDLVFFGSGTGSISHVGIYVGGGKMIDAQDNGVKNEKVYVPWWHAVGYSRPVNFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN49</accession>
    <name>F9UN49_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_1259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889152.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1259"/>
    <dbReference type="EnsemblBacteria" id="CCC78638">
        <property type="protein sequence ID" value="CCC78638"/>
        <property type="gene ID" value="lp_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1259"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1068"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_9"/>
    <dbReference type="OMA" id="FSATQMF"/>
    <dbReference type="PhylomeDB" id="F9UN49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1079-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="281" mass="29500" checksum="F30E23AA1ABAE650" modified="2011-10-19" version="1">MIYSLGLMLGVGVIAGIFGAILGIGGGMIVTPILTLGLGLDIKYAIGASIIAVIATSSGSTIAYLRDEMLNLRVAMFLEIATTVGAVLGAVLTGVLNATFLYFLFGALLVFTTYNMIRKLMSKNGELPSVKDDKLATQLNLNGTYYDKALNKQVDYQVENVPGGFSMMFGAGFASGLLGIGSGAFKVLAMDTIMHMPLKPSSATSNLMMGVTAAASAMIYFFNGSIKPGIAAPLAIGIIVGALIGSRIMTRLKPRLIRMIFVPVMLYLGIQMIAKGFGVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC0</accession>
    <name>F9UNC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system histidine protein kinase sensor protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pltK</name>
        <name evidence="3" type="ordered locus">lp_1355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101370.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889223.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1355"/>
    <dbReference type="EnsemblBacteria" id="CCC78709">
        <property type="protein sequence ID" value="CCC78709"/>
        <property type="gene ID" value="lp_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1355"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1140"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046138_1_0_9"/>
    <dbReference type="OMA" id="MVELIFA"/>
    <dbReference type="PhylomeDB" id="F9UNC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1167-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="316"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="420" mass="47391" checksum="3015609BBB86B75B" modified="2011-10-19" version="1">MLVFLLQILINRELRQKRVYATVAVMTVLLTVIYMLYDDYSDIITFIVNMGLLAFVRRKKYFIVTSLTATLAYILFSFFGNYATESIFHLFNLGLNDWSGWLFEAIGETIVTACMLAVAASFKVLKKRYPRQFVDGLTLNVIVSALAVVAVAFFTITTAADNYNIGSGFLGILMLILVAILLINAGTFLYLFYSYTLRVQNNRQALERQQYDIYVKNLENSYQNLRKFRHDYQNILLSLGEYIQIADDPELQQYFRQVVTKSKQSLNRDFGHFDNLEQIKDKPLKAIIQSKFSVARQAGIQVRLEANDPIAAIAIDSVTLSRVSGILLDNAIEAVKGQSGGQIAVALVKYPRMVELIFANSLNHPIERLDELMVAGHTSKGAGHGQGLATVRELLDPLANVTYEVSSHQRFEFIISIESE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-01-16" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH3</accession>
    <name>URDA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urocanate reductase</fullName>
            <ecNumber evidence="3 6">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">urdA</name>
        <name evidence="7" type="ordered locus">lp_1425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Cell" volume="175" first="947" last="961">
            <title>Microbially produced imidazole propionate impairs insulin signaling through mTORC1.</title>
            <authorList>
                <person name="Koh A."/>
                <person name="Molinaro A."/>
                <person name="Staahlman M."/>
                <person name="Khan M.T."/>
                <person name="Schmidt C."/>
                <person name="Manneraas-Holm L."/>
                <person name="Wu H."/>
                <person name="Carreras A."/>
                <person name="Jeong H."/>
                <person name="Olofsson L.E."/>
                <person name="Bergh P.O."/>
                <person name="Gerdes V."/>
                <person name="Hartstra A."/>
                <person name="de Brauw M."/>
                <person name="Perkins R."/>
                <person name="Nieuwdorp M."/>
                <person name="Bergstroem G."/>
                <person name="Baeckhed F."/>
            </authorList>
            <dbReference type="PubMed" id="30401435"/>
            <dbReference type="DOI" id="10.1016/j.cell.2018.09.055"/>
        </citation>
        <scope>PREDICTED FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">L.plantarum strain WCFS1 is significantly more abundant in subjects with type 2 diabetes (T2D) compared with subjects with normal glucose tolerance (NGT).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101399.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889276.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UNH3"/>
    <dbReference type="SMR" id="F9UNH3"/>
    <dbReference type="STRING" id="220668.lp_1425"/>
    <dbReference type="DNASU" id="1062454"/>
    <dbReference type="EnsemblBacteria" id="CCC78762">
        <property type="protein sequence ID" value="CCC78762"/>
        <property type="gene ID" value="lp_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1425"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1195"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_0_9"/>
    <dbReference type="OMA" id="RRGHKPM"/>
    <dbReference type="PhylomeDB" id="F9UNH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1223-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000446106" description="Urocanate reductase">
        <location>
            <begin position="1"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="338"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="787"/>
            <end position="788"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0C278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P83223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q8CVD0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="30401435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="30401435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="812" mass="87232" checksum="2154DC2B9F842929" modified="2011-10-19" version="1">MKFVGIVGTNAQHSYNRMLLEFMQRHFATQAEIEILELTDVPMFDESNDQTDSTIIQNFATKIATADGVIIASPEHNHSVPSALKSIIEWLSFKIHPLDGQAVMIVGASYSVQGSSRAQLHLRQILDAPGVNASVMPGSEFLLGRAQTAFDDQGNLKVQGTVDFLDSCFAKFQKFATIVAEMRAPEALSFAPGTYQVTATGHNGELPMRVTLSADRIENIEIDTSSETQGIADVAFERIPKEIIAGQTLAVDAISGASITSHGVIDGVARAVKEAGANPDDLKKRRATKQVAQPAVKEVTTDVVVVGAGGAGMTAAAKVLQAGHQAVVLEKFPAVGGNTVRAGGPMNAADPDWQRQFAALPGEKQTLKDLSERDESTIAPEYRADFRKLKQQIDAYLTANTNQKGTLFDSTLLHRIQTYLGGQRTDLNGQEIHGQYDLVKELTDNALDSVKWLQSIGVKFDESQVTMPVGAIWRRGHKPMGDLGFAYIKTLRAFVEQQGGTIMTETPVKELLVTDGQVRGVIATNAAHEKVIVHADAVILASGGFAANTKMLQKYNTYWTAIDDDVKTTNSPAMTGDGIRLGTSVGAALVGMGFSQMMPVSDPETGELFSGLQVPPANFVMVNQQGKRFVNEYGSRDELTQAAIDNGSLFYLIADDEIKKTAYNTTQAKIDQQVANGTLFRADTLTDLAQQIGMDPAALTKTIADYNRYVDAGEDPEFHKTAFDLKVAVAPFYATPRKPATHHTMGGLKIDSDAHVLNTDGQVIDGLYAAGEVAGGIHAGNRLGGNSLSDIFTFGRIAAAHAVAEHVDPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNL5</accession>
    <name>F9UNL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelatin ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecD</name>
        <name evidence="8" type="ordered locus">lp_1476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889318.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1476"/>
    <dbReference type="EnsemblBacteria" id="CCC78804">
        <property type="protein sequence ID" value="CCC78804"/>
        <property type="gene ID" value="lp_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1476"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1238"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_2_9"/>
    <dbReference type="OMA" id="GINIERE"/>
    <dbReference type="PhylomeDB" id="F9UNL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1265-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="34958" checksum="1E966C594028D78F" modified="2011-10-19" version="1">MIKTRRRGYGILLLTTLALIGLMLVALSLGRYQLSLSELIATLTGQASVSPVIHNIVFSLRLPRILAAAAIGAALAISGTAYQSIFQNPLVSPDLLGVSNGAAVGAALAILLGWHTVGTQILAFALGLIAVLLSVGIPRLIHQSSTLALVLAGIVISGLMQAILGLLKYLADPESQLQDIVYWQLGSLAKVNLNSLGAVWPLLIVGMVILLIMRWRLTVLALGNQVAFAQGINVRLERGLVILSATMLTASAVCLSGTIGWIGLIVPHMARIIIGENTKWSLPLSGLIGAIFLLVVDTLARTLSAGEIPLSILTGFIGTPIFIAILLSKKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS8</accession>
    <name>F9UNS8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal transduction histidine-protein kinase ArlS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hpk5</name>
        <name evidence="13" type="ordered locus">lp_1545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645182.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889381.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1545"/>
    <dbReference type="EnsemblBacteria" id="CCC78867">
        <property type="protein sequence ID" value="CCC78867"/>
        <property type="gene ID" value="lp_1545"/>
    </dbReference>
    <dbReference type="GeneID" id="66449433"/>
    <dbReference type="KEGG" id="lpl:lp_1545"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1301"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="OMA" id="TVIGNFR"/>
    <dbReference type="PhylomeDB" id="F9UNS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1328-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041610">
        <property type="entry name" value="ArlS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18719">
        <property type="entry name" value="ArlS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="284"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="547" mass="62061" checksum="A9119EFC50634E14" modified="2011-10-19" version="1">MTDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVASAVTTVQQSLRTESKGLTIKSVAAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSRTNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGSDAELVGRAPIYAASNHRLIGYTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVNDDPQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHMELLNRWGKDDPQVLSESLAASLSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVTQAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILIILLDNAVKYSTRRKEIHLSLSTDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGHISVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPLDDHEHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY0</accession>
    <name>F9UNY0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recN</name>
        <name evidence="9" type="ordered locus">lp_1605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645158.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889433.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1605"/>
    <dbReference type="EnsemblBacteria" id="CCC78919">
        <property type="protein sequence ID" value="CCC78919"/>
        <property type="gene ID" value="lp_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1605"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1354"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_9"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="PhylomeDB" id="F9UNY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1381-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="564" mass="62826" checksum="01586BAF5BE16F29" modified="2011-10-19" version="1">MLQELSITNFAIIEHLDIAFEAGMTVLTGETGAGKSIIIDAVGLLAGGRGSAEFIRTGADKAVLQGMFILPADGVTAQLLDEAGIEHADNTVILQREITKSGRNTCRINGMLVNTTTLKQIGETIVDIHGQNEHQELMQPEKHLGLLDEFATAKIRKLKQRYQQQYDRYQQLNRELRQKNANEKEWAQRLDMLNFQVDEIAAAQVKVGEEASLTAERDRLDNYQMINQALQQSYTLLAAGEETTGAVDMVGTAMNALEPIANLDPAFNEITVNVKNAFYGLQDAAGQISNQLDLQEFDEGRLDEIEQRLDVLAQLKRKYGDSEQQILDYYQKIAAELAKMTDSEENSEDLAQRVADLKQQLLTTGEALSDKRRAAAKVLQRQIHQELKDLYMDKAIFEVRFKPTKGQIYRSGLDSVEFYIQTNPGERMRPLAKIASGGELSRMMLALKTIFSESQGITSIIFDEVDTGVSGRVAQAIAEKINGIAHFSQVLCITHLPQVAAMSDHHYFIAKKITGKRTKTSVTKLDNAARVQELARMLAGTKVTKLSLEHAEELLRLADEEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY4</accession>
    <name>F9UNY4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine betaine/carnitine/choline ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">opuD</name>
        <name evidence="7" type="ordered locus">lp_1610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640359.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1610"/>
    <dbReference type="EnsemblBacteria" id="CCC78923">
        <property type="protein sequence ID" value="CCC78923"/>
        <property type="gene ID" value="lp_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1610"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1358"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_9"/>
    <dbReference type="OMA" id="TAYVLQG"/>
    <dbReference type="PhylomeDB" id="F9UNY4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1385-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="23039" checksum="352918EB2158B664" modified="2011-10-19" version="1">MAQMNLLQQLIYYYQQNGVYVLSQFSRHFLISIYGVLFAAIVGIPIGIFIAHHSRLSATVIAIANVIQTIPSLAMLSIIMIGLGLGVNTVIVTVFLYALLPIIKNTYTGMQNVSASILDSGKGMGMTRWQLLRMVELPLSLSVIMAGLRNALVLAIGITAIGTFVGAGGLGDIIIRGTNATNGGAIILAGALPTALMAIIADTVLAWIEKRADPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP00</accession>
    <name>F9UP00_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recG</name>
        <name evidence="10" type="ordered locus">lp_1627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645148.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1627"/>
    <dbReference type="EnsemblBacteria" id="CCC78939">
        <property type="protein sequence ID" value="CCC78939"/>
        <property type="gene ID" value="lp_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1627"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1375"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_9"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="PhylomeDB" id="F9UP00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1402-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="269"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="463"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="679" mass="74259" checksum="E525A42C351CFFBB" modified="2011-10-19" version="1">MGQQLSDAVATLSGVGPARQKGLAELGINTIADLLTYYPFRYEDLQVKDVNEIADQEKVTLKGTVASEPVLARFGRKKNRLNFRLLIDHDVYMVTFFNQPYLMKQIETGQDLAVYGKWDATRSSLTGMKIINPNNADSAFGSIYPASKTVKQGTIQKMIKQAYELYAPVITDIVPANLRAKYRLLPRRQMIHDMHFPASQADSTAARRSATYEEFLLFQMQMQVLKQTDATTNGIAIAYDNDRLKAFIKTLPFELTHAQKRVVNEICLDLKSPKHMNRLLQGDVGSGKTIVAAIVMYAAITAGYQAALMAPTEILAEQHANNLAQVFADTDVNVALLTGATKPAARKTLLAALAAGEINLLIGTHALIQDGVTYANLGLVITDEQHRFGVNQRAAFRQKGGQPDALAMTATPIPRTLAITAYGEMDVSEIDELPAGRQPIQTTWVRSNQANSALSFVHQQIDNGSQAYVVTPLIEESETLDVKNAEALSANLQEYFGASVKVGLLHGRMKPEEKDAVMAAFKAGDIQLLVSTTVIEVGVDVKNATIMMIYDADRFGLAQLHQLRGRVGRGTKASYCILVADPKNQQGIERMQIMTQTTNGFVLAQKDLELRGAGDVLGVKQSGMPEFKVGDPIADLTVLQVAQQDAHAIVQQPDWQSQPDNRALAAYLSQKLAAVGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA3</accession>
    <name>F9UPA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101534.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889556.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1749"/>
    <dbReference type="EnsemblBacteria" id="CCC79042">
        <property type="protein sequence ID" value="CCC79042"/>
        <property type="gene ID" value="lp_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1749"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1475"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_4_1_9"/>
    <dbReference type="OMA" id="EWADWAS"/>
    <dbReference type="PhylomeDB" id="F9UPA3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1505-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="36117" checksum="C86C9A68B12CEEDA" modified="2011-10-19" version="1">MSKAAIITLSTLGVLAIGTSLYVNQHQKKTLTANAQTSQQVLTVYAAGPKPLSDQIIHGFEAKTGIKVKSFDGTTGKILSKVKAEQGNPQADVLILASMAAGVDLQKNGQLLTYQPSQAKHLNKQFKDTSHQLINYSASAVGITYNTRHIKSAPTDWSDLTTAPYRNQVTIPDPQTSGSSLDFINAYQMKHGTQLLKALQENGADIGGANKEVLDAVITGQKIAVFGGVDYMSLTAIKKGEKIGFVYPKSGTLVNPRPAMILKASRHQAAAKQFIDYLLSAKVQRQIQKSNLIPGTTSTLTDPRNGEAIKAYTVNWTSANAALTKNVVAFNQVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPC3</accession>
    <name>F9UPC3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889576.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1774"/>
    <dbReference type="ESTHER" id="lacpl-LP.1774">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79062">
        <property type="protein sequence ID" value="CCC79062"/>
        <property type="gene ID" value="lp_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1774"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1496"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052885_0_0_9"/>
    <dbReference type="OMA" id="ASYAFLY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1525-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="29581" checksum="1F032F90898C291D" modified="2011-10-19" version="1">MNQLMTELGQVYYQYRPAGPQQPTLMCLPAFGWDATDYNFKHLMARLPSQVGLLAIDTIGVGRSIHSQMVRTVPHILANLEDVVHHEHVSNLLLVGHSLGASYAFLYAQQHLDNVCGLVLLEPPYAAMAPQLLANVQSFIENYPQLVQQRQTLTLQQLLAEVNPLNLLAERVANARIDLAAYANASILTEAQCLPQLVTTLRTAEKRVLTLPIQVLVTDQRLTAYQQSPWCQLGHLVHAPGQHYLHWTNENFVRQQLLIALSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPD4</accession>
    <name>F9UPD4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101550.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79073">
        <property type="protein sequence ID" value="CCC79073"/>
        <property type="gene ID" value="lp_1786"/>
    </dbReference>
    <dbReference type="GeneID" id="57025400"/>
    <dbReference type="KEGG" id="lpl:lp_1786"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1507"/>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162718_0_0_9"/>
    <dbReference type="OMA" id="IAWNQPM"/>
    <dbReference type="PhylomeDB" id="F9UPD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1536-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="15581" checksum="28B180EAAF7BFE53" modified="2011-10-19" version="1">MEEMPMAEHLDADLAVLTPYLEKLGATPHRAQLITLLNWVHTTFPQLKARVAWNQPMFTDHDTFIIGFSTAKDHLNIALESHTLDSYRNAITAAGDKTTKMLWQVAFDAPINHKLLAEIIQYNMTTKQTMTTFWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI1</accession>
    <name>F9UPI1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xerC</name>
        <name evidence="14" type="ordered locus">lp_1847</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889634.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1847"/>
    <dbReference type="EnsemblBacteria" id="CCC79120">
        <property type="protein sequence ID" value="CCC79120"/>
        <property type="gene ID" value="lp_1847"/>
    </dbReference>
    <dbReference type="GeneID" id="57025432"/>
    <dbReference type="KEGG" id="lpl:lp_1847"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1557"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_9"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="PhylomeDB" id="F9UPI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1583-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011931">
        <property type="entry name" value="Recomb_XerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02224">
        <property type="entry name" value="recomb_XerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="36223" checksum="BC5E5686DDA71160" modified="2011-10-19" version="1">METDYLTLFLKYIRVERQYSEETAAAYREDIQAFNDFLTANGGAKAYTEVDRLDVNVYLSHLYDRHLTRNSIARKVSSLRSFYNFLVKNDLAKLNPFVYVQLKKHAARLPRFFYQKELDVLFQTVYADDSVMGARNAALLEVLYGTGIRLSECVDLQLADVDYDLKMMLIRGKGDKERYVPFGRYAATALQHYETVCRQPVMAKYGQTHQTVFINRHGGPITGGGIEYVLNQIVKKSSLTADIHPHMLRHTFATQMLNNGADLRTVQELLGHTSLSTTQIYAHVTKEHLQQDYRQFFPRATRESTKETEHDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ1</accession>
    <name>F9UPJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase coenzyme, F420-dependent</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101572.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889644.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1859"/>
    <dbReference type="EnsemblBacteria" id="CCC79130">
        <property type="protein sequence ID" value="CCC79130"/>
        <property type="gene ID" value="lp_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1859"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1567"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_0_0_9"/>
    <dbReference type="OMA" id="VPYKAYP"/>
    <dbReference type="PhylomeDB" id="F9UPJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1592-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="232" mass="24902" checksum="BFFFFCCA6B46E2AC" modified="2011-10-19" version="1">MTVKNVGILGAGKVGIVLAELALAAGYDVRISGSGKVSKIELTIQTLVPGAIASENQDVIANSELIILALPLSRYRQIPATALDGKLVIDAMNYWWETDGVREEVLDPQTSSSEQVQQYFKGSHLVKTLNHMGYHNLQEDARPNGDPARKALLVAGDEPQAVATVAHFVETLGFDPIGYPRLADGIMTEPGSPLFGASLSATALQQIIDHFDETDFGRALAAKHVLDVETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN5</accession>
    <name>F9UPN5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="11">PEP synthase</shortName>
            <ecNumber evidence="6 11">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pps</name>
        <name evidence="15" type="ordered locus">lp_1912</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1912"/>
    <dbReference type="EnsemblBacteria" id="CCC79174">
        <property type="protein sequence ID" value="CCC79174"/>
        <property type="gene ID" value="lp_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1912"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1611"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_9"/>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="PhylomeDB" id="F9UPN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1636-MON"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="380"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="488"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="798" mass="88114" checksum="B364FCDD94748DC6" modified="2011-10-19" version="1">MSSRDTANVLWFDELHREDVNLVGGKSSSLGEMTSSMDVPVPYGFATTARAYQYFMTQTGLNDKVNDLLASIQDYENSDELHTACEQIRNLIVNATMPADLAADIEQAYADLAKKMGQTDPFVAIRSSATAEDLPNASFAGQQESYLNIKGAADVVNRVQQCYSSLFTDRATYYRHKQHFPHEKVALSAAIQMMVFSKASGIMFSVNVADGDASKIVIDAIYGLGEYIVLGKVTPDHFVIDKQSMKIVEKNIIKQPVQLMRLPGGGTKEESVPDELQGQPVLTDAQVIELAGYAKEIERHYGCYMDMEYALDTNTNRLWIVQARPETVWSQRNKHKDAADDEDVVDEADAKVIVRGLPASPGLASGVVHVIDNPKDIDQFKQGEVLVTLMTSPDWVPAMKKAAAIVTNNGGMTCHAAIVSREMQIPCIVGTKSKEVAATDVLKTGDVVTVDAKNGVVYQGKVASMLKPKSGATAVAGQVVAAESFAPTATGVMMNLGDPDLADKYSSLPADGIGLMREEFLWTTFIHEHPLYLIEQGHPEKVVNMLADGIAKVVRAMAPRPVVLRFSDFKSSEYRNLKGGDKYEPHEPADLLGWRGASRYYDSKYIEAFKLELAAVKKVRNEFGLKNLNVMIPFVRTVDEAQKVTTIMRDEGLARSADFKVYMMAEIPTNIILADQFNQFVDGYSIGSNDLAMLILGCDRNNDTVAHLFDERNLAVKRAIRHLIKTAHKDGKTVSICGQAPSEYPEFTNFLIQSGIDYVSVNPDMVKETKRNVAHFEQRIMLDKATGRGLQDPIDYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN7</accession>
    <name>F9UPN7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640618.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889690.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1062082"/>
    <dbReference type="EnsemblBacteria" id="CCC79176">
        <property type="protein sequence ID" value="CCC79176"/>
        <property type="gene ID" value="lp_1914"/>
    </dbReference>
    <dbReference type="GeneID" id="57025502"/>
    <dbReference type="KEGG" id="lpl:lp_1914"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1613"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_3_9"/>
    <dbReference type="OMA" id="TEHAETY"/>
    <dbReference type="PhylomeDB" id="F9UPN7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1638-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="177" mass="20030" checksum="B53D46EBC1526E50" modified="2011-10-19" version="1">MPDFSFRDRPDKQRVQLTLGKASSSADAEQVLAFLDFQWTFRTMQATYEQLLDQYQLSESKFIILMLLENETDHTLLPSELATKLGSARATVSKLLVGLQKRGWVEKQHPQDDKRTVAIHLTAAGSSVLTQFLPANFKAVTTIFASFTVQEQQQFKGLLDKIKQGTQQLKSEAINHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ3</accession>
    <name>F9UPQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101599.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1932"/>
    <dbReference type="EnsemblBacteria" id="CCC79192">
        <property type="protein sequence ID" value="CCC79192"/>
        <property type="gene ID" value="lp_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1932"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1629"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_9"/>
    <dbReference type="OMA" id="MLTIGVC"/>
    <dbReference type="PhylomeDB" id="F9UPQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1654-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24559" checksum="F5343EC7A81E11F6" modified="2011-10-19" version="1">MLKMIAFDFDGTLAPTIPMVIDVFRRSVAPYVEHELTKQAIVQTFGLNEVGMVKAVAGQRWPVALAAFYQEYARAHLRVSAPYPGIVTLLELLQQQGVALALITGKAAKSCQISLDVTGLTSYFPTRLYGSECQPNKADNLRQLMRTKSLDAAELFYVGDTRSDFEAADTAGVQCLTAAWDPNQPIVEAGDQIVFTSVEQLWAYLQRRLGHGLVRPMSHKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS8</accession>
    <name>F9UPS8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">dnaG</name>
        <name evidence="17" type="ordered locus">lp_1963</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101607.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889731.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1963"/>
    <dbReference type="EnsemblBacteria" id="CCC79217">
        <property type="protein sequence ID" value="CCC79217"/>
        <property type="gene ID" value="lp_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1963"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1657"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_9"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="PhylomeDB" id="F9UPS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1681-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCC79217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="626" mass="70474" checksum="D3C5D4276337B695" modified="2011-10-19" version="1">MANRIPEEKVEQVRSAVNIADFIGQYVQLKKAGKNLFGLCPFHEERTPSFSVNEQKQIFHCFSCGRGGNVFSFIMDLENLSFPEAVVKVADFGHIDLPASYTAQSQPAAPKDQQQADLLKLYADSAKMYQHILVNTELGEPALKYLHERGLDDETIKTFGIGYAPANQLLLDFFKEHQTDYQLLRQSGLFIENQAGDLRDRFVDRVLFPIKDASGRVIAFSGRILKKSPNEPKYLNSPETKLFNKRSVLFNFDLARGPIRQQKSVVLFEGFMDVIAAYRSGIQNGVASMGTSLTDEQIYMLERVTDTLYVCYDSDMPGQKATDRALKLLGGNSRLNLGVIQMPDGMDPDEYLRAQGQEKFVQVFEDGKQTPTAFEMQYLKHDLNLQNTPDQLTYLQAVLQQLAQLSSSVEQDLYLNQLVAEFDLDKDDLKQQLRSLVGQQAVRRGGGHSDEPQVAPPPAPAPLGPPPATVDGSTNSGPLSRVEKAERLLLYRLLNDHDVWLRVMAIAGFHFVHDSYQQILVYAEAYFKTHNQFDLGNFTDFMTDSDLQPVVTSLEFMDVANESSKEEIADLVNVIMNQQPLVEQINSKKAELTAAKQIGNRDLVQQLTLALIDLYRQQQQVQRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPY1</accession>
    <name>F9UPY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1-6N</name>
        <name evidence="2" type="ordered locus">lp_2022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79270">
        <property type="protein sequence ID" value="CCC79270"/>
        <property type="gene ID" value="lp_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2022"/>
    <dbReference type="HOGENOM" id="CLU_041900_13_0_9"/>
    <dbReference type="PhylomeDB" id="F9UPY1"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="15636" checksum="A31DBDFF6056A22D" modified="2011-10-19" version="1">MSQDHSTKVLLQIKDPNITDLVVQEATNGSLQVLAKLTYPVTVCARCGKRSMVKNGFKTVHIRIPRISERVTILNLKKQRFICKNCGKSSLTTTTLVKKHHQISENSLHAIDLSLTEDRTMASIAAQYNVSTSFVQLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ45</accession>
    <name>F9UQ45_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase, lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101651.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889848.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2098"/>
    <dbReference type="EnsemblBacteria" id="CCC79334">
        <property type="protein sequence ID" value="CCC79334"/>
        <property type="gene ID" value="lp_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2098"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1775"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033792_2_0_9"/>
    <dbReference type="OMA" id="HNPAVNK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1795-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012365">
        <property type="entry name" value="Pesteras_lmo2642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034890">
        <property type="entry name" value="Pesteras_lmo2642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388091" evidence="1">
        <location>
            <begin position="26"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="440" mass="48366" checksum="49338DF82C74F8CE" modified="2011-10-19" version="1">MKLRKSIFGISCVLFGMMLLSGCQKQTKMTLPPVSHKTLTAMVISDDHVIAPSLHDNGKAFTQYAANDAGADLKYSATIFRAFIAKALITKPDVVLISGDITNNGEKASHEYVAKQLRRLTAKHIRVYVVPGNHDLNNPIARRFKGKHQYSTEATSPTQFKKIYHQDGYGQASETDPSSLGYLVKPSKHTWFLMLNSAIYKSNYQQGNSTVGGGLTDGTLQWLTKVGKQAKQAHATLIPVLHHNTMDHTVIHQDYTIGYAEDVRKAFTTAGIKLSLSGHIHAQNIKSTKVKNQSLTDIASGALILGSHYYGTLKINQSNGTATYHATPLNVSAYIKHHRGNKAMRAYQKYDHDVLYAAGYNAALSQLYEDRDETQLSSAKVNQLARGMAAANIALFRGTPVKNSAAIQSWQQMPHNTSLRGFVLATKKLHGNVTWSGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ53</accession>
    <name>F9UQ53_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cps4C</name>
        <name evidence="4" type="ordered locus">lp_2106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889856.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2106"/>
    <dbReference type="EnsemblBacteria" id="CCC79342">
        <property type="protein sequence ID" value="CCC79342"/>
        <property type="gene ID" value="lp_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2106"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1783"/>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQ53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1803-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="264" mass="29255" checksum="45175D5BFDB0B40C" modified="2011-10-19" version="1">MGTAIMGLRPTEYIDLHCHLLPGLDDGPQQLAQAVEMARQAVADGIHYVLATPHHLDRRYQNTGLVVERSVAELQAELKRQQIPLTVFAGQEVHLRDDLATALPHLLGIDVGRRYLLLELPHEQVPNYVAQVIFELLQQGTTPVIAHPERNAQIMAQPERLYDLVQQGCLAQLTAGSLVGQFGRAVKSTALELVECGLVQVIASDAHLMARRGFMMRAGYQALARLDSTNPASFAVNARLLLNGDPVVLGEVLRPNQRRKFWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS7</accession>
    <name>F9UQS7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">lp_2380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2380"/>
    <dbReference type="EnsemblBacteria" id="CCC79566">
        <property type="protein sequence ID" value="CCC79566"/>
        <property type="gene ID" value="lp_2380"/>
    </dbReference>
    <dbReference type="GeneID" id="57025910"/>
    <dbReference type="KEGG" id="lpl:lp_2380"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2012"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041534_0_0_9"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="PhylomeDB" id="F9UQS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2051-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="54"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="320"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="49763" checksum="9D91DF65615C67F9" modified="2011-10-19" version="1">MSINSTLATWTGKSAYWFLHTFRGGGSSLPGKLALKLDPTILKHLAKNYDVIVITGTNGKTLTTALTVKVLREQYPDILTNPSGSNMKQGIVTTFLRAPKAHQKPLAVLEVDEANVIMVTKYITPKAFVFTNIFRDQMDRYGEIYTTYQKILDGVALAPEATIIANGDLPLFNAKQLPNPILYYGFDYQPDHDQQAPANTDGLLCPRCQHILRYHSRTYSNMGKYYCPHCGFERPQLTYKLNALTAMTPTSSDFEINGQAMHLNIGGQYNIYNALAAYAVGRFMDVTPAKIAHALSDNDEQVFGRQETFHVGEKDVTLILVKNPVGLNQVLQTISTDDRPFSFAALLNANYADGIDTSWIWDGNFEKLPALNIPAYISGGERYRDITFRLKVAGVPEDQLTIIPDLTNMTTAIQKLPTKQVYVVATYTAMLQLRKQLASQGIIDGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW3</accession>
    <name>F9UQW3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 34 terminase small subunit TerS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101755.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2423"/>
    <dbReference type="EnsemblBacteria" id="CCC79602">
        <property type="protein sequence ID" value="CCC79602"/>
        <property type="gene ID" value="lp_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2423"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2049"/>
    <dbReference type="eggNOG" id="COG3728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064914_4_0_9"/>
    <dbReference type="OMA" id="ARIMNAS"/>
    <dbReference type="PhylomeDB" id="F9UQW3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2086-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038713">
        <property type="entry name" value="Terminase_Gp1_N_sf"/>
    </dbReference>
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        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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        </source>
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    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="CCC79613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="172" mass="19557" checksum="25FEACAD3853E551" modified="2011-10-19" version="1">MTETQVLVINANLPDIDHPLAIGPEPEMFKLAQHNYKSGEWPFPVRLVKPGTKVRSDAAYLSSMKQDPKQGEREDIKAIRQAHKHGKHTLRELADSTAIELNRVKDLVHKYSLPLSNGYWRAEKHNNPDEVIAYQTLARLCERIDASELSIRKASMSNGKVNGYYISWVPKV</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <source>
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        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA"/>
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    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="57"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="587" mass="64230" checksum="2F7AA94C4DB61FEF" modified="2011-10-19" version="1">METHITSSAKQPHAKYGTRDLLRLIMTHAHPKKGLFVIGILLSFVATICSLGITLMLKEFIDAFNHGTSGQLLLRLGAVIVVQLFASVASSFLLSYTGVDAVSTLRSALWQHIVDLPIPYFDHNRTGELSSRVVNDTSTIFELISSQFSNAINGIISIVGSLTLMLLLNFRLTIIILIVVPLMAVIIVPMGQVLARISKAIQKETANLNSAAVQMIGQNRLVKAMVAEKALKKQGKDQVDRIKGFSVRQIKLISVLNPVLNIMLLAAIFIIIVYGGILVQTNALTIGSLVAFLMYAVQMISPLSSVTGLVTALQQTVGATERIDNILDSPEEDKRLSGETLSTIDTVDFDHVDFGYESDKPVLKDIDLTIHRGERIALIGESGSGKTTLVSLLEAYYTPTRGELDVNGETMASYTIPSIRNQIGYVSQEVDLMPGTIRDNLLLGSTEPVSDEQLSALLTQVGLADWLAELSAGLDTDVGERGLNVSGGQRQRLAIVRALVRHPSLLILDEATASLDNQNQERVTQLLATLPADLTTITIVHRLNQIEAYPRILFMEDGQITGDGNHESLLATHERYRDFYRLQYQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR60</accession>
    <name>F9UR60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2540"/>
    <dbReference type="EnsemblBacteria" id="CCC79699">
        <property type="protein sequence ID" value="CCC79699"/>
        <property type="gene ID" value="lp_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2540"/>
    <dbReference type="HOGENOM" id="CLU_2508597_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="85" mass="10030" checksum="5CAD7271B526C28F" modified="2011-10-19" version="1">MLKPMQTSLNIKVSRHRYKLFARLYPCGRHYNLNGRLCHELFKLVIDFDMLGSSLSLLNEFSIGKVEKSVKDKFHQILKFVVKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR88</accession>
    <name>F9UR88_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hypothetical membrane protein, DUF1211 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">lp_2574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890241.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2574"/>
    <dbReference type="EnsemblBacteria" id="CCC79727">
        <property type="protein sequence ID" value="CCC79727"/>
        <property type="gene ID" value="lp_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2574"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2163"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090238_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9UR88"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2219-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="24001" checksum="6FB4A67B701CC391" modified="2011-10-19" version="1">MKTDRFQAFSDGIFAILITILVLEFHIPDYQPGHLLAALLAQWPLILSYVFSYFYVGTLWLFHHDYFNMLQRIDRNVNMLNLLMLFSITLLDYPMSLVADALTTGNRQDMQTAFIVYDLVALFISATFYFMYAYLHHHQDLKKPGISMAFYAAIKFDPVRSVTIYGLAIVATFWSVWLGAILLAGGIIFHFLAYLRMSRQLEQAKGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR94</accession>
    <name>F9UR94_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="DNASU" id="1062795"/>
    <dbReference type="EnsemblBacteria" id="CCC79733">
        <property type="protein sequence ID" value="CCC79733"/>
        <property type="gene ID" value="lp_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2584"/>
    <dbReference type="HOGENOM" id="CLU_2302330_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="100" mass="11845" checksum="1B60961FBB6C83C8" modified="2011-10-19" version="1">MIRFYMSLSVVKHTILYLCFIFLLLYLKKRYPDNVIIGFFLKIRWCFINSMLHLHFIAIWIAGYRNRCSNSSWNFGYFGCCVETQAKVGRTATNLLLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF9</accession>
    <name>F9URF9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642630.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890312.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2669"/>
    <dbReference type="EnsemblBacteria" id="CCC79798">
        <property type="protein sequence ID" value="CCC79798"/>
        <property type="gene ID" value="lp_2669"/>
    </dbReference>
    <dbReference type="GeneID" id="57026059"/>
    <dbReference type="GeneID" id="66450336"/>
    <dbReference type="KEGG" id="lpl:lp_2669"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2237"/>
    <dbReference type="eggNOG" id="ENOG5030AFM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161305_0_0_9"/>
    <dbReference type="OMA" id="KIVHHEV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2289-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="113" mass="13046" checksum="41073E6DEEDF9773" modified="2011-10-19" version="1">MMPVETKTKIHEDSKKLVYQDSDVKKAMDLIRDRGYVTRADFNQMDDADWAAGFDQKIEAAFLKVEGEDPYIYFEQFDFKGGDIDSIIFDMDQVGTRDHALDLLAEAIHQQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ3</accession>
    <name>F9URJ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ica3</name>
        <name evidence="3" type="ordered locus">lp_2716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642597.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890346.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2716"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79832">
        <property type="protein sequence ID" value="CCC79832"/>
        <property type="gene ID" value="lp_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2716"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2272"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_0_2_9"/>
    <dbReference type="OMA" id="RNRWAEG"/>
    <dbReference type="PhylomeDB" id="F9URJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2323-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="442" mass="51026" checksum="0A325DF0B586FDA8" modified="2011-10-19" version="1">MTNIFIDHIFAATLFKSVINIALLILCLYPIVGSFFWFAGALSYRFIKTNKRDDDWQYIPAEQQPMITIMIPAHNEEVMIEETITYLFTQLNYTNYEVLVMNDGSTDKTATIIQRLQSVYPRLRTVEIEKNKGKAHAFNIGMYFAQGEYILSNDADTIPEKDALMKYMNFFIHDRDMNTSAVTANMDVQNRTSLLGKSQTVEFSSIVGVIKRSQTSINDSMYAYSGANTLYRKQFLIDVGGFRQNRATEDISIAWDHQMVGAVPRFAPNIVFHMNVPTTIRDLYHQRKRWAQGGTEVWLTNIKKFIFHPIVHRYQLSMFVDSTLSIIWSFFFVITSLMFLILMGYFLITGNFERVYHGLMLSFVFVSFELLAGFMQLLAALLLDHHGAKLKYWFFAPLYMLFYWMINPITVVATFIPALKTILGFGSGTWVSPKRQSLQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK8</accession>
    <name>F9URK8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lplA2</name>
        <name evidence="9" type="ordered locus">lp_2734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101898.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2734"/>
    <dbReference type="EnsemblBacteria" id="CCC79847">
        <property type="protein sequence ID" value="CCC79847"/>
        <property type="gene ID" value="lp_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2734"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2287"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_9"/>
    <dbReference type="OMA" id="CYLIPYD"/>
    <dbReference type="PhylomeDB" id="F9URK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2338-MON"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="37193" checksum="C22ED881CD6E584B" modified="2011-10-19" version="1">MRYLASSSHDIRTNLAIETYLMEHADLTEPILYFYINAPCIIVGRYQNVKAEINQDYVDAHHITLTRRTSGGGAVYDDLGNVSFSFITKDDGDGFGNFKRFTAPVLKALHAMGATGATMSGRNDLLIDGKKFSGNAMHVENGRMFSHGTLMYDVDQTQIAKALTVPTDKLASKGIKSVRSRVTNLKPYMAPAYQHLTIEEFRDTLAREILGVADLSQAKTYQLDETALAGVAALNQQYFTNWDWIYGQSPAFTVKQRRHFDAGTVEFQLNVVAGRIEAVTIYGDFFGAEPIAPVVARLTGVKYERQAIMTALAPLDLTRYFGRIAPADLIDLIVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URM4</accession>
    <name>F9URM4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cblA1</name>
        <name evidence="3" type="ordered locus">lp_2751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642565.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890377.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2751"/>
    <dbReference type="EnsemblBacteria" id="CCC79863">
        <property type="protein sequence ID" value="CCC79863"/>
        <property type="gene ID" value="lp_2751"/>
    </dbReference>
    <dbReference type="GeneID" id="57026124"/>
    <dbReference type="KEGG" id="lpl:lp_2751"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2303"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_9"/>
    <dbReference type="OMA" id="WVADTEF"/>
    <dbReference type="PhylomeDB" id="F9URM4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2354-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="50"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="45460" checksum="CD5907B07F8E4605" modified="2011-10-19" version="1">MEQAAFIKKYATTRQHTDSLKWDALQARYGNPDLLAMWVADMEFKVPEQVTQALQERVAHGIYGYSITPDRYYQAFIDWEQARHGLTLKRDWIRFGSGVVNSLYALVNILTQPGDGVLILTPVYYPFFNAVRDNHRQLVTSELRNDRGHYTIDFEDVEQQIKANEVRLFIQCSPHNPVGRIWSEDEETRLLALCEQYHVLVISDEIHQDLEIDRTNHPFKSALTVANGRFSNRVIVVNAPSKTFNLAALLNSHLVIPNPKLRQRYDAQIGRFSQTEISVLGQVAGQTAYESGAAWLDQILAIVRDNYHYLCTTFAAHAPKLVLADLQGTYLTWLDLRAYVQPAATKAFIQDQCQLAVDFGEWFSPDDQGFVRLNLATNPQNVREAAQRIVTCLSQMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URN9</accession>
    <name>F9URN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101909.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890392.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2768"/>
    <dbReference type="EnsemblBacteria" id="CCC79878">
        <property type="protein sequence ID" value="CCC79878"/>
        <property type="gene ID" value="lp_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2768"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2318"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_4_9"/>
    <dbReference type="OMA" id="MGFNITR"/>
    <dbReference type="PhylomeDB" id="F9URN9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2369-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="434" mass="46704" checksum="035FF3CF859C41FE" modified="2011-10-19" version="1">MAIKQPDLTINISNHQSSLQIFKAAASNFISSLSGKMFTFGLGLMLLDETHSAISFGINMIISPIVGLLCLVPIGNLIDTYPHKTVLTGSLTARTLALILFAASINLFTATAKLIPIVLFLIIDAISTNINDTCYSAATHELVNAHNIQRLSSLTQSAISLSSILSPALGVGLYSLVGFSGFVILEIVATLASFGIMLTMKFHYHATNQFANSQHAPVTSHSQFAKFHSGLNYMRSRTMIKITILLSVILNFLYTAVTIGIPYILKDQLHTGNGPIGVLETGSAIGMLLGSLLLTLLPPTGQKRLFLKLIIPVLILDSQILLLGVLFMTSQSPTGYALLGSFIMGILAFALVILNITFQVYLQQTVPTKLLGRVVATLTTVNSSIMPIGTLMFTLIFQSTTHGGLVLIINGILLLGYTLLLLRPLNQAIHSEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ1</accession>
    <name>F9URQ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642540.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890404.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2783"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79890">
        <property type="protein sequence ID" value="CCC79890"/>
        <property type="gene ID" value="lp_2783"/>
    </dbReference>
    <dbReference type="GeneID" id="57026151"/>
    <dbReference type="KEGG" id="lpl:lp_2783"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2330"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_4_9"/>
    <dbReference type="OMA" id="ICADPVF"/>
    <dbReference type="PhylomeDB" id="F9URQ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2381-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="244" mass="27913" checksum="65B932D0BE19E29B" modified="2011-10-19" version="1">MSAPLFSVVVPAYNQHKFIDSCLTSLQRQTLTDFEVFVVDDCSTDDTGEQIAALIKGDDRFHVITHAHNRGVSAARNSGMAAAKGKYLCFVDGDDWVEPDFLATFLAAYRSAPDTQLVVCGHYGYLAVPSPAKTYNQKDLIANINFGTVGGFSWNKAFIRSIITTHHLKFNEDIDFLEDQLFAFRYANYVQSSEYVPDRTYHYRWRFRSNLAHIGIPFFTARRKMMKILKQENKQVLNEDWNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR8</accession>
    <name>F9URR8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5 diketo-D-gluconic acid-like reductase NADP dependent (Promiscuous)</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890421.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2803"/>
    <dbReference type="EnsemblBacteria" id="CCC79907">
        <property type="protein sequence ID" value="CCC79907"/>
        <property type="gene ID" value="lp_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2803"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2347"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="OMA" id="ECGEGVA"/>
    <dbReference type="PhylomeDB" id="F9URR8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2399-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="32311" checksum="7451C26F0FD3E8A4" modified="2011-10-19" version="1">MMVPTTKLNNGVVMPQLGFGVFQVPDLNECEAAVTAALKAGYRLIDTATAYQNETAVGRAIQKSGLRRDELFVTSKLWVSEFTYERAKQGIDASLQRLGVDYLDLYLLHQPYGDVMGAWRALEEAYHAGKIRAIGVSNFYADQLKNLELTMSVQPAVNQIEVNPWYQQADEVRFNQDEHVRVEAWAPFAEGKHAIFSNPSIQTIAQAHGKTTGQVILRWLLQRGITVIPKSVHPERMAENIAVFDFELTAAEMSAMAELDQGVSQFFDHRDPVTIEQIFGASLRQLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9US02</accession>
    <name>F9US02_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF2207 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2914"/>
    <dbReference type="EnsemblBacteria" id="CCC79991">
        <property type="protein sequence ID" value="CCC79991"/>
        <property type="gene ID" value="lp_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2914"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2433"/>
    <dbReference type="eggNOG" id="COG4907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026556_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9US02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2487-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="610" mass="66773" checksum="6312C487C90B148B" modified="2011-10-19" version="1">MSKKRRLSWLSVLGLLAGFCWWFSLAMRAAADYDIDQYQVNVAIQRDGSANVTQAMTYQFDDDYHGVFNVQDLKGIQGAQLEGVTTQLNGGTTVTAAPSETGANNTYQLTQNADRMRVKLYRQVQEDDKLRVVYRYRLKGVVTNYADTAELNWKVIGSGWDVPLNNVKIVIQLPAKNVSALQAWTHGPLSGQTKVERAAGRVTMTLGHNPANQFVESHLLFPTTVTATNTRTNTAKRKATVQKQEAKLAQEANEKRRRNQLLRRVIFGAAVAGWLLVMIGYLWWLARHPAKPHQQPIPINHSFDVPPVTPAVAESLWAQRSPNTDALTAEILRAAANHEITIETVAGHRKPDVRLTQLKPVTNSFLAHCFDKIAVDGQFMLTDLKKYGKRDKAGRLGKWFSRWQTEVDQDVAVYQDETNYRLRNQWLMAAVVVSVMGMIATGAGLLVSPKVVTLMVIPAVVAAVAFWIGWIIQRRRIAINTDAGLELRNQINGLRRMLKDIGHFNTAQVGDLILWEQILPYAAAFGLANQVTKQLAIDFGTEALATGMLVYYPLFYANGGLDFDLSGAINDSFSGALDASGSASSASGGSGGFSGGSSGGFGGGSGGGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9US66</accession>
    <name>F9US66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease HtrA</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">htrA</name>
        <name evidence="9" type="ordered locus">lp_0043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641660.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888127.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0043"/>
    <dbReference type="MEROPS" id="S01.447"/>
    <dbReference type="EnsemblBacteria" id="CCC77613">
        <property type="protein sequence ID" value="CCC77613"/>
        <property type="gene ID" value="lp_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="57026899"/>
    <dbReference type="KEGG" id="lpl:lp_0043"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.35"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_0_2_9"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="PhylomeDB" id="F9US66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-35-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388988" evidence="7">
        <location>
            <begin position="27"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="284"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC77613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="420" mass="43101" checksum="5FDC832644526444" modified="2011-10-19" version="1">MANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKVNVSSQATKVFENNKAAVVSVINLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEYSEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKLSAKIVGTDSVTDLAVLKINSSKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGYATVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIINELVQKGEVVRPALGVATYDLSNISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTKYDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGKLKTANMKLTETTKTLTKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9US68</accession>
    <name>F9US68_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100857.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888129.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77615">
        <property type="protein sequence ID" value="CCC77615"/>
        <property type="gene ID" value="lp_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0046"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.37"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_9"/>
    <dbReference type="OMA" id="NKTIMID"/>
    <dbReference type="PhylomeDB" id="F9US68"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-37-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="191" mass="21873" checksum="470AC054D726ED9B" modified="2011-10-19" version="1">MRERDLAKEKSIIDEVSRIILKEGIADVSMSKIAKASGISSSTIYVYFSDKEDLLKQVYLAKKRQLAAFLSQNINTKPNNSVKFVQQFMYALYDFGMQYYEALMIIEQFNNSPILDSLKIKKEESYQGFEQLFEAVKHTPEFVISSPAVILGFVYAPIVLFVKALKTRQIDNKTIMIDQVVVMCMNALLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9US91</accession>
    <name>F9US91_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-I</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888152.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0073"/>
    <dbReference type="EnsemblBacteria" id="CCC77638">
        <property type="protein sequence ID" value="CCC77638"/>
        <property type="gene ID" value="lp_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0073"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.60"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_3_3_9"/>
    <dbReference type="OMA" id="TSMLHWH"/>
    <dbReference type="PhylomeDB" id="F9US91"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-60-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24969" checksum="9CE8D68BE315D8B7" modified="2011-10-19" version="1">MRINVLQHTPNEGPGMIADWAHAHGHTMYVYHPYQFGVLPTADETEMLVILGGPMSPNDTLPWIKQERDLIQQLLDRDIPMFGACYGAQQIAKTLGYPVTKAPAKEVGWAPIYRQSPVIPGIPAKLSVLHWHEEMFTVPAEATLLFSSDRVTNQGFVWKHRVVGLQFHFEPAADNVREMVVNDYRYIAGSVLNQTAAEILQTPVPRENQQVLNAILNYITAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA2</accession>
    <name>F9USA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2968"/>
    <dbReference type="DNASU" id="1063427"/>
    <dbReference type="EnsemblBacteria" id="CCC80032">
        <property type="protein sequence ID" value="CCC80032"/>
        <property type="gene ID" value="lp_2968"/>
    </dbReference>
    <dbReference type="GeneID" id="57026304"/>
    <dbReference type="KEGG" id="lpl:lp_2968"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2477"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_5_9"/>
    <dbReference type="OMA" id="EQCYIAV"/>
    <dbReference type="PhylomeDB" id="F9USA2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2528-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="24104" checksum="462F15B6826C8141" modified="2011-10-19" version="1">MPTTMTTNIKNNDFKDVVFNRQSVRQFDPTVKIDREELQTIIDETISAPSACNLQSWHFVVADSADGKAKAKSVLMPFNYPQIDSCSAMIFVLGDTQSHLVYRDVWNKACEEGRITPEKRDQIFKTFLPMYENASPEFLQADAMIDSSMAAMQLLLIARAHGYDANPIAGYAADKVATTFGLDAKRYVPVMAIALGKAASEPITTTRYAGTQVTEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA5</accession>
    <name>F9USA5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890549.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2973"/>
    <dbReference type="EnsemblBacteria" id="CCC80035">
        <property type="protein sequence ID" value="CCC80035"/>
        <property type="gene ID" value="lp_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2973"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2480"/>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067296_0_0_9"/>
    <dbReference type="OMA" id="FSANTDW"/>
    <dbReference type="PhylomeDB" id="F9USA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2531-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="333" mass="35695" checksum="5AD71F48DC861925" modified="2011-10-19" version="1">MLITSIGQGLLWAPLVIGVFLTFRILNIPDLTTEGSFPLGAAVTISSMLAGQSAIVASLLGFVAGCLAGWVTGVLDTKLKMPSLLAGILTMTGLYSINMHIMGKANIPLLDQKTLMGWLPASWSLNLQTIVIGSVVTLVVLAGLIWLFQTRLGLSLMATGNNPAMSAANGIYTDRMVIIGYMLSNGLIALSGGLIAQSNGYADIGMGIGTIVIGLASVLVGEIFLHGRQIWVRLTGMVVGAIIYRYLLTLAMGLGFPVNDLKILSAAILVIVICLPLLQNKYRTKRQLRRYLKEIGVDQHATTNYSERPTLAKSLLSRNQQRAARLKGRESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD2</accession>
    <name>F9USD2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890576.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3003"/>
    <dbReference type="DNASU" id="1063501"/>
    <dbReference type="EnsemblBacteria" id="CCC80062">
        <property type="protein sequence ID" value="CCC80062"/>
        <property type="gene ID" value="lp_3003"/>
    </dbReference>
    <dbReference type="GeneID" id="57026332"/>
    <dbReference type="GeneID" id="66450599"/>
    <dbReference type="KEGG" id="lpl:lp_3003"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2507"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_2_9"/>
    <dbReference type="OMA" id="WRFVHAS"/>
    <dbReference type="PhylomeDB" id="F9USD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2556-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="31220" checksum="89B1F970B668627C" modified="2011-10-19" version="1">MQHRIAVLADIHGNLTALNAVLADARQQAATDYWFLGDLFLPGPGAEKLYQTLADTAPSVWLQGNWEQGINAVMTGNGRLDDPSQIYFARLTAYLVTHLSKSHYAELVQRPIATTMVVNGLTFQLAHNQPERSTGHDLYPDERQSNFDHLAGDADVAVYGHTHQQIMRVSQRGQLIINPGATGQPYSPYAKFMADQRAHYAILTVDDAGRISVDFRKVDYDISLELTVAREQQLPYLDLYEHLRRTGFTSTHDQALLGKLNAKFNYANEVRRFFGMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9USH5</accession>
    <name>F9USH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">copA</name>
        <name evidence="7" type="ordered locus">lp_3055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890619.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3055"/>
    <dbReference type="EnsemblBacteria" id="CCC80105">
        <property type="protein sequence ID" value="CCC80105"/>
        <property type="gene ID" value="lp_3055"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3055"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2552"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_9"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="PhylomeDB" id="F9USH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2598-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="641" mass="67806" checksum="8A2BEEC0CD9FB1C6" modified="2011-10-19" version="1">MNTTKRFWISLIFSLPLLANMILMPFGWMLPGGDWTQLILTTIIMAVSARPFLQSAWASFTKHHVNMDTLVAIGTATAYFYSLYAMATGQAVFFESAALVTTFVLLGQVFEERMRHNASSAVAKLVGLQAKEAEVLRDQEFVKVPLDQVVVGDIIRVKPGEKIPVDGVITTGRSTVDESMVTGESMPVQKTVADAVIGSTINSNGTFQFKASKVGDQTMLAQIVELVKKAQNSHAPIQKLTDKVSDIFVPIVLIIAIVTFLTWYVFLNASLANALIFAVAVVVIACPCALGLATPTALMVGTGRGAKMGILIKNGEVLEAVNDVKTVIFDKTGTITVGHPQVTDVIGDEAQVLRVATSLEAASEHPLAAAILKRGTARGIQAPTATNFQAIEGKGVTAQVEGQLAVVGNHKLLTDEPISAELQRQATELQDAAKTVVYVGLNHEIIGLIAIQDVAKSTSEVAIASLKARGLKTVMLTGDNERVAQAVADQVGIDEVIADVLPGDKAEHVHAFQKAGKVAFVGDGINDAPALTTADVGIAMGSGTDIAIDAGGIVLVKNDLRDVDRALALSKKTFNRIKLNLFWAFVYNVLGIPVAAGLFFAIGLTLSPELAGLAMAFSSLSVVTSSVLLNKAKISSNAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USJ4</accession>
    <name>F9USJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(Pyro)phosphohydrolase, HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102032.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890638.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3078"/>
    <dbReference type="EnsemblBacteria" id="CCC80124">
        <property type="protein sequence ID" value="CCC80124"/>
        <property type="gene ID" value="lp_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3078"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2571"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_2_9"/>
    <dbReference type="OMA" id="DSERVYT"/>
    <dbReference type="PhylomeDB" id="F9USJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2617-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="217" mass="24140" checksum="D9EE3638702EDE37" modified="2011-10-19" version="1">MTKAVIFDLDGLLIDSEVISLKMYQRIVQDYGQTLSMATYAQEYSGKSAVTNMQHLIERFDLPFDVDTGLKRALALEKTFMQDGVELKPGARVLLQFLHRNHYSVALASSSIKSRALDILTSHDVAQYFDQFTFGPDVDRGKPYPDIFLMACAKLQQQPADCLVLEDSEAGIQAATSAKIPVICVPDMKRPNQPYADQATAIVPSLTDVITYLKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ6</accession>
    <name>F9USQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall hydrolase/muramidase, N-terminal</fullName>
            <ecNumber evidence="3">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acm3-N</name>
        <name evidence="3" type="ordered locus">lp_3151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102059.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3151"/>
    <dbReference type="EnsemblBacteria" id="CCC80186">
        <property type="protein sequence ID" value="CCC80186"/>
        <property type="gene ID" value="lp_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3151"/>
    <dbReference type="HOGENOM" id="CLU_1037431_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394418" evidence="2">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="268" mass="27962" checksum="9F78CCF7A6C81544" modified="2011-10-19" version="1">MKKWSTYNKNTSHKIVELSSIVVMSSVLGIILAKPVQGKADQTSSPSTTKVKAATSGATSEVSSISTITANSATNVSSATHQFSTATTTSQQASSATSNISTTTASKQISKSTTGKLNSNETATTSNSAATSVASTAPYIPAKSNVSFTDNIKSTIANTPTTVAAPAIPSHSTQFIDDSAPITSPTPVTTNSIHVRPFTVHSSFSFKPGQFLRFTLPNVALLRDDVEQGVPNYVKNFFIAIKPGAMIGWSQYHILPSISGAQALLESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV0</accession>
    <name>F9USV0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100897.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888195.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0128"/>
    <dbReference type="DNASU" id="1061341"/>
    <dbReference type="EnsemblBacteria" id="CCC77681">
        <property type="protein sequence ID" value="CCC77681"/>
        <property type="gene ID" value="lp_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0128"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.105"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675661_0_0_9"/>
    <dbReference type="OMA" id="FEREWFI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-103-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17632" checksum="7A9C72472A6E43CD" modified="2011-10-19" version="1">MTTPLVSQLMTELNQFLTQDSVDDQEKRWAMQQTTDPQLQAALKQLSTTDIKIMAYLGRRGASRAKSLPAPTELSQATISRGLTKLSRLKLATKYRDLTNNKEILVRLTTLGEAVADLHTQLDATIAAKAQAIADDYSDAELRRFVSLMRRIREIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY6</accession>
    <name>F9USY6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltase/sucrase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malA1</name>
        <name evidence="2" type="ordered locus">lp_0174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641769.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0174"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77717">
        <property type="protein sequence ID" value="CCC77717"/>
        <property type="gene ID" value="lp_0174"/>
    </dbReference>
    <dbReference type="GeneID" id="57027004"/>
    <dbReference type="KEGG" id="lpl:lp_0174"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.142"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_9"/>
    <dbReference type="OMA" id="DYYIFAG"/>
    <dbReference type="PhylomeDB" id="F9USY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-139-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="13"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="557" mass="62931" checksum="5F5A19BD0653DFBA" modified="2011-10-19" version="1">MSKHWYDQQTIYQIYPKSFNDSNHDGIGDIPGITAKIPYLKQLGITTIWLNPIYQSPQVDNGYDVSDYYQVDSSLGTMTDVETLIKTVHEHGMYLIFDFVLNHTSDQHPWFKQALADPQSKYRDYYLWQDPAADGGRPNNWGSFFGGSVWAKDPAGGSQYYFHLFDKRMPDLNWKNPAVQQAMRDVAEFWVEKGIDGLRLDAFIHLAKADFRQTYPNRTGDSTPIISDMFYAHLPKVHQYLHDFVAVIKAKHPDTYVVGEASSADPHLMVDYTTPGTDECDQVITFRTFADDNTQDDPSFSDTFQPRPMDVTAYKQNTVGIQAALADTSLPTLYWNNHDMARVATRYGDPDYPQASAKALATALYLQRGIPIIYYGEELGLTNIRYHDIADFEDQTVPTFVASAQAAGKSKVEIMRMLNQTHKMAGRGPMQWDNTVYHGFSDHLPWKHGDTDDMNAQAEIADPDSIYHYYQQLLQLKQCAPFTNGQFIMLGSAEQLFTYLIDDGQKQAAIVCNLSAQAQTYLLPFVGGKVLLVQGGATYRGRQVTLPAWSSLVVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT37</accession>
    <name>F9UT37_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA1</name>
        <name evidence="7" type="ordered locus">lp_0236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641827.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0236"/>
    <dbReference type="EnsemblBacteria" id="CCC77768">
        <property type="protein sequence ID" value="CCC77768"/>
        <property type="gene ID" value="lp_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="57027058"/>
    <dbReference type="KEGG" id="lpl:lp_0236"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.196"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_9"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="PhylomeDB" id="F9UT37"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-190-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="110" mass="12207" checksum="87B38417CDCF501A" modified="2011-10-19" version="1">MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQHQEIAQQFEIMSIPALVIFKNGQPAEKVVGFHPQAALKKYLDQKLAEVKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT56</accession>
    <name>F9UT56_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnuC1</name>
        <name evidence="7" type="ordered locus">lp_0259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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        <property type="gene ID" value="lp_0259"/>
    </dbReference>
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    <dbReference type="KEGG" id="lpl:lp_0259"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.214"/>
    <dbReference type="eggNOG" id="COG3201">
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    <dbReference type="OMA" id="SSWFHHK"/>
    <dbReference type="PhylomeDB" id="F9UT56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-209-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641840.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888302.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0260"/>
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    <dbReference type="EnsemblBacteria" id="CCC77788">
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    </dbReference>
    <dbReference type="GeneID" id="57027078"/>
    <dbReference type="KEGG" id="lpl:lp_0260"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCC77788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="92" mass="10848" checksum="4F0C9B92D1F87824" modified="2011-10-19" version="1">MDWFVNLEREDQEFVKQLVIASGSLKQLAKIYQVSYPTVRMRLNTIIQKINFIEDNGANTFETKVMKLVIDEKLSLEVAKQIITDFREEQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTC8</accession>
    <name>F9UTC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, ATP-binding protein</fullName>
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    <gene>
        <name evidence="7" type="ordered locus">lp_3225</name>
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    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890760.1">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
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        <property type="entry name" value="AAA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="216" mass="24031" checksum="EFA9E02E0031790A" modified="2011-10-19" version="1">MNSLISLEKVNYQIADQHILHDVDWQIPAGAHITLTGPSGGGKSTLLRIIAAMISKTSGTLIFDGQPIESYDPIMYRRQVSYCFQQPTLFGETVADNLAFPYQIRKQVMDTQRVVTALNNVGLSERTLHQPITELSGGERQRVALIRNILFLPKVLLLDEVTAGLDENNKQIVHAWLRQLNEQDHVTTIMITHDATEIAAADQLAKVVAGRLEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888359.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_0321"/>
    <dbReference type="EnsemblBacteria" id="CCC77845">
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        <property type="gene ID" value="lp_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0321"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.273"/>
    <dbReference type="eggNOG" id="COG0456">
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    <dbReference type="OMA" id="IHLMCKE"/>
    <dbReference type="PhylomeDB" id="F9UTS5"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="161"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="17724" checksum="959CB797BB52407F" modified="2011-10-19" version="1">MEITPVKMLDLPQIMAIEKSGFSEAEAGSEAAYRERIEKLADTFLVARDGAVVLGFIVGPAVGARYIEDEMFVETPTNLPRGGHQLVFTLAVSPLARHQQIGSQLLTALAEKAQADGRTSMALTCLKRLIPFYERNGFINQGVANSEHAGETWYNLEKVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS6</accession>
    <name>F9UTS6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC77846">
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        <property type="gene ID" value="lp_0322"/>
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    <dbReference type="KEGG" id="lpl:lp_0322"/>
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    <dbReference type="eggNOG" id="COG0456">
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    <dbReference type="HOGENOM" id="CLU_099453_1_0_9"/>
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    <dbReference type="PhylomeDB" id="F9UTS6"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_10"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC77846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="175" mass="19738" checksum="8F17D1C3ABBEBC65" modified="2011-10-19" version="1">MKLATLQAQLPDFEIRLLTLADQEALLKLEQSNPRYHQYFSPEPLTMTEVQHDLTAHPDELAAAQKQVFGFYLAHRLVAVLDVLNQYPQEQFLFVGLLMVNKAYQRKSVGRVIVTGLMQAALQANITAIQLTRVTADEGVARFWQKLGFEDGNQLFLPLKAGGRLAVTTMTRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT8</accession>
    <name>F9UTT8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643749.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0336"/>
    <dbReference type="EnsemblBacteria" id="CCC77858">
        <property type="protein sequence ID" value="CCC77858"/>
        <property type="gene ID" value="lp_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="57027149"/>
    <dbReference type="KEGG" id="lpl:lp_0336"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.286"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_0_1_9"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="PhylomeDB" id="F9UTT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-280-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:biotin transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="BioY"/>
    </dbReference>
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        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="187" mass="19752" checksum="27369C182F5B2D46" modified="2011-10-19" version="1">MTNRQTIKHLTQTAMVTALIIVLGFFPGIPVGFIPVPIVLQNMGIFLAAELLGRKYGTIAVGLFLGLVALGLPLLSGGRGGAAIFLGPTGGYLVAWLLAPMLIGTLIKITRAMTSGYWWLEVGIVWLAGILFVDVIGASWLAVQSHMTLTAALLSNVAFLPGDIIKGTLAVFIARRVRAIVDFGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTV5</accession>
    <name>F9UTV5_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Phospholipid-binding protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888389.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0358"/>
    <dbReference type="EnsemblBacteria" id="CCC77875">
        <property type="protein sequence ID" value="CCC77875"/>
        <property type="gene ID" value="lp_0358"/>
    </dbReference>
    <dbReference type="GeneID" id="57027166"/>
    <dbReference type="KEGG" id="lpl:lp_0358"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.302"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_4_2_9"/>
    <dbReference type="OMA" id="DHHYLIQ"/>
    <dbReference type="PhylomeDB" id="F9UTV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-297-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="18205" checksum="D931215D8CA22463" modified="2011-10-19" version="1">MQLSIPTINGALAATYSKQAAVAQTYKGHPIISFPVDISDVPAGTHSLAFTFVDHDAIPVGGFTWIHWIAANLPATTTHIPENASQTGAIPMVQGNNSTAGAYVHETDPKVSQHYVGPYPPDKDHRYSFKLFALDTELDLQPGYWLNEFHDAIAGHVLATAKTTVIGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU23</accession>
    <name>F9UU23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642000.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888457.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0438"/>
    <dbReference type="DNASU" id="1064162"/>
    <dbReference type="EnsemblBacteria" id="CCC77943">
        <property type="protein sequence ID" value="CCC77943"/>
        <property type="gene ID" value="lp_0438"/>
    </dbReference>
    <dbReference type="GeneID" id="57024238"/>
    <dbReference type="GeneID" id="66448518"/>
    <dbReference type="KEGG" id="lpl:lp_0438"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.358"/>
    <dbReference type="eggNOG" id="ENOG50337UX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135501_1_1_9"/>
    <dbReference type="OMA" id="FIQMIND"/>
    <dbReference type="PhylomeDB" id="F9UU23"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-364-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021701">
        <property type="entry name" value="DUF3284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11687">
        <property type="entry name" value="DUF3284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="16182" checksum="EEE579B8F66828AC" modified="2011-10-19" version="1">MQIKLTLNAPVDYLYQQLIDSARADIQQQTGRPAPRQSLQGYEYAKQWSNGLTGNLKITHAQPGVRYAYELETPRDHYGVDYQFAPDTDGHQTVLEYAETFLGKDKKTNANNKLGVLFLGWFRKRRFKKMMNQMAASYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU31</accession>
    <name>F9UU31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppx1</name>
        <name evidence="2" type="ordered locus">lp_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888465.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0446"/>
    <dbReference type="EnsemblBacteria" id="CCC77951">
        <property type="protein sequence ID" value="CCC77951"/>
        <property type="gene ID" value="lp_0446"/>
    </dbReference>
    <dbReference type="GeneID" id="66448524"/>
    <dbReference type="KEGG" id="lpl:lp_0446"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.366"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_0_9"/>
    <dbReference type="OMA" id="YVPKIGL"/>
    <dbReference type="PhylomeDB" id="F9UU31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-372-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="34173" checksum="B5E42E05C5B2CB45" modified="2011-10-19" version="1">MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKALLNFRRLYEKMPNTDVIGITTAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLGVANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGAVTLSEQFGLDDLVPSASLFRAQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVFHTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIISEHLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU57</accession>
    <name>F9UU57_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80359">
        <property type="protein sequence ID" value="CCC80359"/>
        <property type="gene ID" value="lp_3373"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3373"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2812"/>
    <dbReference type="eggNOG" id="COG5562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1967734_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2847-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009833">
        <property type="entry name" value="DUF1398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036696">
        <property type="entry name" value="YdfO-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07166">
        <property type="entry name" value="DUF1398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160419">
        <property type="entry name" value="SSF160419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="13841" checksum="66912EDDB64A08CF" modified="2011-10-19" version="1">MFKLTEIDDVLNNLGDHADFATIAKKEADLGVQHFQYDVATGATTYFGENGYLVERRTNGLAVRVAREEDAAAVEQIAKQYIAGQLALADAVKQFAKAGCQAWTANLKRHIVDFSGDEGKIMAAVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB9</accession>
    <name>F9UUB9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, Crp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3444"/>
    <dbReference type="DNASU" id="1063595"/>
    <dbReference type="EnsemblBacteria" id="CCC80421">
        <property type="protein sequence ID" value="CCC80421"/>
        <property type="gene ID" value="lp_3444"/>
    </dbReference>
    <dbReference type="GeneID" id="57026667"/>
    <dbReference type="KEGG" id="lpl:lp_3444"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2869"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_0_9"/>
    <dbReference type="OMA" id="AEVCVMP"/>
    <dbReference type="PhylomeDB" id="F9UUB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2909-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="24528" checksum="A1C377A26183900B" modified="2011-10-19" version="1">MAEHECVQLVPIFSELGSEQLDTIESIVRHHHYPAGSTLFGADDPLDSLMIVANGQVKVYQLAANGREQLLYLLQTGDIDGEAALFENQRRTSFGEALVPTDVCSIRRSDFQDLMQKYPSISINVLNVFGKRLSQLERQTTSTATESVEARLANYITETAAALKTDTFKLPLKKKDLATFLGTTPESISRKLALFERQGLITQKPGKVIEINDADQLLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK6</accession>
    <name>F9UUK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase, possibly 2-phosphoglycolate phosphohydrolase or inorganic pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph3</name>
        <name evidence="1" type="ordered locus">lp_3544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUK6"/>
    <dbReference type="STRING" id="220668.lp_3544"/>
    <dbReference type="DNASU" id="1061939"/>
    <dbReference type="EnsemblBacteria" id="CCC80508">
        <property type="protein sequence ID" value="CCC80508"/>
        <property type="gene ID" value="lp_3544"/>
    </dbReference>
    <dbReference type="GeneID" id="57026744"/>
    <dbReference type="KEGG" id="lpl:lp_3544"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2955"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_9"/>
    <dbReference type="OMA" id="KWIRNMA"/>
    <dbReference type="PhylomeDB" id="F9UUK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2996-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23467" checksum="AA32A400BFDBC732" modified="2011-10-19" version="1">MKYQNILFDIDNTLINSADLIAKLLKEGAVREGVDMPIEEYRKRIGQPGEMILREFGVQNWQNVLARYLIEFNENMNELTYFVGVEQMLDDLLAMNLTVGVVTSKDRVQFDKEVSHFPIIAKMPIVTTADLTKNPKPSGEPITYTLERFNLARERTLYVGDSIFDMQASKNAGVDFVVAKWGALPNVDFNNAKYQAKTPNDIVGIVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>P77889</accession>
    <accession>F9URH9</accession>
    <name>PYRE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="1">OPRT</shortName>
            <shortName evidence="1">OPRTase</shortName>
            <ecNumber evidence="1">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrE</name>
        <name type="ordered locus">lp_2697</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A60993">
        <property type="entry name" value="A60993"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101885.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890332.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77889"/>
    <dbReference type="SMR" id="P77889"/>
    <dbReference type="STRING" id="220668.lp_2697"/>
    <dbReference type="PRIDE" id="P77889"/>
    <dbReference type="EnsemblBacteria" id="CCC79818">
        <property type="protein sequence ID" value="CCC79818"/>
        <property type="gene ID" value="lp_2697"/>
    </dbReference>
    <dbReference type="GeneID" id="66450355"/>
    <dbReference type="KEGG" id="lpl:lp_2697"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2257"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_1_1_9"/>
    <dbReference type="OMA" id="ENPFTWA"/>
    <dbReference type="PhylomeDB" id="P77889"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2309-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110705" description="Orotate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="123"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <sequence length="212" mass="22705" checksum="9289C7D8A0516985" modified="1997-02-01" version="1">MSEIAATIATDLLTIKAVTLRPNDPFTWASGIKSPIYTDNRLTISYPAVRQHIAHGIAAIIKREYPATEVIAGVATAGIPHAAWVAELLNLPLIYVRAKPKDHGAGRQIEGVLKPGQKVVMLDDLISTGGSVLQAAKAVQAAGGDIQAVGAIFSYALDAATQNFAAASLPLFSLSNYPELIKVARQADYIDDEELASLHTWRQDPEHWGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG8</accession>
    <name>Q6LWG8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003678463.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133723.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723559"/>
    <dbReference type="EnsemblBacteria" id="CAG17840">
        <property type="protein sequence ID" value="CAG17840"/>
        <property type="gene ID" value="CAG17840"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17840"/>
    <dbReference type="HOGENOM" id="CLU_2479459_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3140-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="87" mass="10115" checksum="6DD9A7A981061D28" modified="2004-07-05" version="1">MIQTELATFGFGLINNRKPILFSRKYSTSRYFLLISVAKMNDYDRFRGDFRELSCKLRNCISSTQLASITARNIVFCKHRRASISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH4</accession>
    <name>Q6LWH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222014.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133717.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17834">
        <property type="protein sequence ID" value="CAG17834"/>
        <property type="gene ID" value="CAG17834"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17834"/>
    <dbReference type="HOGENOM" id="CLU_2396014_0_0_9"/>
    <dbReference type="OMA" id="IRYTRVN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3134-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="110" mass="12974" checksum="FB4732F103A21C1E" modified="2004-07-05" version="1">MENRKPSSQIPKKKRKLVELLECKDYIVPLNPDVIVKKTIYRSSARITERQRNQVKRVLRSQGYQGRISSIRYTRVNYKYSFKVSVKYQGNVGKFLVNTKNETVEFKGMV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U30</accession>
    <accession>F9URJ5</accession>
    <name>PUR2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purD</name>
        <name type="ordered locus">lp_2719</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101891.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890348.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U30"/>
    <dbReference type="SMR" id="Q88U30"/>
    <dbReference type="STRING" id="220668.lp_2719"/>
    <dbReference type="EnsemblBacteria" id="CCC79834">
        <property type="protein sequence ID" value="CCC79834"/>
        <property type="gene ID" value="lp_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2719"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2274"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_9"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="PhylomeDB" id="Q88U30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2325-MON"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151456" description="Phosphoribosylamine--glycine ligase">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="109"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <sequence length="413" mass="43463" checksum="10AE0CDB704F08FF" modified="2003-06-01" version="1">MANVLVVGGGGREHAIAKAMMASPQVSTVYCAPGNPGMIRDGIRTLAIDEMDFAGLVNFARANTVTLTFVGPEVPLAAGIVDYFQAAGLAIFGPNQAAAQLESSKVFAKAFMSRHHIPTADYRQFHELDSALAYSHEQAVPQVIKVDGLAAGKGVTVATSHEQAAAAIKTAFKTSSTVLIEDYVAGFEFSQMVLVGGEHYALLPTAQDHKRLQDHDRGPNTGGMGAYSPVPQITPAVIDQTIATIIEPTIAGLKADGLSFEGVIYVGGILTATGVQVIEYNLRLGDPETQILLPQLQSDFYQVIVDLLQHRQPHAQWQTTATYLGVVLAAPGYPGPTEAGVPVPTVAGADYASVAGTPDQLVSAGGRVMMVTASAPSLVAAQRAVYQQIDQLRVGDLVYRTDIGAKGMTATHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88U67</accession>
    <accession>F9URE9</accession>
    <name>PHK1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoketolase 1</fullName>
            <ecNumber evidence="1">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2659</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101870.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890302.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88U67"/>
    <dbReference type="SMR" id="Q88U67"/>
    <dbReference type="STRING" id="220668.lp_2659"/>
    <dbReference type="PRIDE" id="Q88U67"/>
    <dbReference type="EnsemblBacteria" id="CCC79788">
        <property type="protein sequence ID" value="CCC79788"/>
        <property type="gene ID" value="lp_2659"/>
    </dbReference>
    <dbReference type="GeneID" id="57026049"/>
    <dbReference type="KEGG" id="lpl:lp_2659"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2227"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_9"/>
    <dbReference type="OMA" id="LSTMDHC"/>
    <dbReference type="PhylomeDB" id="Q88U67"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2279-MON"/>
    <dbReference type="BRENDA" id="4.1.2.9">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="chain" id="PRO_0000193878" description="Probable phosphoketolase 1">
        <location>
            <begin position="1"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <sequence length="788" mass="88731" checksum="215485F754AA48E9" modified="2003-06-01" version="1">MTTDYSSPAYLQKVDKYWRAANYLSVGQLYLKDNPLLQRPLKASDVKVHPIGHWGTIAGQNFIYAHLNRVINKYGLKMFYVEGPGHGGQVMVSNSYLDGTYTDIYPEITQDVEGMQKLFKQFSFPGGVASHAAPETPGSIHEGGELGYSISHGVGAILDNPDEIAAVVVGDGESETGPLATSWQSTKFINPINDGAVLPILNLNGFKISNPTIFGRTSDAKIKEYFESMNWEPIFVEGDDPEKVHPALAKAMDEAVEKIKAIQKHARENNDATLPVWPMIVFRAPKGWTGPKSWDGDKIEGSFRAHQIPIPVDQNDMEHADALVDWLESYQPKELFNEDGSLKDDIKEIIPTGDSRMAANPITNGGVDPKALNLPNFRDYAVDTSKEGANVKQDMIVWSDYLRDVIKKNPDNFRLFGPDETMSNRLYGVFETTNRQWMEDIHPDSDQYEAPAGRVLDAQLSEHQAEGWLEGYVLTGRHGLFASYEAFLRVVDSMLTQHFKWLRKANELDWRKKYPSLNIIAASTVFQQDHNGYTHQDPGALTHLAEKKPEYIREYLPADANTLLAVGDVIFRSQEKINYVVTSKHPRQQWFSIEEAKQLVDNGLGIIDWASTDQGSEPDIVFAAAGTEPTLETLAAIQLLHDSFPEMKIRFVNVVDILKLRSPEKDPRGLSDAEFDHYFTKDKPVVFAFHGYEDLVRDIFFDRHNHNLYVHGYRENGDITTPFDVRVMNQMDRFDLAKSAIAAQPAMENTGAAFVQSMDNMLAKHNAYIRDAGTDLPEVNDWQWKGLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UD9</accession>
    <accession>F9UR76</accession>
    <name>HIS1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="1">ATP-PRT</shortName>
            <shortName evidence="1">ATP-PRTase</shortName>
            <ecNumber evidence="1">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisG</name>
        <name type="ordered locus">lp_2560</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642712.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890229.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UD9"/>
    <dbReference type="SMR" id="Q88UD9"/>
    <dbReference type="STRING" id="220668.lp_2560"/>
    <dbReference type="EnsemblBacteria" id="CCC79715">
        <property type="protein sequence ID" value="CCC79715"/>
        <property type="gene ID" value="lp_2560"/>
    </dbReference>
    <dbReference type="GeneID" id="57025979"/>
    <dbReference type="KEGG" id="lpl:lp_2560"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2151"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_9"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="PhylomeDB" id="Q88UD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2207-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000151912" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <sequence length="218" mass="24385" checksum="5E7D6DE2ACA24FAF" modified="2003-06-01" version="1">MTEPRLKIALTKGRVEQQVLPLLEEAGLDCSQVRNKQRRLIFDSETQPYEFILAKGPDVTTFLERGAADIGIVGSDILTEHESTQYELLDLGVGKCQFVLASTADFDPVAPRRKIIGTKYPLITQRYFDRLGQDVEIIKIEGSVELAPLTGLADAIVDITETGTTIRENHLQIYDYLQPVSTRLVVNRLALKQQQAAIFDLVDRLATVVDTNNPKEFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V07</accession>
    <accession>F9UQJ9</accession>
    <name>DPO4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinB</name>
        <name type="synonym">dinP</name>
        <name type="ordered locus">lp_2280</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641518.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V07"/>
    <dbReference type="SMR" id="Q88V07"/>
    <dbReference type="STRING" id="220668.lp_2280"/>
    <dbReference type="EnsemblBacteria" id="CCC79488">
        <property type="protein sequence ID" value="CCC79488"/>
        <property type="gene ID" value="lp_2280"/>
    </dbReference>
    <dbReference type="GeneID" id="57025824"/>
    <dbReference type="KEGG" id="lpl:lp_2280"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1930"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_9"/>
    <dbReference type="PhylomeDB" id="Q88V07"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1972-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0515">Mutator protein</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173918" description="DNA polymerase IV">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <sequence length="377" mass="42788" checksum="2C38B86B85AE6A14" modified="2011-11-16" version="2">MAQSIVEAPIRVDTSRKIIHVDMDAFYASIEEREHPAYKTQPLVIAHDPRQTGGRGVVTTANYVARQFGVHSAMPAAKALELCPTAVFKTPNFPLYREVSAQIHRIFHEYTEMIEPIAFDEAYLDVTTNKKHIHSAVELAHRLQQEIWHQTHLTCSTGISYNKFIAKLASDYRKPAGVTIVLPQDAEPFLLREPIEKFRGVGKKTVPKMHDLGIKTGQDLYAQSELDLIKQFGKLGYILYRRVRGSDDRPVEYLRERKSIGKERTFGPFLQSTTEVNTHLKAIAKLVAASMQSHQRHGKTLVLKLRYGDFVTITKRRTFGEFIPNDAALFEQYAEEIFEEVVDDHFNSGIRLLGITLTGLAPLAFENLTLPLYPNDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-07" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V20</accession>
    <accession>F9UQI6</accession>
    <name>IXTPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2267</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889989.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V20"/>
    <dbReference type="SMR" id="Q88V20"/>
    <dbReference type="STRING" id="220668.lp_2267"/>
    <dbReference type="EnsemblBacteria" id="CCC79475">
        <property type="protein sequence ID" value="CCC79475"/>
        <property type="gene ID" value="lp_2267"/>
    </dbReference>
    <dbReference type="GeneID" id="57025812"/>
    <dbReference type="KEGG" id="lpl:lp_2267"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1918"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_9"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="PhylomeDB" id="Q88V20"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1960-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178180" description="dITP/XTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <sequence length="202" mass="21791" checksum="C0A70C9BA2043C64" modified="2003-06-01" version="1">MTKPQTLIIATNNANKAREFSAMLAPYDITIKTLADFPNIPEIKENGITFEENATKKATVVVEATGLPAIADDSGLMVKALHGDPGVFSARYAGDHDDAANNAKLLANLGGVPEAERTATFHTTLVALKPSGEKLVVNGELAGRILIAPRGDNGFGYDPLFWSSKFQKSLAELTPAQKNQISHRGAALRQLMTKFDEWWAKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-27" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VH3</accession>
    <accession>F9UQ32</accession>
    <name>Y2083_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein lp_2083</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2083</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889835.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VH3"/>
    <dbReference type="SMR" id="Q88VH3"/>
    <dbReference type="STRING" id="220668.lp_2083"/>
    <dbReference type="EnsemblBacteria" id="CCC79321">
        <property type="protein sequence ID" value="CCC79321"/>
        <property type="gene ID" value="lp_2083"/>
    </dbReference>
    <dbReference type="GeneID" id="57025628"/>
    <dbReference type="GeneID" id="66449855"/>
    <dbReference type="KEGG" id="lpl:lp_2083"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1762"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_1_9"/>
    <dbReference type="OMA" id="ETRNQAM"/>
    <dbReference type="PhylomeDB" id="Q88VH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1782-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138471" description="UPF0145 protein lp_2083">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <sequence length="115" mass="12401" checksum="1E1F1AEA1F9B70B1" modified="2003-06-01" version="1">MTQLLVTTTENIPGHPYEVIGEVFGLTTQSKNLVRNIGAGLKGLVGGEIKDYTKMLEESRDVAVNRLRDNASAMGADAVVMMRFDTGSISQDMQSVAAYGTAVRFITEDLTTDNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VQ7</accession>
    <accession>F9UPU5</accession>
    <name>SYH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">lp_1981</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640691.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889748.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VQ7"/>
    <dbReference type="SMR" id="Q88VQ7"/>
    <dbReference type="STRING" id="220668.lp_1981"/>
    <dbReference type="EnsemblBacteria" id="CCC79234">
        <property type="protein sequence ID" value="CCC79234"/>
        <property type="gene ID" value="lp_1981"/>
    </dbReference>
    <dbReference type="GeneID" id="57025559"/>
    <dbReference type="KEGG" id="lpl:lp_1981"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1674"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_9"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="PhylomeDB" id="Q88VQ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1698-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136179" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="426" mass="47904" checksum="50989A27F811D5EC" modified="2003-06-16" version="1">MRYQRPKGTADILPGDSEKWQYVEATARAVFKTYQFKEIRTPMFENFEVFSRSAGDTSDIVTKEMYDFHDKGDRHITLRPEGTAGVVRAFVENKLYGPQVLKPYKVYYMGPMFRYERPQSGRLREFHQLGVEAFGSESAALDVEVIAMGYNLLKTFGLTDLKLVINTLGDQQTRDDYRQALIDYLEPHFDELSDDSKERLHKNPLRVLDSKAPEDQQFVADAPSILDYLSPEAQAHFDQTKTYLDALAIPYEIDATMVRGLDYYNHTIFEIMTHSKALGKGYTTICAGGRYNGLVKELGGPEVSGVGFGLGVERLLVLMDAENIAVPTDDQLDVYVVGIGDTASATTLKLVQALRAAGYKAERDYLDRKPKAQFKSADRLNARYTMTVGETELADQVVNLKAMATGEETKVAMADIYQDAHQVLDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VR2</accession>
    <accession>F9UPU0</accession>
    <name>END4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable endonuclease 4</fullName>
            <ecNumber evidence="1">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfo</name>
        <name type="ordered locus">lp_1976</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VR2"/>
    <dbReference type="SMR" id="Q88VR2"/>
    <dbReference type="STRING" id="220668.lp_1976"/>
    <dbReference type="EnsemblBacteria" id="CCC79229">
        <property type="protein sequence ID" value="CCC79229"/>
        <property type="gene ID" value="lp_1976"/>
    </dbReference>
    <dbReference type="GeneID" id="57025554"/>
    <dbReference type="KEGG" id="lpl:lp_1976"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1669"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_4_1_9"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="PhylomeDB" id="Q88VR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1693-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000190845" description="Probable endonuclease 4">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <sequence length="298" mass="33009" checksum="C4CC316674355CFF" modified="2003-06-01" version="1">MLRLGSHVSMKAPDMLLGSANEAASYGANTFMIYTGAPQNTRRKPIDELKIDEAQPIIEAHDLRQIVVHAPYIINLGNTKKPGYFEFATDFLYQEIQRADAVGATQLTLHPGAHIGAGANVAITQIIKGLNAVIRPEQHVQIALETMAGKGTEVGRTFEELAQMIDGVTYNEKLSVTFDTCHTSDAGYAIKDDFDGVLNEFDHVIGLDRLKVIHLNDSKNPQGAHKDRHTNIGMGTIGFDTLNKVAHHPQLPDISKILETPYVGEDKKHQLPPYKYEIAMLRAGQFNPHLIEDIEQQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W32</accession>
    <accession>F9UPH3</accession>
    <name>PPAC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable manganese-dependent inorganic pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="1">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppaC</name>
        <name type="ordered locus">lp_1837</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPase class C family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640554.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889626.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W32"/>
    <dbReference type="SMR" id="Q88W32"/>
    <dbReference type="STRING" id="220668.lp_1837"/>
    <dbReference type="PRIDE" id="Q88W32"/>
    <dbReference type="EnsemblBacteria" id="CCC79112">
        <property type="protein sequence ID" value="CCC79112"/>
        <property type="gene ID" value="lp_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1837"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1549"/>
    <dbReference type="eggNOG" id="COG1227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025243_0_1_9"/>
    <dbReference type="OMA" id="IMLCAIL"/>
    <dbReference type="PhylomeDB" id="Q88W32"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1575-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00207">
        <property type="entry name" value="PPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022934">
        <property type="entry name" value="Mn-dep_inorganic_PyrPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158574" description="Probable manganese-dependent inorganic pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00207"/>
        </source>
    </evidence>
    <sequence length="309" mass="33620" checksum="A83E215146B8A2C9" modified="2003-06-01" version="1">MSKELVFGHQNPDTDAIVAAKAFSYYENKMGADTEAVALGEPNEETQFVLDYFDEPALRVITKASDEVDSVMLVDHNEPQQSVSDIADVTVSHVVDHHRIAGFDTAQPLFYRAEPLGCCSTVIYKLFKENDIEIPAKLAGLMLSAIISDTLLLKSPTTTETDVAVVKDLAKIADIDYETYGLAMLKAGTNLDSKTEKELIDADAKSFEMAGKTVRVAQINTVDLDDVFKRQAALEAAAKDENASDGYDLFLILATNILDSNSELLVVGNPTEPVEKAFGKTIANNRLSLPGVVSRKKQVVPQLTDAFNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W76</accession>
    <accession>F9UPC7</accession>
    <name>FTHS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="1">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="1">FHS</shortName>
            <shortName evidence="1">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fhs</name>
        <name type="ordered locus">lp_1779</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W76"/>
    <dbReference type="SMR" id="Q88W76"/>
    <dbReference type="STRING" id="220668.lp_1779"/>
    <dbReference type="EnsemblBacteria" id="CCC79066">
        <property type="protein sequence ID" value="CCC79066"/>
        <property type="gene ID" value="lp_1779"/>
    </dbReference>
    <dbReference type="GeneID" id="57025392"/>
    <dbReference type="KEGG" id="lpl:lp_1779"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1500"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_9"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="PhylomeDB" id="Q88W76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1529-MON"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000199354" description="Formate--tetrahydrofolate ligase">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <sequence length="551" mass="57936" checksum="6FA655CDF7526F7B" modified="2003-06-01" version="1">MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINPTPAGEGKSTVTIGLGDALTKIGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINLHFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWKRALDINDRALRHTVIGLGGATSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAITLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGADLGGQKFMDINVPAVGQAPNAVVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHIHAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAVLADVWGRGGDGATDLAAAVVDLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVCMAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMDISDDGKISGLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WF3</accession>
    <accession>F9UP50</accession>
    <name>RSGA2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit biogenesis GTPase RsgA 2</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsgA2</name>
        <name type="ordered locus">lp_1687</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101507.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889503.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WF3"/>
    <dbReference type="SMR" id="Q88WF3"/>
    <dbReference type="STRING" id="220668.lp_1687"/>
    <dbReference type="EnsemblBacteria" id="CCC78989">
        <property type="protein sequence ID" value="CCC78989"/>
        <property type="gene ID" value="lp_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1687"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1425"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_9"/>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="PhylomeDB" id="Q88WF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1452-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000171484" description="Small ribosomal subunit biogenesis GTPase RsgA 2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <sequence length="352" mass="38312" checksum="BEFB36901E8D9E4E" modified="2003-06-01" version="1">MTINLIKYGLTTAVQADLTKENGQILGRIIGQHRDWYQVITTAGERSAQVTGKLAYEAASPAAFPAVGDWVCLSSSADNQAQIEAIAPRQSVLARGAVNRQDGQIIATNINTIFICMSLNADFNVRRLERYLTIAWDSGALPVIVLTKADLCTDLATKLRAVADVSVGVPTITCSVETGQGLDELQPYLTTGQTVAFVGSSGVGKSTLINRLLGQDILATKSIRTDDNKGRHTTTSRQLIPLPTGACVIDTPGMRELQIFMGDLNQTFAEIAALATQCKFNDCTHTSEPGCAVRAAVEVGTVTSERLQSYQKLQREMSYQGLNSRQLEQAKIQRMFGGKQAMKRVKQRYHRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WI1</accession>
    <accession>F9UP22</accession>
    <name>TRPF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="1">PRAI</shortName>
            <ecNumber evidence="1">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpF</name>
        <name type="ordered locus">lp_1656</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101491.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889475.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WI1"/>
    <dbReference type="SMR" id="Q88WI1"/>
    <dbReference type="STRING" id="220668.lp_1656"/>
    <dbReference type="EnsemblBacteria" id="CCC78961">
        <property type="protein sequence ID" value="CCC78961"/>
        <property type="gene ID" value="lp_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1656"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1397"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_0_9"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="PhylomeDB" id="Q88WI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1424-MON"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154360" description="N-(5'-phosphoribosyl)anthranilate isomerase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <sequence length="208" mass="22828" checksum="420252A909403ABF" modified="2003-06-01" version="1">MTQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVFTTNQLSEILALVQQHIIQVVQLHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLLDNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAINKVYPAMVDVASGVETAGNKDREKINLMVQRAHQTGVSTPLLTEIRRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WN1</accession>
    <accession>F9UNX1</accession>
    <name>EFP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">lp_1596</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640346.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WN1"/>
    <dbReference type="SMR" id="Q88WN1"/>
    <dbReference type="STRING" id="220668.lp_1596"/>
    <dbReference type="EnsemblBacteria" id="CCC78910">
        <property type="protein sequence ID" value="CCC78910"/>
        <property type="gene ID" value="lp_1596"/>
    </dbReference>
    <dbReference type="GeneID" id="57025180"/>
    <dbReference type="GeneID" id="66449480"/>
    <dbReference type="KEGG" id="lpl:lp_1596"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1345"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_9"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="PhylomeDB" id="Q88WN1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1372-MON"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094268" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="185" mass="20366" checksum="AE46616DF52F334B" modified="2003-06-06" version="1">MISTADFKNGLTIEVDNAIWRIVEFQHVKPGKGGAFVRSKLKNLRTGAVQDKTFRAGARMEQAPIEKSTMQYLYADGDSYVFMNTETYEQIEIPGDHIQDELKFLKENMEVQVTLYKGEVLGIDLPNTVTLEVAETEPGIKGDTASGGSKPATLETGAIIQVPFFVKAGDKLIVNTVDSTYVSRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WN3</accession>
    <accession>F9UNW9</accession>
    <name>RL27_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">lp_1594</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638594.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WN3"/>
    <dbReference type="SMR" id="Q88WN3"/>
    <dbReference type="STRING" id="220668.lp_1594"/>
    <dbReference type="EnsemblBacteria" id="CCC78908">
        <property type="protein sequence ID" value="CCC78908"/>
        <property type="gene ID" value="lp_1594"/>
    </dbReference>
    <dbReference type="GeneID" id="49393863"/>
    <dbReference type="GeneID" id="57025178"/>
    <dbReference type="GeneID" id="66449478"/>
    <dbReference type="KEGG" id="lpl:lp_1594"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1343"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_9"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="PhylomeDB" id="Q88WN3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1370-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000181105" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="92" mass="10077" checksum="25953B57D3063782" modified="2003-06-01" version="1">MLMNLQFFSHHKGGGSTANGRDSAGRRLGAKRADGQTVKNGNILYRQRGTHIYPGVNVGRGGDDTLFAMADGVVRFERKGRDKRQVSVYPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WP5</accession>
    <accession>F9UNV7</accession>
    <name>MIAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">lp_1579</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889410.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WP5"/>
    <dbReference type="SMR" id="Q88WP5"/>
    <dbReference type="STRING" id="220668.lp_1579"/>
    <dbReference type="EnsemblBacteria" id="CCC78896">
        <property type="protein sequence ID" value="CCC78896"/>
        <property type="gene ID" value="lp_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1579"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1330"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_9"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="PhylomeDB" id="Q88WP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1357-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000163930" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="311" mass="34730" checksum="F853EB0F8F5022FD" modified="2003-06-01" version="1">MTTVTKHKVLLIAGPTAVGKTALSLALAKQLNGEIISGDSMQVYRHLDIGTAKIMPEEQAGIPHHLIDIKNIDQRFTVAEFVSRTTALIIDISARGKLPIIVGGTGFYLQSLLAGYQFGPADNEPDMAYRQAWFDRAAVEGSDVAWMALKQRDPQAATAIAPANLVRVVRALEYVHTTGQLFSEQADTHGDTLDAYTLCLTAERALLYTRINQRVDQMVAAGLEQEARWLFDQGGAMLPAGKGIGYHEWFPYFNGEQTRDESIAKIKQDSRRYAKRQLTWFRNKMSVDWINLLEHPELRASIDQRLASWLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X40</accession>
    <accession>F9UNF8</accession>
    <name>DLTC2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-alanyl carrier protein 2</fullName>
            <shortName evidence="1">DCP 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-alanine--poly(phosphoribitol) ligase subunit 2-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dltC2</name>
        <name type="ordered locus">lp_1406</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; lipoteichoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DltC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889261.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X40"/>
    <dbReference type="SMR" id="Q88X40"/>
    <dbReference type="STRING" id="220668.lp_1406"/>
    <dbReference type="EnsemblBacteria" id="CCC78747">
        <property type="protein sequence ID" value="CCC78747"/>
        <property type="gene ID" value="lp_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="57025039"/>
    <dbReference type="GeneID" id="66449248"/>
    <dbReference type="KEGG" id="lpl:lp_1406"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1179"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_19_0_9"/>
    <dbReference type="OMA" id="DREQWNT"/>
    <dbReference type="PhylomeDB" id="Q88X40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1208-MON"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036370">
        <property type="term" value="F:D-alanyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070395">
        <property type="term" value="P:lipoteichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00565">
        <property type="entry name" value="DltC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003230">
        <property type="entry name" value="DltC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01688">
        <property type="entry name" value="dltC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213092" description="D-alanyl carrier protein 2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00565"/>
        </source>
    </evidence>
    <sequence length="80" mass="8794" checksum="E30FD31B449D8C73" modified="2003-06-01" version="1">MIMDDVKATVLSILQDLTGEDVSNNMDANLFDEGILDSMGSVQLLLELQNQLGIEVPVSEFERSEWETPAKIVAKVASLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XP6</accession>
    <accession>F9UMV0</accession>
    <name>GATB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">lp_1149</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641343.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889053.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XP6"/>
    <dbReference type="SMR" id="Q88XP6"/>
    <dbReference type="STRING" id="220668.lp_1149"/>
    <dbReference type="DNASU" id="1063228"/>
    <dbReference type="EnsemblBacteria" id="CCC78539">
        <property type="protein sequence ID" value="CCC78539"/>
        <property type="gene ID" value="lp_1149"/>
    </dbReference>
    <dbReference type="GeneID" id="57024785"/>
    <dbReference type="KEGG" id="lpl:lp_1149"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.970"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_9"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="PhylomeDB" id="Q88XP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-981-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148798" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <sequence length="474" mass="53193" checksum="42B338045E662265" modified="2003-06-01" version="1">MNFVTTIGLEVHVELKTNSKIFSPSPVQFGSEPNANTNVIDWGYPGVLPTPNKGVVEAGIKAATALHAEIEHHTYFDRKNYFYPDNPKAYQITQHEKPIAHDGWIEIEVDGKKKKIGIEEMHIEEDAGKNTHENDYSYVDLNRQGTPLIEIVSKPDIASPEEAYAYCEALRQRIQFTGVSDVKMEEGSMRVDVNISIRPAGSDKYGVKTEMKNLNSFNYVRKSLEYEEQRQQQVLMAGGKIQQETRRFDETTGQTILMRVKEGSDDYRYFPEPDIPAVDIDDDWIASVKKTIPEMPGSRRERYINEFGLTAYDAGVLTQTKEMSDFFDATVAEGADPKLASNYLQGDVNAYLNEHKVDLLATDLTPTNLAGMIKMISDETISSKIAKKVFKAIMAGSEPVQWVNDKGLVQLSDPAKLQPIVDDVLDNNQQSIDDFKNGKDRAVGFLVGQIMKKTRGQANPKVVNQLLMTSLKAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YE7</accession>
    <accession>F9UM40</accession>
    <name>GLMS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="1">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name type="synonym">glmS1</name>
        <name type="ordered locus">lp_0822</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641075.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888793.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YE7"/>
    <dbReference type="SMR" id="Q88YE7"/>
    <dbReference type="STRING" id="220668.lp_0822"/>
    <dbReference type="EnsemblBacteria" id="CCC78279">
        <property type="protein sequence ID" value="CCC78279"/>
        <property type="gene ID" value="lp_0822"/>
    </dbReference>
    <dbReference type="GeneID" id="57024520"/>
    <dbReference type="KEGG" id="lpl:lp_0822"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.697"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_1_9"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="PhylomeDB" id="Q88YE7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-715-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000135344" description="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]">
        <location>
            <begin position="2"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 1" evidence="1">
        <location>
            <begin position="286"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 2" evidence="1">
        <location>
            <begin position="458"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="1">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <sequence length="605" mass="65467" checksum="E66D35D8127D7822" modified="2007-01-23" version="2">MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVGEAVHGSTGIGHTRWATHGEPSVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFKSQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYGFLLMDKEDPDTLYVAKNKSPLLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVDIDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVAAGTSYHAGLVGAKLFESLANVPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVLLNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVASTKAYTAQIALQAILAKALGVAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVSLETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAARGAKTVTIVTDSLAKDGDTVILPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YZ4</accession>
    <accession>F9UL58</accession>
    <accession>Q9LCH0</accession>
    <name>FABH1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1</fullName>
            <ecNumber evidence="1">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase III protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketoacyl-ACP synthase III 1</fullName>
            <shortName evidence="1">KAS III 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabH1</name>
        <name type="ordered locus">lp_0588</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Appl. Environ. Microbiol." volume="67" first="426" last="433">
            <title>Molecular characterization of Lactobacillus plantarum genes for beta-ketoacyl-acyl carrier protein synthase III(fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesis.</title>
            <authorList>
                <person name="Kiatpapan P."/>
                <person name="Kobayashi H."/>
                <person name="Sakaguchi M."/>
                <person name="Ono H."/>
                <person name="Yamashita M."/>
                <person name="Kaneko Y."/>
                <person name="Murooka Y."/>
            </authorList>
            <dbReference type="PubMed" id="11133475"/>
            <dbReference type="DOI" id="10.1128/AEM.67.1.426-433.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>L137</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="1"/>
    <dbReference type="EMBL" id="AB025973">
        <property type="protein sequence ID" value="BAA93641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888587.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YZ4"/>
    <dbReference type="SMR" id="Q88YZ4"/>
    <dbReference type="STRING" id="220668.lp_0588"/>
    <dbReference type="EnsemblBacteria" id="CCC78073">
        <property type="protein sequence ID" value="CCC78073"/>
        <property type="gene ID" value="lp_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0588"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.492"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_9"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="PhylomeDB" id="Q88YZ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-504-MON"/>
    <dbReference type="BRENDA" id="2.3.1.180">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110437" description="3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="1">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA93641." evidence="2" ref="1">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="323" mass="34391" checksum="83C4C6B3DA71427D" modified="2003-06-01" version="1">MPTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQVAQQLLQKSGLAASAIDLILVTTITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFGLATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFGDGAGGALLQATDNPDENSLIAEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIASAQLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDTLTGPVLLTAFGGGLAYGSVLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKV9</accession>
    <name>F9UKV9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101018.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888488.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0476"/>
    <dbReference type="EnsemblBacteria" id="CCC77974">
        <property type="protein sequence ID" value="CCC77974"/>
        <property type="gene ID" value="lp_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0476"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.391"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_0_0_9"/>
    <dbReference type="OMA" id="FSHAMEH"/>
    <dbReference type="PhylomeDB" id="F9UKV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-395-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="450" mass="52273" checksum="5F8E9C3CE73BAD6A" modified="2011-10-19" version="1">MAYRQQLLPMEKVFRDPVHDYIYIQHQVILDLINTSEFQRLRRIKQLGTTSLTFHGAEHSRFGHCLGVYEITRRICDNFERNYPTQAPGDGGWDDHERLVALCAALLHDIGHGPYSHTFEHIFHTDHEALTVQILTSPETEVNQVLQQVSPDFPAQVAAVIQKTYPNPQVVQMISSQIDADRMDYLLRDSYFTGTNYGNFDLTRILRVMKPYQGGITFAMEGMHAVEDYIVSRFQMYMQVYFHPVSRSMEVILDRLLERANDLYQSHAVDAEATPVMLLPFFNNNFTLHDYLRLDDGVLNTYFSHWRDSRDQILADLATRFLDRRPLKSARVAATTQPLIPTLQKLIEQAGFDTHYYTDINDSYDLPYDAYDPKMKKPRTQIELQQKDGSLLELSTVSDLVRAITGKVSGDQRFFFPKEMLSKNAENDLFKPIYQEFQQYILNDRLVVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX2</accession>
    <name>F9UKX2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0490"/>
    <dbReference type="EnsemblBacteria" id="CCC77987">
        <property type="protein sequence ID" value="CCC77987"/>
        <property type="gene ID" value="lp_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0490"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.404"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_7_1_9"/>
    <dbReference type="PhylomeDB" id="F9UKX2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-408-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19748" checksum="020C307C215BB095" modified="2011-10-19" version="1">MARLVLDELDYQEINLSSVKIFDVKDFRFSPSWPRQNDEYYGIIEQLKRAKIIVFSTPIYWYGTSAVLKRFIERWSESIKVDTDFRESMQEKKIVLIIVGGDNPVVKGQIIIDQFKYICEFLGMKLIVSVIGEANRPDTISNDPNALYEAKKANIILKKLDMGGNDFANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKZ5</accession>
    <name>F9UKZ5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="7 8">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murF</name>
        <name evidence="12" type="ordered locus">lp_0518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:16085"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:70758"/>
            <dbReference type="ChEBI" id="CHEBI:83903"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="7 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643844.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888524.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0518"/>
    <dbReference type="EnsemblBacteria" id="CCC78010">
        <property type="protein sequence ID" value="CCC78010"/>
        <property type="gene ID" value="lp_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0518"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.427"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_9"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="PhylomeDB" id="F9UKZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-431-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="110"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="318"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="462" mass="50182" checksum="75D84E44ADD6D309" modified="2011-10-19" version="1">MKMQVAEIAKAVQAVNAEQAWPDVNVTGVAFDSRKLQAGDLFIPLMGANDGHQYIQSAIEHGAVATLWASDHADDVPEDLPVIMVADTLTALQQLGQYYLQKINPKVVAVTGSNGKTTTKDMIASVLSTQFNVTKTHANFNNQIGVPVTLLSMEPNTEVVVVEMGMDHFGELDFLSRLVQPDVAVITMIGEAHIEFFGTRDRIADAKMEIVHGLKEDGTFIFNGDEPLLQERAKEVSQHQRTFGLDDTNTLAGSDITTSRAQTQFKTSLWPDNTYTIPMMGAYNVNNALAALLVADTFHIRPAAAQQAIASFVPTENRTEWLTGYRGEAILSDVYNSNPTAARRVLAAFAAVPTKGQRIAVLGDMLELGDQSDALHMSLASELDPATIASVYLNGEHMRALAEVLQEKYPAGAVHYYQTDQQPQLIADLTATVSADDQVLLKGSHGIHLEKVLTALEAAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL42</accession>
    <name>F9UL42_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 11">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hom2</name>
        <name evidence="15" type="ordered locus">lp_0571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888571.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UL42"/>
    <dbReference type="STRING" id="220668.lp_0571"/>
    <dbReference type="EnsemblBacteria" id="CCC78057">
        <property type="protein sequence ID" value="CCC78057"/>
        <property type="gene ID" value="lp_0571"/>
    </dbReference>
    <dbReference type="GeneID" id="57024352"/>
    <dbReference type="GeneID" id="66448624"/>
    <dbReference type="KEGG" id="lpl:lp_0571"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.475"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_9"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="PhylomeDB" id="F9UL42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-487-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="14">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="13">
        <location>
            <begin position="137"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC78057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="428" mass="46672" checksum="415C493A9992BD54" modified="2011-10-19" version="1">METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQMTDQIATLLDDPSIQIMVEVMGSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIARENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNGTTNYIMTQMLTKHWSYDQALSSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAHQLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPGAGELPTANSVLSDITTVAKNIALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPGMMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMNDQQLADITREIGEQENMQLLASYKVLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL64</accession>
    <name>F9UL64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mleP1</name>
        <name evidence="8" type="ordered locus">lp_0594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888593.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1061554"/>
    <dbReference type="EnsemblBacteria" id="CCC78079">
        <property type="protein sequence ID" value="CCC78079"/>
        <property type="gene ID" value="lp_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="57024374"/>
    <dbReference type="GeneID" id="66448641"/>
    <dbReference type="KEGG" id="lpl:lp_0594"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.498"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_2_9"/>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="PhylomeDB" id="F9UL64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-510-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="35275" checksum="EA765117D8486611" modified="2011-10-19" version="1">MQILQTFVQSIQGVMTIIVMIAVGYLLARWGWFNESATKLIARLVTQIALPAYMIATITKQFTAHKLLSTLPGLRFPVLNMAILFGISFGVMRALNIKKSHRGLFASMFLNSNTVFIGLPVNQALFGNSALPYVLVYYMANTTIFWTLGVYLIQRDGTGTAKFDLKQTLTKIFSPPLLGFMIGVLLVLGNIHVPKFLMDDFSYIGGLTIPLSMIFIGISMANAGLSSMRFDRDSLGILLGRFILAPVLMTLMLIPMSIPLEMKQVFILQSAMPVMTNAPVVSKLYGADADYAAVMVTETTLLSLIVIPILMVIVQANFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL82</accession>
    <name>F9UL82_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">lp_0617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888611.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0617"/>
    <dbReference type="EnsemblBacteria" id="CCC78097">
        <property type="protein sequence ID" value="CCC78097"/>
        <property type="gene ID" value="lp_0617"/>
    </dbReference>
    <dbReference type="GeneID" id="57024392"/>
    <dbReference type="GeneID" id="66448659"/>
    <dbReference type="KEGG" id="lpl:lp_0617"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.517"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_9"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="PhylomeDB" id="F9UL82"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-528-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="182" mass="20593" checksum="DC3AEAEC465AF5CC" modified="2011-10-19" version="1">MVESVEKRWYVLHTYAGYENKVSSNLESRIQSMGMEDNIFRVVVPEEEAHEVKNGKDKVEMKKIFPGYVLVEMVMTDQAWYIVRNTPGVTGFLGSHGQGSKPTPLLPEEAEQILHQLGMSARHTELDVEVGEQVTIIDGAFSGLSGEITEIDNEKMKLKVNINMFGRETSTELDFDQVDQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULC8</accession>
    <name>F9ULC8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine dimer DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891049.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3573"/>
    <dbReference type="EnsemblBacteria" id="CCC80535">
        <property type="protein sequence ID" value="CCC80535"/>
        <property type="gene ID" value="lp_3573"/>
    </dbReference>
    <dbReference type="GeneID" id="57026769"/>
    <dbReference type="GeneID" id="66451009"/>
    <dbReference type="KEGG" id="lpl:lp_3573"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2981"/>
    <dbReference type="eggNOG" id="ENOG5031ARI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131456_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9ULC8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3023-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012650">
        <property type="entry name" value="CHP02328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02328">
        <property type="entry name" value="TIGR02328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="123" mass="14506" checksum="C15195BA92820523" modified="2011-10-19" version="1">MRLWHEQLIHQLPRQQLLGQHRELAALRGNGWGKNHATVNYVFKYSPYKLYQFHVLVMDEMQLRGYHPNKIWYDPNYRGQFCPPYDHLTPIALTTPIYPEHNASYLAECVRNLAAKGIIMPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH9</accession>
    <name>F9ULH9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional protien: transcription regulator sugar kinase, ROK family</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102267.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3630"/>
    <dbReference type="EnsemblBacteria" id="CCC80586">
        <property type="protein sequence ID" value="CCC80586"/>
        <property type="gene ID" value="lp_3630"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3630"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3030"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_9"/>
    <dbReference type="OMA" id="DANCAGM"/>
    <dbReference type="PhylomeDB" id="F9ULH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3073-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="30994" checksum="BE7CCF335267BB22" modified="2011-10-19" version="1">MAPLGLIDIGGTTIKFAVWQDSTLTRHHAVTTPTTKAAFMDLLQREVEQMKAQAAIVGVGISSPGAVNQATGVIEGASAIPYIHNFPIQAELTARFKLPVSIENDANCAALAEASTGVGQGATSLAFLVIGTGVGGALIFNQQIWHGAHLFGGEFGYTKINTTGTLSELGTVPNAIHRYQQAMNQTGKMTGQQLYQLADTGDGVARHEIDTMYAALAQGIFNIQYSFDPEKIILGGGVSNNSDLIPGIQRALTAIYQQVKIATLKPTLVTCQYTDEANLRGAAVDFEQSQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULM1</accession>
    <name>F9ULM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3678"/>
    <dbReference type="EnsemblBacteria" id="CCC80628">
        <property type="protein sequence ID" value="CCC80628"/>
        <property type="gene ID" value="lp_3678"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3678"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3072"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_1_0_9"/>
    <dbReference type="OMA" id="EETHYRY"/>
    <dbReference type="PhylomeDB" id="F9ULM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3115-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394248" evidence="2">
        <location>
            <begin position="31"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="175"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="39628" checksum="1763AF39DC5EBD26" modified="2011-10-19" version="1">MRLKVVIQFIRLMGVSLGFSILIGQTGVSANRQQSVHNNNVGFSVAAEIPKNQIHKQNSFFDLKMASGQQQTLRTVIYNVTNKDIKVRTAIHTAYTNTNGTIEYINPAKSYDQSLKYRVSDLATIQGERTITIPAEGSKTVAIKVKLPKQPVNGVLLGGWYFKRVDDKVTGVTEKSINVKNEYSYVIGLKLSSGKLPISNLCLGPVKAGLNNYHRSIIVALRNPVARIIPNLKIRTVIINKRHQKVIIKNTKTGVMMAPNTVFKAPMPLGSQQLQPGDYQLQMTVNNQRHHWRFKRDFHISMTAAQKYNHESIDNKGVSMWMLIGIGAISMLVLGLGLGVIVWLWRRQRRSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULW6</accession>
    <name>F9ULW6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ordered locus">lp_0737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637821.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888719.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0737"/>
    <dbReference type="EnsemblBacteria" id="CCC78205">
        <property type="protein sequence ID" value="CCC78205"/>
        <property type="gene ID" value="lp_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="49393070"/>
    <dbReference type="GeneID" id="57024440"/>
    <dbReference type="GeneID" id="66448708"/>
    <dbReference type="KEGG" id="lpl:lp_0737"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.621"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_9"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="PhylomeDB" id="F9ULW6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-640-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="188" mass="21725" checksum="5CEE8EAB3B436B80" modified="2011-10-19" version="1">MLNFNIRGENIEVTQAIRDYVQKRVGKLQKYFDNNVDSIAHVNLKVHPDKTAKVEVTIPLPYLVLRAEETSPDMYASVDLVTDKLERQIRKYKTKVNRKSREKGYKAIDFAATDETVAAADNDQDDKLDVVRTKRVALKPMDNEEAILQMDMLGHDFFIYEDAETDAINIVYRRNDGRYGLIETDDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULX9</accession>
    <name>F9ULX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stress-responsive transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101151.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888732.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0752"/>
    <dbReference type="EnsemblBacteria" id="CCC78218">
        <property type="protein sequence ID" value="CCC78218"/>
        <property type="gene ID" value="lp_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0752"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.633"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143433_0_0_9"/>
    <dbReference type="OMA" id="HNVHEED"/>
    <dbReference type="PhylomeDB" id="F9ULX9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-653-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR007168">
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11661" checksum="10212C09E2514E21" modified="2011-10-19" version="1">MKSNTKQKLTKSNNRVFAGVLGGIAEYLNWNAMILRVLYVILTLVTHGFGVLVYLVLMTIIPSKPDNTGFFEQMRQSTGTQAKPQAHGRKEIHNVHEEDDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101156.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0785"/>
    <dbReference type="EnsemblBacteria" id="CCC78245">
        <property type="protein sequence ID" value="CCC78245"/>
        <property type="gene ID" value="lp_0785"/>
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    <dbReference type="KEGG" id="lpl:lp_0785"/>
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    <dbReference type="eggNOG" id="COG1052">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_9"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="PhylomeDB" id="F9UM06"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-680-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="109"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="34814" checksum="6FAED1F16E509A20" modified="2011-10-19" version="1">MTKVFIAGQLPAQANTLLLQSQLVIDTYTGDNLISHAELIRRVADADFLIIPLSTQVDQDVLDHAPHLKLIANFGAGTNNIDIAAAAKRQIPVTNTPNVSAVATAESTVGLIISLAHRIVEGDHLMRTSGFNGWAPLFFLGHNLQGKTLGILGLGQIGQAVAKRLHAFDMPILYSQHHRLPISRETQLGATFVSQDELLQRADIVTLHLPLTTQTTHLIDNAAFSKMKSTALLINAARGPIVDEQALVTALQQHQIAGAALDVYEHEPQVTPGLATMNNVILTPHLGNATVEARDGMATIVAENVIAMAQHQPIKYVVNDVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM84</accession>
    <name>F9UM84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine ABC transporter, ATP-binding protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="primary">glnQ2</name>
        <name evidence="5" type="ordered locus">lp_0878</name>
    </gene>
    <organism evidence="5 6">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888837.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0878"/>
    <dbReference type="EnsemblBacteria" id="CCC78323">
        <property type="protein sequence ID" value="CCC78323"/>
        <property type="gene ID" value="lp_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0878"/>
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    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-759-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="27462" checksum="D21E4BA1A00A3FC1" modified="2011-10-19" version="1">MSMIEFHDVEKYYGDFHALKNINLTINEGEKVVLIGPSGSGKSTLIRTVNGLERVQSGQLLVNGFDLADRKTDMNKIRKNVGMVFQHFNLYANKTVLENIMIAPRLVLKRPEDENKKLAMDLLDSVGLADKANSLPSQLSGGQSQRIAIARSLAMKPKCLLFDEPTSALDPEMIDDVLNVMKSVAEDSSMTMLVVTHEMGFAREVADRVIFMADGEILEDDAKEKFFDGQPSNERARQFLSKIITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
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    <gene>
        <name evidence="1" type="primary">pgm4</name>
        <name evidence="1" type="ordered locus">lp_0901</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101194.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888857.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0901"/>
    <dbReference type="EnsemblBacteria" id="CCC78343">
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        <property type="gene ID" value="lp_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0901"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.763"/>
    <dbReference type="eggNOG" id="COG0406">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="OMA" id="GQTYFNI"/>
    <dbReference type="PhylomeDB" id="F9UMA4"/>
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    <dbReference type="Proteomes" id="UP000000432">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCC78343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="218" mass="24377" checksum="990AB22697F94600" modified="2011-10-19" version="1">MATFSVYMIRHGQTYFNKYRRMQGWCDSPLTAVGEQDARNAGKMLNGIDFDAVYASDMTRAMRTAELILPASGNTDLTVQPMAAFREAFYGYFEGDDTSQTWFMVGAPHQAPSLSAIIEQYGIEKAKDFCKEADPFHRAENNAEFWQRVTGGLDTLRAHHHDGDKVLVVSHGNTIYSIAARFAALTSPARPQNGSVTKFTISDNDVTLDYFGRKDHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC7</accession>
    <name>F9UMC7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0928"/>
    <dbReference type="EnsemblBacteria" id="CCC78366">
        <property type="protein sequence ID" value="CCC78366"/>
        <property type="gene ID" value="lp_0928"/>
    </dbReference>
    <dbReference type="GeneID" id="57024607"/>
    <dbReference type="GeneID" id="66448866"/>
    <dbReference type="KEGG" id="lpl:lp_0928"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.786"/>
    <dbReference type="eggNOG" id="ENOG5030AKT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2935681_0_0_9"/>
    <dbReference type="OMA" id="FPAMLLV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-802-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="60" mass="6450" checksum="2D21C1A745064040" modified="2011-10-19" version="1">MSNAQYGFLIGLLLGIVWVLTSFSAVLLVAVLGLIGWAIGRFVHVDLAAVSQKLSEYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMF4</accession>
    <name>F9UMF4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888907.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0960"/>
    <dbReference type="EnsemblBacteria" id="CCC78393">
        <property type="protein sequence ID" value="CCC78393"/>
        <property type="gene ID" value="lp_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0960"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.817"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682943_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-829-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="410" mass="45699" checksum="5281FE7486F1F318" modified="2011-10-19" version="1">MMPTNLTLLERKISNNLNCLYFVNHPVYRIQKDHQLALASEYSLAGNVTEIICDEQQRYHILFVARKEIVLTEKKVAKVTNNQLGQDTVQFLATLGYQFPPAQPAGELSQPTILPSPTELSECPTAYVIIDCEFGTRFRRNGSAKAVSWHVIESPELRASIFQLSAIGFSHHTQTAPFFNRYFDDPNFLPDKKLAGLSATGLTTVAYEAQGDPLTILKAFIQQVIQPQLPLVFWDQTQDMKHIRLLLTQYYQQLTPTEQQLVSRPVTIFDAQAYTNTLINRGNHKVGSHDLPLNGLAALFNISNPHQHNAIWDVQTTELVMVKLAELTHQTPVITTPPAPIALPATVPAVVPSIQTPSPTPQHASHAQVHQLRARGKTYREIAAATGFSISGINYILKKARSIPTRSESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMX3</accession>
    <name>GLPF4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol uptake facilitator protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">D/L-lactic acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Lactic acid channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glpF4</name>
        <name evidence="6" type="ordered locus">lp_1175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Is involved in the cellular racemization of lactate and lactate metabolism, but has likely a more general physiological role. The transported molecule is indeed lactic acid and not the lactate anion, in agreement with the assumption that, with very few exceptions, MIPs (major intrinsic proteins) only facilitate the transport of uncharged solutes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells lacking this gene show a decreased lactate transport ability.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643315.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889076.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UMX3"/>
    <dbReference type="SMR" id="F9UMX3"/>
    <dbReference type="STRING" id="220668.lp_1175"/>
    <dbReference type="EnsemblBacteria" id="CCC78562">
        <property type="protein sequence ID" value="CCC78562"/>
        <property type="gene ID" value="lp_1175"/>
    </dbReference>
    <dbReference type="GeneID" id="57024809"/>
    <dbReference type="GeneID" id="66449064"/>
    <dbReference type="KEGG" id="lpl:lp_1175"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.993"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_9"/>
    <dbReference type="OMA" id="MSAGNME"/>
    <dbReference type="PhylomeDB" id="F9UMX3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1005-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441645" description="Glycerol uptake facilitator protein 4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="5">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="25367" checksum="513701808D5D62C5" modified="2011-10-19" version="1">MIHQLLAEFMGTALMIIFGVGVHCSEVLKGTKYRGSGHIFAITTWGFGITIALFIFGNVCINPAMVLAQCILGNLSWSLFIPYSVAEVLGGVVGAVIVWIMYADHFAASADEISPITIRNLFSTAPAVRNLPRNFFVEFFDTFIFISGILAISEVKTPGIVPIGVGLLVWAIGMGLGGPTGFAMNLARDMGPRIAHAILPIKNKADSDWQYGIIVPGIAPFVGAACAALFMHGFFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN27</accession>
    <name>F9UN27_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101326.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78616">
        <property type="protein sequence ID" value="CCC78616"/>
        <property type="gene ID" value="lp_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1234"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1046"/>
    <dbReference type="eggNOG" id="ENOG50309Y8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246587_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1057-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="101" mass="11997" checksum="795E09033C9BC4B1" modified="2011-10-19" version="1">MNDDWITVFPADYNNSYHLILKRGTAHYAYYYFKVDKLDQRVIFYDDIERSGISIKTQITRTFMRALVKAIDWHPVGNSIIIEIYPVDRQETKAMRLSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN30</accession>
    <name>F9UN30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101328.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1237"/>
    <dbReference type="EnsemblBacteria" id="CCC78619">
        <property type="protein sequence ID" value="CCC78619"/>
        <property type="gene ID" value="lp_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1237"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1049"/>
    <dbReference type="eggNOG" id="ENOG5030BQQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2862190_0_0_9"/>
    <dbReference type="OMA" id="HWLAGRE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1060-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="64" mass="7447" checksum="149A6D3FB724B62A" modified="2011-10-19" version="1">MYIWMNTHVLLTVTNSNQRQFHQHWLAGRELTDSDLTSLITILTPLFAEKIISITVRTITEFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN40</accession>
    <name>F9UN40_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
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    <gene>
        <name evidence="2" type="primary">tagD2</name>
        <name evidence="2" type="ordered locus">lp_1248</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.39" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889143.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1248"/>
    <dbReference type="EnsemblBacteria" id="CCC78629">
        <property type="protein sequence ID" value="CCC78629"/>
        <property type="gene ID" value="lp_1248"/>
    </dbReference>
    <dbReference type="GeneID" id="57024869"/>
    <dbReference type="KEGG" id="lpl:lp_1248"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1059"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_2_9"/>
    <dbReference type="OMA" id="AFFNYQQ"/>
    <dbReference type="PhylomeDB" id="F9UN40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1070-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_trans-like"/>
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        <property type="entry name" value="G3P_cytidylTrfase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01518">
        <property type="entry name" value="g3p_cytidyltrns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="132" mass="15475" checksum="06F7FB227451E732" modified="2011-10-19" version="1">MKKVITYGTFDLLHKGHIRLLKRARALGDHLTVCVSTDEFNAEKGKHAYTSYEDRKYILQAIRYVDEVLPEKSWDQKIRDVVDNDIDIFVMGDDWRGKFDFLKDYCEVVYLPRTEGISSTRIKHDLGMQSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB0</accession>
    <name>F9UNB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein, EamA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101362.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889213.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1343"/>
    <dbReference type="EnsemblBacteria" id="CCC78699">
        <property type="protein sequence ID" value="CCC78699"/>
        <property type="gene ID" value="lp_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1343"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1131"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_9"/>
    <dbReference type="OMA" id="TYALYSW"/>
    <dbReference type="PhylomeDB" id="F9UNB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1157-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="312" mass="33722" checksum="4FC0F873923A0A5E" modified="2011-10-19" version="1">MKRLVGTLCGIISAALFGLGGILAQPLLSEQVLTPQQIVLLRLLIGGAMLLLYRNLFFKQARKSTKKIWTHWRILTRIMIYGIAGLCTAQIAFFSAINYSNAAVATVFQSTSPFILLVFTALKAKRLPSLLAGMSLISALMGIWLIVESGFKTGLIKPEAIIFGLIAAIGVILYTKLPVPLLNQIAAVDILGWALVIGGVIALIHTPLPNLVRFSKTQLLAVLIIVILATVVAYDLYLESLKLIDGFLATMTGLFEPISSVLFGMLFLHQILVPQALVGIILVVGAIMILNLPHHITAPVPSKTCQCTMSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK2</accession>
    <name>F9UNK2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA translocase FtsK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ftsK1</name>
        <name evidence="10" type="ordered locus">lp_1461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCC78791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889305.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1461"/>
    <dbReference type="EnsemblBacteria" id="CCC78791">
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        <property type="gene ID" value="lp_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1461"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1224"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_12_4_9"/>
    <dbReference type="PhylomeDB" id="F9UNK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1252-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="9">
        <location>
            <begin position="662"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="679"/>
            <end position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="996" mass="103760" checksum="C292A55F0FC70B9A" modified="2011-10-19" version="1">MNHYDGPAFFRKYRFNKPQVNNSAASQSTPVAASASPQSTAGAPSAAPKRPASQTSAKQVTSQATTSSSSAATSATLFNGGTHGTFHPSRVPAQLSAALTNGGIIQDHDDRNYLEIEASLHKRPETFLLFADAAANDLPAVDLQQPLSDSGTDTSQVEHPSDSAVLSQAERKMASSVDPTTVTSQAASSVAAQTVVANTSQTGSDSTVSAASATVVRPTEVFEPTTPELAVSAAAINTPKTDDSVVVTAPTEVFEPTDPSLAASAAAINAPSAVSSAISVGPTEVFEPTDPSLAASAAAINAPSAVSSAVSAGPTEVFEPTDPSLAASAAAINAPSAVSLAVSAGPTEVFEPTDPALAESAATVNAAADHDKIESAATSATPKSAHGLGLSLGDIMTAEHDAQADLALFKDQPTTAASAAPQSSTAQTRSHVNEEPYQPVGMRPTSTSPAVTSATATPVSVVASTVPSQESGGAASVTMAPSQAATSAVTTSPALSETSAVASQPELVHSGGSAAPVLEDKELAAYHLPPLNLLKAPIVANESEMDDWIEQKASALDESLDAFGVNANVVDWTIGPTVTQFQVKPARGVKVSKITNLNDDLKLALAAKDIRIEAPIPGRNTIGIEIPNAKSRPVMLSEVLDSDKFRDSKSPLTVALGVDLFGQPQVTDLRKMPHGLIAGATGSGKSVFINSILVSILYKANPQQVKLLLIDPKAVELAPYNEIPHLLAPVISEPKAASAALKWVVDEMDNRYDKLAAGGARNIEQFNKLADEHDEPALKMPYIVIVIDELADLMMVASSEVQDYIARITQKARAAGIHLLVATQRPSVDVVTGLIKNNIPTRVAFMVASQIDSRTILDASGAERLLGRGDMLYLGNGQPAPIRLQGTFVDSEIDSITQFVRDQAAPHYEFQPDSLMKHEEAARNEDDLMPEALAYIADEDTMSTSKLQRNFSIGYNRAANIIDDLESRGYVSAAKGSKPRDVYFTAADLTKLQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM5</accession>
    <name>F9UNM5_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101432.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889328.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1486"/>
    <dbReference type="EnsemblBacteria" id="CCC78814">
        <property type="protein sequence ID" value="CCC78814"/>
        <property type="gene ID" value="lp_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1486"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1248"/>
    <dbReference type="eggNOG" id="ENOG5030A5Y">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2273794_0_0_9"/>
    <dbReference type="OMA" id="YVTHATL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1275-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="102" mass="11138" checksum="7187135E672078C2" modified="2011-10-19" version="1">MAHNVSQDEELLGILRDVATHRFHQGRQVNPNSMLYQTVSVAVERGYLNDAQLDDNYSHTLASIDLTKATLTDAGTDKLQALTTVDDTVATDDANAPTRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNS0</accession>
    <name>F9UNS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640295.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889373.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1535"/>
    <dbReference type="EnsemblBacteria" id="CCC78859">
        <property type="protein sequence ID" value="CCC78859"/>
        <property type="gene ID" value="lp_1535"/>
    </dbReference>
    <dbReference type="GeneID" id="57025130"/>
    <dbReference type="GeneID" id="66449426"/>
    <dbReference type="KEGG" id="lpl:lp_1535"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1293"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_3_1_9"/>
    <dbReference type="OMA" id="KWTIYQL"/>
    <dbReference type="PhylomeDB" id="F9UNS0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1320-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20737" checksum="4A3DA9150767E9AD" modified="2011-10-19" version="1">MKWSLSQLKTYRETPLQFDEALDLKHSLMSRYPEIIDVKSVHATGLASYDKDNVLITAKIDAMLTLPSSRSLTPVDVPLAFQMTEYYVPQGTDLSRFDEETDTVIILPEDDILDFDVAVEDNILIHIPMQILSEAEQDGAPMPTGKGWEVLSEDDQALQAAELKTVDPRLAKLKNLFPDQEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP40</accession>
    <name>F9UP40_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">accB2</name>
        <name evidence="6" type="ordered locus">lp_1676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640414.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889493.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1676"/>
    <dbReference type="EnsemblBacteria" id="CCC78979">
        <property type="protein sequence ID" value="CCC78979"/>
        <property type="gene ID" value="lp_1676"/>
    </dbReference>
    <dbReference type="GeneID" id="57025250"/>
    <dbReference type="KEGG" id="lpl:lp_1676"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1415"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_2_9"/>
    <dbReference type="OMA" id="TAYWAPE"/>
    <dbReference type="PhylomeDB" id="F9UP40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1442-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16350" checksum="04ACED7686B20F1E" modified="2011-10-19" version="1">MSMTDTEAMTALINQFNQSSAQVMDVKTTTFELHLNKQAETAETNSARSQPAVTDSAVPVVKPTTEVATQSGTTMVTAPLVGVAYLAADPKQAPFVQVGDRVKSGETLCVIEAMKMINEVPSPVSGIVKEVLIKNATMVEFDEPLFAIEETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP49</accession>
    <name>F9UP49_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889502.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1686"/>
    <dbReference type="EnsemblBacteria" id="CCC78988">
        <property type="protein sequence ID" value="CCC78988"/>
        <property type="gene ID" value="lp_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1686"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1424"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_1_9"/>
    <dbReference type="OMA" id="AFICATR"/>
    <dbReference type="PhylomeDB" id="F9UP49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1451-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18666" checksum="BBC6C8AE693BDE9A" modified="2011-10-19" version="1">MEPIHISQTLSITNHRVFSADLNEHDTVFGGKILTTIDDNSSIAASRVARIETVTVSVDQVNFLLPFRLQDSMCAESYVSGVGHRSIEVFTKIIGEHLKTGERFLGLTCFSTFVVTDRNIELPLLVADKPEYTFVAQGYQERQAARLAKLKRQQDFNAHISVELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP89</accession>
    <name>F9UP89_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mvaD</name>
        <name evidence="11" type="ordered locus">lp_1734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889542.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1734"/>
    <dbReference type="EnsemblBacteria" id="CCC79028">
        <property type="protein sequence ID" value="CCC79028"/>
        <property type="gene ID" value="lp_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1734"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1463"/>
    <dbReference type="eggNOG" id="COG3407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_9"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="PhylomeDB" id="F9UP89"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1491-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MDD_C" evidence="10">
        <location>
            <begin position="178"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35238" checksum="ECED3328FA6AEE04" modified="2011-10-19" version="1">MKTVTAKAHTNIALVKYWGKKDAALMLPQNGSISLTLDHFYTQTSVTFDEHLDTDQIYFNHQHLPTGKSARISQFLDLIRQRSGQTNYATVKTENHVPTSAGLASSASGFAALAGAASRAAGLQLDAADLSRLARRGSGSATRSIFGGFVEWHAGHDDQSSYAEVLQDPVDWDIQMIAVVLKATKKTISSTDGMARVVATSPYYPAWITTAETDLKRMRQAIADRDLTTVGQIAETNAMRMHALNLSAEPAFNYFTADTLTAIQAVNDLRSHGINCYYTLDAGPNVKIICAGQDTDTIMTGLQQHFDADQLIVAKPGPGITITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP91</accession>
    <name>F9UP91_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889544.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1736"/>
    <dbReference type="EnsemblBacteria" id="CCC79030">
        <property type="protein sequence ID" value="CCC79030"/>
        <property type="gene ID" value="lp_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1736"/>
    <dbReference type="HOGENOM" id="CLU_2330231_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1493-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="11166" checksum="2BEDF530AE3BFC89" modified="2011-10-19" version="1">MIRNQSDNDEKEVELLVTGYVAQNSLIRKVNFGQQCRLFKRAYSADCVMADVRRDTFMNFIVAQSYSWPVGPVSARCPQTDEFGLRVGRAEFPAPNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA2</accession>
    <name>F9UPA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_1748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889555.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1748"/>
    <dbReference type="EnsemblBacteria" id="CCC79041">
        <property type="protein sequence ID" value="CCC79041"/>
        <property type="gene ID" value="lp_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1748"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1474"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_2_0_9"/>
    <dbReference type="OMA" id="QAFWRVA"/>
    <dbReference type="PhylomeDB" id="F9UPA2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1504-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="55"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="345"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="553" mass="61234" checksum="D4633FC18662062E" modified="2011-10-19" version="1">MSNHQIRLSLSIITSCLLATLIIGPLVALIGQTLVGQSPSQLWSQLTQPTNRVSIQHSLFLSGGTVVGTTLLATPLAWIMTHTRLTKLAWLHWLLLVPFMTPPYINAMGWLYFFQPHGLLAQLNPSWHHQFQWLFSPFGMVIIMSLHLYPVAYLGLRAALMQFNQRWLQAAEVHGVNTWQRLVRITLPIMLVPYLAVWILVFTKTLAEFGTPATFGRSIHFEVLTTTIQRDLSQWPLDFQNGVLTGTLLLTIALIAWGIQQWLLRRPAVKFTGQRSASQYRQLGVTTLAGTFVTLVISIAIVLPFSAIVLQSLLKQRSLGWSPSNLTLVHYIDLLRFDSPAWQAIVTTVGLALLISSLNVIVGLFLSVGSLTKRFPKWLRQLCHTLGALPLAIPNVVLALSLMMLFSQVLAFTKLYGTLTILLIADVTLFLPTTVQYLTTALKAFDSELLASARIFEPSFGRIILKIALPILWPALLNSFVMAFIATSRELVVALLLLPSGMTTVSTFIYQSFEQGEAAAGMALAVLTVALTFIGLIAANHLQSATKPVRQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB6</accession>
    <name>F9UPB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase, GNAT family, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1765"/>
    <dbReference type="EnsemblBacteria" id="CCC79055">
        <property type="protein sequence ID" value="CCC79055"/>
        <property type="gene ID" value="lp_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1765"/>
    <dbReference type="HOGENOM" id="CLU_3169556_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="47" mass="5206" checksum="83950EFB14A7575F" modified="2011-10-19" version="1">MQLQIRRFKTTDAPAAAALIARALLTSNQGDYPKAYLDRLITQMTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ4</accession>
    <name>F9UPJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxy-terminal proteinase, S41 family,peptidoglycan-bound</fullName>
            <ecNumber evidence="6">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpA</name>
        <name evidence="6" type="ordered locus">lp_1864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101574.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889647.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1864"/>
    <dbReference type="MEROPS" id="S41.007"/>
    <dbReference type="EnsemblBacteria" id="CCC79133">
        <property type="protein sequence ID" value="CCC79133"/>
        <property type="gene ID" value="lp_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1864"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1570"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_0_9"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="PhylomeDB" id="F9UPJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1595-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="492" mass="53234" checksum="55F895DDBA832982" modified="2011-10-19" version="1">MPEEPKQTNPHIKKVPRPKRRVGLWTYIISIVVALGIGVGGTYWLIGRQVNAQLSSMQQTSKAMKKIESVYETINENYYKPVNANKLANGAINGMVNSLGDKFSEYMDKSETESLNDTIDSSFSGIGAQVQKSGNYVQIISPIAGTPAKKAGLKPKDIIKAVNGKSVAGKTLTQAVSMMRGKIGTTVKLTIERSGQTFTVSLKRAKIPVTTVDYKLVGGDKKIGYITVSTFSTNTAKEFKTALKALDKKGAKKLVIDMRGNPGGLMTAALKMASIFLKNGKTIMQVQARDGSTEKYTASKKYDGGFKETKSTTVLIDGGSASAAEIFSAALHQSAGVKLVGSQSYGKGTVQTVTTFNDKTEMKITVAKWLTPNGTWINKKGLTPDVKADEPSYASLTVISKVSDLQADKVNSNVKTFQKYLQALGYFKGTVNGYFGDSTTSAVKQYQKHAKLTVNGKVDKQTLTKIETELANKISDNDRAYDAAMKLIEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL6</accession>
    <name>F9UPL6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB</name>
        <name evidence="5" type="ordered locus">lp_1888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640595.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889669.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1888"/>
    <dbReference type="EnsemblBacteria" id="CCC79155">
        <property type="protein sequence ID" value="CCC79155"/>
        <property type="gene ID" value="lp_1888"/>
    </dbReference>
    <dbReference type="GeneID" id="57025481"/>
    <dbReference type="GeneID" id="66449713"/>
    <dbReference type="KEGG" id="lpl:lp_1888"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1591"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_9"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="PhylomeDB" id="F9UPL6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1617-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="26622" checksum="FA93592C18E881C9" modified="2011-10-19" version="1">MAERLQKVMAEAGIASRRKSEVLITSGHVKVNGKTVTTLGVKVEPSDHVEVDGVPLNAEKLVYYLFYKPRGVVTTVHDEKGRKTVLDFFEDVPERIYPVGRLDYDTSGLLIMTNDGALANRLTHPKYEVKKTYLAKVEGVPTNADLKQLRLGVEIDGRKTAPAKSNLLDSDHKKNNALVQLTIHEGHNHQVKKMLAAVGHPVTKLKRERYGVLDLQSLQPGEYRKLKPIEISKLKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ0</accession>
    <name>F9UPQ0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889703.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1929"/>
    <dbReference type="EnsemblBacteria" id="CCC79189">
        <property type="protein sequence ID" value="CCC79189"/>
        <property type="gene ID" value="lp_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1929"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1626"/>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147269_0_0_9"/>
    <dbReference type="OMA" id="NAFQHIW"/>
    <dbReference type="PhylomeDB" id="F9UPQ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1651-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016996">
        <property type="entry name" value="UCP032441"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032441">
        <property type="entry name" value="UCP032441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="129" mass="15560" checksum="9596BEBE245E6D90" modified="2011-10-19" version="1">MSQWQQDWAYQKYWVMAHSQQHYNAIRQLARHNDWSATKQERYQQLLAEAEQITPTKATLTTAYQHVWGYFKKQCTLAEKQRYLNLLTNLTPAHDQLGPFLWQLTVKYEVAYLLASRLLRTFDQHENQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW3</accession>
    <name>F9UPW3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101622.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889766.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2004"/>
    <dbReference type="EnsemblBacteria" id="CCC79252">
        <property type="protein sequence ID" value="CCC79252"/>
        <property type="gene ID" value="lp_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2004"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1693"/>
    <dbReference type="HOGENOM" id="CLU_1127962_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1716-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="28787" checksum="BE7B4C12BA7939E6" modified="2011-10-19" version="1">MNPYFLIIGMVLFGIAFIIYLLVKDKDMQLIVLWVILCFQGIIVLLGITIIIFSLIESLAQTSFSNKELFELLYKTMVKFVIAILTIVTAYIAYQATMSASRESKLQALHSESGWRTALLEVLDHVDWGPNDLEKIRNRINVKWSSNINFDSNNMHDNYIKGLMKEELNKLSHKERITYRDSFKLRQLVRMLLDNDFQVQTGHEIEYCDANSVNRYLELPSRDNEKDVCDMDNIQKMIDVYRKDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW7</accession>
    <name>F9UPW7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1-5N</name>
        <name evidence="2" type="ordered locus">lp_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2009"/>
    <dbReference type="EnsemblBacteria" id="CCC79256">
        <property type="protein sequence ID" value="CCC79256"/>
        <property type="gene ID" value="lp_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2009"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_13_0_9"/>
    <dbReference type="OMA" id="NKDTHKG"/>
    <dbReference type="PhylomeDB" id="F9UPW7"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="143" mass="15970" checksum="563CFC27FDBDFE27" modified="2011-10-19" version="1">MSDMSQDHSTKVLLQIKDPNITDLVVQEATNGSLQVLAKLTYPVTVCARCGKRSMVKNGFKTVHIRIPRISERVTILNLKKQRFICKNCGKSSLTTTTLVKKHHQISENSLHAIDLSLTEDRTMASIAAQYNVSTSFVQLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPY0</accession>
    <name>F9UPY0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pbpX2</name>
        <name evidence="2" type="ordered locus">lp_2021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.16.4" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2021"/>
    <dbReference type="MEROPS" id="S12.A21"/>
    <dbReference type="EnsemblBacteria" id="CCC79269">
        <property type="protein sequence ID" value="CCC79269"/>
        <property type="gene ID" value="lp_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2021"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1708"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9UPY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1731-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="43331" checksum="15A1E12F8F6D2804" modified="2011-10-19" version="1">MKQSKLLVTVLLGLLIVGAGGGYYVYHTERQAAIAKKRQTDKALNKKAALKNSQLSRKVNQTTFLNNKNTDEQVTKILNLSHFVGSALVVKDDHVVYNRAFGYANKAKNQRNKVNSKYQILSIQKSMTAVGIMQLVQAGKVKLTDPISKYYPTLKHGRQTTLRQMLDMTTGFRLKSGSKKFLPENQVIDFAAHNVFYYPDKNGINNYSSVNFLLLAGIIRKVTGQSYQHFFTTRFIDKLNLKETGFLIHGQGRNATTGYRALADQTIPNYDQTMPESKAQMANELGTGQVYMSTADLFTVESAILKGQLLSKKNVAILHTRTATGEYGGGVYNMSNGIRSHGLGYGYESSVFLSPDGKTGVVLLSNYYRKAAGSQAAAQKIFTELMKGDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQI8</accession>
    <name>F9UQI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641529.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889991.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2269"/>
    <dbReference type="EnsemblBacteria" id="CCC79477">
        <property type="protein sequence ID" value="CCC79477"/>
        <property type="gene ID" value="lp_2269"/>
    </dbReference>
    <dbReference type="GeneID" id="57025814"/>
    <dbReference type="KEGG" id="lpl:lp_2269"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1920"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099404_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UQI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1962-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019642">
        <property type="entry name" value="DUF2507"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10702">
        <property type="entry name" value="DUF2507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="227" mass="25722" checksum="0E2D3601C2B2677A" modified="2011-10-19" version="1">MVFFEIDFKPDQLRRNCKVSVDKLKKTDTLVETGYNNDYTVARVPRFFAWKGIIMTNDFYSQFAGNSIKASILSVEILRDALIPKLLGDDSSGILYWAGKDLARQFPVASDDDLVTFFEQTGWGHLVVITTTDDLITYELTGEPVARRSATIKSPDFMLETGFLAEQSALRTNCVSEAKITFQNRMRLRISVTIDHNQPIVNHDPATPIEIVRPQVELDDEQPEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM7</accession>
    <name>F9UQM7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ordered locus">lp_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641486.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890030.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2320"/>
    <dbReference type="EnsemblBacteria" id="CCC79516">
        <property type="protein sequence ID" value="CCC79516"/>
        <property type="gene ID" value="lp_2320"/>
    </dbReference>
    <dbReference type="GeneID" id="57025852"/>
    <dbReference type="KEGG" id="lpl:lp_2320"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1961"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQM7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2000-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="78"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="23607" checksum="7D422BCC48DD120F" modified="2011-10-19" version="1">MTMISEEQIPTAQVRELMQAYFGTFLPNDAVTSAMQAFEREYPIEDAIEWLHESSENPRWQGLIVALRCGQLLPRPSRLILGQVYGSEQLGAVLARDFANLEQEQLQLLCLDTKNQVIKRQVVFQGTLNSCPAQPREIIKVALTTPTARVVIAHNHPSGDVTPSKKDVEFTKRLQLACELMGLPLLDSFIIGVNDYFSFAEQGVLNCNTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW8</accession>
    <name>F9UQW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2428"/>
    <dbReference type="EnsemblBacteria" id="CCC79607">
        <property type="protein sequence ID" value="CCC79607"/>
        <property type="gene ID" value="lp_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2428"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2052"/>
    <dbReference type="eggNOG" id="ENOG5030BP6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2260147_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2093-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12505" checksum="88F4EE7FC19626CB" modified="2011-10-19" version="1">MNKAFILYRRFGMFYMIGYIFAGLILVIIASFGVVAAIETLREKRDTRPDIITNGNIKIKIDDGPTKYYRVDEVITNLNDKGSNEYQNDIKELVLHQLTDEDVAMKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX0</accession>
    <name>F9UQX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101762.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2430"/>
    <dbReference type="EnsemblBacteria" id="CCC79609">
        <property type="protein sequence ID" value="CCC79609"/>
        <property type="gene ID" value="lp_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2430"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2053"/>
    <dbReference type="HOGENOM" id="CLU_2260209_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2095-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="103" mass="11663" checksum="A088CD0295E98172" modified="2011-10-19" version="1">MKYEAKMEDVAVKSNYPIDIERVKELVEWSLPSWTKQVIIEGPLADDNWEGGDTVGDLINELKKLPEDMPVECDYAGMSVETVRHQGPDDETLYLYSALVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX9</accession>
    <name>F9UQX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646617.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890188.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2506"/>
    <dbReference type="EnsemblBacteria" id="CCC79674">
        <property type="protein sequence ID" value="CCC79674"/>
        <property type="gene ID" value="lp_2506"/>
    </dbReference>
    <dbReference type="GeneID" id="57025938"/>
    <dbReference type="GeneID" id="66450225"/>
    <dbReference type="KEGG" id="lpl:lp_2506"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2111"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="OMA" id="LAEVWDW"/>
    <dbReference type="PhylomeDB" id="F9UR35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2166-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="27557" checksum="A94939F74BC6A5D3" modified="2011-10-19" version="1">MKLLMIEDNKSVSEMMAMFFKKEKWDAHFAYDGNEAVEMFNEDVDGWDMVTLDLNLPGKDGMQVSADIRKASPTVPIIMLTARDSESDQVLGLEMGADDYVTKPFSPITLIARIKALHRRADLAKTTPADQPASTVSSFDVQTDHFKLNTKTREAYLADKQIQDLTPKEFDLLKTLAQKPRQVFSREQLLQLVWDYEYYGDERTVDAHIKKLRQKIEKAGPQIIQTVWGVGYKFDDSGVDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR45</accession>
    <name>F9UR45_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, NlpC/P60 family,gamma-D-glutamate-meso-diaminopimelate muropeptidase</fullName>
            <ecNumber evidence="3">3.4.19.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.11" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101812.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890198.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2520"/>
    <dbReference type="MEROPS" id="C40.009"/>
    <dbReference type="EnsemblBacteria" id="CCC79684">
        <property type="protein sequence ID" value="CCC79684"/>
        <property type="gene ID" value="lp_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2520"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2121"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_13_2_9"/>
    <dbReference type="OMA" id="YEEKLWL"/>
    <dbReference type="PhylomeDB" id="F9UR45"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2177-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="173"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="32930" checksum="C469E3970EA3C0D8" modified="2011-10-19" version="1">MQSTRIIAAVANVWRQPNNTSIDTPALANVGLQPWLAQLSDEDTVALERDNRIVTQALFNDVFLVEQFVNGWAYGYVVNQADSRHPQGYPGWVWAAQLSTVPLPVQTGPMITIRRGFTPLLCLDGRTFLNLSLGTELPVISSKDHRYYTVQTPLGTGKIAKRATQFAFRTARLTPGATLVRLGEEFLDLRYLWGGISAYGFDCSGFVYTLHRSLGIRLPRDAQDQIKQGVAVDIANVQLGDLCFFAHNHGNGAVHHVALYAGDGWLLHAPTPGKHVTYLQLASTYLQDELVAVKRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR79</accession>
    <name>F9UR79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646586.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890232.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2564"/>
    <dbReference type="EnsemblBacteria" id="CCC79718">
        <property type="protein sequence ID" value="CCC79718"/>
        <property type="gene ID" value="lp_2564"/>
    </dbReference>
    <dbReference type="GeneID" id="57025982"/>
    <dbReference type="KEGG" id="lpl:lp_2564"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2154"/>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042608_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2210-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021192">
        <property type="entry name" value="UCP031578_Vanz/RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031578">
        <property type="entry name" value="Uncharacterised_Vanz_RDD-cont"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="6">
        <location>
            <begin position="65"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="230"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="387" mass="44894" checksum="950414121F2E16DD" modified="2011-10-19" version="1">MHELITKLYQLALSSHIVSTLLEPVHIVILALPIMTLLLAMIILTIQLRTRQTLSERNLISTYSFIWYLAAAYLLIILPLPTRSSVASLTTAEYNLQPFYFLTQLKALTPFELGDPSTWLAAFKSDTFFQPFFNILLFMPIGAYLKWRHRWPLWLITLTSFSISLFFETTQLTGLYGYYSRAYRMFDVDDLMMNTLGGIVGAGCLHLIPNQWRNRDHSTRLNWQEHPINWRRIGALVIDWLAIAAFDTVYFVLVKHFNWPLPHDFRWLYLADIILFFIGPAWCWHGKTIGGRLLNSQIVTISGHQANLWQLLIHYSGLYLIGLPLLFLDLWLFNRLGNVPSATLNRLDVYLVVVSVILLIISYDLLLALFSRSHQLWCEKLSRTTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR81</accession>
    <name>F9UR81_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890234.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2566"/>
    <dbReference type="EnsemblBacteria" id="CCC79720">
        <property type="protein sequence ID" value="CCC79720"/>
        <property type="gene ID" value="lp_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2566"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2156"/>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128703_2_0_9"/>
    <dbReference type="OMA" id="YATGQKR"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2212-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="12526" checksum="F18136078F23EA01" modified="2011-10-19" version="1">MPSRVKVTDTNDYINKAAIAAQPILSTLAQLITSELLDFTAKIKWNLPFYEHDKQYVSIAAYQAHVSLSISADLDDATLTAAKTAGYATGQKRLNIGLDQPVPVALVRQVLQLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA9</accession>
    <name>F9URA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101848.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2601"/>
    <dbReference type="EnsemblBacteria" id="CCC79748">
        <property type="protein sequence ID" value="CCC79748"/>
        <property type="gene ID" value="lp_2601"/>
    </dbReference>
    <dbReference type="GeneID" id="57026009"/>
    <dbReference type="KEGG" id="lpl:lp_2601"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2184"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_7_0_9"/>
    <dbReference type="OMA" id="WHPDFTD"/>
    <dbReference type="PhylomeDB" id="F9URA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2239-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="28014" checksum="CFFA6A62EE191890" modified="2011-10-19" version="1">MVAKLAVFDIDDTLLASNKTFLKSTLTSIKKLKQQQINVAIATGRNLAMAKAVIHKLDLNDFVLCNGSAAFANHQQVHEHTLSRDNMATLVAAADANNIDIIFESLDGLHAHTHLNEQTRRVLHTFRAPTVEYAPNYYLDNDIYQAMMFYPHQQDANLPHADEFSFVRFDVNGVDIIPKVGSKAQGVAKLAASLKVAPENVVAFGDNQNDREMLQSAGIGIAMGNAAPEIKAQADMTTTDCDHDGIENGLKSIGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ1</accession>
    <name>F9URJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase, EAL domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642599.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2714"/>
    <dbReference type="EnsemblBacteria" id="CCC79830">
        <property type="protein sequence ID" value="CCC79830"/>
        <property type="gene ID" value="lp_2714"/>
    </dbReference>
    <dbReference type="GeneID" id="57026090"/>
    <dbReference type="KEGG" id="lpl:lp_2714"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2270"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089605_0_0_9"/>
    <dbReference type="OMA" id="QRRIAIF"/>
    <dbReference type="PhylomeDB" id="F9URJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2321-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="32264" checksum="8082DD929BEA48FB" modified="2011-10-19" version="1">MSLAQLEIGLLWLTGSIAVIFILTIGTYYWYSRKRSNNYLENDDFNLRYFIQKQVDFRGRTTGYECLLRQQNTDGSWSLPPQLDSLPLQRVIFLLEDTFKALPDEAITLSINLEYEQIISPEFRYFVRWAIANIEPMHLAIEYTPQYQPRRINKRLFRRRIREARGYGMQFGIDNVGASLANLKNIQWLLKDIDTLKCSMRSFRKEDPSVWLDLNLQFWNQLSKENNIDLILMGIENEADEQLAEQLQISIRQGYLFGHPINPQQSTTKENHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK7</accession>
    <name>F9URK7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890360.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2733"/>
    <dbReference type="EnsemblBacteria" id="CCC79846">
        <property type="protein sequence ID" value="CCC79846"/>
        <property type="gene ID" value="lp_2733"/>
    </dbReference>
    <dbReference type="GeneID" id="57026106"/>
    <dbReference type="KEGG" id="lpl:lp_2733"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2286"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_0_9"/>
    <dbReference type="OMA" id="YGGVWAQ"/>
    <dbReference type="PhylomeDB" id="F9URK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2337-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="202" mass="22793" checksum="27F7AC3BEE2AFFC1" modified="2011-10-19" version="1">MHKFIAMVGTNSDESTNRKLLQYMQSHYADQAEIELMEIKGLPIFNKPENHEIPAQAQAMADKIEQADGVIISTPEYDHSAPAALLNALEWLSFHIQPFVDKPVMIIGASYGALGTSRAQAHLRQVLDSPELRARIMPSSEFMLGHSLQAFDDQGNLTDQQKATKLDGLFKDFQVFVEITKKLKNANATTYEEVREMDWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV1</accession>
    <name>F9URV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101934.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890454.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2849"/>
    <dbReference type="EnsemblBacteria" id="CCC79940">
        <property type="protein sequence ID" value="CCC79940"/>
        <property type="gene ID" value="lp_2849"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2849"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2382"/>
    <dbReference type="eggNOG" id="COG4152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="PhylomeDB" id="F9URV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2437-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="299" mass="33021" checksum="1C2A7F60661BC02D" modified="2011-10-19" version="1">MLSIAHIQKRFGTVQALNDVSFDVHDGEIMGLIGQNGAGKSTTFHSILNFLSFDGQITWNGQPLTADDYDQIGYLPEERSLMSKLTITQKIVYLARLKNQPARVTKGKIAAWMKRFAVKGQPTDKIDKLSKGNQQKVQLICTLIHDPKLIILDEPFSGLDPVNADLLKQAILDAKQRGAAIIFSSHDMSNVEAICDSLVMLRNGEAVLKGTVEDVRAQFGRTRLFLTTDWSQAQLADLPGVTTVTQQGARRFRLELADASVGPAIFDQVTAGHYIEEFSQQPPTLDEIFRTEAGGVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9US25</accession>
    <name>F9US25_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890528.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2942"/>
    <dbReference type="DNASU" id="1063394"/>
    <dbReference type="EnsemblBacteria" id="CCC80014">
        <property type="protein sequence ID" value="CCC80014"/>
        <property type="gene ID" value="lp_2942"/>
    </dbReference>
    <dbReference type="GeneID" id="57026285"/>
    <dbReference type="KEGG" id="lpl:lp_2942"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2457"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="EHALDPW"/>
    <dbReference type="PhylomeDB" id="F9US25"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2510-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="34175" checksum="5CB584E5B766393B" modified="2011-10-19" version="1">MTINDLQAFVMVYDLRHISNAAVELHLSQSELSKRMRALENELNIKLLDTHNKRRLQITPAGETFYHHAHKMITDYETMMHDLAPNRPTTFAKLIIGAIPISGQYNIAKKIATFDTQHPDTEIKIIEDEGDQIVKRLLSGELQAAIIRDTQTTQLQPTEFQKQPLLADELKIILPRDHPLATQPVIRIQDLARQKIATLPPGSGVYEPINALFAQQGMTPQFFFESTHIETLLGILNQNNVTFLFKQSVLPFMTEHVVMRSLAIPFISQLNFVYPQRTGNQLLTDLIDYLTVTAQENQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9US29</accession>
    <name>F9US29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642217.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890532.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2949"/>
    <dbReference type="EnsemblBacteria" id="CCC80018">
        <property type="protein sequence ID" value="CCC80018"/>
        <property type="gene ID" value="lp_2949"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2949"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2461"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820831_0_0_9"/>
    <dbReference type="OMA" id="YFHISKL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2514-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35353" checksum="C1AEEAC4250A42C4" modified="2011-10-19" version="1">MKKCPNCGTEIAANAKFCTHCGYDLTKATPASATANATSATATQTTTATTQAAVHTSTASANQQQSASAEKQAASRSAAADTTRTATNQQVQQLQSSAKNYFSWLLASWKNPSCEVRTESYFSYISFVIEALFMTLAAVTISNKFLTTANDSQSYFHISKLAFSTDLKIFLCLLIGMCFYLAVGYVTCLLGSRGTKVGFTTYMKRFGQLTNYAIIVNLLLWFASSLVNFSVDNFFTIAASFRWSIILLSVSVLVWQLGLIFVINKSVTQPLISRVYLALIAVLVVSLLFYFMDKIILQDLQTALLSHATDFANQIGNLFGSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9US74</accession>
    <name>F9US74_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100861.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888135.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0054"/>
    <dbReference type="EnsemblBacteria" id="CCC77621">
        <property type="protein sequence ID" value="CCC77621"/>
        <property type="gene ID" value="lp_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0054"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.43"/>
    <dbReference type="eggNOG" id="ENOG502ZWG2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074786_1_0_9"/>
    <dbReference type="OMA" id="HNSYTTF"/>
    <dbReference type="PhylomeDB" id="F9US74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-43-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021247">
        <property type="entry name" value="DUF2785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10978">
        <property type="entry name" value="DUF2785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="32116" checksum="8291C996F99D1806" modified="2011-10-19" version="1">MEAIINTLQATLNQTNLHFTDKQVTWLLNHVGALDPAIRDDLVYQLLGRGLESQAFTDSQKQQIIQPILKEHWLFKSIEEPTNDRVFLRSFTALLTTEILLSDTTHPWLTDTTRNQLFDDALTYLVREHDQRGFVRNKGWAHAIAHGSDLLGVAWCHPQFPISQSSRALSAIQTVVQRQNRVFVADEEARLAHPLIMALTAHKLTDNELCIWLQTTNQLLIKELNSTDLTSIYREHNWLRLIHHLYFWLPAKTIGRLIIEQISHQYYDKNGYLDFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9US90</accession>
    <name>F9US90_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, ASCH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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    </reference>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80096">
        <property type="protein sequence ID" value="CCC80096"/>
        <property type="gene ID" value="lp_3043"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3043"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2542"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737296_0_0_9"/>
    <dbReference type="OMA" id="INIAQNG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2589-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389004" evidence="1">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M10" evidence="2">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="38185" checksum="C39067A5DB9DFF1B" modified="2011-10-19" version="1">MRFPKRIFSTLATISLTTSFGLLSANASTKATTPMLGYRYDKQAANYQDLSSSDYYKDVWNNATASWKKAGFTWTKAATAKTTVSSYDGSSDMTLAGYNSVSYNKSTGEITSSKVRINRAVFEKYNYTKAERTNVAEHELGHALGIGHNNTDSVSVMNPANRYYTIQACDINGMKARYATTTTFDSVPNNPGEIITVTEYLHVQPKITNITTNYSSQSHSLILKGRAIGIEHLTLTYQGKKVRTVNVKSGQFKFAQQFKGYGDFKLMKGQQVLATIPSQQYATPKVKVTSAERTTKGIYYTLIGSRDATINIAQNGQVIKTIKTQVRLQKYLFQMQKSKIAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP8</accession>
    <name>F9USP8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional protein: transcriptional antiterminator, BglG family PTS system, EIIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642380.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890692.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3138"/>
    <dbReference type="EnsemblBacteria" id="CCC80178">
        <property type="protein sequence ID" value="CCC80178"/>
        <property type="gene ID" value="lp_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3138"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2626"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_1_0_9"/>
    <dbReference type="OMA" id="AYDRKNG"/>
    <dbReference type="PhylomeDB" id="F9USP8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2671-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="417"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="560"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="707" mass="80217" checksum="0B7ADFA1F275651A" modified="2011-10-19" version="1">MADKLTNQERRLLQVLAEGSHYLSTESLAASLQVSRRSVYNYLNNVSRKLISVGIEPPRNVNGSGYYLTRDSKLYVKDLINGKDGEPDKRVHRVQFTDRRNILLLALFVGERDITISQLMNITGVARNTVISDLSRVRKELGENRIELVGTKDGHSLRGQELTIRNYFQVHFTALIDGYDWVQKYQADNSFFAGKDTVGLNTMLNDWMHLVERQSERAFSDDAIRMIEFYYAFVLKRILSGCFIPQDTFPSNIDDRRELRNKKEFGLASNLLAQVGVEVGSHDSEALYLESLLLSGQLHSVEPDERDNVKTKVYKAAIEVVESFQQITGFSFYDRRQLTSELYVHLLSTYYRVKYHRQYRDGMVKAIEENYPDIYTYTELSIRPFEKLNNYPLNENELSLIAIYFGSQMYQDESHLGSALLVCSTGLGTSRMLKVQLESAFKGLKFVGPITKRNYNSLTQISESVVLSTIPLDKKNREVLVLHPIMNDREINELTKQLAVQGIVMPTLSPNKISALLDVISDNAKIINQTGLITGIKEVLSFSVKPYSKYERGYQPLLSELINKNTIQFATASHLDWQQAIALATLPLLSSGNVEQSYIDAMIRNVYSNGPYINIGDRIAFAHARPEEGVNKLGMALLCLDEPIELLDNQHRIQLIFVLAASNDRSHLKALAELASMLGDKNRLKQLLDARKVSEVESVIAEGEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR7</accession>
    <name>F9USR7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100875.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888162.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USR7"/>
    <dbReference type="EnsemblBacteria" id="CCC77648">
        <property type="protein sequence ID" value="CCC77648"/>
        <property type="gene ID" value="lp_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0085"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.70"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9USR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-70-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="444" mass="47745" checksum="C422E3F16B55588B" modified="2011-10-19" version="1">MNDLFEKAPIPKAYFHLAFPVVLGMVASMIYNLADTFFVAQTGNADLVAGIALGSPLFSFMLAVGDIFGLGGSAVISRVLGRHDYHQSARISSFCFYIAIALSLVLTALLLLFEHPILGLLGATAATRPYIADFYRILVLGSTFIIVSLVPGNIIRTEGLAQLSMIATISGTVLTIILDPLFLFGFHWGASGVAFANVLGYAVNTSLLVFFMRRAKTLSLAPKLAHISRPTLKAVVAVGIPASLTNLTQSFGMMILNSYLAAYGAQAVAAMGIVQKVYMVVMMVMVGFAFGAQPLVGYTYGAKNWQRLRATLRFDLKVEGGYATICAIILMIFAPQLIKLFMNQPVIVTMGTQMLRAMLITTPLVGFILVFTTVFQSVGAGLSALAMALSRQAILLGIAIVILAQFFGLTGIIWAQAVADVLTCLLGWLLYRHTFKDIQVPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS1</accession>
    <name>F9USS1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide ABC transporter,lipoprotein-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0092"/>
    <dbReference type="EnsemblBacteria" id="CCC77652">
        <property type="protein sequence ID" value="CCC77652"/>
        <property type="gene ID" value="lp_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="57026937"/>
    <dbReference type="KEGG" id="lpl:lp_0092"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.75"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="EPSVMNM"/>
    <dbReference type="PhylomeDB" id="F9USS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-74-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388133" evidence="3">
        <location>
            <begin position="29"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="82"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="547" mass="59846" checksum="C0D512F763CA8E17" modified="2011-10-19" version="1">MSLSGTHKLILTIGSVVIIGGIGFTVNAHSHPATTKQSQVINLSAGSEIMSLDPAKMTDSVSNSQVTQVDEGLYRLNSQSQPVNALATKTTVTNGGHTYIIQLRHDARWSNGNRVTAHDFVYSWRRTLDPKSKSEFTYVFTNIKNADAIAAGKKKPSTLGVKANGDYQLTITLSKPVAYFKKILAVSTFYPVNQPAVNKYGKKYGTSAATTVYNGPFTLTGWTGTNNTWTLKKNPAYYDHKLVKLHQINYQVIKSNTTAYNLYQSNKLDSVTLNGEQSVQNKNNQELKTLAGGQISFIQYNHHDHVAANRELRTALSLAINRSQLTNKVLENGSLPAKSFGVRNMAKNPKTGTDFVNDATVDGTVNYNLNQARAAYHKAQRQLGKKSLTLTITCGDDDNSHQVAEFIQGQLTSHLPGLKVTIKAMPFTAMLGKVSKGAFQLNLTSWSMDFADPSQSLTILTGDSNSNMGHYQSKAYDQAMQAADGPDALNATKRYQDLVQAAKTALTDQAVTPLYEGRSHLLVKSHLKGVIYNNFSGAANYRTAYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU7</accession>
    <name>F9USU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100895.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888192.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0125"/>
    <dbReference type="EnsemblBacteria" id="CCC77678">
        <property type="protein sequence ID" value="CCC77678"/>
        <property type="gene ID" value="lp_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0125"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.102"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_1_1_9"/>
    <dbReference type="OMA" id="PVGASAC"/>
    <dbReference type="PhylomeDB" id="F9USU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-100-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="27678" checksum="072B46B5AD57379E" modified="2011-10-19" version="1">MTDKLTLLQYDPNPTAMVGPDVDGRFTVPAKLLYIFSGDDYFQQFVTRYHGHRLGQFNTITKVSWVYQIGYRGQKLAVAQAPLGSPAATMYLEMLIDFGARTVIAVGSCGALTALPEEQLLIPTVALRDEGTSFHYLAAADWVPLDPKVIQVLGTTLTKACLPWQMVKTWTTDAFFRETVSKVKAARQQGCQVVEMECSALAACSAFRQVSFGQLLYTADTLAQLEHYDPRHWGAGGVLAAIELAVESLAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT01</accession>
    <name>F9UT01_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643686.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0190"/>
    <dbReference type="DNASU" id="1061441"/>
    <dbReference type="EnsemblBacteria" id="CCC77732">
        <property type="protein sequence ID" value="CCC77732"/>
        <property type="gene ID" value="lp_0190"/>
    </dbReference>
    <dbReference type="GeneID" id="57027019"/>
    <dbReference type="KEGG" id="lpl:lp_0190"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.157"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="HTGLGWD"/>
    <dbReference type="PhylomeDB" id="F9UT01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-154-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="32683" checksum="04C5AD6AA10A8037" modified="2011-10-19" version="1">MLAYGYQKFGGPTVFEELPQSQLIPTDNQLLIKTLAVNLTEEDRLERLGTIQSVALPHIPGHDVIGKIIQVGAAVTDLDVGTVVAARTNHTYADQVCLDSDLAVTMPTNLDPVTAVSLVTPGIVAYKTVRYFADIQADQTVIVKGAGSPVGLLIIQLAKRLGAHVIAIASDRYANLIATLGVDQFVDYQHQNPVHVLADRGDVVINVAIDGVGGKDDLAMAKFDATIASFARHLPATSKSIRFQAIQPTEVISDQAALQLLFKLLDTGQLTTTINEQLPFNLTGFIQGHQRLDEPHVGQVVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT02</accession>
    <name>F9UT02_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-related transport protein, NHAC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nha1</name>
        <name evidence="8" type="ordered locus">lp_0192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643687.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888247.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0192"/>
    <dbReference type="EnsemblBacteria" id="CCC77733">
        <property type="protein sequence ID" value="CCC77733"/>
        <property type="gene ID" value="lp_0192"/>
    </dbReference>
    <dbReference type="GeneID" id="57027020"/>
    <dbReference type="KEGG" id="lpl:lp_0192"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.158"/>
    <dbReference type="eggNOG" id="COG1757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033405_1_0_9"/>
    <dbReference type="OMA" id="NTCGAYQ"/>
    <dbReference type="PhylomeDB" id="F9UT02"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-155-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004770">
        <property type="entry name" value="Na/H_antiport_NhaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00931">
        <property type="entry name" value="antiport_nhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="162"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="466" mass="48978" checksum="435FDBF9AF8924C6" modified="2011-10-19" version="1">MPNSKKWRSVQLPEALLVLLIMLAIMGLGVIKFGLSPQTPVILVIALIILWARIRGAHWDDIHGGIIDGIKTGIIPIFIFLLIGALISVWIAAGIIPSMMVFGFHLISAQWFVPSVFLVCAIIGTSIGSAFTIISTIGIALFGIGTTMGINPALIAGAIISGAIFGDKTSPLSDSTNLAAAIAEADLFDHIRNLMWSTIPAFVVSLVLYAVLGAGAATQSHLGKIQTTLTVLNNNFTISWWAALPLVVMFACALLKIPAIATLLMNIGLAIVMIFIEQPHIALTKIATMIETGFVAKTGNAGVDALLSRGGISAMMSTVSLILLTLSLGGLLMKFNLIQTAMVPLTKRLKGAGATVTAAILAGIGVNIFVGEQYLSVILPGKAFKTTFNQRGLANLALSRVLEDGGTVINYLIPWGVAGAFAANTLGVSTLAYLPFCFFSLLSPVFSIISGFTGWGLKHQPANEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT14</accession>
    <name>F9UT14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641799.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77745">
        <property type="protein sequence ID" value="CCC77745"/>
        <property type="gene ID" value="lp_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="57027032"/>
    <dbReference type="GeneID" id="66448323"/>
    <dbReference type="KEGG" id="lpl:lp_0207"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.171"/>
    <dbReference type="eggNOG" id="ENOG5030A6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2700054_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-167-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="73" mass="8150" checksum="4C9A2E7BE9CD20A6" modified="2011-10-19" version="1">MEQLKPIEASLLQAYELNCVVRLTLSDGHQPSGLIAAVDDQQLFLNQQAGVVKPIALSDVTAIDFLKQSWWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT16</accession>
    <name>F9UT16_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, DUF814 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100918.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888261.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0209"/>
    <dbReference type="EnsemblBacteria" id="CCC77747">
        <property type="protein sequence ID" value="CCC77747"/>
        <property type="gene ID" value="lp_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0209"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076487_0_0_9"/>
    <dbReference type="OMA" id="ARDNDIW"/>
    <dbReference type="PhylomeDB" id="F9UT16"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-169-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="1">
        <location>
            <begin position="162"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="32261" checksum="3239C12472C7E1E2" modified="2011-10-19" version="1">MTTTTDVDLVQTGLAHLIHHTRKQIESLTKALDHLPDVSDLQLKGTLLKTYASQIEGHHHFVELPDYQGHQLSIKLDIKKSIIENAEDYFHHYHKSKRGQATVQQNLTTAKTELYQQLATQAAFDPNDPQAVAALKQTLIAAGAIHTHVLHSSKAPTPAHPRRFYTHDHVLVEVGKNSRQNDHLTLTARKDYYWMHAGGEIPGSHVVIHSNHPSEQTLQEAAVLTAYYSKGRQMNRVPVDVLTVGQMRKPKGAKAGLVTFSGPARTITVVPDATLAAELRDQEDIHHDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT48</accession>
    <name>F9UT48_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-dependent hydrolase, subgroup B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888293.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0250"/>
    <dbReference type="DNASU" id="1061211"/>
    <dbReference type="EnsemblBacteria" id="CCC77779">
        <property type="protein sequence ID" value="CCC77779"/>
        <property type="gene ID" value="lp_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0250"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.206"/>
    <dbReference type="eggNOG" id="COG3964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036699_1_0_9"/>
    <dbReference type="OMA" id="IGNNPPN"/>
    <dbReference type="PhylomeDB" id="F9UT48"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-201-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="PTHR42717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039004">
        <property type="entry name" value="ADE_EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03583">
        <property type="entry name" value="EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="4">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="372" mass="40226" checksum="C095A206A2F097D5" modified="2011-10-19" version="1">MTELYIHNGRDVSGAPVAVLITDGVIAEVGTELTVPVGCPTLDAQGCYITAGWIDDHTHCNAHAALYYDDADAIGYRTGVTTVIDAGSTGADNVADLYQQAHRAATNVYALLNIARTGIVAQDELADLNQLSFSALRTAIKRYPDFIVGLKVRVSKSVVGDNGVEPLRVAKQYQADLTVQLPLMVHIGSNPPELAAIIALMRPGDVLTHCFNGKPNGIVNSTGEVAQYVRKAYQKGLIFDVGHGTDSFSFRTAALARTAHLFPQTLSSDIYYRNRLNGPVYSLAVCVEKLLLLGYRLEEIIPMITTNPARIFKLTHKGQLCRGYDADLTIFQTVTAPQIVVDSTGEERIAPTQVIPTYSVIAGRVYTCGVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT73</accession>
    <name>F9UT73_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5 diketo-D-gluconic acid-like reductase (N-terminal), NADP dependent, (Promiscuous)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Sandbrink H.M."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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            <end position="76"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="8346" checksum="EAF84F0D0EE5B62E" modified="2011-10-19" version="1">MKKEITLNNGLKMPVLGFGVFQIPDFEECKQAVLTALKQGYRLIDTAAAYGNERAVGAAIRESGIAREEIFVTTKL</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890749.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3211"/>
    <dbReference type="EnsemblBacteria" id="CCC80235">
        <property type="protein sequence ID" value="CCC80235"/>
        <property type="gene ID" value="lp_3211"/>
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    <dbReference type="GeneID" id="57026498"/>
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    <dbReference type="PhylomeDB" id="F9UTB7"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0015424">
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <location>
            <begin position="2"/>
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    </feature>
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        <location>
            <begin position="34"/>
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        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="28125" checksum="C703D981588EE014" modified="2011-10-19" version="1">MIKLEHLNKTFGNHQALTDINTEFKEHQTTVIVGPSGSGKSTLLRSLNLLERPEQGLYHFNDETIDFTKPLTNKTILNIRRKTGMVFQGYNLFPHLSVVKNVMEGPVQVLKKDSATAKKSALELLARVGLQDKADAYPEQLSGGQQQRVAIARSLAMDPEFILLDEPTSALDPELEAGVLRVLLALAQEEDSMIIVTHNMEFARAVADKILFVEDGKILFDGTPAEFFKQPTQRIADFLAAMTFTTISDKANQ</sequence>
</entry>
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    <accession>F9UTI6</accession>
    <name>F9UTI6_LACPL</name>
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        <recommendedName>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
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        <property type="protein sequence ID" value="CCC80304.1"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="GeneID" id="66450832"/>
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        <property type="reaction ID" value="UER00155"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="19338" checksum="568DBE387CFF2543" modified="2011-10-19" version="1">MASREERVYLSVGSNIHPRVQNIQQALSRLRAVNGVNVIDESHWYETQPWGKRDQANFYNVSVSLTTNLTPEELLDELHTIEQAGHRQRLVHWGPRTIDLDIIFWGDRQINTATLTIPHAQAAKRNFVLLPTAEIAKTDVLVGPQVAQLIAANQDQSWIKKVRNVSELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR8</accession>
    <name>F9UTR8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100963.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888352.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77838">
        <property type="protein sequence ID" value="CCC77838"/>
        <property type="gene ID" value="lp_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0314"/>
    <dbReference type="eggNOG" id="ENOG502ZZ83">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465155_0_0_9"/>
    <dbReference type="OMA" id="VIANIKF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-260-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="110" mass="12355" checksum="E143B8102EDEF5B7" modified="2011-10-19" version="1">MGLTILYGHPLQLRHDKGAVKMTTKSIRTPIQPWFTLVVAGSLLITLFSTALWWLASSAFCALLILNLQFIVFPTTADRYWLNRLSLGLVLVLVVLANIKFLIISGLTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX0</accession>
    <name>F9UTX0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100981.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888404.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0373"/>
    <dbReference type="EnsemblBacteria" id="CCC77890">
        <property type="protein sequence ID" value="CCC77890"/>
        <property type="gene ID" value="lp_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0373"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.317"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268042_0_0_9"/>
    <dbReference type="OMA" id="YTENTGK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-312-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="5">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1231" mass="129768" checksum="7F22F9ED539FAA0F" modified="2011-10-19" version="1">MYTENTGKHHRNGLPVWLLPLLVVISFWGVSQNIMVVDASSSVTVLPGNGGTLPLVNQLVIKQNDTALQGITNNAGDRGSLTPKNGAQRVLIHKVKDSDTITSTYGTVGTFHGQEVTAKVTISHIKVHDDSHKAPSGMKQTDGAFQIGPGFSSDTTMSNVAQFNVSYEFYYADTHAAVNIQNAFITLSSLDGPVAGTSTGFEYTAYLGAGKIYTVENSIVKQIANPLGGGQLVMAGQTARDASWPYTSSTAATFGVSGTKLEFIYGTTRVNSGNSWLQPVYNVSTITLGTPAIATPTLSATQSATDKQNRTLTYDLQQKVNVLDQDLMTKYKDWSENITIPANAKYTKGEVVNDAGQALPSTAYQVSYDEKTHQVKWHLTDAGIKSLPFKGETYHFKAQVQFSDDVDDQTKVTATGQTAIDKQTKTSNTVTNTIDNQATITVHHYMTDSTDKVAPDETVKVGYGKAYDVTKQVKTITGYKRNATLDEHTRGTASKTTKEAVMYYDPLPYNIHVNYLLTDGQKLDELDVTGLYGDTYTTEATDFEDLYTVDTDRLPTNAQGTVTEKPTTVNYYYQPTTGQWVDVGNQSSVLVRQDTKHNVRSVSQIYANDSGFTVKYNQDAAQVAIAASDTNGTQDNSLVFDYNSKYTFELSKNETVTFKVDDQGQVTATRVLGAEQTVTTFDKSGQLKTVTTVTNANGTKSQQTNTVDGLKSMVTGEQYDLGLLNGLKVTAQKEINPSQAATTESKTTTDTSQSGSNQSTSTTATDQTETNESTAGSSTNATNASSSVDASSANSQGDTEATSQSGTSASADSKTDSSVASSTSQTTDGKTDGETTNTGDTTTGTTTDSGLGFKSPFTEDQNTSSALGSAQTSSSLNSDTSAAVQALIAEPNSTPVVLGEDASFEEGVPVNDPVFSNDEGVSPNNNPSSAATPLAQATNTRARLTQNGKLLYEGTLKADQGEQNLYVSPDTTVEVDGGDDGDGFYLDTYDGDKGMAYTLGSGYAWAAENNDVTAAPASSATTSSESAASESNTNSSDSSRTASSAVDHSTSSASTSDASQSSHSTSSGESSHPESSSGSSTTSDSADADKQAAARSSQTQSNSVNGSSQAVSSSTVTSQSSVPTKANTKQASSTPTTKANRATVAAATSSTAPRQSRATTASASVPSVTSASAVAASRDKQQSAFKKQHPILNQILPKTNSAVATWLVWLGVGLLLLTVAITMVIKKRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX2</accession>
    <name>F9UTX2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100983.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888406.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0375"/>
    <dbReference type="EnsemblBacteria" id="CCC77892">
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        <property type="gene ID" value="lp_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0375"/>
    <dbReference type="eggNOG" id="ENOG503463I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870883_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-314-MON"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="139" mass="16170" checksum="18EE2C931A5CDE17" modified="2011-10-19" version="1">MSNLKILKNWGDNNLLELSVSAESEFVTIRQMCYVQDTDLKKIGEKIIAYSFDFTEETYVEFGKKKGDFTPAFSLRFLPTDNSGHVEIEIDMEIDDNPDRKHRCKFYIYSELGLIEQFGRSLILLSENKNDDISLNIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888433.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0412"/>
    <dbReference type="EnsemblBacteria" id="CCC77919">
        <property type="protein sequence ID" value="CCC77919"/>
        <property type="gene ID" value="lp_0412"/>
    </dbReference>
    <dbReference type="GeneID" id="57024217"/>
    <dbReference type="KEGG" id="lpl:lp_0412"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.338"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_1119056_0_0_9"/>
    <dbReference type="OMA" id="RIWISAI"/>
    <dbReference type="PhylomeDB" id="F9UTZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-342-MON"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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            <begin position="6"/>
            <end position="28"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="58"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="91"/>
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        <location>
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            <end position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="154"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="27914" checksum="C5F6726BA2C12550" modified="2011-12-14" version="1">MKNNDIITKIAICFVLVPIVLIVLPYLISPIISEKYGQMTVDLIIFLVAIVLSQNIWHIKISFLSLKKPLSQLCQLIPSILFLLFTRFSTLSSMSFRLIDARIILTVLFIALAEESVYRGLLIPLSLVFTKNKQYTAIVISGVGFALAHLVNIVNSPWSIVMLQMLIVFASGLLWGTLYLKTNNLSLTIMLHFLDDLPLFLMKETSELVTPTRPQLISAIMAYLIVVGIIGIITFLQVEGLHLWKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU29</accession>
    <name>F9UU29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0444</name>
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    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888463.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0444"/>
    <dbReference type="EnsemblBacteria" id="CCC77949">
        <property type="protein sequence ID" value="CCC77949"/>
        <property type="gene ID" value="lp_0444"/>
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    <dbReference type="KEGG" id="lpl:lp_0444"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.364"/>
    <dbReference type="eggNOG" id="ENOG5030B6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768996_0_0_9"/>
    <dbReference type="OMA" id="CFASTIG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-370-MON"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="410" mass="46207" checksum="D9886D9FD82F6FCE" modified="2011-10-19" version="1">MLVAQLIRMIVTSFKTIVTLLRYNRRKHVTIIWMEGAKNVIKLVNQLEYISQSTGIPVTIGESVSTSTLSLSRSDQNNTVVVQGTILDKPVLFMSYGGQRDLRPLGLYARVSQVNRDPLVFIFPQLSANERHEYLKNRMPFMTSDGEMFLPFMGTRLLPEAVNDSPGIAGNPLASAAQRLALTIVLAQLIFERHPEKAKVCPELAAFRTTDDRFLIKSGQCFASTIGKQVSINNRVTFSRAVKPLVAHGWLKSIGETKERVYTCELDSRRFFDQIAPFLVSPVQSVDLVQLAKASVESASKNFLYSGLTGLSKVTMISDNRKQQTVIMDRSRRQTLRTTVDADTDERKVACEVQVSKYQLSGFNTLFRLIANYPKNVLDPFHLYVLFRNDMDERTQGEAEELVDQIWNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU58</accession>
    <name>F9UU58_LACPL</name>
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        <submittedName>
            <fullName evidence="8">Purine-cytosine transport protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="ordered locus">lp_3374</name>
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    <organism evidence="8 9">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890874.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3374"/>
    <dbReference type="EnsemblBacteria" id="CCC80360">
        <property type="protein sequence ID" value="CCC80360"/>
        <property type="gene ID" value="lp_3374"/>
    </dbReference>
    <dbReference type="GeneID" id="57026622"/>
    <dbReference type="KEGG" id="lpl:lp_3374"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2813"/>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048240_1_1_9"/>
    <dbReference type="OMA" id="ASWQIAF"/>
    <dbReference type="PhylomeDB" id="F9UU58"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2848-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="457" mass="49727" checksum="086A30706D021A6B" modified="2011-10-19" version="1">MQQESKYQIEVVAPKHRHMSNWDMFATWIGANANNGTWYVGGVLAACGLLTALKVIVASSTLSYLCLSLVGFMGYKTGAATMSLIRGSFGVRGSYVPSFVNLTQYIGWTAVNTFIAATSVSYLLHDLVGWPVYGKPGGAKGLILGIIVMSVLHLLSVSVGQRSVQMIERLGIILVILFVLWETVVVFQTVSVHDLLTWQAPTHLHMTAGAGMDTLAAFNLSWVTAGADFTRFTRKKSGATGMPFLGAFTGLFWFAFIGLAATISIAITSGTYDPNNSDPSTIASRLGLGVLALLVIVLTSMTANAVNLLAAGSALSNIFPRIRLRPALWAVTIIATLVTLIPLIMGSFLAAFTAFLDYIGMVLGPMISVMLVDYYWRHRQHYDINELASSKGQYWYHHGVNWIALLCWVLGVAIFLLLKHVVWIATVTGATFIDMALIGVIYVALMRIFYPLPAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB0</accession>
    <name>F9UUB0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102163.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890926.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3432"/>
    <dbReference type="DNASU" id="1063689"/>
    <dbReference type="EnsemblBacteria" id="CCC80412">
        <property type="protein sequence ID" value="CCC80412"/>
        <property type="gene ID" value="lp_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3432"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2860"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_9"/>
    <dbReference type="OMA" id="VIQDPTM"/>
    <dbReference type="PhylomeDB" id="F9UUB0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2900-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="231" mass="25418" checksum="E58745D6C23695B4" modified="2011-10-19" version="1">MDELTAFNQCLAWLTHTTALPEHLDGLVLCGNSLPATATAAGQLAQDYQLPLLIIAGGVGHATKYLRQNLNLPKSQASEAELMATLVRKTGYQGSIRLDKTSTNTGSNATHARALAPTDWRHVLLVQDPLLARRTTLTFSANWSNANFIRYAPATLQLNRLQPMQFTPNTIVAGWQPAYFTELLLGEFQRLVDTPTGYGPRGQGFIAHVDIPEEVLAAARYLQSQSLHRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB1</accession>
    <name>F9UUB1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase E-like protein, SGNH hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102164.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3433"/>
    <dbReference type="EnsemblBacteria" id="CCC80413">
        <property type="protein sequence ID" value="CCC80413"/>
        <property type="gene ID" value="lp_3433"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3433"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2861"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870942_0_0_9"/>
    <dbReference type="OMA" id="PLNRIAY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2901-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35774" checksum="5909B10E38DF4D04" modified="2011-10-19" version="1">MDYQITQANQPLMPAYFQGRWAVKQIADRDVMYSTNLGAEIDFQVTDASFVRLTFLPLAYELPSWVAIQIDGLPFQRQAVTNDPLWLTLDGRPHVVRVVLSGNTDEDRVWDGNQGFTVKALTTDGELQPVRLGRHSVTWIGDSLTAGCWVMGKNPAEDYRAEANYAAVASDLLNARNVRIAYSAVGLSKPGTGGVPVLPEVLTAVDSKTTWQPVPTDLVVINVGTNDRHTDDTTFTVVLRRFLNQVQTLYPNSRLAVMIPFNQNFASIIRAVVAEFMQLQLIETATWQLSTTDGVHLDLAGSRMAGELTAQALRTQYPDVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD0</accession>
    <name>F9UUD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102172.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890946.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3460"/>
    <dbReference type="EnsemblBacteria" id="CCC80432">
        <property type="protein sequence ID" value="CCC80432"/>
        <property type="gene ID" value="lp_3460"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3460"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2880"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035986_0_0_9"/>
    <dbReference type="OMA" id="PVFEYAN"/>
    <dbReference type="PhylomeDB" id="F9UUD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2920-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="3">
        <location>
            <begin position="32"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="2">
        <location>
            <begin position="311"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="445" mass="49540" checksum="87E12079A5FCF896" modified="2011-10-19" version="1">MINNANEYTRWQQAMLVTPTADTIQAGATMIDRAIIELLATDQFYGELLTRLPRQLNTTLTAPFILAWQNNQLVLQYAPTVIARAFSQFSYLQAGLKHVALHIVWQHPVRYRDQVKQQPELVTLATDLAVNQYVDGLPKDAVSLTTVQPLVDAQLPRRADSGCYLKLLQQQSRSQLQPNGAPTATSRNKDQRQPAKGSGDQKSQQLIDDPSGWSASEQLTNPNLATARLKQLAKDAWQQTNEAGRGLVAGNVRAQLTVMTQPAQLDWRQLLVRGLGQIPSGTKASHARFNRRQPARMEIPGQIGDTRLDLQVYVDNSGSISDLMLQRLLAQVATLTRLFAATITVKLFDAIVQPGQTYQVSLPQQIRFTRRGGGGTVYQSIFDDLLTHHKTNATTLALILTDGRGERHVESHRFTNVIWLLARAEDRLSIEPAIGHVVNLNLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD4</accession>
    <name>F9UUD4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ileT</name>
        <name evidence="9" type="ordered locus">lp_3466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643557.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890950.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3466"/>
    <dbReference type="EnsemblBacteria" id="CCC80436">
        <property type="protein sequence ID" value="CCC80436"/>
        <property type="gene ID" value="lp_3466"/>
    </dbReference>
    <dbReference type="GeneID" id="57026682"/>
    <dbReference type="KEGG" id="lpl:lp_3466"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2884"/>
    <dbReference type="eggNOG" id="COG1114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036807_0_1_9"/>
    <dbReference type="OMA" id="VWIATIG"/>
    <dbReference type="PhylomeDB" id="F9UUD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2924-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="463" mass="49598" checksum="F3EF0713FCA730C0" modified="2011-10-19" version="1">MLNRVQKRNLTKRDYVTLSSMIFALFFGAGNLIFPLHLGQLAGGHWGIAAAGFLITAVLLPLLSVLAVCVTKSKGVYDIGKPLGATFAVVFMVLIHFTIGPFFGTPRTATVSFTVGLAPFFPAKYQSLALLLFSAAFFGLAYYLSVEQSKIMARVGKLLNPLFLLLLVAIFAVAFSSPLAHAGSTSATAAYQTAGFTNGFLQGYNTMDALAGLALGVTIVTAVNFMGQTDPNKAAWVTARAGFFSMAFEGLIYVLLILLGAQSLGQFKLSDNGGVAFDQIVNHYMGNVGQAILAVLIITTCLTTAIGLVAAFAQDFHKHFDFLSYKAWLRITCLASFLTANVGLNQIIAWSTPVLMFLYPLAMALIFLSILSPLFHKSSVVYVWVVVFTVVPAVFDMVAAFPAVVSQSTFGQAMAHVQSFLPLASSGMDWLVPALVGAVFGTAHYLLLQRAKASTGMEVPMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH7</accession>
    <name>F9UUH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbg8</name>
        <name evidence="6" type="ordered locus">lp_3512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102196.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890993.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3512"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80479">
        <property type="protein sequence ID" value="CCC80479"/>
        <property type="gene ID" value="lp_3512"/>
    </dbReference>
    <dbReference type="GeneID" id="57026724"/>
    <dbReference type="KEGG" id="lpl:lp_3512"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2927"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="GIECANV"/>
    <dbReference type="PhylomeDB" id="F9UUH7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2967-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="486" mass="55874" checksum="D0757E76D7F3C6C2" modified="2011-10-19" version="1">MYKPTYPKTFPKDFLWGGATAANQVEGAWNEAGKGLTTAEVVKKTTDRKHMSMDDVTIFSIQTALDDQTDTMYPKRRGVDFYHHYKEDIKLFAEMGFKVYRFSIAWSRLFPKGDELKPNSDGLAFYDRVIDELRRYHIQPLVTLSHYEMPIGLTLKQNGWASRATIADFNRFTEVVFKHFKGRVPYYLTFNEINTGTWGFHATGAVDTENSAHDQMQLRYQALHHQFIASALATKQLHAIDPDAKIGSMLARMQTYPATPNPADVQAAQVEDDKNLFFTDVQARGEYPEFMNRFFAENDIQLQMAPDDQTILAKYPVDFISFSYYMTTVTQADAPEQVNGNMATGGRNPYLEESDWGWQIDPVGLRVTLNEMWDRYRKPLFVVENGLGALDQLTTDQQVHDTYRIDYLRKHIAQMKAAVQDGVQLMGYTMWGPIDLISFSTSEMSKRYGFIYVDQDDAGKGSLKRYKKDSFYWYQKVIKSNGEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUJ4</accession>
    <name>F9UUJ4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102207.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3531"/>
    <dbReference type="EnsemblBacteria" id="CCC80496">
        <property type="protein sequence ID" value="CCC80496"/>
        <property type="gene ID" value="lp_3531"/>
    </dbReference>
    <dbReference type="GeneID" id="57026732"/>
    <dbReference type="KEGG" id="lpl:lp_3531"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2944"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="OMA" id="NDRCATG"/>
    <dbReference type="PhylomeDB" id="F9UUJ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2984-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="325" mass="35006" checksum="E0F6A0508B524FC6" modified="2011-10-19" version="1">MKPTIKDIAAKTGFSIATVSRVLAKKQGTYSDKTQERILKVAKDLGYRKNTLAMELVKKKTDVIAVIVNVTPTNFSSGIIDGIQQRATEIGLQVIILYAGNRNTELQHQAIVTALERTVSGILLMAIEPDKADLQLLTESKTPFCFVSINLADERVKSVSSDNYQAAYLATKYLISHGHRTIGLAGIDHYHTGSQRLAGYQAALKDYSIHGQAEWVQPGDYSYQAGYNVFNAYQELGITGVVAASDMTAAGLQKAAQESNVKLPGALSVVSIDGTLICDIATPALTSVTQNFVQIGIESVNCLVGKSATRLVPVTLVERESVATI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O08318</accession>
    <accession>F9UL03</accession>
    <name>ARGC2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase 2</fullName>
            <shortName evidence="1">AGPR 2</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase 2</fullName>
            <shortName evidence="1">NAGSA dehydrogenase 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC2</name>
        <name type="synonym">argC</name>
        <name type="ordered locus">lp_0528</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="2697" last="2706">
            <title>Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed.</title>
            <authorList>
                <person name="Bringel F."/>
                <person name="Frey L."/>
                <person name="Boivin S."/>
                <person name="Hubert J.-C."/>
            </authorList>
            <dbReference type="PubMed" id="9098069"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="X99978">
        <property type="protein sequence ID" value="CAA68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888532.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="AlphaFoldDB" id="O08318"/>
    <dbReference type="SMR" id="O08318"/>
    <dbReference type="STRING" id="220668.lp_0528"/>
    <dbReference type="EnsemblBacteria" id="CCC78018">
        <property type="protein sequence ID" value="CCC78018"/>
        <property type="gene ID" value="lp_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0528"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.436"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_9"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="PhylomeDB" id="O08318"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-439-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
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        <property type="entry name" value="AGPR_type-1"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000112413" description="N-acetyl-gamma-glutamyl-phosphate reductase 2">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68239." evidence="2" ref="1">
        <original>S</original>
        <variation>P</variation>
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA68239." evidence="2" ref="1">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="341" mass="36940" checksum="CD35D297041CC42A" modified="2003-03-25" version="2">MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFDATAIMRDNAIVFFATSAGITRQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQQQLVEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMTTIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQNFNRYFDFAVTAGLPTLPVFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>P56512</accession>
    <accession>F9UL11</accession>
    <accession>P26299</accession>
    <accession>Q8GMW6</accession>
    <name>LDH1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase 1</fullName>
            <shortName evidence="1">L-LDH 1</shortName>
            <ecNumber evidence="1">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ldh1</name>
        <name type="synonym">l-ldhL</name>
        <name type="synonym">ldh</name>
        <name type="synonym">ldhL</name>
        <name type="synonym">ldhL1</name>
        <name type="ordered locus">lp_0537</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Bacteriol." volume="176" first="596" last="601">
            <title>Lactobacillus plantarum ldhL gene: overexpression and deletion.</title>
            <authorList>
                <person name="Ferain T."/>
                <person name="Garmyn D."/>
                <person name="Bernard N."/>
                <person name="Hols P."/>
                <person name="Delcour J."/>
            </authorList>
            <dbReference type="PubMed" id="8300514"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>DG301</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2004-04" db="EMBL/GenBank/DDBJ databases">
            <title>Expression of Derf 7 gene in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Tsutsui M."/>
                <person name="Yamashita M."/>
                <person name="Murooka Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>L137</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2002-09" db="EMBL/GenBank/DDBJ databases">
            <title>Expression of LDH gene in Candida kefyr isolated from Mongolian Koumiss.</title>
            <authorList>
                <person name="Ham J."/>
                <person name="Kim H."/>
                <person name="Kim H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-320</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="BAD16691" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="1"/>
    <dbReference type="EMBL" id="X70926">
        <property type="protein sequence ID" value="CAA50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB177763">
        <property type="protein sequence ID" value="BAD16691.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF548372">
        <property type="protein sequence ID" value="AAN40797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A36957">
        <property type="entry name" value="A36957"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642078.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888540.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P56512"/>
    <dbReference type="SMR" id="P56512"/>
    <dbReference type="STRING" id="220668.lp_0537"/>
    <dbReference type="EnsemblBacteria" id="CCC78026">
        <property type="protein sequence ID" value="CCC78026"/>
        <property type="gene ID" value="lp_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="57024312"/>
    <dbReference type="GeneID" id="66448588"/>
    <dbReference type="KEGG" id="lpl:lp_0537"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.444"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_9"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="PhylomeDB" id="P56512"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-447-MON"/>
    <dbReference type="BRENDA" id="1.1.1.27">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="P56512"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000168357" description="L-lactate dehydrogenase 1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA50277." evidence="2" ref="1">
        <original>D</original>
        <variation>H</variation>
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; BAD16691." evidence="2" ref="2">
        <original>K</original>
        <variation>Q</variation>
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA50277." evidence="2" ref="1">
        <original>S</original>
        <variation>C</variation>
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="320" mass="34206" checksum="34B8A5FD12A64EBC" modified="2003-03-25" version="2">MSSMPNHQKVVLVGDGAVGSSYAFAMAQQGIAEEFVIVDVVKDRTKGDALDLEDAQAFTAPKKIYSGEYSDCKDADLVVITAGAPQKPGESRLDLVNKNLNILSSIVKPVVDSGFDGIFLVAANPVDILTYATWKFSGFPKDRVIGSGTSLDSSRLRVALGKQFNVDPRSVDAYIMGEHGDSEFAAYSTATIGTRPVRDVAKEQGVSDEDLAKLEDGVRNKAYDIINLKGATFYGIGTALMRISKAILRDENAVLPVGAYMDGQYGLNDIYIGTPAVIGGTGLKQIIESPLSADELKKMQDSAATLKKVLNDGLAELENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD9</accession>
    <name>Q6LWD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nickase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">traA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222044.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133752.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723588"/>
    <dbReference type="EnsemblBacteria" id="CAG17869">
        <property type="protein sequence ID" value="CAG17869"/>
        <property type="gene ID" value="CAG17869"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17869"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3115"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025383_7_1_9"/>
    <dbReference type="OMA" id="EKHTISH"/>
    <dbReference type="PhylomeDB" id="Q6LWD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3169-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040834">
        <property type="entry name" value="NES_C_h"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18208">
        <property type="entry name" value="NES_C_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NES_C_h" evidence="5">
        <location>
            <begin position="276"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="686" mass="80036" checksum="676BC88A48783ECE" modified="2004-07-05" version="1">MAIFHMSFQNISAGKGRSAIAGAAYRSGEKLFDQKEGRSYFYARSVMPESFILTPKNAPKWASDREKLWNEVEKKDRKSNSRYAKEFNVALPIELSTDEQKELLTKYVQENFVDQGMVADVAIHREHPDNPHAHVMLTNRPFNPDGTWGLKAKTQYIKDENGKQLLTKSGFPKQRKIWLVDWDKKEKINEWRHNWATSVNQSLAQKNIPDRISEKSFVDQGIQETPTQHEGINSQRQNRKAFNQQVRAQRSTQAKYHNINEKIRNHEHFDALTDELSFSEKHTISHLSQQLKTYVDLEHLDDKQCMLFNWKNSLLIKHAIGEDVTKKLLTIDQQTTSLAQANQLLNKVVDRATKKLYPELDFERTTAAERRELIKETNSEQTIFKDSELTERLADIRNDLLTQQLLTFTKRPYVSWKLVNQQAQTIEKQLTAVLAKHGHQLDDLKHTDRGILAAYEPNELEFISKAVKDLRVIREVKSVVQTQYDSILTTAFPDSDLDKLEPIDKEQIYTAVVYYDPELKPLSASDLSQLQQQPPVVFTSQQHQAGLNYLLGKMELKDIQDHRLQRVLKHDGTRQLFIGECGQDPKLDHKQIEMVQARLKQQTTRFDQYKQDQIKDYQAINYYPTSPKNYLTNILDEALITILYAKNTDYLRKQQLRGLKETEWEMTKKQRQHQTRNRHEDGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWE9</accession>
    <name>Q6LWE9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">orf28</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222035.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133742.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723578"/>
    <dbReference type="DNASU" id="3125615"/>
    <dbReference type="EnsemblBacteria" id="CAG17859">
        <property type="protein sequence ID" value="CAG17859"/>
        <property type="gene ID" value="CAG17859"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17859"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3106"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157175_0_0_9"/>
    <dbReference type="OMA" id="YVNHVEK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3159-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004276373" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="14210" checksum="5679AD8B8DB7A3CD" modified="2004-07-05" version="1">MTLIKRVGKALAVIVVVLAVSGFASHQYVNHVEKQRPIVTLAKHPKKVLFFYRDDCPDCQAIFHRIYWHNVISHNVVFINMNQTQNRHYIQQYQLTSVPTLIHGKQRYTGTNQQRIKQIVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q877N1</accession>
    <name>Q877N1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ISP1_10</name>
        <name evidence="4" type="synonym">ISP1_1</name>
        <name evidence="5" type="synonym">ISP1_2</name>
        <name evidence="6" type="synonym">ISP1_3</name>
        <name evidence="7" type="synonym">ISP1_4</name>
        <name evidence="8" type="synonym">ISP1_7</name>
        <name evidence="9" type="synonym">ISP1_8</name>
        <name evidence="10" type="synonym">ISP1_9</name>
        <name evidence="4" type="ordered locus">lp_1064</name>
        <name evidence="5" type="ordered locus">lp_1288</name>
        <name evidence="6" type="ordered locus">lp_1463</name>
        <name evidence="7" type="ordered locus">lp_1537</name>
        <name evidence="8" type="ordered locus">lp_2164</name>
        <name evidence="9" type="ordered locus">lp_2617</name>
        <name evidence="10" type="ordered locus">lp_3036</name>
        <name evidence="11" type="ordered locus">lp_3308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="11">WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="11">WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101247.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889307.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889375.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890606.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890824.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1064"/>
    <dbReference type="EnsemblBacteria" id="CCC78472">
        <property type="protein sequence ID" value="CCC78472"/>
        <property type="gene ID" value="lp_1064"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78657">
        <property type="protein sequence ID" value="CCC78657"/>
        <property type="gene ID" value="lp_1288"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78793">
        <property type="protein sequence ID" value="CCC78793"/>
        <property type="gene ID" value="lp_1463"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78861">
        <property type="protein sequence ID" value="CCC78861"/>
        <property type="gene ID" value="lp_1537"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79390">
        <property type="protein sequence ID" value="CCC79390"/>
        <property type="gene ID" value="lp_2164"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79760">
        <property type="protein sequence ID" value="CCC79760"/>
        <property type="gene ID" value="lp_2617"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80092">
        <property type="protein sequence ID" value="CCC80092"/>
        <property type="gene ID" value="lp_3036"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80310">
        <property type="protein sequence ID" value="CCC80310"/>
        <property type="gene ID" value="lp_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1064"/>
    <dbReference type="KEGG" id="lpl:lp_1288"/>
    <dbReference type="KEGG" id="lpl:lp_1463"/>
    <dbReference type="KEGG" id="lpl:lp_1537"/>
    <dbReference type="KEGG" id="lpl:lp_2164"/>
    <dbReference type="KEGG" id="lpl:lp_2617"/>
    <dbReference type="KEGG" id="lpl:lp_3036"/>
    <dbReference type="KEGG" id="lpl:lp_3308"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1089"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_1_0_9"/>
    <dbReference type="OMA" id="CKNCELY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1115-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1254-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1322-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1851-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2251-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2585-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2798-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-915-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="157"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="420" mass="48886" checksum="B02B30BE74DC71C8" modified="2003-06-01" version="1">MSQDHSTKVLLQIKDPNITDLVVQEATNGSLQVLAKLTYPVTVCARCGKRSMVKNGFKTVHIRIPRISERVTILNLKKQRFICKNCGKSSLTTTTLVKKHHQISENSLHAIDLSLTEDRTMASIAAQYNVSTNTISRRIKLLGQGTQPAFNGLPTMLCIDEFRSTDKQMSFIAVDAQTHDIITILPGRKNADIKDFFLNHYSKRHRDRVTRVVMDFNSQYQPAIRTLFPHAKLVADNFHLVQMALRSLNQTRVQLMKRFNPKSREYRVLKYYWRLYLKDYDSLEKRKPQWFAHLKDRMTQEQLVVAGLNLDQQFRQTYQAAHALVKAFQKRDYRSFKAALGHVENISPQLMTNIKSFIKNRQLIKNMTTGRLSNGPVEGVNRKIKQIKRTAYGYKNWQNFIYRIQIEFKIKIEKKSPIRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UI4</accession>
    <accession>F9UR31</accession>
    <name>G6PI_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">lp_2502</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890184.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UI4"/>
    <dbReference type="SMR" id="Q88UI4"/>
    <dbReference type="STRING" id="220668.lp_2502"/>
    <dbReference type="EnsemblBacteria" id="CCC79670">
        <property type="protein sequence ID" value="CCC79670"/>
        <property type="gene ID" value="lp_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2502"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2107"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037303_0_1_9"/>
    <dbReference type="OMA" id="NNIGEDY"/>
    <dbReference type="PhylomeDB" id="Q88UI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2162-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180659" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <sequence length="450" mass="49847" checksum="99DFCC7CF7A3E5D1" modified="2003-05-23" version="1">MAHISFDSSNLTKFVHNNELGEMQAMVTAADKELREGTGAGNDFRGWLNLPTDYDKEEFARIKTAAKKIQDDSDVLVVIGIGGSYLGARAAIEFLHETFWSSLSREDRKFPQVVFAGNSISSSYVNDLIHLIGDRDFSVNIISKSGTTTEPSIAFRVFKERLIAKYGEEAAKGRIYATTDRKRGALKQEADAEGYETFVIPDDVGGRFTVLTPVGLLPIAVSGGDIDSLMKGAADAQNEYKDADLSKNEAYQYAAYRNILYRKGYTTEILENYEPNMAMFSEWWKQLMGESEGKDQKGIYPSSANFTTDLHSLGQYIQEGRRNLMETVVKVDNATSDVDIPKETENLDGLKYLEGKTMAQVNTKAFEGVIMAHVDGGVPNMVVNIPSQDAYTLGYTMYFFEAAVAISGYLNGINPFNQPGVEAYKNNMFALLGKPGYEELTKKLTARLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V13</accession>
    <accession>F9UQJ3</accession>
    <name>YQGF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2274</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641524.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V13"/>
    <dbReference type="SMR" id="Q88V13"/>
    <dbReference type="STRING" id="220668.lp_2274"/>
    <dbReference type="EnsemblBacteria" id="CCC79482">
        <property type="protein sequence ID" value="CCC79482"/>
        <property type="gene ID" value="lp_2274"/>
    </dbReference>
    <dbReference type="GeneID" id="57025819"/>
    <dbReference type="KEGG" id="lpl:lp_2274"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1925"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_0_9"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="PhylomeDB" id="Q88V13"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1967-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000172079" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="144" mass="16023" checksum="F37436C7CC093F52" modified="2003-06-16" version="1">MKLMGLDVGSRTVGVAISDAFGWTAQGVEIIRINEDAEEFGIDRVAELVEELDAGGFVLGLPKNMNNTLGPRAEAAQHYGELLTARFHLPVDFEDERLTTVEAERMLVEEANTSRKKRKKVIDKLAASLILQNYLDRHGKLTQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VI6</accession>
    <accession>F9UQ18</accession>
    <name>LEXA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LexA repressor</fullName>
            <ecNumber evidence="1">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lexA</name>
        <name type="ordered locus">lp_2063</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640747.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889821.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VI6"/>
    <dbReference type="SMR" id="Q88VI6"/>
    <dbReference type="STRING" id="220668.lp_2063"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="CCC79307">
        <property type="protein sequence ID" value="CCC79307"/>
        <property type="gene ID" value="lp_2063"/>
    </dbReference>
    <dbReference type="GeneID" id="57025613"/>
    <dbReference type="GeneID" id="66449840"/>
    <dbReference type="KEGG" id="lpl:lp_2063"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1748"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_1_9"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="PhylomeDB" id="Q88VI6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1768-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000170047" description="LexA repressor">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <sequence length="210" mass="23302" checksum="65333D71E78449A9" modified="2003-06-01" version="1">MSKTSESKQMAVLRFIYERVNEKGYPPTVREIGEAVDLSSTSTVHGHISRLEKKGYIQKDPTKPRAIEVTPAGFEALGVETTPHQIPVLGTVTAGQPILAVQEATDYFPIPKELESFGGDLFMLTIRGESMINIGIMNGDQVIVRRQSSADNGDIIIAMTDENEATCKRFFKEADHYRLQPENDTMAPIILNNVSVLGKVVGLYRDMLFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VK1</accession>
    <accession>F9UQ03</accession>
    <name>SYP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">lp_2048</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640732.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889806.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VK1"/>
    <dbReference type="SMR" id="Q88VK1"/>
    <dbReference type="STRING" id="220668.lp_2048"/>
    <dbReference type="EnsemblBacteria" id="CCC79292">
        <property type="protein sequence ID" value="CCC79292"/>
        <property type="gene ID" value="lp_2048"/>
    </dbReference>
    <dbReference type="GeneID" id="57025598"/>
    <dbReference type="KEGG" id="lpl:lp_2048"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1733"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_9"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="PhylomeDB" id="Q88VK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1753-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248707" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="569" mass="63516" checksum="E50F4E653331CC1D" modified="2003-06-01" version="1">MKQSKLLIPTLKEVPNDAEALSHQMMLRAGYIRQISAGMYAYLPLAYRVLTNIEKIIRQEMEKIDAAEMLVPAVIPAELWKATGRYETYGPELFKLKNRHDREFILGPTHEETFTSIVRDEIKSYKRLPLTLYQIQAKYRDEDRPRYGLLRGREFIMKDAYSFHADEASLDDTFQDMAQAYQNIFERVGLKFRSIIGDGGAMGGKDSREYSAIAPVGEDTIVYSDASDYAANLEMARSLYVPKKSHASLKDMEKIDTPGVGTIDELAEFLKVGADQLVKSILFIADDQPVMALVRGDHEVNDVKLKNYLGADFLEMATPEQAQQYLGASFGSLGPVNVHDDVKIVADQYVKDMVNITVGANEDGHHFTNVNPERDFHAEAYVDIRFVQEGELSPDGAGVLKFTKGIEIGHIFKLGTRYSKDLHAEVLDANGRNIPVIMGCYGIGVSRLLSAIAEQRADENGLIWPKAIAPFDVHVIPVNPKKADQVEVADQVEAQLEAAGYNVLYDDRKERPGVKFADSDLMGIPARITIGKKASEGIVEIKLRQTGETLEVKQEEIANNLAVLLKNID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VL9</accession>
    <accession>F9UPY5</accession>
    <name>GRPE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">lp_2028</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101637.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889788.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VL9"/>
    <dbReference type="SMR" id="Q88VL9"/>
    <dbReference type="STRING" id="220668.lp_2028"/>
    <dbReference type="DNASU" id="1062226"/>
    <dbReference type="EnsemblBacteria" id="CCC79274">
        <property type="protein sequence ID" value="CCC79274"/>
        <property type="gene ID" value="lp_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2028"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1713"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_6_3_9"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="PhylomeDB" id="Q88VL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1735-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113801" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="199" mass="21443" checksum="C16481F8333BD9EC" modified="2003-06-01" version="1">MAKKSTRTTPEDSQASTTDSAATSTASEATQAATSATDDQAEQTTAVDPTQQITDLKAQLDAKDDQLLRAQAEIVNMQNRNKKEQAALLKYDGQALAKDVLPVLDNLERALATPADDEAAQQLKKGVEMVYGHLQDALKKHGVTEVAAAGEKFDPNIHQAVQTVPVDDDHPADTVVQVLQRGYLLKDRTLRPAMVVVAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VR4</accession>
    <accession>F9UPT8</accession>
    <name>PDRP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="1">PPDK regulatory protein</shortName>
            <ecNumber evidence="1">2.7.11.32</ecNumber>
            <ecNumber evidence="1">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1974</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="1"/>
    <dbReference type="EC" id="2.7.4.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889741.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VR4"/>
    <dbReference type="SMR" id="Q88VR4"/>
    <dbReference type="STRING" id="220668.lp_1974"/>
    <dbReference type="EnsemblBacteria" id="CCC79227">
        <property type="protein sequence ID" value="CCC79227"/>
        <property type="gene ID" value="lp_1974"/>
    </dbReference>
    <dbReference type="GeneID" id="57025552"/>
    <dbReference type="KEGG" id="lpl:lp_1974"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1667"/>
    <dbReference type="eggNOG" id="COG1806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046206_2_1_9"/>
    <dbReference type="OMA" id="YAQCEFE"/>
    <dbReference type="PhylomeDB" id="Q88VR4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1691-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000196667" description="Putative pyruvate, phosphate dikinase regulatory protein">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <sequence length="272" mass="30551" checksum="BC1C95068379BF6F" modified="2003-06-01" version="1">MSAIKVFILSDSIGETAHNVALAAAAQFSDYDIRYQRFPFVRTDSLLQTVLSQALKEHAAIFHTFVDRRLSQIVNQFCEAHELPYYDVITPALDTFSQITHVQPSNHPGTVHALNTNYFDRINAIEFAVTYDDGKNPSGFLEADVVLLGVSRTSKTPLSLYLANRNLKVANLPLVPQAQIPDEIWKVDPKKIFGLTNDPEKLNDIRRQRMVQYGLNPDTMYSNTDKIKAELEYADKIFKKIGCLVINVANKSIEETATLITESLNTDDTNNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VW2</accession>
    <accession>F9UPP2</accession>
    <name>ENO2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase 2</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno2</name>
        <name type="synonym">enoA2</name>
        <name type="synonym">enoB</name>
        <name type="ordered locus">lp_1920</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101591.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VW2"/>
    <dbReference type="SMR" id="Q88VW2"/>
    <dbReference type="STRING" id="220668.lp_1920"/>
    <dbReference type="EnsemblBacteria" id="CCC79181">
        <property type="protein sequence ID" value="CCC79181"/>
        <property type="gene ID" value="lp_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1920"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1618"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_9"/>
    <dbReference type="OMA" id="KHADNGI"/>
    <dbReference type="PhylomeDB" id="Q88VW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1643-MON"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133907" description="Enolase 2">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="429" mass="46621" checksum="A4548B6533D0AA05" modified="2003-06-01" version="1">MEKQVIETVKAREIFDSRGNPTVEADVILSDGTLGRAEVPSGASTGEKEAVELRDGGDRLAGKGVLKAVNNVNTVINHALHGADPFNQAHIDQIMIDLDGTPNKARLGANAILGVSMATARAAANALQQPLYRYLGGTDLELPQTFHNVINGGEHADNGIDIQEFMITPVERTSFRDGFEKIVNTYHTLKKVIEDAGYTSGLGDEGGFAPDLKNSEEALQMLHDAIIKAGYTPGKEIAIAFDAAASYFYNRTTHNYDFEGKTYTPAALGDYYLQLLAKFPEIVSIEDPYGEEDWDNFASFTAAHGDQLQIVADDPVCTNPQLIRQAIQRGMANNILIKLNQIGTVTETLAAIRLARKNGYATMMSHRSGETGDTFVADFTVATNAAQLKAGAPARSERVEKYNQLLRIEEELGADGARLAHFPNNVMFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VY8</accession>
    <accession>F9UPL7</accession>
    <name>SCPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">scpB</name>
        <name type="ordered locus">lp_1889</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ScpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889670.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VY8"/>
    <dbReference type="SMR" id="Q88VY8"/>
    <dbReference type="STRING" id="220668.lp_1889"/>
    <dbReference type="EnsemblBacteria" id="CCC79156">
        <property type="protein sequence ID" value="CCC79156"/>
        <property type="gene ID" value="lp_1889"/>
    </dbReference>
    <dbReference type="GeneID" id="57025482"/>
    <dbReference type="KEGG" id="lpl:lp_1889"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1592"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_9"/>
    <dbReference type="OMA" id="DGWRFYT"/>
    <dbReference type="PhylomeDB" id="Q88VY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1618-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211134" description="Segregation and condensation protein B">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01804"/>
        </source>
    </evidence>
    <sequence length="199" mass="21792" checksum="608A65F69E942FAD" modified="2003-06-01" version="1">MTNIEQIEGLLFVAGDEGITVAEIEHATGFAKPAITTMLTQLATKYQADPDSALMILSTANTYRLATKAAVAPVLKRYFEAPLTTSLSQASLEVLAIIAYRQPLTRIEIDEIRGVHSGSTIQKLVLRQLVTETGRLSEPGRPILYGTTELFLDYFGLKSLDDLPAIDLAALSDAEHPAPETDLFLNAFQDKLQAEREDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WN5</accession>
    <accession>F9UNW7</accession>
    <name>RL21_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">lp_1592</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640343.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889420.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WN5"/>
    <dbReference type="SMR" id="Q88WN5"/>
    <dbReference type="STRING" id="220668.lp_1592"/>
    <dbReference type="EnsemblBacteria" id="CCC78906">
        <property type="protein sequence ID" value="CCC78906"/>
        <property type="gene ID" value="lp_1592"/>
    </dbReference>
    <dbReference type="GeneID" id="57025176"/>
    <dbReference type="GeneID" id="66449476"/>
    <dbReference type="KEGG" id="lpl:lp_1592"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1341"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_9"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="PhylomeDB" id="Q88WN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1368-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000270678" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="102" mass="11049" checksum="EADBD97AEF0B6958" modified="2003-06-01" version="1">MYAIIVTGGKQYKVEAGQAIYVEKLDAAAGDKVTFDQVVFVGGDTTKVGTPTVDGATVEGTVEKQGRDRKVVTFKYKAKKGQHTKKGHRQPYTKVTIDTINA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X33</accession>
    <accession>F9UNG5</accession>
    <name>Y1415_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0342 protein lp_1415</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1415</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0342 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101395.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X33"/>
    <dbReference type="SMR" id="Q88X33"/>
    <dbReference type="STRING" id="220668.lp_1415"/>
    <dbReference type="EnsemblBacteria" id="CCC78754">
        <property type="protein sequence ID" value="CCC78754"/>
        <property type="gene ID" value="lp_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1415"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1186"/>
    <dbReference type="eggNOG" id="COG3679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140243_3_1_9"/>
    <dbReference type="OMA" id="YDNANEM"/>
    <dbReference type="PhylomeDB" id="Q88X33"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1215-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01526">
        <property type="entry name" value="UPF0342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000109978" description="UPF0342 protein lp_1415">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01526"/>
        </source>
    </evidence>
    <sequence length="114" mass="13217" checksum="E50853D3850FC81A" modified="2003-06-01" version="1">MAVNIYDTANQLEQELRQTKEFKELKVAYDTMKTNDSAFSLFKDFQEVQMQLSQKQMNGEELTDDEVQKAHDLADKVGNVDEIKSLMGKERNLNQLMNDLNQIITKPVQALYQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q88X65</accession>
    <accession>F9UND3</accession>
    <name>Y1373_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0344 protein lp_1373</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1373</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0344 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645248.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88X65"/>
    <dbReference type="STRING" id="220668.lp_1373"/>
    <dbReference type="EnsemblBacteria" id="CCC78722">
        <property type="protein sequence ID" value="CCC78722"/>
        <property type="gene ID" value="lp_1373"/>
    </dbReference>
    <dbReference type="GeneID" id="57025019"/>
    <dbReference type="KEGG" id="lpl:lp_1373"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1153"/>
    <dbReference type="eggNOG" id="ENOG5030A1X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146641_0_1_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1182-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01536">
        <property type="entry name" value="UPF0344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010899">
        <property type="entry name" value="UPF0344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07457">
        <property type="entry name" value="DUF1516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000105888" description="UPF0344 protein lp_1373">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01536"/>
        </source>
    </evidence>
    <sequence length="119" mass="13028" checksum="E346E312AAA98F72" modified="2005-05-10" version="2">MYLLGHIIGWLWLMLTVAIGLSRHSVKSANRFLILSRIGYLLIIITGVALAIRTLSGNWWLTLLKVILGLGTIGLIEVAFARKQESHLNSGLVTLLVCGTLLTIICGIGLHWQLTGNLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX5</accession>
    <accession>F9UML6</accession>
    <name>RL24_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">lp_1046</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX5"/>
    <dbReference type="SMR" id="Q88XX5"/>
    <dbReference type="STRING" id="220668.lp_1046"/>
    <dbReference type="EnsemblBacteria" id="CCC78455">
        <property type="protein sequence ID" value="CCC78455"/>
        <property type="gene ID" value="lp_1046"/>
    </dbReference>
    <dbReference type="GeneID" id="57024702"/>
    <dbReference type="GeneID" id="66448958"/>
    <dbReference type="KEGG" id="lpl:lp_1046"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.882"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_2_9"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="PhylomeDB" id="Q88XX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-898-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130668" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="103" mass="11380" checksum="79DF3AD224144D63" modified="2003-06-01" version="1">MLIKTGDKVRVISGKDRGQEGTVKKVISAKNRIVVEGVNKIKKHQKPTNVNPQGGIVDIEAPIDASNVMYLDPSTNEPTRLGVRREDGKRVRYAKKSGKDLEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YP6</accession>
    <accession>F9ULT8</accession>
    <name>KTHY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmk</name>
        <name type="ordered locus">lp_0703</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101140.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888691.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YP6"/>
    <dbReference type="SMR" id="Q88YP6"/>
    <dbReference type="STRING" id="220668.lp_0703"/>
    <dbReference type="PRIDE" id="Q88YP6"/>
    <dbReference type="EnsemblBacteria" id="CCC78177">
        <property type="protein sequence ID" value="CCC78177"/>
        <property type="gene ID" value="lp_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0703"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.590"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_9"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="PhylomeDB" id="Q88YP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-612-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155289" description="Thymidylate kinase">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <sequence length="221" mass="24314" checksum="C18351577FD252A3" modified="2003-06-01" version="1">MLTGKLVTFEGPDGAGKTSALNAIVAKLQPQLGDRLVVTREPGGNQISEAIRKIILDRHNTAMDDRTEALLYAAARRQHIVQTIQPALQNDQLVLCDRYIDSSVAYQGAGRGIGEQAVYDMNQFATAGLTADLTLYFDVDAAVGLNRIQQHRQNEINRLDVEALSFHHRVQAAYLRLLADHPDRIKRVDASQPLDQVVTQALEIMASQLPTYVASKGGEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW6</accession>
    <name>F9UKW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent carboxylate-amine/thiol ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101023.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888495.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0484"/>
    <dbReference type="EnsemblBacteria" id="CCC77981">
        <property type="protein sequence ID" value="CCC77981"/>
        <property type="gene ID" value="lp_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0484"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.398"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_9"/>
    <dbReference type="OMA" id="CYMNIAS"/>
    <dbReference type="PhylomeDB" id="F9UKW6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-402-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="94"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="33049" checksum="615C353ED83A0D2B" modified="2011-10-19" version="1">MPNQVLFCITKMRYEEKRIYHYLEESGLSIKIMLDSSNLDEVVAHNSDYCLCIVRVMSQHRAFRIAEYMEALGIPTLNSSRAIQICADKAIQALILANRDVIKQPHFSILRNYEDLSNFNGKMVVKPVSSSWGRGISLIENEDALTTWKISHQELDIQNQNLPYLIQEFIDKPNYDVRIVIINTKPVVAFKRVSANNWKTNTHLGATVVPIVIDDSINKIVTEIIKVVGPGIYGLDLMKNRQNEWIFCEINQNPEFAHSWKIHHVDVAEKIAQYVSSKVKVGQKNASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY6</accession>
    <name>F9UKY6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101039.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78001">
        <property type="protein sequence ID" value="CCC78001"/>
        <property type="gene ID" value="lp_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0509"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.418"/>
    <dbReference type="eggNOG" id="ENOG5030AMZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2862192_0_0_9"/>
    <dbReference type="OMA" id="LNMNPQH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-422-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="64" mass="7647" checksum="8D3DE2AB7B12CB27" modified="2011-10-19" version="1">MLTPNEIRRRLRRDLVTIAEAYQIGFESRLYTEAEYENLKQTLLQLRELNMNPQHMEQLLAING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL36</accession>
    <name>F9UL36_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nadC1</name>
        <name evidence="12" type="ordered locus">lp_0565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101056.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888565.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0565"/>
    <dbReference type="EnsemblBacteria" id="CCC78051">
        <property type="protein sequence ID" value="CCC78051"/>
        <property type="gene ID" value="lp_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0565"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.469"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_2_1_9"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="PhylomeDB" id="F9UL36"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-481-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="158"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="362"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="492" mass="56107" checksum="548587EB333F1FD4" modified="2011-10-19" version="1">MTQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVVNYINHLHFTATDIAYLRELGGYSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGPLATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEFGTRRAQEFDAAIWGTRAAYIGGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRSGVPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTIQNLKMQGAKISVWGVGTKLITAFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTPGQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPSYTYINKTVSDFDARPLLVPIYDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVRDHVNHKDEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL73</accession>
    <name>F9UL73_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, PilT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640931.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888602.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0607"/>
    <dbReference type="EnsemblBacteria" id="CCC78088">
        <property type="protein sequence ID" value="CCC78088"/>
        <property type="gene ID" value="lp_0607"/>
    </dbReference>
    <dbReference type="GeneID" id="57024383"/>
    <dbReference type="GeneID" id="66448650"/>
    <dbReference type="KEGG" id="lpl:lp_0607"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.508"/>
    <dbReference type="eggNOG" id="COG4956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050839_0_0_9"/>
    <dbReference type="OMA" id="TMPTDLL"/>
    <dbReference type="PhylomeDB" id="F9UL73"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-519-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="391" mass="44332" checksum="0A61AB1C64520E1B" modified="2011-10-19" version="1">MKKLTVRLVFIVVGGTLGLTYLPFLWTTILSQPNVLLNNVFTNFLLGALILWVLSLFLANAAVRLVDRVEKNLSKQNPMTLLFGSIGFIIGLLIAVLISQLFNRSPLFLLNTVVPIILMLFFGYIGARVGTTRIDEWRKVFNFRRREKETSPEITDAQPDQNYHHYKILDTNILIDGRIYDIVKTGFLEGTLLVPNFVLYELQYIADSADSIKRVRGRRGLDILNKLQNENIIPVEMYEGDFEDIPEVDSKLIQLAKKVNGVIVTNDYNLNKVIEFQNVQVLNINQLAKSLKPRVIPGEEMNVMVVKNGSERQQGVGYLDDGTMVVVEDGKFYINEKVDVVVTSALQTDAGRMIFARLAHANRGIPDHADGNNKHNNNHSNNRNNNRDNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULE5</accession>
    <name>F9ULE5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3591"/>
    <dbReference type="EnsemblBacteria" id="CCC80552">
        <property type="protein sequence ID" value="CCC80552"/>
        <property type="gene ID" value="lp_3591"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3591"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2996"/>
    <dbReference type="eggNOG" id="COG2364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110210_0_0_9"/>
    <dbReference type="OMA" id="CASIFTE"/>
    <dbReference type="PhylomeDB" id="F9ULE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3039-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045678">
        <property type="entry name" value="DUF6198"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19700">
        <property type="entry name" value="DUF6198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="26055" checksum="7B89E585294132CE" modified="2011-10-19" version="1">MAVTKLVMPNHDWLKRWLFLGLSLLINSIGHALTVVMNLGSAVWTASAVNLYHLWPLSLRATLFTCGVLVVTMNAILIHQIIWRRVIGNLLFTLPFSFLIQWFTDLIQRSEIAELPLALRIVIDVFGVLCVALATSIYQRANLVLHPNDDFMQIIRFRYVHGNATVAQIVHYIPPIIIMMITFGVSGHLWAVNVGTVICLFFQGTFIGFFDKHIFLNLKHYGLDTIQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH5</accession>
    <name>F9ULH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2008-03" db="PDB data bank">
            <title>Crystal structure of a transcription regulator from lactobacillus plantarum.</title>
            <authorList>
                <person name="Sugadev R."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 56-335</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102263.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3CLK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.08 A"/>
        <property type="chains" value="A/B=57-335"/>
    </dbReference>
    <dbReference type="PDBsum" id="3CLK"/>
    <dbReference type="SMR" id="F9ULH5"/>
    <dbReference type="STRING" id="220668.lp_3625"/>
    <dbReference type="EnsemblBacteria" id="CCC80582">
        <property type="protein sequence ID" value="CCC80582"/>
        <property type="gene ID" value="lp_3625"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3625"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3026"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_9"/>
    <dbReference type="OMA" id="HHVAIDN"/>
    <dbReference type="PhylomeDB" id="F9ULH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3069-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3CLK"/>
        </source>
    </evidence>
    <sequence length="335" mass="36631" checksum="E2BC494614F3E6D1" modified="2011-10-19" version="1">MSVTIKDIARKVGVAPSTVSRVLSNKSKYYTSETAEMVRKAARELGYKKNQAAVELVKKSSNVIAAVVSSVRTNFAQQILDGIQEEAHKNGYNLIIVYSGSADPEEQKHALLTAIERPVMGILLLSIALTDDNLQLLQSSDVPYCFLSMGFDDDRPFISSDDEDIGYQATNLLINEGHRQIGIAGIDQYPYTGRKRLAGYKKALKEANIAINQEWIKPGDYSYTSGEQAMKAFGKNTDLTGIIAASDMTAIGILNQASSFGIEVPKDLSIVSIDGTEMCKITRPQLTSISQDFFQMGVTGVQQIHQSVKNGSNRIVSQQFIPVNPVIRKSTARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULH7</accession>
    <name>F9ULH7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exo-alfa-1,4-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.10</ecNumber>
            <ecNumber evidence="4">3.2.1.2</ecNumber>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="4"/>
    <dbReference type="EC" id="3.2.1.2" evidence="4"/>
    <dbReference type="EC" id="3.2.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891098.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3627"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80584">
        <property type="protein sequence ID" value="CCC80584"/>
        <property type="gene ID" value="lp_3627"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3627"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3028"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="OMA" id="WNQPEVH"/>
    <dbReference type="PhylomeDB" id="F9ULH7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3071-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102229">
        <property type="term" value="F:amylopectin maltohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016161">
        <property type="term" value="F:beta-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="12"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="558" mass="64961" checksum="8808703FA5D36143" modified="2011-10-19" version="1">MEKWWKNAVVYQVYPSSYQDSNNDGIGDLPGITKRLDYIKKLGVDIVWLSPIYKSPQVDNGYDISDYRAINPDFGSMEDFDKLLGKAHDLGLKIMMDLVVNHTSDENKWFEESRKSKTNPYRDYYIWRDGNAGKSPNNWGSFFRGPAWKYDEQTGQYYLHLFAPQQPDLNWENPNVRHSVYDMMNWWASKGVDGFRMDVINYISKPEGLPDAQLQADEELGNPEPLVANGHRVHEFLQEMNNKVMSKHRMVTVGEAPSVTTDEAIKYAGLDGKELDMVFQFEHMGLDGNENPVLGHWSDRKASLKDLRSNLTKWQEALEGKAWNSLYWNNHDQPRVVSRFGDDSNEEYRVLSAKMLATMLHLQQGTPFIFEGEEIGMTNSYFKKLSDYVDLDSINTYHQFVDKQHLVGSQTMLKYLAMHSRDNARTPMQWNSTDNGGFSKHEPWEHVNPNYKHINVKQSLDDPNSIFYYYQKLIRLRHELPVITDGKYRLVKGNEDDEAVYAYTRKDENTTLLVILNYTKTTLDRDYQVPDNAELVINNYPDDKGNTLRPYEAKVYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULI7</accession>
    <name>F9ULI7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two-component system histidine protein kinase sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yesM</name>
        <name evidence="7" type="ordered locus">lp_3639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102273.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3639"/>
    <dbReference type="EnsemblBacteria" id="CCC80594">
        <property type="protein sequence ID" value="CCC80594"/>
        <property type="gene ID" value="lp_3639"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3639"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3038"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_3_9"/>
    <dbReference type="OMA" id="DYSRHDN"/>
    <dbReference type="PhylomeDB" id="F9ULI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3081-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="570" mass="64111" checksum="0D182D3A685DE257" modified="2011-10-19" version="1">MLLKSHAMQASFAHLIKLYTTIISVMVVLATTVFITVSIRTYDADLEQAENTAIVQVGQMLNQNQQIAAQFATQMTSSSSNLPSIEKYFDSSITDYSNYAIDKSISGSPYFFWPTESRQFFTQHDQVTQLTLRLLSQNKVFVATQANPGGALYPAKDVKQRFAINAPLINQTSLETDGVLSISFDQSEIKRQLSQVNATQPLQVVVRSEADDEVFYFAGKRVTRQQQSDLNQALTAGNMKMLRDYHVTTKQLSSGYTVMTVLNRHLLSRLIIGHVLPLILLGLILLLGLSTGLWLTFRRYQHQLNTIVDTVQTVSDGNLDARVPMNLRPTDLHTLAGGINAMLTEIHQHIYTIYQLQIAQQEANRRALQAQINPHFMSNTLEYIRMAALEAHQPELANVVYSFAALLRNNTDLSSRTTLKQEVSFIEKYVFLYQVRFPDRLAYQFTVADDVAAVEIPKFSLQPLVENYFVHGVNFSRVDNALSLKAWREAGIVHVKIVDNGRGLSPEAVKAVNQKLKQPLAAEQQHSIGLQNVYSRMHDSFGDGFKMTINSNDQQGVTVLLQFDDREGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK9</accession>
    <name>F9ULK9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhE</name>
        <name evidence="5" type="ordered locus">lp_3662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643605.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3662"/>
    <dbReference type="DNASU" id="1061605"/>
    <dbReference type="EnsemblBacteria" id="CCC80616">
        <property type="protein sequence ID" value="CCC80616"/>
        <property type="gene ID" value="lp_3662"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3662"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3060"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_1_0_9"/>
    <dbReference type="OMA" id="QWFKVPP"/>
    <dbReference type="PhylomeDB" id="F9ULK9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3103-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="463"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="867" mass="94554" checksum="ABCE727482BE4F81" modified="2011-10-19" version="1">MIKTEKNQTSKVTDEVDQLVQRSKKALAILKSYTQAQIDDLCEKVAVAALDNHMKLAKLAVEETGRGVVEDKAIKNIYASEYIWNSMRHDKTVGVIKEDDEEQLMEIAEPVGIVAGVTPVTNPTSTTVFKTLISLKGRNTIVFGFHPQAQKCSSAAADVMREAIKAAGGPADAVLYIEHPSIEATDALMHHTDVATILATGGPSMVTAAYSSGKPALGVGPGNGPTYVEKTADIKQAVNDIVLSKTFDNGMICASENSAIIDKEIYAEVKAEFIRLGCYYVKPKDVQALSDAVIDPNRHTVRGPVAGKTAYQIAQMAGLKDVAKDCRVLIAEINGVGIKYPLSGEKLSPVLTVYKADSHEAAFKRANELLHYGGLGHTAGIHTTDDALVKEFGLQMPACRILVNTPSSVGGLGNIYNNMAPSLTLGTGSYGGNSISHNVTDMDLINIKTVAKRRNNMQWVKMPPKVYFERNSVRYLEHMAGIKKVFLVCDPGMVEFGYADRVTAVLNKRTDPVDIDIFSEVEPNPSTDTVYKGVARMKAFKPDTIIALGGGSAMDAAKGMWLFYEHPEASFLGAKQKFLDIRKRTYKVPVSEKVTYIGIPTTSGTGSEVTPYAVITDSKTHVKYPITDYAMQPDIAIVDPQFVETVPKRTTAWTGLDVITHATEAYVSTMASDFTRGWSIQALQLAFKYLKASYDGDKMAREKMHNASTLAGMAFANAFLGINHSIAHKLGGEFNLPHGLAIAITYPQVVRYNAEIPTKLAMWPKYNHNTALADYANIARALGLPGKTDEELKESLVKAYIDLAHSMDVTLSLKANRVEKKHFDATVDELAELAYEDQCTTANPREPLISELKAIIEREWDGQGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN2</accession>
    <name>F9ULN2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0643"/>
    <dbReference type="EnsemblBacteria" id="CCC78121">
        <property type="protein sequence ID" value="CCC78121"/>
        <property type="gene ID" value="lp_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0643"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.537"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074315_1_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-554-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025400">
        <property type="entry name" value="DUF4373"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14297">
        <property type="entry name" value="DUF4373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4373" evidence="3">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="35329" checksum="7DF459927F93B944" modified="2011-10-19" version="1">MARPVKEGLDYFPLDVDFAVNDKTEAIMGEFGPKGVLFMIYLLSAVYQNGYYLQWNKLKQMQLANRIEGVSPELANQIVNRLIAYGTFSEELFNSAKVLTSQRIQETYEDATKRRKSQKPTKYWINADINKDTSVVNVDINTQSKVNKSKSNKSKVNNYDDDAGVTREQVINDWTNLWGFPNGIARPEIDEWLEEFKPEVIAYAIWVAGEHQIGSNACLKYVRAIVAGWKKRNITTLEQAKKAAANHDDRMKSERKPSGYSKPRRKEVTPKWMQNGASQADSKPSSSDNEQDDMSDEAFLAFMNSQEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR6</accession>
    <name>F9ULR6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888669.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0678"/>
    <dbReference type="EnsemblBacteria" id="CCC78155">
        <property type="protein sequence ID" value="CCC78155"/>
        <property type="gene ID" value="lp_0678"/>
    </dbReference>
    <dbReference type="GeneID" id="57025310"/>
    <dbReference type="KEGG" id="lpl:lp_0678"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.570"/>
    <dbReference type="HOGENOM" id="CLU_1127961_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-589-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="246" mass="27666" checksum="F72C6E43B8A55FF9" modified="2011-10-19" version="1">MSIKELQDVTGTVIHPRTETAAIVDADKLVNTTSTQNNIAGIKNFVDGISIKGVPLLDIDFNKVKLVPNDDVYQIKQAGLYFYTTNTKNVPLLSSRFHDGFVLYGAKDTKTAFLYYIGARVYQERFQGKWLRQESSIPQDLWVGEGKVGDVLKLRDTLDNYRQLRFRCYFTIGNTLQFIPAWASDNMLYLTQPALNFDGTILRALEVALQIGQDQRSLIIKSAKYFANGKSTSITDGFLKEVGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS3</accession>
    <name>F9ULS3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101135.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888676.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78162">
        <property type="protein sequence ID" value="CCC78162"/>
        <property type="gene ID" value="lp_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0686"/>
    <dbReference type="HOGENOM" id="CLU_2450889_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-596-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="89" mass="10300" checksum="5702C253851F2BCB" modified="2011-10-19" version="1">MLTKLKPISGISFGYSDGKNEARQPNFESLFYDGSGYYRTLRNDPLKYLVVGRKGTGKTILVRYFMKKMQEEKILFQNLLLLEILQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ2</accession>
    <name>F9ULZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH oxidase</fullName>
            <ecNumber evidence="5">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nox2</name>
        <name evidence="5" type="ordered locus">lp_0766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646086.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888745.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0766"/>
    <dbReference type="EnsemblBacteria" id="CCC78231">
        <property type="protein sequence ID" value="CCC78231"/>
        <property type="gene ID" value="lp_0766"/>
    </dbReference>
    <dbReference type="GeneID" id="57024472"/>
    <dbReference type="KEGG" id="lpl:lp_0766"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.647"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_9"/>
    <dbReference type="OMA" id="FDRAHFM"/>
    <dbReference type="PhylomeDB" id="F9ULZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-666-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="329"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="452" mass="49444" checksum="4C07F9B6AFF1B34B" modified="2011-10-19" version="1">MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALYANPSEFSEQGVQMRMQYDVINVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAIPGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGVELAEGYVKSGHTVTLFQRGPHLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVICPGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSHAIRQGALAGINIFDKRLGAIGTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGNYRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSANTLSVVIHNGNTIDELAFMDMLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ3</accession>
    <name>F9ULZ3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aad</name>
        <name evidence="5" type="ordered locus">lp_0769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641026.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0769"/>
    <dbReference type="MEROPS" id="M15.012"/>
    <dbReference type="EnsemblBacteria" id="CCC78232">
        <property type="protein sequence ID" value="CCC78232"/>
        <property type="gene ID" value="lp_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0769"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.649"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_2_2_9"/>
    <dbReference type="OMA" id="IRTEWWH"/>
    <dbReference type="PhylomeDB" id="F9ULZ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-667-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4 5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="185" mass="20923" checksum="4DC29671B25AB5CE" modified="2011-10-19" version="1">MDQALTGFTNIQHLDSEIIVDLRYATTNNFTHQVIYDFTTAIVRTGTAHKLAKASALVKQQGYRLKVWDAYRPVSAQRRLFEVYPDPEFVAQPNPNFSHQKGVTLDLTLAHPDGSELTMPTAFDDFTAAAHRDAPRTALQEKNYQLLDTAMTAAGFVGYVNEWWDYRDTEMDAYQPLAADPNDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM70</accession>
    <name>F9UM70_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888823.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0858"/>
    <dbReference type="EnsemblBacteria" id="CCC78309">
        <property type="protein sequence ID" value="CCC78309"/>
        <property type="gene ID" value="lp_0858"/>
    </dbReference>
    <dbReference type="GeneID" id="57024550"/>
    <dbReference type="KEGG" id="lpl:lp_0858"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.729"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_4_0_9"/>
    <dbReference type="PhylomeDB" id="F9UM70"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-745-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15063" checksum="7814FE83E991E474" modified="2011-10-19" version="1">MEELRLSDFPILYTTQAVNEDGIEGHAYIPNGLEVAVSSPLKAVPGSNPEQLIGLALSTCLNATLEAIEKEHGQTHQSKVVTTVKMSRDRFGYQFFLDARVTIPEVDAETAARWLAIAETRCPVAKLVGPSANVTIQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM96</accession>
    <name>F9UM96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_0893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888849.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0893"/>
    <dbReference type="EnsemblBacteria" id="CCC78335">
        <property type="protein sequence ID" value="CCC78335"/>
        <property type="gene ID" value="lp_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0893"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.756"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_9"/>
    <dbReference type="OMA" id="AMFLRPI"/>
    <dbReference type="PhylomeDB" id="F9UM96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-771-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="385" mass="41923" checksum="437AE7C376198C13" modified="2011-10-19" version="1">MMKTRLYTPDVKLVLMASFFFLMSPMLINPVIAGFAHGIGASSVLAGTIAGLTNLTSLVLRPLAGNLTDRVSKYRLTFVGGCLLLLASLGYSLTTNVTLIMLLRILNGLGYTLCSVCMATWMASLLPPDRIGSGMGIYGLANALGMACGPAISVFLYQHYSYQSVFWLAAGCSLLLVIMIQFVGDHGEPIVTPQTATTKHHIRIVQPRVIPVALILLLFSLPYFATQTYIVSYVAARHFHVAAGVFFPVYAGILLVLRIILRDWFDRVPFKRFIWLCLIFNLLGLIGLTDMNNWAMLLLGAAGLAAGYGLMFSICQAKALMLVPKADHGLANSTFYIGVDLGMSLGPIIGGLISSQLPMAWFYPVMMVTLPLIIVVYLVSRRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMB2</accession>
    <name>F9UMB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ISP2_2</name>
        <name evidence="9" type="ordered locus">lp_0911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0911"/>
    <dbReference type="EnsemblBacteria" id="CCC78351">
        <property type="protein sequence ID" value="CCC78351"/>
        <property type="gene ID" value="lp_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0911"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.771"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="OMA" id="VDTKHHL"/>
    <dbReference type="PhylomeDB" id="F9UMB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-787-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="DUF772" evidence="8">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="577" mass="67433" checksum="01541C4F86EACD84" modified="2011-10-19" version="1">MQDYYNMNQTTLSIALDYQPEEHHSARYINQLVESLKLKYDYQFGRPREYNLGAMLKLVLLAYSYGIFSSRKIERFARENKPAGWLIADQIPSYRTICRFRISDELATLTTDSLSQLTQYLRQNGMIDDVSFIDGTKILADANKYSFVWKKNTIRFDKMNREKLVDLLGELHEAKIVGEIPAGSELTPELLDIMISKVEDHLVVLNETVEATKQVSPNPAKQQRRTVKSQKRKLDKRRDKMREHQAQQAIYDQRNSYSKTDHDATFMRVKEDPMQNGQLKPAYNVQIATSNQFITGYRLFQNPTDTRTLQPFIEHLKANNVLGHTIVADAGYGSESNYRYLEDEFGQHTVLIPYGTMLKENSRKWQSDDRKVMNWDYHEKDDYFINPQNVRFNFNAYRQRTDKYGFTRDFKEYIAEKYDENHQLISAALTPKGYLKRISVNENWEYFKSKQRELLSAPETGQIYAQRKIDVEPVFGKMKASLHFNRFSVRGFDKVTKEAGIVILALNIMKLVTVGTNFKNQRRKQMGRETKIRFLVPFAYTEASYVTASFLVLLVKEILRCVRMISSGTVRDLCRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME1</accession>
    <name>F9UME1_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">lp_0945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101220.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888894.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_0945"/>
    <dbReference type="EnsemblBacteria" id="CCC78380">
        <property type="protein sequence ID" value="CCC78380"/>
        <property type="gene ID" value="lp_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="57024621"/>
    <dbReference type="KEGG" id="lpl:lp_0945"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.802"/>
    <dbReference type="eggNOG" id="COG0406">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129249_0_0_9"/>
    <dbReference type="OMA" id="CIACVTH"/>
    <dbReference type="PhylomeDB" id="F9UME1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-816-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="176" mass="19615" checksum="14C32188DA71C595" modified="2011-10-19" version="1">MKVYLIRHSEPTYEQVTTAGLTGFGRELGSLTDRGIMLAQQCAQQPLFAQVQLILSSPYTRALQTALEIVRFNDIPLKVELGLHEWLPDDTGSRTDTDEQAATAYKLYRQHAGKRTAASPRPYESAAEMKARVLATLNKYAVSYDCIACVTHGEVMRQFGNQKDVDYCGVRVIAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG0</accession>
    <name>F9UMG0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101231.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888913.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0966"/>
    <dbReference type="EnsemblBacteria" id="CCC78399">
        <property type="protein sequence ID" value="CCC78399"/>
        <property type="gene ID" value="lp_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0966"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.822"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097499_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-835-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="254" mass="28262" checksum="5B2D7986D2800EF6" modified="2011-10-19" version="1">MKVLGILGAHRADGVTAQLLQSVLKGAAASADTELVNLNDYELRPDHDSQPNADLDALEAKLMAADVWVLAAPTYLGSLSGVMKNFCDCFRGRIARFNSVGEAVPDRFKNKHYVTITDCYAGGIENYLTGVTDATFKTLDKFLTMGGLIKLREIVVTKTWGMQTITAAKQAECERVGARAAHKKERDDSTVKRYIQLFFMIAVMALLTMGIEAGIQQLIPLNNFWAYYGVFVVVFYVLLAMILHFFTVVKHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH5</accession>
    <name>F9UMH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular lipoprotein, Asp-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101240.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888928.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0988"/>
    <dbReference type="EnsemblBacteria" id="CCC78414">
        <property type="protein sequence ID" value="CCC78414"/>
        <property type="gene ID" value="lp_0988"/>
    </dbReference>
    <dbReference type="GeneID" id="57024655"/>
    <dbReference type="KEGG" id="lpl:lp_0988"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.838"/>
    <dbReference type="eggNOG" id="ENOG50309ND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727213_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-850-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388839" evidence="2">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="380" mass="42074" checksum="E849155AB94E18D2" modified="2011-10-19" version="1">MKSGKHRVSLLILLCLMVVGLAGCHNKAYSQSIEKGLNAVAENKYQKALTYFDNALAQKPKDEKAQAYRDQTQAYLTTTSELKAGKVKTALTTVDKGVKITNGATSLTNKLKQLKVTVTSDYQEYQQLSDDVKAQLKVKNGNYSADVLKRCAAINWDKKPYLKPLKAKVKQLLTAAKKAKTNMKVSAAEAKRAAALRRKIAAAKNKWNMAALDDVPDWFILALFADDSDVDDAAEELDDEYADQADDNDDYSDWDEQTTDSNDDTNDTDADSADDDWSDQDTDSNDDTDDDSDTNSDADSDSDYSEDDDDEDSNRDDADDSETQSDDDYDDDTDSESDDDDYDTDDQYDDDDDYDDAESLLNPAPVQPSVADRLFASASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMR5</accession>
    <name>F9UMR5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Citrate lyase regulator, SorC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">citR</name>
        <name evidence="3" type="ordered locus">lp_1103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641300.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889018.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1103"/>
    <dbReference type="EnsemblBacteria" id="CCC78504">
        <property type="protein sequence ID" value="CCC78504"/>
        <property type="gene ID" value="lp_1103"/>
    </dbReference>
    <dbReference type="GeneID" id="57024750"/>
    <dbReference type="KEGG" id="lpl:lp_1103"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.933"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054506_1_1_9"/>
    <dbReference type="OMA" id="SSWSQTI"/>
    <dbReference type="PhylomeDB" id="F9UMR5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-947-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="58"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="35594" checksum="074BA46262972A4B" modified="2011-10-19" version="1">MDDMNHRRLLIGIAHDYYLSKINIAEISKKYQVSRYLISKYLDEAMATGLVKININTPIERNSELEAKFKHRFPIEHIYIIKDADTTSDDERHVIEFAAETIQRQIIQSNVIGVAWGGTVLSVIDNFQTSTRDDLLFTQFMGDNLKTNAANGSTPLVQKAAAKFGAQYVTIPAPLYLFNDQAHQALAQEPAITPAISNFDRMDMLFAGIGTLASIDSIPVWHQHRQAILGGADPQAVVGLLYGRPYDINGHILNADHDKLFGAKMPAILKVPRRFGIIKSKFKSEALLGALRGQLLTDIIIDEAVANRVLQEDQATPLSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS6</accession>
    <name>MLES_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malolactic enzyme</fullName>
            <shortName evidence="3">MLE</shortName>
            <ecNumber evidence="2">4.1.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mleS</name>
        <name type="ordered locus">lp_1118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1983" name="J. Biol. Chem." volume="258" first="4907" last="4910">
            <title>Malolactic enzyme of Lactobacillus plantarum. Purification, properties, and distribution among bacteria.</title>
            <authorList>
                <person name="Caspritz G."/>
                <person name="Radler F."/>
            </authorList>
            <dbReference type="PubMed" id="6833282"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>COFACTOR</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate + H(+) = (S)-lactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:46276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="EC" id="4.1.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">0.012 mM for manganese</KM>
            <KM evidence="2">0.059 mM for NAD</KM>
            <KM evidence="2">9.5 mM for (S)-malate</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.101" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101261.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889029.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UMS6"/>
    <dbReference type="SMR" id="F9UMS6"/>
    <dbReference type="STRING" id="220668.lp_1118"/>
    <dbReference type="EnsemblBacteria" id="CCC78515">
        <property type="protein sequence ID" value="CCC78515"/>
        <property type="gene ID" value="lp_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1118"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.945"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_9"/>
    <dbReference type="OMA" id="QMWDPVY"/>
    <dbReference type="PhylomeDB" id="F9UMS6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-958-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043464">
        <property type="term" value="P:malolactic fermentation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000435671" description="Malolactic enzyme">
        <location>
            <begin position="1"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="6833282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="6833282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="547" mass="59465" checksum="1BE828D5F4DF292E" modified="2011-10-19" version="1">MTKTASEILNNPFLNKGTAFTKEERQALGLTGTLPSKVQTIDEQATQAYAQFKSKPSRLEQRIFLMNLFNENRTLFFHLMDEHVVEFMPIVYDPVVADSIEQYNELFLDPQNAAFVSVDAPEDIEATLKNAADGRDIRLVVVTDAEGILGMGDWGVNGVDIAIGKLMVYTAAAGIDPSQVLPVSIDAGTNNQKLLDDPLYLGNRHKCVSGEQYYDVIDKFVAAEQQLFPDSLLHFEDFGRDNAQVILDKYKDQIATFNDDIQGTGMVVLAGILGALNISKESIKDQKILSFGAGTAGMGIANQILDELMQAGLTEEEAKQHFYAVDKQGLLFDDTEGLTPAQKAFTRKRSEFSNADELTNLEAVVKAVHPTVMIGTSTQPGTFTESIIKEMAAHTERPIIFPLSNPTKLAEAKAEDLIKWTDGRALVATGIPADDVEYKGVTYQIGQGNNALMYPGLGFGLIASTAKVLNAETLSAACHALGGIVDTSKPGAAVLPPVAKITEFSQKLAEVVAQSVIDQKLNKEPIADAKQAVADMKWVPEYRAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN53</accession>
    <name>F9UN53_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">oppC</name>
        <name evidence="8" type="ordered locus">lp_1263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889156.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1263"/>
    <dbReference type="EnsemblBacteria" id="CCC78642">
        <property type="protein sequence ID" value="CCC78642"/>
        <property type="gene ID" value="lp_1263"/>
    </dbReference>
    <dbReference type="GeneID" id="66449139"/>
    <dbReference type="KEGG" id="lpl:lp_1263"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1073"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_9"/>
    <dbReference type="OMA" id="YYRVVRN"/>
    <dbReference type="PhylomeDB" id="F9UN53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1083-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="141"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="37577" checksum="1B4E2674A23106A7" modified="2011-10-19" version="1">MAENPSSIDIKPGDFEPLDKQAGPDNERIAAPSLTFGQDVWRRLKSNKTAFISFIVLVFLFLVAFGGRAVYHVDPNAQSPRYANLPPKIPGVSIHGLNGHLTQSGKDVDAYAAAGAKSDVHYLLGTDYLGRDLLARIMYGTRISLEIALIATLIDLTIGVGFGILSGWKGGRVDLFMQRVIEILSSIPQLVIMVLMATAFTKTGMASIIAAIAITGWTTMARLTRAQTLQLKNQDFILAARTLGESPVKIAWKHLLPNLSSVIIIQTMFTIPSAIFFEAFLSYIGIGISSPQASLGTLISDGQKNFQFLPYQMWYPAIVLIILMLAFNLLGDGMRDAFDPKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN59</accession>
    <name>F9UN59_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphocarrier protein HPr</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ptsH</name>
        <name evidence="11" type="ordered locus">lp_1273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="function">
        <text evidence="9">P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPr family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889162.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1273"/>
    <dbReference type="EnsemblBacteria" id="CCC78648">
        <property type="protein sequence ID" value="CCC78648"/>
        <property type="gene ID" value="lp_1273"/>
    </dbReference>
    <dbReference type="GeneID" id="49393529"/>
    <dbReference type="GeneID" id="57024889"/>
    <dbReference type="GeneID" id="66449146"/>
    <dbReference type="KEGG" id="lpl:lp_1273"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1080"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_9"/>
    <dbReference type="OMA" id="SIMAMMM"/>
    <dbReference type="PhylomeDB" id="F9UN59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1090-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9383" checksum="6464373A3C02D7D4" modified="2011-10-19" version="1">MEKKEFHVIADTGIHARPATLLVQSASKFNSEITLQYQDKSVNLKSIMGVMSLGVGKDADVTISAEGADEADAIAALTETMKKEGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA0</accession>
    <name>F9UNA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxynucleoside kinase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dgk2</name>
        <name evidence="6" type="ordered locus">lp_1329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643169.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889203.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1329"/>
    <dbReference type="EnsemblBacteria" id="CCC78689">
        <property type="protein sequence ID" value="CCC78689"/>
        <property type="gene ID" value="lp_1329"/>
    </dbReference>
    <dbReference type="GeneID" id="57024945"/>
    <dbReference type="GeneID" id="66449196"/>
    <dbReference type="KEGG" id="lpl:lp_1329"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1121"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_9"/>
    <dbReference type="OMA" id="CVQDRTL"/>
    <dbReference type="PhylomeDB" id="F9UNA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1147-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="5">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="24934" checksum="E8014AE9B2A83821" modified="2011-10-19" version="1">MVIITAGMIGVGKTTLTGLIADHLGTKAFYEPVGDNPVLPLYYSDPKNYGFLLQIYFLNKRFAMIKKALADDNNVLDRSIYEDALFTKENNAEGNISDTELNVYLQLLDNMMTELTELPKKAPDLMVYSETDFDTILYRIKKRGRDYEQFDHNPELESYYYKMWTAYRKWYDEYDASPKMKIDLQQYDLEKPANQQAVLAQIDSELGKIRNPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNC4</accession>
    <name>F9UNC4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound protease, CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101372.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78713">
        <property type="protein sequence ID" value="CCC78713"/>
        <property type="gene ID" value="lp_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1359"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1144"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079560_3_1_9"/>
    <dbReference type="OMA" id="RIDYNIF"/>
    <dbReference type="PhylomeDB" id="F9UNC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1171-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="24787" checksum="AF0B4E530AF1EC83" modified="2011-10-19" version="1">MGWLGRVLLTAGLIVGVVIPPMLLKLINQLYRQHQLTAWQITLAGVYLLIFVILALAATALMRHYTGNYQSENLQHHDWQIIGMAYLTILIFEGGFQFINQLLYHQNQTQNNAAIKNLMAGSPLSLWLMALSAVFLTPIVEELVFRGVLTNLFFQQEWLKVGLSGIVFGSLHSSSTLPSFLIYVTMGLVLAIVYRLTRKIRAAIALHFVINGLAITIMLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE1</accession>
    <name>F9UNE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/sulfate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_1385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101381.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889244.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1385"/>
    <dbReference type="EnsemblBacteria" id="CCC78730">
        <property type="protein sequence ID" value="CCC78730"/>
        <property type="gene ID" value="lp_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1385"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1161"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_2_9"/>
    <dbReference type="OMA" id="IHWQSLV"/>
    <dbReference type="PhylomeDB" id="F9UNE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1190-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="298"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="591" mass="64411" checksum="6AE5A68D6334B2F5" modified="2011-10-19" version="1">MTLNIAIVLITLLVSFILMAMEVTTPNAVILCALAFLMFVGILSPTDALSGFANDGLATIALMYIIAYAIAKSNIIIRLFDRILGDGHSEKRSLLRLLASVSVISPFMNNTPIVSTLTPMVQRWTKQKGMAISKFLIPLSYATILSGLLTVLGTSTNLVAQGLLSKYKLAQFGTFDLAVIGIPITIIGLIYLLTIGYRMLPTYYGSSVDDVVAEPNDYLIEMTIGDEFEHLNQTVVAAKLRNLPRSFLVAINRSGQSIVPVTDETILQLGDRLYFTGNFDCINDLMNIKGLIPSTQKINMTDITNERVRLVEVSIPDTSSLVNQTVKSARFRNVFGSVVVAIRRNDVNLKGHLGSIRLKGGDNLVMITTGEPDELASLKDLHVFNSQPVKSRKHTYKDVLPIVLLVATIIVSTMGVIDLFVGLAASCVVLFLTKCVSISDIVKAVDMNVLFLVASSYGLGLAMSNVGADKFIAKSLVAITGNASPIIYMFLIYFVTNFLTAILSNAAALSLMFPVVVSAAKLENLPVMMLVMLITIAATADFSTPIGYQTNLIVYGPGHYKFTDYFKVGIPLNLICMVVCVFVSYYYYMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF6</accession>
    <name>F9UNF6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport protein, major facilitator subfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101392.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889259.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1402"/>
    <dbReference type="EnsemblBacteria" id="CCC78745">
        <property type="protein sequence ID" value="CCC78745"/>
        <property type="gene ID" value="lp_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1402"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1176"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058800_0_0_9"/>
    <dbReference type="OMA" id="WFLTANA"/>
    <dbReference type="PhylomeDB" id="F9UNF6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1206-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="394" mass="43920" checksum="50E41468B5353139" modified="2011-10-19" version="1">MKKEFRPHPNDRHNLLCYLSSMLITFFGFYSFTYLVTWLTIEKTGDPQLLGNVMAMTMLPAIGLNLVAGRVLKYYSAKQMMFITDILTGILFIGAYYALNTVSWQITCLVIVAVLNKSIGVFYKLSNKTILPDLFAPVNIQIVNGYQTQIRQLAIVSATMLVTMALLWVTPATLILIMGIAFLVSAGLDWQFRTRSNLSSDSVVTVKLDRHRSWPTWSLLYAVLGYLVDATIAVAVPWLVVSKLHSHWPLSWFLTANATGILLAPLLLKRWSKQSLLTLTAFTGGCLLLMWPTFASLMITMFLIGALRGQINISFFTTIQQIPTNNRNILMTGVLTVIDTTTVIGSLLAPRLILMLGSWTLPLLGGGILLFCLTRLIILLNNQKQSSSDIDENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI8</accession>
    <name>F9UNI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101409.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889291.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1446"/>
    <dbReference type="EnsemblBacteria" id="CCC78777">
        <property type="protein sequence ID" value="CCC78777"/>
        <property type="gene ID" value="lp_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1446"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1210"/>
    <dbReference type="eggNOG" id="ENOG50303XB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296441_0_0_9"/>
    <dbReference type="OMA" id="GAYDFPI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1238-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="888"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1092" mass="113068" checksum="D91DA58706BE2C64" modified="2011-10-19" version="1">MQRPRRLITAWLGLLVLLMSLLVVNGGAIYATATTTATPIKFEKPPTELVIGQPFTLQLAVQGSQEHQVMVAIPEALTVDQTKTRQANRASLAELDFDADNRKLTLTPSDPTASTTFDLVLSASEAKTYKVTAEALITGPALATTTASAVASSEKPTTHTMTAEPITFTVAAGSAVDSPPEEAGTESAREVSNDAESTSSASQDPTTDDSSATATQAATTKRDDNNATSKSSEQSSSTTATSDPTADNDTATSRTAQADSEVERAPKATATKAANDITTAAIVVNPDGSTTVSTYDDLKSAYTNTAVTTIKLGANITHTSTSATELGTRTTSLTIDGQNHSLDLGIGNFTLGSTTTAQTMTVKNFSSIRGAIASGTSSGGAAGIIQSGTDGGANAGGARWTITVTDLITTSDVYRLVNAPGNQVNVSGAVTATTVAENMITGGMTFAASSTYIGRKANNSAANKAFFNFTATSTVGTGDRKVTIGSAANVNLLGSASDATRGIFYDQYDAVTVGTNAILTAKMYGNVYRAETANTFTANAGSKVTFENLATTSSNALYYVTPLIPLGNNSTFTVTGGELYITSSGSAPIFGGYMSGLSVLLDSPKAYDIKNTDFALLVQTGSIVETTIKSFKITNSNLSMWSLSLLNLLSASVTYQGITAIEQNGVLITNSGSVLPGLLTFSAARRIANTLSLPTVQFSSPYTSDLNAQLVTNADKKVRVRVITGYTESNGTQTPIYAGTGTATVKLTDDQGATQSGTTDSSGYVNFTLDHFPTAGTTMTAQATTTYTSDPVTITVQDKTPPTPVTVKDGKIVADQKTIASGSTTTAGNTLRYTVNGTSAADSNGNAITATAASDGSWSLAMPATKLKANDVIQIFVKDSAGNENPVTSTTYHDATFAAATQYTVAPAIGPTAPTEPEHPGTTNTSGSENTGTGNTGELRLDYAPSQFNFGSVTTSMQPKTYAAQTINGVAKQWLQVSDNRLATHGWTVTARQNSPFTSTSGAQLTGAKLHIPAGQTYNERATGQLKSYAVDLTTAEQPVFAAPATANVGKDLSTNVWQPTQVQLTVPGNTAQAGQTYNTTVTWTLTANVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU8</accession>
    <name>F9UNU8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">lp_1569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889401.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1569"/>
    <dbReference type="EnsemblBacteria" id="CCC78887">
        <property type="protein sequence ID" value="CCC78887"/>
        <property type="gene ID" value="lp_1569"/>
    </dbReference>
    <dbReference type="GeneID" id="49393840"/>
    <dbReference type="GeneID" id="57025157"/>
    <dbReference type="GeneID" id="66449455"/>
    <dbReference type="KEGG" id="lpl:lp_1569"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_9"/>
    <dbReference type="PhylomeDB" id="F9UNU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1348-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="49" mass="6084" checksum="67AAF7C3CC47FC9B" modified="2011-10-19" version="1">MRVHITLECTECHERNYLSSKNRRNNPDRVEFKKYCPREHKVTLHRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV9</accession>
    <name>F9UNV9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ordered locus">lp_1581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640333.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889412.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1581"/>
    <dbReference type="EnsemblBacteria" id="CCC78898">
        <property type="protein sequence ID" value="CCC78898"/>
        <property type="gene ID" value="lp_1581"/>
    </dbReference>
    <dbReference type="GeneID" id="57025168"/>
    <dbReference type="KEGG" id="lpl:lp_1581"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1332"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_9"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="PhylomeDB" id="F9UNV9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1359-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="50973" checksum="C768A239D4072F5C" modified="2011-10-19" version="1">MAKQSYSKDDIRRIVKEENVNFLRLMFTDLFGTIKNVEVPVSQLDKLLDNKLMFDGSSIDGFVRIEESDMYLYPDLSTWLIMPWNTEHGKIARIICEVYTSDRKPFEGDPRNNLIRVLNDMREAGYTSFNCGTEPEFFLFKMNEKGEPTTELNDKGSYFDLSPMDLGENCRRDIALELERLGFNVEASHHEVAPGQHEIDFKYADALSAADHIQTFKLVVKTIARKYNLWATFMPKPLNGVNGSGMHVNMSLFHDQGNAFYDANDKNGLELSSDAYHFLGGLMKHARSYTAVTNPTVNSYKRLVPGYEAPVYVAWSASNRSPMIRIPSARGLSTRLELRSVDASTNPYLAFAAVLEAGLDGIKNGIEPPKSVDRNIYVMDEDERAAAGIADLPSTLHNALKEFQTDPTMKKALGPHIYQSFLEAKRLEWASYRQQVSEWERDQYMELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY9</accession>
    <name>F9UNY9_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ordered locus">lp_1615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101474.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1615"/>
    <dbReference type="EnsemblBacteria" id="CCC78928">
        <property type="protein sequence ID" value="CCC78928"/>
        <property type="gene ID" value="lp_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1615"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1363"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_9"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="PhylomeDB" id="F9UNY9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1390-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="283"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="546"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC78928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="805" mass="90084" checksum="817712BF08932092" modified="2011-10-19" version="1">MAQIAQVLVDVPTMQTNRPYSYRIPTAWQSQVQPGMRVVVPFGRGKRRVQGFVLALDDVTNFDGELKPIDAVVDLAPVLNTEALALTKWLAASTFSFQITCAQTMLPAVMRAKYEKQLRTTATTPATIRTTLFGDQSMVPFDDVATTPAIVSQLLRLQAAGQVDVYYQVKNQARRKTQTAVKAALTNEALQAAVDQVRAGATQQLAVLQGLLTLNGEQLSQKAFCTRFDVTDGAIRTAVQKGWLKKVAVEVYRDPYATSDIKTTKALQLNDEQQVAVDQITQAVDQAATTTFLLEGVTGSGKTEVYLQSMAAALVQGKTALMLVPEISLTPQMVQRVKGRFGKAVAVLHSGLSSGEKYDEWRRIQRGEAQVVVGARSAVFAPLKNLGLIVMDEEHESTYKQDDAPRYHARQVALWRSRYHNCPVVLGSATPSLETRARAEKGVYQRLLLADRVNRRPLPKVSIIDMKKEMQQHAESNFSAPLLVALQDRLERHEQSVLMLNRRGYSSFVLCRDCGFVLKCPNCDISLTLHMDTHTMKCHYCGHEEAIPRNCPNCHSRQIRYYGTGTEKVEEELQDLLPDANIIRMDNDTTRKKGAHAKLLAQFGSGEADILIGTQMIAKGLDFPNVTLVGVLNADTALGLPDFRASERTFQLLTQVSGRAGRAEKSGHVYIQTFNPDHYAIRFAQHHDYEGFFKYEMQMRHRGGYPPYYFTVQITASDLDEGVAAKRMYQLLQWLRPRLAPSTILLGPTPKPIARVNRRYYYQIVIKYKQEPNLAQTLTTLLHETQAQQRQGLQIGIDVEPLHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP51</accession>
    <name>F9UP51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1688"/>
    <dbReference type="DNASU" id="1061546"/>
    <dbReference type="EnsemblBacteria" id="CCC78990">
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        <property type="gene ID" value="lp_1688"/>
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    <dbReference type="KEGG" id="lpl:lp_1688"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1426"/>
    <dbReference type="eggNOG" id="COG1309">
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    <dbReference type="HOGENOM" id="CLU_087539_6_1_9"/>
    <dbReference type="OMA" id="SITELCQ"/>
    <dbReference type="PhylomeDB" id="F9UP51"/>
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="21357" checksum="05D73F3C67CF80BF" modified="2011-10-19" version="1">MNPQTRKRQNLTAVYAALLQLMSQKPLSRISITELCQHAQVSRTYFYRNFANFDQIILAYQKQTILQYLRQLPRQSKVKLQVLMTQYFTLMQQMAATNALLIKNEKTQIFIQSFEAVFALLIKQDRIIGSSNTALRQPYYTAYFSGAVINMLVHWQQNGMVETPAYLAQQVTRFTLRDNESRS</sequence>
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    <name>F9UP57_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ordered locus">lp_1694</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889510.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78996">
        <property type="protein sequence ID" value="CCC78996"/>
        <property type="gene ID" value="lp_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1694"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1430"/>
    <dbReference type="eggNOG" id="ENOG5030C1A">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_2142718_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1459-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
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    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC78996.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12651" checksum="02D0A0302698FFD8" modified="2011-10-19" version="1">MMKQQQKLARLTTVNQLLEQLNTSVPIEKVEIRKLISQAYATINQPDSVTKRYQQIPDAINELIGQLQVMAVAKKYHFSSEQDQLIANLTTSTNKMFAHGWYGLIAMSGIGK</sequence>
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    <accession>F9UP61</accession>
    <name>F9UP61_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase family protein</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_1698</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101516.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1698"/>
    <dbReference type="EnsemblBacteria" id="CCC79000">
        <property type="protein sequence ID" value="CCC79000"/>
        <property type="gene ID" value="lp_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1698"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1434"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_11_0_9"/>
    <dbReference type="PhylomeDB" id="F9UP61"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1463-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="93" mass="10980" checksum="9C9A2E254FF52F80" modified="2011-10-19" version="1">MKVINVALHVKPELTTQYEAFIHELVVNSSQEPGNSFYGHFKQLGHDHNYEIIEHWQDQAAVDFHNKTPHFQNFLAHINEYLITEPEITRMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP68</accession>
    <name>F9UP68_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1705</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889521.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1705"/>
    <dbReference type="EnsemblBacteria" id="CCC79007">
        <property type="protein sequence ID" value="CCC79007"/>
        <property type="gene ID" value="lp_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1705"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1441"/>
    <dbReference type="eggNOG" id="ENOG5032BP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219416_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1470-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="39" mass="4582" checksum="5A42FADE1F646688" modified="2011-10-19" version="1">MAKIKRQTPGFWGKLSLLIAIGQLGLTVFREVRQFKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA5</accession>
    <name>F9UPA5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transpeptidase-transglycosylase (Penicillin binding protein 1A)</fullName>
            <ecNumber evidence="11">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pbp1A</name>
        <name evidence="11" type="ordered locus">lp_1751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101535.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889558.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1751"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79044">
        <property type="protein sequence ID" value="CCC79044"/>
        <property type="gene ID" value="lp_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1751"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1477"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_5_9"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="PhylomeDB" id="F9UPA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1507-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="79"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="355"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="767"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="767" mass="83103" checksum="7A03A9313B3EAA40" modified="2011-10-19" version="1">MAGNNEQNSRVARRKSQPKPPKKHWFRRIILSLAALFVIGVLAGLALFFYYAQTAPTVKQSDLVNTGTAKIYDQNDKYLTSLGTNDHEYVKSSNIPSTLKNAVVSIEDRRFYKHKGVDYYRILGAAVGNLKGSSLGMQGGSTLTMQLVKLAVFSTSTSDRNLKVKAQEAWIALNLEKHYSKSQILEFYINKVYMGNGIYGMGTAAKYYYGKSLKDLSLSQLALLAGMPQSPTYYDPTTYPSYATSRRNLVLEAMYDNKVISKSQETAAEKVSVKTGLTSSGRSSLAKHEKTNKILDAYLNEVRQDLLKKGYNLTDGEKVYTNIDMDAQKRLYDIANTSQYVNYPNNGKQTFQLGVSVVDSYTGKVSAMIGGRKTGNVTYGTNRAVWTSRSNASTMKPILDYGPAIEYLNWPTYKSLSDTKYKYPGTNISVHDFDNNYLGNMTMREALVQSRNIPAIRALQAVGKSRAKTFANNLGMNLKTVNYANGIGAGVSTLQVAGAYAAFANGGVYHKPYYIRKVTTSDGVTTSYTSTGKRAMKKSTAYMITDMLKGVINSSTGTATTAKISGVYQAGKTGTDNYASQYKNKVPSDAVVDSWMAGYTKNYSVAVWTGYDKSTEAGGYLDTSNEKISQQIYRAMMNYLQQYSPNSDWTKPSSVGTTKKNGIEELYVVGHLFSSSEASSGTASSASSSSTTTGSSSTSTEASSRSSESSSSSSEAASSSSSAESSSSESSSESSSSSEASSSSEASSEATLSETPTADTNNTTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE9</accession>
    <name>F9UPE9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator subfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101557.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889602.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1803"/>
    <dbReference type="EnsemblBacteria" id="CCC79088">
        <property type="protein sequence ID" value="CCC79088"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="395" mass="43938" checksum="DD899EFE8A31A8FF" modified="2011-10-19" version="1">MLSPLTRRNLTLSYGYAACAFFGINTLWVIFLQQQGLSLVEIGLCESVFHLTSFLSEVPSGVIADRFGYRPVLIISRLMAIGHALIMLTAHSLGWLLLAFILQAWAYNLQSGTIEAAQYDSLVNTQATQHYPRVTTILNTTIEVADTLGVVLAGWLMPQHLSVTYWVYLAAALIAILAISGLHVPQRQLTKTHSTQPSLRTILRAAAHLLVTQRRLRLLMIFDALFSALGTTYYYYFQTVMTAQHFSGRLITTILIASMALNIVTIQLTPWLQRHQTQHQLLYGLCLSMIMALLSAFSHAIGLLVLIYLVINSLMALIEPLFSNYYNQLIPNGQRATLLSVASMVFSLAMISAFPLIGWLIQRVGFAVTFGSCGLLTLIALLSLYGYARRRAVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ3</accession>
    <name>F9UPJ3_LACPL</name>
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        <submittedName>
            <fullName evidence="9">Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily</fullName>
        </submittedName>
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    <gene>
        <name evidence="9" type="ordered locus">lp_1863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCC79132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640572.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889646.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1863"/>
    <dbReference type="EnsemblBacteria" id="CCC79132">
        <property type="protein sequence ID" value="CCC79132"/>
        <property type="gene ID" value="lp_1863"/>
    </dbReference>
    <dbReference type="GeneID" id="57025422"/>
    <dbReference type="KEGG" id="lpl:lp_1863"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1569"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_2_5_9"/>
    <dbReference type="OMA" id="IPGWVWR"/>
    <dbReference type="PhylomeDB" id="F9UPJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1594-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="62"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="9"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="491" mass="53561" checksum="063EB1F44FCABA40" modified="2011-10-19" version="1">MNRRAIYFVQGALLLSNVMAGIDSTNVNTALPAIIADLHGLRLMAWIVAVFLLGTAVSTLIWSKMGERFGNKRAYQMTTALFIVGSLLQGLAPNIWFLIIARGVAGLGNGGMISLPYIMYADIFKNPRDRMRALGLVSACFSMATIIGPMVGGVIVDVWSWHWIFYLNVPIGIVSAVLLQIFYQEPKREHNLQPMDRAGALLMAVGIISLLGGIELIGMVSLWIVAIVIVGALIVLGSLTIVERRAVDPVIPGRLFKNAPLVVDFVLFVLIWGAFVAFLTYSPMWAQGLLGTSALIGGATQIPSAFANFGGSESVPRMRRHLTPHRVLTINIIILTLTFVPLMIGGVKLPYWVLLLAGFFEGWGNGACFNELQVKVQVDADQRDIPVATSFSYLIRMLSQTFTTAIFGLIMNQALTSGVARSDGKITMAMMNQLSDASRAGRLPAHLVPMMRGILHTGLQNIMIVAFGLMIVALVINLWAQRHETQRQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ6</accession>
    <name>F9UPQ6_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Cell surface hydrolase, membrane-bound</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101600.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889709.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1935"/>
    <dbReference type="DNASU" id="1064091"/>
    <dbReference type="EnsemblBacteria" id="CCC79195">
        <property type="protein sequence ID" value="CCC79195"/>
        <property type="gene ID" value="lp_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1935"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1632"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_0_0_9"/>
    <dbReference type="OMA" id="IQFLWGK"/>
    <dbReference type="PhylomeDB" id="F9UPQ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1657-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388085" evidence="2">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="31679" checksum="BDF6C2F2D221F6CD" modified="2011-10-19" version="1">MKRIRLWGLMAGLLLLLVGCGRAETTGVTKPVTTQGHRYIPTLFFHGWGSSYHAETHMADAIVKAGKTQTIVRAMVAKNGTVTLKGHFRSGDYRPIVEVNFANNRSSDYPTVGRWAKNVVVALQRTYGITSFNMVGHSMGNMAITYYLLANAQNKRLPQLRQQVAIAGHFNGILGMDDSPNQMTLNAAGRPNKLRPAYRQLLGLRRVYPRQQVRVLNIYGDKGDGTHSDGSVSNASSRSLRYLVAARARSYREVKLTGKHAQHSQLHENAQVDRLLIDFLWPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPS6</accession>
    <name>F9UPS6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoin transport repressor, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645984.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1959"/>
    <dbReference type="EnsemblBacteria" id="CCC79215">
        <property type="protein sequence ID" value="CCC79215"/>
        <property type="gene ID" value="lp_1959"/>
    </dbReference>
    <dbReference type="GeneID" id="57025540"/>
    <dbReference type="KEGG" id="lpl:lp_1959"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1655"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_2_9"/>
    <dbReference type="OMA" id="ERDGWIY"/>
    <dbReference type="PhylomeDB" id="F9UPS6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1679-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="129" mass="14436" checksum="20AE77ABF8B2D400" modified="2011-10-19" version="1">MPFATNGAPYYEQLVMQIKQQIVQEVLRPGDQLPSIRAMASEMHLNPNTVSKAYQILEHQRAVYTVKGRGTFVSESSQIATDSNAVDDLQTRLQSLLTEAQFLGISAQQVQAWVTTAYQKGESRDEYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ89</accession>
    <name>F9UQ89_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malate/L-lactate/L-2-hydroxyisocapronate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101670.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2150"/>
    <dbReference type="EnsemblBacteria" id="CCC79378">
        <property type="protein sequence ID" value="CCC79378"/>
        <property type="gene ID" value="lp_2150"/>
    </dbReference>
    <dbReference type="GeneID" id="57025684"/>
    <dbReference type="KEGG" id="lpl:lp_2150"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077344_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UQ89"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1839-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="33165" checksum="36705AEF2790AA24" modified="2011-10-19" version="1">MINTVIIRGLFEFVQQLILVAIAKDLPVKLVVATGAEEAPRYQALVTASLTCRQFTLVAQAKPDYSQADSLIIGNLVPLASDRDASGDLKATLPLFRAFVNDAMGAGFNGKIILAGSNDAVLSVLAARFSGIDHSKVVGLGTLPQSRLLEQLLRQQLSVGPADVRAFVVGTAATHLISWSRSYIGPAPVMTYLANQDISFGMDEMSAATEQIDDPTIVTNQTLSVLALVQVLNAFYAQTPFIGTVTNIQTPVDDDQLVGLSSPVLISANGIKRMADMVLSDEEQKEYAEIASQVQEELDRVTAGELDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQC4</accession>
    <name>F9UQC4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsA</name>
        <name evidence="9" type="ordered locus">lp_2194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640855.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2194"/>
    <dbReference type="EnsemblBacteria" id="CCC79413">
        <property type="protein sequence ID" value="CCC79413"/>
        <property type="gene ID" value="lp_2194"/>
    </dbReference>
    <dbReference type="GeneID" id="57025722"/>
    <dbReference type="KEGG" id="lpl:lp_2194"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1854"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_1_1_9"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="PhylomeDB" id="F9UQC4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1874-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021873">
        <property type="entry name" value="FtsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11983">
        <property type="entry name" value="DUF3484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="8">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="448" mass="48325" checksum="6510AC2247BD268D" modified="2011-10-19" version="1">MDNSGIYVGLDIGTTSIKVIVAERVKGQMNVIGVGSARSNGLSRGVIVDIDKAAETIRSAVRQAEEKASIEIKKVIAGVPANLVKIERCRGMIAVADESKEINNEDVQNVAAAALVQSLPPEREVLDVIPDEFVVDGFDGIKDPRGMVGVRLEMHGTLFTGPKTIIHNTRKALEKAGLQIEQIVIAPLALSSLVLNDGEQDFGSIIIDMGGGQTTAAVIHDHQLKYTYVDQEGGQYITKDISVVLNTSIENAEKLKRDYGYADAQQASDDELFPVDVVGQSTPEQISEQYLAEIIEARLDQIFDKVKQHLDEIRALELPGGIVLTGGVAALPGITDLAAQRFGTRVRVFTPNQMGLRHPSFDEALAVIKYQAALSEVTLLVKSALTGDTRASVALEFADTTPAPSQPAAQPKKATKKQSAPQAPQEQADPDHKGTVERVKGFFNHFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD3</accession>
    <name>F9UQD3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF3397 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101682.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2205"/>
    <dbReference type="EnsemblBacteria" id="CCC79422">
        <property type="protein sequence ID" value="CCC79422"/>
        <property type="gene ID" value="lp_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2205"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1863"/>
    <dbReference type="eggNOG" id="ENOG503040A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161296_0_0_9"/>
    <dbReference type="OMA" id="MAFWITP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1883-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024515">
        <property type="entry name" value="DUF3397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11877">
        <property type="entry name" value="DUF3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="14098" checksum="25C351F36F6BDF87" modified="2011-10-19" version="1">MRDLWTTWYGQLVFLAAISMIILGAKRVAHRVWPHGLRLLDFWPPFLIVFTHFLTLQATDSSLAPYEVLSLMILGIGLTLIEAVERGEILYWRFFKLCWRGAELLTLVVYILALGSHFFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD7</accession>
    <name>F9UQD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101683.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889940.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2212"/>
    <dbReference type="DNASU" id="1061476"/>
    <dbReference type="EnsemblBacteria" id="CCC79426">
        <property type="protein sequence ID" value="CCC79426"/>
        <property type="gene ID" value="lp_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2212"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1868"/>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_3_2_9"/>
    <dbReference type="OMA" id="VDWTYLS"/>
    <dbReference type="PhylomeDB" id="F9UQD7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1887-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="23063" checksum="04543BAABF707A51" modified="2011-10-19" version="1">MKIMIIGATGMAGSAITKLALERNHTVVAIGRSEEKLAALPANPNLQTKAKDAFDLTLSELQAVDVVVDAMATSPDKAYRHVDLATKLIAQLREQQRPRLLFILGAGSLTTGDDQHLFVHDIESNPANAAFVAIPQNQLAELTFLRTVTNVDWVGISPATNFTAGPATPAQYGHDTLLTNTTGESVTNSGTMAVAVLNELETPKHHQERFTVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH0</accession>
    <name>F9UQH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bacterial type II secretion/trafficking system protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889973.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2248"/>
    <dbReference type="EnsemblBacteria" id="CCC79459">
        <property type="protein sequence ID" value="CCC79459"/>
        <property type="gene ID" value="lp_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2248"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1902"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_1_0_9"/>
    <dbReference type="OMA" id="TRQMATM"/>
    <dbReference type="PhylomeDB" id="F9UQH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1944-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="349" mass="39171" checksum="8F4692F12430E70F" modified="2011-10-19" version="1">MMNNWQRAVSIMRRPINLRKRKRLPIAMQAKLFETLADLLGNGFSFQQAFQFTLDVEGPAFQSLQPALGRLAAGDDLSMALRPYIAVDLYYQFLIAETHGELRRTLMQAGQLMRARAEQGRQIRRLLQYPCLLLILLLGTLGTVKAAILPSLAHGGNGSGTIANWQWFSGITVITLVICLLLVGLQVSRLPIRRRYQWLAQVPLIGPLIRNYCGYYLSLNAGMLLTGGLGIRGICEVSQHFQTKALIYQQGQVIEQALLTGTSLVTIIQEDRLLPDELALLVGKESPAEQLSQELLYFATLQYERLIRQLNRMIGWIQPIMFGIIALVVVGTYLSLLLPMYQSMGEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQJ8</accession>
    <name>F9UQJ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, DHH family</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ordered locus">lp_2279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101704.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890001.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2279"/>
    <dbReference type="EnsemblBacteria" id="CCC79487">
        <property type="protein sequence ID" value="CCC79487"/>
        <property type="gene ID" value="lp_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2279"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1929"/>
    <dbReference type="eggNOG" id="COG0618">
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    <dbReference type="HOGENOM" id="CLU_039720_1_0_9"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="PhylomeDB" id="F9UQJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1971-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="318" mass="34557" checksum="0681040BFCEA7184" modified="2011-10-19" version="1">MTVQTAIFDLIKQAKTIIIHRHQRPDPDAIGSQLGLAAIIKASFPAKRVLTPGKQYHGFDWLGQMDEVTEADYQDALVLILDTANQPRIDGELWNQGKTIVKIDHHPNDDAFGDPQWVDVDASSTSEMIYNWYAPLAAELTLTANAARLLYAGIVGDTGRFLYSATKPSTMRAAAALMEAGADAEAVNRIEDTITLPVARLSAYVYEHLTQLDSGAAYVILTNAILDSFAIGDASTAGVVPLPGRIDTVKCWAIFVQQKEGDFRIRLRSKGPSINGVAKNHDGGGHALASGAKAKDQQEIETVVRELDQVASQYEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQN3</accession>
    <name>F9UQN3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csd2</name>
        <name evidence="5" type="ordered locus">lp_2326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890036.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2326"/>
    <dbReference type="EnsemblBacteria" id="CCC79522">
        <property type="protein sequence ID" value="CCC79522"/>
        <property type="gene ID" value="lp_2326"/>
    </dbReference>
    <dbReference type="GeneID" id="57025859"/>
    <dbReference type="KEGG" id="lpl:lp_2326"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1967"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_9"/>
    <dbReference type="OMA" id="APHIINF"/>
    <dbReference type="PhylomeDB" id="F9UQN3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2006-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Cysteine_dSase"/>
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        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NifS"/>
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        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="2"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="42356" checksum="F11F18C1A8A1B857" modified="2011-10-19" version="1">MIYFDNSATTQAAPAVLETYTTVSQKIWGNPSSLHNFGETAFHLLEQSRQQIAGLLGVQAHEIFFTSGGTEGDNWVLKGTAIEKRAFGKHLITTAVEHPAIHNSMEQLKELGYEVTYLPVDQEGRINVADLKAAIRPDTILVSTMAVNNEIGTIQPLLEVAELLKQYPKIHFHIDAVQGIGKGIQNMIMNDRVDFVTFSGHKFHATRGVGFIYARNGRKLAPLMNGGGQESNWRSGTENLPAIAGMAKALRLLLTDEDGKVARERAIKQRIYEHIKSFPKVTIFSQPTTGFAPHILCFTINGVRGETIVHAFEDQGIYISTTSACSSKKHLASSTLMAMHVQENIATSAVRVSLDENNTLAEADQFIKVFDQLYQKFSKINADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQP3</accession>
    <name>F9UQP3_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="RefSeq" id="YP_004890046.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79532">
        <property type="protein sequence ID" value="CCC79532"/>
        <property type="gene ID" value="lp_2339"/>
    </dbReference>
    <dbReference type="GeneID" id="57025876"/>
    <dbReference type="KEGG" id="lpl:lp_2339"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="94" mass="10396" checksum="BE4371389CA058D5" modified="2011-10-19" version="1">MITLLLVIYTLIAGWLSYYLLTHQSRPFLFFDPNKAPTIKHVARYGGGLMLLVTIACFVTIFVQATMLIAIVLASGSLIMMAIALILVSFMQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY6</accession>
    <name>F9UQY6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 10, phage transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2447</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2447"/>
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        <property type="gene ID" value="lp_2447"/>
    </dbReference>
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    <dbReference type="OMA" id="NMTISHK"/>
    <dbReference type="PhylomeDB" id="F9UQY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2112-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="8523" checksum="BD377956226922FE" modified="2011-10-19" version="1">MILKLKYYREAMNLTQEELARHAKVSVAMVQSMENGRRKGSTDTILKLSDALNVTVDDLLRGNNMTISHKKETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQY8</accession>
    <name>F9UQY8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101779.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890141.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2449"/>
    <dbReference type="EnsemblBacteria" id="CCC79627">
        <property type="protein sequence ID" value="CCC79627"/>
        <property type="gene ID" value="lp_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2449"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122894_3_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2114-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="137" mass="15783" checksum="D425ACEA8F53CFF7" modified="2011-10-19" version="1">MDRVKDIVKTIVNRYHTADPFVIAEKLNIQVEWCDFGAMPLGKNAYDNQEPIILLNDSIKHTPTQYFILGHELGHVIFHEGLIGYYTSVKHGHSKFEREADEFSVGLMGMLFIEENGHIPYSYRELSYQYGVPFDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ8</accession>
    <name>F9UQZ8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 19, head-to-tail joining</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101788.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890151.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2462"/>
    <dbReference type="EnsemblBacteria" id="CCC79637">
        <property type="protein sequence ID" value="CCC79637"/>
        <property type="gene ID" value="lp_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2462"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2075"/>
    <dbReference type="eggNOG" id="ENOG502ZFJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085951_4_2_9"/>
    <dbReference type="OMA" id="LLTQFWY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2129-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08054">
        <property type="entry name" value="gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021146">
        <property type="entry name" value="Phafe_gp6_head-tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006450">
        <property type="entry name" value="Phage_HK022_Gp6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05135">
        <property type="entry name" value="Phage_connect_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01560">
        <property type="entry name" value="put_DNA_pack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="89" mass="10216" checksum="19C1CF0EB9730694" modified="2011-10-19" version="1">MAVTVDDIKLSLRIDVTEDDPMIKSYLDAAKDYVQTAVSKNEDLTIYKQYDFAVSLLTQFWYQNRVTDMTKTPYQVVSMIQQLRGLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR57</accession>
    <name>F9UR57_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 11">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hom1</name>
        <name evidence="15" type="ordered locus">lp_2535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101817.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890210.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2535"/>
    <dbReference type="DNASU" id="1062717"/>
    <dbReference type="EnsemblBacteria" id="CCC79696">
        <property type="protein sequence ID" value="CCC79696"/>
        <property type="gene ID" value="lp_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2535"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2132"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_9"/>
    <dbReference type="OMA" id="DWESEFF"/>
    <dbReference type="PhylomeDB" id="F9UR57"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2189-MON"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="13">
        <location>
            <begin position="139"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="426" mass="44825" checksum="BCF597FD4400AE16" modified="2011-10-19" version="1">MTTTIEVGMLGLGTVGSGVVERLTRSAAKIEQTQGIRLHLAAVAVNHLNAPRTVQLPIGTRLTDSLTNVVCDRKIQLVIEVMGTVATAKKAIVAALNQGKAVVTANKDLIATAGPELAALAKKQGCDLFYEASVAGGIPILRTLTDSYVTDNVQAVSGIINGTANYMLSAMATGQSYEQALATAQATGYAEADPTNDVAGIDAAYKLMILSRFAFGQELSLPQIAPTGITHLSASVCRLAAENGWQIKLLAQIQRHGSGLYCRVAPVAVPVDQPLSQINGVQNAVAVQSEAIGTSLYTGPGAGSTATANSVLNDVLVAAKHLINGYRMIRNQKRSVSLTVTRFDQLPQTYLGIGPVAPEAVKYYANEADFSVKTIADDCYQITGLSAVKRKKLRANLPLTLIPIAGTTDWKQVTENSITSPINVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE1</accession>
    <name>F9URE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system, N-acetylglucosamine-specific EIID component</fullName>
            <ecNumber evidence="10">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pts19D</name>
        <name evidence="10" type="ordered locus">lp_2648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890294.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2648"/>
    <dbReference type="EnsemblBacteria" id="CCC79780">
        <property type="protein sequence ID" value="CCC79780"/>
        <property type="gene ID" value="lp_2648"/>
    </dbReference>
    <dbReference type="GeneID" id="57026040"/>
    <dbReference type="KEGG" id="lpl:lp_2648"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2218"/>
    <dbReference type="eggNOG" id="COG3716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060742_1_0_9"/>
    <dbReference type="OMA" id="NIPYMAA"/>
    <dbReference type="PhylomeDB" id="F9URE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2271-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="29541" checksum="5C796A2D4BA8D92B" modified="2011-10-19" version="1">MASNSPISERGRLTKHDVRMLGWRSLFNQSAMNYERMQADGWTLAMLPSLRKIYGNDKEGLAAALESNLQFINTNNYAAPLLMGLEASLEEHGEKRSTIDGLRIALFGPLAGIGDAITWFTILPIVAGITASFAKQGSILGPLVFFLVYLAMFVARAPIALLGYNAGTKAISKIRENSGIVSHCASILGCTVIGGLIATYVQIAVKTKIPVSAGHTIAIQTQFFDRIFPNLLPLGYTFLLYWLLKKKNVSPVVLILGTFMLAILFSWMGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ7</accession>
    <name>F9URQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2008-10" db="PDB data bank">
            <title>Crystal structure of phosphoglycerate dehydrogenase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Bonanno J.B."/>
                <person name="Gilmore M."/>
                <person name="Bain K.T."/>
                <person name="Do J."/>
                <person name="Sampathkumar P."/>
                <person name="Wasserman S."/>
                <person name="Sauder J.M."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 4-316</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642534.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890410.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3EVT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=4-316"/>
    </dbReference>
    <dbReference type="PDBsum" id="3EVT"/>
    <dbReference type="SMR" id="F9URQ7"/>
    <dbReference type="STRING" id="220668.lp_2790"/>
    <dbReference type="EnsemblBacteria" id="CCC79896">
        <property type="protein sequence ID" value="CCC79896"/>
        <property type="gene ID" value="lp_2790"/>
    </dbReference>
    <dbReference type="GeneID" id="57026157"/>
    <dbReference type="KEGG" id="lpl:lp_2790"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2336"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_9"/>
    <dbReference type="OMA" id="WHHGTDK"/>
    <dbReference type="PhylomeDB" id="F9URQ7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2387-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="103"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3EVT"/>
        </source>
    </evidence>
    <sequence length="316" mass="34259" checksum="0CECA65DB9C89D66" modified="2011-10-19" version="1">MPMVLMAQATKPEQLQQLQTTYPDWTFKDAAAVTAADYDQIEVMYGNHPLLKTILARPTNQLKFVQVISAGVDYLPLKALQAAGVVVANTSGIHADAISESVLAAMLSVVRGYHAAWLNQRGARQWALPMTTSTLTGQQLLIYGTGQIGQSLAAKASALGMHVIGVNTTGHPADHFHETVAFTATADALATANFIVNALPLTPTTHHLFSTELFQQTKQQPMLINIGRGPAVDTTALMTALDHHQLSMAALDVTEPEPLPTDHPLWQRDDVLITPHISGQIAHFRATVFPIFAANFAQFVKDGTLVRNQVDLNRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV5</accession>
    <name>F9URV5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644760.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2853"/>
    <dbReference type="EnsemblBacteria" id="CCC79944">
        <property type="protein sequence ID" value="CCC79944"/>
        <property type="gene ID" value="lp_2853"/>
    </dbReference>
    <dbReference type="GeneID" id="57026209"/>
    <dbReference type="GeneID" id="66450485"/>
    <dbReference type="KEGG" id="lpl:lp_2853"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2386"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_2_0_9"/>
    <dbReference type="OMA" id="NVTFTPC"/>
    <dbReference type="PhylomeDB" id="F9URV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2441-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="132" mass="14650" checksum="A35458319A1F72AA" modified="2011-10-19" version="1">MTTTNNSGLFGLGVKNEAYQQYFIGQSYLNALAGDEQVDVNVSNVTFEPGCRNNWHIHHNGYQILLVTSGEGWYQEAGKPAQLLHPGDVVTIHPGVKHWHGATKDSWFAHIAITKGTSEWLEPVDDEAYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW3</accession>
    <name>F9URW3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sip1</name>
        <name evidence="8" type="ordered locus">lp_2862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890466.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2862"/>
    <dbReference type="DNASU" id="1063232"/>
    <dbReference type="EnsemblBacteria" id="CCC79952">
        <property type="protein sequence ID" value="CCC79952"/>
        <property type="gene ID" value="lp_2862"/>
    </dbReference>
    <dbReference type="GeneID" id="57026216"/>
    <dbReference type="KEGG" id="lpl:lp_2862"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2395"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_0_9"/>
    <dbReference type="OMA" id="IEPRWIP"/>
    <dbReference type="PhylomeDB" id="F9URW3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2449-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="205" mass="23316" checksum="B288719AADF229B4" modified="2011-10-19" version="1">MKTFKSIMSWVVPIAIGLIIALLIRQFWFTMVKVDGTSMQPNLQNNERVVAFKTSKIKAGSVVVFNAYGLDPNQTDKNAVYVKRVIGMPGDTVRYTSSGKLYVNNKLVKQTYLKNKYQQTTGSFMANSHSKFTGWTLNSLSHDQGWAKSVTNNTVPKGYYFVLGDHRSVSNDGRYWGLVPKSKMIGVVKAWPWQNRKQYINNYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX9</accession>
    <name>F9URX9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101949.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79968">
        <property type="protein sequence ID" value="CCC79968"/>
        <property type="gene ID" value="lp_2880"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2880"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2411"/>
    <dbReference type="eggNOG" id="ENOG5030BK2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1523283_0_0_9"/>
    <dbReference type="OMA" id="SHIKECI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2465-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="171" mass="19607" checksum="A47E5BC7E2E56CBB" modified="2011-10-19" version="1">MRALVEVNQNKINIELDDLAKLIWGIDKNGLWINHAGTTQTLKDEFRLSFSLFPSDLNPEWQNVPLEWKADGLLIQPAKENSKKVAVFTEFETELPFNQKGFYNLVAYLATHLNGKISEDDGNRWEPVAQFRAKHKSIMTADFDQLLSESIKIGPNISPVDEPKYYDLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA6</accession>
    <name>F9USA6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890550.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2974"/>
    <dbReference type="EnsemblBacteria" id="CCC80036">
        <property type="protein sequence ID" value="CCC80036"/>
        <property type="gene ID" value="lp_2974"/>
    </dbReference>
    <dbReference type="GeneID" id="57026308"/>
    <dbReference type="KEGG" id="lpl:lp_2974"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2481"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_1_0_9"/>
    <dbReference type="OMA" id="HTNQEMA"/>
    <dbReference type="PhylomeDB" id="F9USA6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2532-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394314" evidence="1">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="321" mass="33847" checksum="B495F5D5C4C3583B" modified="2011-10-19" version="1">MKKTTLGVLILGAGLLLAGCGKQATSGQQSVSVGILQVVQHGSLDQARKGFKAGLQKELKAHNSKVTVKYHYLNAQGDQSNLNTMSQQLVQQKNDLLVGIATPAAQALAKKTTTVPTLVTAVTDLKAAGLVKSDTKPQTNVSGTSDLMPVGKQLQLLKNMSTGNKPLGIMYNSSEENSVLQVKLAKAYAKKHGINLKVVSATSTNDVASVLAGLTGKISGLYLPTDNLMASAMKTIGQKTKAAKLPVVTGSIEMAEDGGTATYGLNYYELGEQTGKMAYQVLIKKQKPQTMAVQTADKLHLYVNKANAKAIGLQPSTIKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB6</accession>
    <name>F9USB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter,permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livB</name>
        <name evidence="7" type="ordered locus">lp_2984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890560.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2984"/>
    <dbReference type="EnsemblBacteria" id="CCC80046">
        <property type="protein sequence ID" value="CCC80046"/>
        <property type="gene ID" value="lp_2984"/>
    </dbReference>
    <dbReference type="GeneID" id="66450584"/>
    <dbReference type="KEGG" id="lpl:lp_2984"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2491"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_9"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="PhylomeDB" id="F9USB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2541-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="31067" checksum="E9F93C90DC04A727" modified="2011-10-19" version="1">MQTFGQQLINGLSLGSIYALLALGYTMVYGIIKLINFAHGDIYMLGAFWGYYSLKSLHFNFVAALLSAMVICAVSGVIIEYFAYRPLRHSPRITALITAIGVSFLLENGMSYFVGASARSFPQAIKVVTYHWGGLRVSNVQLLILGTACLLMILLELIIKRTKMGKAMRAVSVDPEAAQLVGINLNHTISFTFALGSAMAGAAGVLIGLYYNSIDPLMGMTPGIKAFVAAVIGGIGSVPGASLGGFIIGILETGVQAIGLSAYKDAVVYFVLIVILLVLPAGIFGKRTKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USF1</accession>
    <name>F9USF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102012.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890595.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3024"/>
    <dbReference type="EnsemblBacteria" id="CCC80081">
        <property type="protein sequence ID" value="CCC80081"/>
        <property type="gene ID" value="lp_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3024"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2527"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_13_0_9"/>
    <dbReference type="OMA" id="PHATIHD"/>
    <dbReference type="PhylomeDB" id="F9USF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2575-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="303" mass="34127" checksum="C9D885AF26F4BAD8" modified="2011-10-19" version="1">MDFNQLQTFLRVSEYGSFTKAGEQSFISGTAVMKQINRLEAELNLKLFVRTATGVQLTPQGKKFQPYVQQLLDLLNTAIEETRRVRSDDKQLILLGTSLLHPADAFMSLWKELAPKMPKFQIRLVQLQEDLNSRNREYAMLGRSSDLIVGTFDSTTLKQSFSAIQLGAYHFGIAVRSDNPLAQLDEITYSDLAHRKVLMVSTGISEKNDLVRSEMLAAEPSIQPIDTSGRYDINTFNETVEENIAMISLTPWKRIHPNLVTVPLKTSVTVPYGLLSTKFPGKKTADFLHEFTKLVPTETQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM2</accession>
    <name>F9USM2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, subgroup 7</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890666.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3108"/>
    <dbReference type="DNASU" id="1063753"/>
    <dbReference type="EnsemblBacteria" id="CCC80152">
        <property type="protein sequence ID" value="CCC80152"/>
        <property type="gene ID" value="lp_3108"/>
    </dbReference>
    <dbReference type="GeneID" id="57026418"/>
    <dbReference type="KEGG" id="lpl:lp_3108"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2598"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_9"/>
    <dbReference type="OMA" id="RFAENCE"/>
    <dbReference type="PhylomeDB" id="F9USM2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2645-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="32397" checksum="6B8CCFF05F82BAA7" modified="2011-10-19" version="1">MKVFITGGTGFVGSAVVQELVANGFEVVGLARSETSAQKLISWGAQPVRGSLTSLSTLATAAAQADAIIHLGFNNDFRHFFQAGAMDRRAIETMGRAISGTNKPLVVTYGTTGIRKHVETEHEVADTGLLKWLTPRKSEIVARQLMAQNINAFVVRLSPAVHGAGDMGFTRTVIERAKKSHRAEYFGLGTHAWSAVHRLDAAHLFYLVTMYGLEHPTTNERVFNAVAEESITIAAIARTISRKLNVPLKAKYNPLSFGDTAMLYLINCPTSSQLTRQILGWVPVQPDLLTDISSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY0</accession>
    <name>F9USY0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone phosphotransferase,dihydroxyacetone binding subunit</fullName>
            <ecNumber evidence="2">2.7.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dak1B</name>
        <name evidence="2" type="ordered locus">lp_0168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.29" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0168"/>
    <dbReference type="EnsemblBacteria" id="CCC77711">
        <property type="protein sequence ID" value="CCC77711"/>
        <property type="gene ID" value="lp_0168"/>
    </dbReference>
    <dbReference type="GeneID" id="57026998"/>
    <dbReference type="KEGG" id="lpl:lp_0168"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.136"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_0_9"/>
    <dbReference type="OMA" id="MLSAACP"/>
    <dbReference type="PhylomeDB" id="F9USY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-133-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="332" mass="36104" checksum="ED49CB8FD11A8D6D" modified="2011-10-19" version="1">MKKIINDPKNVVDEMVDGLVRAYPQYLTKLPDTEAMVRSDQDSMQGKVGIVSGGGSGHEPAHAGFVGPGMLSAAVAGQVFTSPTPDQIYAAIKAVDQGKGVFLVVKNYSGDVMNFDMAKDMAELDDIQVKSIVVDDDIAVKDSLYTQGRRGVAGTIFMHKILGAAADQGVDLDDLESLATHVLPRIKTIAVALSAATVPEVGKPGFELADDEIEFGVGIHSEPGYRREKIKPSKQLVQELLGKLDDELHLQSDHQYAFLVNGMGATPLMDQYVFCHDLLDELATRHIQPAFMKVGNYMTSIDMAGISLTIFDVAESQWLDYLQYPVKTIAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT04</accession>
    <name>F9UT04_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643688.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0194"/>
    <dbReference type="EnsemblBacteria" id="CCC77735">
        <property type="protein sequence ID" value="CCC77735"/>
        <property type="gene ID" value="lp_0194"/>
    </dbReference>
    <dbReference type="GeneID" id="57027022"/>
    <dbReference type="KEGG" id="lpl:lp_0194"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.160"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="KQGRNIM"/>
    <dbReference type="PhylomeDB" id="F9UT04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-157-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="34100" checksum="30C3DE02F637D61E" modified="2011-10-19" version="1">MNIKDLYYFQRLISTQSYTQTAADFHVSQPTISQAIKRLERHFQVTLFFRQAKTKALVLTPSGQQLLLAANDIINNWQHVNESISHLRQHTLRFGIEPSVSEHYLPALTKPIIEQDLLSSVHTVEMGANQLVKQVLAGQLDLAISGNLDQTLDERLAVTPLRPFKFRILANVAHPLAKAEHPTFAEALKSPFVLLNATYLNKLVFRQLAEQLSIEPQVLFESDSSTLIKGLVKENLALGFISDITTPNDGEDDGLVEIPFDDVQVPSVHINLIRRAHQFPIGLVKQVIDIIEKTFAADNAEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT26</accession>
    <name>F9UT26_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5 diketo-D-gluconic acid-like reductase,NADP dependent (Promiscuous)</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77757">
        <property type="protein sequence ID" value="CCC77757"/>
        <property type="gene ID" value="lp_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0221"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.184"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="OMA" id="WPPFLYD"/>
    <dbReference type="PhylomeDB" id="F9UT26"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-179-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="14"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="276" mass="31233" checksum="98082736862C8B8B" modified="2011-10-19" version="1">METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRRSSVPRSELLISSKLPGRHHTYTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQVELHPYFNQQAQRDYDQAHGILTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNMDVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT29</accession>
    <name>F9UT29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, Cro/CI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888274.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0225"/>
    <dbReference type="EnsemblBacteria" id="CCC77760">
        <property type="protein sequence ID" value="CCC77760"/>
        <property type="gene ID" value="lp_0225"/>
    </dbReference>
    <dbReference type="GeneID" id="57027047"/>
    <dbReference type="KEGG" id="lpl:lp_0225"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.187"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_4_9"/>
    <dbReference type="OMA" id="TLNDIFW"/>
    <dbReference type="PhylomeDB" id="F9UT29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-182-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7554" checksum="7605DEC910E2798D" modified="2011-10-19" version="1">MLTANHVKQYRLMAGFSQKELASKTGITRQTLSLIEKGTYNPSLKLCLNLCHALNQTLDTVFWVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT40</accession>
    <name>F9UT40_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
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    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888285.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77771">
        <property type="protein sequence ID" value="CCC77771"/>
        <property type="gene ID" value="lp_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0240"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.198"/>
    <dbReference type="eggNOG" id="ENOG50309XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1904054_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-193-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="133" mass="15022" checksum="30E1A8C39BDBEDA8" modified="2011-10-19" version="1">MNIVVGPYVRRPRAVKSDPRNTSKFSMFNSLRRIDECLVLIKRTGTPGLIDSTATLGLNLTHLMGLNVIVTSRGRSFTIIVQGRQRSFTLTGCLIEDTLYNAVHPAQPDYLISLNRQLITNSDDLIEQLYDHY</sequence>
</entry>
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    <accession>F9UT54</accession>
    <name>F9UT54_LACPL</name>
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            <fullName evidence="4">Cystathionine beta-synthase</fullName>
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    <gene>
        <name evidence="4" type="primary">cbs</name>
        <name evidence="4" type="ordered locus">lp_0256</name>
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        <lineage>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="4">
        <citation type="journal article" date="2017" name="Protein Sci." volume="26" first="763" last="783">
            <title>Crystallographic and mutational analyses of cystathionine beta-synthase in the H&lt;sub&gt;2&lt;/sub&gt; S-synthetic gene cluster in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Matoba Y."/>
                <person name="Yoshida T."/>
                <person name="Izuhara-Kihara H."/>
                <person name="Noda M."/>
                <person name="Sugiyama M."/>
            </authorList>
            <dbReference type="PubMed" id="28127810"/>
            <dbReference type="DOI" id="10.1002/pro.3123"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888299.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="5B1H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B/C/D=1-303"/>
    </dbReference>
    <dbReference type="PDB" id="5B1I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-303"/>
    </dbReference>
    <dbReference type="PDBsum" id="5B1H"/>
    <dbReference type="PDBsum" id="5B1I"/>
    <dbReference type="SMR" id="F9UT54"/>
    <dbReference type="STRING" id="220668.lp_0256"/>
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        <property type="protein sequence ID" value="CCC77785"/>
        <property type="gene ID" value="lp_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0256"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.212"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_9"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="PhylomeDB" id="F9UT54"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-207-MON"/>
    <dbReference type="BRENDA" id="2.5.1.47">
        <property type="organism ID" value="2849"/>
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    <dbReference type="BRENDA" id="4.2.1.22">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:cysteine biosynthetic process from serine"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="P-phosphate_BS"/>
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        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
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        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5B1H"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5B1I"/>
        </source>
    </evidence>
    <sequence length="303" mass="32204" checksum="DAE3B8D34791E5B4" modified="2011-10-19" version="1">MLIQHVQELIGHTPLMALPIEVPNHSHIYAKLEMFNPGGSIKDRLGAYLIEDGLQRGRVNAKTTIIEPTAGNTGIGLALATQAHHLRTILVVPEKFSMEKQVLMQALGAEIVHTPSEEGIKGAIRKAEALAATISNSYVPMQFKNPANPAAYYHTLAPEILADMPAPITAFVAGAGSGGTFAGVAAYLQAQDSATKAVVVEPEGSILNGGPAHAHRTEGIGVEFIPPFFDQVRIDQTLTIADNDAFAQVRHLARDHGLLIGSSSGAALAASLQLATNLPANSHIVTIFPDSSERYLSQKIYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT59</accession>
    <name>F9UT59_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Trehalose operon transcriptional repressor,GntR family</fullName>
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        <name evidence="2" type="ordered locus">lp_0262</name>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888304.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_0262"/>
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        <property type="gene ID" value="lp_0262"/>
    </dbReference>
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    <dbReference type="GeneID" id="66448358"/>
    <dbReference type="KEGG" id="lpl:lp_0262"/>
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    <dbReference type="OMA" id="HRPDKFR"/>
    <dbReference type="PhylomeDB" id="F9UT59"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-212-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
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        <property type="entry name" value="TreR"/>
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    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02404">
        <property type="entry name" value="trehalos_R_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="239" mass="26899" checksum="C2F26E8E5A5915E9" modified="2011-10-19" version="1">MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIRGKGSIVIEHRQYEFPVSGIVSYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTEAPVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDSLYAYFENQLGLTIGYATKEITMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT70</accession>
    <name>F9UT70_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall hydrolase/muramidase, C-terminal</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acm3-C</name>
        <name evidence="2" type="ordered locus">lp_3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3154"/>
    <dbReference type="EnsemblBacteria" id="CCC80188">
        <property type="protein sequence ID" value="CCC80188"/>
        <property type="gene ID" value="lp_3154"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3154"/>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052817_1_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08460">
        <property type="entry name" value="SH3_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="154" mass="16595" checksum="A7832EB7BD29FDA3" modified="2011-10-19" version="1">MPSTISIPSTSTYTPTNPMRNVSGTYTFTENTNIRTAPSLSAPVVGTYYPGDSVTYTGQVNAEGYIWLQYLSGSGNTRYVAMSGTSAQYNTNNISGTFTFTQQTNIRTAPSTSASIVGVYYPGDSVIYNAQITADGYTWLQYISGSGTLRYAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT76</accession>
    <name>F9UT76_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_3160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890708.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3160"/>
    <dbReference type="EnsemblBacteria" id="CCC80194">
        <property type="protein sequence ID" value="CCC80194"/>
        <property type="gene ID" value="lp_3160"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3160"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2642"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_2_5_9"/>
    <dbReference type="OMA" id="MYNFPTW"/>
    <dbReference type="PhylomeDB" id="F9UT76"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2684-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="9"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="52867" checksum="32F3738954910C9B" modified="2011-10-19" version="1">MTKRRMAIATIALLIANFMGGLDATIVNTALPAITSDLNGIRLIGWISSIFLLGTAVTTVLWGRVGELIGNKLTFQISVVLFIISSVVGGLSTNMVMLIIARAFMGIGAGGMVSIPFIIYADLYENPAERARALGWVTAFYTLSTVVGPLIGGWLVDTLSWHWVFFINLPIGIISLLLLQFSYRESEHEATQKRFDYLGSGLLIVTLIVLLFASDAIAPNLTQALVLLVIGLILMVIFYQVEKRQKNALVPTELLKNWRIQSQNVIMFLINGFFIGYSVYAPMWSQGLLGTSATLGGLTQIAGSILLLVGTRYTAHLMVKMPYKRIVMFGILSVLLSALSMVMATQFAPYWWLLVSGGFNGLGMGLSFTPMQVSLQDGVRRDLISVSTTFGLLFRTLGQTFMSSIFGAILSISTASQIGGKITTQMINKLTDASSARSLPQNLLPQLRTILFNGMHLIMVIGLILVVIAFVINLTRKEPAKQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT80</accession>
    <name>F9UT80_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
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                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
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                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890802.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3280"/>
    <dbReference type="EnsemblBacteria" id="CCC80288">
        <property type="protein sequence ID" value="CCC80288"/>
        <property type="gene ID" value="lp_3280"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3280"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2737"/>
    <dbReference type="eggNOG" id="COG0053">
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    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="PhylomeDB" id="F9UTH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2776-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
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    </dbReference>
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        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="239"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="34466" checksum="725F61D388E02156" modified="2011-10-19" version="1">MLDGWQEIEADQIKRMQSALWHLLGNAIAYLSLFVIELVLATIGHSQSLHADAFNNFAGIVSSGLLSLGIWGGIHNHQSHQSKVTALDGWEAERRNRLMRFRLQDLFTLMSGVIMLVMAVQVIVSGVSNLFKSHTVQAVSGVTVWGAAIASIVMLVVWYFNRRGGQQLDNSTLLAAAKDSLSDALTSIGTLISLSGVLLFKFAWLDSVASIVIGFFIFAAGLQIFRDSGLQLINYSDPQVEKNYINTIQQIDGVNQVNAIDVQYSGSLVALSLVIAVSPRMTVAASFQLSERIEQVMRNQYGIIDTKVMFMPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTP6</accession>
    <name>F9UTP6_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Glycolate dehydrogenase, subunit GlcD,FAD-binding</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glcD</name>
        <name evidence="4" type="ordered locus">lp_0291</name>
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    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.3.15" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100951.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888330.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0291"/>
    <dbReference type="EnsemblBacteria" id="CCC77816">
        <property type="protein sequence ID" value="CCC77816"/>
        <property type="gene ID" value="lp_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="57027103"/>
    <dbReference type="KEGG" id="lpl:lp_0291"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.244"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_1_9"/>
    <dbReference type="OMA" id="CNDNMLA"/>
    <dbReference type="PhylomeDB" id="F9UTP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-238-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
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        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="464" mass="50221" checksum="703F7527BCFC5DA5" modified="2011-12-14" version="1">MTVFRAFSNQEVLDYLATQVTDGQVFTDEETLKKYSFSPRLTDDDSGLALAYVEAHTTKDIQGTLKTARKYHIAVIPQDQTTSTVIGADGLTDSLILSTAKMNRIIEISKADSIAVVEPGVVNGDLDKEARKQGMFYAPDPGSKPISGIGGNVATNAGGMSTVKYGATKDNVLGVKVVLADGREVKLGGRTLKQAFGYDLTQLMIGSEGTLGIITEVIVKLLPIPLGTPVMGVAFFDNMTALAKAVTAIRISGVYPTMLEALDGNTVAALDRYEKTHYAKNSAAMLIFKLDNGGQDSMAVVKKILAEQQANDVKITTEPKEQAALEQLRRDMLPAVFAGQNHIMEDMAVPLSQLAPLMDYIQELSKRLDVEIYTAGHAGDGNVHPTLVWPTSVTEVPEKIIIALQEMFKKTLALGGTISGEHAVGMLKNQWNNAELGEDVDMLQHQIKALFDPMNILNPKRKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT4</accession>
    <name>F9UTT4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888368.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0332"/>
    <dbReference type="EnsemblBacteria" id="CCC77854">
        <property type="protein sequence ID" value="CCC77854"/>
        <property type="gene ID" value="lp_0332"/>
    </dbReference>
    <dbReference type="GeneID" id="57027145"/>
    <dbReference type="GeneID" id="66448426"/>
    <dbReference type="KEGG" id="lpl:lp_0332"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.282"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_9"/>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="PhylomeDB" id="F9UTT4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-276-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="32507" checksum="44100F2D49A2D906" modified="2011-10-19" version="1">MVGIIVAIIVILLVVLVLIASIRIITQPNQGVVLTFGKFERVISSGFHFIKPFISRVITVNTAQTPVDLNQQVVITKDNAEISVKISLKYHVTNIEDFVFKNEDSVRSMIQDTRAALRGIIGNKELNEVLNGTQEINAALFKEISSVTAGYGLNVDRVNIDSVNPSADIQASMNKLLQATRERDATIATAEGKSKSITLENEANNRALLATNKAQNEALVNSAKAKATAVQTEADADAYRTRILNEALAQSSENYFIFQNTEAVKALADGNANTVVLPNQTLDSLGLIPALTKVSKLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTU8</accession>
    <name>F9UTU8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amtB</name>
        <name evidence="10" type="ordered locus">lp_0349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0349"/>
    <dbReference type="EnsemblBacteria" id="CCC77868">
        <property type="protein sequence ID" value="CCC77868"/>
        <property type="gene ID" value="lp_0349"/>
    </dbReference>
    <dbReference type="GeneID" id="57027159"/>
    <dbReference type="KEGG" id="lpl:lp_0349"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.296"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_9"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="PhylomeDB" id="F9UTU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-290-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="8"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC77868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="438" mass="47721" checksum="828AAB68E9B22B10" modified="2011-10-19" version="1">MNAANSTFLVLSSILVLFMTPGLAFFYGGLVSKRNVVNTMLSVFMICGLAILLWLAFGYSLSFSGDLGGFVGNLKATWLHGVDLTALTATKIPNGLYLIFQMMFAIITPALFVGAVVGRIRFKFLLTFIIFWSLLIYYPMVHMVWDNGLLAKLGVIDFAGGTVVHINAGITALVLSAFLGARHKYGKDMTQHYNILWVLLGTAILWIGWYGFNAGSALAMNDIAIQAFLTTTVATATSMMTWMVVDMLTKGKPTLVGVCTGTLCGLVAITPACGYVTISGAFWIGLIATLTSYGFITFIKPRLGIDDALDAFGCHGVSGMVGSIMTGLFASKAVNRTISLNGLFYGGGFKLFGLQLLATIFTIGFTTIVCIVIIVLLKRVIRMRVDEREEELGLDQGEHGEVADYTVQMSHDLTNIQHHSDEFRGQLAQLLDKQQRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX7</accession>
    <name>F9UTX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100988.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888411.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0382"/>
    <dbReference type="EnsemblBacteria" id="CCC77897">
        <property type="protein sequence ID" value="CCC77897"/>
        <property type="gene ID" value="lp_0382"/>
    </dbReference>
    <dbReference type="GeneID" id="57024196"/>
    <dbReference type="KEGG" id="lpl:lp_0382"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.322"/>
    <dbReference type="eggNOG" id="ENOG5030BHD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187595_0_0_9"/>
    <dbReference type="OMA" id="TTQNTTH"/>
    <dbReference type="PhylomeDB" id="F9UTX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-319-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="87" mass="9556" checksum="7631426D8AD7075A" modified="2011-10-19" version="1">MATIIIIGVVIIGITLGLGFWSYLLGKRNQSNFVGTIIPIAYFVVRTVLVVTTQNTTHGLVSSLVGSLLFSLVYYGLFAWGKYRTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ3</accession>
    <name>F9UTZ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin immunity protein PlnL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnL</name>
        <name evidence="2" type="ordered locus">lp_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888427.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0404"/>
    <dbReference type="EnsemblBacteria" id="CCC77913">
        <property type="protein sequence ID" value="CCC77913"/>
        <property type="gene ID" value="lp_0404"/>
    </dbReference>
    <dbReference type="GeneID" id="57024211"/>
    <dbReference type="KEGG" id="lpl:lp_0404"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.333"/>
    <dbReference type="eggNOG" id="ENOG5030AMI">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106313_0_0_9"/>
    <dbReference type="OMA" id="LPLTWIW"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-336-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="25205" checksum="783009F7F17974BA" modified="2011-10-19" version="1">MIEIDFKEKYYPLVLVLFVAGYMGAIFLNIYFDWLAMLTAGIISLVMLYGFSNLKLFFQPLPSPKWRIVVKYVLLLLVLEVTAIVVIAIINSHALLSFHNTTLTTSSTGRDYPLIERVWIAFTLLVSLVGEEVGMASISLPLIRLLSQTQLKKYAWPIINVLGCIVFACLHLPHYHFNWIYPLIVGITRYPITASWRSANTLRSGIYVHWISDAVLIIGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU13</accession>
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        </submittedName>
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        <name evidence="3" type="ordered locus">lp_0426</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888447.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0426"/>
    <dbReference type="EnsemblBacteria" id="CCC77933">
        <property type="protein sequence ID" value="CCC77933"/>
        <property type="gene ID" value="lp_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="57024228"/>
    <dbReference type="KEGG" id="lpl:lp_0426"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.347"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108439_0_0_9"/>
    <dbReference type="OMA" id="QSENDKM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-354-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24538" checksum="DE4D399B33EF64AA" modified="2011-12-14" version="1">MVARLIRVFGYVLAGLGLFIFIQLPVLADGYWNWWGERPQQINIGYHWVALVVLTVGVAVVLVRCYHHYFEMPVLLGPFSWSMMGLTALVAVVVVVIQMGISGLLVSPTETQNDEIMALIHSPLGLLTLVCTNIVSPVLEELLFRGIVQNTLRRYLPVLGAIILTNAVFALGHGYQLASTVGIFITGCGFSWLVLKTKQLSTAMGCHILVNWLVTLINMMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU66</accession>
    <name>F9UU66_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P3 protein 7, DNA replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102136.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890882.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3383"/>
    <dbReference type="EnsemblBacteria" id="CCC80368">
        <property type="protein sequence ID" value="CCC80368"/>
        <property type="gene ID" value="lp_3383"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3383"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2819"/>
    <dbReference type="eggNOG" id="COG3378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082084_0_0_9"/>
    <dbReference type="OMA" id="HELRLIW"/>
    <dbReference type="PhylomeDB" id="F9UU66"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2856-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08708">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PriCT_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="259" mass="28794" checksum="5F7341146B6D7910" modified="2011-10-19" version="1">MKANDRLMRALQLARDGVAVYPLASNSKVPLKGTQGYKDATTDVEKIKGWFEHVPGANLGIRLDQVKLLVVDVDRHGDIDGVQTLKRLNEHGKTLPSDTYIEQTPNDGLHYLFKLPDKLDMKRRTGLYPGIDVLADFVLVAPSVINGSAYRAIEPTNEITTAPQWLIDDLLPSQRMNKAPQPASQIRKTWAGRMLDDLVAGTGEGSRNSYLTSLLGKLLRTGCNGMTAYELLQYANERLQPPLPDKEVNTIFKSIIKRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB3</accession>
    <name>GLPF5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol uptake facilitator protein-like 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glpF5</name>
        <name evidence="6" type="ordered locus">lp_3436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890929.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UUB3"/>
    <dbReference type="SMR" id="F9UUB3"/>
    <dbReference type="STRING" id="220668.lp_3436"/>
    <dbReference type="EnsemblBacteria" id="CCC80415">
        <property type="protein sequence ID" value="CCC80415"/>
        <property type="gene ID" value="lp_3436"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3436"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2863"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_9"/>
    <dbReference type="OMA" id="ACFPGRK"/>
    <dbReference type="PhylomeDB" id="F9UUB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2903-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441646" description="Glycerol uptake facilitator protein-like 5">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="5">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="26557" checksum="58EC35972E1073FA" modified="2011-10-19" version="1">MTGSWEARYAAEFFGTLILVLLGNGAVANAFLKNTTGNDDPGLANGGWLLVASGYGLGVMLPAMMFGSISGNHLNPAITIGQAVIGIFPWAHVAPYLIWQFLGAIAGQCLILALYWPHYRQTTDNEAVLGTFATSDHANSQLNGFVTEMVGTAVLIFGAMGLYRGMFFHQNIDIANIGVGLLIAAMVISLGGPTGPALNPARDLGPRLVHALFPVPNKGSSHWEYSWVPVVAPIVGAVIGIWIYKIFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC6</accession>
    <name>F9UUC6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643037.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3453"/>
    <dbReference type="EnsemblBacteria" id="CCC80428">
        <property type="protein sequence ID" value="CCC80428"/>
        <property type="gene ID" value="lp_3453"/>
    </dbReference>
    <dbReference type="GeneID" id="57026674"/>
    <dbReference type="KEGG" id="lpl:lp_3453"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2876"/>
    <dbReference type="eggNOG" id="ENOG5032QCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_5_2_9"/>
    <dbReference type="OMA" id="GAPAIMS"/>
    <dbReference type="PhylomeDB" id="F9UUC6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2916-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389054" evidence="1">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="39"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="190" mass="20088" checksum="CAEB806E175452F6" modified="2011-10-19" version="1">MKKYLGTLVAGMTLMAGLPLVGQAADTETTTKAEVELIQDDTNKDITLDQAPGVSFGTEKITNDSKTYDAKNVTGDLKVTNPGNTDGWLVQVKGSKFMNADDTRELRGAALTFAQVNATADDANNISKAKAYKVDITDQNQIIMDAEANEGIGKFTSKYATNEVSLLIPAGNAAGAYTSTLTWTLGNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG9</accession>
    <name>F9UUG9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shikimate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_3503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890985.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3503"/>
    <dbReference type="EnsemblBacteria" id="CCC80471">
        <property type="protein sequence ID" value="CCC80471"/>
        <property type="gene ID" value="lp_3503"/>
    </dbReference>
    <dbReference type="GeneID" id="57026716"/>
    <dbReference type="KEGG" id="lpl:lp_3503"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2919"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045105_0_1_9"/>
    <dbReference type="OMA" id="FWTAQCV"/>
    <dbReference type="PhylomeDB" id="F9UUG9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2959-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="9"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="42795" checksum="A96A2F6418467D12" modified="2011-10-19" version="1">MKHKTYLPLAAGIYLNYAILGMATIIVSQYGTQFQALWHTDVKGLSTVIAMIGIGRLLTILIAGYLSDRLGRKGTMLIGMVAQILFLMGLFFSTNLISACIAALFMGATNSFGDTASYPALTDAFQEQAASMNSLVKAAMSLAQFVLPFIVAAQPNAQITLVVMVVVMVLDIILIGLASFAPQTLTQKHTKISDEPKTTINPSGNQPSMLIDGSLLIIVGFTLSFTFYIFSQYAPNFGSSVLKLGLNSSKSLISWYAMASLVSVFITSSLVTRIKPIKLIFAYTLISFLALLQMVVIPSADGARLTAIAIGFFAAGGIWQLGLTLLSQYFPAEKGKVTGYYSFATALTFFVGPLVSSFIIDDTAVSVLHVFEIDTGVTLLSLVIVIILMIRNRKFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI8</accession>
    <name>F9UUI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102203.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3524"/>
    <dbReference type="EnsemblBacteria" id="CCC80490">
        <property type="protein sequence ID" value="CCC80490"/>
        <property type="gene ID" value="lp_3524"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3524"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2938"/>
    <dbReference type="eggNOG" id="COG3589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065324_0_0_9"/>
    <dbReference type="OMA" id="QDCGVDK"/>
    <dbReference type="PhylomeDB" id="F9UUI8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2978-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="248"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="351" mass="39294" checksum="B2DAEF39D5572366" modified="2011-10-19" version="1">MLGFSVYLNESLTNERIAQMKAMRNAGFEGVFTSMHIPEDDASCYVPRLKELGTVCRQLGLTLTADVSANGLKRISIDINNIQQLTALGLTALRVDDGLNPAQIAQLSRQLPVALNASTISASDVAKLHECDANFQHLEAWHNYYPRPATGLDYEWYQSKNNWLKQQGFTTMAFVAGDEELRGPVFAGLPTLEGDRYRHPLASTLNLLGKLATDKVYIGDIALSRAALEQFRLYFQHNILQLSIQTSMASLYQDIWHNRPDVARDVIRLVEGRQKIKTMPPMQTRKRPVGTITVDNSRYGRYMGELEILKQSLSADPRVNVVGQVVTTDLSLLALIGSNQAVQFIRKDEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG4</accession>
    <name>Q6LWG4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arsenical pump membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arsB</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in arsenical resistance. Thought to form the channel of an arsenite pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ArsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222023.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133727.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723563"/>
    <dbReference type="EnsemblBacteria" id="CAG17844">
        <property type="protein sequence ID" value="CAG17844"/>
        <property type="gene ID" value="CAG17844"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17844"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3093"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043931_1_0_9"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="PhylomeDB" id="Q6LWG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3144-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01118">
        <property type="entry name" value="ArsB_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00935">
        <property type="entry name" value="2a45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="431" mass="46844" checksum="785DEEAF56A0A68C" modified="2004-07-05" version="1">MQVFFAVFIFLLTLLFVIWQPKGLSIGWTAIGGSVLALLFRVVTFKDVGTVTGIVWNATLSFVAIILISLILDEIGFFEWAALHMARLAKGNGVRMFILIVILGAIVAALFANDGAALILTPIVLAMVRALHFDEKKVFPFIIASGFIADATSLPLVVSNLVNIVSADFFGITFSEYALRMWIPDLFSLIASISILYLYFRKALPKHYDADQVAEPKSAIKDQRLFKFSWVVLAALLIGYFSSSFLNIPVSFIALTIAAIFLLVGQQSHHVDTKAVIKGAPWNIVFFSIGMYVVVYGLQNVGLTTLLAGVIAKMATGSRFVATMGMGYLAAFLSSAMNNMPTVMINALSIKGANVSGLMHQTLVYANIIGSDLGPKITPIGSLATLVWLHVLAQKNVKIAWGTYFKIGITITIPVLFITLCGLWLSLSLFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-29" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE3</accession>
    <accession>F9UR71</accession>
    <name>HIS6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">lp_2554</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE3"/>
    <dbReference type="SMR" id="Q88UE3"/>
    <dbReference type="STRING" id="220668.lp_2554"/>
    <dbReference type="PRIDE" id="Q88UE3"/>
    <dbReference type="EnsemblBacteria" id="CCC79710">
        <property type="protein sequence ID" value="CCC79710"/>
        <property type="gene ID" value="lp_2554"/>
    </dbReference>
    <dbReference type="GeneID" id="57025974"/>
    <dbReference type="KEGG" id="lpl:lp_2554"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2146"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_9"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="PhylomeDB" id="Q88UE3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2202-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142169" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <sequence length="252" mass="26246" checksum="4E35EDF3210F3025" modified="2003-06-01" version="1">MLAKRIIPCLDVADGRVKKGVNFVNLTDVGDPVAIAAAYQQQGADELVFLDIAATNEHRETMAAMVEQVSAQVFMPLTIGGGITSVADMQRILRAGADKTAINSAAVANPELIRAGAEKFGNQCIVVAIDAAWDAAAGQYRVYTHGGQQATDLDAVAWAKQAVALGAGELLVTSMDRDGTKAGFDTKLYQALGATVNVPIIASGGAGNLQDFVDVFSTTPVDGALAASVFHFGELTIADVKATLRKQGVVVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V79</accession>
    <accession>F9UQC8</accession>
    <name>MRAY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">lp_2199</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP</text>
            <dbReference type="Rhea" id="RHEA:21920"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60032"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:70758"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640859.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889931.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V79"/>
    <dbReference type="SMR" id="Q88V79"/>
    <dbReference type="STRING" id="220668.lp_2199"/>
    <dbReference type="DNASU" id="1063536"/>
    <dbReference type="EnsemblBacteria" id="CCC79417">
        <property type="protein sequence ID" value="CCC79417"/>
        <property type="gene ID" value="lp_2199"/>
    </dbReference>
    <dbReference type="GeneID" id="57025726"/>
    <dbReference type="KEGG" id="lpl:lp_2199"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1858"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_9"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="PhylomeDB" id="Q88V79"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1878-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000108841" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="321" mass="35639" checksum="3551D716DA9C5E0C" modified="2003-06-01" version="1">MSLLVWGATLISGFIIVFALMPSLIRYFRARKEGQMIREEGPKWHEKKSGTPTMGGLLFIIAILVTTLWVGGWQHQLQPTTWILMFILVLYGALGFWDDSIKLWRKQNEGLKAWQKLLGQVIGAVILTLVYQHEHLPMALRIPGLGVWSLGIWYMLFAIIWLVGFSNAVNLTDGLDGLVAGQATIAFGAYAVIAYAQNQYNVMLFCLAVVGSLLGFFVYNHKPAKIFMGDMGSLALGGALAAVSILLHHELSLLLIGIIFVIETASVILQVASFKLTGKRIFLMSPIHHHFEMKGWSEWKIDIVFWSIGLVAAVISVATII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ8</accession>
    <accession>F9UQ06</accession>
    <name>UPPS_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)</fullName>
            <ecNumber>2.5.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ditrans,polycis-undecaprenylcistransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Undecaprenyl diphosphate synthase</fullName>
            <shortName>UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Undecaprenyl pyrophosphate synthase</fullName>
            <shortName>UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">uppS</name>
        <name type="ordered locus">lp_2051</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1984" name="Arch. Biochem. Biophys." volume="230" first="49" last="60">
            <title>Undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum: a dimeric protein.</title>
            <authorList>
                <person name="Muth J.D."/>
                <person name="Allen C.M."/>
            </authorList>
            <dbReference type="PubMed" id="6712246"/>
            <dbReference type="DOI" id="10.1016/0003-9861(84)90085-7"/>
        </citation>
        <scope>FUNCTION AS AN UNDECAPRENYL DIPHOSPHATE SYNTHASE</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">0.13 uM for FPP</KM>
            <KM evidence="2">1.93 uM for IPP</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.31"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640735.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889809.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ8"/>
    <dbReference type="SMR" id="Q88VJ8"/>
    <dbReference type="STRING" id="220668.lp_2051"/>
    <dbReference type="EnsemblBacteria" id="CCC79295">
        <property type="protein sequence ID" value="CCC79295"/>
        <property type="gene ID" value="lp_2051"/>
    </dbReference>
    <dbReference type="GeneID" id="57025601"/>
    <dbReference type="KEGG" id="lpl:lp_2051"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1736"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_9"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="PhylomeDB" id="Q88VJ8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1756-MON"/>
    <dbReference type="BRENDA" id="2.5.1.31">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q88VJ8"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:di-trans,poly-cis-decaprenylcistransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000123628" description="Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="6712246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="259" mass="28838" checksum="243B4658138B8323" modified="2003-06-01" version="1">MFAFFNKNDPADNTDVQLDPERIPAHVAIIMDGNGRWAKARHLPRVAGHKEGMNTVKKITIAASDLGVKVLTLYAFSTENWKRPTDEVNYLMQLPVSFFDTFVPDLIKNNVRVQVMGYVDHLPEATQKAVQNAIADTKDCDGMVLNFALNYGSRAEIVTGVQKIAQQVQDGQLAVGDIDDATIDAALMTAPLAPYNDPDLLIRTSGEERISNFLMWQIAYSELVFTDVKWPDFTAATLQACIADFQSRDRRFGGLSDHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VK8</accession>
    <accession>F9UPZ6</accession>
    <name>RBFA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">lp_2039</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101640.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889799.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VK8"/>
    <dbReference type="SMR" id="Q88VK8"/>
    <dbReference type="STRING" id="220668.lp_2039"/>
    <dbReference type="EnsemblBacteria" id="CCC79285">
        <property type="protein sequence ID" value="CCC79285"/>
        <property type="gene ID" value="lp_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2039"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1724"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_3_0_9"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="PhylomeDB" id="Q88VK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1746-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000102679" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="117" mass="13097" checksum="790F2A7C7862C10A" modified="2003-06-20" version="1">MAQHYRVGRLEQEIEREVNDILLKRVRDPRVAGVTITGVTVTGDLQQATIYYSILSDKASDGEKTAAGLAKATGLIRSELGSRLSIYKTPELTFERDNSVQYGSRIDELINNLKRQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W01</accession>
    <accession>F9UPK4</accession>
    <name>DAPB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="1">HTPA reductase</shortName>
            <ecNumber evidence="1">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapB</name>
        <name type="ordered locus">lp_1874</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889657.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W01"/>
    <dbReference type="SMR" id="Q88W01"/>
    <dbReference type="STRING" id="220668.lp_1874"/>
    <dbReference type="EnsemblBacteria" id="CCC79143">
        <property type="protein sequence ID" value="CCC79143"/>
        <property type="gene ID" value="lp_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1874"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1580"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_0_1_9"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="PhylomeDB" id="Q88W01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1605-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000141449" description="4-hydroxy-tetrahydrodipicolinate reductase">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="261" mass="28554" checksum="A89D121AF9811FD9" modified="2003-06-01" version="1">MVKVIVAGYKGRMGSTAAQMVIDNPDFELVGVYDARSEEQNLGEDDRFKGQNVPAFHDLDQIKTDATVWIDFTIPTAVYENAKFALNHGISPVIGTTGMTDEQVAELQKLAKDKQVGGLIAPNFGISAVLLMQFAQQAAKYFPDVEIIEMHHDDKIDSPSGTAISTAKKIAEVRQPKEQGNPDATETLPGARGAEYEGMRIHAVRLPGLVAHEEVMFGGPGEGLTIRQDSFDRISFMTGVKVAVEKVNQYHELFVGLEHLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WH9</accession>
    <accession>F9UP24</accession>
    <name>TRPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpA</name>
        <name type="ordered locus">lp_1658</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640398.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WH9"/>
    <dbReference type="SMR" id="Q88WH9"/>
    <dbReference type="STRING" id="220668.lp_1658"/>
    <dbReference type="EnsemblBacteria" id="CCC78963">
        <property type="protein sequence ID" value="CCC78963"/>
        <property type="gene ID" value="lp_1658"/>
    </dbReference>
    <dbReference type="GeneID" id="57025234"/>
    <dbReference type="KEGG" id="lpl:lp_1658"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1399"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_9"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="PhylomeDB" id="Q88WH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1426-MON"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000098795" description="Tryptophan synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <sequence length="264" mass="28352" checksum="36F2A8B6EE445C6C" modified="2011-11-16" version="2">MTDLTTIFKNHKAFIAFVVAGDPNFEATVDQVVALAEAGCDLVEIGIPFSDPVADGPEIQAADLRAFDQHITPQRVFELVVAIREKTTIPLVFLTYANIVYQFGYAAFAQQCQSLNVAGLIIPDMPLEASGELRPTLDHYGIALIPLIAPTSDDARIAAIAQQARGFIYVVSSLGVTGTRRHITTDLATLVAKIRHATTLPVAIGFGIHEPAQAQAMAQIADGVIVGSAVVHLIATHQPATAVLRDYTRRMRRALDGRTADTVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WY1</accession>
    <accession>F9UNL9</accession>
    <name>MOAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="1">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaA</name>
        <name type="ordered locus">lp_1480</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101426.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889322.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WY1"/>
    <dbReference type="SMR" id="Q88WY1"/>
    <dbReference type="STRING" id="220668.lp_1480"/>
    <dbReference type="EnsemblBacteria" id="CCC78808">
        <property type="protein sequence ID" value="CCC78808"/>
        <property type="gene ID" value="lp_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1480"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1242"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_9"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="PhylomeDB" id="Q88WY1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1269-MON"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="chain" id="PRO_0000152969" description="GTP 3',8-cyclase">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="332" mass="37728" checksum="A8606AE05C6E0C24" modified="2003-06-01" version="1">MEKLYDSYDRLHDYVRLSITDRCNLRCVYCMPKEGLPFFPTDRVLSQDEIVQLIENFAAMGVSKVRITGGEPLLRTDVVEIVRRIKAVDGINDVSITTNGLFLAKLAKPLKEAGLDRLNISLDTFKADRYKKITRGGNIQQVLDGIAVASKLHFKKIKLNIVLIKGQNDDEVLDFLHYTKDHDVNARFIEFMPIGNSLKTWQKEYVGLKNVFDTCKDNGLAYHPIVLRGNGPSDNYQIEGYEGSFGLIHPISSKFCENCNRLRITADGYVKACLYWNEEIDIRSAIGDPVAFRKLIQKALDNKPLNHEMAMSETDRIIDKAPTWRHMSQIGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XS8</accession>
    <accession>F9UMR8</accession>
    <name>CITD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase acyl carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate lyase gamma chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">citD</name>
        <name type="ordered locus">lp_1107</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Covalent carrier of the coenzyme of citrate lyase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomer with a subunit composition of (alpha,beta,gamma)6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CitD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641303.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889021.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XS8"/>
    <dbReference type="SMR" id="Q88XS8"/>
    <dbReference type="STRING" id="220668.lp_1107"/>
    <dbReference type="EnsemblBacteria" id="CCC78507">
        <property type="protein sequence ID" value="CCC78507"/>
        <property type="gene ID" value="lp_1107"/>
    </dbReference>
    <dbReference type="GeneID" id="57024753"/>
    <dbReference type="KEGG" id="lpl:lp_1107"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.936"/>
    <dbReference type="eggNOG" id="COG3052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158489_0_0_9"/>
    <dbReference type="OMA" id="YNWKEID"/>
    <dbReference type="PhylomeDB" id="Q88XS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-950-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00805">
        <property type="entry name" value="CitD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006495">
        <property type="entry name" value="CitD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023439">
        <property type="entry name" value="Mal_deCO2ase/Cit_lyase_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06857">
        <property type="entry name" value="ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002736">
        <property type="entry name" value="Citrt_lyas_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01608">
        <property type="entry name" value="citD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000214703" description="Citrate lyase acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(phosphoribosyl dephospho-coenzyme A)serine" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00805"/>
        </source>
    </evidence>
    <sequence length="96" mass="10394" checksum="04DC76711A763667" modified="2003-06-01" version="1">MEIKTTAVAGTLESSDIQIMLMAGDNGIQIDLESDVIKQFGAQIKHVITTTLQQLNIDNVKVRAVDKGALDCVIKARTITAAQRALETTTPAWEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YD9</accession>
    <accession>F9UM50</accession>
    <name>GLPK2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase 2</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase 2</fullName>
            <shortName evidence="1">GK 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK2</name>
        <name type="ordered locus">lp_0834</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888803.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YD9"/>
    <dbReference type="SMR" id="Q88YD9"/>
    <dbReference type="STRING" id="220668.lp_0834"/>
    <dbReference type="EnsemblBacteria" id="CCC78289">
        <property type="protein sequence ID" value="CCC78289"/>
        <property type="gene ID" value="lp_0834"/>
    </dbReference>
    <dbReference type="GeneID" id="57024530"/>
    <dbReference type="KEGG" id="lpl:lp_0834"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.709"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_9"/>
    <dbReference type="OMA" id="PESGWHE"/>
    <dbReference type="PhylomeDB" id="Q88YD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-724-MON"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059461" description="Glycerol kinase 2">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="508" mass="55952" checksum="D76D1ED6C9FE922D" modified="2003-06-01" version="1">MSAKYIMAIDEGTTSTRTIIFNHAGQKVADAQKEFPQYFPQPGWVEHDATEIWNAVSSTIANVLIDANIKPNQIEAIGITNQRETTVVWDKQTGLPIYNAIVWQSRQTAPLAEQLIADGMGDLIHRHTGLVTDAYFSATKIRWILDHVDGAQKRAERGELLFGTIDTWLVWKLTGGETHVTDYTNASRTMLFNIHDLQWDQTILNLLNIPAAMLPEVRSNSEIYGTTKDYLLYGSQIPISGMAGDQQAALFGQMAFEPGMVKNTYGTGAFTVMNLGEQPQLSDHNLLTTIAYGLDGNINYALEGSIFVAGSALQWLRDGMQLIESAPESESLAQQSHNHNEVYVVPAFTGLGAPYWDSETRGAVFGLTRGTTRADFVKATLQSLAYQSRDVIDTMKNDANITMPTLMVDGGAARNNWLMQFQADISNVKIIRAADLETTALGAAFLAGLAVGYWQDLDELKSIHQTGNVFQPRMAAPQRANLYQGWQAAVKAAQLFKHTPIDAQSSTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YH9</accession>
    <accession>F9UM07</accession>
    <name>CLPP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP</name>
        <name type="ordered locus">lp_0786</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888760.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YH9"/>
    <dbReference type="SMR" id="Q88YH9"/>
    <dbReference type="STRING" id="220668.lp_0786"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="CCC78246">
        <property type="protein sequence ID" value="CCC78246"/>
        <property type="gene ID" value="lp_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="57024487"/>
    <dbReference type="GeneID" id="66448749"/>
    <dbReference type="KEGG" id="lpl:lp_0786"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.663"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_9"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="PhylomeDB" id="Q88YH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-681-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179575" description="ATP-dependent Clp protease proteolytic subunit">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="196" mass="21529" checksum="3436A48FD279BA8D" modified="2003-06-01" version="1">MYPVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIEDNMANAIIAQLLFLDAQDSGKDIYLYINSPGGVVTAGLAIYDTMNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPNSEILIHQPSGGAQGQQTEIEIVAEEILKTRKKINQILADNSGQSVEKLNHDTERDNYLSAQEAKDYGLIDDIMENNKLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-09" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YK8</accession>
    <accession>F9ULX6</accession>
    <name>PSTB1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB 1</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB1</name>
        <name type="ordered locus">lp_0749</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888729.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YK8"/>
    <dbReference type="SMR" id="Q88YK8"/>
    <dbReference type="STRING" id="220668.lp_0749"/>
    <dbReference type="EnsemblBacteria" id="CCC78215">
        <property type="protein sequence ID" value="CCC78215"/>
        <property type="gene ID" value="lp_0749"/>
    </dbReference>
    <dbReference type="GeneID" id="57024449"/>
    <dbReference type="KEGG" id="lpl:lp_0749"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.630"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="AFMYMGD"/>
    <dbReference type="PhylomeDB" id="Q88YK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-650-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092826" description="Phosphate import ATP-binding protein PstB 1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30401" checksum="DBBB0B4ECA7ABF09" modified="2003-06-01" version="1">MADNTMTTTQRNIMAFDPKDHEIALSTEDLHVFYGKSEAISEGDLQFERYKISALIGPSGSGKSTYLRSLNRMNDRIATVKGKIMYRGLDINSNDIDVYEMRRHIGMVFQRPNPFAKSIYENIAFALRQRGMNKKQDLDEIVERSLRQAAMWDQVKDDLNKSALALSGGQQQRLCIARAIAIKPDILLLDEPASALDPVSTSQIEDTLLELKQNYTIIIVTHNMQQASRISDYTAFFNLGKVLEYSETGEIFTNPQVDLTNDYISGNFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q890C2</accession>
    <accession>F9UST6</accession>
    <name>THIM_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="1">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="1">TH kinase</shortName>
            <shortName evidence="1">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiM</name>
        <name type="ordered locus">lp_0113</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888181.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890C2"/>
    <dbReference type="SMR" id="Q890C2"/>
    <dbReference type="STRING" id="220668.lp_0113"/>
    <dbReference type="EnsemblBacteria" id="CCC77667">
        <property type="protein sequence ID" value="CCC77667"/>
        <property type="gene ID" value="lp_0113"/>
    </dbReference>
    <dbReference type="GeneID" id="57026953"/>
    <dbReference type="KEGG" id="lpl:lp_0113"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.91"/>
    <dbReference type="eggNOG" id="COG2145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_0_0_9"/>
    <dbReference type="OMA" id="NFVANAQ"/>
    <dbReference type="PhylomeDB" id="Q890C2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-89-MON"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156940" description="Hydroxyethylthiazole kinase">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <sequence length="263" mass="27521" checksum="CC4E65F7DC6FF44F" modified="2003-06-01" version="1">MELQLLNTLRNHNPIVFNIANFVTVQDVANGLNALGASPIMSAEVQEAETMVQIAGAVCINLGTLTTTQIDQMRVVGKLANQYHKPVVLDPVAVGAVPYRKEVALALLSDFQVDVIRGNAGEIAALAGMDWQAKGIDAGSGQGDLVEIAQACAQQFQCCVILSGPTDVITDGQRVVKVANGTPLFQRHVGSGDLLSSIVAAFTAVSPTDVYQAAQVACLVLAGAGELVASQLTADRPATFAIDLIDRLSLVTVSEIQTIAKVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q890K8</accession>
    <accession>F9US33</accession>
    <name>DNAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaA</name>
        <name type="ordered locus">lp_0001</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641628.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890K8"/>
    <dbReference type="SMR" id="Q890K8"/>
    <dbReference type="STRING" id="220668.lp_0001"/>
    <dbReference type="EnsemblBacteria" id="CCC77580">
        <property type="protein sequence ID" value="CCC77580"/>
        <property type="gene ID" value="lp_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="57026864"/>
    <dbReference type="GeneID" id="66448158"/>
    <dbReference type="KEGG" id="lpl:lp_0001"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_9"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="PhylomeDB" id="Q890K8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114194" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="455" mass="51463" checksum="15EA1AD93A65E9AC" modified="2003-06-01" version="1">MLERNDLWNLIKFSMEQDLSKITFQTFVEPAKPLQLDKAQMTIEVPTQLHRDYWEKNLAAKFTDIAMQATNEQIRPVMITEEERQQLTRDKDSQVTTGNVAGQQPTTATTPTFMRETKLNPKYTFDTFVIGKGNQMAHAAALVVSEEPGTMYNPLFFYGGVGLGKTHLMHAIGNKLLETDPTSNIKYVTSESFTNELINAIQTKKQEAFREEYRNVDLLLVDDIQFFANKEATQEEFFHTFNALYEDDKQIVLTSDRLPNEIPQLQDRLVSRFKWGLSVDITPPDLETRIAILRNKADLEGIEIPDDTLSYIAGQIDSNVRELEGALARVQAYSRLNNSPITTSLVADALKSLHLSSKLSEVSIPVIQEKVAKYFHVTMADLKGKKRNKQIVIPRQIAMYLSRELTESSLPRIGNEFGGKDHTTVIHAHDKITKALKTDAELQKAVGDLTGQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW0</accession>
    <name>F9UKW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101019.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0477"/>
    <dbReference type="EnsemblBacteria" id="CCC77975">
        <property type="protein sequence ID" value="CCC77975"/>
        <property type="gene ID" value="lp_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0477"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.392"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067270_2_0_9"/>
    <dbReference type="OMA" id="VQIYLCI"/>
    <dbReference type="PhylomeDB" id="F9UKW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-396-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="310" mass="34357" checksum="45A46ABA36535403" modified="2011-10-19" version="1">MSKPMQRYHFSSIISDDTDNGGGFIMRHPSCPIIADNGVAFLTESTIATLSQKYEPAAMLDSFAYTNALLWLTAARQQPIVHFWQLQPTVILGLLDQRLPRLTAGLADLHAAGYQIMLRNSGGLAVVADPGVLNVSLFLPATRERYPITAAYQLMVDYVQAVWPQLNITTGEITRSYCPGDYDLSIAGRKIAGMSQRRTAEALVIMLYVSVDGDQMARSQLIQRFYQVSLAGHHDARFPDVDPQVMTTVADALAAPTDTTATQARFIAILAQHGTVDTTSLPLVTEEPEFQAHLNQAYQQMQRRQQRLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKW1</accession>
    <name>F9UKW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642040.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888490.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0479"/>
    <dbReference type="EnsemblBacteria" id="CCC77976">
        <property type="protein sequence ID" value="CCC77976"/>
        <property type="gene ID" value="lp_0479"/>
    </dbReference>
    <dbReference type="GeneID" id="57024274"/>
    <dbReference type="GeneID" id="66448549"/>
    <dbReference type="KEGG" id="lpl:lp_0479"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.393"/>
    <dbReference type="eggNOG" id="COG4506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120388_3_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-397-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16495" checksum="41B435DEF5FBDE9F" modified="2011-10-19" version="1">MDDLTTGVPVAIHLETQARQDDDTANYALDVDGQLVQMGDAFYLRYKEVNDDAPEPIPVTIKLAANGDVVLTRSAENRLRLHFSNGKRVRAHYQTPMGMLPVETVTPMLRVRLRERPFSGEVNVDYDLYAGEQLLGNYKLRLQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKY5</accession>
    <name>F9UKY5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888514.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0507"/>
    <dbReference type="EnsemblBacteria" id="CCC78000">
        <property type="protein sequence ID" value="CCC78000"/>
        <property type="gene ID" value="lp_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0507"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.417"/>
    <dbReference type="eggNOG" id="COG2964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080179_2_0_9"/>
    <dbReference type="OMA" id="VMQTLEF"/>
    <dbReference type="PhylomeDB" id="F9UKY5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-421-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="242" mass="27131" checksum="13B0C1BF3451B518" modified="2011-10-19" version="1">MQKPLTAEQEYVREFIPFVDFLADILGPSSEVVLNDLLDLNHSVVAIRNSHISHRQVGDPATDLALRTMKAGKAEKRDYLANYKGVSQGKHSLRSSTYFLRLDGEIVGMICINTDDSALDDLQEQVLKVMASYKHLNSPTIHQLKGTPANEKAHDTPVAPEHLTTSITDLAREVTQAVCAKYGVSVEYLKQNEKLEIVRSLYHQGYFLLKDSVSEAAKVLKVSDPSVYRYLQTVKDEDLQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL55</accession>
    <name>F9UL55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma54 activator, mannose PTS operon regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">manR</name>
        <name evidence="6" type="ordered locus">lp_0585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101067.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888584.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0585"/>
    <dbReference type="EnsemblBacteria" id="CCC78070">
        <property type="protein sequence ID" value="CCC78070"/>
        <property type="gene ID" value="lp_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0585"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.489"/>
    <dbReference type="eggNOG" id="COG1221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014204_1_1_9"/>
    <dbReference type="PhylomeDB" id="F9UL55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-501-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="3">
        <location>
            <begin position="105"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="5">
        <location>
            <begin position="465"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-4" evidence="4">
        <location>
            <begin position="573"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="5">
        <location>
            <begin position="844"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="949" mass="105198" checksum="93F2D42037D7537A" modified="2011-10-19" version="1">MTRKSKICEYVRQHSDRHGLTTEMVATALMIARSNVSKELNALVREGQLHKLTGRPVHYVPVNATATTATTTSGVANGATTERIPTAPVATSVPKPVVNDIFASMIGSHESLANQVEQAKAAILYPPRGLNTLIIGPTGSGKTYFANAMYRFAETQQVLTNPQGLITFNCADYAHNPELLMSHLFGYVKGSFTGANEDKDGLIQEADGGMLFLDEVHRLPPEGQEMIFYFMDHGTYSRLGETAKSHHANVRLVCATTEDPESTLLQTFVRRIPITIQLPAFNHRSAKERLELLKALLSLEANRINKQIRLTEDVVQALLGSVTFGNVGQLKSNIQLVCAQGFVNSIENDSEITITMDDLPQNIRSGLMTVASNRHELGAISELLDPVLIVKPNDGPTPLRNKNDNYELPYNLYEIIGDKAALLRREGLDKEHINRFITTDINVHLKSFYKQNQLEVSPENKLAEIVDQDVIDFTKTAQMTVQDMLGYNFKDNFIYAVSLHVSSFIKRIQAGKPMRQMSSDMLAMVREYPAEIKAAEALKQGLEERYHLPIPKSEVYYLAILLISLKSMQLNGKVGVLVAAHGMSTASSMAQVVGQLLDDYDVQAFDMPLDMDPSVAYDHVKRRVEKLDSGKGILLLVDMGSLTTFGERIQQETGIATRTIDMVTTPVVLEAVRKASLVDSDLDSMYQELVGFKGYSRISRNLPTDSQRATVKPALATDKTAQRAIIAICATGVGTAERIKSILDSLLAQNFIEGITVFPISVVEMKTRIQQISQNYQIIAATGITKPELDVPFISLEELLQGGGEKFIDQLATGIDSPQTMAEESQQLTPELCERYLGDYFTFLNPKKLTGILWEYSEVIATHLDGVMTNAFRIDLIMHLAGALERTAIKDEISAPTEEMPDIMASKWYPLVQQANQQLTDQLQLTFSDAENYYIVQLLETHQAKVAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL96</accession>
    <name>F9UL96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101084.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888625.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0633"/>
    <dbReference type="EnsemblBacteria" id="CCC78111">
        <property type="protein sequence ID" value="CCC78111"/>
        <property type="gene ID" value="lp_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0633"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.529"/>
    <dbReference type="HOGENOM" id="CLU_2246586_0_0_9"/>
    <dbReference type="OMA" id="PFELNEH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-544-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11940" checksum="9404B7D74DF60530" modified="2011-10-19" version="1">MLTATIHFLDGETLTLNVHDFVWGIRTAPINDRPKKFSKKNWEKITYDFPNKDEINGPFELNEHIKLGLVPSITKLLNNYTFFFTDDDPGTVFASSKVVKIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA2</accession>
    <name>F9ULA2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0639"/>
    <dbReference type="EnsemblBacteria" id="CCC78117">
        <property type="protein sequence ID" value="CCC78117"/>
        <property type="gene ID" value="lp_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0639"/>
    <dbReference type="HOGENOM" id="CLU_3201367_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-550-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="56" mass="6472" checksum="0B050D79EA36F008" modified="2011-10-19" version="1">MKLLVGLEFKEMKTMKFTFRIGNVLYKQITIEELNNVFGTFKEVERIGSTQSIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="6" type="ordered locus">lp_3565</name>
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    <organism evidence="6 7">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3565"/>
    <dbReference type="EnsemblBacteria" id="CCC80527">
        <property type="protein sequence ID" value="CCC80527"/>
        <property type="gene ID" value="lp_3565"/>
    </dbReference>
    <dbReference type="GeneID" id="57026763"/>
    <dbReference type="KEGG" id="lpl:lp_3565"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2974"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_9"/>
    <dbReference type="OMA" id="MMMLYMG"/>
    <dbReference type="PhylomeDB" id="F9ULC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3015-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="68"/>
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            <end position="107"/>
        </location>
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            <end position="133"/>
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            <end position="205"/>
        </location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="398" mass="42368" checksum="83DD0F7E08191F13" modified="2011-10-19" version="1">MNYLLQLVLILLLTKLGAHIAATFNLPSVIGELLVGILAGPAVFHILTYSTFIQYFAEIGVIILMFIAGLEGDLKLLFRYWKPALTVATLGVIFPTASAVLLCVGMFDFSLTTSIFLGLILSATSVSITVQVLKEMDYLNTREGAIILGAAVADDIICVVLLGISTSLFGTASAHNQSLVAMVLPKVLFFVVVIALAKWFVPLFLRGFNKVNASENITTAAMVLCFGFSFLAVKLGMSDVLGAYIAGLAISETRFKAQLVAKVEPIGYAVFIPAFFVSIGLEITFKGMQNDLVFIGLLLVLAILGKQIGGAIGGKLFGLTWNEANIVGAGMVSRGEMALVVANVAVSAGLIDHNHYTAMIVVTVMATLIAPSMLKTFIQHGKRAVSHISLNKTSEAKS</sequence>
</entry>
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    <accession>F9ULI4</accession>
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            <fullName evidence="6">ABC transporter, ATP-binding protein, mannose related oligosaccharides</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004891105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3635"/>
    <dbReference type="EnsemblBacteria" id="CCC80591">
        <property type="protein sequence ID" value="CCC80591"/>
        <property type="gene ID" value="lp_3635"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3635"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3035"/>
    <dbReference type="eggNOG" id="COG3842">
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    <dbReference type="OMA" id="APPMNLM"/>
    <dbReference type="PhylomeDB" id="F9ULI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3078-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="378" mass="42409" checksum="C53A4D8550415B6C" modified="2011-10-19" version="1">MVEINLDHIYKRYPNAETNSVNDFDLHIKDKEFIVFVGPSGCGKSTTLRMIAGLEDITQGTLEIGGKVMNDISPKDRDIAMVFQNYALYPHMTVAGNMAFGLKLRKYKKDDIAKRVDQAAEILGLTEFLDRKPADLSGGQRQRVALGRAIVRDAPIFLMDEPLSNLDAKLRVSMRAEIAKLHQRLSTTTIYVTHDQTEAMTMADRVVVMSVGEIQQIGTPSEIYDRPRNMFVAGFIGSPAMNFFNVHYQDQVIDDHKGVQLTIPEGMAKVLDKRGYNGKDIVFGIRPEDIHTEEIFIDTWPNSTVEATINVSELLGATSQLYSQVGNTEFVANVDSRDFHQPGAKVQMGFDINKAHFFDKETQNSIMLDEEEETGKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK1</accession>
    <name>F9ULK1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, glucitol/sorbitol-specific EIIC component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts38C</name>
        <name evidence="2" type="ordered locus">lp_3654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641598.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3654"/>
    <dbReference type="EnsemblBacteria" id="CCC80608">
        <property type="protein sequence ID" value="CCC80608"/>
        <property type="gene ID" value="lp_3654"/>
    </dbReference>
    <dbReference type="GeneID" id="57026834"/>
    <dbReference type="GeneID" id="66451081"/>
    <dbReference type="KEGG" id="lpl:lp_3654"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3052"/>
    <dbReference type="eggNOG" id="COG3730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093147_0_0_9"/>
    <dbReference type="OMA" id="FQEGGNQ"/>
    <dbReference type="PhylomeDB" id="F9ULK1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3095-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004699">
        <property type="entry name" value="PTS_IID_sorb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40399">
        <property type="entry name" value="PTHR40399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03608">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038321">
        <property type="entry name" value="PTS_glc_srb_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00821">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51107">
        <property type="entry name" value="PTS_EIIC_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20240" checksum="5772DFB45B24C52E" modified="2011-10-19" version="1">MKVVTDLASGFMGLFQSGGKTLIGWMTSIIPVVLLLLVLMNAIIAFVGDKKMAKLARASSKNPVTRYLILPFVSAFMLGNPMAHSMGRFLPEYYKPSWYASIAQFCHTSNGVFPHINPSEYFIWLGIAQGVQKLGLNTMDLAIRYLLVGLVMNFIGGWITDFTTAYVCKQQGITLSKKVEFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK2</accession>
    <name>F9ULK2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sorbitol operon activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">srlM2</name>
        <name evidence="1" type="ordered locus">lp_3655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641599.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3655"/>
    <dbReference type="EnsemblBacteria" id="CCC80609">
        <property type="protein sequence ID" value="CCC80609"/>
        <property type="gene ID" value="lp_3655"/>
    </dbReference>
    <dbReference type="GeneID" id="57026835"/>
    <dbReference type="KEGG" id="lpl:lp_3655"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3053"/>
    <dbReference type="eggNOG" id="COG4578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124480_0_0_9"/>
    <dbReference type="OMA" id="QIALGWW"/>
    <dbReference type="PhylomeDB" id="F9ULK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3096-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009693">
        <property type="entry name" value="Glucitol_operon_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06923">
        <property type="entry name" value="GutM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011474">
        <property type="entry name" value="Glucitol_operon_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="19290" checksum="70E95961D9307861" modified="2011-10-19" version="1">MLIYFGVILVSAFLLQGFLGLRQIKNFSKTFHQLRVLAPVAIGKNPKKLRSGTLILLAIKDDGTILEAQMMKGVTIFAKFRELHQLRQKNIAEIAASYQQLKQFDKLTRVCLLDAYKNYLNYKANQLTPQDFDGSVKIWSLPMIEKLKSIYYKGLASLRKKQVNVKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULM0</accession>
    <name>F9ULM0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein, CscD family,LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641618.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891141.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3677"/>
    <dbReference type="EnsemblBacteria" id="CCC80627">
        <property type="protein sequence ID" value="CCC80627"/>
        <property type="gene ID" value="lp_3677"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3677"/>
    <dbReference type="HOGENOM" id="CLU_2130323_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3114-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="113" mass="12872" checksum="DF1129C79161D06F" modified="2011-10-19" version="1">MVQRFSVCVATILISLIMLTITGVAAVGGRSTVTVSFYAGQRTQQQIDNRNVKIPNGTRPYRVVTEKTLTRPKGYYQLPQTDEQLLTWFYASFGSVLLILLMVIRWFNKESYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR1</accession>
    <name>F9ULR1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P1 protein 50, tape measure protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888664.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0673"/>
    <dbReference type="EnsemblBacteria" id="CCC78150">
        <property type="protein sequence ID" value="CCC78150"/>
        <property type="gene ID" value="lp_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0673"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.565"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003937_0_0_9"/>
    <dbReference type="OMA" id="GHAGIDY"/>
    <dbReference type="PhylomeDB" id="F9ULR1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-584-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013491">
        <property type="entry name" value="Tape_meas_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20155">
        <property type="entry name" value="TMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02675">
        <property type="entry name" value="tape_meas_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="TMP_3" evidence="3">
        <location>
            <begin position="223"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1334" mass="146164" checksum="A5E3E60BB6B732D5" modified="2011-10-19" version="1">MSAVVEKTFVWKFMDQISQGVANARQAMGEAVRAATSMGSKVSESGEQWRNYASKQKEAMDEAKANFNEYKDQVTNSSNSIREKINGLIDHLKEIPHDVMTTLKSKINDENIGLFSRKVRDVPKERSVFLRAKDKFTNMFKHLSERIKQIPKEHSLLLKVKDGFSKGFQKFNESAKKTRENGHRLRDIIEGTFIGNALYGAYDKVKDGIIEATKAGYDFDKEQQVMLQTWTTLTGSANQAKGMVSTINDLSKKTGQASSLVNELEQGFYHLHSSKSEADDLSKAMLNMGDAVGLTGDQMKSVTQDMVHGLATGKVSAGELNQIGAYFPMIDEALAKHEHTTVAGMRNMARQGKITGKDLESVFTELGNHKYGEAADNMLQTMTGMQRTVKAQMPKLLGEIEEPLLKAQNPIFGTISKWVSESHTENLFKDLGNKVNKGFATVTKAFAGDNFTGKGFTNSLDQMIENAGKSVNKLSAWLAKNAGNIKEFGSIVKSSLTIAFKVMGAAINDVVSVLGFVVNPLGRVSNHSKDASKSVGGLANGLKSLSSNGPAIQTFGKILAGAFVLKNVSKFIGGIKSINDNLKITTGLKNLGKPVTEFATSLKSGSGVLSSFGAALKAVPFTIWIIAIAAIVLALVELYKHNKKFREFVNGLVDTIKVWYKDATKWLGNAVAWIKKTFGPFFKSAVKSIQSVWKEIEPVVSAGIKMVQKVLKLGMAVVSALWKVAWGYLSLEVKETWAIIKPIIDIGMAVIKGLISAGMDIIKAVWKAAWKVISTVVRSVWNVIKPLIIGAMNVISDVIQTILDIIHGNWSKVWGDIKNIFSDIWKAISQAIKAYMSGMHDIISSVLDTISTVWHGMWQGLGDFFKNIWKGIKQAAQDGINGVLSVINAGVDAIDSVWKFFTGHKTSIRHLDPVKFAQGGVVHTRLSMVNDGAGQNWKELLQLPSGELKMTHQRNAVLPLPVGTRVYNGDETASIMTSAGVDHYANGGIVGDAINWTKGKLSDIGSWIGDKAEAVEKFLKDPLGNISKLLHKATDGLFKRAASFGDLASGTISKLSSIAVDKFKEMLNSNKKSLEVSDGKAGHYNPGLIEKATKMMHIDSLPAGFSELLQATIMSESGGKSVIQTIHDGNSGGNEAGGILQFTPGTFAAFAMPGRTNRMNPLDELLAFFNNSDWRNSIGHTVIWGVPKVDWLHSGPQGHRRFAHGGEVFDEQTVIVGDNSQHHEFVINPYDVTAYPLLAKAMDTTMRAQPIADVNTNIDHRDSSETNSLLRKLLKVITDDQQSTEDDSLTNMLSRILVALKQDRPVYLNANGRLIDITNEQLGERMEDERRYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM05</accession>
    <name>F9UM05_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888758.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UM05"/>
    <dbReference type="STRING" id="220668.lp_0783"/>
    <dbReference type="EnsemblBacteria" id="CCC78244">
        <property type="protein sequence ID" value="CCC78244"/>
        <property type="gene ID" value="lp_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0783"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.661"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="WQPDFPS"/>
    <dbReference type="PhylomeDB" id="F9UM05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-679-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388826" evidence="3">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="79"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="550" mass="61086" checksum="4CD294CACBF21928" modified="2011-10-19" version="1">MKKRSVLAVVMSLVLVTVLAACGKHNSQSSGNGKYASSQVLNLSYPSSLDSIDISNMSGYGSTGNIFESLYRLGKNGSITPGLAKSTKVSKDGKTYTFTIRNAKWSDGSKITAQDFVYSWKRTVTPATKSQYAYLFSGVKNADEIVAGKKSPSTLGVKAQGEHTFIVTLDKPITYFKKLMTYPLFGPISEKAVKKWGNKYATKAQYMLYSGPFKLTGWTGTNNSWQFVKNNQYWDKKAVHLQKINYTVNESTTTTLNLFQEKKLDLTQLASEQVKNMKSSSDYTTYPYSITAFLVYNFQDSNATIKKALNNAKIRQAISLSINRKTLVKNVIGDASTVSKTFVPQDLVKDAKTGKDFADESTVKNSTSYNKALAQKLWKQGLKETGIKKLSIQLLASNDEPNKPISQYLKSALEKNLDGLTVNLSNIPSKVASSRAQSGDFDLYLSGWGADFNDPISHLQIMTNNSGYNYGKYNSSTYNALVNKAQNQDANDTSARWQDMINAEKTIMKDQGITPLYQTVYSYLQNPKVKGIIHNTAGTQWNYKYAYIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM18</accession>
    <name>F9UM18_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase</fullName>
            <ecNumber evidence="4">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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        <source>
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        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
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        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.1" evidence="4"/>
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        <property type="family name" value="CarbLipBact_1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78257">
        <property type="protein sequence ID" value="CCC78257"/>
        <property type="gene ID" value="lp_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="57024498"/>
    <dbReference type="KEGG" id="lpl:lp_0796"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.674"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_076594_2_0_9"/>
    <dbReference type="OMA" id="DWYAEVD"/>
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        <property type="organism ID" value="2849"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="27926" checksum="84041820CFCAC7B9" modified="2011-10-19" version="1">MMLKQPEPFFFEHGQHAVILLHAYAGSANDVRMLARALEREDYTVYGPQFSGHATDDPRDILAQTPAQWWQDTQQAISFMRQKGYTKISIFGLSLGGIFATAALERDPQLLGGGTFSSPLFAGNRSDVAEMFITLSHHQLAHSQFSIAEREQILMTLPELVQRQLQAVNTFTTTEVTSHLSAVTQPFFIGQGGQDELIDATVARQLRDQLPQVPVDFHWYADAGHVITVNSAHHQLEQDVLTYLKTIYK</sequence>
</entry>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888807.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78293">
        <property type="protein sequence ID" value="CCC78293"/>
        <property type="gene ID" value="lp_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0838"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.713"/>
    <dbReference type="eggNOG" id="COG4767">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="53"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="94"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="124"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="170" mass="18903" checksum="154898283FB92E24" modified="2011-10-19" version="1">MRWEPFRIILIVATLSCLVILVHVRQPQARTRQLLGLSYLFGLSVILFTPLSFDGTAIYVMPAGVGQVNLSRLYLHGLGFIENIILTFPLGWGIKRHFHHYPLLGLGLTGLLVGASIESLQYFMSQHWLINRSSDINDVIANATGILIGGPVAATFQFVAQHRKTSVTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM86</accession>
    <name>F9UM86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnM</name>
        <name evidence="8" type="ordered locus">lp_0882</name>
    </gene>
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="GeneID" id="66448829"/>
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    <dbReference type="OMA" id="QLVPMWA"/>
    <dbReference type="PhylomeDB" id="F9UM86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-761-MON"/>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23739" checksum="50030A73A0ADB66F" modified="2011-10-19" version="1">MGYILTHYWSELIQGLGYTLLSSVIALVFSTIIGTMFAIFEVLPSRTMRIIGRVYIEIFRNIPLLVIAMFFYVIIPMYVAKIDGFTAGTIGLTIYTSSFIAETVRAGIQSVDPGQMEGARANGMTYWQAMSKIVLPQAFKIIIPPLGNQFINLVKNSSVLAFVAGFDLMYQANSIASLSLDTINSYVVVGVFYLIITLPLSYYMRHLEKKLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM97</accession>
    <name>F9UM97_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101192.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888850.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0894"/>
    <dbReference type="EnsemblBacteria" id="CCC78336">
        <property type="protein sequence ID" value="CCC78336"/>
        <property type="gene ID" value="lp_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0894"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.757"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_10_0_9"/>
    <dbReference type="OMA" id="FPPHIAI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-772-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="253" mass="26617" checksum="5BCD5DB96CBCD2AF" modified="2011-10-19" version="1">MIQFKGEFTTFVFLSGLLIGIFVSLIGGGGAALYLGVLTSQVGLATAVAVPTSLIVALPALFFGFLTQLKIKNVNFKIGNQMIIAAVPGIIVGTFSAQFIPQQLYNWIVGTIFLIMGAMVLIKYVHHSKQTTAGHQPWQAAFFGLLSGLMVGIGGLSGGATTAAGLAILGLTAVEAAGTATYVLTVMSTISLIGHLFTSTFAWQSGLVLMIGAIIGAIITPLVIRHLNLDKVNRVLTPFLGLIIIYFGIKMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC0</accession>
    <name>F9UMC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101205.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMC0"/>
    <dbReference type="STRING" id="220668.lp_0921"/>
    <dbReference type="EnsemblBacteria" id="CCC78359">
        <property type="protein sequence ID" value="CCC78359"/>
        <property type="gene ID" value="lp_0921"/>
    </dbReference>
    <dbReference type="GeneID" id="57024600"/>
    <dbReference type="KEGG" id="lpl:lp_0921"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.779"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_9"/>
    <dbReference type="OMA" id="KINILYH"/>
    <dbReference type="PhylomeDB" id="F9UMC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-795-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="114" mass="12784" checksum="6A3C04F9415F5CCF" modified="2011-10-19" version="1">MRTITPIENSRRHEEFCPLDTTLSILSGKWKSIIICRLMGSSQRFSSLLKGMPGCTSRMLAMQLKELVADQIVSQQTVANHSVYELTNIGVSLVPIVEAMDRWGKAYLETLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH0</accession>
    <name>F9UMH0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartokinase</fullName>
            <ecNumber evidence="14">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">thrA1</name>
        <name evidence="17" type="ordered locus">lp_0979</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 14">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="14"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101238.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004888923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0979"/>
    <dbReference type="EnsemblBacteria" id="CCC78409">
        <property type="protein sequence ID" value="CCC78409"/>
        <property type="gene ID" value="lp_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="57024650"/>
    <dbReference type="KEGG" id="lpl:lp_0979"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.832"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_1_9"/>
    <dbReference type="OMA" id="LMSCGEV"/>
    <dbReference type="PhylomeDB" id="F9UMH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-845-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:diaminopimelate biosynthetic process"/>
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    </dbReference>
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        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:threonine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="340"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCC78409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="400" mass="42809" checksum="94248EB7A0562118" modified="2011-10-19" version="1">MEIIVQKFGGTSVKDEAARIQALKHVQYAVDQGDKVIVVVSAIGRKGAPYATDSLLGLVGAEHSRLTNRELDMLVSVGETISTAVFTELARKQGLNVTAMTGHDAGIVTNDDFQNAKILRVDPKPITDAFIDADVVVVTGFQGATESGHVTTIGRGGSDTSAAILGAALKAKRVDIFTDVNGMMTADPRLVTHARFIKAISYEELANMAHEGAKVIHPRAVEIAEQAHVPMRIRSTYQEPDELGTLVTDRTTTQIEHYRTVTGIAHQTDLTQFTVPTDTLSSSAIFQLMAQHGLSVDFINITPHQVVFNLVDGDADVAKQLLTDAHVHCQSIANCAKVSVVGAGITGTPGVTARIVSALAAQHIDILQSTDSYTTIWVLVKEADLKAAMNALHDEFLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMH1</accession>
    <name>F9UMH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolysing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB1</name>
        <name evidence="9" type="ordered locus">lp_0980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101239.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888924.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0980"/>
    <dbReference type="EnsemblBacteria" id="CCC78410">
        <property type="protein sequence ID" value="CCC78410"/>
        <property type="gene ID" value="lp_0980"/>
    </dbReference>
    <dbReference type="GeneID" id="57024651"/>
    <dbReference type="KEGG" id="lpl:lp_0980"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.833"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_0_9"/>
    <dbReference type="OMA" id="DIHTWMR"/>
    <dbReference type="PhylomeDB" id="F9UMH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-846-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="633" mass="73140" checksum="23396F3B7E84DCC9" modified="2011-10-19" version="1">MCGFAGCLTDRTKADNAAYDQTIHEMTKMIVHRGPDDDGYFADDNITMGFRRLSIIDLAGGHQPLSYDNERYWMTFNGEIYNYVELREQLKQEGYEFKTSSDSEVILAMYAKYHADATKYLRGMFAFVIWDKQEKTLFAARDQFGIKPFYYAISGDDFYYASESKAIYKILKDKTFDKNALQDYMTFQFVPEPETLTKEIKMLAPGCSLTKKLGSAPRIDRYYHREFHPVERSEDEYAQKIKDALIDSVKIHMRSDVPVGSFLSGGIDSSIIVAIAKNFNPNLETISVGFEREGYSELDVAQETAEKLGVKNYSMTITPEAFMKAFPHFVWSMDDPLADPAAVPQYFLAKEAVKHVKVCLTGEGADELFGGYTIYHEPESLKPFRYTKPINGALKRIALMMPEGMRGRSFLLRGTTPLENRYVGNAFIFGEQEKQAFFKNYNQNHPFQSITQPLYDESVDYDPISRMQFIDMHTWLNGDLLHNADRTTMAHSLELRTPFVDREVYNLAAEIPADLRISHGTTKYILRKAVEDIVPAHVLHRKKLGFPVPIRFWLKDEMYDWAKQIINDSQTDQYFNKDYFLKLLDDHKAGVRDNSRKLWTVLTFMMWHRLYVESDHLMDSPEANAVAEKVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ6</accession>
    <name>F9UMJ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent Clp protease, ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpC</name>
        <name evidence="11" type="ordered locus">lp_1019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101242.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888949.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1019"/>
    <dbReference type="EnsemblBacteria" id="CCC78435">
        <property type="protein sequence ID" value="CCC78435"/>
        <property type="gene ID" value="lp_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1019"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.861"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_9"/>
    <dbReference type="PhylomeDB" id="F9UMJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-878-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="9">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="837" mass="92657" checksum="E2AE3B4941C39811" modified="2011-10-19" version="1">MDNLFTPSAKSVLVLAQEQAKYFKHQAVGTEHLLLALAIEKNGIANKVLQQYAVSEDDIREEIERFTGYGTLSNVGKDTYLPYSPKAKEILSVAGDEAKRLGANKIGTEHLLLAMLSDESILSSRILMNLNLDLGQTRKVVLRKLGVSDAMSKRKGNAANRGGKKTEGTPTLDSLARDLTQLASEQEMDPVVGRSKEVKRVIQILSRRTKNNPVLIGEPGVGKTAIAEGLAQKIVAGDVPTDMADKRLMMLDMGSLVAGTKYRGEFEDRLKKVIDEIYNDGHVILFIDELHTLIGAGGAEGAIDASNILKPALARGELQTIGATTLNEYQKYIESDAALERRFATVMVNEPTEDEAVEILDGLRPRYEEHHRVTITDEAVDQAVKLSSRYISDRFLPDKAIDLMDEAAAKVRIDQMDQPTKLSKNQDKLAQLREDKETAIEAQDFEQAADIRKQEMQLKQRLDRIEADQDAEVTEGATPHYDLQVTGEDIAQVVAEWTGVPLTQLQKSESERLVNLEKILHERVVGQPEAVSAVARAIRRARSGLKDPSRPIGSFMFLGPTGVGKTELAKALAAAMFGSEDNMIRIDMSEYMERYSTSRLIGSAPGYVGYDEGGQLTEKVRQKPYSVVLFDEVEKAHPDVFNILLQVLDDGYLTDSKGRKVDFRNTILIMTSNLGATTLRDEKSVGFGATDKANDYNAVAATIRATLKQTFRPEFLNRIDETIVFHSLNKEELHEIVKLMSQEIVDRVAQQGIKIKITPAAIDVVAKAGFDPEYGARPIRRALQTEIEDRLSEELLTGAIKVDDQVTIGASKGTITINIKTSLRQMVVRPFLQSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMN6</accession>
    <name>F9UMN6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, DUF1312 famliy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888989.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1068"/>
    <dbReference type="EnsemblBacteria" id="CCC78475">
        <property type="protein sequence ID" value="CCC78475"/>
        <property type="gene ID" value="lp_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="57024721"/>
    <dbReference type="GeneID" id="66448977"/>
    <dbReference type="KEGG" id="lpl:lp_1068"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.902"/>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130936_1_1_9"/>
    <dbReference type="OMA" id="YNDKDHK"/>
    <dbReference type="PhylomeDB" id="F9UMN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-918-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="163" mass="18406" checksum="D92D7FB6FC477FE4" modified="2011-10-19" version="1">MRKLRTMIRTFKRYGDMIKPFDIIIIVALIILSFTPLAIFSYQQKQQAEHAALVAKRKATSSETTYNAVVSHNGTVLKRVNITNLKTTKHFTYRDNHGHYNTITFKPKRVAITKANCSDQVCVRRGWIHKPGQTIVCLPHKLLVEIKASNGQVKSGGNGLVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMU5</accession>
    <name>F9UMU5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ordered locus">lp_1144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1144"/>
    <dbReference type="EnsemblBacteria" id="CCC78534">
        <property type="protein sequence ID" value="CCC78534"/>
        <property type="gene ID" value="lp_1144"/>
    </dbReference>
    <dbReference type="GeneID" id="57024780"/>
    <dbReference type="KEGG" id="lpl:lp_1144"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.965"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_9"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="PhylomeDB" id="F9UMU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-976-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="755" mass="85091" checksum="0EDEE5ED9E6FBC0C" modified="2011-10-19" version="1">MSKESLLAGMNDKQQEAVLDTEGPLLIMAGAGSGKTRVLTHRVAYLIEEQGVNPWNVLAITFTNKAAREMRERVGKLLGESAQEVWVSTFHALCVRILRRDIEQIGYNRAFTIAGTSEQRTLVKRILTEQNIDSKKFDPRSILSAISNAKNDLQTPEMYKESAASPFESVVADVYLQYQRELAADQAVDFDDLIMLTIQLFKQNPETLAWYQNKFHYIHVDEYQDTNNAQYTLVNLLADKYKNLCVVGDADQSIYGWRGANMENILDFEKDYPQADTVMLEQNYRSTKTILSAANAVINNNSTRRPKKLWTENEPGDKISYYRGQSESDETHFVIAKIQESMQQDKMDYGDFAILYRTNAQSRVMEESLVKANIPYTMVGGNKFYDRKEIRDVLSYLTLAVNDQDSMNFERVVNEPKRGIGQTSVEKLRLFADEAGYSMLEAASNVDMANGISARAKGALAKFAATMNELRAMREYLSVTDLTQEILDRTGYMKALKDAKATKSLEAQARIENIEEFLSVTKQFDDSYQPEDEDSDKFVDFLADLALVSDVDNVEEEPQAVTLMTLHAAKGLEFPVVFLIGMEEGIFPLSRAMMDEDELEEERRLAYVGITRAEKKLYLTNAYSRMLYGRRQNNPASRFVEEIEPELLKNENTLDGASSTGPKVPFGADRERRAFTPSYKKNPVGTRATVKKASGTGADKNSWSIGDKVKHRKWGTGTVVKVSGAGEDAELDIAFKSEGIKRLLAAFAPIQKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV1</accession>
    <name>F9UMV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889054.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1150"/>
    <dbReference type="EnsemblBacteria" id="CCC78540">
        <property type="protein sequence ID" value="CCC78540"/>
        <property type="gene ID" value="lp_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1150"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.971"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-982-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="340" mass="36994" checksum="B2ED55D4803C855B" modified="2011-10-19" version="1">MRKRARLIYNPTSGREALAHDLVEILGIFEQAGYETSAFATTPAPNSAADEARRCAKDGFELIVAAGGDGTINQVVNGLAGLKRRPKMAIIPAGTTNDYARALRIPRNDPVAAAKVVLKNQTVKMDIGQAGEQYFINIAAGGMLTELTYDVPSQLKSIFGYAAYLAKGAELLPRVKPVEMDLKYDGGHYQGKASMFFLALTNSVGGFEQLVPDASLDDGKFTMIIVKTSNLAKMLHLMTLVLNGGKHINDPSIIYVKTSKVVAKPADKDRLMINLDGEYGGDAPMTFRNLKQHIEMFADTDRIPDEAITDTDPELEDAERHFVSAVDQLPAATEDDEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY2</accession>
    <name>F9UMY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase (Rhamnosyltransferase),family 2 (GT2)</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps1H</name>
        <name evidence="2" type="ordered locus">lp_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1184"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78571">
        <property type="protein sequence ID" value="CCC78571"/>
        <property type="gene ID" value="lp_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1184"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1002"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_1_9"/>
    <dbReference type="OMA" id="IKYRQHG"/>
    <dbReference type="PhylomeDB" id="F9UMY2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1014-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="308" mass="35720" checksum="9C9F22E33AF080EB" modified="2011-10-19" version="1">MSYNVAILMSTYNGMDYLREQIESIRSQTYKQWNLYIRDDGSSDNTIDLIKTFVHQDTRIHFINADKQVNRGVKRSFLNLLSSVKADFYMFCDQDDYWLPNKVKLTLDAMISDYHNKPRLVFTNMNLVDSNLKVLDKASLSAVNISYWTSKDQLMFDNIVTGCTVMINNQLKQYVFPISAKKIVMHDWYIAQLASQLGDIQYVTDPTILYRQHESNQVGVNKSLFGKVKKLARFNDFQTGVILQISQGRLTQKKSQVVFSKTTQAFLNWNFTCPLILKVLPIIQNNFKKHTWPGTIALNLALLRRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN00</accession>
    <name>F9UN00_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps2F</name>
        <name evidence="3" type="ordered locus">lp_1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101303.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889103.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1202"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78589">
        <property type="protein sequence ID" value="CCC78589"/>
        <property type="gene ID" value="lp_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1202"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1020"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_9"/>
    <dbReference type="OMA" id="INGCNEI"/>
    <dbReference type="PhylomeDB" id="F9UN00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1032-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="364" mass="41072" checksum="1885ABABEBCB4B3A" modified="2011-10-19" version="1">MKLVYVITQGGWGGAQAHVFDLISSAVQLNNQIWIICGSTGRLTDEIKHIFPKVHVIVLDDLCREVSFSHDLKAVMYLRRIFRRVKPDIIHLHSAKAGIIGRIAAYHISPVIYTVHGWAFTTGVSKKRALLAIAVERVLQPLTARYICVSKFDYNLGIKKGLMNKRHPGTVIHNGVRKEVFQHSLIKKHPTIVMAARFDVPKRQDLLIRALEKISDKSLHLILLGDGPKLLACQELANNLNIENRVHFLGSVTNVREYYADADIVMLISDYEALPISIIEGLASAKPIIASNVGGINELIQNNGFLVANSVNEIVQCVQLLLENRNLRNDMGQKSFEMFQNEYTERKMLSKTFNLYNSVMQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN18</accession>
    <name>F9UN18_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps3G</name>
        <name evidence="2" type="ordered locus">lp_1224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78607.1"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="106" mass="12194" checksum="DF13B02426FCDFC8" modified="2011-10-19" version="1">MVLGDATYFFIDSSFLNMLISYGLLLTLIIIIGMTWFLYQRTRQHDYLLPVIFVAIAISSMFDQHFLEVTYNVFILMLFADLPNYQTAVGPAFDQPVVIRRGASCR</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_1226"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023915_1_0_9"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
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        <property type="entry name" value="Acyl_transf_3"/>
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            <end position="204"/>
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    </feature>
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            <end position="322"/>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="129" mass="14376" checksum="0A9E590E1058010F" modified="2011-10-19" version="1">MQQPINYIMNIMHLERDLKRLTSNWSSATGLSLNELRILVYVEQHPGIQIGDVANALNVAKASLAQNIGTLITQGWLKSQPIKQDRRLRVLTLTKAGQDRMKDVDAQLTKSLDTTPATQLADQLSALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN57</accession>
    <name>F9UN57_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889160.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1268"/>
    <dbReference type="EnsemblBacteria" id="CCC78646">
        <property type="protein sequence ID" value="CCC78646"/>
        <property type="gene ID" value="lp_1268"/>
    </dbReference>
    <dbReference type="GeneID" id="57024886"/>
    <dbReference type="GeneID" id="66449143"/>
    <dbReference type="KEGG" id="lpl:lp_1268"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1077"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_33_1_9"/>
    <dbReference type="PhylomeDB" id="F9UN57"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1087-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="21485" checksum="EF02CAD0500875D1" modified="2011-10-19" version="1">MHYNVEPLRTDQEIDDFLWAVSQARYGERNRMIVLVGINTGLRMSDILRLKVGQVRGKDRVMIMEQKTGKKRWLFLKNLKTELAHFTRYRGANEPLFCSGRGGALTVNGVYRVFQTAGEYLERDDIGTHTLRKTFGYHYYQKTRDIAGLMMIFNHSSEQVTKRYIGIERDNLERQLWDFKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNE3</accession>
    <name>F9UNE3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889246.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78732">
        <property type="protein sequence ID" value="CCC78732"/>
        <property type="gene ID" value="lp_1388"/>
    </dbReference>
    <dbReference type="GeneID" id="57025029"/>
    <dbReference type="GeneID" id="66449232"/>
    <dbReference type="KEGG" id="lpl:lp_1388"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1163"/>
    <dbReference type="HOGENOM" id="CLU_162586_2_1_9"/>
    <dbReference type="OMA" id="EMNHRAV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1192-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="81" mass="9225" checksum="4D4A090DA7AEF2AB" modified="2011-10-19" version="1">MAVELKIGDYVAGKKFASLEHDFKGEIEKVYENSVLILIKEFQKADEPIVNEYNHRAVVRKDDAKLIKAAPKPKVVPEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNF3</accession>
    <name>F9UNF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system, beta-glucosides-specific EIIB component</fullName>
            <ecNumber evidence="5">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pts15B</name>
        <name evidence="5" type="ordered locus">lp_1399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643121.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1399"/>
    <dbReference type="EnsemblBacteria" id="CCC78742">
        <property type="protein sequence ID" value="CCC78742"/>
        <property type="gene ID" value="lp_1399"/>
    </dbReference>
    <dbReference type="GeneID" id="66449243"/>
    <dbReference type="KEGG" id="lpl:lp_1399"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1173"/>
    <dbReference type="eggNOG" id="COG1440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147323_2_1_9"/>
    <dbReference type="OMA" id="NGWDIAM"/>
    <dbReference type="PhylomeDB" id="F9UNF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1203-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="99" mass="10601" checksum="09CA29F81B9218C0" modified="2011-10-19" version="1">MKAINVLLVCAGGMSTSILMKKLQQYRDEQGVAGQIQAVGLSAYEDVYQDYDVILMGPQVAYRQGEVEAATGLPVAAIPPLDYAVGDSAHIFKLAENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNI7</accession>
    <name>F9UNI7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH peroxidase</fullName>
            <ecNumber evidence="5">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">npr1</name>
        <name evidence="5" type="ordered locus">lp_1445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78776">
        <property type="protein sequence ID" value="CCC78776"/>
        <property type="gene ID" value="lp_1445"/>
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    <dbReference type="KEGG" id="lpl:lp_1445"/>
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    <dbReference type="HOGENOM" id="CLU_003291_1_0_9"/>
    <dbReference type="OMA" id="KVMVPCG"/>
    <dbReference type="PhylomeDB" id="F9UNI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1237-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:cell redox homeostasis"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="323"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="438" mass="46984" checksum="1BB922BD61E19877" modified="2011-10-19" version="1">MAKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVTLFDQTTVTRITPATHTITARNQRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQNRASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGKQVTVIDVNARPFSHNLDSEFTQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRGTLALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNLLTDQRIVFPGVQATSALNAAGYYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLNATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMGATLEQLAYGDFFFQPGLSQPVDVLSTASLQALQTLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW3</accession>
    <name>F9UNW3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">lp_1586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644310.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889416.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78902">
        <property type="protein sequence ID" value="CCC78902"/>
        <property type="gene ID" value="lp_1586"/>
    </dbReference>
    <dbReference type="GeneID" id="57025172"/>
    <dbReference type="GeneID" id="66449470"/>
    <dbReference type="KEGG" id="lpl:lp_1586"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1336"/>
    <dbReference type="eggNOG" id="ENOG5030A24">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2155111_0_0_9"/>
    <dbReference type="OMA" id="YVLAVEF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1363-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="112" mass="12414" checksum="2DDEA3C59818CBBF" modified="2011-10-19" version="1">MKLEAIAGNIAHAIKDRSTDGPYVLAVEFTDKATKGKSATGCVIVRMPDHQHYTITSNDFRYMDADKDTLAEELGAFFECDDDLDQRQTLIDQVNDLVAQDADNDAQLMTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNW5</accession>
    <name>F9UNW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78904">
        <property type="protein sequence ID" value="CCC78904"/>
        <property type="gene ID" value="lp_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1590"/>
    <dbReference type="HOGENOM" id="CLU_1967763_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="127" mass="14370" checksum="432DD205AA0512F3" modified="2011-10-19" version="1">MQSSVSSPSLVAFNIIQTLLPKKMQAVSISLLPVMTVSQREFLSCTLALYNQSIKKELLIQDEQFFFNYLIFGVFSMVSVLPAAQRWIAATSFSRRMRFCFPATGRRDAHVLYGFATTVIRVCPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP05</accession>
    <name>F9UP05_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsY</name>
        <name evidence="10" type="ordered locus">lp_1633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101483.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889458.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1633"/>
    <dbReference type="EnsemblBacteria" id="CCC78944">
        <property type="protein sequence ID" value="CCC78944"/>
        <property type="gene ID" value="lp_1633"/>
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    <dbReference type="KEGG" id="lpl:lp_1633"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1380"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_2_2_9"/>
    <dbReference type="PhylomeDB" id="F9UP05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1407-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="9">
        <location>
            <begin position="207"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="305"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="306"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="313"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="395"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="459"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="512" mass="53587" checksum="51F1C884CA33B2EF" modified="2011-10-19" version="1">MGLFSRLKKAFSLPESDDAQTTSAASEAPATTSQANAPVSDDRAPSSQQLARSEGATTESTATPVSSTAVSEATSTADEPATVKSAATSEAPADSTAAVSAQSGSQASLQSATVSEAPLTASAMVAQSLAALSASAAQVSQAAASDVALATKSDAVVEGNAMSESVASTAPAVKSSATTATESAAPTVNAAADSESAEPEPTEAERYDEGLKKSRKTFGDRINAFLANFRHVDEAFFDDLEDTLIESDVGYETAMRISDELRDEVKLKNAKSKKEISSVIVEKLVDMYGEAGEGEDNSIHMAKSGPTVILFVGVNGAGKTTTIGKMANMYKQQGKKVLLAACDTFRAGAIQQLQVWGQRDGVDVVAKAEKSDPAAVCFDAVKKAKAEDYDVLFVDTAGRLQNKVNLMNELEKIKRVITREIPDAPHEVLLVLDATTGQNALNQAKLFKQSTDVSGIVLTKLDGTARGGIVLAIRNELHLAVKYVGLGEKVTDLRPFNANDFVYGLFKDIITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP58</accession>
    <name>F9UP58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645107.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78997">
        <property type="protein sequence ID" value="CCC78997"/>
        <property type="gene ID" value="lp_1695"/>
    </dbReference>
    <dbReference type="GeneID" id="66449562"/>
    <dbReference type="KEGG" id="lpl:lp_1695"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1431"/>
    <dbReference type="eggNOG" id="ENOG50301WG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205298_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1460-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7380" checksum="C3D3BEE0863FCF40" modified="2011-10-19" version="1">MDFIIAIGGLITGIGLIINVFNTRIKYGWFTHYQSKSRPLNYVSLLLIIIGLIIIIGKAYLNGQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP71</accession>
    <name>F9UP71_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640448.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889524.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1709"/>
    <dbReference type="EnsemblBacteria" id="CCC79010">
        <property type="protein sequence ID" value="CCC79010"/>
        <property type="gene ID" value="lp_1709"/>
    </dbReference>
    <dbReference type="GeneID" id="57025339"/>
    <dbReference type="KEGG" id="lpl:lp_1709"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1444"/>
    <dbReference type="eggNOG" id="ENOG5030AAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465157_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1473-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="10037" checksum="3842A00347DE3D9A" modified="2011-10-19" version="1">MTTLKYLRHSILIACFLNLIFALTHWAGIASDHLLIATNYGLSALIILMVLLNTIVLTHHPTIMLPQRQQIWLINFAALLIAFLTEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPF3</accession>
    <name>F9UPF3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF368 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889606.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1809"/>
    <dbReference type="EnsemblBacteria" id="CCC79092">
        <property type="protein sequence ID" value="CCC79092"/>
        <property type="gene ID" value="lp_1809"/>
    </dbReference>
    <dbReference type="GeneID" id="57025419"/>
    <dbReference type="KEGG" id="lpl:lp_1809"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1527"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_2_0_9"/>
    <dbReference type="OMA" id="LGLFDPM"/>
    <dbReference type="PhylomeDB" id="F9UPF3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1555-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="30888" checksum="D93DB9353EA9D881" modified="2011-10-19" version="1">MPTKTTDTFWKRFFKGVVIALGFILPGVSGGVLAAILGIYERLLGFMAHFRRNFKRDFWYFVPVGLGGIVGIALLSAPLEYLLAHAQVIVLWGFAGAIIGTLPALMKTATSRAPRDWLDGVWFFGTFIISAGLLYFMSELFGTLPANFGGFIVAGALIALGVLVPGLSPSNLLLILGLFTPMLTGFKRLDIVGVYLPIAIGGILAMALFSKLMDHLLVKFHSRVYHFILGIVLASTMLILIPNPYAAESISYAHATLSTYLFSAIALAVGIALGYWMSALESKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP5</accession>
    <name>F9UPP5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapE1</name>
        <name evidence="9" type="ordered locus">lp_1923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101593.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889698.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1923"/>
    <dbReference type="DNASU" id="1062174"/>
    <dbReference type="EnsemblBacteria" id="CCC79184">
        <property type="protein sequence ID" value="CCC79184"/>
        <property type="gene ID" value="lp_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1923"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1621"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_9"/>
    <dbReference type="OMA" id="STFEPTM"/>
    <dbReference type="PhylomeDB" id="F9UPP5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1646-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="175"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="381" mass="40795" checksum="BFCE16E1106B90BA" modified="2011-10-19" version="1">MRTIEDDAALKILADVIKIPSVNDHELTVAKYLQDLLAKYDISAKIHPITGDRANLVAEIGHGQPVLAVSGHMDVVAAGDLAAWDTDPFTLVEKSGQLFGRGVTDMKAGLVALVVAMINIQQQGGPKHGTIRLLATMGEEVGEAGSAAFYQQGAMQDAAGLLIAEPSTVYGTAAEQKGSCDLKLTSKGKAVHSSTPERGYNALVPLIKLLNEANDYFETIPAGEMGPVRFNIDVLNGGDQVNSLPDLATALVNVRTIPEYDNDQVTQKLADLIAAYNQQGADIKMTAIMNESPIATTADNRLVKLVQAIGKPYAGRDVVVASSPGITDASNLAKRQPADFPFAVYGPGNMTQHQVNESLPKQMFYDFIAIYQQLFTRFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR0</accession>
    <name>F9UPR0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889713.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1939"/>
    <dbReference type="EnsemblBacteria" id="CCC79199">
        <property type="protein sequence ID" value="CCC79199"/>
        <property type="gene ID" value="lp_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1939"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1636"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="TSWQALK"/>
    <dbReference type="PhylomeDB" id="F9UPR0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1661-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="33587" checksum="F37F413854CC8E14" modified="2011-10-19" version="1">MKAVIINQYGGPEELQMATIERPSIDQDEVLVAVQATSINPIDWKARQGLLKGMFDWQMPVVLGWDVAGTIVEAGAAVTNFKVGDEVFARPDIYADGRRGTYAEYAAVKEDKLALKPASLSFEQAAALPLAGLTAYQVIHDQLKIQAGEKVLIQAGAGGVGLNAIQIAKYLGAEVATTASANHHTLLRQIGADHVIDYHTTAIQDVLTDYDAVFDTIDAIDEALAILKPTGRLVTIDGQPTAAQKSQGPTVSSWWLQPNGRELAILGQLAVEGHLQVIIDQVFPFSTAGLQAAHRYSENSHSAGKLIINVGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR5</accession>
    <name>F9UPR5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645994.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889718.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1945"/>
    <dbReference type="EnsemblBacteria" id="CCC79204">
        <property type="protein sequence ID" value="CCC79204"/>
        <property type="gene ID" value="lp_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1945"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1642"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="MHTIIRT"/>
    <dbReference type="PhylomeDB" id="F9UPR5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1667-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="32397" checksum="3DA91F60A670937E" modified="2011-10-19" version="1">MTPLIEATKVAFSYGQQSVLTDINMTIMPGEIVGLIGENGAGKTTLLNLLLGIKRVQQGHLKVFGQAAGSLAARLKIGSMMQGDMTIQGVTVRDMLRLAAAQRLPEFDWQALLATLKLQDIAQQRLTALSGGQLRRVTFALALVGDPDLLFLDEPTVGMDTNAQQTFWQQIRRLKAAGKTIIITSHYLPEIEAIADRIMLLKDGRFVFQGSFAVLQKQYQQVEIRCQTRLPADRFTNLTAVTAVTKQGDELRMSSEDGDATLQAMMPIISELHQVSISRESLTDIFVHLTKGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW1</accession>
    <name>F9UPW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101620.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889764.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2002"/>
    <dbReference type="EnsemblBacteria" id="CCC79250">
        <property type="protein sequence ID" value="CCC79250"/>
        <property type="gene ID" value="lp_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2002"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1691"/>
    <dbReference type="eggNOG" id="ENOG5033W12">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122768_0_0_9"/>
    <dbReference type="OMA" id="GHVRHGL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1714-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="222" mass="24951" checksum="E5B2EC4BB47D1BDB" modified="2011-10-19" version="1">MYQLENLLKNQCDPRLSGVMSMAVRHASNSFDSLVASTPILQREEFRNTYGYLRHSFVDFSLKWAVNEHLIDGEIIPGTSSKYPNGHTYYSLKVKGAVINPVKTRGPKAIPKNALYRQELGLMNQQISLFDNIDDLMNKQINASAPAFLLLTYGGKNYSLDYIELGLPDVDTGKWIGQANILNAPLILPKHKTKEVTDKLDLTLTSISKKILEEENDGDYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ29</accession>
    <name>F9UQ29_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod-shape determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rodA1</name>
        <name evidence="7" type="ordered locus">lp_2078</name>
    </gene>
    <organism evidence="7 8">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101647.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889832.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_2078"/>
    <dbReference type="EnsemblBacteria" id="CCC79318">
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        <property type="gene ID" value="lp_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2078"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1760"/>
    <dbReference type="eggNOG" id="COG0772">
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    <dbReference type="OMA" id="TGMAMPF"/>
    <dbReference type="PhylomeDB" id="F9UQ29"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1778-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FtsW/RodA"/>
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        <property type="entry name" value="RodA/MrdB"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
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    <dbReference type="EMBL" id="AL935263">
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="OMA" id="KICEVFV"/>
    <dbReference type="PhylomeDB" id="F9UQ55"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1805-MON"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LPS_length_determ_N_term"/>
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        <location>
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            <end position="195"/>
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        <location>
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    </feature>
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            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC79344.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="27675" checksum="8A9F17045787D128" modified="2011-10-19" version="1">MEQVITFDFIVKLIRQYWKVLLSLMILGGTIATVVTLWVIQPEYQANVQILVNRKHSSAGADLTGQQADVQMITTYKELITKPVVLKPARQTLMAETDIRRSLESLKQTVSVTSTANSQVFSIGVRDKNAKASAMIANQIAATFKDQVQHIIKVNNVTIVAPAETPDQSVAPKKIINILIGFVGGLILGLVYASVRILSNRRVQTLEYLADELMLTSLGIINHQQPVTATHDQPAIEPQPVTSVVKAAVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ66</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2121</name>
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    <organism evidence="1 2">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889869.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2121"/>
    <dbReference type="EnsemblBacteria" id="CCC79355">
        <property type="protein sequence ID" value="CCC79355"/>
        <property type="gene ID" value="lp_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2121"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1796"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074772_1_0_9"/>
    <dbReference type="OMA" id="LFMDEQY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1816-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="304" mass="34316" checksum="6CA994D39FB3BEE0" modified="2011-10-19" version="1">MTIAETQLAAEQASRAQDWSKAASLWEQVYQAQQTAPVNYELVQALVADQQYVAAANYASEFEAQYLATDAAADLYLNALVANHDFISAHIMIKARPTSAWTTAANTTLKAAESTAERTLGSTLTTTMRHFYHLSDQPVQKQVAGLQAARHLPYERYLTAAKFLLVDPFLHPLTRVEVLYTLYQLQVSETVKMQWLLDEKMLTLCPAKLVALGQDETSKAVYHALKVRLGNQDVFLYESLRELLQLQLMYLYPCAAQVITDSTAWIDLLISLQTWQTITPSDDQTEKMMKIQQKIQQFSLDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQA9</accession>
    <name>F9UQA9_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ktrA</name>
        <name evidence="3" type="ordered locus">lp_2176</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101677.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889912.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2176"/>
    <dbReference type="EnsemblBacteria" id="CCC79398">
        <property type="protein sequence ID" value="CCC79398"/>
        <property type="gene ID" value="lp_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2176"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1839"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_2_9"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="PhylomeDB" id="F9UQA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1859-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="24292" checksum="CC98296D05814361" modified="2011-10-19" version="1">MRKSFAVFGLGRFGESVVRALAAAHQDVLAVDINEETVNELMDVATQTMIADTRDEQVLRDLNVDTFDYVIIGIGNNMEASILTTMLSKEQGAKKVIAKAETSDQGRVLERVGADQVVFPERDMGQGIAHRILSNHILNFIDLSDEYTLAAIEITDPNFVNQNLIDLKIRQRFGLTVIAIKHEKHIDVSPKPTDMMALHDVITVVGPVKGVIALDEALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB2</accession>
    <name>F9UQB2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine desulfurase associated protein,DUF1831 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2010" name="Acta Crystallogr. F Struct. Biol. Commun." volume="66" first="1205" last="1210">
            <title>Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.</title>
            <authorList>
                <person name="Bakolitsa C."/>
                <person name="Kumar A."/>
                <person name="Carlton D."/>
                <person name="Miller M.D."/>
                <person name="Krishna S.S."/>
                <person name="Abdubek P."/>
                <person name="Astakhova T."/>
                <person name="Axelrod H.L."/>
                <person name="Chiu H.J."/>
                <person name="Clayton T."/>
                <person name="Deller M.C."/>
                <person name="Duan L."/>
                <person name="Elsliger M.A."/>
                <person name="Feuerhelm J."/>
                <person name="Grzechnik S.K."/>
                <person name="Grant J.C."/>
                <person name="Han G.W."/>
                <person name="Jaroszewski L."/>
                <person name="Jin K.K."/>
                <person name="Klock H.E."/>
                <person name="Knuth M.W."/>
                <person name="Kozbial P."/>
                <person name="Marciano D."/>
                <person name="McMullan D."/>
                <person name="Morse A.T."/>
                <person name="Nigoghossian E."/>
                <person name="Okach L."/>
                <person name="Oommachen S."/>
                <person name="Paulsen J."/>
                <person name="Reyes R."/>
                <person name="Rife C.L."/>
                <person name="Tien H.J."/>
                <person name="Trout C.V."/>
                <person name="van den Bedem H."/>
                <person name="Weekes D."/>
                <person name="Xu Q."/>
                <person name="Hodgson K.O."/>
                <person name="Wooley J."/>
                <person name="Deacon A.M."/>
                <person name="Godzik A."/>
                <person name="Lesley S.A."/>
                <person name="Wilson I.A."/>
            </authorList>
            <dbReference type="PubMed" id="20944212"/>
            <dbReference type="DOI" id="10.1107/S1744309109023689"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2IAY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.20 A"/>
        <property type="chains" value="A=1-113"/>
    </dbReference>
    <dbReference type="PDBsum" id="2IAY"/>
    <dbReference type="SMR" id="F9UQB2"/>
    <dbReference type="STRING" id="220668.lp_2179"/>
    <dbReference type="DNASU" id="1062202"/>
    <dbReference type="EnsemblBacteria" id="CCC79401">
        <property type="protein sequence ID" value="CCC79401"/>
        <property type="gene ID" value="lp_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2179"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1842"/>
    <dbReference type="eggNOG" id="ENOG5032U9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169601_0_0_9"/>
    <dbReference type="OMA" id="IINGDNR"/>
    <dbReference type="PhylomeDB" id="F9UQB2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1862-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014965">
        <property type="entry name" value="Amino_acid_metab_prot_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035942">
        <property type="entry name" value="Lp2179-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08866">
        <property type="entry name" value="DUF1831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160800">
        <property type="entry name" value="SSF160800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2IAY"/>
        </source>
    </evidence>
    <sequence length="113" mass="12611" checksum="0D3C0304C87EA5DA" modified="2011-10-19" version="1">MAYTTTVKLDGDTKTYTLSPTVKKYTLMDLGFVKGRSGAFSFERSLDPTSPYQAAFKLKMTVNADLTGFKMTTVTGNGVQRANIFKNDAHPEAVEQLRYILANFIERDILTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR02</accession>
    <name>F9UR02_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2b protein 14, terminase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="11"/>
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    <evidence type="ECO:0000256" key="1">
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79665.1"/>
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    <dbReference type="EnsemblBacteria" id="CCC79665">
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    </evidence>
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    </evidence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2521"/>
    <dbReference type="EnsemblBacteria" id="CCC79685">
        <property type="protein sequence ID" value="CCC79685"/>
        <property type="gene ID" value="lp_2521"/>
    </dbReference>
    <dbReference type="GeneID" id="57025949"/>
    <dbReference type="KEGG" id="lpl:lp_2521"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2122"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_1_9"/>
    <dbReference type="OMA" id="TAFILME"/>
    <dbReference type="PhylomeDB" id="F9UR46"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2178-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="154" mass="17454" checksum="056579EA8ED2DA40" modified="2011-10-19" version="1">MDKTDLKILNALQADARISLKALADQCFISSPAISARITRLKKSGIIRDYQANLNFEKLNYHIKAYIQLQLEPTQKERFYPFVAGIPNILECDCITGEYSQILKVIFESTQALDEFVNQLQTFGKTSTQIVFSTSVPNRGLTLPDDHDMSKINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR56</accession>
    <name>F9UR56_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101816.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890209.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2534"/>
    <dbReference type="DNASU" id="1062726"/>
    <dbReference type="EnsemblBacteria" id="CCC79695">
        <property type="protein sequence ID" value="CCC79695"/>
        <property type="gene ID" value="lp_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2534"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2131"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_3_9"/>
    <dbReference type="OMA" id="WASELRY"/>
    <dbReference type="PhylomeDB" id="F9UR56"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2188-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="32976" checksum="BFE6BE556A3BC942" modified="2011-10-19" version="1">MKIAVVTESSANLKAQAVKDYQITVVNDPIMFGNHVYHENVDITTDQFYRLLKVEKEIPTISQISMPEMQVVFDQLQAAGYDQILVIGLSSGISGWINNLKTYAPSVDGIDVRVFDSRTACAGTANMVKLAAAMALADYTLDEIIAQLTRLRAATTTVLIVNSMRHLVKNGRIYNNSSLAGTMVLRNKPIITFNGHGKIQLLGKERTLKNAQQAVQDEFSQFVMNSQLPVRLDVISANDARIAEDWASELRYQFPAVRVKTGVIGPVLGVLTGDHALGMIWSLDWKPLLTTLNQEQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR82</accession>
    <name>F9UR82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890235.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2567"/>
    <dbReference type="EnsemblBacteria" id="CCC79721">
        <property type="protein sequence ID" value="CCC79721"/>
        <property type="gene ID" value="lp_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2567"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2157"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR82"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2213-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="19502" checksum="5FDA102EE24DEB29" modified="2011-10-19" version="1">MSYSIGQVADKLGVTIDTIRYYDKSGLLPFVKRNSIGRREFTDNDLHLMRTIVCLKNAGVSVADIATFIALRLEGDTTLNDRYQLLKTHEQELQQRITDLQDTMSYLKFKEWYYETATVAGHEDIHFVPGTNEVLPGLDQEYDAYLKATGQLVELSRFANVKDYRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URF8</accession>
    <name>F9URF8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp2</name>
        <name evidence="4" type="ordered locus">lp_2668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890311.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2668"/>
    <dbReference type="EnsemblBacteria" id="CCC79797">
        <property type="protein sequence ID" value="CCC79797"/>
        <property type="gene ID" value="lp_2668"/>
    </dbReference>
    <dbReference type="GeneID" id="66450335"/>
    <dbReference type="KEGG" id="lpl:lp_2668"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2236"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_1_9"/>
    <dbReference type="OMA" id="NDTWHRT"/>
    <dbReference type="PhylomeDB" id="F9URF8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2288-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="16082" checksum="3EDF0AE00E919184" modified="2011-12-14" version="1">MRQQLFGHHLDDLLKPTKLLKRAHREAENVLNAHVGMKTDVVEHDDDYTVTAELPGFDKDAITVKYADEWLTIRAHRSQDDRNDDGRVLHRERMDADFTRKFHLTNVVREEIQAHYQAGLLTVTLPKTVADSEGKIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9URK6</accession>
    <name>F9URK6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101897.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890359.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2732"/>
    <dbReference type="EnsemblBacteria" id="CCC79845">
        <property type="protein sequence ID" value="CCC79845"/>
        <property type="gene ID" value="lp_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2732"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2285"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053498_0_0_9"/>
    <dbReference type="OMA" id="SFEVHPF"/>
    <dbReference type="PhylomeDB" id="F9URK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2336-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="431" mass="47385" checksum="D9F19D0D68E9F3FB" modified="2011-10-19" version="1">MKLVGIAGSIEDKSYNRLLLKFIANHFSDMVDIEILDIQDVPMFNQSDDQTEGEAVQYLKRKIMQADGVIIATPEHNHTITAALKSVIEWLSFKIHPMSGKPVLIVGASYYDQGSSRAQLNLRQILESPGVDAVVMPGNEFLLGEVKQAFDDQNNLKDARTVSFLQETLGKFLKFVKMVNAMDAEAHADDWKNEDLEAKGEVETTIKGVNMHAADWVEQAAAKTHAAEGDDYVKLDRGVLTVNQLNWFLNSMPMELTYADANNQFLYYNHQMDGDKMLASRTPAQAGNPLADCHPKRAVPGVKRAVHMLRTGETDLFKLPVPGIPNKYVMHYYQALHDDKGEYKGINEFVLDLLPIVKYYLKQTGQMLAPDPDAKTDAVSGASSKAKETKPDAAPAVDDVSGASADTEAAPEAPTKPEAPDFDSVSGASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS4</accession>
    <name>F9URS4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein, membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642096.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890427.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2812"/>
    <dbReference type="EnsemblBacteria" id="CCC79913">
        <property type="protein sequence ID" value="CCC79913"/>
        <property type="gene ID" value="lp_2812"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2812"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2353"/>
    <dbReference type="eggNOG" id="COG4990">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067297_0_1_9"/>
    <dbReference type="OMA" id="PYGYKNR"/>
    <dbReference type="PhylomeDB" id="F9URS4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2409-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02549">
        <property type="entry name" value="Peptidase_C39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039563">
        <property type="entry name" value="Peptidase_C39_single_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016997">
        <property type="entry name" value="UCP032442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032442">
        <property type="entry name" value="UCP032442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="256" mass="28543" checksum="C88C3D46D32DF840" modified="2011-10-19" version="1">MPRHLRKRRRSWTLIIIAMVLLGVIGFTSTQVSDWIDASFTTKQTDAAKSSSQTKPKSVNQVKLDVPLVNQMTTPRLYNGCEVTSLTMLMNYAHINVTKNELAAKITSVPLTYSDGEHGNPEYGFVGDITGNDPGLGVYHKPIYKLAKTETSQVKDLTGANFDTVIEQLEQGRPVWTITTASFAPVSTMQTWQTPQGSVKVTYDMHSVVIVGFNRTKKLIYINNPYGEKQQAVSWKNFEAAYNQMGKQAIVLTLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS6</accession>
    <name>F9URS6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein, DUF554 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642100.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890429.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79915">
        <property type="protein sequence ID" value="CCC79915"/>
        <property type="gene ID" value="lp_2816"/>
    </dbReference>
    <dbReference type="GeneID" id="57026180"/>
    <dbReference type="KEGG" id="lpl:lp_2816"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2356"/>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_0_1_9"/>
    <dbReference type="OMA" id="DILMQAM"/>
    <dbReference type="PhylomeDB" id="F9URS6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2412-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="23482" checksum="03540704DF8BBB45" modified="2011-10-19" version="1">MIGTIFNTSMILAGCLVGSIFKKGIKPAYHAILLQALGLAACVIGINAVVQRMPQSKYPVLFIVSLAIGGLIGQALDIQGHFDRWVGRLAGGNLAEGLATAVLLYCIGSLSILGPIEAALKHDYTFLFTNGMLDGITSIVLASTFGFGIAIAAGVLFCWQGSLYVLALILKGALSAALLNEITIVGGILILASGLGMLKIKQFSTLNLLPALLVPPIVISVMQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URW2</accession>
    <name>F9URW2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thgA3</name>
        <name evidence="4" type="ordered locus">lp_2861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890465.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2861"/>
    <dbReference type="EnsemblBacteria" id="CCC79951">
        <property type="protein sequence ID" value="CCC79951"/>
        <property type="gene ID" value="lp_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2861"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2394"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_9"/>
    <dbReference type="OMA" id="RIKFVEF"/>
    <dbReference type="PhylomeDB" id="F9URW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2448-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="206" mass="22976" checksum="2F091608962835FD" modified="2011-10-19" version="1">MKTQKERMLSGELYVADDPELGRENHRAKRLVREFNQTTEAQPKERQRLLTAMFNKIGDGGYIEPPFHTDYGSNTTIGKHFYANYDAIFIDVGRITIGDNVFMGPRVGLYTAGHPIDAAIRAEQLEYGWPITIGHDVWFGGNVVVNPGVTIGSNVVIGSGSVVTHDIPDNVVAVGNPCHVLREITTADHEYWARQRAAYFADRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY1</accession>
    <name>F9URY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890484.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79970">
        <property type="protein sequence ID" value="CCC79970"/>
        <property type="gene ID" value="lp_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2883"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2413"/>
    <dbReference type="eggNOG" id="ENOG50308YB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2717370_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2467-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="72" mass="8163" checksum="DDE73BD86DC94973" modified="2011-10-19" version="1">MIEVKTVSRGNSLALSLPKDGRFKKGQRWLLIPSSDGESYTLVPRIENPYAGSKPKRPMTEAWSDVDWNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9US31</accession>
    <name>F9US31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101978.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890534.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2953"/>
    <dbReference type="ESTHER" id="lacpl-LP.2953">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="DNASU" id="1063407"/>
    <dbReference type="EnsemblBacteria" id="CCC80020">
        <property type="protein sequence ID" value="CCC80020"/>
        <property type="gene ID" value="lp_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2953"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2464"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048353_1_1_9"/>
    <dbReference type="OMA" id="IDDARCI"/>
    <dbReference type="PhylomeDB" id="F9US31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2516-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="249" mass="27009" checksum="0BC821ECB2790192" modified="2011-10-19" version="1">MTSMEFKIKRDGLALQARLETPAAPSSTLVILMHGFTADMGYDTTQFVPQLAQALVAHGLAVLRFDFNGHGCSEGRFQDMTVINEIADAKAVLDEALTLHYDHIVLAGHSQGGVVASMLAGYYPDVVDKLILMAPAATLKSDAQQGVLQGATYDPQHIPAYLNIRDGLKVGGFYLRTAQQLPIYEVAQQYAGSVTLIHVTADTVVSPQASEKYHEVYQHSQLHWVQDGGHRFSGDARATAIQLALAAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>F9US37</accession>
    <name>F9US37_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ordered locus">lp_0006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641632.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888098.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0006"/>
    <dbReference type="EnsemblBacteria" id="CCC77584">
        <property type="protein sequence ID" value="CCC77584"/>
        <property type="gene ID" value="lp_0006"/>
    </dbReference>
    <dbReference type="GeneID" id="57026868"/>
    <dbReference type="GeneID" id="66448162"/>
    <dbReference type="KEGG" id="lpl:lp_0006"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.5"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_9"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="PhylomeDB" id="F9US37"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-5-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="432"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC77584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="648" mass="72125" checksum="568D6F40C041658C" modified="2011-10-19" version="1">MTENEKETKLEQAREYDASQIQVLEGLEAVRKRPGMYIGTTSSQGLHHLVWEIVDNGIDEALAGFANVIHVTVEKDNSITVTDNGRGIPVDIQEKTGKPALETVYTILHAGGKFGGGGYKVSGGLHGVGASVVNALSSTLDVKVTRNGHVYYMDFERGKVKTPMKIIGDAPDDAHGTAVHFVPDPDIFRETTTYDINILTTRIRELAFLNKGLRITIRDNRPDEPTEDDFLYEGGIRHYVEYLDKNKTVLFPEPIYVEGEQNGITVEVALQYTDDYHSNLMTFTNNIHTYEGGTHEEGFKRALTRVINDYARKNNLLKESDANLSGEDVREGMTAVVSVKHPDPQFEGQTKTKLGNSDARAAVDRLFSEHFSKYLMENPSVARKVVDKGLLASKARVAAKRAREVTRKKSGLEISNLPGKLADNSSKDPEISELFIVEGDSAGGSAKQGRSRLTQAILPIRGKILNVEKASIDKILANEEIRSLFTAMGTGFGGDFDLSKANYHKLIIMTDADVDGAHIRTLLLTLFYRYMRPLVDAGFVYIAQPPLYQVRQGKFVKYIDSDEELSEVMGQLAPSPKPVVQRYKGLGEMDAEQLWETTMDPDKRRLLRVRDEDAADADGVFSMLMGDQVKPRREFIEDNAKFVQDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9US63</accession>
    <name>F9US63_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of two-component system, YycH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888124.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0038"/>
    <dbReference type="EnsemblBacteria" id="CCC77610">
        <property type="protein sequence ID" value="CCC77610"/>
        <property type="gene ID" value="lp_0038"/>
    </dbReference>
    <dbReference type="GeneID" id="57026896"/>
    <dbReference type="GeneID" id="66448189"/>
    <dbReference type="KEGG" id="lpl:lp_0038"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.32"/>
    <dbReference type="eggNOG" id="COG4863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037125_1_0_9"/>
    <dbReference type="OMA" id="REFNRFF"/>
    <dbReference type="PhylomeDB" id="F9US63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-32-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009996">
        <property type="entry name" value="YycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042274">
        <property type="entry name" value="YycH/YycI_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07435">
        <property type="entry name" value="YycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YycH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="441" mass="50161" checksum="E85A58C644FD2159" modified="2011-10-19" version="1">MTTHKLRRFILPILLTILILLSVVLSMYIWLNPSRYEHESKVSTTSSNSSLTTRTIDDIYLPTQLIHTNSQGGQSLLINKNVSLVSQFSEQLRKWDARSISKVRITSAKSYRALLNGTDSYVLNFPDSITVSMFNTVFKQHLSNFRSSEFSRIVIPVNDTNHIYFLNDDHHEIYSVRLKKKSLSSLKKVLAVDKVKRIAVKMTYEDNTTYIDYPKQVTMQHYSYLMSKAAASEIANRLLDADGNSTVSVHNRSGKQEYTTGSYKRMTVDSKLGTVYFEDYSDSGTTRNLSLTNQLKKSFNLLTSLGVPMDNIRYYGFDATSNSVIYRSYVEGFPIFNQTENGDVRIQLTSNGLDRYYFSLYSLQVPVPTTGQKQAVTLPSSTSVLKRLKAAGYKDSKIGSIELGYEWSQNKSSKLVIDLTPTYYVYYNGTWRTYTSMLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US92</accession>
    <name>F9US92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tannase (Tannin acylhydrolase)</fullName>
            <ecNumber evidence="2">3.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tanL</name>
        <name evidence="2" type="ordered locus">lp_2956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890536.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US92"/>
    <dbReference type="STRING" id="220668.lp_2956"/>
    <dbReference type="ESTHER" id="lacpl-tanL">
        <property type="family name" value="Tannase_Bact"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80022">
        <property type="protein sequence ID" value="CCC80022"/>
        <property type="gene ID" value="lp_2956"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2956"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2466"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007377_0_0_9"/>
    <dbReference type="OMA" id="AYEWEFN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2518-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050318">
        <property type="term" value="F:tannase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="469" mass="50748" checksum="B1C11A31B892BB40" modified="2011-10-19" version="1">MSNRLIFDADWLVPEQVQVAGQAIQYYAARNIQYVQHPVAAIQVLNVFVPAAYLHGSSVNGYQRATAPILMPNTVGGYLPGPADDPQRVTWPTNAGTIQQALKRGYVVVAAGIRGRTTVDKSGQRVGQAPAFIVDMKAAIRYVKYNQGRLPGDTNRIITNGTSAGGATSALAGASGNSAYFEPALTALGAAPATDDIFAVSAYCPIHNLEHADMAYEWQFNGINDWHRYQPVAGTTKNGRPKFEPVSGQLTVEEQALSLALKAQFSTYLNQLKLTASDGTHLTLNEAGMGSFRDVVRQLLISSAQTAFDQGTDIHKYAGFVVTGNQVTDLDLSAYLKSLTRMKAVPAFDQLDLTSPENNLFGDATAKAKHFTALAQTRSTVTAQLADAELIQAINPLSYLTTTSSRVAKHWRIRHGAADRDTSFAIPIILAIMLENHGYGIDFALPWDIPHSGDYDLGDLFSWIDGLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE5</accession>
    <name>F9USE5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643364.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890589.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3018"/>
    <dbReference type="EnsemblBacteria" id="CCC80075">
        <property type="protein sequence ID" value="CCC80075"/>
        <property type="gene ID" value="lp_3018"/>
    </dbReference>
    <dbReference type="GeneID" id="57026345"/>
    <dbReference type="GeneID" id="66450612"/>
    <dbReference type="KEGG" id="lpl:lp_3018"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2521"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_0_0_9"/>
    <dbReference type="OMA" id="HAAYDYL"/>
    <dbReference type="PhylomeDB" id="F9USE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2569-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="297" mass="32939" checksum="CA9B6B44A4DB317D" modified="2011-10-19" version="1">MKRLWLLLGGLVIGGGLLTGCQSKSTTAESHKVNIVATTNFYGSVAKAVGGKHVSVTSIINKPSVDPHDFEPTPTVAKTVGQADLVIANGIGYDGWMNKVVHSTQRAKLIRVGEDVMHRKEGANEHLWYDSATMPATANYLANQLAKKQPQYRTYFKANARKYIATLKPIQQEQAKLRAKANKLKNRQVLVSEPVFDYALTSLGFKVANQDFENAIEKGTDPAPQVIHKMQQALKSRQVAFFVNNSQVSDKLVTNMVSLAKKNQVPVLNVTETMPAKLTYQQWMLAQYRQLNQLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ0</accession>
    <name>F9USQ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642382.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890694.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3141"/>
    <dbReference type="EnsemblBacteria" id="CCC80180">
        <property type="protein sequence ID" value="CCC80180"/>
        <property type="gene ID" value="lp_3141"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3141"/>
    <dbReference type="eggNOG" id="ENOG5030IF0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186709_0_0_9"/>
    <dbReference type="OMA" id="YYIRSRK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2673-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024229">
        <property type="entry name" value="DUF3781"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12636">
        <property type="entry name" value="DUF3781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="91" mass="10638" checksum="15789F036EB55A9D" modified="2011-10-19" version="1">MSKQSVILELIRTHICYTPRVFQRINKKLAVNLSEVEIKDLVNHILIQPDEIKRCGKNYYIRSRKARIELTVNAGNYRLITASKYTEVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU8</accession>
    <name>F9USU8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress-responsive transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641730.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888193.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0126"/>
    <dbReference type="EnsemblBacteria" id="CCC77679">
        <property type="protein sequence ID" value="CCC77679"/>
        <property type="gene ID" value="lp_0126"/>
    </dbReference>
    <dbReference type="GeneID" id="57026966"/>
    <dbReference type="GeneID" id="66448262"/>
    <dbReference type="KEGG" id="lpl:lp_0126"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.103"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143433_5_0_9"/>
    <dbReference type="OMA" id="NDKWIAG"/>
    <dbReference type="PhylomeDB" id="F9USU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-101-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="64" mass="7234" checksum="0F2D7878B306A296" modified="2011-10-19" version="1">MKIDIHRSATDRVIAGVIGGIAEHFNWNTNVTRLLFVVLAITPMFPGIIAYLILWLLMKDPIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USU9</accession>
    <name>F9USU9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100896.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888194.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0127"/>
    <dbReference type="EnsemblBacteria" id="CCC77680">
        <property type="protein sequence ID" value="CCC77680"/>
        <property type="gene ID" value="lp_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0127"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.104"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_9"/>
    <dbReference type="OMA" id="DTVSFHN"/>
    <dbReference type="PhylomeDB" id="F9USU9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-102-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="22261" checksum="09D0C16C981B7E1D" modified="2011-10-19" version="1">MFKIAIILGSTRSQANGRALLNHLKLIIDQLPTHSPIHYQFLDLANYQLPFFDEPEPPMANPHRELPANQQQWLTDMASADGYIILTPEYNHAMPAGLKNAFDFLAFEGARKPAKIISYSDNMRGGQFGAAALVPVLQRLGIVVLPKPTPIGNVPQTLQSNGHFIDNAPLSKRYDHTLHQALTEITYYTTVLTTTPFPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV1</accession>
    <name>F9USV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp1</name>
        <name evidence="4" type="ordered locus">lp_0129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100898.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888196.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0129"/>
    <dbReference type="EnsemblBacteria" id="CCC77682">
        <property type="protein sequence ID" value="CCC77682"/>
        <property type="gene ID" value="lp_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0129"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.106"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_1_9"/>
    <dbReference type="OMA" id="KNYIHRE"/>
    <dbReference type="PhylomeDB" id="F9USV1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-104-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="140" mass="15999" checksum="18EA32A74205A763" modified="2011-12-14" version="1">MANTLMNRNDFGMLDPFERMARSFWAPLENMDQVLKTDINETDDQYQVKVDVPGIDKQDVKLDYRDNVLSIKVQKDSFVDHEDQDQNIVMNERHTGTLQRQYMLPNVAANKITASQADGVLTITLPKTQPSANDGQIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT17</accession>
    <name>F9UT17_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ack1</name>
        <name evidence="6" type="synonym">ackA</name>
        <name evidence="8" type="ordered locus">lp_0210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641803.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0210"/>
    <dbReference type="EnsemblBacteria" id="CCC77748">
        <property type="protein sequence ID" value="CCC77748"/>
        <property type="gene ID" value="lp_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0210"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.174"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_9"/>
    <dbReference type="OMA" id="PLHNPME"/>
    <dbReference type="PhylomeDB" id="F9UT17"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-170-MON"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="395" mass="42892" checksum="B78BC95FC757BC5F" modified="2011-10-19" version="1">MQKTLIINAGSSSLKWQLFAMPAETVVASGLVERISMPGSIFTIKYGDHQKFETTVDNLDQNHAAQMLLAELQRLAIIDSLTEITAVAHRVVAGGETFKQAVEVTPAVLEAIKGLSDFAPLHNPMEARGIETMAQALPTVKQYAVFDSQFFTDLPEMNAIYSLPYELTQKYHIRRYGEHGISHGYLTGRAAELLAKPKDDLNLVTLHLGSGASLAAVKNGRAFDTSMGFTPLTGVTMGTRAGDVDPAVLPFLMKALKIDDPNEIMMMLNNQSGLLGISGISPDMREIRAQEATNPQAQLAVEIFVNRIVKYAGSYLTELKRADALIFAGGIGEHNATLRQQIIDELSIFGVTLDPKLNEAGQEGLISGADSKIKVMLIPTNEELAMVRQVAALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT36</accession>
    <name>F9UT36_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100928.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888281.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77767">
        <property type="protein sequence ID" value="CCC77767"/>
        <property type="gene ID" value="lp_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0235"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.195"/>
    <dbReference type="eggNOG" id="ENOG50309TG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473428_0_0_9"/>
    <dbReference type="OMA" id="RPADNSH"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-189-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="20090" checksum="30844AC017341EC0" modified="2011-10-19" version="1">MSTQTISPEQDSELVASVAAEQLGIKAVTLRKYSTMVEKQLNDENRFRPADNSHRLYTAADLKTFQAAIELAEQGTTLATALGRAFGAKVPTSKKPAATTTQSEKSAPATTTKSPLITTTTVDPSKMAPAAKPDGPTNAELYKQQEMIIRRLDSLSDRLNQVLDQLDQQASQAAKPWWHFWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT50</accession>
    <name>F9UT50_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100938.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888295.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0252"/>
    <dbReference type="EnsemblBacteria" id="CCC77781">
        <property type="protein sequence ID" value="CCC77781"/>
        <property type="gene ID" value="lp_0252"/>
    </dbReference>
    <dbReference type="GeneID" id="57027071"/>
    <dbReference type="KEGG" id="lpl:lp_0252"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.208"/>
    <dbReference type="eggNOG" id="ENOG502Z844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098610_0_0_9"/>
    <dbReference type="OMA" id="IAMLKDM"/>
    <dbReference type="PhylomeDB" id="F9UT50"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-203-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010763">
        <property type="entry name" value="DgaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07071">
        <property type="entry name" value="KDGP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03581">
        <property type="entry name" value="EF_0839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="244" mass="25341" checksum="D6514134FCBB91A4" modified="2011-10-19" version="1">MQLTPNYLPNGICLNVLANSVTNAEACYAAAEGHVVLGVLTKNYLSDESAITDMRRYQAAVNNAVSVGLGAGSPQQSAMVARVAAEIQPQHVNQVFTGVATSRALLGQADTVINGLVAPSGEVGLVNVATGPLSSQSAKANIPVATAITMLKDMGGTSLKYFPMQGTAHLEEFKAVAAACADNEFGLEPTGGLDLTNFQQIVQIAVAAGVRQIIPHVYSSIIDATTGETQPEAVAQLLTIMKQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT68</accession>
    <name>LPDD_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LpdD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gallate decarboxylase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lpdD</name>
        <name evidence="5" type="ordered locus">lp_0272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Appl. Environ. Microbiol." volume="79" first="4253" last="4263">
            <title>Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation.</title>
            <authorList>
                <person name="Jimenez N."/>
                <person name="Curiel J.A."/>
                <person name="Reveron I."/>
                <person name="de Las Rivas B."/>
                <person name="Munoz R."/>
            </authorList>
            <dbReference type="PubMed" id="23645198"/>
            <dbReference type="DOI" id="10.1128/AEM.00840-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probably involved in tannin degradation, however the precise biochemical function in metabolism of gallate is unknown.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1">Cells lacking this gene are able to decarboxylate gallic acid and protocatechuic acid.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Gallate decarboxylase does not form a complex composed of Lpdc, LpdB and LpdD. The term subunit has been used in reference to the three-gene operon. Gallate decarboxylase LpdC is the only protein required to yield the gallate decarboxylase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888313.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UT68"/>
    <dbReference type="STRING" id="220668.lp_0272"/>
    <dbReference type="EnsemblBacteria" id="CCC77799">
        <property type="protein sequence ID" value="CCC77799"/>
        <property type="gene ID" value="lp_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0272"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.226"/>
    <dbReference type="eggNOG" id="ENOG5033YIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139132_1_0_9"/>
    <dbReference type="OMA" id="PHIGDVT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-221-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-19904"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444027" description="Protein LpdD">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23645198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="136" mass="15030" checksum="A173DDF26F93635B" modified="2011-10-19" version="1">MATFTTEQAGYQMQAILQVIGYDLLIVVTGGTNPHIGDVTTLTASTVPETVKFPSHDGRFHKDNFISERMAKRIQRYLAGSCTITAGIHVNQITKAQIAAAAPMTDDLSRQIISWLQAHPVQAEKPEYYGQDEQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT72</accession>
    <name>F9UT72_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5 diketo-D-gluconic acid-like reductase (C-terminal), NADP dependent, (Promiscuous)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.342242956"/>
    <dbReference type="EnsemblBacteria" id="CCC80190">
        <property type="protein sequence ID" value="CCC80190"/>
        <property type="gene ID" value="CCC80190"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3156"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_12_0_9"/>
    <dbReference type="PhylomeDB" id="F9UT72"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="20426" checksum="7422FC6EE22A7090" modified="2011-10-19" version="1">MIHQPLGDVYGSWRAMEAAYHDGQLKALGVANFENDRLQDLIMHNEVKPTVDQIELHPFYQQPQRVQWLLNHDIVPEAWGPFAEGKKGIFTNSAIQEIAEAHGKTNGQIILKWLNQRNIVVIPKSVHAARIVENSQIFDFELTQDEMQQMTKLDEGTSLFGNMHDPETVAQLGGFKFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT81</accession>
    <name>F9UT81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642403.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3168"/>
    <dbReference type="EnsemblBacteria" id="CCC80199">
        <property type="protein sequence ID" value="CCC80199"/>
        <property type="gene ID" value="lp_3168"/>
    </dbReference>
    <dbReference type="GeneID" id="57026461"/>
    <dbReference type="KEGG" id="lpl:lp_3168"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2752796_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="70" mass="8309" checksum="BAF5F92776C86D1D" modified="2011-10-19" version="1">MFSAKIKQQVLSKYLQGNSSLLLMKEYGIKGSATIYQWLTQFEIFGIQGLENCRRKTFYDYSFKIKVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA0</accession>
    <name>F9UTA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp11</name>
        <name evidence="8" type="ordered locus">lp_3191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890732.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3191"/>
    <dbReference type="EnsemblBacteria" id="CCC80218">
        <property type="protein sequence ID" value="CCC80218"/>
        <property type="gene ID" value="lp_3191"/>
    </dbReference>
    <dbReference type="GeneID" id="57026480"/>
    <dbReference type="KEGG" id="lpl:lp_3191"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2666"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="OMA" id="QLWGYPP"/>
    <dbReference type="PhylomeDB" id="F9UTA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2706-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="229" mass="25781" checksum="77A4DB4D276931CB" modified="2011-10-19" version="1">MKILVVDDDKEIAQLLEIYIKNEGYEPISAYNGREALTKLNTNPDIALMILDIMMPEMDGIEVIKEVRKDSQLPILVLSAKTGDMDKIQGLITGADDYVTKPFNPLEIMARVKSLLRRSENNVTTTEPDILDIGPLTINKDSHEVKTLTGKDIQLTALEFGILYLLASHPNRVFSADDIFERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIQTVWGVGYKIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTF7</accession>
    <name>F9UTF7_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Dehydrosqualene synthase</fullName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtM</name>
        <name evidence="5" type="ordered locus">lp_3263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642485.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890789.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3263"/>
    <dbReference type="DNASU" id="1061861"/>
    <dbReference type="EnsemblBacteria" id="CCC80275">
        <property type="protein sequence ID" value="CCC80275"/>
        <property type="gene ID" value="lp_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3263"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2724"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_3_9"/>
    <dbReference type="OMA" id="KLYCYRV"/>
    <dbReference type="PhylomeDB" id="F9UTF7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2763-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="293" mass="33453" checksum="DB63A60DCD7CC50E" modified="2011-10-19" version="1">MTKLMPKFEQHRTDFAYCQTITKRSSSAFYTAFSQLPLERAWSIYAVYAFCRTADDLVDVDHDIDGLMALRQSLTTFANGHVPDHPMWRALAVVFETYDMNLDVFFDMLTGQEQDATFKQPQTQQALEDYCYYVAGSVGLMILPMLATNPQSLVKPAVELGSAMQLTNILRDVGEDYQRGRIYLPSKLLAHYQLNPTDLHGPIPSANFIRLWEHEAQIAMNKYEAALTMMPQIDPVARPSLLAATLLYRELLLIAREQHYPILSQRVFLTDERKTQVLNQVSTKVHELALKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ7</accession>
    <name>F9UTQ7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888341.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0302"/>
    <dbReference type="EnsemblBacteria" id="CCC77827">
        <property type="protein sequence ID" value="CCC77827"/>
        <property type="gene ID" value="lp_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0302"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.255"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077123_1_0_9"/>
    <dbReference type="OMA" id="ESAVYMT"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-249-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394335" evidence="2">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="267" mass="26309" checksum="7C05CCCB0FD4EDF8" modified="2011-10-19" version="1">MKIKNLVLSSTAALALFAISTTVANADTYTVKAGDTVSAIAQAHNTSVSAIEKANKLANVNLIFIGDKLEVNGTTTTTTTSTATSAAPQSATSQATSSAASTATSASATSASSQSVASQATSSAATASAASQATSSVATSAASSASSTQSAASQASSSAATTSQASSSATSSAASSTASTTSTTSSYTGSNLKSYVLSQMQSRTGVSASTWNTIITRESNWNSTVKNSTSGAYGLFQNMHISSGSVEDQVNAAVSLYNAQGMAAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ6</accession>
    <name>F9UTZ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin immunity protein PlnM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnM</name>
        <name evidence="2" type="ordered locus">lp_0409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641974.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0409"/>
    <dbReference type="EnsemblBacteria" id="CCC77916">
        <property type="protein sequence ID" value="CCC77916"/>
        <property type="gene ID" value="lp_0409"/>
    </dbReference>
    <dbReference type="GeneID" id="57024214"/>
    <dbReference type="KEGG" id="lpl:lp_0409"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.335"/>
    <dbReference type="eggNOG" id="ENOG5030AQB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196714_0_0_9"/>
    <dbReference type="OMA" id="YQLFTAY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-339-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7262" checksum="D738388EE05F7BB3" modified="2011-12-14" version="1">MLERITGFIIICFAIWQIYTAYLAFKQVKQVGNKSTSPFIALGVWSGLSFGILMVAFGIALAFNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU42</accession>
    <name>F9UU42_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642020.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888476.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0459"/>
    <dbReference type="EnsemblBacteria" id="CCC77962">
        <property type="protein sequence ID" value="CCC77962"/>
        <property type="gene ID" value="lp_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="57024257"/>
    <dbReference type="GeneID" id="66448535"/>
    <dbReference type="KEGG" id="lpl:lp_0459"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.379"/>
    <dbReference type="eggNOG" id="COG4466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153735_1_0_9"/>
    <dbReference type="OMA" id="NIFVVKF"/>
    <dbReference type="PhylomeDB" id="F9UU42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-383-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009366">
        <property type="entry name" value="Protein_Veg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40026">
        <property type="entry name" value="PTHR40026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06257">
        <property type="entry name" value="VEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037257">
        <property type="entry name" value="DUF1021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9466" checksum="8D1A8FC235BD6FDE" modified="2011-10-19" version="1">MPISLAAIKDKLDSRIGQRMKVVAQAGRKKTTERHGILKETYRSVFVVDLDQQENAFERVSYSYTDVLTKNVQIAFDDETTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU49</accession>
    <name>F9UU49_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">copB</name>
        <name evidence="7" type="ordered locus">lp_3363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890865.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3363"/>
    <dbReference type="EnsemblBacteria" id="CCC80351">
        <property type="protein sequence ID" value="CCC80351"/>
        <property type="gene ID" value="lp_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3363"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2804"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_9"/>
    <dbReference type="OMA" id="MALEPMG"/>
    <dbReference type="PhylomeDB" id="F9UU49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2840-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="679" mass="72211" checksum="6FB57EB94321C8F3" modified="2011-10-19" version="1">MKDMDMQHMAHHDSNDMGDMDMGNGEMMHMGNLKLKFWVALVLTIPIIIMSPMMGVNLPFQIVFRPWSDYIVAILGTILFLYGGQPFFSGAKAEVKNHKPAMMTLITMGISVAYVYSIYAVVANGLLNAKPMVTDFFWELATLIVIMLLGHWIEMNTVMNAGSAVDKLAKLLPSTAHKLVDGQVHDVAIADLANGDQVQVRAGEQIPADGTVLNGATSVNEAMVTGEAKLVEKRAKDQVVGGSVNGDGTFEMKVTGTGESGYLAQVMKLVSDAQAAKSSQENMADKVAGLLFYAALTVAIVAFIVWLLVGNLALALSIAVTVLVIACPHALGLAIPLVVARSTAIAASHGLLIRNRDAMEQVKKLNYALMDKTGTLTAGNFKVADYQSSAYRLTADAVLAMMAGLENGSSHPLAVGILAAAKEHQLTPKVSQDVHQITGVGLSGTIDGQTYQIVSAAYLDKQNLAYDQQTFNRLASAGNSVSFLIQEQTVLGFVAQGDQIKPEAKNLIDSLKAQNITPVMLTGDNPQSAQVVAKQLGITEVHAGLLPEDKAKLVQQYQADGSHVMMIGDGVNDAPSLARADIGVAIGSGTDVAIDSADIVLVKSNPNDVVDFLALARRTTRKMAQNLWWGAGYNVITIPLAAGILAPLGFILNPMFGAVVMSLSTVIVAINAMTLRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU70</accession>
    <name>F9UU70_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P3 protein 3, phage-like repressor,C-term domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_3388a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890886.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3388a"/>
    <dbReference type="EnsemblBacteria" id="CCC80372">
        <property type="protein sequence ID" value="CCC80372"/>
        <property type="gene ID" value="lp_3388a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3388a"/>
    <dbReference type="eggNOG" id="COG3646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1720034_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UU70"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2860-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="152" mass="17532" checksum="004E78A0AF5EB7B8" modified="2011-10-19" version="1">MLLITYLGNTKPVRQFKKALIKQFSDMKRELILRQAKFELGKEFSKSLHEAIRESPALGEHGHLYVNINKLVYKQALGVNVNELRKARNIPKTEAITHYLSSSEADAVKRVKQQIRTLLEMKMDYQQVKQALQIQGVIYRIELQLPAKASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUC0</accession>
    <name>F9UUC0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endopeptidase PepO</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pepO</name>
        <name evidence="10" type="ordered locus">lp_3445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890936.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3445"/>
    <dbReference type="EnsemblBacteria" id="CCC80422">
        <property type="protein sequence ID" value="CCC80422"/>
        <property type="gene ID" value="lp_3445"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3445"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2870"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_9"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="PhylomeDB" id="F9UUC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2910-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="445"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="638" mass="71922" checksum="AE483AC62A965E4A" modified="2011-10-19" version="1">MATINQAAVKQDLYDAVNGEWLKTAVIPDDHSSTGGFMDLVDAIEKTLMHDFDAMAAGTVTPDDPQLTEFIKFYRLAKDFDQRNANGAEPILPCLKQIDSLSDFADLQQRMPDWIYDGLPLPFSLDVDADMKNTKVNALFAQAPGTILPDKTYYDEGNQAGPKLLAIYAKMMTELLQKTGYEKDEAQKIVDDTLQFDRLIVPWIKSAEESADYSKMYNPRKFNDFVNTSRYLDLAAITYSVIDGNPDLVILPEPAFFDHFNEVVNPDNFGLMKNWMKAKLVQRYSGYLSDEMRVLATTYSRALSGQKEPRNQAKSAYYLATGTFDQVVGLYYGHKYFGEAAKADVHQMVEKMIAVYKRRLQVNTWLSADTRAKAVTKLDKLGIQVGYPDKLETIYTKFKTHTPEQGGNVLSNVLHFNRLARQDMFSKWGKATDRTRWEMSADTVNAYYHPFMNIIVFPAAILQAPFYSLEQSSSANYGGIGAVIAHEISHAFDNNGALFDEFGNLHNWWTEEDSAHFKELAKSMISEFDGLDFAGAKVNGTLTVSENIADAGGLSCAEEAAKGEDDVDLSAFFTNWAMVWRMKATTEYMQLLLSIDVHAPAKLRANVQPKNLDDFYTTFDIQPDDAMYLAPDKRVKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD5</accession>
    <name>F9UUD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS regulated carbohydrate transporter, GPH family, lactose (Can switch between symport (H+) and antiport (Galactose))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lacS</name>
        <name evidence="15" type="ordered locus">lp_3468</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the sodium:galactoside symporter (TC 2.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643048.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890951.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3468"/>
    <dbReference type="EnsemblBacteria" id="CCC80437">
        <property type="protein sequence ID" value="CCC80437"/>
        <property type="gene ID" value="lp_3468"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3468"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2885"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_1_0_9"/>
    <dbReference type="OMA" id="YASFCLG"/>
    <dbReference type="PhylomeDB" id="F9UUD5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2925-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018043">
        <property type="entry name" value="Na/Gal_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00872">
        <property type="entry name" value="NA_GALACTOSIDE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="14">
        <location>
            <begin position="514"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="648" mass="69875" checksum="8CA3487EB914D9D0" modified="2011-10-19" version="1">MAQNVEQQPVTKKKLSWHQINEGVAFGLGNLGHSAFYGALSTYFIVFVTSGMFSGVAPAIANRLIGLITGLVVVIRLAEVVVDPILGNIVDNTETRWGKFKPWQVIGSIISSVLLVVIFSGIFGLAKVNWILFAIVFVILFIILDVFYSLTDVSYWGMVPAISEDSHARGIFTALGSFTGTIGWNGLTMVVVPITTYFTFIATGKHTQGPQGWLAFAVIVGIVAVISALFVAFGTSEKHNAIREAAKQKTTIKGVFMGIIKNDQIMWVSLGYLFYSLAYVTTNGVLFYLFKFVIGKPGEFWIAGAVATVIGFVTSPLYPILNRFIPRKVLFALGQCSMILAYIIFIVAQTNLTLLIIGLVLFNINFAQLVTVLSMTDAIEYGQLKNGNRNEAVVLAVRPMLDKITGAFSNGIVGAIALVAGMTGSATAADMTASNIHTFELLAFYLPLACAILSLLVFTFKVTITEKKHAEIVEELQAKLATGEAADVAVTPASDILTTEILAPVSGQPLALADVKSAAQPQGLPGVGFAIRPSDGRLYAPFDGTIRFTFSTKHTLGIVSADGLETIIHVGIGTVNLRGAGFTTYYQDGQVVHAGDLLMTFDRDLIKQSGYDDVVVTFFTQPGRVTAHTEDWSTEVQHGQSAMKVTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG2</accession>
    <name>F9UUG2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ISP2_5</name>
        <name evidence="8" type="ordered locus">lp_3496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890978.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3496"/>
    <dbReference type="EnsemblBacteria" id="CCC80464">
        <property type="protein sequence ID" value="CCC80464"/>
        <property type="gene ID" value="lp_3496"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3496"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2912"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="OMA" id="QFVVICQ"/>
    <dbReference type="PhylomeDB" id="F9UUG2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2952-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="556" mass="65059" checksum="2A0D245C75F31A81" modified="2011-10-19" version="1">MQDYYNMNQTTLSIALDYQPEEHHSARYINQLVESLKLKYDYQFGRPREYNLGAMLKLVLLAYSYGIFSSRKIERFARENKPAGWLIADQIPSYRTICRFRISDELATLTTDSLSQLTQYLRQNGMIDDVSFIDGTKILADANKYSFVWKKNTIRFDKMNREKLVDLLGELHEAKIVGEIPAGSELTPELLDIMISKVEDHLVVLNETVEATKQVSPNPAKQQRRTVKSQKRKLDKRRDKMREHQAQQAIYDQRNSYSKTDHDATFMRVKEDPMQNGQLKPAYNVQIATSNQFITGYRLFQNPTDTRTLQPFIEHLKANNVLGHTIVADAGYGSESNYRYLEDEFGQHTVLIPYGTMLKENSRKWQSDDRKVMNWDYHEKDDYFINPQNVRFNFNAYRQRTDKYGFTRDFKEYIAEKYDENHQLISAALTPKGYLKRISVNENWEYFKSKQRELLSAPETGQIYAQRKIDVEPVFGKMKASLHFNRFSVRGFDKVTKEAGIVILALNIMKLVTVGTNFKNQRRKQMGRETKIRFLVPFAYTEASYVTASFRLIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUG3</accession>
    <name>F9UUG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shikimate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_3497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643564.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3497"/>
    <dbReference type="EnsemblBacteria" id="CCC80465">
        <property type="protein sequence ID" value="CCC80465"/>
        <property type="gene ID" value="lp_3497"/>
    </dbReference>
    <dbReference type="GeneID" id="57026710"/>
    <dbReference type="KEGG" id="lpl:lp_3497"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2913"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045105_0_2_9"/>
    <dbReference type="OMA" id="SRYYRVF"/>
    <dbReference type="PhylomeDB" id="F9UUG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2953-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="413" mass="43939" checksum="18545B09D85E3F3C" modified="2011-10-19" version="1">MTSNTNSNRKYYVTALALYFAYFILGIASSIMGQYKTEFAKAWGASTLANGTIDVSMVVSVIAAYGLGRLIAYPFAGPVSDRIGRRISGFIGIALYAVFFFGMITVHSMWWAYAIGIINGIANSFLDTCVSPSVMEIFPKSASIANLFTKFAITVAQFVLPFVIGLVASAQMSYRVIFIGCGILMIADAILVLVLPFPKQDKATAEAKTTTDKPKHRFTPAAIASILIGFTSSATFMIWLNCNQELGASYGIKDPSILQSFYAVGATVAVLLTAQFIHMGLKETTVLVLYPSISIVMLMLCYFINNPVILYIGSFVIGYAAAGGVLQLATSTTIGFFPDSKGLATSLVMIASSVANYAVLSAAAYLTKVTGADAPRMIILMNIVITLIGVGLALIVKHGGRSTRTSAASGVES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RX0</accession>
    <accession>F9ULM9</accession>
    <name>RNPA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component</fullName>
            <shortName evidence="1">RNase P protein</shortName>
            <shortName evidence="1">RNaseP protein</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnpA</name>
        <name type="ordered locus">lp_3688</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891150.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RX0"/>
    <dbReference type="SMR" id="Q88RX0"/>
    <dbReference type="STRING" id="220668.lp_3688"/>
    <dbReference type="EnsemblBacteria" id="CCC80636">
        <property type="protein sequence ID" value="CCC80636"/>
        <property type="gene ID" value="lp_3688"/>
    </dbReference>
    <dbReference type="GeneID" id="49395611"/>
    <dbReference type="GeneID" id="57026862"/>
    <dbReference type="GeneID" id="66448156"/>
    <dbReference type="KEGG" id="lpl:lp_3688"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3081"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_1_9"/>
    <dbReference type="OMA" id="PEQKHFR"/>
    <dbReference type="PhylomeDB" id="Q88RX0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3123-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000198475" description="Ribonuclease P protein component">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <sequence length="114" mass="13167" checksum="CAC71DCC820A359C" modified="2003-06-01" version="1">MRKSYRVKKETEFQQVFETRNSYANRQFVIYVLEKPGQPHFRVGISVGKKIGNAVARNWVKRRIRQSITELKPQLKQDADFLVIARPTVAGKSQAETKAYLSHALKLAHLLDND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SK6</accession>
    <accession>F9UU87</accession>
    <name>Y3408_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Macro domain-containing protein lp_3408</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_3408</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645538.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890903.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88SK6"/>
    <dbReference type="SMR" id="Q88SK6"/>
    <dbReference type="STRING" id="220668.lp_3408"/>
    <dbReference type="EnsemblBacteria" id="CCC80389">
        <property type="protein sequence ID" value="CCC80389"/>
        <property type="gene ID" value="lp_3408"/>
    </dbReference>
    <dbReference type="GeneID" id="57026635"/>
    <dbReference type="KEGG" id="lpl:lp_3408"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2838"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_9"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="PhylomeDB" id="Q88SK6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2876-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000089195" description="Macro domain-containing protein lp_3408">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00490"/>
        </source>
    </evidence>
    <sequence length="172" mass="17977" checksum="54CA28818AA8F3B6" modified="2003-06-01" version="1">MVEIKVIHGDITKMTVDAIVNAANTSLLGGGGVDGAIHRAAGPALLAACRPLHGCATGEAKITPGFRLPAKYVIHTPGPVWQGGQHNELQLLANSYRNSLNLAAENHCQTVAFPSISTGVYHFPLSIAAPLALKTLQATAQTTAHTVQTITIVCFDDQTQNVFSTALAALTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UH8</accession>
    <accession>F9UR37</accession>
    <name>Y2508_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0237 protein lp_2508</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2508</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0237 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CCC79676" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79676.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890190.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UH8"/>
    <dbReference type="SMR" id="Q88UH8"/>
    <dbReference type="STRING" id="220668.lp_2508"/>
    <dbReference type="EnsemblBacteria" id="CCC79676">
        <property type="protein sequence ID" value="CCC79676"/>
        <property type="gene ID" value="lp_2508"/>
    </dbReference>
    <dbReference type="GeneID" id="57025940"/>
    <dbReference type="GeneID" id="66450227"/>
    <dbReference type="KEGG" id="lpl:lp_2508"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2113"/>
    <dbReference type="eggNOG" id="COG3830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155669_2_0_9"/>
    <dbReference type="PhylomeDB" id="Q88UH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2168-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04872">
        <property type="entry name" value="ACT_1ZPV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01054">
        <property type="entry name" value="UPF0237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022986">
        <property type="entry name" value="UPF0237_ACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000219900" description="UPF0237 protein lp_2508">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="89" mass="9786" checksum="90E96CCA28EF0837" modified="2004-07-19" version="2">MKAIITVVGQDQVGIVAKVANELARLKINIVDISQTLMDHNFTMMLSAEWDDQQLSFAAAKAALESLGEASELTIRIQRQAVFDAIQKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UT8</accession>
    <accession>F9UQR8</accession>
    <name>ATPL_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit c</fullName>
            <shortName evidence="1">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">lp_2369</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639224.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890071.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UT8"/>
    <dbReference type="SMR" id="Q88UT8"/>
    <dbReference type="STRING" id="220668.lp_2369"/>
    <dbReference type="EnsemblBacteria" id="CCC79557">
        <property type="protein sequence ID" value="CCC79557"/>
        <property type="gene ID" value="lp_2369"/>
    </dbReference>
    <dbReference type="GeneID" id="57025901"/>
    <dbReference type="GeneID" id="66450114"/>
    <dbReference type="KEGG" id="lpl:lp_2369"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2002"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_1_1_9"/>
    <dbReference type="OMA" id="QPELMNE"/>
    <dbReference type="PhylomeDB" id="Q88UT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2041-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000184407" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="70" mass="7168" checksum="C83D8A9C8866ECF8" modified="2003-06-01" version="1">MGAIAAGIAMFGAALGAGIGNGLVISKMLEGMARQPELSGQLRTNMFIGVGLIESMPIISFVVALMVMNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UX7</accession>
    <accession>F9UQM9</accession>
    <name>SYV_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">lp_2322</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101712.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890032.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UX7"/>
    <dbReference type="SMR" id="Q88UX7"/>
    <dbReference type="STRING" id="220668.lp_2322"/>
    <dbReference type="PRIDE" id="Q88UX7"/>
    <dbReference type="EnsemblBacteria" id="CCC79518">
        <property type="protein sequence ID" value="CCC79518"/>
        <property type="gene ID" value="lp_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2322"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1963"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_9"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="PhylomeDB" id="Q88UX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2002-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224491" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="816"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="532"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="889" mass="101526" checksum="9D875D34447942EA" modified="2003-06-01" version="1">MSEEPTTDMPTKYDPTAVEAGRYQTWLDQDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEAKLREQGISRYDLGREKFIQQVWDWKDEYASIIKQQWAKMGLSLDYSRERFTMDDGLSDAVKKVFVDLYNKGLIYRGEYIINWDPQARTALSDIEVIHKDDKGAFYHVKYPFADKDYTFNGKHYIEIATTRPETMMGDTAVAVNPSDDRYKELVGKKVILPLAEREIPIIADAYVDPEFGTGMVKITPAHDPNDFKVGNRHDLKRINTMNDDASMNANAGKYEGMDRFEARKAMVKDLEDQDLMIKIDPIVHSVGHSERTDVQVEARLSTQWFVKMKPLAEQALKNQEGDDAVDFIPKRFEDAFKQWMENIHDWVISRQLWWGHRIPAWYNKTTGETYVGVDGPKDPENWEQDPDVLDTWFSSALWPFSTMGWPNTDAEDFKRYFPTNTLVTGYDILPFWVSRMIFQSLEFTGRRPFKNVLLHGLIRDEHGVKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSTAGQDVRFSYTKMDAAWNFINKIWNASRYVIMNLGTMDKPELPAASDWTLADKWILSRLNATVKQVTTTFDKFDFGEAGRALYNFIWNDFCDWYIEMSKEVLTGDDAQAKANTQNVLAYVLDQILRLLHPIMPFVTEKIWLSMPHVGESLVVAAYPVDHPEFDDETAESDMASLIELITAVRSIRAEANAKMSSAVDLLIKTDNTRLQAVFKANEDYIQRFAHPKTLSIGADVVAPKLAMTQVISDAEVYIPLAELVDLDEEVKKLEKEQAKFESEVARATKKLGNERFVANAPEDVVNSEKEKLADNQTKLAALKQRLVDIKAEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WG8</accession>
    <accession>F9UP35</accession>
    <name>FABH2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2</fullName>
            <ecNumber evidence="1">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase III protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketoacyl-ACP synthase III 2</fullName>
            <shortName evidence="1">KAS III 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabH2</name>
        <name type="ordered locus">lp_1671</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101499.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889488.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WG8"/>
    <dbReference type="SMR" id="Q88WG8"/>
    <dbReference type="STRING" id="220668.lp_1671"/>
    <dbReference type="EnsemblBacteria" id="CCC78974">
        <property type="protein sequence ID" value="CCC78974"/>
        <property type="gene ID" value="lp_1671"/>
    </dbReference>
    <dbReference type="GeneID" id="66449542"/>
    <dbReference type="KEGG" id="lpl:lp_1671"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1410"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_1_9"/>
    <dbReference type="OMA" id="QFVFKNA"/>
    <dbReference type="PhylomeDB" id="Q88WG8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1437-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110438" description="3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="1">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <sequence length="328" mass="35279" checksum="971587F292A3D6D8" modified="2003-06-01" version="1">MTTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVAQQLLQQSRLAATAIDLIIVATMSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGMQLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGAGGLLITAKPNTTTGHWLGGHYATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALMQARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVAQKQVQRGDKLVFTGFGGGLSVGSAVIEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WR2</accession>
    <accession>F9UNT9</accession>
    <name>SYFB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">lp_1559</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101464.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889392.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WR2"/>
    <dbReference type="SMR" id="Q88WR2"/>
    <dbReference type="STRING" id="220668.lp_1559"/>
    <dbReference type="EnsemblBacteria" id="CCC78878">
        <property type="protein sequence ID" value="CCC78878"/>
        <property type="gene ID" value="lp_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1559"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1312"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_9"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="PhylomeDB" id="Q88WR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1339-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126899" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="712"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <sequence length="805" mass="88119" checksum="53D0A7DDE854B8BD" modified="2003-06-01" version="1">MRISTTWLRDYLKLDIPADELAEKIERTAVEVDGVIRPSEGLKKVVVGHVLTCEPHPDSDHLHVCQVDVGESEPLQIVCGAPNVAAGEKVIVALPNSWIGGHTKIKKSKMRGVPSNGMLCALDELGFDEKLVPKEVADGIFILPDDATPGDPVFSYLGMDDEIIDMSVTPNRGDMLSMNGTAHELAAIYDQQPTMPKVDLYEDATTVAADDLHVAVAADEHDVPMYKMRLIKNVTIKPSPLWLQIRIWNAGMRPINNVVDATNYILMQYGQPLHAFDFDQLNDGQINVRLAKAGEHLTTLDGEDRELLTSDLLICSGDQPICLAGTMGGLATEVTDQTTTIALEGAVFDAVKIRKTAHNHDLHSEASMRYERGIDHGMTATALDAAAAMIAELGDGQVASGMVIGRDEDVQPTTVTIDLARINHVLGTELSLDTVSDIFKRLDFPTVVANETFTVTVPSRRWDIHIPADLIEEIARLYGYDNLPATLPTGQPTIGKLNETQQVIRDSRKLMESAGLTQAISYSLTTETKSKAFALHASDVTKLDFPMSSERTTLRLSLVSGLLDDLAYNNARKEHNVALYEEGRVFYSQPEQVRPKEIEHIAGAITGSMVPKSWGVAEQPVDFFQIKGIVAGYLKSLALQDAVSYVATAEHPEMHPGRTADIYVGDQLVGFVGEVHPTTAKAYKIRETYVFELDLTALIALPKARQQYQPISKFPSITRDVAMLIDDDVTNATVVALINKKGGAHLRHVQLFDVYNGSHVPAGKKSLAYTLTYQDQNATLVDDDVTTAFEKVLTALTDELGAEIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XP4</accession>
    <accession>F9UMV2</accession>
    <name>Y1151_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized RNA methyltransferase lp_1151</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1151</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XP4"/>
    <dbReference type="SMR" id="Q88XP4"/>
    <dbReference type="STRING" id="220668.lp_1151"/>
    <dbReference type="EnsemblBacteria" id="CCC78541">
        <property type="protein sequence ID" value="CCC78541"/>
        <property type="gene ID" value="lp_1151"/>
    </dbReference>
    <dbReference type="GeneID" id="66449040"/>
    <dbReference type="KEGG" id="lpl:lp_1151"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.972"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_9"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="PhylomeDB" id="Q88XP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-983-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000161989" description="Uncharacterized RNA methyltransferase lp_1151">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <sequence length="457" mass="51003" checksum="B5EDC8A80F7ED2F8" modified="2003-06-01" version="1">MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFGDVEKINQVSPHRVNPKGRVYRQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLPTIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPIEDYYIQDPAIDKAIVVVRDILRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEVVSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLAIDQAGLTGNETVIDAYSGIGTISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATFVLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAGEMAPKRVVYISCNPSTLVRDVQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-27" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XW2</accession>
    <accession>F9UMM9</accession>
    <name>RS13_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">lp_1060</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641265.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888982.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XW2"/>
    <dbReference type="SMR" id="Q88XW2"/>
    <dbReference type="STRING" id="220668.lp_1060"/>
    <dbReference type="EnsemblBacteria" id="CCC78468">
        <property type="protein sequence ID" value="CCC78468"/>
        <property type="gene ID" value="lp_1060"/>
    </dbReference>
    <dbReference type="GeneID" id="57024715"/>
    <dbReference type="GeneID" id="66448971"/>
    <dbReference type="KEGG" id="lpl:lp_1060"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.895"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_1_9"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="PhylomeDB" id="Q88XW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-911-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132100" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="121" mass="13638" checksum="59A3936F012D46B4" modified="2003-06-01" version="1">MARIEGIDLPRDKRIVIGLTYIYGIGNTSAQKILAEAGVSEDVRVRDLTPDQEDKIRAVVDGYKTEGDLRREVSLNIKLLQEIGSYRGMRHRRGLPVRGQHTKNNARTRKGKKVSIAGRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX7</accession>
    <accession>F9UML4</accession>
    <name>RS17_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">lp_1044</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888967.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX7"/>
    <dbReference type="SMR" id="Q88XX7"/>
    <dbReference type="STRING" id="220668.lp_1044"/>
    <dbReference type="EnsemblBacteria" id="CCC78453">
        <property type="protein sequence ID" value="CCC78453"/>
        <property type="gene ID" value="lp_1044"/>
    </dbReference>
    <dbReference type="GeneID" id="57024700"/>
    <dbReference type="GeneID" id="66448956"/>
    <dbReference type="KEGG" id="lpl:lp_1044"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.880"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_9"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="PhylomeDB" id="Q88XX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-896-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000233492" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="89" mass="10347" checksum="98360E2A90449EE0" modified="2003-06-01" version="1">MSEDTRNSRKVIQGRVVSDKMDKTIVVIVETYKNHPVYGKRVRYSKKFKAHDEKNEAKTGDIVKIMETRPLSATKRFRLIEVVQKAVII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y74</accession>
    <accession>F9UMB5</accession>
    <name>GUAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaA</name>
        <name type="ordered locus">lp_0914</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644035.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888868.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y74"/>
    <dbReference type="SMR" id="Q88Y74"/>
    <dbReference type="STRING" id="220668.lp_0914"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="CCC78354">
        <property type="protein sequence ID" value="CCC78354"/>
        <property type="gene ID" value="lp_0914"/>
    </dbReference>
    <dbReference type="GeneID" id="57024595"/>
    <dbReference type="KEGG" id="lpl:lp_0914"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.774"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_9"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="PhylomeDB" id="Q88Y74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-790-MON"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140138" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <sequence length="518" mass="57457" checksum="23069C31A04EBC36" modified="2003-06-01" version="1">MAKTDTASFDSILVLDFGSQYNQLITRRIRDFGVYSELLPNTITAEEIKARHPKGIIFSGGPNSVYDDGAFRVDPEIFKLGLPILGICYGMQLMTYTLAGGKVESADNREYGKANIDVTSDSATLFKDTPAEQSVWMSHGDLVTQAPDGFDVVATSKNCPIAAIQDVDRKLYGIQFHAEVRNTDYGNDILRHFAFDVCQAEANWSMDDFIDMQIEKIRAEVGDKKVLLGLSGGVDSSVVGVLLHKAIGTQLTSIFVDHGLLRKGEADQVMASLEGKFGLNIIKVDAKDRFLSKLAGVSDPERKRKIIGNEFIQVFDEEATKLNGMEFLAQGTLYTDVIESGTSTAQTIKSHHNVGGLPEDMQFKLIEPLRTLFKDEARELGEKLGMPSDLVWRQPFPGPGLGIRVIGEITEDKLEIVRDSDFILRDEIKKAGLDREIWQYFTVLPGIKSVGVMGDGRTYDYTVGIRAVTSIDGMTADFARIPWDVLQKISVRIVNEVDHVNRIVYDVTSKPPSTIEWE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YP3</accession>
    <accession>F9ULU1</accession>
    <name>YABA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Initiation-control protein YabA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_0706</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in initiation control of chromosome replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with both DnaA and DnaN, acting as a bridge between these two proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YabA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640967.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888694.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YP3"/>
    <dbReference type="SMR" id="Q88YP3"/>
    <dbReference type="STRING" id="220668.lp_0706"/>
    <dbReference type="DNASU" id="1062799"/>
    <dbReference type="EnsemblBacteria" id="CCC78180">
        <property type="protein sequence ID" value="CCC78180"/>
        <property type="gene ID" value="lp_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="57024415"/>
    <dbReference type="GeneID" id="66448684"/>
    <dbReference type="KEGG" id="lpl:lp_0706"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.593"/>
    <dbReference type="eggNOG" id="COG4467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157169_0_0_9"/>
    <dbReference type="OMA" id="TEGDCLF"/>
    <dbReference type="PhylomeDB" id="Q88YP3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-615-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01159">
        <property type="entry name" value="YabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010377">
        <property type="entry name" value="YabA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06156">
        <property type="entry name" value="YabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021439">
        <property type="entry name" value="DUF972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211910" description="Initiation-control protein YabA">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01159"/>
        </source>
    </evidence>
    <sequence length="115" mass="13614" checksum="1B6C04AABC7AF76B" modified="2003-06-01" version="1">MDKRDLYDSFGEMEQQMQQMLDKMAKLRADMTTVLEKNAELVIENEHLREHMVEIENELPKKAASTTTLSKSRQNLEKLYDEGFHVCNQFYGKRRDDDESCVFCLEVIYGERERA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YZ2</accession>
    <accession>F9UL61</accession>
    <name>ACCD1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1</fullName>
            <shortName evidence="1">ACCase subunit beta 1</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta 1</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD1</name>
        <name type="ordered locus">lp_0591</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101069.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YZ2"/>
    <dbReference type="SMR" id="Q88YZ2"/>
    <dbReference type="STRING" id="220668.lp_0591"/>
    <dbReference type="EnsemblBacteria" id="CCC78076">
        <property type="protein sequence ID" value="CCC78076"/>
        <property type="gene ID" value="lp_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0591"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.495"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_1_9"/>
    <dbReference type="OMA" id="MSHYPAS"/>
    <dbReference type="PhylomeDB" id="Q88YZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-507-MON"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000389768" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01136"/>
        </source>
    </evidence>
    <sequence length="267" mass="29232" checksum="D40A158E432C3211" modified="2003-06-01" version="1">MSHYPASGTWQACPKCGRHVHQRQWGTYQQCPYCHYWQRLTTAQRLEQLVDEGSFQPLTMTERPVNQLGFPDYMNKLRRAQRQTGLNEAVVCGTALIEQQPCILAVMDSHFMMGTLNTAVTRRLLHASEQARAQRLPLIIVTASGGARMQEGVYALVGMNLILAELARLAATPLPLITVLTDPTMGGVSASFAFKGDLIIAEAGAKIGFAGARVIQQTLPVKLPADFQTADQLFKNGMVDAVVERPQLRSTLGQALVNYGIGRSAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZC1</accession>
    <name>Q88ZC1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein PlnT,membrane-bound protease CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plnT</name>
        <name evidence="3" type="ordered locus">lp_0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0425"/>
    <dbReference type="EnsemblBacteria" id="CCC77932">
        <property type="protein sequence ID" value="CCC77932"/>
        <property type="gene ID" value="lp_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0425"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079560_5_2_9"/>
    <dbReference type="OMA" id="ANWEPWI"/>
    <dbReference type="PhylomeDB" id="Q88ZC1"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="181" mass="20213" checksum="B8A0EDD8B8703A02" modified="2003-06-01" version="1">MPWKLGGYIGFIGIQHELGNYQVATLKSRVNIAQLGTVIIAMLTMVVLIIVDLKLGAMLNIPETSNSRSLAWMLGEAPLPMIVSVVIFSPICEELIFRGIFFSYALTNQYNHRNYQMIAVVINSLIFASVHVDANWEPWIYYTLMGSILGTTYLLAKRDIRMNILVHMGTNLAVFALAAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX5</accession>
    <name>F9UKX5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101032.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0493"/>
    <dbReference type="EnsemblBacteria" id="CCC77990">
        <property type="protein sequence ID" value="CCC77990"/>
        <property type="gene ID" value="lp_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0493"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.407"/>
    <dbReference type="eggNOG" id="COG0027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_2_9"/>
    <dbReference type="OMA" id="GYMSGWT"/>
    <dbReference type="PhylomeDB" id="F9UKX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-411-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="114"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="413" mass="46211" checksum="74B006326366FA4C" modified="2011-10-19" version="1">MKKRVILIEPSFYGVSFVRAARELGCEVICVVSDQKDPQKFGYEGEYDQLLIADIRDSDSVLKAIQNSKYKRFDAIIPATDYATAVTAKVAEKLNMFGNSYFATKCARNKDLARIQYAKKGVPSAKFAVAKTIDEALEASKKIGFPLILKPTNTASSIDVFYVSDEQQLRERFLQISQLKQSYMHFKVREEYILEEFMSGPEFSVELFLSNNEIAFVEVTEKHTTKPPYFVELMHVFPTTVDVAYKKEIINTAYCAVRALGFHNGPTHAEVKLTDAGARVVEVNGRPGGDNITSDLIKDAYGIDIFKKTVELYLNKTVTIKPTRHGAAAISFLFANSKGSFESVQGLDNIKTTQGFRRLEMEVSPGDKVVPPTNSDDRIGYYILSGSNANKLKETIEDLNLKVHVIVKSDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL16</accession>
    <name>F9UL16_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">divIC</name>
        <name evidence="3" type="ordered locus">lp_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888545.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0542"/>
    <dbReference type="EnsemblBacteria" id="CCC78031">
        <property type="protein sequence ID" value="CCC78031"/>
        <property type="gene ID" value="lp_0542"/>
    </dbReference>
    <dbReference type="GeneID" id="57024317"/>
    <dbReference type="GeneID" id="66448593"/>
    <dbReference type="KEGG" id="lpl:lp_0542"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.449"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134863_2_0_9"/>
    <dbReference type="OMA" id="NVHERND"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-452-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039076">
        <property type="entry name" value="DivIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40027">
        <property type="entry name" value="PTHR40027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="132" mass="15238" checksum="F8B1725809D0644B" modified="2011-10-19" version="1">MTNGSRNKIKQLDNDYIRQVATDEHGQAQRVAQVRRRRFILIVAVFGALILFFGFQLINTRSNLHQVNRQVATSQVKLKKVQQKNNQLESQIKQLNNKDYLQKLLRSKYDYTKSGETVYSLPNDNAADVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL44</accession>
    <name>F9UL44_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888573.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UL44"/>
    <dbReference type="STRING" id="220668.lp_0574"/>
    <dbReference type="EnsemblBacteria" id="CCC78059">
        <property type="protein sequence ID" value="CCC78059"/>
        <property type="gene ID" value="lp_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0574"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.477"/>
    <dbReference type="eggNOG" id="COG4990">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067297_2_1_9"/>
    <dbReference type="OMA" id="CEMTATT"/>
    <dbReference type="PhylomeDB" id="F9UL44"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-490-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02549">
        <property type="entry name" value="Peptidase_C39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039563">
        <property type="entry name" value="Peptidase_C39_single_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394244" evidence="1">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="284" mass="32043" checksum="B5F12FBFA644B0F0" modified="2011-10-19" version="1">MIRMSRWWWRILVGGLLVSGVVYPAQAAVTTYPITGIQVVQPRVYQTNSQNGVGYHLTVVRHQRAQLRVNLHLKYHQHTQWTRTEQADIYRNGHYQRFYYVHNGHQQSGWIAANQLKPASTASVQLRVPLIDQLPELPTGCEMTATTMMLQYAGVNINKEQFASHVPRSSNPNTGFVGDPASAYGIGLYIYPQGLLPTIRHYLPSAVDLSGVGLQRIKVQLAKRHPVVAWVQGLDGFASHTVTLTGYTAATIRYNDPWRGQSGQMDNQAFETMWQLNGRRALSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL92</accession>
    <name>F9UL92_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888621.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0629"/>
    <dbReference type="EnsemblBacteria" id="CCC78107">
        <property type="protein sequence ID" value="CCC78107"/>
        <property type="gene ID" value="lp_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0629"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.527"/>
    <dbReference type="eggNOG" id="ENOG50333JH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1936936_0_0_9"/>
    <dbReference type="OMA" id="LGWIGRI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-540-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="12237" checksum="FA905914B39C78B8" modified="2011-10-19" version="1">MKTKNLALTNGIVGLVGGIILLFGGWFVAGGALSDAATGSATSTSGTVALLNILKIAILALGIIALIYYKGDSRVNTAPGVLLIVGGAIALIPFLGWIGGIIAIIGGSLYLAALKNFSQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULA5</accession>
    <name>F9ULA5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, galactitol-specific EIIA component</fullName>
            <ecNumber evidence="2">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pts35A</name>
        <name evidence="2" type="ordered locus">lp_3548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.69" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642910.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891026.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3548"/>
    <dbReference type="EnsemblBacteria" id="CCC80512">
        <property type="protein sequence ID" value="CCC80512"/>
        <property type="gene ID" value="lp_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3548"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2959"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_6_0_9"/>
    <dbReference type="OMA" id="HAQLEML"/>
    <dbReference type="PhylomeDB" id="F9ULA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3000-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="156" mass="17550" checksum="12330EB3B7FDB15B" modified="2011-10-19" version="1">MSENLVEVSDYLRDQLIFLHTSFKTSKELFTAINAKAQENGFVTDQFLPKIIKRESTFPTGLQLEHRGVAIPHTDADTINKEFVAVVVNDAPIAFSRMDDPEQKVDAKLVFVLGLNKPHAQLEMLQALMGIIQDDSLVNSLENAENFNQIHQLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULL1</accession>
    <name>F9ULL1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator of phenolic acid metabolism, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">padR</name>
        <name evidence="3" type="ordered locus">lp_3664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641608.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891132.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3664"/>
    <dbReference type="EnsemblBacteria" id="CCC80618">
        <property type="protein sequence ID" value="CCC80618"/>
        <property type="gene ID" value="lp_3664"/>
    </dbReference>
    <dbReference type="GeneID" id="57026844"/>
    <dbReference type="GeneID" id="66448142"/>
    <dbReference type="KEGG" id="lpl:lp_3664"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3062"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_1_3_9"/>
    <dbReference type="OMA" id="QFGHYLV"/>
    <dbReference type="PhylomeDB" id="F9ULL1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3105-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="97"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="181" mass="21080" checksum="FD072634A06A1B43" modified="2011-12-14" version="1">MAQKNKLQFIILGLLNQQPLTGYDLTKAFDDEIGEFWQAQHSQIYPQLKRLEEQGYVTHEITVSGEKLEKKLYHITATGRQLLHEWISVGTPDLTATKDEFILKLYFIQTDRDPRLLAMLQEQLTLHTAKLAHLQQRLATVFPQAKAAKQHYGHYLILQHAIGREDYYVNWLKQTLKALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULN6</accession>
    <name>F9ULN6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 24, holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888639.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0647"/>
    <dbReference type="EnsemblBacteria" id="CCC78125">
        <property type="protein sequence ID" value="CCC78125"/>
        <property type="gene ID" value="lp_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0647"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.541"/>
    <dbReference type="eggNOG" id="COG4570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124338_1_0_9"/>
    <dbReference type="OMA" id="KIIMRVE"/>
    <dbReference type="PhylomeDB" id="F9ULN6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-558-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="16188" checksum="8FE7C460280047C9" modified="2011-10-19" version="1">MIKHTFMLTPVQQQRPRATHYGRSIRLYDPKAVKQFKQAIAEEAMLTYRHQPLSGSLAVALVFYRPVQQSLSKVEKQRRIDGKHLPVVKPDLDNYIKSFLDALHSIYWQDDALITDIVASKRYGRQPRIEIEVKEIEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM47</accession>
    <name>F9UM47_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitroreductase family protein</fullName>
            <ecNumber evidence="5">1.19.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EC" id="1.19.6.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101171.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888800.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0829"/>
    <dbReference type="EnsemblBacteria" id="CCC78286">
        <property type="protein sequence ID" value="CCC78286"/>
        <property type="gene ID" value="lp_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0829"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.704"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_0_2_9"/>
    <dbReference type="OMA" id="NDHPLEM"/>
    <dbReference type="PhylomeDB" id="F9UM47"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-722-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="PTHR43425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="27707" checksum="10B884C90925A74C" modified="2011-10-19" version="1">MTKSVSETLQDHRTRRQFTTEPISDAQFAQIITTAQQMPTSQYLQAYSLIEITQPALRQQLATITMMPTVGENGRLLVVVADQHRNVKLAPGATTRRALSEFDRFAGSIEDATLITAAMVMVAESMGLGSVVLGSINNDTQAVIDALHLPDLTLPVFGLQLGHPADVPEKKPRLGLPAVLFQDTYAEPASYQAELDRFDGVLNQYYQHRSSHARTEHLAHMTQEATHSAAKRREFLTIARQQGFLPELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM59</accession>
    <name>F9UM59_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipooligosaccharide cholinephosphotransferase</fullName>
            <ecNumber evidence="1">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">licD</name>
        <name evidence="1" type="ordered locus">lp_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="AL935263">
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    <dbReference type="RefSeq" id="YP_004888812.1">
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    <dbReference type="STRING" id="220668.lp_0844"/>
    <dbReference type="DNASU" id="1062619"/>
    <dbReference type="EnsemblBacteria" id="CCC78298">
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        <property type="gene ID" value="lp_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="57024540"/>
    <dbReference type="KEGG" id="lpl:lp_0844"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.718"/>
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        <property type="entry name" value="LicD_fam"/>
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        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    <sequence length="269" mass="31735" checksum="9E001207373CF2FE" modified="2011-10-19" version="1">MPLTPLHQVELRLMRTVIAICEAENIDYFLIGGSLLGAIRHHGFIPWDDDIDIGMRRHDYQRFIAVANHHLDPNKFFLQTGASDPDYALSYMKLLDVNTYIEERNNVNNAFKGVFVDIFPFDKIPDDEALRRSQMLHYKLADAAILLKLNYRFVKTPLRNLITKHTPQQLAEVNRYKLEREEYMRLYEQSDSRTYKNLASQYDYEKEIMTYQELTELTTVPFEDIQVKIPSAYDTILTRMYGDYMQLPPADKRVEKHLNKLIIDNHEIL</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641122.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888836.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78322">
        <property type="protein sequence ID" value="CCC78322"/>
        <property type="gene ID" value="lp_0875"/>
    </dbReference>
    <dbReference type="GeneID" id="57024563"/>
    <dbReference type="GeneID" id="66448826"/>
    <dbReference type="KEGG" id="lpl:lp_0875"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.742"/>
    <dbReference type="eggNOG" id="ENOG502ZMQP">
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    <dbReference type="HOGENOM" id="CLU_180705_0_0_9"/>
    <dbReference type="OMA" id="TIQTNQK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-758-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9518" checksum="538D2EE18579B346" modified="2011-10-19" version="1">MLLDQAANMTNIIAAQIIKVFYPFVIAKTETGAYLKLNLSTNEQRDPLFWDELRSILQAKLWVPIGKHYHQLLDNGWLAESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMA8</accession>
    <name>F9UMA8_LACPL</name>
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        <submittedName>
            <fullName evidence="16">PTS system, beta-glucosides-specific EIIBCA component</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts12BCA</name>
        <name evidence="16" type="ordered locus">lp_0905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888861.1">
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    <dbReference type="STRING" id="220668.lp_0905"/>
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    <dbReference type="KEGG" id="lpl:lp_0905"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.767"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_3_9"/>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-783-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0103111">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIABC_b_glu"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTS-II-ABC-beta"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0418">Kinase</keyword>
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    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="103"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="489"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="620" mass="66867" checksum="6A8E9B6D138E4162" modified="2011-10-19" version="1">MTYKEMNDQIINGVGGKSNIESVVHCATRLRFVLKDEAKADDDLVRSIPGILQVVKKAGQYQLVIGNNVEDVYNELSDMLQLDENVDHNQSKDKRSIFDKIISTITGSIAPAIPLLAGAGMGKVLLLILTLSGLLTEKSQTYQMLNLIFDTGYFFMPAFIGFSAAKIFKTNQFLGAFMGLVTVNPNWVAMVAAGKPVSFIGVPIQLVSYSSTLITAILSVWLMSYIEKFVKKITPGMIKVFAEPMLIMLITAPLTFIVLGPIANLISMGIASISMFLYDNAGFIAIPLLAAAYPWLVSIGIHKALSPISIQLVATQGFDPIIRVVALCSNMSQAAASLAVGLKTKNKQLRALALSSTVTAYLGGITEPAMFGVNLKLKKPMYGAMIGGAVAGLFAGFMKMKAFIYVTPGLLSLPMWVSKTENYVVLAVATIVIASVATFIATWLIGFEDPVSEEVMKQKQAQANKVVTTKHSINSPVVGEARMLNEVNDETFASGVMGKGIAVIPTEGVVIAPTDGVASAVFDTSHAIGLHLDNDADLLIHVGIDTVELKGQYFETLVKKGERFHAGQELLRFDLDKIKQAGYDPTVMIIVLNTKDFLEVLPVPESNESVTADNNLLMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMC5</accession>
    <name>F9UMC5_LACPL</name>
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        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_0926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641172.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0926"/>
    <dbReference type="EnsemblBacteria" id="CCC78364">
        <property type="protein sequence ID" value="CCC78364"/>
        <property type="gene ID" value="lp_0926"/>
    </dbReference>
    <dbReference type="GeneID" id="57024605"/>
    <dbReference type="GeneID" id="66448864"/>
    <dbReference type="KEGG" id="lpl:lp_0926"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.784"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_4_0_9"/>
    <dbReference type="OMA" id="MRGNNNH"/>
    <dbReference type="PhylomeDB" id="F9UMC5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-800-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
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        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="84" mass="8535" checksum="36FF65F2D459A134" modified="2011-10-19" version="1">MLGWLWSLIVGGVIGALAGAITSRDVPMGIIGNIIAGLVGAWIGQALLGTWGPSLAGMALVPSILGAIILVLIVSAIFGMRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME2</accession>
    <name>F9UME2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mucus-binding protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_0946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888895.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0946"/>
    <dbReference type="EnsemblBacteria" id="CCC78381">
        <property type="protein sequence ID" value="CCC78381"/>
        <property type="gene ID" value="lp_0946"/>
    </dbReference>
    <dbReference type="GeneID" id="57024622"/>
    <dbReference type="KEGG" id="lpl:lp_0946"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.803"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272001_0_0_9"/>
    <dbReference type="OMA" id="YTFKAVQ"/>
    <dbReference type="PhylomeDB" id="F9UME2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-817-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388836" evidence="5">
        <location>
            <begin position="39"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="513"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="586"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="726"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="796"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="866"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="935"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="1189" mass="128181" checksum="841B4F21A8B9FF69" modified="2011-10-19" version="1">MKPNNVNNQNKRHQSRWVITSATAMILTTLTIASQAAAADDTVTTTTNEPTNSQLNTNTQVNATQVNLKADTSTSVSTIKSDQSAVAATSPTTSTGSPSEHSSSVNTNPQQQSANPASQSQATTTSESTPTTDIKHPTQTAPAQTTSASTTEPTTESNTESATDSQAKATTTDNQASKQPSQQAVPASSNSTTTEVNTQSATSSASTDDKIVTNVNQEKLVLKTNQPVVRAISRTASENINDWMPNTLLQQEVLSQLRKQNPDRTWNSAADITKADMLLLTTYYGKDTYIDGKTSYSLEGLQYATNLTTVWLNNNLNAPSGSYYSDVTDISPLANLQKLQVVNIQQNRITDISPLANLKNLTEVDAAYNHISDFSPLKGFKNLKGTFSNQFITLPPAYISADNNIATLAIDCYLPDGSKVQLKPNNGVGETVFYKNGQLYVRWYFNGAGGGNYDSNGHIYYTNMKPQQPGLTGPTFNGTTVIPMDDYYFMTAASDGNNFVVVRPYVLAATAAPITVKYVDALTGESLVTADLTLNGIVGQPYTTQRIDDELPNYDFTNIVGNASGVFTADAQTVTYYYTRKDAGDITIHMVDTNGNLVYEPQILPGKHNLGNAYNLDAPTFDHFKLHQTIGNAAGVFTTDPQSITFVYVRLDAGNITVKYQDKQGHQLKPDKTVSGSQSLGQTYTTEPLGIENYTLMTTPANATGTFTDQEQTVIYVYVRRDAGQIVVKYQDSAGNPLAPDKLLDGKEQLGVAYQTAAISIPNFYLVATPANATGTFSTDTQTVIYQYARSNAGHITVKYQDANGTTLAPDDVLTGDGQLGRPYQTSAKTIENYRLIQTPANATGQFSDQAQTVIYVYTREDAGDITVQYLDENGQQLAADSVLSGQGQLGQPYETSPLNINGYTVKSTQGNTTGTYTVQPQRVVYIYERTAGQPVTAKYQDQDGKSIHPDVVHSGYLGDNYSTEQLVIDGYTFKAVQGDVSGTFGTSAKTVTYVYTESTPTIPDTQGTVTVHYVTKDGIKLNEPTVLSGKTGTTYQTVPLTFTDHELVGQPENATGLFTADNVDVTYVYQATDTTGTDDIIDPEEPEQPTKPIKPTTPETPNEPGTTVTQPDRIKPTQPAVAVKPAATVKPTLKPAAAQASLVKTTSPVTEHSAQLPQTDEQTGKLAVILGLLLSVVTLGFYGKNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ1</accession>
    <name>F9UMJ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysP</name>
        <name evidence="8" type="ordered locus">lp_1008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641236.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888944.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1008"/>
    <dbReference type="EnsemblBacteria" id="CCC78430">
        <property type="protein sequence ID" value="CCC78430"/>
        <property type="gene ID" value="lp_1008"/>
    </dbReference>
    <dbReference type="GeneID" id="57024670"/>
    <dbReference type="KEGG" id="lpl:lp_1008"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.854"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_9"/>
    <dbReference type="OMA" id="AMFSTAN"/>
    <dbReference type="PhylomeDB" id="F9UMJ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-866-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="483" mass="52704" checksum="9775627DFFAD2914" modified="2011-10-19" version="1">MAEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYFLMTSLGEMATYLPVSGSFSTYATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFWLPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKVVTVLVFLVIGVLTIVGIMGGHATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQVFWRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVILTSVLSAANSGMYASTRMLYSLSLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLFGERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQLSELRYHAKWFPFGPWFAFILCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRHHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS5</accession>
    <name>F9UMS5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malolactic regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mleR1</name>
        <name evidence="3" type="ordered locus">lp_1116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889028.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1116"/>
    <dbReference type="DNASU" id="1063294"/>
    <dbReference type="EnsemblBacteria" id="CCC78514">
        <property type="protein sequence ID" value="CCC78514"/>
        <property type="gene ID" value="lp_1116"/>
    </dbReference>
    <dbReference type="GeneID" id="57024762"/>
    <dbReference type="KEGG" id="lpl:lp_1116"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.944"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="EPYIMLT"/>
    <dbReference type="PhylomeDB" id="F9UMS5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-957-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="300" mass="34330" checksum="43812DCF61538C1E" modified="2011-10-19" version="1">MNTKDLAYFDELISQKNFSKVAKTFGVSQPTVTTAIKRLESEFGAPLVIRDRVKNTLHVTASGAQLAEHAKIVLHELRLAHQEIDNLSQNRLILGLPPIIENHYFPKIGARLAAEGLLAGLETIEGGSIWLRNAVRDGRVDMTLLGSVEPLAYQTLIAEEFDRQPFCIYVSKQHPLAQRKRVYFNELRREKFVFFNSNFIHNTAFNKLTRRNHFRPNIVFRSNDTHVLMKLIGENVGIGFFTKIVDHYRTDVVRLDLMDIEPPEFITSIVYRTTHILTPVQQQLLTILHETLAVDTDQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV5</accession>
    <name>F9UMV5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts13C</name>
        <name evidence="11" type="ordered locus">lp_1155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101271.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889058.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1155"/>
    <dbReference type="EnsemblBacteria" id="CCC78544">
        <property type="protein sequence ID" value="CCC78544"/>
        <property type="gene ID" value="lp_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1155"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.975"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_5_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMV5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-986-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="438" mass="48057" checksum="1FF564EE9816BA65" modified="2011-10-19" version="1">MWLDEQRLIQRLVPRLLRFRQTNFYRIIQRTLMLTFPFILIGTFSQIIQLTVLTKKGFIASIFHLSKWVPYYRYLHYPFDSLTTLTLNGVAVVAAFGAAKYHAKLNQRDDQLAGLTAAIALLIVAYQYTNQNQIGVFNTLLIGTNGLTGALIVGGLTGLLFKWFSKPVPAQSSPHTADILTRTFSSLLPMALILVLAVLVSLALNWLMIITYSAESWSAFQKYATTSHSLWLTFGMAVVTLLLEILGLAGPYQERLVTNSATMTANLNYALTHHSAYHVPYPYTANTLYHAFGTFGGTGMLLALVIAIYIGSNNHNYHVVARWSLLPALFNSNGPLLTGLPVLYNPIYLIPFVLAPVVNMGLAALAIGFHWIPPVVYPVPVGTPGPLIAFIGTNGNVVALLLGIVDLALSVVIYLPFMRLAETIVQAAQAQVGGAKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV6</accession>
    <name>F9UMV6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface hydrolase, DUF915 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641349.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889059.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1156"/>
    <dbReference type="EnsemblBacteria" id="CCC78545">
        <property type="protein sequence ID" value="CCC78545"/>
        <property type="gene ID" value="lp_1156"/>
    </dbReference>
    <dbReference type="GeneID" id="57024791"/>
    <dbReference type="KEGG" id="lpl:lp_1156"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.976"/>
    <dbReference type="eggNOG" id="COG4814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077377_1_0_9"/>
    <dbReference type="OMA" id="LGTPFNF"/>
    <dbReference type="PhylomeDB" id="F9UMV6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-987-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010315">
        <property type="entry name" value="DUF915_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06028">
        <property type="entry name" value="DUF915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="33727" checksum="50F82A381267396A" modified="2011-10-19" version="1">MYNRPNWQRRRRSLLVLVLGLLFLGFLIQPSYQWTKTNVAAMAGRHDSQMSPIIMIPGSSATQNRFDTLVKQLNKADHRRHSLIKLTVMTDDTIKMTGSLRARDNEPIIVVGFQNNRDGYDNIKHQARWFSLAFKKLAAKYQFNNFKAIGHSNGGLIYTYYFEHYFNRDDIKVKRIMTIGSPYNFSEANLNHKTQMLADFIKYRDRLPKSATMYSVAGTENYDSDGLVPARSVEAGKYIYQGQVKHFTEITVTGTNAQHSDLPQNAQIVTLIRTYMLDKPKQTRKGLVSTGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMW3</accession>
    <name>F9UMW3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
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                <person name="Li H."/>
                <person name="Cobb G."/>
                <person name="Joachimiak A."/>
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            <authorList>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Boekhorst J."/>
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                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
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            <begin position="215"/>
            <end position="233"/>
        </location>
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        </location>
    </feature>
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            <end position="334"/>
        </location>
    </feature>
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            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="441"/>
        </location>
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    </feature>
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            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="389"/>
            <end position="536"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="556" mass="61462" checksum="949D88D7D1F4E064" modified="2011-10-19" version="1">MSEESKANQPQNAHVNSEAEAHQKMVRGSAWMTAGSLFSRVLGAIYIIPWVIWMGADYTQGNALYAKGYNIYSFFLLIAIGGIPSAISKQLSEYNAMNEYAVGQRLFKRGLLLTSAFGIIGAIILWFGAGLISTAFGGYDANLIPVLHALAIALVILPSMSLTRGFFQGYQQMAPSAISQFVEQVFRVIYMLGATYFIMRVAHGDWVNAVTQSTFAAFVGAAASFLLLGWYYFRKRPELNALAAQSENKLVIPVWQLFRDIIIQAIPFIVIDTATTVFNLLDQATFQPMMRLVYHLGTKQIDTLYAYFAFNANKLVMIIVSLASAIAVTVVPILSESLASHNMRNIRKQLEDSIILFLFIMIPGALGMAAVAQPLNTLFYSYDQIGTLILQISAFTAIALGFFTVISALMQGLSRNRDIIRYYLIGLLVKIVIQLPCIYFLSTAGPLVATAIGMMVASLMAMYDLEVNFGIRYVKLLPKINRILVYSILTYVTARLVVYGLNFVLNEHSKTQSFLIVALAVIAGGAVYVYLALRSRMADLMIGTKAAGLRRKLRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UND1</accession>
    <name>F9UND1_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Extracellular protein, membrane-anchored</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_1371"/>
    <dbReference type="EnsemblBacteria" id="CCC78720">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_823346_0_0_9"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78720.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="356" mass="40151" checksum="52E05397CC87833E" modified="2011-10-19" version="1">MGWSLILKLICNSFWSELFMRTYLFIAGLILACLILIIILIAVLVHLHHVNQAADKQAALLKSIRQRLVHQTLTNQEQDRQITKLQTQNNGFRNRLNQAVPHPVAVPQTRRINANSRAIFRSYVIGLDYYQKEFEAALADASARGYFKPYGGYNDSGLKADYLYAKKYRVDANANIGEIQLVEEVDGAERSVRVELKVAEHGYTIGYLPKKQVDEAFNVIDIYANSVMTLSSKTNLTGGEWKMAIDAVDEMQYLNDPNAQNRALPDYGAIDTPLKIKTGKKSYFLQFTLYEMEISNDEIPLYSLVDTVDGQRGSIVEVDAGPISYVIDVQAGPQTGSKITVIPEQIDRVIWVPNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNK5</accession>
    <name>F9UNK5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">lp_1465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1465"/>
    <dbReference type="EnsemblBacteria" id="CCC78794">
        <property type="protein sequence ID" value="CCC78794"/>
        <property type="gene ID" value="lp_1465"/>
    </dbReference>
    <dbReference type="GeneID" id="49284186"/>
    <dbReference type="KEGG" id="lpl:lp_1465"/>
    <dbReference type="eggNOG" id="ENOG5030AVR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1255-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="54" mass="6066" checksum="E8167BCA4E172659" modified="2011-10-19" version="1">MALFINFLIIALIIGAAGYQIYRVVKRAKKGKCAACDYDCEAKKMLNKAQKQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR7</accession>
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        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">lp_1532</name>
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    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645187.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889370.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1532"/>
    <dbReference type="EnsemblBacteria" id="CCC78856">
        <property type="protein sequence ID" value="CCC78856"/>
        <property type="gene ID" value="lp_1532"/>
    </dbReference>
    <dbReference type="GeneID" id="57025127"/>
    <dbReference type="GeneID" id="66449423"/>
    <dbReference type="KEGG" id="lpl:lp_1532"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1290"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_2_9"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="PhylomeDB" id="F9UNR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1317-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="118" mass="13000" checksum="4CF7EB6855150907" modified="2011-10-19" version="1">MDSKELLQLTVEAADDKRADDIVALDVAEVSLMADYFVILSADSKRQVQAIADNIVDFVRKAGSDVKSVEGRTAGEWVLIDAGDVIVHVFQKDARAHYNLEKLWSDAPIVDVAQWVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNT7</accession>
    <name>F9UNT7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638562.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1557"/>
    <dbReference type="EnsemblBacteria" id="CCC78876">
        <property type="protein sequence ID" value="CCC78876"/>
        <property type="gene ID" value="lp_1557"/>
    </dbReference>
    <dbReference type="GeneID" id="57025146"/>
    <dbReference type="KEGG" id="lpl:lp_1557"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1310"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_9"/>
    <dbReference type="PhylomeDB" id="F9UNT7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1337-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="119" mass="13729" checksum="178C391BEC01D427" modified="2011-10-19" version="1">MSEMLADTVTESNVDFELCPKFEKTFSILGKKWNGLIIDVLLEDGPQRFKNLARRIPKCSDRVLVVRLKELEENGIVSRVTHCDSALIEYRLTTKGQDLRQVMDTVHNWSDKWFSPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU3</accession>
    <name>F9UNU3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889396.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1564"/>
    <dbReference type="EnsemblBacteria" id="CCC78882">
        <property type="protein sequence ID" value="CCC78882"/>
        <property type="gene ID" value="lp_1564"/>
    </dbReference>
    <dbReference type="GeneID" id="57025152"/>
    <dbReference type="KEGG" id="lpl:lp_1564"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1316"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081309_1_0_9"/>
    <dbReference type="OMA" id="VPSDWRV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1343-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="26666" checksum="9B90B90BFD5C2339" modified="2011-10-19" version="1">MHKNWFWPVFLIASAVVLIVSQLGLFTLHVSIWSLLLTLILVAALISSLRYLNMPGVVFAIAFLTMIYAQPLGITKLVPWTILGAAVLLSIGLGLLIHPRYQYHYRYHNHDHAHYNHHNHDDVHESTSTINDDHVNLDLSLGNSIRYVHSENFRSADLNVSMAGAKIYFDDADIKEGRATINVDVSLGSLELYLPQTWQLQENLSNSMGHISSTGTPTTAGPGVILTGSVSLGELRIIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV1</accession>
    <name>F9UNV1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <dbReference type="EnsemblBacteria" id="CCC78956">
        <property type="protein sequence ID" value="CCC78956"/>
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    <dbReference type="OMA" id="KWQDVTQ"/>
    <dbReference type="PhylomeDB" id="F9UP17"/>
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            <begin position="498"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="531" mass="59249" checksum="5F5250DB1E8CB4FD" modified="2011-10-19" version="1">MHKSQLRVLLAVNLRLLNPQLTDRLRKKGASGPALSKKLMRQFYLNALMFLGIYGLTMLAFDFSKLPGMFTFYVALFILLGISQSISGIYNVFFAGNDLVEYLPLPFRNQEIFMSKILVVIFNTVPFTIPLLLIFIMTATRAGIFVVLGVLMAVLMYGLILSVLLCLCALIVFGLTKLTVFRTHQKMVMNVMLGLNAVLVLVGLYFMNRGSSSDTGTQVDRAALPLLIPIFKVFTTPLTMTSLLTWASLIVISLILFALTGRFVLTHLAEQLTQVNSVLVATPPRRHSRQHNRNKILRTYQFQLLKEPSLALQLFTNSILLPLILVGTVLFSGTAPNFSRLSLNWLGVWFVSGMAGAIINVNQTSLVGNLISLDKMNFDFVRALPIPMSRYLRQKFYLGYWFQVMINGVMVLVVGIAGRAPLALDLALILGVAWGTYLAAQHYFKRDYQLRLTNWTNVTQLFNRGGGNLGLMLNLLACSIVGVLTIVIYSVLIKLFAAAAMLINIIVLVGVGIISAGLVWHYYKTFWQQLD</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC79022.1"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI7</accession>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79208.1"/>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889760.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1995"/>
    <dbReference type="EnsemblBacteria" id="CCC79246">
        <property type="protein sequence ID" value="CCC79246"/>
        <property type="gene ID" value="lp_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1995"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1686"/>
    <dbReference type="HOGENOM" id="CLU_1110326_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1710-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388087" evidence="2">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="250" mass="27091" checksum="D120BA1E1D0CB514" modified="2011-10-19" version="1">MKKVVTGAAIVASLFLMGGCSSSYSKSSQSSSSSVKISKSELSSKKSQKLEDATTDVDSLFSDSGHTALVPGTKKLLIDEVSKEVNKLTDSKGKSNLQKELKNAYVLYPKLASSVASSNAASNAKVRSESASESSVVLSVRESSSKRHLSSKRESSSSNADKYANKIMNLGVPTHATDVSYSNHTVTWTGFDAWKDYTHPELKKLIAFLETITYQQSPNYNQKSPKLIVTLSDGTQIAHEEPGRNLIWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW2</accession>
    <name>F9UPW2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889765.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2003"/>
    <dbReference type="DNASU" id="1061701"/>
    <dbReference type="EnsemblBacteria" id="CCC79251">
        <property type="protein sequence ID" value="CCC79251"/>
        <property type="gene ID" value="lp_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2003"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1692"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053651_1_1_9"/>
    <dbReference type="OMA" id="VDAFSCW"/>
    <dbReference type="PhylomeDB" id="F9UPW2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1715-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="375" mass="42931" checksum="B5CD88DDFC21D38B" modified="2011-10-19" version="1">MMETTQFNPIQLKRARVARGKTMKVLAEETGISRQMISNYELGKTVPSGLNLVKLISVLNFPKNYFSATQASNLHGATFFRSQNAATKRARDMQSVRLSFQNDIYTTLSQYVNFPKVDLPESLDMDVDDITNDNIKFMAMRVRDQWDLGTKTPIENLIQTAEIHGIVVVKTNMTNDKLDAVSEIIEGRPFIMLTDNGESAVRRRFNVAHELGHIVLHAGIESIHDFTSQQLKNTIERQANLFASTFLMPDDAFVESLLSTSLDYYIKLKQYWKASIQSMIYKTYQLGLINDDQKLYLNKKISWNKWRKIEPLDNILEIENPTLFGKVFNMIIDHKVVSQADLLSELKLPFDELECSLGIQLATQKNISEPKLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ50</accession>
    <name>F9UQ50_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 1 (GT1)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cps4F</name>
        <name evidence="3" type="ordered locus">lp_2103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640783.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UQ50"/>
    <dbReference type="STRING" id="220668.lp_2103"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="1061507"/>
    <dbReference type="EnsemblBacteria" id="CCC79339">
        <property type="protein sequence ID" value="CCC79339"/>
        <property type="gene ID" value="lp_2103"/>
    </dbReference>
    <dbReference type="GeneID" id="57025646"/>
    <dbReference type="KEGG" id="lpl:lp_2103"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1780"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_9"/>
    <dbReference type="OMA" id="PHAWSFE"/>
    <dbReference type="PhylomeDB" id="F9UQ50"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1800-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="363" mass="40142" checksum="48232BAE986A88A1" modified="2011-10-19" version="1">MKIVYIITQATWGGAQAHLYSLIKAQVMRGNAVALVYGVEGRLSASVAKEFQDVQVVRVASLVHPIAPLSDLKAIYTLRKLVKNWQPDIIHLHSSKAGMIGRLATIRLPMKVIFTVHGWGFTPGVGKKRQLLMKTIEKALSRLTTAYICVSQFDYDLGVQSGVITSAHPARVIHNGVTALTGANKATSSEVFVLSMAARFDTPKRQDILIQALTYLPENLPIVCHFLGDGPSIEACKTLTHQLNLDGKVNFYGVVDNVQKYYSQSDVGVLISDYEALPISLVEALAQGLPIIASNVGGIQELIDHNGFLVTNDARQIAEKILTLYQSKKIAEVKTNSYQMYQRHYTEHEMLEQTQAYYLRCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ74</accession>
    <name>F9UQ74_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComE operon protein 1, dCMP deaminase</fullName>
            <ecNumber evidence="8">3.5.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">comEB</name>
        <name evidence="8" type="ordered locus">lp_2130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889877.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2130"/>
    <dbReference type="EnsemblBacteria" id="CCC79363">
        <property type="protein sequence ID" value="CCC79363"/>
        <property type="gene ID" value="lp_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2130"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1804"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_1_9"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="PhylomeDB" id="F9UQ74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1824-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013404">
        <property type="entry name" value="Competence_ComEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02571">
        <property type="entry name" value="ComEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18186" checksum="7C31C2007FAE9907" modified="2011-10-19" version="1">MKDQRIPWDQYFMMQAVLLASRSTCERLSVGATIVRDKRIIAGGYNGSVSGDVHCIDEGCYLVDGHCVRTIHAEMNAILQCAKFGAATDGAEIYVTDFPCLQCTKMLLQAGIQKIHYLRNYHNDAYAMSLIERKHVALQQVQFDQSDLDKLNLDQILLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQD0</accession>
    <name>F9UQD0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division protein FtsL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsL</name>
        <name evidence="8" type="ordered locus">lp_2201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">Localizes to the division septum where it forms a ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FtsL family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2201"/>
    <dbReference type="EnsemblBacteria" id="CCC79419">
        <property type="protein sequence ID" value="CCC79419"/>
        <property type="gene ID" value="lp_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2201"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1860"/>
    <dbReference type="eggNOG" id="COG4839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160672_0_0_9"/>
    <dbReference type="OMA" id="QKSHNTD"/>
    <dbReference type="PhylomeDB" id="F9UQD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1880-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00910">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02209">
        <property type="entry name" value="ftsL_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="131" mass="14171" checksum="E553B376EF2644CC" modified="2011-10-19" version="1">MIKMAQNGLARELPQQTPGATTPVHKTKTVVTPNPSIKTQRVAFSLFEKVLCVGLSLVVFGLAIMLVSTNIATSNAQSQLQTVQTKVTKVQAKNTSAAQEISELSSRSRLNKIAKQYGLSLNNGSIRNVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH4</accession>
    <name>F9UQH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889977.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_2254"/>
    <dbReference type="EnsemblBacteria" id="CCC79463">
        <property type="protein sequence ID" value="CCC79463"/>
        <property type="gene ID" value="lp_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2254"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1906"/>
    <dbReference type="eggNOG" id="COG1416">
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    <dbReference type="PhylomeDB" id="F9UQH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1948-MON"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
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    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="106" mass="11125" checksum="7E1B3E454CF45896" modified="2011-10-19" version="1">MTNLVVHVDEPAKVATAISNVQNFLAARPTSTVVVVVNGPAITTLATGAWKPLQQTLPQVEIDACHNAMVSHQMTAAQLPASVTVVPAGVVRIVDLQAVGYAYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH6</accession>
    <name>F9UQH6_LACPL</name>
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        <recommendedName>
            <fullName evidence="1 5">Catabolite control protein A</fullName>
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    <gene>
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        <name evidence="7" type="ordered locus">lp_2256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UQH6"/>
    <dbReference type="STRING" id="220668.lp_2256"/>
    <dbReference type="EnsemblBacteria" id="CCC79465">
        <property type="protein sequence ID" value="CCC79465"/>
        <property type="gene ID" value="lp_2256"/>
    </dbReference>
    <dbReference type="GeneID" id="57025802"/>
    <dbReference type="GeneID" id="66450014"/>
    <dbReference type="KEGG" id="lpl:lp_2256"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1908"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_9"/>
    <dbReference type="OMA" id="HSEFVFM"/>
    <dbReference type="PhylomeDB" id="F9UQH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1950-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CollecTF" id="EXPREG_00000450"/>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription repressor activity"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CcpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
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        <property type="entry name" value="HTHLACI"/>
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    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="6">
        <location>
            <begin position="6"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="36330" checksum="169B1381BE7DCDE6" modified="2011-10-19" version="1">MEKQTVTIYDVAREAAVSMATVSRVVNGNPNVKPATRKKVLAVIERLDYRPNAVARGLASKRSTTVGVIIPDVTNIYFAALARGIDDIAMMYKYNIILTNSDDAGEQEVNVLNTLMAKQVDGVIFMGNHIDDKLRAEFKRAKAPVVLAGTVDPNNETPSVNIDYAAAVEEVVTNLIARGHKKIALALGSLSQSINAEYRLTGYKRALTKAKIPFDDALVYEAGYSYDAGRKLQPVIADSGATAVFVGDDEMAAGLINASMESGINVPDDLEVVTSNDTIITQITRPAITSITQPLYDIGAVAMRMLTKLMNDKELDEKTVTLPYGIVRRGSTKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Prophage P2a protein 16</fullName>
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    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101771.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2441"/>
    <dbReference type="EnsemblBacteria" id="CCC79619">
        <property type="protein sequence ID" value="CCC79619"/>
        <property type="gene ID" value="lp_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2441"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2063"/>
    <dbReference type="eggNOG" id="ENOG5032PQW">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568773_0_0_9"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="169" mass="19267" checksum="3B3E1EB33862F45D" modified="2011-10-19" version="1">MIKEETAGMTLDEMEVKLEQATRDKKAFKKAMLKPQMEVDKYRKAIKTVDEQIDQLQELQRMAMGDQEQVDTEFFHFKMGTVNPSTSRNWNLERDKDATPKELTAVFERFDDTLIKTSRSVNETEIKNRLASGELYVTPDGKIMDSSLKALPGYSGALKKPKISVKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR01</accession>
    <name>F9UR01_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2b protein 15, terminase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890154.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2466"/>
    <dbReference type="EnsemblBacteria" id="CCC79640">
        <property type="protein sequence ID" value="CCC79640"/>
        <property type="gene ID" value="lp_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2466"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2078"/>
    <dbReference type="eggNOG" id="COG4626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026632_6_1_9"/>
    <dbReference type="OMA" id="QWVEMLT"/>
    <dbReference type="PhylomeDB" id="F9UR01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2132-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005021">
        <property type="entry name" value="Terminase_largesu_Lambdalike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41287">
        <property type="entry name" value="PTHR41287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03354">
        <property type="entry name" value="Terminase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="567" mass="64933" checksum="AA32582FAC437BFF" modified="2011-10-19" version="1">MIEYVDQVLSGQVLAGQKIKWACERFKRDLSRSKDDSFPFYYDEDKAAQAVKFIELMPKTDGSQLTMQPFQKWIISELYGWREKTTGNRRYDRAFISMARKNGKTYLASGMAANGLLRERQPARNRQVLFVSNALKQAKLGYDMLSSGLRQVRKQSKYMRQRIKVQKQAITDLETDSQALALASDTSTLDGYAGTTVILDEWHEAKDRKVYNVLKSGQAQEDNSLLAVISTSGLNLNVPMHAEYDMLTDVLKGKTEADRYFVAIWELDDREEVYDQANWIKANPLFSEPHVKQRMTEKIQADVDLAIKQNNLIPILVKNFNMWLQASEDSYISADDWAAGKLAKVPDLHNRVAYIGIDLSKSNDLTAVSWLIPIGNGQFYCDSHSFIGIKYGLSSKIKRDGIDYRSMERAGECSITRLDSGIIDYDDLFDFVQKLIGKYNWKVKAIAYDPYNSQTLITKFEKLNYPLFEVRQGTKTLNIPTRNFRDQLYDNKIKHNGNKILAYAVNNAILKVLNNGWQLDKARNSNRIDPIAALINAFVAGMDYYQESEDQQHAEDYYKTATMADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR23</accession>
    <name>F9UR23_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2488d</name>
        <name evidence="2" type="ORF">lp_2488e</name>
        <name evidence="3" type="ORF">lp_2488f</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="1">WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
            <strain evidence="1">WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890176.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890177.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2488d"/>
    <dbReference type="EnsemblBacteria" id="CCC79662">
        <property type="protein sequence ID" value="CCC79662"/>
        <property type="gene ID" value="lp_2488d"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79663">
        <property type="protein sequence ID" value="CCC79663"/>
        <property type="gene ID" value="lp_2488e"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79664">
        <property type="protein sequence ID" value="CCC79664"/>
        <property type="gene ID" value="lp_2488f"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2488d"/>
    <dbReference type="KEGG" id="lpl:lp_2488e"/>
    <dbReference type="KEGG" id="lpl:lp_2488f"/>
    <dbReference type="eggNOG" id="ENOG5032P7Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169537_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2154-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2155-MON"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2156-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="43" mass="4769" checksum="FADFE211D16D2D04" modified="2011-10-19" version="1">MSFFNDFHVLPGTHTSSYTSSVSNDIFGGFHSFVLNLIAAFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB1</accession>
    <name>F9URB1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101850.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2603"/>
    <dbReference type="DNASU" id="1062840"/>
    <dbReference type="EnsemblBacteria" id="CCC79750">
        <property type="protein sequence ID" value="CCC79750"/>
        <property type="gene ID" value="lp_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2603"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2186"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_2_1_9"/>
    <dbReference type="OMA" id="ERENNHY"/>
    <dbReference type="PhylomeDB" id="F9URB1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2241-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="32492" checksum="1927F6EC6AC81AC5" modified="2011-10-19" version="1">MQLIEQLSHRSDFTTTETRIATYILSHQDAMPNILIKELAAKTYTSHSAIIRLAQKLGFHGFRDFQRALTTEIVINTQATTNVDANFPFTDKDAVTEIIKKMADLKTNAIANAQHQLRPEVLTKSAYLLNKARHIMLFSQGDSQLRARSFQNKLVKINRFAQIAEMYADEAWNIASLTPQDCAMFISYAGNTDVHQRFAKYCQAHHIPVIVLTGNVDSPLQQFATYQLVITQNERNNAKLGTFASQVSFDYVLDTLFAIMYANNFQTNLAHLKTTQLLIQDGTLQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URB6</accession>
    <name>F9URB6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890269.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2612"/>
    <dbReference type="EnsemblBacteria" id="CCC79755">
        <property type="protein sequence ID" value="CCC79755"/>
        <property type="gene ID" value="lp_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2612"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2194"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_12_1_9"/>
    <dbReference type="OMA" id="ICGTLAN"/>
    <dbReference type="PhylomeDB" id="F9URB6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2246-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20357" checksum="AC32DF9ED4E326BA" modified="2011-10-19" version="1">MASHQALLIIDYTNDFVADGGALTCGQPGQALAPTIVKLANQMATASDWVLLPTDVHTPHDPYHPESKLFPPHNVRGTWGRELYGPLKDWYADHQAADNVWAFDKTRYSSFAGTDLDLRLRERHVDTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDAVASFDAAGHEWALRHFKNSLGATIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
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    <name>F9URC5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">lp_2623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890278.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2623"/>
    <dbReference type="DNASU" id="1062861"/>
    <dbReference type="EnsemblBacteria" id="CCC79764">
        <property type="protein sequence ID" value="CCC79764"/>
        <property type="gene ID" value="lp_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2623"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2203"/>
    <dbReference type="eggNOG" id="ENOG5032Y99">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084734_0_0_9"/>
    <dbReference type="OMA" id="NAYWSKA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2255-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="32234" checksum="8F6B420360B27702" modified="2011-10-19" version="1">MNPKKLKQLKKRVKKQAGAPYIQQLMKYRDLFKDDPQILVLINNVLESDRLLAAGLAPQQLPVLEIPDDFQDHLFERINQQYAMGDPAGDAAWNQLSAALPKVDQLLRNFRDYIEDQYGMWAYISAPFLKDLADFTGSAPVLEVMAGNGYISKGLKRLHPGQPIYTTDSKDWTHETGNQTGRHPVTTIEALDAVSAFNKYAATIKYVIMAWSPDKLTIDWDLLQAMRQSPYDIPLIVIGEKYGATGSKQFWDHANYQDNEAVTKLNAHFRPFDLIHDHVYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9URH8</accession>
    <name>F9URH8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orotate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">oroP</name>
        <name evidence="2" type="ordered locus">lp_2696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101884.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890331.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2696"/>
    <dbReference type="EnsemblBacteria" id="CCC79817">
        <property type="protein sequence ID" value="CCC79817"/>
        <property type="gene ID" value="lp_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2696"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2256"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068878_0_0_9"/>
    <dbReference type="OMA" id="WQQAVNG"/>
    <dbReference type="PhylomeDB" id="F9URH8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2308-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="369" mass="40038" checksum="72132A15E3F0920A" modified="2011-10-19" version="1">MAGIFKIVMKIKLDYPDDFHDYFSYRLVLILTCDRLLRQDKEMREYSMLAILVGLAIGIGLPMQTSINSRLRNSVGSPFGASLISFAVGTLFLAIMTLIDVHTLGFSTTLFTSQPVWIWLGGLLGVVYLTGNILLFPKLGSVQTVIMPVLGQILAGLLIDNFGWFDSPQSTLTMTRFLGAILVLAGVIITVAAQGWLEQRHNRITETAEKDTATDTDTDQSGLGIWRALGVVAGMLSAMQTAVNGHLGRVLGSTVHAAFVSFLVGTLGLIVIVLVLRPQFKLIRPTKTPNPWWMWIGGMIGALYVLGNVYLVPVVGTGLAVVIVLVGLMAGSLMIDQFGWFASKKNPISGVQLMGLLVMIVGVVLIRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URJ0</accession>
    <name>F9URJ0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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    </organism>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <evidence type="ECO:0000259" key="1">
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
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                <person name="Ursing B."/>
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            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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    <accession>F9URN7</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
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    <reference key="2">
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
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                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="363" mass="40737" checksum="5B55BFE9C9831311" modified="2011-10-19" version="1">MSKLGVSVYPERSTFEKDAAYLDLAAKYGYQRVFTSLLEIKGDQAAVVANFKKVITYANQLGLQVMVDVNPDLFKQLGVSYDDLSFFHDLGAWGVRLDLGFTGQEEARMTHNEFGIKIEVNMSKGTHYVDTIMDYSPEKDNLLGSHNFYPQQYTGLGYDYFVQTSEQYRQYGINTAAFVSSNDATYGPWPMQDGLCTLEDHRGLPIAAQVQHLKMTGLIDDVLIGNAYASEAELKAAAEVFFSPYPLLHVETVADLSAVEEKVLFAQPQTYRGDFSDYVIRSSQTRVIYKDEAFPAHHLDAIHTGDVLIDNDEFGQYKGELQIARQNLENTGRINVVGHITKSDLPCLNLLQPWADFKFVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9URP1</accession>
    <name>F9URP1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nadC2</name>
        <name evidence="12" type="ordered locus">lp_2771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101911.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890394.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2771"/>
    <dbReference type="EnsemblBacteria" id="CCC79880">
        <property type="protein sequence ID" value="CCC79880"/>
        <property type="gene ID" value="lp_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2771"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2320"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_2_1_9"/>
    <dbReference type="OMA" id="TDTFAIQ"/>
    <dbReference type="PhylomeDB" id="F9URP1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2371-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="357"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="477" mass="51997" checksum="8DAABF62927B6AD3" modified="2011-10-19" version="1">MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFHFTNSDLDYFRQLNLWDESFLAMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLLETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQGPDSALYGTRAAIIGGANSTSNVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAVTVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLHEGAPIDNFGIGEKLITSASAPVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVYRLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDRQQRLTRFEARPLLAPVDLSNTTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR9</accession>
    <name>F9URR9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101922.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890422.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2804"/>
    <dbReference type="EnsemblBacteria" id="CCC79908">
        <property type="protein sequence ID" value="CCC79908"/>
        <property type="gene ID" value="lp_2804"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2804"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2348"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_28_0_9"/>
    <dbReference type="OMA" id="HEHTLAK"/>
    <dbReference type="PhylomeDB" id="F9URR9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2400-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="299" mass="33986" checksum="360DD047A2E3D352" modified="2011-10-19" version="1">MIENYLLEELITFAHEHTLAKTAAALNVTQPTITRGMQKLETMLAVRLFDRQPNRITLTPTGQLAAQEAEQLLTQRRTFVTKIQNYEQSLVTRTVETTLPGPLALLTHLKTVLPNSLRVRQPLIADDQITEHLINRQASFIFSNQEILTAGIESRFIGTENLVVHLQRFMYRANQPSITFAELKGISFVVLSAIGIWKDIIQQAIPDAKFLYQPQRTAFTEITKYSDFPYFSTNFTALAPHQLDSQADDDNRVAIPISDTRAHMPIYVNYLVSNRQSLMPLFKQFEAAWPANLKHTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS9</accession>
    <name>F9URS9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1440 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890432.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2820"/>
    <dbReference type="EnsemblBacteria" id="CCC79918">
        <property type="protein sequence ID" value="CCC79918"/>
        <property type="gene ID" value="lp_2820"/>
    </dbReference>
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    <dbReference type="GeneID" id="66450458"/>
    <dbReference type="KEGG" id="lpl:lp_2820"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2359"/>
    <dbReference type="eggNOG" id="COG3477">
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    <dbReference type="HOGENOM" id="CLU_095313_0_1_9"/>
    <dbReference type="OMA" id="WIAFHLV"/>
    <dbReference type="PhylomeDB" id="F9URS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2415-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009898">
        <property type="entry name" value="DUF1440"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07274">
        <property type="entry name" value="DUF1440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="167" mass="18217" checksum="2C9BE025584D73CB" modified="2011-10-19" version="1">MVNKQFNHRAAVIAGVTGGVISGLVKLGWENILPPRTPQRDQTNPPQQLLQQIGIPASVTHATYSYSGHDLPGVSYVMHFGFSTTFAVAYSLWARKHPRAKGGSSALYGLGIWTAFHHGILPALGTVPAAKDQPMTEHVSEAIGHVLWMWTADWVSAAVYDRMTRSK</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642181.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890498.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2903"/>
    <dbReference type="EnsemblBacteria" id="CCC79984">
        <property type="protein sequence ID" value="CCC79984"/>
        <property type="gene ID" value="lp_2903"/>
    </dbReference>
    <dbReference type="GeneID" id="57026257"/>
    <dbReference type="GeneID" id="66450519"/>
    <dbReference type="KEGG" id="lpl:lp_2903"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2426"/>
    <dbReference type="eggNOG" id="COG0640">
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    <dbReference type="OMA" id="WHIYSIN"/>
    <dbReference type="PhylomeDB" id="F9URZ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2480-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
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    </dbReference>
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        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHARSR"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="109" mass="12747" checksum="514EEF6F2724F3D9" modified="2011-10-19" version="1">MVSSEEALQEFRETIPIFEVLADERRQQIMIELSQHAQGMTVGELTERMHISQPAVSHQLKTLKERHFVAVEHQGTRNYYRVTFDAPLTQVEHLIHTLKADLELKPYLH</sequence>
</entry>
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    <accession>F9US55</accession>
    <name>F9US55_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641650.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0026"/>
    <dbReference type="EnsemblBacteria" id="CCC77602">
        <property type="protein sequence ID" value="CCC77602"/>
        <property type="gene ID" value="lp_0026"/>
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    <dbReference type="GeneID" id="57026887"/>
    <dbReference type="KEGG" id="lpl:lp_0026"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.24"/>
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    <dbReference type="OMA" id="FVTMNGQ"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="255" mass="28753" checksum="AACD9EB158037BF9" modified="2011-10-19" version="1">MYQAVVFFDLDGTLMQDDKTVAASSVRAIQQLRANHVLPVIATGRNVFEVQDVMTTTGIDSIVSANGSYVAYQGQFLSAHELDKELLTDITHFANRQQNALAYYNNAGFALSHRDALTTSNYRALRQTARVAPHFYEHQHINFLLTFDPLNAAQYRQRYRGRLHFVRNNPRALDTMQWGVSKAVGIQDILTKAHLTKVPTYAFGDQLNDIEMFRMIQTPIAMGNGHPQVKQLARYVTADNMHGGIAQGLQHFDLI</sequence>
</entry>
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    <accession>F9USI7</accession>
    <name>F9USI7_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Fe-S cluster biosynthesis protein</fullName>
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    <gene>
        <name evidence="2" type="ordered locus">lp_3070</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102029.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3070"/>
    <dbReference type="EnsemblBacteria" id="CCC80117">
        <property type="protein sequence ID" value="CCC80117"/>
        <property type="gene ID" value="lp_3070"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3070"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2564"/>
    <dbReference type="eggNOG" id="ENOG50309SE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141575_1_1_9"/>
    <dbReference type="OMA" id="PNMVMDY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2610-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="131" mass="14252" checksum="CE09FEFDF8110822" modified="2011-10-19" version="1">MTQIEISDWLKALLVAKGFDKKQLVLVTDDGGGKYSLHGGACSIGTKFTIIVLDQPDPEYNVTVVNDQGLALWTSTYDLIFFNDGIKMDYDQGRIAIKDNAHMLDNAVQIAKGAEVLAAFEQGVPADNLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL5</accession>
    <name>F9USL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transport protein, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">lp_3101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890659.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3101"/>
    <dbReference type="EnsemblBacteria" id="CCC80145">
        <property type="protein sequence ID" value="CCC80145"/>
        <property type="gene ID" value="lp_3101"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3101"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2591"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_9"/>
    <dbReference type="OMA" id="QNIGSAF"/>
    <dbReference type="PhylomeDB" id="F9USL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2638-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="14"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="492" mass="52618" checksum="6BBF6B5D94A85ADC" modified="2011-10-19" version="1">MQAKAKISKATMTIAWVVVFGAMAPLLDSTMINIAINNLVTSFHSSVTTVQWAVTGYLLATGVAVPFSSWLLNRFDGKAVFVAGEILFGLGSIFAAVAPNIQLLIIARLVQGFAGGLIMPLLTTLLVQTAGAAVMGQMMATVGLPMILGPLIGPVIGGIIIKFASWHWIFWINVPVVLISIALILWKMPNYPAQNRTAKMDFIGILLLIVSSSAIIYSLVNAAHTDRFNNATSIEMLILGAIALISYVVWAAWQKERAVVPLHLFKFASFDGAGLGLFIAGTVLNGAMLLLPLYFQNVRGMSVINAALALLPQGAGMLVSRTLTGRLTDQIGAKYVVLGSVVITFVGTLPFYWFGQQTSYWILALILFVRGIGAGGILMPLMADAYTGMQPGQVPAATIGTRIIQNIGSAFGSALITAIVTAYSTHQVNVFERHLKAETYHVDAAHLQVFTTSHLQAIRLAAFQQGFLVIAIAAIVIILPTLLLTNKLKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM7</accession>
    <name>F9USM7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mucus-binding protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_3114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102047.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USM7"/>
    <dbReference type="STRING" id="220668.lp_3114"/>
    <dbReference type="EnsemblBacteria" id="CCC80157">
        <property type="protein sequence ID" value="CCC80157"/>
        <property type="gene ID" value="lp_3114"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3114"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2603"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236206_0_0_9"/>
    <dbReference type="OMA" id="WANGQEQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2650-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041277">
        <property type="entry name" value="MBG_Lactobacillales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041495">
        <property type="entry name" value="Mub_B2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041558">
        <property type="entry name" value="MucBP_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17883">
        <property type="entry name" value="MBG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17966">
        <property type="entry name" value="Muc_B2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17965">
        <property type="entry name" value="MucBP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389010" evidence="2">
        <location>
            <begin position="48"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="domain" description="MBG" evidence="3">
        <location>
            <begin position="225"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="MBG" evidence="3">
        <location>
            <begin position="331"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MBG" evidence="3">
        <location>
            <begin position="847"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1302"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1410"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1506"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1618"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP_2" evidence="4">
        <location>
            <begin position="1713"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="Muc_B2" evidence="5">
        <location>
            <begin position="1800"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1979"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1905"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1985"/>
            <end position="1999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="2032" mass="214765" checksum="00BF6BBA93353DD4" modified="2011-10-19" version="1">MQRRRLQRAQLTEKRTYKMYKKGRLWLIAGLSTFTLGASLLPMTGRADTTSTPAEKQGTRTETTGNQITLASKSVGSSSMANDGEEKTNNSQVETSSEASNVTASTEAKSTESTTQTVVDSTVTSTATETTRANGATNQTSKMSIVDTTSNNTEQNQAVGGTTDSTASTATIEDQAKAANRATTDGKINTATVATKTTTTASYATADISTNTIRSAQKLARATVATVATVNSATKTYDGKIDTPNRYTITLTDGTKAPSDWAVTSTANVYTVTDLTDVDTSKFGSSVGTYTLALSTAGITKLAEANSSADITAANVVTGTLTIKQAPVPTAIITIGSASIDYGDAKPSTYTITVPSQYAVPSTWTLASSATDGTTNTYMIASSSGDVIVPTATQSGTYQLVLSDQGLTALQQANPNAAITADTIIAGSLVIAAHDIITMGATTIVVNKTTSTVPVTVNSRTIVVPTGWTIRYDDIQTDAIVYDVPVSDTTYSEAVNTAVVDKYTITLTDDTIETLANLNSSTTFNSTTVGKGVVLVKASAAVAISPANYGAQASAETPVTGLTISHARTKGIDLAYGQALYLILPLINMNPSGMTVANLTDYVIIPSGFKVATNSEGAINIATDPSSVLTSAIEAMMTKNDVTYQGLKVTQLTDYRGRQTFKIHFDKTTVYDGGAFATLKYALLPVIAVQNTGVTSGLIGNQVSSPDSAVVYVTDDSNENNGSYSLNLQNYTNIDSVADALGIADAVTIGSGFTSYLYHYTLSAKTITDTYSLVGNDGTSLGEVTFTGDSGKTYVPMTKLPMTITQNGVTYYLNTSAVSLTQTYSGDSNSNYTVTYQRYVTTTTDTAAKITIAPASKVYDNNATTDPSRYTVYLPTEYTAPSDWTADSAATAVDGTTAYQVSTDYLNTTAIDQNVGTYAVTLNSAGMAALSAANPDFLIAGDVNVGGTLTITQRPVTITLPDTILWANGQEQNITPVITGVVAVQSLDYTLTSGLTDPDTTTITATLTNAAANSNYKLTNSPSGQLTVGAVTVVYQYGYRDKAGTLHVVTTANGTATHGTDVTAKDYLSYTTSDTTATHAKTGYTLQPESTGYQADGTLADVGGQVVYTYLANTEKIAVVYVDQDKNNVILKQIPLSGSFGTPTNYTTAQDIAAYEKLGYVLASDKVPAPLEFDQDTEQTYYVYLKHGTITATVDQPGNVAVSDLMKTSQRTIHYVYADNTPTDLADVLQTVTYTRTATGDAVDRTVLSYGNWTTNVNSYPAIESPTITGYTADQTTIAAAVPASMGETTETTVRYSVNSETIRVQFVDGTTDNQVLSYIDLNGKYGDAADYTVTADIAKYAKLGYEPVNSDLPDQLIYKQNTQVYTVTLAHRHVTVSVDHPGQPGQAIDADYPAGPKYPAGTGRDSLEQTVTRTITYQYASGESAAETVNQSVTFNRTATFDMATGKQLTYGDWTVAPGQSALLAAVTSPTITGYQASVTEVEAASVTSHDKPHLIAITYTAKSQTATVAFVDVTSGKTLPTTVVTGAYGTTNSYSPVSQIAAYEKLGYRLVSNNVPTTGITFDQNDVIKSYTVKLAHQMTTVTPTKPGQPGQPVDPAHPEGPKYPAGTGLKDLTTSVQRVITYVYNDGQTAAPTVTQTVSFERKATFDQVTKVVTYTDWRTPESALTGAYAVVESPIIAGYTPNATRVASVTVSAKDTESRQTVTYQANLETATVTYVDATTGHRLGTSVTLTGRFGTQADYQPTTMIAQYTQAGYVLMGSDYPATGVTFNQAGVVQKYTVYLAHNKIVITAPDQLTKTITQTVHYQDQAGHTLQADTIRALTFTRSGMKDAVTGVATYRDWAPTGLNFTAVSAPTIAKYHALTATTQAVAITAASADDVQTLTYALDVPTPTKPVKLTKPAKPTKPTTSDDLIKPTTKPITAAKPTQLTKPATVVKDFQATTGNQTPAKSTRTLVSSRIKAVKTAPASAIIKPGSKVTEPAHKAQADTTSRLPQTGETRWSEMAAETLGLTLATLLLGFGGLKRKRHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR2</accession>
    <name>F9USR2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease, drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888157.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0078"/>
    <dbReference type="EnsemblBacteria" id="CCC77643">
        <property type="protein sequence ID" value="CCC77643"/>
        <property type="gene ID" value="lp_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0078"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.65"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_6_0_9"/>
    <dbReference type="OMA" id="MQTVWMG"/>
    <dbReference type="PhylomeDB" id="F9USR2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-65-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="152"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="31805" checksum="8AE7EF1BC4758750" modified="2011-10-19" version="1">MKKIAPLFVGLGAISFGIPASLFKIARRQGVVNGPLLFWSFLSAVVILGVIQILRRARLRNQQTNWKQIGLVIAAGTASGFTNTFYIQALKLIPVAVAAVMLMQAVWISTLLGAVIHHRRPSRLQVVSIVLVLIGTILAAGLFPITQALSPWGLMLSFLAACSYACTMQFTASLGNNLDPLSKTWLLCLGAFILIAIVWSPQLVTAPTTPATVGWGVLIALFSMVFPLVMYSLFMPYLELGIGPILSSLELPASIVVAFVLLDETIDWVQMVGVAIIITAVILPNVLNMRRVRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS9</accession>
    <name>LARA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lactate racemase</fullName>
            <shortName evidence="8">Lar</shortName>
            <ecNumber evidence="3 5">5.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 11">Lactate racemization operon protein LarA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">larA</name>
        <name evidence="11" type="ordered locus">lp_0104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6750" last="6761">
            <title>Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Goffin P."/>
                <person name="Deghorain M."/>
                <person name="Mainardi J.L."/>
                <person name="Tytgat I."/>
                <person name="Champomier-Verges M.C."/>
                <person name="Kleerebezem M."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="16166538"/>
            <dbReference type="DOI" id="10.1128/JB.187.19.6750-6761.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="J. Bacteriol." volume="197" first="219" last="230">
            <title>Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Bakouche N."/>
                <person name="Diman A."/>
                <person name="Viaene E."/>
                <person name="Dandoy D."/>
                <person name="Fontaine L."/>
                <person name="Hallet B."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="25349156"/>
            <dbReference type="DOI" id="10.1128/JB.02192-14"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="5598" last="5603">
            <title>Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
                <person name="Hausinger R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27114550"/>
            <dbReference type="DOI" id="10.1073/pnas.1600486113"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2015" name="Science" volume="349" first="66" last="69">
            <title>METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Zhang T."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
                <person name="Hu J."/>
                <person name="Hausinger R.P."/>
            </authorList>
            <dbReference type="PubMed" id="26138974"/>
            <dbReference type="DOI" id="10.1126/science.aab2272"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 2-424 IN COMPLEX WITH (SCS)NI COFACTOR</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF ASP-72; ARG-75; HIS-108; HIS-174; LYS-184; HIS-200; GLN-295 AND LYS-298</scope>
        <scope>REACTION MECHANISM</scope>
        <scope>ACTIVE SITE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 5">Catalyzes the interconversion between the D- and L-isomers of lactate (PubMed:24710389, PubMed:26138974). May act as a rescue enzyme to ensure D-lactate production in physiological conditions where its production by the D-lactate dehydrogenase LdhD is not sufficient (PubMed:16166538). D-Lactate is absolutely required for growth of L.plantarum and is an essential component of the cell wall peptidoglycan in this species, where it is incorporated as the last residue of the muramoyl-pentadepsipeptide peptidoglycan precursor; its incorporation confers high level of vancomycin resistance (PubMed:16166538).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>(S)-lactate = (R)-lactate</text>
            <dbReference type="Rhea" id="RHEA:10960"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="EC" id="5.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:137373"/>
        </cofactor>
        <text evidence="3 5 6">Was originally shown to use Ni(2+) as a cofactor (PubMed:24710389), but in fact, the cofactor is a (SCS)Ni pincer complex, a nicotinic acid mononucleotide derivative that is covalently attached to Lys-184 and forms a tridentate pincer complex that coordinates nickel through one metal-carbon and two metal-sulfur bonds (PubMed:26138974, PubMed:27114550).</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="3 5 6">Activation of the apo-enzyme requires the three accessory proteins LarB, LarE and LarC, that are involved in the biosynthesis of the nickel-pincer cofactor of LarA (PubMed:24710389, PubMed:27114550). Inhibited by sulfite that behaves as a mixed inhibitor (PubMed:26138974).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">46 mM for L-lactate</KM>
            <KM evidence="3">11 mM for D-lactate</KM>
            <text evidence="3">kcat is 4745 sec(-1) for conversion of L-lactate to D-lactate. kcat is 1333 sec(-1) for conversion of D-lactate to L-lactate.</text>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3 4">Induced by L-lactate and repressed by D-lactate. The lactate racemase activity is thus regulated by the L-lactate/D-lactate ratio, under the control of the transcriptional regulator LarR. Makes part of the lar operon (larABCDE).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Deletion of this gene leads to a loss of lactate racemase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the lactate racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="5HUQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A/B=2-424"/>
    </dbReference>
    <dbReference type="PDB" id="6C1W">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B/C=1-424"/>
    </dbReference>
    <dbReference type="PDBsum" id="5HUQ"/>
    <dbReference type="PDBsum" id="6C1W"/>
    <dbReference type="AlphaFoldDB" id="F9USS9"/>
    <dbReference type="SMR" id="F9USS9"/>
    <dbReference type="STRING" id="220668.lp_0104"/>
    <dbReference type="DNASU" id="1061369"/>
    <dbReference type="EnsemblBacteria" id="CCC77660">
        <property type="protein sequence ID" value="CCC77660"/>
        <property type="gene ID" value="lp_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0104"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.84"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_9"/>
    <dbReference type="OMA" id="GSVEPHY"/>
    <dbReference type="PhylomeDB" id="F9USS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-82-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-19498"/>
    <dbReference type="BRENDA" id="5.1.2.1">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000441651" description="Lactate racemase">
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            <begin position="1"/>
            <end position="424"/>
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    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="174"/>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="72"/>
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        <ligand>
            <name>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide</name>
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        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="5 6">
        <location>
            <position position="184"/>
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        <ligand>
            <name>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
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        <ligand>
            <name>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide</name>
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        </ligand>
        <ligandPart>
            <name>Ni</name>
            <dbReference type="ChEBI" id="CHEBI:28112"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
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        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="mutagenesis site" description="Shows residual catalytic activity in vivo." evidence="5">
        <original>D</original>
        <variation>A</variation>
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            <position position="72"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Retains some catalytic activity in vitro. Exhibits reduced Ni content." evidence="5">
        <original>R</original>
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            <position position="75"/>
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    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity." evidence="5">
        <original>H</original>
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            <position position="108"/>
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    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity. Exhibits reduced Ni content." evidence="5">
        <original>H</original>
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    </feature>
    <feature type="mutagenesis site" description="Shows residual catalytic activity in vivo. Loss of Ni binding." evidence="5">
        <original>K</original>
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            <position position="184"/>
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    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity." evidence="5">
        <original>H</original>
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        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Retains some catalytic activity in vitro. Exhibits reduced Ni content." evidence="5">
        <original>Q</original>
        <variation>A</variation>
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity." evidence="5">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="298"/>
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    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="2"/>
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        <location>
            <begin position="11"/>
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            <begin position="19"/>
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        <location>
            <begin position="51"/>
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    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="26138974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5HUQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6C1W"/>
        </source>
    </evidence>
    <sequence length="424" mass="46239" checksum="063CD5E0D19710D5" modified="2011-10-19" version="1">MVAIDLPYDKRTITAQIDDENYAGKLVSQAATYHNKLSEQETVEKSLDNPIGSDKLEELARGKHNIVIISSDHTRPVPSHIITPILLRRLRSVAPDARIRILVATGFHRPSTHEELVNKYGEDIVNNEEIVMHVSTDDSSMVKIGQLPSGGDCIINKVAAEADLLISEGFIESHFFAGFSGGRKSVLPGIASYKTIMANHSGEFINSPKARTGNLMHNSIHKDMVYAARTAKLAFIINVVLDEDKKIIGSFAGDMEAAHKVGCDFVKELSSVPAIDCDIAISTNGGYPLDQNIYQAVKGMTAAEATNKEGGTIIMVAGARDGHGGEGFYHNLADVDDPKEFLDQAINTPRLKTIPDQWTAQIFARILVHHHVIFVSDLVDPDLITNMHMELAKTLDEAMEKAYAREGQAAKVTVIPDGLGVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9USV2</accession>
    <name>F9USV2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100899.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0130"/>
    <dbReference type="EnsemblBacteria" id="CCC77683">
        <property type="protein sequence ID" value="CCC77683"/>
        <property type="gene ID" value="lp_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0130"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.107"/>
    <dbReference type="eggNOG" id="ENOG50330UE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103763_0_1_9"/>
    <dbReference type="OMA" id="THYALTC"/>
    <dbReference type="PhylomeDB" id="F9USV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-105-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021560">
        <property type="entry name" value="DUF3021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11457">
        <property type="entry name" value="DUF3021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="151" mass="17234" checksum="76028E03C0F2D1D2" modified="2011-10-19" version="1">MKRLWHTLLIGAIGGIVIGYLMALGFSTFFNTTYLFPSNPTFVSHWSSPLAATQLSTLLWILIGEVWAFSSWLFEIETWSITKQTIAHCLCSYLGMTPLAILCGWFPLNVRWFGFYTLVYTGAYIGLWLIEMALARIKVIQLNQQLTNQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT74</accession>
    <name>F9UT74_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, subgroup 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102061.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3158"/>
    <dbReference type="EnsemblBacteria" id="CCC80192">
        <property type="protein sequence ID" value="CCC80192"/>
        <property type="gene ID" value="lp_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3158"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2640"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_6_0_9"/>
    <dbReference type="OMA" id="PETYLNT"/>
    <dbReference type="PhylomeDB" id="F9UT74"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2682-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="200" mass="22102" checksum="296C69EEF66A0EF2" modified="2011-10-19" version="1">MKKGLIIGATGSIGSAARKILLAKTDVQLTLYSRRADRLKLIVDRETAVAGSVTDDDQLDQAIKGQDFVFVALNGDMDSFAAHIISAMERNGIQRLIFITTMGIYQEIPAWLGDSPEPYHNPILKSFRQAADRIEQSDLNYTIIRPGWYNNGPINYEITQKGESFGGHDVSRDSIADYVMKLITEPALDNRASVGINTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD7</accession>
    <name>F9UTD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643461.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890769.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3237"/>
    <dbReference type="DNASU" id="1061445"/>
    <dbReference type="EnsemblBacteria" id="CCC80255">
        <property type="protein sequence ID" value="CCC80255"/>
        <property type="gene ID" value="lp_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3237"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2703"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_2_9"/>
    <dbReference type="OMA" id="MIAYNGA"/>
    <dbReference type="PhylomeDB" id="F9UTD7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2743-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="29352" checksum="46CC0620A792A5A2" modified="2011-10-19" version="1">MIKLIVSDIDGTLVDSQGQLLPATITGVQAAVARGAQMVLASARSPKGMFGIAQQLGINSTMIAYNGALTATTDVNDRLTVFEEQAVDPKLAQAVQTVVAHDWPAASISIYSNNNWLVATNGPWEQQEATGIGYAPHVTDLGTWLQRMPTPVHKMMIMADPDIIQAIEQRLSRNEFSGLAVYRSKETYLEIVAAGVTKAAALMKLLQDDQVTPAETLAFGDNFNDVAMLQTAGIGVAMANAPQPVKEAANIVTTDNNHNGIQLTLAQYFADVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD8</accession>
    <name>F9UTD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102089.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890770.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3238"/>
    <dbReference type="EnsemblBacteria" id="CCC80256">
        <property type="protein sequence ID" value="CCC80256"/>
        <property type="gene ID" value="lp_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3238"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2704"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119478_0_0_9"/>
    <dbReference type="OMA" id="FRAYIKV"/>
    <dbReference type="PhylomeDB" id="F9UTD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2744-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="16946" checksum="48FB5167C765A71B" modified="2011-10-19" version="1">MTNGTRADLRELFHKGQLTIGISELSRMTGVSPRQLRYWQKKGYIIPKNEDEPGQARVYTMKMVIKAAAMSNLLQTGYTLKAAAAQVDERMRPAQTIYHLLADRYQGYEVADNGQILVDLGPFDPQPDQELFVKLVGDKVKFELKDKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH2</accession>
    <name>F9UTH2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methonine synthase (Cobalamine-independent),C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102105.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890804.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3283"/>
    <dbReference type="EnsemblBacteria" id="CCC80290">
        <property type="protein sequence ID" value="CCC80290"/>
        <property type="gene ID" value="lp_3283"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3283"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2740"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_9"/>
    <dbReference type="OMA" id="HPMLDHF"/>
    <dbReference type="PhylomeDB" id="F9UTH2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2778-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="372" mass="42020" checksum="C0EFE0411D0ED034" modified="2011-10-19" version="1">MTTTTLTVPFRFDVVGSLLRPASLKKAHEQLAAGTITRDQELEIQHTEIKRVVAEQVKLGLKAVTDGEFSRSWWHLDFLWGLTGVGKYDYHQSYKFKGDHTRTDNAELIGKVAYNPDHPFFAAFEYLQSIVPAGVLAKQTIPSPTMLFRDNRSDNWTKFYDSWDAYLNDLAQAYHDTIQHFYDLGCRYIQLDDTTWAFLISKLNDPEADHAAYTKWATDAVTVINAALADLPSDLTVTTHICRGNFKSTYLFSGSYDVVAPYLGQLNYDGLFLEYDNERAGGFEALDQIWNHDDHKRIVLGLVTSKFPELEKTTVIKERVQAATTKVPLRNLALSTQCGFASTEEGNQLTEAQQWAKLALVIGTAKEVWSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH5</accession>
    <name>F9UTH5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, hemolysin III family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890807.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3286"/>
    <dbReference type="EnsemblBacteria" id="CCC80293">
        <property type="protein sequence ID" value="CCC80293"/>
        <property type="gene ID" value="lp_3286"/>
    </dbReference>
    <dbReference type="GeneID" id="57026556"/>
    <dbReference type="GeneID" id="66450821"/>
    <dbReference type="KEGG" id="lpl:lp_3286"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2743"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTH5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2781-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="23988" checksum="86CD6AAA634F99FD" modified="2011-10-19" version="1">MAQSARQYQITNEVLNSVTHGIGIILSIVAFVFLMLKAYADGQPLEWAAFIIYGCSLFVLYTCSTLFHGLYFTRAREVFRIFDHSGVYVLIAGTYTPYSLLAIKGWLGWTILLTIWILAIAGITVNAVWPGRLKKVETVIYVLMGWMCLAGGRQLWDHLGVTGFWLLVAGGVAFTLGALLYSFPRIKYLHVIWHLFVMVGTTLMFFSIYFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK7</accession>
    <name>F9UTK7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase, C-terminal</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">lp_3332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3332"/>
    <dbReference type="EnsemblBacteria" id="CCC80325">
        <property type="protein sequence ID" value="CCC80325"/>
        <property type="gene ID" value="lp_3332"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3332"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184837_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8503" checksum="EF33E49650156D42" modified="2011-10-19" version="1">MKASLHFNRFSVRGFDKVTKEAGIVILALNIMKLVTVGTNFKNQRRKQMGRETKIRFLVPFAYTEASYVTASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM4</accession>
    <name>F9UTM4_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643507.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890856.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3351"/>
    <dbReference type="EnsemblBacteria" id="CCC80342">
        <property type="protein sequence ID" value="CCC80342"/>
        <property type="gene ID" value="lp_3351"/>
    </dbReference>
    <dbReference type="GeneID" id="57026605"/>
    <dbReference type="KEGG" id="lpl:lp_3351"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2794"/>
    <dbReference type="eggNOG" id="ENOG50319NA">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110620_2_0_9"/>
    <dbReference type="OMA" id="ANELWQV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2831-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="168" mass="18630" checksum="E960753C641EA06F" modified="2011-10-19" version="1">MTEGFRPSHPKIEIDDDPGIRAQIEALTGELSQQQLAKWALIIAKKALQYVDNQQKYDRQLRLAIDANELWQVNLVSGYQVRQALARLTKLSATTTSSIGAAALDCVRWAVASADADENALRASDQAIKLVNLTQPNDMVAVTAERQWQYDQLAGLAANIQQGLRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN3</accession>
    <name>F9UTN3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100948.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888317.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0276"/>
    <dbReference type="EnsemblBacteria" id="CCC77803">
        <property type="protein sequence ID" value="CCC77803"/>
        <property type="gene ID" value="lp_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0276"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.230"/>
    <dbReference type="eggNOG" id="ENOG5030GIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293033_0_0_9"/>
    <dbReference type="OMA" id="MVYSPRQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-225-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="23683" checksum="090EC36F60691531" modified="2011-10-19" version="1">MSQLTKAITRQLQRQYAEPVLKDLNGNWYTGADVLEDLALCETSLQQQNVHAGQAILLSPAQVVTIPGLLLASWQLGLTVTLTPPSRQLPELAPQIYAAMVYSPSQTNQLATKLDPHEISVLTLILNTAPNFAYLVHDHAQPLTRRSQPDLILPASQLQFTQPQLLKMAEHGQTSAHVHDLYNLETGLLPCLTDLITATPFTIIPTKQDWPSKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ9</accession>
    <name>F9UTQ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine cleavage system, H protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcsH1</name>
        <name evidence="1" type="ordered locus">lp_0305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888343.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0305"/>
    <dbReference type="EnsemblBacteria" id="CCC77829">
        <property type="protein sequence ID" value="CCC77829"/>
        <property type="gene ID" value="lp_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0305"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.258"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_3_1_9"/>
    <dbReference type="PhylomeDB" id="F9UTQ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-251-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="14004" checksum="DF218352AB941FD4" modified="2011-10-19" version="1">MAKQESAWKQMIHFYRHDYEEQHAPMLYGDVWLKTKSHDRLLLGLSDQGQHNLGVVHQLDLPTKGQHLVAGDPLVTITDDQGAHLVSTPFSGTVQKLNKDLQAAPQSLINNKQTDNWLVQLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTT2</accession>
    <name>F9UTT2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fba</name>
        <name evidence="5" type="ordered locus">lp_0330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641904.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888366.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0330"/>
    <dbReference type="EnsemblBacteria" id="CCC77852">
        <property type="protein sequence ID" value="CCC77852"/>
        <property type="gene ID" value="lp_0330"/>
    </dbReference>
    <dbReference type="GeneID" id="57027142"/>
    <dbReference type="GeneID" id="66448422"/>
    <dbReference type="KEGG" id="lpl:lp_0330"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.280"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_9"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="PhylomeDB" id="F9UTT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-274-MON"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="3">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="3">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="287" mass="30921" checksum="32ADF80F49D26454" modified="2011-10-19" version="1">MSFVNAVDMTQDAYKNHYAIGAFNTNNLEWTRCILKGAQDTNTPVIIQVSMGAAKYMGGYKLVMDLVADEMESMNITVPVVMHLDHGNYEAAKECIEVGYSSVMFDGHDLPFAENLEKTKEIVKLAHAKGISVEAEVGSIGGEEDGIIGEGELADVEEAKTLAATGIDILAAGIGNIHGKYPENWTGLHFDRLQEISEAVKMPLVLHGGSGIPKDQIVKAVELGISKVNVNTENQVAFANATRAYIESGADQIGKGYDPRKLLAPGKKAIVDVVTSRIGWFKTPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY1</accession>
    <name>F9UTY1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77901">
        <property type="protein sequence ID" value="CCC77901"/>
        <property type="gene ID" value="lp_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0387"/>
    <dbReference type="HOGENOM" id="CLU_187595_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTY1"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="63" mass="6872" checksum="87D20CD03AC1EDB7" modified="2011-10-19" version="1">MRKRTQTNLVDVIIPVAYFAVRAILAVMIQTTTHGLVSSLVGSLLFSLAYYGLSAWGKCLANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTY6</accession>
    <name>F9UTY6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100993.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888420.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0395"/>
    <dbReference type="EnsemblBacteria" id="CCC77906">
        <property type="protein sequence ID" value="CCC77906"/>
        <property type="gene ID" value="lp_0395"/>
    </dbReference>
    <dbReference type="GeneID" id="66448480"/>
    <dbReference type="KEGG" id="lpl:lp_0395"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.328"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_5_0_9"/>
    <dbReference type="OMA" id="DSIDVIM"/>
    <dbReference type="PhylomeDB" id="F9UTY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-329-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="28987" checksum="39AEC6A78C711F4D" modified="2011-10-19" version="1">MIKLMATDMDGSFLRDDMTYDEAQFALLYQQLQLRGVRFVIASGNQYFQLKSFFKDYPEMIYLAENGAYIRDADHVYALNAFQPDAIQTILNKIQTIPDLKLLVCGAKSAYTLTTTNPEHVAQMRHYYHHLAVVESYDQLDDDIMKFAITCPPERTTAIVTQLRELLTGIAEPTSSGHGDIDIIQPGMNKAAGLAQLGQVLGIDLADMAAFGDGGNDLEMLREVGCGVAMANAQPAVTAVANATTGTNQEQGVLQWIKNWLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU22</accession>
    <name>F9UU22_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts7C</name>
        <name evidence="11" type="ordered locus">lp_0436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641998.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888456.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0436"/>
    <dbReference type="EnsemblBacteria" id="CCC77942">
        <property type="protein sequence ID" value="CCC77942"/>
        <property type="gene ID" value="lp_0436"/>
    </dbReference>
    <dbReference type="GeneID" id="57024236"/>
    <dbReference type="GeneID" id="66448516"/>
    <dbReference type="KEGG" id="lpl:lp_0436"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.356"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_2_9"/>
    <dbReference type="OMA" id="QLFWVIG"/>
    <dbReference type="PhylomeDB" id="F9UU22"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-363-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="453" mass="49169" checksum="E10DAA013E5AB83A" modified="2011-10-19" version="1">MNSFIEWLNKHLVPVAAKIGAVRWLIALRDAFIAIMPAMMAGSIATVLNALVRDIPTKFGWMGIVNSMQWLIGINAMVWTGTLAILGLIFSFTFGYQLAIQYKVEPVTGGIVTLGTFIMSLPQNFTGTLTSTLSKGATKILTDSGMAVAGKKVTAWGYFNFNTYFGSYGFFTVMILGAIASAVYIALMKKHITIKMPDSVPPAVANAFTGVIPAAAAFYVVGIINWIFSKFNTTVIEWIAKIIQEPLLNMSQGYGAVLLMTLLVQVFWFFGIHGSNVLAPILDGIWLTAQLANVNAYQAGKALPYVWTRNCFDLYAWIGGAGSTLLLLVAILVFSKRDDQRSVAKLAIGPGFFNINEPVMFGMPIVLDPIYFIPFVLAPVVTVSIAYAALSAGWVAPITNNIVWSMPPIMNALVATMDWRSVVLQLFNAAVAFAIYVPFVKAANKIKPAAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU54</accession>
    <name>F9UU54_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug transport protein, major facilitator superfamily (MFS), EmrB/QacA subfamily, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lmrB-C</name>
        <name evidence="3" type="ordered locus">lp_3369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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    </comment>
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    <dbReference type="EnsemblBacteria" id="CCC80356">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    <dbReference type="RefSeq" id="YP_004890905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="STRING" id="220668.lp_3410"/>
    <dbReference type="EnsemblBacteria" id="CCC80391">
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        <property type="gene ID" value="lp_3410"/>
    </dbReference>
    <dbReference type="GeneID" id="57026637"/>
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            <dbReference type="EMBL" id="CCC80391.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="107" mass="11791" checksum="B97433FA24940EFB" modified="2011-10-19" version="1">MTQNRVINALSYLSILFLPVLFPLIVWLLTSTNPEAHRVAGRAFWLHLLPTILGITLLVILGVSGIYMDSIVNSGWLAVVLLAVFGLVAVASYLWSIIRGIQYLIAD</sequence>
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    <accession>F9UUA1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80403.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_004890917.1">
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        <source>
            <dbReference type="EMBL" id="CCC80403.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    <sequence length="114" mass="12985" checksum="EFD6159204BB48DD" modified="2011-10-19" version="1">MRIMTTVTALETQAGQVLDQSYAQFKQAQLALSKEQIFANAAQIFTVGEIAAATRQYLFDEEIAQQVIKLQDQVLPTMYQQGQSGEFLKLNFTGNDIRWLLGLPRTHHRQRISK</sequence>
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    <accession>F9UUA7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102160.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890923.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3429"/>
    <dbReference type="EnsemblBacteria" id="CCC80409">
        <property type="protein sequence ID" value="CCC80409"/>
        <property type="gene ID" value="lp_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3429"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2857"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119963_0_0_9"/>
    <dbReference type="OMA" id="GEILRIC"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2897-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="192" mass="21908" checksum="BE535F9D2D4C8B47" modified="2011-10-19" version="1">MTKLIMNNQLHIDQRTHQTHRKLITALQANFKAQKIFNELTVKQLCLDAHVGRATFYRHHQDIEDIIVIEYLIALQQLGQALNDLTTTSYATIAGAIVTTLRAHLDLPLLVSWAQCRDRVIPLEVGFAQQLLTSLAIHPKQRHFMATYLGNCLHQLAWQLATTQPTLSRIETYRLFIQLIPNVLQAPTIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB7</accession>
    <name>F9UUB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding ferritin-like protein, DPS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dps2</name>
        <name evidence="3" type="ordered locus">lp_3441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645583.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUB7"/>
    <dbReference type="STRING" id="220668.lp_3441"/>
    <dbReference type="EnsemblBacteria" id="CCC80419">
        <property type="protein sequence ID" value="CCC80419"/>
        <property type="gene ID" value="lp_3441"/>
    </dbReference>
    <dbReference type="GeneID" id="57026665"/>
    <dbReference type="KEGG" id="lpl:lp_3441"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2867"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_3_0_9"/>
    <dbReference type="OMA" id="HSLKINQ"/>
    <dbReference type="PhylomeDB" id="F9UUB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2907-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="20859" checksum="2069BB18EA8D20CB" modified="2011-10-19" version="1">MSELTIDEQYAAELKQSDIDHHVPTAGAMTNHILSNLMVAYVKLTQVKWYVKGPQSLALRTAYQRLLDQNVRQFAELGELLLDENQKPSSTTAELTKYSMLEENGAFKYQSVDELVAATIKDFDTENLFVDRAIKLAEKENRPALAAWLVAYRGSNNRNIRELQAYLGNDARTGLDEEDEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUE0</accession>
    <name>F9UUE0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ram2</name>
        <name evidence="2" type="ordered locus">lp_3473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102178.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UUE0"/>
    <dbReference type="STRING" id="220668.lp_3473"/>
    <dbReference type="EnsemblBacteria" id="CCC80442">
        <property type="protein sequence ID" value="CCC80442"/>
        <property type="gene ID" value="lp_3473"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3473"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2890"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039489_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2930-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="195"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="525" mass="59670" checksum="FF608D4FBBBFD7F5" modified="2011-10-19" version="1">MAFTFQINNDVQFQHNQALLDKSASYRPILKETKVKAASIVALERDTQYLEGWGVKQIAPIERLSSYELKRDDQIIIDFGDHQVGQFSININAVGSPMDAPLCFKIKFAEMPAELARKSEDYDGWLSKSWIQEETVHLDVLPTTLTLPRRYSFRYAEITVVDTSPKWRAVFSNPVVTATSAVDTATVHQPELADVQLQRIYEVGLKTLADCMQDVFEDGPKRDRRLWIGDLRLQALANYATFKDTDLVKRCLYLFGAMPTTAGRIPANVFTKPTAVPDDTFLFDYSLFFISILADYEAFSSDKTVLNDLYRVAKKQMDLALEQVTSEGKLKLTEENPVFIDWSNDFDKETAGQAIIIYTLKQFITLAELVNDTSLETYTAILRKLNQYAKTQLFDSQSGLFVSGDQREVNVASQVWMTLAHVLDPEQTTVLMQTTVTKLFPITGIATPYMYHHITEALFEAGLKQEAVQLMKDYWGKMVTLGADTYWEAFDPNQPDYSPYGSPILNSYCHAWSCTPVYLINKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUI0</accession>
    <name>F9UUI0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator and PTS system, EIIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642878.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890996.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3516"/>
    <dbReference type="EnsemblBacteria" id="CCC80482">
        <property type="protein sequence ID" value="CCC80482"/>
        <property type="gene ID" value="lp_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3516"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2930"/>
    <dbReference type="eggNOG" id="ENOG50342SP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033613_1_0_9"/>
    <dbReference type="OMA" id="TTACEKQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2970-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="3">
        <location>
            <begin position="446"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="582" mass="66179" checksum="D5E3DC3ABEAD672E" modified="2011-10-19" version="1">MLNSRELRIILLLQEHDLSGEDLAALLETSRRTVVRDIARINGLLRSESIGSIESVKKYHLLVLNRANLNRLLTQSNHESVLVLLNLLVSPNITMGELIERTFMSRQSIMNCIEKINRQYAKILKIRLRPRIGISVSVNHISKIDILAALISDDHQLVEKRFKLINQSEDLARIRMIVKQQIPEKMFDYLTDSQLSAQIMACTLISKDNTVIMKSTLYKVLLKSGVPHLQSATLAVFFDAKKQLLNHMTIRQVQLAVRATRSRYTLAAFNHSFVNEIFKHLCRSAMFPTIAPASLSEQISYLKVQNPFAFDFAFDLSKKLQQCFESVQIDDEYIALYVLHAIESPTARNVRTLMYATQQSVANINKMIITQKISNIDIEMVFSKEQLESRLNYINYNLVIGNGVHPNDLQLPINFDSTFNGVISLDELEHLKSLSSESYIQKNLSSFLPKSHFYHAPTKYINVNQTLKAGLTNFAEQGLLTNDQSKALLAREAAGNQLVLNHVSLPHASTELSDAYKVFAITFDGIMKIDGNPIYLILIVLANEKRADSGQVFSYLYTRLKQLSNVQLQNVDTYETLIKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK7</accession>
    <name>F9UUK7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabitol-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643576.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891023.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3545"/>
    <dbReference type="EnsemblBacteria" id="CCC80509">
        <property type="protein sequence ID" value="CCC80509"/>
        <property type="gene ID" value="lp_3545"/>
    </dbReference>
    <dbReference type="GeneID" id="57026745"/>
    <dbReference type="KEGG" id="lpl:lp_3545"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2956"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_9"/>
    <dbReference type="OMA" id="GVFHNTP"/>
    <dbReference type="PhylomeDB" id="F9UUK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2997-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="352" mass="38206" checksum="6C99975168AB0DF5" modified="2011-10-19" version="1">MEAVVKTESGYDNMELKQIPIPEVTGDKVLLKVAYTGICGTDIHTFKGQYANAVTPLVLGHEFSGEVVEVGPDVKTLKPGDRVTSETTFATDGTCVYCQDKEYNLCPNRVGIGTKANGSMANYVLTREESAHILPDNVSYKMAAMSEPLASCVHAMYQKTPFTLHDTLLIMGPGPMGLLSLQIAKEIGAFVIVSGITKDADRLQIAKELGADIIVDTQKEDLAKVVMDATDGVGVTKVYDCSGATPAVNSALPLIRKGGTFQQVGLFAKPMNELDERSIIQHEITYRGSRSQNPYDWAIALHLESKGAINQDAMITKVFDLEHWRDAFDAMMAGKELKVMIASNPDDPDLAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>P77883</accession>
    <accession>F9URI5</accession>
    <name>PYRB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Aspartate carbamoyltransferase</fullName>
            <ecNumber>2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aspartate transcarbamylase</fullName>
            <shortName>ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrB</name>
        <name type="ordered locus">lp_2703</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101888.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77883"/>
    <dbReference type="SMR" id="P77883"/>
    <dbReference type="STRING" id="220668.lp_2703"/>
    <dbReference type="EnsemblBacteria" id="CCC79824">
        <property type="protein sequence ID" value="CCC79824"/>
        <property type="gene ID" value="lp_2703"/>
    </dbReference>
    <dbReference type="GeneID" id="57026084"/>
    <dbReference type="KEGG" id="lpl:lp_2703"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2263"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_1_9"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="PhylomeDB" id="P77883"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2315-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000113148" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="311" mass="34712" checksum="C035D9D9281A5431" modified="1997-02-01" version="1">MKTSQNLVSVEQFSNQDVMAYLKLAQAFKNGKTVQLSQPTFAMNLFFENSTRTHTSFEMAERRLGLQVIPFDPKTSSVTKGESLLDTLKTIEAIGVNLAVVRHPRDRYYQPLLDAGFDMSLINAGDGSGQHPSQSLLDMLTIYEEFGHFDGLKIAIVGDLAHSRVARSNMALLTQLGAQVYFGGPKEWYGRDFEAYGEYQTMDQLVATMDVMMLLRVQHERLSQVNNQTFDASAYHQQYGLTAERAARMPKHAIIMHPAPVNRGVELASDLVEAPQSRIFQQMTNGVYIRMAMVASVLAHQGLISATQVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD7</accession>
    <name>Q6LWD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf40</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222046.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133754.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723590"/>
    <dbReference type="EnsemblBacteria" id="CAG17871">
        <property type="protein sequence ID" value="CAG17871"/>
        <property type="gene ID" value="CAG17871"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17871"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3117"/>
    <dbReference type="eggNOG" id="ENOG5033D5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176913_1_0_9"/>
    <dbReference type="OMA" id="AHKPNKL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3171-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="92" mass="11103" checksum="0FCB53D226761EA2" modified="2004-07-05" version="1">MSNKYEKLVEQQARLKQKIEREDFKLRQSKYYENRQARKARSRRLIQKGALLEKYFQANNLSVEQTEELLKTFADYVNAHKPDKLKNDQPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF5</accession>
    <name>Q6LWF5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">traI</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="13">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222029.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133736.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723572"/>
    <dbReference type="EnsemblBacteria" id="CAG17853">
        <property type="protein sequence ID" value="CAG17853"/>
        <property type="gene ID" value="CAG17853"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17853"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3100"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_9"/>
    <dbReference type="OMA" id="VEHCRYR"/>
    <dbReference type="PhylomeDB" id="Q6LWF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3153-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG17853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="711" mass="79955" checksum="62100B5C92D665F3" modified="2004-07-05" version="1">MTTVILAEKPSQARSYVQAFQKSTKKQGYYTVSDPVLPENTLVTYGLGHLVELATPDKYDQKHQQWALSNLPIFPDKYKFEVSTSKRAQFKIVKDLLTKADTIIVATDSGREGSNIAWSIMNQAHINVKSKTIKRLWLNSLEKDAIITGFKNLGDWHKDYLAYKEAQTRQISDWLIGMNGSPLYTLLLRQNGVRGVYSIGRVQTPTLYMVYQRDQTIKNFKPEPYFELNAEILANQQKFVAKLDPYQRFKDETELMTFMQAKHVQKGSQDGLIKDVQKQAKKSASSQLFSLSSLQSAMNKRYHASASQTLAAIQSLYEAKFLSYPRTDCAYITDEEFEYLVANLTKYLGLVSKQVALTNTTPNKRYVNGKKVEEHYAIIMTKVVPTKEKLASLPKLQQQVYDLVLRTTLAMFADPYEYEETTIITQVGDANFKATGKVPTKQGWQALFDDHTADQQAAATLPIVHQGDQVQANLQTPQKETTPPVPFTEGTLITAMKTAGKTLDDEEAQAILKDVQGIGTSATRANVLEVLKKRGYLVTEKNKLHVSEAGITLCKAVELEPLLTSPEMTAKWEQALQQISTEERTPDNFLNQIKKFVAKLIADVPTQLTGSAAIKQQIDHQQQAQKAAEVFLETPQATVLNKQKFYIVKPKQGEDFTLPKKWSSKTLGKTAIKALITKGETSKLKGFKSKKGKSFDAKLKLDGHKLSFDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG5</accession>
    <name>Q6LWG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenical pump-driving ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsA</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222022.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133726.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723562"/>
    <dbReference type="EnsemblBacteria" id="CAG17843">
        <property type="protein sequence ID" value="CAG17843"/>
        <property type="gene ID" value="CAG17843"/>
    </dbReference>
    <dbReference type="GeneID" id="57295599"/>
    <dbReference type="KEGG" id="lpl:CAG17843"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3092"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021619_0_0_9"/>
    <dbReference type="OMA" id="KFVVMDT"/>
    <dbReference type="PhylomeDB" id="Q6LWG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3143-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015446">
        <property type="term" value="F:ATPase-coupled arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027541">
        <property type="entry name" value="Ars_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001327">
        <property type="entry name" value="Arsenical_pump-driving_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04291">
        <property type="entry name" value="arsen_driv_ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="482"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="576" mass="62897" checksum="C6ABDF861091147A" modified="2004-07-05" version="1">MQDYQPQNANLTHYLFFTGKGGVGKTTTASATAINLADAGNQVMLVSTDPASNLQDVFNTALTNKPQAINGVSGLFAANFDPVTAAGEYRESVVGPYRGVLPDAAVKNMEEQLSGSCTVEIAAFNEFANFLTDPAVDQRFDYIIFDTAPTGHALRMLQLPSAWNNYLDENDRGASCLGQLAGMGDKKAIYAKAVATLSNGDLTTLMLVTRPQKASLLEAARAAQELAAIGMTNQQLIINGTLKTPTDHASQAIFAQQQADLQQMPAVLKKFAQYEVPLRAYNVTGLNKLHLVLQATQPALATYPPLTNNYPNLDTIVADLIKTDKKIIFTMGKGGVGKTTVAVQITQKLVAQHKTVHLATTDPADHLDFFKTADPAVTISHIDEQQVLKDYQAEVLATARQTMKAADVDYVAEDLRSPCTQEIAVFRAFANIVAQNDSDVVVIDTAPTGHTLLLLDSTQSYAQEVKRTAGDVPQAIIDLLPRLQDPQQTEIVMVTLPETTPVYESMRLNEDLNRAQIAHTWWLVNQSMLATQTTHPCLQARAQNEVEWIEKVKDVSANHFAVEQWQPDFEQTLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWG7</accession>
    <name>Q6LWG7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of arsenical resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsR</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222020.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133724.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723560"/>
    <dbReference type="EnsemblBacteria" id="CAG17841">
        <property type="protein sequence ID" value="CAG17841"/>
        <property type="gene ID" value="CAG17841"/>
    </dbReference>
    <dbReference type="GeneID" id="57295597"/>
    <dbReference type="KEGG" id="lpl:CAG17841"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3090"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_5_9"/>
    <dbReference type="OMA" id="KSLCVCD"/>
    <dbReference type="PhylomeDB" id="Q6LWG7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3141-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG17841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="119" mass="13498" checksum="8CF5FFAF139DFB18" modified="2004-07-05" version="1">MDYQKYVQMLKAMADPNRLKIIDLLSCGSLCACDILEHFDFSQPTLSHHMKVLQNAGIVAARKEGKWQHYTLRPDFMLTFKQDTAQLLSSDDHCICHDDGCVDCEECASGKVVMTNEKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-12-04" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q88S84</accession>
    <accession>F9ULB0</accession>
    <name>ARAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-arabinose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araA</name>
        <name type="ordered locus">lp_3554</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642915.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88S84"/>
    <dbReference type="SMR" id="Q88S84"/>
    <dbReference type="STRING" id="220668.lp_3554"/>
    <dbReference type="EnsemblBacteria" id="CCC80517">
        <property type="protein sequence ID" value="CCC80517"/>
        <property type="gene ID" value="lp_3554"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3554"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2964"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_9"/>
    <dbReference type="OMA" id="REYAFIN"/>
    <dbReference type="PhylomeDB" id="Q88S84"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3005-MON"/>
    <dbReference type="BRENDA" id="5.3.1.4">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0054">Arabinose catabolism</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000312610" description="L-arabinose isomerase">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <sequence length="474" mass="53573" checksum="4093B8829B136C49" modified="2003-06-01" version="1">MLSVPDYEFWFVTGSQHLYGEEQLKSVAKDAQDIADKLNASGKLPYKVVFKDVMTTAESITNFMKEVNYNDKVAGVITWMHTFSPAKNWIRGTELLQKPLLHLATQYLNNIPYADIDFDYMNLNQSAHGDREYAYINARLQKHNKIVYGYWGDEDVQEQIARWEDVAVAYNESFKVKVARFGDTMRNVAVTEGDKVEAQIKMGWTVDYYGIGDLVEEINKVSDADVDKEYADLESRYEMVQGDNDADTYKHSVRVQLAQYLGIKRFLERGGYTAFTTNFEDLWGMEQLPGLASQLLIRDGYGFGAEGDWKTAALGRVMKIMSHNKQTAFMEDYTLDLRHGHEAILGSHMLEVDPSIASDKPRVEVHPLDIGGKDDPARLVFTGSEGEAIDVTVADFRDGFKMISYAVDANKPEAETPNLPVAKQLWTPKMGLKKGALEWMQAGGGHHTMLSFSLTEEQMEDYATMVGMTKAFLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE2</accession>
    <accession>F9UR72</accession>
    <name>HIS4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="1">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisA</name>
        <name type="ordered locus">lp_2556</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642716.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE2"/>
    <dbReference type="SMR" id="Q88UE2"/>
    <dbReference type="STRING" id="220668.lp_2556"/>
    <dbReference type="EnsemblBacteria" id="CCC79711">
        <property type="protein sequence ID" value="CCC79711"/>
        <property type="gene ID" value="lp_2556"/>
    </dbReference>
    <dbReference type="GeneID" id="57025975"/>
    <dbReference type="GeneID" id="66450262"/>
    <dbReference type="KEGG" id="lpl:lp_2556"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2147"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_2_9"/>
    <dbReference type="PhylomeDB" id="Q88UE2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2203-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142013" description="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <sequence length="239" mass="25530" checksum="A6B42AFE95CC2802" modified="2011-11-16" version="2">MIFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRPENFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEFGGERIVIGLDGTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVARDGTMQGPNLALYQELQAQVPTANLIASGGVRNLTDVQVLQASGFKDVIIGKALAEGGVTLAELAGVTEC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VE9</accession>
    <accession>F9UQ56</accession>
    <name>UVRC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">lp_2109</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640789.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889859.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VE9"/>
    <dbReference type="SMR" id="Q88VE9"/>
    <dbReference type="STRING" id="220668.lp_2109"/>
    <dbReference type="EnsemblBacteria" id="CCC79345">
        <property type="protein sequence ID" value="CCC79345"/>
        <property type="gene ID" value="lp_2109"/>
    </dbReference>
    <dbReference type="GeneID" id="57025652"/>
    <dbReference type="KEGG" id="lpl:lp_2109"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1786"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_9"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="PhylomeDB" id="Q88VE9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1806-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138308" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <sequence length="604" mass="68699" checksum="C67E6D1674324758" modified="2003-06-01" version="1">MASAHIEHKLSLLPDLPGCYLMKNLNSQIIYVGKAKNLKNRVRSYFKSSHTGKTARLVSEIADFEFIVTSTDKEAFLLEITLIQKHQPYFNIKLKKGTGYPYIKITNERDPQILIVSDVRKDGGYYFGPYPNVYAAQETVNFIQKVYPLRRCHGFQKRPCLYYHMGQCLGACFKTVPVAEYDAQIKRIKSFLNGHVETVKKQLTKRMDQAAADLEFERAAELRDQLNYIEMTVEKQKIISNDNTPRDLFNFYLDKGWLSIQVFFIRQARLMKREKRLFPVVSTAPEEMTSFILQFYNRKNNVLPREVLVPNGLDKQVLSDILGIPVRTPQRGQKKDLLDMAQKNARIVLEEKFRLLELDERKTTGAMQEITDALGIPAGHKIEAFDHSHIQGADLVSAMVVFTDGQPNKKLYRKYKLRTVDHADEAASTREVIRRRYTRLLKEHAALPDLILMDGGEIQLEAAKDVLENELGIATPVAAMVKNDHHKTADLLASAGDQHLHLDPKSQGFYLLQRIQDEVHRFAITFHRQVHTKHSLSSRLDEIPGVGPKTRNKLLRKFGSMSKIAGASLEEIQSLGIAKNVAQTVKFSLAGGGVTPKHYQKGAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VM8</accession>
    <accession>F9UPX6</accession>
    <name>DLTC1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-alanyl carrier protein 1</fullName>
            <shortName evidence="1">DCP 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-alanine--poly(phosphoribitol) ligase subunit 2-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dltC1</name>
        <name type="ordered locus">lp_2017</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; lipoteichoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DltC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640705.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889779.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VM8"/>
    <dbReference type="SMR" id="Q88VM8"/>
    <dbReference type="STRING" id="220668.lp_2017"/>
    <dbReference type="EnsemblBacteria" id="CCC79265">
        <property type="protein sequence ID" value="CCC79265"/>
        <property type="gene ID" value="lp_2017"/>
    </dbReference>
    <dbReference type="GeneID" id="57025573"/>
    <dbReference type="GeneID" id="66449800"/>
    <dbReference type="KEGG" id="lpl:lp_2017"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1704"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_19_0_9"/>
    <dbReference type="OMA" id="DEWNTPN"/>
    <dbReference type="PhylomeDB" id="Q88VM8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1727-MON"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036370">
        <property type="term" value="F:D-alanyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070395">
        <property type="term" value="P:lipoteichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00565">
        <property type="entry name" value="DltC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003230">
        <property type="entry name" value="DltC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01688">
        <property type="entry name" value="dltC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213091" description="D-alanyl carrier protein 1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00565"/>
        </source>
    </evidence>
    <sequence length="80" mass="8798" checksum="B32C0E48E1B8ED08" modified="2003-06-01" version="1">MTMDDTKATVLSILADLTGEDVSSNMDVNLFDEGILDSMGSVQLLLELQNQLGIEVPVSEFQRSEWDTPAKIVAKVENLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-10" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WD0</accession>
    <accession>F9UP73</accession>
    <name>Y1712_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Probable tautomerase lp_1712</fullName>
            <ecNumber>5.3.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1712</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.-"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638693.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889526.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WD0"/>
    <dbReference type="SMR" id="Q88WD0"/>
    <dbReference type="STRING" id="220668.lp_1712"/>
    <dbReference type="EnsemblBacteria" id="CCC79012">
        <property type="protein sequence ID" value="CCC79012"/>
        <property type="gene ID" value="lp_1712"/>
    </dbReference>
    <dbReference type="GeneID" id="49393963"/>
    <dbReference type="GeneID" id="66449576"/>
    <dbReference type="KEGG" id="lpl:lp_1712"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1446"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_5_1_9"/>
    <dbReference type="OMA" id="MPIVQVE"/>
    <dbReference type="PhylomeDB" id="Q88WD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1475-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018191">
        <property type="entry name" value="Tautomerase_Pseudo-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00013">
        <property type="entry name" value="taut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000209533" description="Probable tautomerase lp_1712">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via imino nitrogen" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="64" mass="7011" checksum="2E8969B3E18AAE76" modified="2007-01-23" version="3">MPIVHIDLIAGRSQEQLKNLVKDVTDAVSKNTGAPAEHIHVILSEMQKNRYSVGGVLKSDEEAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WV4</accession>
    <accession>F9UNP6</accession>
    <name>FPG_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="2">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="2">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="2">AP lyase MutM</shortName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mutM</name>
        <name evidence="2" type="synonym">fpg</name>
        <name type="ordered locus">lp_1509</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="2"/>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640272.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889349.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WV4"/>
    <dbReference type="SMR" id="Q88WV4"/>
    <dbReference type="STRING" id="220668.lp_1509"/>
    <dbReference type="EnsemblBacteria" id="CCC78835">
        <property type="protein sequence ID" value="CCC78835"/>
        <property type="gene ID" value="lp_1509"/>
    </dbReference>
    <dbReference type="GeneID" id="57025106"/>
    <dbReference type="KEGG" id="lpl:lp_1509"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1269"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_9"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="PhylomeDB" id="Q88WV4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1296-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000170831" description="Formamidopyrimidine-DNA glycosylase">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type; degenerate" evidence="2">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <sequence length="274" mass="30892" checksum="443C4379233F94C4" modified="2007-01-23" version="3">MPELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYLLFRFSNGLTMVSHLRMEGKYNVVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVPTGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKPLLLDQSKIAGIGNIYADETLWMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHVYGREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XP7</accession>
    <accession>F9UMU9</accession>
    <name>GATA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="1">Glu-ADT subunit A</shortName>
            <ecNumber evidence="1">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatA</name>
        <name type="ordered locus">lp_1148</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101268.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889052.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XP7"/>
    <dbReference type="SMR" id="Q88XP7"/>
    <dbReference type="STRING" id="220668.lp_1148"/>
    <dbReference type="EnsemblBacteria" id="CCC78538">
        <property type="protein sequence ID" value="CCC78538"/>
        <property type="gene ID" value="lp_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1148"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.969"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_9"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="PhylomeDB" id="Q88XP7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-980-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105169" description="Glutamyl-tRNA(Gln) amidotransferase subunit A">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <sequence length="487" mass="52089" checksum="EC50E8A68A9C0375" modified="2003-06-01" version="1">MTYFDQDLTSLHADLVAKKISATELAKATFANMNQVDPKLGAFLNLNEEQALQQAAALDQDGIDANNVFAGIPMAVKDNIVTKGLTTTAASKMLENFVPVYNATVVDKLLASNALIVGKTNMDEFAMGGSTETSAFHVTRNPWDISRVPGGSSGGSAVAVASGQVPVALGSDTGGSIRQPSSFNGIVGMKPTYGRVSRWGLIAFGSSLDQIGPMTRTVKDNAAALNMIAGNDVHDTTSSKQTVPDFTAGLTGDIKGMKIGLPKEYMGDGIDPKVREVIQQAVKQFEDLGATVEEVSLPNSRYGVAAYYIIASSEASSNLQRFDGIRYGFRADDVKNLEDVYVRSRSEGFGDEVKRRIMLGTFSLSAGYYDAYFHKAGQVRTMIINDFNKVFEDYDLIMGPVAPTPAFKLGDELSDPITMYMNDVLTIPVNLAGLPGMSVPAGFADGLPVGLQLIGKAFDESTMYRAGYAFEQATQVYKQTPKVGGAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX9</accession>
    <accession>F9UML2</accession>
    <name>RL16_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">lp_1041</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX9"/>
    <dbReference type="SMR" id="Q88XX9"/>
    <dbReference type="STRING" id="220668.lp_1041"/>
    <dbReference type="EnsemblBacteria" id="CCC78451">
        <property type="protein sequence ID" value="CCC78451"/>
        <property type="gene ID" value="lp_1041"/>
    </dbReference>
    <dbReference type="GeneID" id="57024698"/>
    <dbReference type="GeneID" id="66448954"/>
    <dbReference type="KEGG" id="lpl:lp_1041"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.878"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_9"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="PhylomeDB" id="Q88XX9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-894-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000062120" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="144" mass="16075" checksum="03C3AAA3C4EC9D59" modified="2003-06-01" version="1">MLVPKRVKYRRVHRGKMRGEAKGGKTVAFGDYGLQTLESHWISNRQIEAARVAMNRYMKRGGKVWIKIFPHKSYTEKGVGVRMGNGKGTPAGWVAPVKRNKIMFEVAGVPEEVAREALRLAGTKLPVKTKIVKREEVGGESDEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y41</accession>
    <accession>F9UMF0</accession>
    <name>AZOR2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN-dependent NADH:quinone oxidoreductase 2</fullName>
            <ecNumber evidence="1">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Azo-dye reductase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azo compound oxidoreductase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azoreductase 2</fullName>
            <ecNumber evidence="1">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">azoR2</name>
        <name type="ordered locus">lp_0955</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="1"/>
    <dbReference type="EC" id="1.7.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101225.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888903.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y41"/>
    <dbReference type="SMR" id="Q88Y41"/>
    <dbReference type="STRING" id="220668.lp_0955"/>
    <dbReference type="EnsemblBacteria" id="CCC78389">
        <property type="protein sequence ID" value="CCC78389"/>
        <property type="gene ID" value="lp_0955"/>
    </dbReference>
    <dbReference type="GeneID" id="57024630"/>
    <dbReference type="KEGG" id="lpl:lp_0955"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.812"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088964_3_1_9"/>
    <dbReference type="OMA" id="RNKYAPD"/>
    <dbReference type="PhylomeDB" id="Q88Y41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-825-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166337" description="FMN-dependent NADH:quinone oxidoreductase 2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <sequence length="209" mass="23634" checksum="C49786931C1452A7" modified="2003-06-01" version="1">MTKLLMINAHPHTTVPSASLTVAASFKTAYQQTHPHDEITTRDLYQDGVPALNDTTFEAWRKRKYGEELTSVEAELLSRHASWLAEFLAADKIVFVNPMYNHFLPAELKQYLDLTAVARKTFKYTVNGPVGLLPDKHVLHIQAAGGYYHQPDQHNQVEAGDPYLRGMMQLYGIQDYRTIFIEGLDQFPEQREQAITAAQVAAEKLAGEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Y75</accession>
    <accession>F9UMB4</accession>
    <name>COAA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Pantothenate kinase</fullName>
            <ecNumber>2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">coaA</name>
        <name type="ordered locus">lp_0913</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641152.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888867.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Y75"/>
    <dbReference type="SMR" id="Q88Y75"/>
    <dbReference type="STRING" id="220668.lp_0913"/>
    <dbReference type="EnsemblBacteria" id="CCC78353">
        <property type="protein sequence ID" value="CCC78353"/>
        <property type="gene ID" value="lp_0913"/>
    </dbReference>
    <dbReference type="GeneID" id="57024594"/>
    <dbReference type="GeneID" id="66448856"/>
    <dbReference type="KEGG" id="lpl:lp_0913"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.773"/>
    <dbReference type="eggNOG" id="COG1072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053818_1_1_9"/>
    <dbReference type="OMA" id="RKYTQVS"/>
    <dbReference type="PhylomeDB" id="Q88Y75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-789-MON"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000194433" description="Pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="36558" checksum="55A1F1B6CB1A15BF" modified="2003-06-20" version="1">MEDQMNYYRFSREQWKQFYRNNQHQVPLTAANLHEIEAFNDRISLDDVRDIYMPFAHLLQAKYEHYLSWRETESVFLHRQNRQSPFIIGVSGSVAVGKTTTARLLEILFKYLYPDRRTQLITTDGFLYPNAELKKMQLMERKGFPESYDMTRLIQFLNDVKSGKPLAKAPVYSHQTYDIVPNRFDVITHPDILIIEGINVLQLPSNQAIYISDFTDFSVYVDADADLIEDWYLERFKALMKTAFQDPTNYFYPWAIGDPKDAMAMAERVWEEVNLKNLNDYILPTRNRADLILHKVAHHVIDAVYFRKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YC0</accession>
    <accession>F9UM69</accession>
    <name>PEPX_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase</fullName>
            <ecNumber evidence="1">3.4.14.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">X-Pro dipeptidyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">X-prolyl-dipeptidyl aminopeptidase</fullName>
            <shortName evidence="1">X-PDAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepX</name>
        <name type="ordered locus">lp_0857</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.</text>
            <dbReference type="EC" id="3.4.14.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.11" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888822.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YC0"/>
    <dbReference type="SMR" id="Q88YC0"/>
    <dbReference type="STRING" id="220668.lp_0857"/>
    <dbReference type="ESTHER" id="lacpl-pepx">
        <property type="family name" value="Lactobacillus_peptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78308">
        <property type="protein sequence ID" value="CCC78308"/>
        <property type="gene ID" value="lp_0857"/>
    </dbReference>
    <dbReference type="GeneID" id="57024549"/>
    <dbReference type="KEGG" id="lpl:lp_0857"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.728"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011800_0_0_9"/>
    <dbReference type="OMA" id="LYTASPY"/>
    <dbReference type="PhylomeDB" id="Q88YC0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-744-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00698">
        <property type="entry name" value="Aminopeptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008252">
        <property type="entry name" value="Pept_S15_Xpro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015251">
        <property type="entry name" value="PepX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036313">
        <property type="entry name" value="PepX_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09168">
        <property type="entry name" value="PepX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00923">
        <property type="entry name" value="LACTOPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00940">
        <property type="entry name" value="PepX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81761">
        <property type="entry name" value="SSF81761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000220222" description="Xaa-Pro dipeptidyl-peptidase">
        <location>
            <begin position="1"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00698"/>
        </source>
    </evidence>
    <sequence length="813" mass="91548" checksum="FBA685F68C0119BB" modified="2003-06-01" version="1">MKNNQFAIVPTDSETAIAELTKIHFITPDMDALTTVPAVYQALLAKSLPEVHTASGLTHKFNNIMATSQHTLSEWLADATIVNNQVFYNVGLQLLGFLPGQDFELADPLLAMRDIHLPMVGDSAFDREALYYAWYLLLNTRGNNGQTLIESLTTRGYFVPFYQLPNDQKPLFFNGKAQAVFDTNALIRDVVYVEAPLDTDHDGQRDLLKVEILRPAETETGLKVPVLYTASPYNQGINDQAGDAQMHNVDVPLTAKEPDENTYADVEFQPTTAQLPAARTATTTTDTAEETFSREKSYTLNDYFLARGFAVVYAAGIGSIDSDGLAPTGDVDETTSTVAIIEWLTGKRQAFTNRDGNIAIKAWWCNGAVAMTGRSYLGTLATAAATTGVAGLKTIISEAAISSWYDYYRDNGLVVAPDTFQGEDTDVLAAEVFSRSLKAGDAHQIQPAFDQKLAELTADQDRASGNYNRFWDERNYLKNVDKIKADIIMVHGLNDWNVKPRNVANLWDKLQAVPVTKKLILHQGQHIYINNLQSLDFTDMMNLWLSHKLYGLDNHAETLLPNVLVQDNTQAQTWHGYDNWWQDTTDALDFKVQYKELVPADHTVDQRAAHFTDKLPDKLFDHYKHHLDSWQRDLLQEDKLNPLYDHRLLFKSWQAPEDQLLVGIPHVAGSVAVNKNFGMLSFMLIDFGAARRLTVSPQILAAKALDLGYHWREDDLKDFKLAGETPFKMITKGHLNLQNRHHPWHAEAIQPNVFYDFSVDLQPLFHHLLKGHQLGLVIYATDMKMTIRGNQDLQYSLNLNDIRLHVPMKKITD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YX4</accession>
    <accession>F9UL80</accession>
    <name>RL33_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmG</name>
        <name type="ordered locus">lp_0615</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003637768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888609.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YX4"/>
    <dbReference type="SMR" id="Q88YX4"/>
    <dbReference type="STRING" id="220668.lp_0615"/>
    <dbReference type="EnsemblBacteria" id="CCC78095">
        <property type="protein sequence ID" value="CCC78095"/>
        <property type="gene ID" value="lp_0615"/>
    </dbReference>
    <dbReference type="GeneID" id="49393016"/>
    <dbReference type="GeneID" id="57024390"/>
    <dbReference type="GeneID" id="66448657"/>
    <dbReference type="KEGG" id="lpl:lp_0615"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.515"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_1_9"/>
    <dbReference type="PhylomeDB" id="Q88YX4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-526-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170175" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <sequence length="49" mass="5657" checksum="E947144FA87BD846" modified="2003-06-01" version="1">MAQKKVALACTVCGSRNYTIDANPNRTDRLEVKKFCKYCGKHTLHRETR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z42</accession>
    <accession>F9UL00</accession>
    <name>KUP1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable potassium transport system protein kup 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kup1</name>
        <name type="ordered locus">lp_0525</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101041.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888529.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z42"/>
    <dbReference type="STRING" id="220668.lp_0525"/>
    <dbReference type="EnsemblBacteria" id="CCC78015">
        <property type="protein sequence ID" value="CCC78015"/>
        <property type="gene ID" value="lp_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0525"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.433"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_1_9"/>
    <dbReference type="OMA" id="AADQFEI"/>
    <dbReference type="PhylomeDB" id="Q88Z42"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-436-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000209027" description="Probable potassium transport system protein kup 1">
        <location>
            <begin position="1"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="660" mass="73362" checksum="9CC6AFF755FD1B8C" modified="2003-06-01" version="1">MSKQAQFNKHRVAGLLVAMGVVYGDIGTSPLYVMKAIITGQGGMQAVDEKFMLGAVSLVFWTMTLLTTVKYVLIALNADNHGEGGIFSLFALVRHRARWLVIPAMIGGAALLADGALTPAVTVTTAIEGLRDVPAYVQLFGASQNTIILITLGIITLLFMLQRFGTNTIGKLFGPIMLGWFTFLGVSGFVNLVQDWTILRALNPYYAWLLLISPANKVGILILGSVFLATTGAEALYSDLGHVGKTNIRLSWPYVKVCLLLSYFGQAAWILGPGQAIQGHVNPFFAMLPASLTMAAVIFATLAAIIASQSLISGSFTLVSEAIRLKLFPRLLTTYPGKAVGQMYLPVVNWGLWGVTSMLVIFFQTSERMEAAYGLAITLTMLMTTTLIYAFLRQKRLPLIGAGLLTGFFATIEVIFLIASAAKFWHGGYVAVGLALLIFLVMAVWYRGEQIVRQHNHPLSLRQYQDQLAKLRDDQTVDKFQTNVVFLTSRMDGDQVERKVLYSILDKWPKRADVYWFVNVTITDEPYTAEYTVDTLATDYLVTVKLYLGFRVRQDINRYLRTIVRDLMATGRLAAQKQTYSVTSGRDVGDFRFVIIEEKLENGSRLSRLDRLVIETKLMIKKYATTPAKWFGLEFSEVTLETVPILFNEIPALPITERQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZS6</accession>
    <accession>F9UT30</accession>
    <name>NAGB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB</name>
        <name type="synonym">gnp</name>
        <name type="ordered locus">lp_0226</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641817.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888275.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZS6"/>
    <dbReference type="SMR" id="Q88ZS6"/>
    <dbReference type="STRING" id="220668.lp_0226"/>
    <dbReference type="EnsemblBacteria" id="CCC77761">
        <property type="protein sequence ID" value="CCC77761"/>
        <property type="gene ID" value="lp_0226"/>
    </dbReference>
    <dbReference type="GeneID" id="57027048"/>
    <dbReference type="GeneID" id="66448338"/>
    <dbReference type="KEGG" id="lpl:lp_0226"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.188"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_1_0_9"/>
    <dbReference type="OMA" id="FNEPCSS"/>
    <dbReference type="PhylomeDB" id="Q88ZS6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-183-MON"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000160151" description="Glucosamine-6-phosphate deaminase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <sequence length="237" mass="25881" checksum="0BCD10BCF569A603" modified="2003-05-23" version="1">MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVNLDEYVGIAPDNDQSYKYFMQTHLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDLQILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARFFASENDVPKQAFSMGLASIMKSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZU5</accession>
    <accession>F9UT11</accession>
    <name>SERC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="1">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serC</name>
        <name type="ordered locus">lp_0204</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641796.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZU5"/>
    <dbReference type="SMR" id="Q88ZU5"/>
    <dbReference type="STRING" id="220668.lp_0204"/>
    <dbReference type="EnsemblBacteria" id="CCC77742">
        <property type="protein sequence ID" value="CCC77742"/>
        <property type="gene ID" value="lp_0204"/>
    </dbReference>
    <dbReference type="GeneID" id="57027029"/>
    <dbReference type="KEGG" id="lpl:lp_0204"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.168"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_9"/>
    <dbReference type="OMA" id="GYRASMY"/>
    <dbReference type="PhylomeDB" id="Q88ZU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-164-MON"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0718">Serine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000150177" description="Phosphoserine aminotransferase">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <sequence length="357" mass="38701" checksum="4DA8759B92DBD700" modified="2003-06-01" version="1">MPIYNFSAGPAVLPQPVITQIQAELPSFRDSGMSILEISHRSDLFAQVLQDAEQDLRDLMAIPDNYHVLFFQGGGTLQFTAAPLNLAPHHRIGLLDSGHWAQRAADEAKRVGTKVTILGSSAANHFNQLPTVVQPIDQSLDYIHLTTNNTIEGTMMTRLPVTGQVPLVADMSSNFLGEPYQVSDFGLIFAGAQKNLGPAGLTIVIVRDDLIGQVANLPSMLDYQLFAAKDSMFNTPPVFAIYAAGLVLKWLKAQGGLSTMTARNHAKAALLYDFLDQSQLFTNPVKTSDRSTMNVPFVTGQADLDAAVIQGAREHGLLNLKGHRLVGGMRASLYNAMPLAGVQALVDYLAAFEAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL60</accession>
    <name>F9UL60_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acetyl-CoA carboxylase, biotin carboxylase subunit</fullName>
            <ecNumber evidence="10">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accC1</name>
        <name evidence="10" type="ordered locus">lp_0590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.2" evidence="10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101068.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888589.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0590"/>
    <dbReference type="EnsemblBacteria" id="CCC78075">
        <property type="protein sequence ID" value="CCC78075"/>
        <property type="gene ID" value="lp_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0590"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.494"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_9"/>
    <dbReference type="OMA" id="TRWIESD"/>
    <dbReference type="PhylomeDB" id="F9UL60"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-506-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="1 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="120"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="440" mass="48253" checksum="3BCAFCF34F8A26A9" modified="2011-10-19" version="1">MFRKLLIANRGEIAVRIIKACQQLNIQTVAVCSTADRHAGYTQLADEVVCIGPAAASGSYLNAEAILMAAINTHADAIHPGYGFLAENADFAAMCAECGIAWIGPQTEQIKLMGDKARAKDFARQQAVPVLAGQSLQGLAWPDIKHAAAKIGFPLVLKASYGGGGKGIRVLTNVHELHQQLRAARQEAAASFLNDAMYLEQFLTTARHIEVQVLGTGTKLFILGDRDCSLQLHKQKVLEESSASILTETQRRTLYDLSRQLLAGTHYQSLGTIEYLFADGQFYFMEMNTRLQVEHGVTELTTGIDIVAEQIKQAAGVTVDFPEHVGLQPKCTAIEARLTATLPVKQTRIETLSWPADVRVDTDYHQGDRLVTMYDGLIAKLMVTGANRQQAVRNLQRALAQVTLTGPTTNLTFLQQTVARPAYIHDQYTIHSLARWEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL81</accession>
    <name>F9UL81_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">lp_0616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640939.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0616"/>
    <dbReference type="EnsemblBacteria" id="CCC78096">
        <property type="protein sequence ID" value="CCC78096"/>
        <property type="gene ID" value="lp_0616"/>
    </dbReference>
    <dbReference type="GeneID" id="57024391"/>
    <dbReference type="KEGG" id="lpl:lp_0616"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.516"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_8_1_9"/>
    <dbReference type="OMA" id="EMKRVSW"/>
    <dbReference type="PhylomeDB" id="F9UL81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-527-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="61" mass="7512" checksum="010DF915FD8B3FB0" modified="2011-10-19" version="1">MRLFKFFGQVGHEMKKVTWPTWRENRRDSWTVVSTSLFFVAFFALFDWIIQLLLQMLTSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD4</accession>
    <name>F9ULD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase (RNAP)-binding regulatory protein, arsenate reductase (ArsC) family, Spx subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spx5</name>
        <name evidence="4" type="ordered locus">lp_3579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891055.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3579"/>
    <dbReference type="EnsemblBacteria" id="CCC80541">
        <property type="protein sequence ID" value="CCC80541"/>
        <property type="gene ID" value="lp_3579"/>
    </dbReference>
    <dbReference type="GeneID" id="66451013"/>
    <dbReference type="KEGG" id="lpl:lp_3579"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2986"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_9"/>
    <dbReference type="OMA" id="DWNRIAF"/>
    <dbReference type="PhylomeDB" id="F9ULD4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3028-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="145" mass="16741" checksum="FECA621F6417737C" modified="2011-10-19" version="1">MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRILSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVGFNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULS0</accession>
    <name>F9ULS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101132.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888673.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0682"/>
    <dbReference type="EnsemblBacteria" id="CCC78159">
        <property type="protein sequence ID" value="CCC78159"/>
        <property type="gene ID" value="lp_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0682"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.574"/>
    <dbReference type="eggNOG" id="ENOG5032EER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2330232_0_0_9"/>
    <dbReference type="OMA" id="DGHDIEF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-593-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="11217" checksum="A0492EB5CD06F159" modified="2011-10-19" version="1">MHTLLGLGWDEWGSIVAIVTSICVLANWILNKTVRIPLNDLGKRLSRFTDESLKVRQQNADTMNAIENRVIKVEGRLDGHDIEFKHLYEKEAKGNEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULU2</accession>
    <name>F9ULU2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">lp_0707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643942.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888695.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0707"/>
    <dbReference type="EnsemblBacteria" id="CCC78181">
        <property type="protein sequence ID" value="CCC78181"/>
        <property type="gene ID" value="lp_0707"/>
    </dbReference>
    <dbReference type="GeneID" id="66448685"/>
    <dbReference type="KEGG" id="lpl:lp_0707"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.594"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_1_0_9"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="PhylomeDB" id="F9ULU2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-616-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="32881" checksum="BF19AD76909A3A3B" modified="2011-10-19" version="1">METQQSFADHAGIGTLYLVPTPIGNLQDMTYRAVATLKTVDLIAAEDTRNTQKLLNHFEITTKQISFHEHNTQERIPQLIEKLQTGVNLAQVSDAGMPSISDPGKELVAACIAANIPVVPLPGANAGLTALIASGLVPQPFYFYGFLPRKKNEQKADLAKLARRHETVVLYESPFRVAKTLTLLATVCEGTRPIVACRELTKRYEEFARGTLAEMVTWAQDHQLKGEFVLLIGGNPDKDEPETTDELAQLPVKAQVEALIAAGDKPNVAIKTIAKRRNIPRQSVYNQFHELNTNDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULV2</accession>
    <name>F9ULV2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI1</name>
        <name evidence="2" type="ordered locus">lp_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.128" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888705.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0718"/>
    <dbReference type="EnsemblBacteria" id="CCC78191">
        <property type="protein sequence ID" value="CCC78191"/>
        <property type="gene ID" value="lp_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="57024426"/>
    <dbReference type="KEGG" id="lpl:lp_0718"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.604"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_3_9"/>
    <dbReference type="PhylomeDB" id="F9ULV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-626-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="192" mass="22605" checksum="8E8CEE4E912149FC" modified="2011-10-19" version="1">MLRKFKEYFQKMTTGGNQRRQRVLAIQNHIVKVGEVNYYVSRALITDVPEMLAIERAVYAGQTPWDENAFKTELRRQSGRFYIVMRHEDRLVAFCGCVFDDRRQDAHITNIAVHPDVQGQGLGHFMMQVMMKRARKLHYQTVTLEVRYSNTIAQQLYRDLGFEKTGIKKRYYFGDHEDAIDMTYRIPVATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM78</accession>
    <name>F9UM78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641116.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888831.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0868"/>
    <dbReference type="EnsemblBacteria" id="CCC78317">
        <property type="protein sequence ID" value="CCC78317"/>
        <property type="gene ID" value="lp_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="57024557"/>
    <dbReference type="GeneID" id="66448820"/>
    <dbReference type="KEGG" id="lpl:lp_0868"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.737"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_1_9"/>
    <dbReference type="OMA" id="FEIYGTC"/>
    <dbReference type="PhylomeDB" id="F9UM78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-753-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="147" mass="16896" checksum="C9464F64996440F1" modified="2011-10-19" version="1">METPIEQAVAILRRNQFKITKQRQALLDYLVTYQDHYVAISAVDEHMRTLFAGMSHNTIYRNIKEFETLGLLELKAQANQTLVKYQCDFKHQHHHHFVCSNCGKVTELQACPLDEYEAQLPGCTITGHRIEIYGLCANCTKKQAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG3</accession>
    <name>F9UMG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, YibE/F family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101234.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888916.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0969"/>
    <dbReference type="DNASU" id="1063789"/>
    <dbReference type="EnsemblBacteria" id="CCC78402">
        <property type="protein sequence ID" value="CCC78402"/>
        <property type="gene ID" value="lp_0969"/>
    </dbReference>
    <dbReference type="GeneID" id="66448897"/>
    <dbReference type="KEGG" id="lpl:lp_0969"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.825"/>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_071016_0_0_9"/>
    <dbReference type="OMA" id="YFGQFQG"/>
    <dbReference type="PhylomeDB" id="F9UMG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-838-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="UCP031503_TM"/>
    </dbReference>
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        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP031503_mp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="254" mass="27276" checksum="72971CDD79610791" modified="2011-10-19" version="1">MNTITVLGLILLGLMTLIGGKTGATAFLSLLFNFGLLFLAVVLISWGFPAMGVSLVIGTIILAFTIFFGEDNEVAAKPAYIAALIVMVMLVLIIFPVENWIMAQGFSLEDSEDLEGMSLAIGVSFIGVAVTEAILSTLGAIAEAAIAIAAGLSEILAQHPQLPTKRLYIDGISIGKQIIGTTFNTLFFGFFGGFLALFIWFAGLHYSFGSVINNKIFVAEVLMVLFSLIGVILVVPVTTWVMTIQHRQQIKHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMJ3</accession>
    <name>F9UMJ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyadenosine kinase / deoxyguanosine kinase</fullName>
            <ecNumber evidence="6">2.7.1.113</ecNumber>
            <ecNumber evidence="6">2.7.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dgk1</name>
        <name evidence="6" type="ordered locus">lp_1011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.113" evidence="6"/>
    <dbReference type="EC" id="2.7.1.76" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888946.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1011"/>
    <dbReference type="EnsemblBacteria" id="CCC78432">
        <property type="protein sequence ID" value="CCC78432"/>
        <property type="gene ID" value="lp_1011"/>
    </dbReference>
    <dbReference type="GeneID" id="57024672"/>
    <dbReference type="KEGG" id="lpl:lp_1011"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.857"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_9"/>
    <dbReference type="OMA" id="IHVRVSF"/>
    <dbReference type="PhylomeDB" id="F9UMJ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-868-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="5">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="6"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
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            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="211" mass="24334" checksum="D64AF72EC626B3A7" modified="2011-10-19" version="1">MLVMSGTIGAGKTSLTQLVANHFGSKAFYESVDDNPILPLFYKDPKKYAFLLQIYFLNKRLDSIKSAFANDLDVLDRSIFEDSLLFHLNGDLGRATNTEVDIYDSLLDNMMQELPEASHQKSPDLLIHINISFDTMLKRIQKRGRSYEQIDQDPDLYKYYQTLNERYDDWYANYDHSPKMQIDGDQLDFVADADARKEVIRLIDEKVASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMP6</accession>
    <name>F9UMP6_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641280.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888999.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1079"/>
    <dbReference type="EnsemblBacteria" id="CCC78485">
        <property type="protein sequence ID" value="CCC78485"/>
        <property type="gene ID" value="lp_1079"/>
    </dbReference>
    <dbReference type="GeneID" id="66448987"/>
    <dbReference type="KEGG" id="lpl:lp_1079"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.914"/>
    <dbReference type="eggNOG" id="COG1307">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_1_9"/>
    <dbReference type="OMA" id="TELYFTI"/>
    <dbReference type="PhylomeDB" id="F9UMP6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-928-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="289" mass="32414" checksum="7C49AA32704C9F5E" modified="2011-10-19" version="1">MYQLLTDSTVDLPYQLLKDKHVDFVSMNVTIDDQEYADDLGHHFDLTDFYHRIGNGVMPSTAQINIGQFIEFFKPYVQAHTPILYLGFSSGLSGTFNNAQQAKTMLLQDQPDAEIYLVDSRAACCGEGLMLLDAIDKRDAGMPIAQLADWLTENRLYYHQWFTVDDLNYLYHGGRVSRTSATVGSLLQIKPVMDVDPLGHLRPVQKVRSRRRSLTTLVNNTLADLRDQTKPRIIIATSDAQEAAQTVREKILAKVPDAEILLEHIGPTITSHTGLGCVAVFSFGKTKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS1</accession>
    <name>F9UMS1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarate hydratase class II</fullName>
            <shortName evidence="3">Fumarase C</shortName>
            <ecNumber evidence="3">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fum</name>
        <name evidence="3" type="synonym">fumC</name>
        <name evidence="6" type="ordered locus">lp_1112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641313.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889024.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1112"/>
    <dbReference type="EnsemblBacteria" id="CCC78510">
        <property type="protein sequence ID" value="CCC78510"/>
        <property type="gene ID" value="lp_1112"/>
    </dbReference>
    <dbReference type="GeneID" id="57024757"/>
    <dbReference type="KEGG" id="lpl:lp_1112"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.940"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_9"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="PhylomeDB" id="F9UMS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-953-MON"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="405"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="460" mass="49497" checksum="A18DF35948A7D3ED" modified="2011-10-19" version="1">MTEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKEVEAMTAEKADLIVAAIDKLLALDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKINPDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAAEHLLAELKIKQKKYWRVVKIGRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAENIAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRAGYDELNIPANEPGSSIMPGKVNPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTVLIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDSSLMTVTALSPHIGYHDSAMIAQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS3</accession>
    <name>F9UMS3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate lyase holo-[acyl-carrier protein] synthase</fullName>
            <ecNumber evidence="2">2.7.7.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">citX</name>
        <name evidence="3" type="ordered locus">lp_1114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]</text>
            <dbReference type="Rhea" id="RHEA:16333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10157"/>
            <dbReference type="Rhea" id="RHEA-COMP:10158"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61378"/>
            <dbReference type="ChEBI" id="CHEBI:82683"/>
            <dbReference type="EC" id="2.7.7.61"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.61" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889026.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1114"/>
    <dbReference type="EnsemblBacteria" id="CCC78512">
        <property type="protein sequence ID" value="CCC78512"/>
        <property type="gene ID" value="lp_1114"/>
    </dbReference>
    <dbReference type="GeneID" id="57024759"/>
    <dbReference type="GeneID" id="66449012"/>
    <dbReference type="KEGG" id="lpl:lp_1114"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.942"/>
    <dbReference type="eggNOG" id="COG3697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104529_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMS3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-955-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050519">
        <property type="term" value="F:holo-citrate lyase synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051191">
        <property type="term" value="P:prosthetic group biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005551">
        <property type="entry name" value="CitX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03802">
        <property type="entry name" value="CitX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03124">
        <property type="entry name" value="citrate_citX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="178" mass="19913" checksum="4D764105FDDE2A15" modified="2011-10-19" version="1">MATIFTTGEPQTITAMLAARDQRVAYQQQLTATNPRATIAAIKLNIPGPIKNNAALRRLFLAGVQRFEAELSTYTVAADWNHPAGNERFLILTTDFATSKRLAVAFEEHDPLGRLYDIDILQAGSQRALSRTDLGLPKRRCLLCHREAKDCARSRRHSVAELQQKIAAMYMKEFGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMV3</accession>
    <name>F9UMV3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889056.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMV3"/>
    <dbReference type="STRING" id="220668.lp_1153"/>
    <dbReference type="EnsemblBacteria" id="CCC78542">
        <property type="protein sequence ID" value="CCC78542"/>
        <property type="gene ID" value="lp_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1153"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.973"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_43_1_9"/>
    <dbReference type="OMA" id="HYVANRN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-984-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="191" mass="21630" checksum="5F12A3698738781B" modified="2011-10-19" version="1">MVKRRTLTQAKVLATANQLIESKGINGLTIRDLALVLDVRPQSIYNYVDSLSDLLDQVGLQFVQNVADRLTETISDVDGDEALMAFAQEFRAACNQHRGLAPLLLDLNDNLRIPRSRKAIVQLYQDMFKPLQLDDSARVENTLYRSTLFGFIIQEIGGFFKMQGTELDERFTKVMQLAIDQTHLPADKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMY0</accession>
    <name>F9UMY0_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein CpsC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cps1F</name>
        <name evidence="9" type="ordered locus">lp_1182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101285.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889083.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1182"/>
    <dbReference type="EnsemblBacteria" id="CCC78569">
        <property type="protein sequence ID" value="CCC78569"/>
        <property type="gene ID" value="lp_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1182"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1000"/>
    <dbReference type="HOGENOM" id="CLU_1324994_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1012-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="207" mass="23138" checksum="CD3B4CCF4FF054B7" modified="2011-10-19" version="1">MKSNFSFLPFFKVLWYRLFWIVLFAVLGGISGYFVERQMFTPQYSVSSTVSVYHVKSKAGSNLDQLNTDVNRLGTVQSEIGDPGIYANASRLVKENKGTSIPTKYFIEHVSVSAKASSTILSVGATANTAQKAADMSNYVIQAYKNKYLKSDGRLRIEQLSKAKAMYATKSEPDYMKFIKNGALIGAILAYLVCLVLYFRKRNSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN38</accession>
    <name>F9UN38_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-2-hydroxyisocaproate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hicD2</name>
        <name evidence="7" type="ordered locus">lp_1245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644197.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889141.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UN38"/>
    <dbReference type="STRING" id="220668.lp_1245"/>
    <dbReference type="EnsemblBacteria" id="CCC78627">
        <property type="protein sequence ID" value="CCC78627"/>
        <property type="gene ID" value="lp_1245"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <ligand>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78627.1"/>
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    </evidence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </evidence>
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</entry>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="202" mass="23214" checksum="382347FA44177714" modified="2011-10-19" version="1">MSAIRDDLAKAIKNTNLVEIYSKGTNEQFSVGYVIQQDEKFVLVQAVNVDGELDGLVVFRKASLARVISDTDYLKSMATIIALAKQRGYYDVWNTERLMNKLLKKQNKTKHSLLKTLLKQAFHHDQVIQLSGRIKKHGDSYAGFIHSEHKKYIEFNYVDMFDLAKRPQIAIRYAEIDEASFHSFETFNTTAVIESFMPGDFH</sequence>
</entry>
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    <accession>F9UNN2</accession>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="165" mass="18089" checksum="31C1EA3CB94B9F7B" modified="2011-10-19" version="1">MALTFQIIGYKKSGKTLITTELVRLLTDRHLHVSVLKHDAHASTMDTPGTDTAQFSHAGAQEVILQSANGIFCHQTTVQPVPVSRLIALLPTSTDVILLEGFKHAPYPKIALLRSDDHAIDFQQFTNIQVFASLTCHPDATLVGKTAICNWFVQTYFKGAATTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1507"/>
    <dbReference type="EnsemblBacteria" id="CCC78833">
        <property type="protein sequence ID" value="CCC78833"/>
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    <dbReference type="GeneID" id="66449393"/>
    <dbReference type="KEGG" id="lpl:lp_1507"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1267"/>
    <dbReference type="eggNOG" id="COG0670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="F9UNP4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1294-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bax_inhibitor_1-related"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="26147" checksum="64DF0FDE159B0C2A" modified="2011-10-19" version="1">MNNFQNDPQPRTINTQVGLRSFLTKMYGFMTIAVLVSAFTVYLAMTTFQAQINAAFSQHPFIFLMIFIVSMFVMIGGIQVNATRNPAMSFTLLMLFAIIFGVEMSVTLSLYTGAVITGAFVAAGAVFATMAVIGTTTKRDISRIGTHLIAALIGLFVASLVNMFLQSAMISYIFSYIGVLIFAGLSMWDANRMRNMYLQYGDQVSSTGLAVTGALQLYLDFVNLFLYFVQIFGGSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645189.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889364.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78850">
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        <property type="gene ID" value="lp_1525"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="95"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
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    </evidence>
    <sequence length="160" mass="19488" checksum="FFE553EEC90105A8" modified="2011-10-19" version="1">MEKKDVMKQYVTDKYFSKGHWWTKLWQTLVAIITWICVAVPVYWTISSTLLANNPQFIHAWKYEEGKTLFYFFDRFFIIAFILIAIVVIVSTIHNNHRVKQHISKERQYNEDQLDIRKRQLNNFYTQRFGQATFRQHVKHYTVDPEQNLDVNEIHRLYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNR8</accession>
    <name>F9UNR8_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1533</name>
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    <organism evidence="2 3">
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        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889371.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1533"/>
    <dbReference type="EnsemblBacteria" id="CCC78857">
        <property type="protein sequence ID" value="CCC78857"/>
        <property type="gene ID" value="lp_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1533"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1291"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_5_2_9"/>
    <dbReference type="OMA" id="ICCDSLN"/>
    <dbReference type="PhylomeDB" id="F9UNR8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1318-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="244" mass="28033" checksum="CEF3560B6ECA1AAA" modified="2011-10-19" version="1">MIYQTFAELYDELFDPAMYQQWLDFVRREYPNQDGQLLELACGTGRLGVLLAQAGYQVTGLDLSENMLALAQRHADEAAVTLPLLQGDMLDLSEIGTFDAVTCFADSFCYLPDITTVQRAFEQVAQHLTAAGEFLFDVITPYQTDEVYPGYMYNYRDEDRAFMWTSYAGEQPHSAEHDLTFFIYNDDKQAFDEVSELHQEQTYVLADYQQALQAAGFNHVTVSADFGRQQPDDQTTRWFFKCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP39</accession>
    <name>F9UP39_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 12">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fabF</name>
        <name evidence="16" type="ordered locus">lp_1675</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644335.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889492.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1675"/>
    <dbReference type="EnsemblBacteria" id="CCC78978">
        <property type="protein sequence ID" value="CCC78978"/>
        <property type="gene ID" value="lp_1675"/>
    </dbReference>
    <dbReference type="GeneID" id="57025249"/>
    <dbReference type="GeneID" id="66449546"/>
    <dbReference type="KEGG" id="lpl:lp_1675"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1414"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_9"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="PhylomeDB" id="F9UP39"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1441-MON"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="15">
        <location>
            <begin position="5"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC78978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="410" mass="42448" checksum="EC95E460C6B0EE7E" modified="2011-10-19" version="1">MTERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEERIEKKLAKRLDLFSVYGLYSASEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIKMHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIVTACASATNAIGDAFEYLRQGKADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLETLAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYINAHGTATHANDSAEAQAISALFGQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPANIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNAVVAFKKWVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPH6</accession>
    <name>F9UPH6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase 4 subunit B</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Topoisomerase IV subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">parE</name>
        <name evidence="7" type="ordered locus">lp_1840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer composed of ParC and ParE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type II topoisomerase family. ParE type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640557.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889629.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1840"/>
    <dbReference type="EnsemblBacteria" id="CCC79115">
        <property type="protein sequence ID" value="CCC79115"/>
        <property type="gene ID" value="lp_1840"/>
    </dbReference>
    <dbReference type="GeneID" id="57025437"/>
    <dbReference type="KEGG" id="lpl:lp_1840"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1552"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_9"/>
    <dbReference type="OMA" id="KIAYAWT"/>
    <dbReference type="PhylomeDB" id="F9UPH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1578-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00939">
        <property type="entry name" value="ParE_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005740">
        <property type="entry name" value="ParE_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01058">
        <property type="entry name" value="parE_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="4">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="4">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="668" mass="74568" checksum="FEB7829CE9818BC8" modified="2011-10-19" version="1">MAKKSPKYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALAGYGKEINVIIHADNSITVVDHGRGMPVGMHASGIPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSSELTVTIVRDGYRYVEHFKDGGHPVGTLEKKGKTNKPTGTTMTFKPDASIFTTTVYNFQTLAERLRESAFLLKGVKITLTDERENQQQELVFHYEDGIKAFVSYLNEDKDTLGDIMFFDGTKEGVEVEVAAQYNDGYSENLLSFVNNVRTPDGGTHEVGFRSAWTKAFNEYARKVGLLKDKDKNLEGSDVREGLSAVISLRVPENLLQFEGQTKEKLGTPEARTIVDNIVSEQLQFFLMENGEFAQMLIRKSTKARQAREAARKARDESRNGKRRHKQERLLSGKLTPAQSKNAKKNELFLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKLADIVKNEEINTMIYTIGAGVGPEFDIKASNYDKIIIMTDADTDGAHIQILLLTFFYKYMRPMIDAGKIYIALPPLYRLQKKQNKQLRTEYAWTDEELTLKTKSFGKGYALQRYKGLGEMNAEQLWETTMDPEKRTLVRVRIDDAALAEKRVTTLMGDKVEPRRKWIESNVHFNLDEDGSLLDNEAVSSAHEQADEELAQQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI4</accession>
    <name>F9UPI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dprA</name>
        <name evidence="2" type="ordered locus">lp_1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640564.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889637.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1852"/>
    <dbReference type="EnsemblBacteria" id="CCC79123">
        <property type="protein sequence ID" value="CCC79123"/>
        <property type="gene ID" value="lp_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1852"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1560"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_3_3_9"/>
    <dbReference type="OMA" id="YSKQHTI"/>
    <dbReference type="PhylomeDB" id="F9UPI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1586-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="288" mass="31536" checksum="E68ED306B6EFC0F2" modified="2011-10-19" version="1">MQLRSLLIRLHLAHGIGYAGMVRVLQHCRQVQTVVTDPRRLGKLAHLTASQQGRFTADWQSMAFQQRLKRHAQLDILTILDDDYPPALLEAYQPPLVLFLRGQRALLTTRQLAVVGARQATSYAERVTTQLLAPLATAKLTIVSGLAKGADGFAHRTALRFNLPTIGVIGTGLDISYPRQHRDLQQQISQVGLLISEYPLGVGPEPYHFVARNRIIAGLCQTVIVVEAQAHSGSLITANIALQNNRNVLAVPGPIDAPFSVGCNQLIVAGAKPVLNSRHIIEEFLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPI8</accession>
    <name>F9UPI8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (Cobalamine-independent methonine synthase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_1856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640567.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1856"/>
    <dbReference type="EnsemblBacteria" id="CCC79127">
        <property type="protein sequence ID" value="CCC79127"/>
        <property type="gene ID" value="lp_1856"/>
    </dbReference>
    <dbReference type="GeneID" id="57025426"/>
    <dbReference type="KEGG" id="lpl:lp_1856"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1563"/>
    <dbReference type="eggNOG" id="COG0620">
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    </dbReference>
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    <dbReference type="OMA" id="YNRTRFW"/>
    <dbReference type="PhylomeDB" id="F9UPI8"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="382" mass="43216" checksum="862359F739364A0B" modified="2011-10-19" version="1">MTKTHFQLVGSLLRPASLLTYKNQIEHRDDIQYPFYEALPGYQAAETAAVKTVIATEKAHGIDVLTDGEYTKSMWHLDFIWGFSGVRRFIADEGYNFRDHDGSDFETRKDIGIEITAPLSGKHHHFIDIYQQLKSQADGNDVKLTIWSPAHAFVEFGYIDKLYGPDQIYKTVDDLHAGLLGAYKEFLTDYQAAGGKIIQFDDCLWEVFASDNQQSPFGAGNGSLQELADVAVNTNNELVDFGHQLGLKVWTHNCRGNYESRHFAEGSYNTIAKKFLHDQHYDRFFLEWDDDRAGDLSALKVLEDRPNVEVVLGLLSSKTNTLDDEDRALRLLTQASQILNKNQLYLSHQCGFASCDSGNELTAAQQWAKIDQGQKIAAKFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPJ0</accession>
    <name>F9UPJ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mrr restriction system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrr</name>
        <name evidence="6" type="ordered locus">lp_1858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101571.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889643.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1858"/>
    <dbReference type="REBASE" id="7008">
        <property type="entry name" value="LplWMrrP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79129">
        <property type="protein sequence ID" value="CCC79129"/>
        <property type="gene ID" value="lp_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1858"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1566"/>
    <dbReference type="eggNOG" id="COG1715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063822_1_0_9"/>
    <dbReference type="OMA" id="LDDYYFE"/>
    <dbReference type="PhylomeDB" id="F9UPJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1591-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="5">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="311" mass="35767" checksum="EE6F26780179448A" modified="2011-10-19" version="1">MSYKRWNVEKAIVLALRELGGTASRKIIRQTIATNEYANLKYEDVYDTKVSARTGRAYNPFLYDFNFGLKNLLTVGYISSMEWGKEISLTSTGRTAELSNYPTSEQTQLVTNYWNQKTRERVHRKLTAMQESDDKLADRDEDLVVIDDPESRQDADESQWKSDLIECLKKFNSGKFENFSRALISKMGVTIDKNRGVVRSADHGIDGFGYFKSDEFRTSRVAIQCKRYTQDQVSEPEIDKFKGVMDSFNAEYGIFVTTSHFTNRAKAKAMQGNNTVTLIDGQELADLVEKYELQITPIKTYTLNAYYYEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPQ5</accession>
    <name>F9UPQ5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889708.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1934"/>
    <dbReference type="DNASU" id="1064096"/>
    <dbReference type="EnsemblBacteria" id="CCC79194">
        <property type="protein sequence ID" value="CCC79194"/>
        <property type="gene ID" value="lp_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1934"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1631"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_4_0_9"/>
    <dbReference type="OMA" id="MFTHEMI"/>
    <dbReference type="PhylomeDB" id="F9UPQ5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1656-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="237" mass="27175" checksum="A5A4B268C3C0B56A" modified="2011-10-19" version="1">MFSYEQLEKYNETDVEIYRYVINNMDRVGYMSIRELAHELHVSTSTILRFCLKNGFEGYRDFKRALKSEQQQLTTYEPKSDVSELAHFFAKTNSSAYERKLMPALTYLRRATLVIFVGIGSSGSLARYAARCFTNAGKVAFGLEDSNYPVNTFEIHDTVVFALSESGETPELIVLVQHFQQRRCAVLSITNQSQSTLAKLSDWNFSYQLAHQRINGNYNITTQVPVVYVIETLAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPR8</accession>
    <name>F9UPR8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889721.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1948"/>
    <dbReference type="DNASU" id="1061669"/>
    <dbReference type="EnsemblBacteria" id="CCC79207">
        <property type="protein sequence ID" value="CCC79207"/>
        <property type="gene ID" value="lp_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1948"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1645"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_0_9"/>
    <dbReference type="OMA" id="DNEGISQ"/>
    <dbReference type="PhylomeDB" id="F9UPR8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1670-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="155" mass="17889" checksum="2003B8CA4CE160B2" modified="2011-10-19" version="1">MDLSTIYKKGVLTIEYFSLTKYIAGIYRESKNSINTQLQALNIRATESDLLLVVYDHPAQTQKDLAASLMLDPSLLARTVRQLEQRQLVIRFRDPADQRSLRISLTPAGEQIAIAIKKTLIDWWHDFFAAHPEVNEQVFTNQLQQVYLALQEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW6</accession>
    <name>F9UPW6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1-5M</name>
        <name evidence="2" type="ordered locus">lp_2007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2007"/>
    <dbReference type="EnsemblBacteria" id="CCC79255">
        <property type="protein sequence ID" value="CCC79255"/>
        <property type="gene ID" value="lp_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2007"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_7_3_9"/>
    <dbReference type="OMA" id="NTHKVIQ"/>
    <dbReference type="PhylomeDB" id="F9UPW6"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="119" mass="14461" checksum="36BF0CB464D5BB5C" modified="2011-10-19" version="1">MSFIAVDVQTHDIITILPGRKNADIKDFFLNHYSKRHRDRVTRVVMDFNSQYQPAIRTLFPHAKLVADNFHLVQMALRSLNQTRVQLMKRFNPQSREYRVLKYYWRLYLKDYDSLEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW8</accession>
    <name>F9UPW8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2010"/>
    <dbReference type="EnsemblBacteria" id="CCC79257">
        <property type="protein sequence ID" value="CCC79257"/>
        <property type="gene ID" value="lp_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2010"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2807085_0_0_9"/>
    <dbReference type="OMA" id="FVNDHNI"/>
    <dbReference type="PhylomeDB" id="F9UPW8"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8888" checksum="67DE898BB50047AF" modified="2011-10-19" version="1">MSCYSIRQWMLHYQRDGIDGLSEATKNQHYSQTFKQKIIRAYLNGERTIQGLTNKYGLRSTSQLRNWLIKYNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ00</accession>
    <name>F9UQ00_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">nusA</name>
        <name evidence="11" type="ordered locus">lp_2043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101642.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889803.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2043"/>
    <dbReference type="EnsemblBacteria" id="CCC79289">
        <property type="protein sequence ID" value="CCC79289"/>
        <property type="gene ID" value="lp_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2043"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1728"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_9"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="PhylomeDB" id="F9UQ00"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1750-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1" evidence="9">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="10">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="10">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="405" mass="44373" checksum="426ECE1E1D080E95" modified="2011-10-19" version="1">MSKELLGALDTLESEKGIKKEVVIEALEAALVSAYKRNYGQAQNVEVDFDQIKGNIHVYAVKEVVEDVFDSRLEVSLQDALAINRAYEIGDDIRFEVTPKNFGRIAAQTAKQVIMQRVREAERGIIYDEYSQYENEIVTGEVERQDNRFVYVSLGKVEAVMGRSDQLPGEVYRIHDKIKVYVSKVENATKGPQVFVSRTAPDLLKRLFEQEVPEIFDGIVEIVSIAREAGDRAKVAVRSNNPNVDPVGTCVGPKGQRVQTIVNELHGENMDIVEWTYDQAVFIANALNPAEVLDVIFDPENERGCTVVVPDYQLSLAIGKRGQNARLAAKLTGFKIDIKSETEASDIMDANPDDVAAAETETTEAAADAAVQSDAGEDEEPATSDAAVATPASETAVDESASDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ24</accession>
    <name>F9UQ24_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889827.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2071"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79313">
        <property type="protein sequence ID" value="CCC79313"/>
        <property type="gene ID" value="lp_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2071"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1755"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_9"/>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="PhylomeDB" id="F9UQ24"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1773-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="313" mass="35541" checksum="1BD8C83EEEBED9A4" modified="2011-10-19" version="1">MKTMSLVVPCYNEEPTIEIFYNTVEKVLADNPESFKDITTEYVFVNDGSSDDTLNVLRTLNAAHPDTVHYVSFSRNFGKEAGLLAGLEHTIGDYVAVMDVDLQDPPTLLPKMLAMLQTGDYDCIGTMRENRVGEPMIRSFLSRSFYSVVNKISKVQIIPNARDYRLMTRQMVDAILELPEYNRFSKGIFNWVGFRTTYLKFENQPRSAGETHWSIWQLFNYSMDAIVDFSDVPLKIATFTGGLLSLISIISIFVVIIRKILFDNSVSGWASTVTILLLIGGIQLFCLGIIGNYIGKIYIESKHRPHYIVQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ37</accession>
    <name>F9UQ37_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein, DUF1049 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
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    <dbReference type="HOGENOM" id="CLU_024920_1_2_9"/>
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        <location>
            <begin position="35"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02397"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="221" mass="25234" checksum="3572F1280DA0C95B" modified="2011-10-19" version="1">MHEVEINESIVADEQHCEFISKIGVPVTGWKMDLKRCFDLAVGLLGTLLSVPIVIVFAILIKLTSDGPVFYKQERVGWMGTTFDVIKLRSMYQDAEAQTGAIWAQKNDPRVTPVGRWMRKTRIDELPQFWNVLKGDMSLVGPRPERPELTEQFSERYPDFPKRLRIIPGITGYAQINGGYDITPGAKCQYDNYYIEHFSIWFDIKMLMGTVRVIISGDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQB5</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9381" checksum="DBA681218C5CE4DA" modified="2011-10-19" version="1">MADDDRLTRQQYRQQRSQPTGHDTQEQESPTAEPSASRQAYAAENNRAVEEAKTKRLARKLNWAIAGLVVGIIIVFLILFLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG0</accession>
    <name>F9UQG0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. NagD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641561.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889963.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2235"/>
    <dbReference type="EnsemblBacteria" id="CCC79449">
        <property type="protein sequence ID" value="CCC79449"/>
        <property type="gene ID" value="lp_2235"/>
    </dbReference>
    <dbReference type="GeneID" id="57025785"/>
    <dbReference type="KEGG" id="lpl:lp_2235"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1891"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_9"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="PhylomeDB" id="F9UQG0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1934-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006354">
        <property type="entry name" value="HAD-SF_hydro_IIA_hyp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01457">
        <property type="entry name" value="HAD-SF-IIA-hyp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="263" mass="28726" checksum="700B99D3C5631001" modified="2011-10-19" version="1">MGKYKGYLIDLDGTVYRGRERIPAAKRFIERLQASQTDFLLVTNNTTKSPEDVAANLANNHDIHVSPANVYTAALATADYVNDLAGDGDKTMYVIGELGLKGAMLEKGFKFDERTPRFVIVGLDYDATYHKFELATLAIKRGAKFIGTNADTNLPNERGLVPGAGSVIAMVERATQQRATYIGKPETIIMQKAVDRIGLDKHDCVMVGDNYMTDISAAINFGIDSLLVYTGVSTPELVAQQAVKPTNEINSLDEWDLDDGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQH1</accession>
    <name>F9UQH1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial type II secretion/trafficking system protein E, ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gspE</name>
        <name evidence="3" type="ordered locus">lp_2249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101696.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889974.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2249"/>
    <dbReference type="EnsemblBacteria" id="CCC79460">
        <property type="protein sequence ID" value="CCC79460"/>
        <property type="gene ID" value="lp_2249"/>
    </dbReference>
    <dbReference type="GeneID" id="57025797"/>
    <dbReference type="KEGG" id="lpl:lp_2249"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1903"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_3_0_9"/>
    <dbReference type="OMA" id="AKGAIYR"/>
    <dbReference type="PhylomeDB" id="F9UQH1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1945-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="324" mass="35989" checksum="E10E548707225DDD" modified="2011-10-19" version="1">MVIEAELNEIIQAAVNQRASDIYWLPTAEGYQVLVQAAGSLRALTQITTELAQQLMNHIKYRSNMAISDHRRPQLGAMTLTLAEQTLNLRISAVGDFLDRESLVVRLLYEGPARKLSYLVPQQRQQLSQLMRRTGLILFSGPMGSGKTSTMYDLVRQLRGQRLVMTIEDPVEIYEPQFLQLQVNAPAQMAYGDLLKVGLRHHPDVFIIGEIRDAETARIAVQAALSGHLVLSTIHARGVYGIIPRLTQLGVEAAVLEQALTAMSYQRLVPVTDGSVATIFDTVVLPHAMPKTSQMMTERWAELIDEQLAAGRLDHATANQLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL5</accession>
    <name>F9UQL5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641501.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890018.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2304"/>
    <dbReference type="EnsemblBacteria" id="CCC79504">
        <property type="protein sequence ID" value="CCC79504"/>
        <property type="gene ID" value="lp_2304"/>
    </dbReference>
    <dbReference type="GeneID" id="57025840"/>
    <dbReference type="KEGG" id="lpl:lp_2304"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1948"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047530_0_1_9"/>
    <dbReference type="PhylomeDB" id="F9UQL5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1988-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4115" evidence="3">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="290" mass="31341" checksum="57846577635BBB6F" modified="2011-10-19" version="1">MSENNEETTTIGARLKAARTAKGLTIDDLQQITKIQKRYLIAIEDEQFDKLPGDFYVRAFVKQYAETVDLDGNALLEEYRDQLPSVHTETIVENVDEVQPTRVASREQPASPASRVRNYLPTIIVTAIVVLILLFIWFMAVRTHAGSSSSTSADSSSVQVSSSKKQSSSSKASSSAKSSSKASSAKEQTIKANGSSDTAYTLTNGADKNKVVIKSTKAAWTSVTTNGTQTWQGTLKADGSHTLTLPSNATTVKFQFGNATATTVTINGKAFNFNPKNSTSQVRTITLTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQL9</accession>
    <name>F9UQL9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine/histidine ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnH2</name>
        <name evidence="4" type="ordered locus">lp_2312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890022.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2312"/>
    <dbReference type="EnsemblBacteria" id="CCC79508">
        <property type="protein sequence ID" value="CCC79508"/>
        <property type="gene ID" value="lp_2312"/>
    </dbReference>
    <dbReference type="GeneID" id="57025844"/>
    <dbReference type="KEGG" id="lpl:lp_2312"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1953"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_9"/>
    <dbReference type="OMA" id="DTPFENF"/>
    <dbReference type="PhylomeDB" id="F9UQL9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1992-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388950" evidence="2">
        <location>
            <begin position="34"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="47"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="279" mass="31333" checksum="238D4A56A4A7BEEA" modified="2011-10-19" version="1">MKKRLFALSLIVVMLLGMATTLSGCGQNVTKRADTQDTWSKIKKRGYVVVGLDDSFVPMGFREKSGKLVGYDIDLARAVFKLYGIKISFQTIDWSMNATELRNGTIDLIWNGYTKNPQREKVVAFSNTYLKNKQVLVSLKKNHINSFDDMTGKTLGVQSGSSGYESLENNPKLLKDKIAKKTPVQYDTFTNAFLDLNAGRIKGLLIDSVYASYYIKHEANSADYQETQGTFKSEDFAVGMRKGDKTMKRKINAGLKTLKANGTLDKINKKWFGNQKVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS8</accession>
    <name>F9UQS8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ordered locus">lp_2382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641430.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890081.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2382"/>
    <dbReference type="EnsemblBacteria" id="CCC79567">
        <property type="protein sequence ID" value="CCC79567"/>
        <property type="gene ID" value="lp_2382"/>
    </dbReference>
    <dbReference type="GeneID" id="57025911"/>
    <dbReference type="KEGG" id="lpl:lp_2382"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2013"/>
    <dbReference type="eggNOG" id="COG3442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064047_0_0_9"/>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="PhylomeDB" id="F9UQS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2052-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="26619" checksum="69A32B0848EF3C39" modified="2011-10-19" version="1">MTYTLHAAHLYGDLMNTYGDIGNILAMRYYAKAVDADITVDLVSLDDRFDEEKYDFALFGGGQDYEQTIVSKDLQTKKDALTAYIEAGGPLLAICGGFQMLGHYYIGAHGEKIAGIGALDHYTLSQDNNRFIGNITIENAETHQTYYGFENHNGMTFLGEGERPLGQVLQGNGNNGKDQSEGVIYKNTFGSYFHGPILARNEALAKRILKLALQRKYPEGNFDALDQLNEDLTKNVIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT2</accession>
    <name>F9UQT2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">bcaT</name>
        <name evidence="14" type="ordered locus">lp_2390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101728.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2390"/>
    <dbReference type="EnsemblBacteria" id="CCC79571">
        <property type="protein sequence ID" value="CCC79571"/>
        <property type="gene ID" value="lp_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2390"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2016"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_9"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="PhylomeDB" id="F9UQT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2056-MON"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="37902" checksum="6B5E0C628DB23AFB" modified="2011-10-19" version="1">MADVQLDWNNLGFEYRNLPYRYRAYWKDGAWYKKELTGDATLHISEGSTALHYGQQDFEGLKAYRTKDGSVQLFRPDRNAARMQTSCERLLMPQVPTDMFVDAVKQVVKANQDYVPPYGTGATLYLRPLMIGVGGNIGVHPAQEYIFTVFAMPVGSYFKGGMTPTNFTTSEYDRAAHKGTGAYKVGGNYAASLFPGQEAHANGFSDCVYLDPVEHRKIEEVGSANFFGITKDGTFVTPKSPSILPAVTKYSLLYLAEHKFGMKTEQGDVYIDDLDRFAEAGACGTAAVISPIGGLEHQGKLHVFYSETEVGPVTKKLYDELTGIQFGDREAPEGWVQKVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU6</accession>
    <name>F9UQU6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101738.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890099.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2406"/>
    <dbReference type="EnsemblBacteria" id="CCC79585">
        <property type="protein sequence ID" value="CCC79585"/>
        <property type="gene ID" value="lp_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2406"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2032"/>
    <dbReference type="HOGENOM" id="CLU_2700142_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2070-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="85" mass="9504" checksum="93F4BDDDA60CD792" modified="2011-10-19" version="1">MSIALKNAVKIVTDAVDAINKRFPIKWEDIANKPNIDVTNFYTKEEIGKILNANNQLVSPDGAAWKPTIDNNGVVSWKKVMPNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
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        <name evidence="1" type="ordered locus">lp_2411</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890104.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2411"/>
    <dbReference type="EnsemblBacteria" id="CCC79590">
        <property type="protein sequence ID" value="CCC79590"/>
        <property type="gene ID" value="lp_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2411"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2037"/>
    <dbReference type="eggNOG" id="ENOG5030A8X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127609_0_0_9"/>
    <dbReference type="OMA" id="KIMDIMQ"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2075-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024410">
        <property type="entry name" value="Phage_TAC_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12363">
        <property type="entry name" value="Phage_TAC_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024865">
        <property type="entry name" value="UCP024865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="162" mass="18396" checksum="88E7E3E49C9FFD01" modified="2011-10-19" version="1">MENLIIDGTTCTPKLNYAFANQVKKELSENGRDGFDVLVDGLLDEDPDQIVNAYYYALAYFKRSQPSRDKVVEALEDTIFADDDKTNAAYSDIIQSLHADNFLARKLTSFVKGYNKIMDIMQKKLESEKEGSDQYNQDQLGMEQLQAQLDKLKKVLQPGTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW5</accession>
    <name>F9UQW5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890118.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2425"/>
    <dbReference type="EnsemblBacteria" id="CCC79604">
        <property type="protein sequence ID" value="CCC79604"/>
        <property type="gene ID" value="lp_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2425"/>
    <dbReference type="eggNOG" id="ENOG502ZNP8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2954830_0_0_9"/>
    <dbReference type="OMA" id="VQHASTK"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2088-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="59" mass="6993" checksum="195284A5CFF6E33F" modified="2011-10-19" version="1">MPVMIHSKYGYESPEWVQADARLDKWCKNRKRRAKQHGAFRLDKNKEVQHASTKEASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQX2</accession>
    <name>F9UQX2_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Prophage P2a protein 25</fullName>
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        <name evidence="2" type="ordered locus">lp_2432</name>
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    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101764.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890125.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2432"/>
    <dbReference type="EnsemblBacteria" id="CCC79611">
        <property type="protein sequence ID" value="CCC79611"/>
        <property type="gene ID" value="lp_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2432"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2055"/>
    <dbReference type="eggNOG" id="ENOG5030BCW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212684_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2097-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="55" mass="6714" checksum="CE210F6E1CA7C5D9" modified="2011-10-19" version="1">MPKHTKKRSTIKRKHRRMKQHAEANKAKAQDSKQLAKEYEPYNIRKWAFEAFKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQZ9</accession>
    <name>F9UQZ9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P2b protein 18, major capsid protein</fullName>
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        <name evidence="3" type="ordered locus">lp_2463</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890152.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2463"/>
    <dbReference type="EnsemblBacteria" id="CCC79638">
        <property type="protein sequence ID" value="CCC79638"/>
        <property type="gene ID" value="lp_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2463"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2076"/>
    <dbReference type="eggNOG" id="COG3740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029522_1_1_9"/>
    <dbReference type="OMA" id="DTRSYEK"/>
    <dbReference type="PhylomeDB" id="F9UQZ9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2130-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01543">
        <property type="entry name" value="proheadase_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="500" mass="54598" checksum="8F4E76FBB4A25737" modified="2011-10-19" version="1">MTPNCEHKRRSQKHPKTGPAENSADPQPKDSQTSKGKTISGYAIVWNSPSKDLGGFTEVVTPKALDGVDLSNVLMLNNHDYTQVLASVKAGTLTLETDDKGLHFTAQLPNTSFANDVYEEVQSGNVDSCSFGFDSDDDTDEWTKDDGGNITRTINQVKSLFDVSVVAVPAYDDTNVQVDTRSYEKFINQEKEPDNMAKQTIIDPNGNENKTGIPAFEQYVRTHGETRDGLKTDGVSAVIPKELITPVFQLKQSNYNLAQYATVKQVSSGSGTYPIATSRQSAVLATKEELAEIADINANMFTEVPFDVKTRAGKIALSNEVVEDAEVDIVGEVKNQLQQLVDNTDNTQIMSLLTGTSFTKATATNIDDLKKVFNVTLDPALSKMWLVNQSGFNYLDTLKDSEGRYLLQPNPTAPSGFTLLGAPVVMISDKLLANNVDGTSPMIVGDLSQAVAVFRRNQVTAQWDKFDQFSQGLSVIVRNDYKVIDKTAVINVALKTTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR30</accession>
    <name>F9UR30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, ATP-binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">lp_2499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101807.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890183.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2499"/>
    <dbReference type="EnsemblBacteria" id="CCC79669">
        <property type="protein sequence ID" value="CCC79669"/>
        <property type="gene ID" value="lp_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2499"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2105"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_78_2_9"/>
    <dbReference type="OMA" id="NEIGVRM"/>
    <dbReference type="PhylomeDB" id="F9UR30"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2161-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC79669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="664" mass="72804" checksum="B7BFDC61B376C9F6" modified="2011-10-19" version="1">MSFLELHDIRKAYTLNHQENVILKGINLNFERGEFISILGESGGGKSTLMNIIGGLDHQYDGDVLLDGQSLRSMNVRQMDRYRRETIGFIFQNFNLVSYLTVLDNVMLSLKMTKTSHAQQVQQAQDLLKRVGLEQQTHQYPNELSGGQKQRVAIARALASDPDIIIADEPTGALDSENTQEVMDILYSIAAEGKLVITVTHSQEVADYGTRIVHLDDGQIHDELVIGAPFDVVDKQPTRYRTLGFRQMFRMSMQHMRRMWLRYLLIIFGSSIGISSIVVMLGLGSGIQNYMNHQITSQVNPTAVQVSKKTGKVSTAARKKATSAAAYKAAVNQEQVTAAKNAEVTTANVKQLAAIKHVKSAKLGYYTSTQASYKKTTVTASLQTDNPTILSKTIKDGSRPENGQVLIGRKLAKKMVGKKNYQQALNKKLTVKLATVNRKNQSVTVSQTLTVSGITGSDDTSVVVLPQTVKKMLTAKNVAYRPNFAIVQIDKLANVKQVEHQIKAIKGTNKKQQYNYTGIGDLIDSLNTYIRLATNVLTGVAGIALLVSAIMIIVVLYVSVSERTREIGVLRALGARKRDISHLFFAEALTIGVLAAVMGLLFGEGWQFLGNMAIYSLIKYPIVRISGAAMLGGITVSVVISLLAALAPAHMAARLDPVESLSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR39</accession>
    <name>F9UR39_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein, DUF1393 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890192.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79678">
        <property type="protein sequence ID" value="CCC79678"/>
        <property type="gene ID" value="lp_2512"/>
    </dbReference>
    <dbReference type="GeneID" id="57025943"/>
    <dbReference type="GeneID" id="66450230"/>
    <dbReference type="KEGG" id="lpl:lp_2512"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2115"/>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084705_2_1_9"/>
    <dbReference type="OMA" id="SIQVPMP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2171-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="19827" checksum="AD3302F3DB4AF681" modified="2011-10-19" version="1">MGRSEQLKKLVLAGLFAAIIFIGISVLRIPLPAIVGRPFIHFGNILTVLAVMLLGFGYGATAGAVGLGLFDILNGYAATSWLTIIEAIILAAMVNLSFKSIGYREDRIGRLYWVSLVAGLTKIVTSWCTGVIEALMVGTTLKVAMIGSFTSLLAATINAVACVIIVPLLYRILVQVGFNRQRVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD6</accession>
    <name>F9URD6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642652.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890289.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2641"/>
    <dbReference type="EnsemblBacteria" id="CCC79775">
        <property type="protein sequence ID" value="CCC79775"/>
        <property type="gene ID" value="lp_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2641"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2213"/>
    <dbReference type="eggNOG" id="ENOG5030GGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104566_0_0_9"/>
    <dbReference type="OMA" id="ANFFEEG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2266-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="149" mass="16017" checksum="FC7C4FA6EA9A8857" modified="2011-10-19" version="1">MQRNVQAFIDDVTADKVTQDSLTGTYAKLATKVKPWLAKLVAALNADQLAQVTLTAKHEPAISFRLETSVINLPLANLTEIGKVTAAEDTLPINVYMIAESDALPSGLRIDELGSVADVLADQANAEKLLTDWLTAQTDRLDQITAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL3</accession>
    <name>F9URL3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642577.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890366.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2739"/>
    <dbReference type="EnsemblBacteria" id="CCC79852">
        <property type="protein sequence ID" value="CCC79852"/>
        <property type="gene ID" value="lp_2739"/>
    </dbReference>
    <dbReference type="GeneID" id="57026112"/>
    <dbReference type="KEGG" id="lpl:lp_2739"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2292"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="FARAIMS"/>
    <dbReference type="PhylomeDB" id="F9URL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2343-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="27758" checksum="91D93A80BF9CD54A" modified="2011-10-19" version="1">MTTTPIMTVSDLHKTYGKAGSKQYEALKGINFNVQPGEFVGIMGASGSGKTTLLNMLATLDQPTSGEVTIHQQPITHLKGNQLADFRAKEIGFIFQDFNLLETMTAYENIALPLSLQNTPVKKIKPAVEKVAHQLGIEEFLSNYPNELSGGQKQRVAAARALINDPAILFGDEPTGALDSKSARELLDLFTKINQERAVSILLVTHDPFSASFCQRILFIKDGRIGQELKRGDLSRSDFYQQVLDNLGTFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URL4</accession>
    <name>F9URL4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">lp_2740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101901.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890367.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2740"/>
    <dbReference type="EnsemblBacteria" id="CCC79853">
        <property type="protein sequence ID" value="CCC79853"/>
        <property type="gene ID" value="lp_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2740"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2293"/>
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    </dbReference>
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    <dbReference type="OMA" id="DQKMYDT"/>
    <dbReference type="PhylomeDB" id="F9URL4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2344-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC3_permease_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
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            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="593" mass="66208" checksum="639B5C2A66ADF77A" modified="2011-10-19" version="1">MLTKLAMTGFKHRWRDYLVLFSGLIMSSAIFYMFEALATNQDFLKQNTSISMVGLIFQFGSVLLTIITLVYIGYANSFLLSMRKRDYGLFMLVGARKSKIGQLIWLETLLVGITATIVGILVGTALTVGVSQILINSLGLTLHHFTAWYTPAAIATLLLYVGLFLIAGLFNLLSLTKTPALKLLHSNDQPNRPQLKPARQLIEIVVGVISIAIGYWSMANLKILQLMGIGIALVTIVLGTYLLFNAIFVWLMVALKRFSFAQRGLNGFTLSQLSFRIRNYTKMLSIVAMLFALALGAITVGMGFHSQIPSMANINNAYDMGLVNASTAEKAQIAAMKPKTTATYHFKATKKVVYFQAAEFNRQPFTTIHTRNKNQLTFNTVHNNAAKLQKSEDNYQLMQLQSGVMATATPVFLSKTAYAKLAQPEQRLTVFTTNNVIEHRVALNKLAKHHFHTTSPEQFGGRYAMYLMVNGMYSGLEFMGMFLGIAFLAMLASCLMFKILSGADADQHRYKMIDKVGTTRRQLNGAINKEIAVLFILPGIVGIVHVLFGLQMFKIIMVTSPYTGIWLPFLIFAGLYLLYYLITITIYRRIVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9URQ4</accession>
    <name>F9URQ4_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Hydrolase, HAD superfamily, Cof family</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">lp_2787</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79893.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890407.1">
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        <property type="gene ID" value="lp_2787"/>
    </dbReference>
    <dbReference type="GeneID" id="57026154"/>
    <dbReference type="KEGG" id="lpl:lp_2787"/>
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    <dbReference type="PhylomeDB" id="F9URQ4"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cof"/>
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        <property type="entry name" value="HAD-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="30997" checksum="7A40B0619F75A170" modified="2011-10-19" version="1">MPKYLVFMDIDGTLLTDHQYVSERTRATIERFQKQDVLFYIATGRMYELAKIVRDKVNADVRLVTSNGAVFDGAQGRELTKLGGAAVELAYLIARRDNLPMMLFTPDMAYYTEQIPRFVARNAANFDADEVSIGYEEVKSFTQLATIEDQITNGVILSREDMSRLDSAREKLTNSKLLRLSSSNPNNIEMIPLNTDKGTAVKQIQREQHVDAAHTFVFGDGLNDVGMMAEADLSVAMGNALPQVKKVANYVTDMNYNDGLALFLEKYFAAHPLSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9URS8</accession>
    <name>F9URS8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton/sodium-glutamate/aspartate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltT</name>
        <name evidence="9" type="ordered locus">lp_2818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644750.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890431.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2818"/>
    <dbReference type="EnsemblBacteria" id="CCC79917">
        <property type="protein sequence ID" value="CCC79917"/>
        <property type="gene ID" value="lp_2818"/>
    </dbReference>
    <dbReference type="GeneID" id="57026182"/>
    <dbReference type="GeneID" id="66450457"/>
    <dbReference type="KEGG" id="lpl:lp_2818"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2358"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_9"/>
    <dbReference type="PhylomeDB" id="F9URS8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2414-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="432" mass="46288" checksum="714C29930182D076" modified="2011-10-19" version="1">MKRYRQFRLSLGWQILIGLVLGIVLGVVFYGNKTAITAMQNIGTMFISLIQMIVLPIVVACLITGIANMGDLKKLGRIGGKTIIYFEIMTTIAIALGLLMGNIFHPGDYIDIHQLHASNISQYVQTAKTVSHNGIWSTVMGIIPTNVFKSLSAGDMIPVIFFAVFFGLGTAAIGEQGKIILDFMNAVAEAMFKVTNWVMHTAPIGVCALIGVTVAEMGLKALAPLGYFIILAYITMAIFIVVVMGIVGKLFGLNIWHLLRVIRDEMVLGFSTASSEAALPRIIDKMGKYGVSEGIVSFVIPTGYTFNLDGSAIYQSLAALFLAQAYGIHLSLSQQITLLIVLMITSKGIAGVPGASFVVLLATISTIGVPVQGLAFIAGIDRLVDMGRTVVNVVGNSLAAVIIGKSEHEFDTAKSDQYLAEIRAGHARAITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9US24</accession>
    <name>F9US24_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell surface protein, LPXTG-motif cell wall anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644794.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890527.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US24"/>
    <dbReference type="STRING" id="220668.lp_2940"/>
    <dbReference type="EnsemblBacteria" id="CCC80013">
        <property type="protein sequence ID" value="CCC80013"/>
        <property type="gene ID" value="lp_2940"/>
    </dbReference>
    <dbReference type="GeneID" id="57026284"/>
    <dbReference type="KEGG" id="lpl:lp_2940"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2455"/>
    <dbReference type="eggNOG" id="ENOG50309UI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650187_0_0_9"/>
    <dbReference type="OMA" id="VRIQKRE"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2509-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394312" evidence="7">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="419" mass="44286" checksum="079DFF6BAFDB12C4" modified="2011-10-19" version="1">MSKALKIVMGITMLTGGIMAQKMTVHAAESNTRTGQAVRMNGTVSLASQVENNPAVKAAHYQVTQAVQALTMATTAVKTAMSDLQAAQTTLDAANKTLAKNQKIQTHMGVLKQAATDRHVKATKALDEQLATKKTSQTAVTTAQAAVTKSQAAVQVAQSNFDKDNSAANKVTLQTTQAKLKTVQETLTAAQANLDKTNEHVMMAEEELANAKIEVSGTSRDFQMAQRDYDIVQPQAAVNQAKAAVTAKLQRVAGTQDQVVTAQRELSQAQAGLTTVRARTLATLTAAAEKPMTEKPVGERPVVSHSTGTSTSTNQSAAPQATPAKPTLNQSSSASVPTAQRVVTTQPRQATTVLRTTTSPAMAKPVTQQTVPTTATKTATLPQTGEQTNRVLTVLGFVLLAATSLFGFSKQQRRHKTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9US28</accession>
    <name>F9US28_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890531.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2948"/>
    <dbReference type="EnsemblBacteria" id="CCC80017">
        <property type="protein sequence ID" value="CCC80017"/>
        <property type="gene ID" value="lp_2948"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2948"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2460"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032987_1_0_9"/>
    <dbReference type="OMA" id="MFKNGAN"/>
    <dbReference type="PhylomeDB" id="F9US28"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2513-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="482" mass="53324" checksum="E838CD76031456BC" modified="2011-10-19" version="1">MYKQHQFFKAADDRRGQASFCPNCGQAVAATDEFCPNCGFKLHATTDQPSPSVNTAQSTTSSTRKVRQQPQRHMPTWGWGLIAVIVVILIGGYLYGQNYYQPLNQLDRDLTALKTGKGLAKQVTSTDPSLKITNDSVKPMVTYFKNNRKSLASLASSLKSRSATNDYGIQFVKTGKDWLFFDKYQLQVTSVYATLATNHRNVALSVNGKHVATSNKATYEHKIGPYVPGSYTLTAKGTVSGHQITNKGTYYLRANGQTYDLDLRTISFTVNGTPNTTVYINGENEGTINSSGTLALNDIPWSNRMMLTGKYKAGSQTLTAKQTNVSDAEGQDVDLKFAGVMSKDTASDYLNGIFTAVSSYTSTGDLSDASDYDDRTLDDYFVNGTDNTDYKELVQMAKGYYDNDDVLDVTYEPTVLSTVPAAKQQSQITYDVKYDFTNSEDERIQVFRYTATVEKTGGHYKIVKITPAQKIRSYTKSDDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9US85</accession>
    <name>F9US85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin V acylase family protein</fullName>
            <ecNumber evidence="4">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pva1</name>
        <name evidence="4" type="ordered locus">lp_0067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100864.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888146.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US85"/>
    <dbReference type="STRING" id="220668.lp_0067"/>
    <dbReference type="MEROPS" id="C59.001"/>
    <dbReference type="EnsemblBacteria" id="CCC77632">
        <property type="protein sequence ID" value="CCC77632"/>
        <property type="gene ID" value="lp_0067"/>
    </dbReference>
    <dbReference type="GeneID" id="57026917"/>
    <dbReference type="KEGG" id="lpl:lp_0067"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.54"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_0_9"/>
    <dbReference type="OMA" id="KQVIHHG"/>
    <dbReference type="PhylomeDB" id="F9US85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-54-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="338" mass="37541" checksum="7B9DFECD443C3314" modified="2011-10-19" version="1">MCTSLTYTNSHGGHFLARTMDFNVDFETRIMFMPRHYRVTGDLGDFTTTYGFIGAGRQLNHEIFTDGVNECGVSIAALYFPNHAIYQPHSNQDKIDLAPHDFVAWVLGKITSVADLRERVKDVQLISSTAELINEIPPLHFIISDQTGETAVLEPTSGELRLLNNPVGVLTNSPNLKWQLQNLSKYGTLTNTERPLNKFINYQPGSQGPGTGALGLPGDYTSMSRFARTVFLKHYAQVPATTTDTVNLLQHILNAVTIPKGAKVAANGQATYTEYRSYMDLNHQTYALELYENPGVIQQVNLTDHLLEKQTVPLEYVLSRTPHVQLLTPDVATLPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9USE1</accession>
    <name>F9USE1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular transglycosylase, with LysM peptidoglycan binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890585.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80071">
        <property type="protein sequence ID" value="CCC80071"/>
        <property type="gene ID" value="lp_3014"/>
    </dbReference>
    <dbReference type="GeneID" id="57026341"/>
    <dbReference type="GeneID" id="66450608"/>
    <dbReference type="KEGG" id="lpl:lp_3014"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2517"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077123_1_0_9"/>
    <dbReference type="OMA" id="EQVNMAA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2565-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388121" evidence="2">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="204" mass="21336" checksum="980DF0FF62FD09B5" modified="2011-10-19" version="1">MKKLVSTIVTTSAAAAGLLFAGVLNANADSTYTVKSGDSVWAIAQKFNTTINHVETTNNIKGHYILPGQKLSIKTSSTSSDNNTSSTTSNTTSSSASTTSSSSTSNTTATTTSTSSTDSTTSSYTGSNLKSYVLSQMQSRTGVSASTWNTIITRESNWQPYVRNSSSGAYGLFQNMHISSGSVEEQVNAAVALYEAQGMAAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9USL2</accession>
    <name>F9USL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642344.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3098"/>
    <dbReference type="EnsemblBacteria" id="CCC80142">
        <property type="protein sequence ID" value="CCC80142"/>
        <property type="gene ID" value="lp_3098"/>
    </dbReference>
    <dbReference type="GeneID" id="57026408"/>
    <dbReference type="KEGG" id="lpl:lp_3098"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2588"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_9"/>
    <dbReference type="OMA" id="IAQHCIL"/>
    <dbReference type="PhylomeDB" id="F9USL2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2635-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="345" mass="37321" checksum="2F1CBB1F25C34102" modified="2011-10-19" version="1">MQKQLVVVTGGSGFIAIHIIRQLLQQGYAVRTTVRSLAKAPVIKEMLTNGGITDLSALEIVVADLAHDEHWSEAMAGATYAIDVASPTPKLNFKNKAEMIRPAVDGVRRVLTASRDAGVKRVVLTSAYGAIFAGHKNRTTPYTEADWSDLNWKAIHPYQESKTRAELAAWDFINHEGRGLELTTVNPVAVMGPVLSAKYSHSNIQIQQFLEGQVKAVPNVDSGYVDVRDVASLHLLAMTAPQANGERFLATTGETLSMLDVANVLRQAFPAFASQLPTKTIPNAAVKLAAKARPELRMVASLVGTYAETSNHKAQTLLDWHPRPAAESIIATAQSMIDLGIVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR1</accession>
    <name>F9USR1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100871.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888156.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0077"/>
    <dbReference type="DNASU" id="1061264"/>
    <dbReference type="EnsemblBacteria" id="CCC77642">
        <property type="protein sequence ID" value="CCC77642"/>
        <property type="gene ID" value="lp_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0077"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.64"/>
    <dbReference type="eggNOG" id="ENOG502ZC22">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074533_0_0_9"/>
    <dbReference type="OMA" id="QACYEDN"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-64-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014973">
        <property type="entry name" value="DUF1835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022123">
        <property type="entry name" value="DUF3658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08874">
        <property type="entry name" value="DUF1835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12395">
        <property type="entry name" value="DUF3658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="228" mass="25744" checksum="9DCC27FB8DC73C24" modified="2011-10-19" version="1">MMDVTFNSTFAVTLQHELHQPVLSLPLSLQIGDLTRLTTDDPAQLAIMSHSTDATVVKQALVTLKSQVEQGGVLRVWWSTMPDDWLGYDWLCQQLADTDAQLRQVMVPLSQVITRPGLALQTLSDLSEVLPADIAHYLQLAQDVSKDEQRAHSYEWQALVVENAPLRVNLNGHLVSVPADFYDSLLERQIQPGRPIVQIIGEMLIRYSLGLPDWWYRARLQHILSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9USX6</accession>
    <name>F9USX6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_0163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641759.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0163"/>
    <dbReference type="EnsemblBacteria" id="CCC77707">
        <property type="protein sequence ID" value="CCC77707"/>
        <property type="gene ID" value="lp_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="57026994"/>
    <dbReference type="KEGG" id="lpl:lp_0163"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.132"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535052_0_0_9"/>
    <dbReference type="OMA" id="RDVKLNQ"/>
    <dbReference type="PhylomeDB" id="F9USX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-129-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="214"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ETF_alpha" evidence="5">
        <location>
            <begin position="394"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="513" mass="53926" checksum="F30CCE726EBA3296" modified="2011-10-19" version="1">MELHLTARQTGLWQRLMALAREQLMGLAMQMESTGKVDRPTLTTLAQQLALDDPLPDDRLSQRVLSTLALAQSSAGLAMSFASSWQVEDAILTFGTPQQRQRYCAQSGVFGLAALPEQVMASSTVKATPVTAGWQLSGAVKTVLNVTQATEYLVLAQTPPNATGAFVISADQPGVTVSQPITPLGLHGLTIADVQLTDVPVTAADQIGQLGQGQRVMQRAQSLGQLFAGAITAGIWQHATDQARQLALTEQPPLTALAPAMAITAALQTSVYNAAQQADDERPFTDAAQLAAMFASQNALAPFKILMPLIGDLAYTQHSPLSALQNDVATLPLIVGTDTQLALTFATTSLNDEVADVPTTGPHTAPEHLVVADLHRVVKRLNLTRDVPVNVGSIATAKRVVALGRGAMEPAVLLQAQQLAKWIGAALAVTQPLTAMEQFSIEQQIGASAVTVAPEVLINIGVAGDDDYLAGMAGAQHVLSVNTDEQAPIFKHSQQIFVGGAAEFLAGMVAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT53</accession>
    <name>F9UT53_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-lyase / cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
            <ecNumber evidence="4">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cblB</name>
        <name evidence="4" type="ordered locus">lp_0255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="4">
        <citation type="journal article" date="2020" name="Sci. Rep." volume="10" first="14886" last="14886">
            <title>Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-lyase presumed by the crystallographic analysis.</title>
            <authorList>
                <person name="Matoba Y."/>
                <person name="Noda M."/>
                <person name="Yoshida T."/>
                <person name="Oda K."/>
                <person name="Ezumi Y."/>
                <person name="Yasutake C."/>
                <person name="Izuhara-Kihara H."/>
                <person name="Danshiitsoodol N."/>
                <person name="Kumagai T."/>
                <person name="Sugiyama M."/>
            </authorList>
            <dbReference type="PubMed" id="32913258"/>
            <dbReference type="DOI" id="10.1038/s41598-020-71756-7"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EC" id="4.4.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100941.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888298.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="6LDO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-381"/>
    </dbReference>
    <dbReference type="PDB" id="6LE4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-381"/>
    </dbReference>
    <dbReference type="SMR" id="F9UT53"/>
    <dbReference type="STRING" id="220668.lp_0255"/>
    <dbReference type="EnsemblBacteria" id="CCC77784">
        <property type="protein sequence ID" value="CCC77784"/>
        <property type="gene ID" value="lp_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0255"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.211"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_9"/>
    <dbReference type="OMA" id="LRMERAN"/>
    <dbReference type="PhylomeDB" id="F9UT53"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-206-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6LDO"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6LE4"/>
        </source>
    </evidence>
    <sequence length="381" mass="40865" checksum="1E676C0B3FF466F4" modified="2011-10-19" version="1">MKFETQLIHGGISEDATTGATSVPIYMASTFRQTKIGQNQYEYSRTGNPTRAAVEALIATLEHGSAGFAFASGSAAINTVFSLFSAGDHIIVGNDVYGGTFRLIDAVLKHFGMTFTAVDTRDLAAVEAAITPTTKAIYLETPTNPLLHITDIAAIAKLAQAHDLLSIIDNTFASPYVQKPLDLGVDIVLHSASKYLGGHSDVIGGLVVTKTPALGEKIGYLQNAIGSILAPQESWLLQRGMKTLALRMQAHLNNAAKIFTYLKSHPAVTKIYYPGDPDNPDFSIAKQQMNGFGAMISFELQPGMNPQTFVEHLQVITLAESLGALESLIEIPALMTHGAIPRTIRLQNGIKDELIRLSVGVEASDDLLADLERGFASIQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTA4</accession>
    <name>F9UTA4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein, DUF1129 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642428.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890736.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3195"/>
    <dbReference type="EnsemblBacteria" id="CCC80222">
        <property type="protein sequence ID" value="CCC80222"/>
        <property type="gene ID" value="lp_3195"/>
    </dbReference>
    <dbReference type="GeneID" id="57026484"/>
    <dbReference type="KEGG" id="lpl:lp_3195"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2670"/>
    <dbReference type="eggNOG" id="COG4858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085977_2_0_9"/>
    <dbReference type="OMA" id="AAYGIRW"/>
    <dbReference type="PhylomeDB" id="F9UTA4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2710-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009214">
        <property type="entry name" value="DUF1129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06570">
        <property type="entry name" value="DUF1129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033111">
        <property type="entry name" value="UCP033111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="26609" checksum="CB3B4F82821D25AA" modified="2011-10-19" version="1">MSESETSKTPRNAAAGAKQAQAAERPVHEATELTKRNAEYMRQMRKSLDATALSGEKKTAVLNEMTSTLLAEQGRGTTARQLYGTVQERTEEIVNPKKTPVERQKANYWVTALDNGLMLFMIFCLMYGIMGFIGTNATKNSAGANGITAILITSAIGGLGVAKLFEYLMPAKDGKKVSLWKKIAWSVLAIIVWMLVFTTMSMIQGPLNPVLPGIAYLIIAVVVFFARMWLKRRFNITTSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTB1</accession>
    <name>F9UTB1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyrimidine nucleoside transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nupC</name>
        <name evidence="9" type="ordered locus">lp_3204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642434.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890743.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3204"/>
    <dbReference type="EnsemblBacteria" id="CCC80229">
        <property type="protein sequence ID" value="CCC80229"/>
        <property type="gene ID" value="lp_3204"/>
    </dbReference>
    <dbReference type="GeneID" id="57026491"/>
    <dbReference type="KEGG" id="lpl:lp_3204"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2677"/>
    <dbReference type="eggNOG" id="COG1972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_0_0_9"/>
    <dbReference type="OMA" id="FITGQPK"/>
    <dbReference type="PhylomeDB" id="F9UTB1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2717-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="195"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="427" mass="46328" checksum="986B60DBF27C76B3" modified="2011-10-19" version="1">MVFNLVVNIIGIVVFIAIAYLFSKQKHAINWRSVGVMLVLEVLLAWFLTGSQVGVDAVKAAADGFTWLVNVSYDGIAFALASWVNVKSMDFVTSSLLPILLIVPLFDILTYIGVLPWIIKWVGRGLAYITGQPKFESFFVVEMMFLGNTEALAVSQLQLKQMKAQRNLTIAMMSMSCVTASILGAYIKMMPGQFILTAVPMNVLNAAIIAAILNPVEVKPEEDTIAKISGSAAVEETTATTETSGSEELANEQVKEAKPAREPFFSFLGDSILGAGRLILIIAANVIAFVALAKLIDKLLGLINSNLSLENIFGVVMFPFAWLLGFNPSDAFQMASYMGTKLVTNEFVVMGEVSSKVNDFAPHFRAVLTVFLTSFANFSTIGMIIGAFKGIVDREKNDLISRNVGYMLLSGILVSLLSAGVVGLFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD2</accession>
    <name>F9UTD2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system, beta-glucosides-specific EIIBCA component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts27BCA</name>
        <name evidence="16" type="ordered locus">lp_3229</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102085.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890764.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3229"/>
    <dbReference type="EnsemblBacteria" id="CCC80250">
        <property type="protein sequence ID" value="CCC80250"/>
        <property type="gene ID" value="lp_3229"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3229"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2698"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_2_1_9"/>
    <dbReference type="OMA" id="FGIHQGF"/>
    <dbReference type="PhylomeDB" id="F9UTD2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2738-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011297">
        <property type="entry name" value="PTS_IIABC_b_glu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01995">
        <property type="entry name" value="PTS-II-ABC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="111"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="504"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="649" mass="68913" checksum="2006E7D799770BB8" modified="2011-10-19" version="1">MDYKPLAKEILKNIGTKSNVRSITHCVTRVRFVLNDESQANDEVIRDLDGVLDVVKQGGQYQVVIGPSVGSVYDAIIDVANFSDNVINSSEIAAPTSDETEEKGFLNKALGLISSIFIPVLGLLSGAGMIKAILSLCTVTGLLTAKSGTYIILSALGDTLFYFFPIVVGWSAARKFGLKEIYGVTLGAFLVYPTLATAASSTAVTTIFKGTIFALKYKMTFLGIPVALQSYSSTVIPIIIIVWFASYVYKYCDKVIPDVLKMVFVPFFTLLIAGVVSLIVIGPIAMILQNILSDTVLWLVGLNKGIAGFLLGFFWSILVMFGLHWAVIPFFAIDVAHYGYDVINPLIFAGGLAVLGSAIGVAIRARDERVKSMSVAAAISAFFGINEPALYGVLIPRKKVLLTSFLAAGIGGAIAGFSGSKLYSFGASGILGLPCFINPKGIDAGFIGLCISGIVAFVFALIAALIAGAKKDAKSKPAERHLAEHSDVYAPVAGESFDLTTVHDDVFSKLVLGDGIAVKPSDGKVYAPVTGIVRVAYPTGHAVGLASDDGEEVLIHIGIDTVNLEGKHFKMHVAQGMRVKKGDLLVDFDEAAISAAGYDTTVMMVVTKSERLKSVMPTQFGPVTKDTKVLDVELQSNSVESVTAVATND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTD6</accession>
    <name>F9UTD6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,atypical SDR family, TMR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890768.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3236"/>
    <dbReference type="DNASU" id="1062207"/>
    <dbReference type="EnsemblBacteria" id="CCC80254">
        <property type="protein sequence ID" value="CCC80254"/>
        <property type="gene ID" value="lp_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3236"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2702"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_9"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="PhylomeDB" id="F9UTD6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2742-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="30461" checksum="F241EC9401751193" modified="2011-10-19" version="1">MKYAVTAATGKFGQSAVSTLNAKVGAENVLVIARNQDKAAQLFPDNPIRIGNYDDVDSMTKAFENVERVLFVSSQPGGPVDRATAHKNVVTALNAAHVKFVAYTSFPNAQAAVSALANDHRATENAIKATNIAHSFLRNNWYLENEMGFLQSGAHNQETLYWANNTAGWALEREYAEAAATVLMTDAPQEVYEFAGTPLTYAALGQALQEATGNQVKITQVSQDAYVQFLETTGLNHDTAALFASFQSPINDGALAEKSADLAHVLGRQPLEASVAIKEILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTK1</accession>
    <name>F9UTK1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642842.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890833.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80319">
        <property type="protein sequence ID" value="CCC80319"/>
        <property type="gene ID" value="lp_3322"/>
    </dbReference>
    <dbReference type="GeneID" id="57026583"/>
    <dbReference type="GeneID" id="66450847"/>
    <dbReference type="KEGG" id="lpl:lp_3322"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2770"/>
    <dbReference type="eggNOG" id="ENOG5033YZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756525_0_0_9"/>
    <dbReference type="OMA" id="HYILPDY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2810-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="142" mass="16745" checksum="FF01FA42425D3E24" modified="2011-10-19" version="1">MPKFDITLISPERAKAMLTEYKEQRKNSVPHLAHPGRYILPDYKLTRRRAAFKIVKHTFLTPHYKSYVAMDSDNGHTLWFHNFGSLTEALFWLETGLKISDTDSHSNYKEWMAKHTTEIETFKDLLREQKHKQGPKTKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL3</accession>
    <name>F9UTL3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nha2</name>
        <name evidence="8" type="ordered locus">lp_3338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643500.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890845.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3338"/>
    <dbReference type="EnsemblBacteria" id="CCC80331">
        <property type="protein sequence ID" value="CCC80331"/>
        <property type="gene ID" value="lp_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3338"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2783"/>
    <dbReference type="eggNOG" id="COG1757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033405_1_0_9"/>
    <dbReference type="OMA" id="LWENTPQ"/>
    <dbReference type="PhylomeDB" id="F9UTL3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2820-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004770">
        <property type="entry name" value="Na/H_antiport_NhaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00931">
        <property type="entry name" value="antiport_nhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="164"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="474" mass="49516" checksum="3EE1C90EAC3CE8E8" modified="2011-10-19" version="1">MNKTKAPQISTLEAVIVLLVVLGIMSAGVIGWGLSPQVPVLLAMGVVTAWAMLRGFPWSAVNAGIKEGIDKGIVPIFIFILIGAMISTWIAAGTIPTLMVIGFKIINIQWFLPSVFIVCTLVGAAVGSAFTVTSTVGIAFFGMGVTMNLNPALVAGAIISGGIFGDKLSPLSETNNLASAVVDTDLFTHIKHILWSTLPAGLISLGLFAMLGHSNTETSLAKINQTVAVLNGHFSISALALLPIVLVFICAGFKMPAIPTMLLNIFISAGLILFEQPELSLAKLTAIINTGFVSKTGNTSVDTLLSRGGIVSMMSMVALIVVTLSLGGLLVKFGLINQIMTPVAKHLNSDGKLVLAGVLTCIGVNVFVGEQFLSIILPGRAFRQAFNDGGLSGNALGRVLEDGGTVINYLVPWGVGGVFLTTTLGVPTVQYLPFVFFSLLCPVISVISGFTGVGMAHLNQRTAVKTKHVTATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTM0</accession>
    <name>F9UTM0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643505.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890852.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3346"/>
    <dbReference type="EnsemblBacteria" id="CCC80338">
        <property type="protein sequence ID" value="CCC80338"/>
        <property type="gene ID" value="lp_3346"/>
    </dbReference>
    <dbReference type="GeneID" id="57026601"/>
    <dbReference type="KEGG" id="lpl:lp_3346"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2790"/>
    <dbReference type="eggNOG" id="COG3189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_9"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="PhylomeDB" id="F9UTM0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2827-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="14359" checksum="92C75E7EAEA5C9A8" modified="2011-10-19" version="1">MQLKLERIYTKPVDTDGYRVLVDRLWPRGISKVNAQLDNWVKEIGPSTTLRKWFNHEPAKYPEFVDRYRAELDENPLTASFISQVAEQLTKTNVILLFGAKDEQHNQAVVLRDYLKDSGQLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN5</accession>
    <name>F9UTN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641854.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888319.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0279"/>
    <dbReference type="EnsemblBacteria" id="CCC77805">
        <property type="protein sequence ID" value="CCC77805"/>
        <property type="gene ID" value="lp_0279"/>
    </dbReference>
    <dbReference type="GeneID" id="57027092"/>
    <dbReference type="KEGG" id="lpl:lp_0279"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.232"/>
    <dbReference type="eggNOG" id="ENOG5030A4B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180705_0_0_9"/>
    <dbReference type="OMA" id="NGHYLYL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-227-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="83" mass="9670" checksum="D01607A0500F5D83" modified="2011-10-19" version="1">MLLDTDPKIKNITAVQLVKVTYPLVIAKTEEGEFVKVKLSDEQLQDPLFWDTLKNIRRSQLWVPLGRHFHQLLSNDWLMPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS0</accession>
    <name>F9UTS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">potC</name>
        <name evidence="7" type="ordered locus">lp_0316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641892.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888354.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0316"/>
    <dbReference type="EnsemblBacteria" id="CCC77840">
        <property type="protein sequence ID" value="CCC77840"/>
        <property type="gene ID" value="lp_0316"/>
    </dbReference>
    <dbReference type="GeneID" id="57027130"/>
    <dbReference type="KEGG" id="lpl:lp_0316"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.268"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_9"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="PhylomeDB" id="F9UTS0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-262-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="271" mass="30332" checksum="3DA647A1095E683D" modified="2011-10-19" version="1">MTLRNFKWRNLYLWLVFIVLYAPIIFLVVYSFSQGTTMNNFHGFTWQHYQDLFADSRLIAIFLDTILIALLSSLLATVIGTLGALGINSMTKPITRNTLLSLNNILMVSPDVIIGASFLIFFTALKIPLGFGSVLLSHIAFSIPIVVLMVLPKIQEMSTSLLDAAADLGANNWQLLSQVIVPYIMPGIFSGFFMALTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGINLEINALSGLMFLMALVLVIGYYFINQYSSRHRRPAVRGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTX5</accession>
    <name>F9UTX5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888409.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77895">
        <property type="protein sequence ID" value="CCC77895"/>
        <property type="gene ID" value="lp_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0379"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.321"/>
    <dbReference type="eggNOG" id="ENOG50328TX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949261_0_0_9"/>
    <dbReference type="OMA" id="ICEMTES"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-317-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="305" mass="35419" checksum="C91F83A80173FB88" modified="2011-10-19" version="1">MTKRLSEQESYFSMSEFLDSYYWASKDDSLGSLLGSVTLWSDDGELFDQAIAEDWHTFFGDVSNENHTVFESFQAVKQFVNEYLPDIAATTPVSGSLTYNIRIICEMTESQRNQEPVWQNWVAAVNWITNPNVVPVNESPFLKTGQSLPNPKEKGFRQNQFPIAKVLPAPRPEIPMGPSLEKVDLTQSYYAFVKFLQHYYQVSDDSELGNFLQQNRAISENNEEYRYWKGKFSRCSGNKKLLDILKAFLMVRDYFEIEFPDNALHTHPVRKLSCNLWKAAYLPHSQRIQTEVWQNWLTAVHQVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ0</accession>
    <name>F9UTZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">napA1</name>
        <name evidence="6" type="ordered locus">lp_0400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100995.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888424.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0400"/>
    <dbReference type="EnsemblBacteria" id="CCC77910">
        <property type="protein sequence ID" value="CCC77910"/>
        <property type="gene ID" value="lp_0400"/>
    </dbReference>
    <dbReference type="GeneID" id="57024209"/>
    <dbReference type="KEGG" id="lpl:lp_0400"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.332"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_9"/>
    <dbReference type="OMA" id="EDKGDMQ"/>
    <dbReference type="PhylomeDB" id="F9UTZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-333-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="8"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="394" mass="42176" checksum="A4C4762648DD14D7" modified="2011-10-19" version="1">MDFLGILCLLILATTLAGHFAHRAGIPAVIGEILVGVILGPALLNWVHLTTLVQTFSDIGVVVLMFIGGLESNLALLRKYLRPAIIVAIIGVIFPVVIMGLASRFFQFSWFESLFIGVIFSATSVSISVEVLKEFKVLDTKEGATILGAAVADDIIGVILLSIMIAMMGGQSGVAQTNLGIVLLEQVGFFIGVFIVIKWVAPYLMRLSDHLLMAASPTIMAIIICLALAWLAELVGLSGAIGAFFAGVAIAQTDYQHVVDVSIEPVGYTTFIPLFFVSVGLNMTFKGVWQSLPFIVVMTVLGVLTKLWGCGLGAKLNGFSRHSNYLVGAGMISRGEMALITAQIGFSAHLLSNDYYSDIILVIIVVTMIAPFVLKNAIHRAGQVTATHSIIEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTZ2</accession>
    <name>F9UTZ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plantaricin biosynthesis protein PlnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnR</name>
        <name evidence="2" type="ordered locus">lp_0403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888426.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0403"/>
    <dbReference type="EnsemblBacteria" id="CCC77912">
        <property type="protein sequence ID" value="CCC77912"/>
        <property type="gene ID" value="lp_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0403"/>
    <dbReference type="eggNOG" id="ENOG5032MXF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215361_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-335-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="50" mass="5407" checksum="4D34FDEB89C59CF3" modified="2011-12-14" version="1">MLNKTINIIKKYPVRSLLVALIVVFAIYVISDPSIISSFNQGLSDGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU11</accession>
    <name>F9UU11_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plantaricin biosynthesis protein PlnS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">plnS</name>
        <name evidence="2" type="ORF">lp_0424a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0424a"/>
    <dbReference type="EnsemblBacteria" id="CCC77931">
        <property type="protein sequence ID" value="CCC77931"/>
        <property type="gene ID" value="lp_0424a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0424a"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316772_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="99" mass="11396" checksum="BCBB93BA70660645" modified="2011-12-14" version="1">MAHSNKQFIINLVIASLISLALVSFSMAPAYLFLIKNNWLMITIGFVIYALEAWGLYWLYRHTARVRQLPSRDVEVPGEHCTIRDCDYCDADNGRAHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU33</accession>
    <name>F9UU33_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642010.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888467.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0448"/>
    <dbReference type="EnsemblBacteria" id="CCC77953">
        <property type="protein sequence ID" value="CCC77953"/>
        <property type="gene ID" value="lp_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="57024248"/>
    <dbReference type="KEGG" id="lpl:lp_0448"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.368"/>
    <dbReference type="eggNOG" id="ENOG502ZU5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076062_0_0_9"/>
    <dbReference type="OMA" id="IQIATRM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-374-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="319" mass="36406" checksum="E689220F84FC1741" modified="2011-10-19" version="1">MTEIKLNQTVTDLLSTANSLYPGNISVRFGDTKAGYVRHDQAQQVLDDGDLTVRVSDITAPNYTASHELLHLLLLLQGFPQITFNLTTRDQQLDEQLMAIAMELYDMVSHVLVVRKQREHNLIDEQIETLYMQGVAATIEPEPAGKADAMMTLRLLTLTDLLVFFNGELPADDLQKVTTAYPQAWPAAQKLYAVISQKPVDTPFAMRRAVVKLFKAFDDQMTAWHLPVLHGTEFVTVQSVLSERQERLEVRQLFDVYHSDLLDKNKHTRAYIGLYKSDRQNAFVLPAPAQKKSDAFFKEVYDKTVKELFQEMNLPYTLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-04-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU40</accession>
    <name>RNM5_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease M5</fullName>
            <ecNumber evidence="1">3.1.26.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNase M5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA terminal maturase M5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnmV</name>
        <name type="ordered locus">lp_0457</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease M5 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.8" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101014.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888474.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UU40"/>
    <dbReference type="SMR" id="F9UU40"/>
    <dbReference type="STRING" id="220668.lp_0457"/>
    <dbReference type="EnsemblBacteria" id="CCC77960">
        <property type="protein sequence ID" value="CCC77960"/>
        <property type="gene ID" value="lp_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0457"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.377"/>
    <dbReference type="eggNOG" id="COG1658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109405_0_0_9"/>
    <dbReference type="OMA" id="RLQMFQI"/>
    <dbReference type="PhylomeDB" id="F9UU40"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-381-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043822">
        <property type="term" value="F:ribonuclease M5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01027">
        <property type="entry name" value="TOPRIM_RNase_M5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01469">
        <property type="entry name" value="RNase_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004466">
        <property type="entry name" value="RNase_M5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025156">
        <property type="entry name" value="RNase_M5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034141">
        <property type="entry name" value="TOPRIM_RNase_M5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13331">
        <property type="entry name" value="DUF4093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00334">
        <property type="entry name" value="5S_RNA_mat_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
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            <end position="187"/>
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            <begin position="5"/>
            <end position="88"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
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        <ligand>
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            <position position="57"/>
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        <ligand>
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    </feature>
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        </ligand>
    </feature>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Prophage P3 protein 11, DNA replication</fullName>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
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            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
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        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        </citation>
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            <strain>WCFS1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890878.1">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC80364">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_149386_1_0_9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="CCC80364.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="124" mass="13822" checksum="8C55462883797353" modified="2011-10-19" version="1">MMLSMTEFKVLNMLPRGAGYPMTTPNICKVTGLKERDVREAISILINQHGVPIVANRSGHNTGMFIATDEAELNIGVTSFKNQVTTMNARIRAIEQADLNGWEKALRPDIKRLETQVSHDKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU75</accession>
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        <submittedName>
            <fullName evidence="9">Transport protein, major facilitator superfamily (MFS)</fullName>
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        <lineage>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
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                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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        <property type="gene ID" value="lp_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3392"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2826"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="VIRHNVP"/>
    <dbReference type="PhylomeDB" id="F9UU75"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2864-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCRTETA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="36"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="407" mass="43961" checksum="BA7699134AFBD5E0" modified="2011-10-19" version="1">MKGALPGWRRNLAVLWLGTFIAGMGFSEVMPFLSLYVGQMGDFSKNELTMYSGITYAVTFFVVAVVSPLWGKLADRRGRKIMLLRSSLGMAFVIGAMGFVHNIWILILLRFLQGLCAGYIPNASALIATETPKESSGTAIGILTTGYVSGNLIGPILGGVLAQVFSIRLTFIITGILLLIVFVLSLTLVHESFKPSDAPIAKRDGSLLSQFKNPTLIITLLVSTMIIQMGNNSITPIISLYVKELMHNVGPITVVAGIIAALPGISTLLSAPRLGRLGDHRGADRILVFGFVFAILMYFPQGFVSSVWTLGLLRFMIGISDGALFPTVQTLLSKNTPRELTGTIFSWNQSFQAAGSMLGSLLGGAVSGWFDYNGVFIFTALSLLLNFIGVLIFIPSMRHPFAKHSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU84</accession>
    <name>F9UU84_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein, DUF1212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_3405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneID" id="66450896"/>
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    </dbReference>
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            <begin position="122"/>
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            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="CCC80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16666" checksum="C8A1F916E658A210" modified="2011-10-19" version="1">MLHWLLTTGLFQIILAYLATAGFGVLLNIPRRAVNLSGWVGAAGWFTYEVLYHILPLGIDAKLAIGNLVAAIVIGVASGMAARYKRMPMIIFNIPSLVPLVPGGQSYRVVRNLVTGQPDLAYQYFVQVVIIAGVIAIGFLVAEFINRITLHFV</sequence>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC80405.1"/>
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    </dbReference>
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    <dbReference type="RefSeq" id="YP_004890919.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="F9UUA3"/>
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    </dbReference>
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            <dbReference type="EMBL" id="CCC80405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="197" mass="22389" checksum="EE2BDB6FE341FA05" modified="2011-10-19" version="1">MSNGTDMALISELVARERLFRARHNPEIRDCYYADATVATSWQQGPLSTFIGAESKEVDPRFVIVGSVSTPVVHLNGDKAYVELPTTTHMRMMVNGTLAELESYRRLIYRVERRDTKWKISRLTSINESDNLRPVIVGQDLHVIPQDFNGLRSSYQFLAYVRQAAGGQISQDLLGTDRPEEVERLYKETNAWLRAGV</sequence>
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    <accession>F9UUC5</accession>
    <name>F9UUC5_LACPL</name>
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        <submittedName>
            <fullName evidence="4">Cell surface protein, CscB family</fullName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="220668.lp_3452"/>
    <dbReference type="EnsemblBacteria" id="CCC80427">
        <property type="protein sequence ID" value="CCC80427"/>
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    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3452"/>
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    <dbReference type="eggNOG" id="ENOG5030I33">
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WxL_dom"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="230" mass="24209" checksum="510B6330A8E9A974" modified="2011-10-19" version="1">MKKGLLVTGRLLMTVIGCLIISNWGWFIATQAATTQSQVQVEMTPSDDDNAVSPVDPDDPSKPYPGDPVDEDNVAGTGSRGKLTIDFVSNLKFNAITTAGGPFKTTAKNEWAMIQITDRRATAAGWTLQVTPSGLQSGQQTLTTSLKLGAVQLRPGAGNVSTAPNVVNTGELVAGLANNVVIAPPNTGLGTWLVVLNRGQVPTELEVHDRQLRAGDYTGTLAWSLTNAPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>P37063</accession>
    <accession>F9ULE3</accession>
    <name>POXB_LACPL</name>
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        <recommendedName>
            <fullName>Pyruvate oxidase</fullName>
            <ecNumber>1.2.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pyruvic oxidase</fullName>
            <shortName>POX</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pox5</name>
        <name type="ordered locus">lp_3589</name>
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        <name type="synonym">Lactobacillus plantarum</name>
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    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
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            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
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    <reference key="3">
        <citation type="journal article" date="1994" name="J. Mol. Biol." volume="237" first="315" last="335">
            <title>The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Muller Y.A."/>
                <person name="Schumacher G."/>
                <person name="Rudolph R."/>
                <person name="Schulz G.E."/>
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            <dbReference type="DOI" id="10.1006/jmbi.1994.1233"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.5 AND 2.1 ANGSTROMS) OF WILD-TYPE AND MUTANT</scope>
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    <reference key="4">
        <citation type="journal article" date="1993" name="Science" volume="259" first="965" last="967">
            <title>Structure of the thiamine- and flavin-dependent enzyme pyruvate oxidase.</title>
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                <person name="Muller Y.A."/>
                <person name="Schulz G.E."/>
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            <dbReference type="DOI" id="10.1126/science.8438155"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)</scope>
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    <comment type="function">
        <text>Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate.</text>
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    <comment type="catalytic activity">
        <reaction>
            <text>H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:16240"/>
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        <text>Binds 1 FAD per subunit.</text>
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            <name>Mg(2+)</name>
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        <text>Binds 1 Mg(2+) ion per subunit.</text>
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            <name>thiamine diphosphate</name>
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        <text>Binds 1 thiamine pyrophosphate per subunit.</text>
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    <comment type="subunit">
        <text>Homotetramer.</text>
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        <text>Each monomer is divided into three domains, each of which contains a six-stranded parallel beta sheet surrounded by alpha helices.</text>
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        <text evidence="1">Belongs to the TPP enzyme family.</text>
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<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWD5</accession>
    <name>Q6LWD5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tnpR2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222048.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133756.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723592"/>
    <dbReference type="EnsemblBacteria" id="CAG17873">
        <property type="protein sequence ID" value="CAG17873"/>
        <property type="gene ID" value="CAG17873"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17873"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_8_0_9"/>
    <dbReference type="OMA" id="YRHISPK"/>
    <dbReference type="PhylomeDB" id="Q6LWD5"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="195" mass="22327" checksum="3DFCD9C20136082C" modified="2004-07-05" version="1" fragment="single">MIIGYARVSKDDQNLNRQIDQLTAYGAEKIIQEKFTGTRQKRPGITQLLQTIRAHDVVVVESISRLGRNTLDILNLIQLLHQKQIKFVSLKEQMDTETPTGRAMLQMMSVIAELERNLLADRVKEGIAASRKRGVTVGRPRIAQEKLDIAIRMYQSGDYSVKEILATNQISSGTFYREVNRLKLKKLKRKNEQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH0</accession>
    <name>Q6LWH0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tnpR1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="9">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222018.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133721.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723557"/>
    <dbReference type="EnsemblBacteria" id="CAG17838">
        <property type="protein sequence ID" value="CAG17838"/>
        <property type="gene ID" value="CAG17838"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17838"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3088"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_8_3_9"/>
    <dbReference type="OMA" id="EQIRFAY"/>
    <dbReference type="PhylomeDB" id="Q6LWH0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3138-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5 6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG17838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="184" mass="21459" checksum="8C8208C5D02038B7" modified="2004-07-05" version="1">MKYGYARVSTTDQKLANQIELLKLAGAEKIFQEKFTGTTTERPEFQKLLCVLKTGDTLIVTKLDRFARNTREALAIIQELFKENVKVNILNMGLIDNTPTGQLVFTIFSAFAQFERDMIVTRTQEGKLYAKQHDPLFREGRPKTYSDEQIRFAYELRKQGMTYKMIERKTGISKRTQQRRFKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWH3</accession>
    <name>Q6LWH3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copy number control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">repB</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222015.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133718.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723554"/>
    <dbReference type="EnsemblBacteria" id="CAG17835">
        <property type="protein sequence ID" value="CAG17835"/>
        <property type="gene ID" value="CAG17835"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17835"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3087"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_4_2_9"/>
    <dbReference type="OMA" id="NSVMVAY"/>
    <dbReference type="PhylomeDB" id="Q6LWH3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3135-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG17835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="266" mass="30122" checksum="D1B931129D33CEDB" modified="2004-07-05" version="1">MGEVITFGNFKGGTGKTTNATLACLALARAGKKTLLIDFDPQANATDIYFKTAANLGHDDIEFNQTLLASIQEEDLSRSLVTLDKNIDFIPSSADFSLYPRIMEKKFKNNYKDRVTYFSKLLASLKEKYDFVVFDLPPTISLISDSALYASDWVLIILQTQEHSLQGAESFLKYIQEQVIDEYEAPSLNLLGILPVLLKNGAPVDHSTLEVAEEEFGKENMLKTLIRNMERIKRYSIRGVFLKDQFDKKIIRLYDSVAQEIIERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWI2</accession>
    <name>Q6LWI2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orf2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pWCFS101</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR377164">
        <property type="protein sequence ID" value="CAG17826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133709.1">
        <property type="nucleotide sequence ID" value="NC_006375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAG17826">
        <property type="protein sequence ID" value="CAG17826"/>
        <property type="gene ID" value="CAG17826"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17826"/>
    <dbReference type="HOGENOM" id="CLU_3154253_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3126-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS101"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG17826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="48" mass="5393" checksum="C87B71C540E04D85" modified="2004-07-05" version="1">MFQTDASQLRLSNAKSDAGFDGFSTTQLHVVCKCALHDNTHYMIMRTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88RX5</accession>
    <accession>F9ULM4</accession>
    <name>MNME_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">thdF</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">lp_3682</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641622.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891145.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88RX5"/>
    <dbReference type="SMR" id="Q88RX5"/>
    <dbReference type="STRING" id="220668.lp_3682"/>
    <dbReference type="EnsemblBacteria" id="CCC80631">
        <property type="protein sequence ID" value="CCC80631"/>
        <property type="gene ID" value="lp_3682"/>
    </dbReference>
    <dbReference type="GeneID" id="57026857"/>
    <dbReference type="KEGG" id="lpl:lp_3682"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3075"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_9"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="PhylomeDB" id="Q88RX5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3118-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000188885" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="224"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="253"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="463" mass="51036" checksum="AAFB97A5C07E6451" modified="2003-06-20" version="1">MPTTTEFDTIAAISTPPGEGGISIIRISGDQTFNVVTQIFKGKDLSRVQSHTINYGHIVDPDTHQEVDEVMATVMRAPKTYTREDVVEINCHGGLVATNEILQLILSHGARMAEPGEFTKRAFLNGRLDLSQAEAVMDLIRAKTDKSMKVALNQLDGDLSKLIRHLRQDILDVLAQVEVNIDYPEYDAVETMTTKMLKEKATEVAQSINQLLATAKQGKVLREGLATAIIGRPNVGKSSLLNHLLHEDKAIVTDVAGTTRDVIEEYVNVRGVPLKLVDTAGIRDTEDKVEKIGVERSRKAIGAADLVLLVLDNSQPLTAEDRELLQETDQSKRIVILNKTDLPARLDQAELAQLVDLSDVLSMSVLEQSGVTQLEQRIAKMFFNEGIESSQNNVMVTNARHIGLLNQAKQALQDVQTGLAAGMPVDLVQIDMTRCWEFLGQITGDSYEDELLDQLFSQFCLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88SF5</accession>
    <name>Q88SF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disaccharride transporter, major facilitator super family (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ramP2</name>
        <name evidence="9" type="ordered locus">lp_3474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643054.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890957.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3474"/>
    <dbReference type="EnsemblBacteria" id="CCC80443">
        <property type="protein sequence ID" value="CCC80443"/>
        <property type="gene ID" value="lp_3474"/>
    </dbReference>
    <dbReference type="GeneID" id="57026689"/>
    <dbReference type="KEGG" id="lpl:lp_3474"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2891"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_9"/>
    <dbReference type="OMA" id="AATISVW"/>
    <dbReference type="PhylomeDB" id="Q88SF5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2931-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="17"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC80443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="425" mass="45711" checksum="A5B61E5A7BC0654E" modified="2003-06-01" version="1">MNNGETSTSMVKKYRPLAVAAGIGSILGSGIIVGLSATITVWQNGLGLTNSQVGIISGALTFAIAIGSLLAGQITKSFGLVKSFNWLNLIYAIGALICVFSNNYIMLLIGVIITGLASGADLPISLTVVSHDAPDDKTSASLVSSTQIFWQIGVFMSYVCAFIVSKMAGASGARIVFSILAIFALITWAWRTFSTKFRAFHEEGEQRRIDREAASQTTEKVSIKTVFAGANKGRFMAFFFSILIFYVCWNLLANTFGQFQTFTLVQAHASQSFATGAGIVLNFISLLATMAFASVAGGKYRNKFFLVGITVQFLAMLGLAMSSHSLWPIVITIGCYNIGNNIAGEAMYKVWTQEAFPVEVRASVQGFINGFSRVCCGLFALITPALVVPSAIRNTMFGFAAIVFISFVAGLTMMRLEKKHGINNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UE5</accession>
    <accession>F9UR69</accession>
    <name>HIS2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="1">PRA-PH</shortName>
            <ecNumber evidence="1">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisE</name>
        <name type="ordered locus">lp_2552</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642719.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890222.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UE5"/>
    <dbReference type="SMR" id="Q88UE5"/>
    <dbReference type="STRING" id="220668.lp_2552"/>
    <dbReference type="EnsemblBacteria" id="CCC79708">
        <property type="protein sequence ID" value="CCC79708"/>
        <property type="gene ID" value="lp_2552"/>
    </dbReference>
    <dbReference type="GeneID" id="57025972"/>
    <dbReference type="GeneID" id="66450259"/>
    <dbReference type="KEGG" id="lpl:lp_2552"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2144"/>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123337_0_0_9"/>
    <dbReference type="OMA" id="FTHEKGE"/>
    <dbReference type="PhylomeDB" id="Q88UE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2200-MON"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136363" description="Phosphoribosyl-ATP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <sequence length="106" mass="12241" checksum="B39A60A9A0AAFFD0" modified="2003-06-01" version="1">MQNMEELYELIKQRKATPKKGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPGDDELTYETADLLYHVLVLLVERGVSFDQIKQELAKREGKMSDYKDRPEIKNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88UW5</accession>
    <accession>F9UQP1</accession>
    <name>GSHAB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Glutathione biosynthesis bifunctional protein GshAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Gamma-GCS-GS</fullName>
            <shortName>GCS-GS</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName>Glutamate--cysteine ligase</fullName>
                <ecNumber>6.3.2.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Gamma-ECS</fullName>
                <shortName>GCS</shortName>
            </alternativeName>
            <alternativeName>
                <fullName>Gamma-glutamylcysteine synthetase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Glutathione synthetase</fullName>
                <ecNumber>6.3.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>GSH synthetase</fullName>
                <shortName>GS</shortName>
                <shortName>GSH-S</shortName>
                <shortName>GSHase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName>Glutathione synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">gshAB</name>
        <name type="synonym">gshF</name>
        <name type="ordered locus">lp_2336</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text>Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2"/>
    <dbReference type="EC" id="6.3.2.3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101718.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890044.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88UW5"/>
    <dbReference type="SMR" id="Q88UW5"/>
    <dbReference type="STRING" id="220668.lp_2336"/>
    <dbReference type="EnsemblBacteria" id="CCC79530">
        <property type="protein sequence ID" value="CCC79530"/>
        <property type="gene ID" value="lp_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2336"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1975"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020728_1_0_9"/>
    <dbReference type="OMA" id="EANFNPM"/>
    <dbReference type="PhylomeDB" id="Q88UW5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2014-MON"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007370">
        <property type="entry name" value="Glu_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006334">
        <property type="entry name" value="Glut_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040657">
        <property type="entry name" value="GshAB_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38761">
        <property type="entry name" value="PTHR38761"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18419">
        <property type="entry name" value="ATP-grasp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04262">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000192552" description="Glutathione biosynthesis bifunctional protein GshAB">
        <location>
            <begin position="1"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate--cysteine ligase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="751" mass="83018" checksum="605A494E7A7DCBF7" modified="2003-06-01" version="1">MELDAVGKAIVQYHLVPLVHQANLGLEVTMHRVDAHGHLATTAHPQAFGSAQQNHQLRPGFSASALKFTTPVRRDIPALMAYLKGLNTAARRSLDADERLWPLSSTPVLPDDLTNVPLADVDQVSYQRRRDLARKYELQRLMTTGSHVNMSLNEALFTRLYTETFHQQYHSYVDFRNAIYLKVAQGLVRMNWLIQYLFGASPRLAVTDTTSRPQRSSVQHPDGRYSQVTGDYTSIDRYVAKLTAAVRQQQLLSVNDFDGPVRLRSNGQLAMMARQGVYYLEYRGLDLDPTSPVGVDANAVAFVRLLASYFVMMPALPAKMVSQVNAQADQLTRQVLGENPTTASAQAVPAVQVLDALADFVKTYGLPNEDAVLLKQLKSWVTDPKKTLSAQIAMQADPLAWALERAARYQESSNERPFELAGFTALDLSSQQLAQQALTRGVQVDVVDPHANILRLTKLGRSQLVVNGSGTDLNPQALTTVLTHKAAAKQILAEHGVPVPASQTYHTANQLIADYDRYVQAGGIVLKAADESHKVIVFRIMPERGLFEQVVRQLFEQTSAVMAEEVVVASSYRFLVIDSRVQAIVERIPANIVGDGRSTVKTLLDRKNGRALRGTAFKWPQSALQLGTIERYRLDSYHLTLDSVVSRGTQILLREDATFGNGADVLDATADMHQSYVQAVEKLVADLHLAVAGVDVMIPNLYAELVPEHPEMAVYLGIHAAPYLYPHLFPMFGTAQPVAGQLLDALFKNED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-03" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VA5</accession>
    <accession>F9UQA2</accession>
    <name>KPRS2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative ribose-phosphate pyrophosphokinase 2</fullName>
            <shortName evidence="1">RPPK 2</shortName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-phospho-D-ribosyl alpha-1-diphosphate 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl diphosphate synthase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl pyrophosphate synthase 2</fullName>
            <shortName evidence="1">P-Rib-PP synthase 2</shortName>
            <shortName evidence="1">PRPP synthase 2</shortName>
            <shortName evidence="1">PRPPase 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prs2</name>
        <name type="ordered locus">lp_2166</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Part of a set of proteins in which some residues (ACT_SITE, NP_BIND, REGION and BINDING) are not conserved.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644596.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889905.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VA5"/>
    <dbReference type="SMR" id="Q88VA5"/>
    <dbReference type="STRING" id="220668.lp_2166"/>
    <dbReference type="EnsemblBacteria" id="CCC79391">
        <property type="protein sequence ID" value="CCC79391"/>
        <property type="gene ID" value="lp_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2166"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1832"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_0_9"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="PhylomeDB" id="Q88VA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1852-MON"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000141149" description="Putative ribose-phosphate pyrophosphokinase 2">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <sequence length="321" mass="35057" checksum="89EF45AD2A213B5F" modified="2003-06-01" version="1">MSTDQSYAKLKLFALNSNLPLAEKIAQRVGIPLGKSSVKRFSDGEIQINIEESIRGAEVFVIQSISEPVNDTILELLIMIDALRRASASQINVVIPYYGYSRQDRKARSREPITAKLIATLLEKDRASRVLTVDLHAAQIQGFFDIPVDHLFAAPLLASYFKDRGITDNLVVVSPDHAGVSRARKMAELLGAPIAIIDNRHPDDDDLVPSSIIGDVKGRVAIVIDDMIDTGTRFDVSADALAQAGAATVYGCATHAIFSQDAVAKLQASKFEKVIVTDTIQIPADKHFDKLVQLSVGPLLGDAIKLVHEQQPVDRLFDPRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VJ6</accession>
    <accession>F9UQ08</accession>
    <name>PYRH_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">lp_2053</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640737.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889811.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VJ6"/>
    <dbReference type="SMR" id="Q88VJ6"/>
    <dbReference type="STRING" id="220668.lp_2053"/>
    <dbReference type="EnsemblBacteria" id="CCC79297">
        <property type="protein sequence ID" value="CCC79297"/>
        <property type="gene ID" value="lp_2053"/>
    </dbReference>
    <dbReference type="GeneID" id="57025603"/>
    <dbReference type="GeneID" id="66449830"/>
    <dbReference type="KEGG" id="lpl:lp_2053"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1738"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_9"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="PhylomeDB" id="Q88VJ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1758-MON"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000143851" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="1">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="240" mass="25881" checksum="67D111F201476472" modified="2003-06-01" version="1">MSEVKYKRVILKLSGEALAGEKGFGINPPVIKTVAEELKDVYDMGVQIAIVVGGGNMWRGEAGAQMGMERAQADYIGMLATIMNALALQDNLESIGVPTRVQTSIEMRQIAEPYIRRKAMRHLEKRRIVIFAGGTGSPYFSTDTTAALRAAEINADAILMAKNGVDGVYSADPNKDASAVKFDTLTHLDIINKGLQVMDTTASSLSMDNDIPVVVFNLNEPGNIRKVVAGEHIGTTVRGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WR7</accession>
    <accession>F9UNT4</accession>
    <name>ACYP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Acylphosphatase</fullName>
            <ecNumber>3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">acyP</name>
        <name type="ordered locus">lp_1554</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638559.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889387.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WR7"/>
    <dbReference type="SMR" id="Q88WR7"/>
    <dbReference type="STRING" id="220668.lp_1554"/>
    <dbReference type="EnsemblBacteria" id="CCC78873">
        <property type="protein sequence ID" value="CCC78873"/>
        <property type="gene ID" value="lp_1554"/>
    </dbReference>
    <dbReference type="GeneID" id="49393826"/>
    <dbReference type="GeneID" id="66449441"/>
    <dbReference type="KEGG" id="lpl:lp_1554"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1307"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_9"/>
    <dbReference type="OMA" id="GTVKNNP"/>
    <dbReference type="PhylomeDB" id="Q88WR7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1334-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000326728" description="Acylphosphatase">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Acylphosphatase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="90" mass="10113" checksum="450B35E51C9988B6" modified="2003-06-01" version="1">MRAVTLKATGRVQGVGFRWATKVAADKCGVNGIVRNLMDGSVFIEAEGEDQRVQVFIDVVRQSPTDFGKVKHLEVHEVEPQNYHDFRITN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XX6</accession>
    <accession>F9UML5</accession>
    <name>RL14_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">lp_1045</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641257.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888968.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XX6"/>
    <dbReference type="SMR" id="Q88XX6"/>
    <dbReference type="STRING" id="220668.lp_1045"/>
    <dbReference type="PRIDE" id="Q88XX6"/>
    <dbReference type="EnsemblBacteria" id="CCC78454">
        <property type="protein sequence ID" value="CCC78454"/>
        <property type="gene ID" value="lp_1045"/>
    </dbReference>
    <dbReference type="GeneID" id="57024701"/>
    <dbReference type="GeneID" id="66448957"/>
    <dbReference type="KEGG" id="lpl:lp_1045"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.881"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_9"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="PhylomeDB" id="Q88XX6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-897-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000055611" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13148" checksum="313D17639E8EABF7" modified="2003-06-01" version="1">MIQQESRLKVADNSGAREILTIKVLGGSGRKTANIGDVIVATVKQATPGGVVKAHDVVKAVIVRTKSGVHRADGSYIKFDENAAVIIRDDKTPQGTRIFGPVARELRDKDFMRIVSLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XZ0</accession>
    <accession>F9UMK1</accession>
    <name>RS12_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsL</name>
        <name type="ordered locus">lp_1025</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Because the enzyme that would modify Asp-102 to 3-methylthioaspartic acid has not been found in the proteome of this organism, that modification is not predicted.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641249.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888954.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XZ0"/>
    <dbReference type="SMR" id="Q88XZ0"/>
    <dbReference type="STRING" id="220668.lp_1025"/>
    <dbReference type="EnsemblBacteria" id="CCC78440">
        <property type="protein sequence ID" value="CCC78440"/>
        <property type="gene ID" value="lp_1025"/>
    </dbReference>
    <dbReference type="GeneID" id="57024687"/>
    <dbReference type="GeneID" id="66448941"/>
    <dbReference type="KEGG" id="lpl:lp_1025"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.866"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_9"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="PhylomeDB" id="Q88XZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-883-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000146240" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="137" mass="15190" checksum="BA342DA2FF90212E" modified="2003-06-01" version="1">MPTINQLIRKGRKSKVSKSNAPALNFGYNSYKKVATNNPAPQKRGVATRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHVIRGALDTAGVEDRRQSRSKYGTKKPKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YK2</accession>
    <accession>F9ULY2</accession>
    <name>LGT_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">lp_0755</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646080.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888735.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YK2"/>
    <dbReference type="SMR" id="Q88YK2"/>
    <dbReference type="STRING" id="220668.lp_0755"/>
    <dbReference type="PRIDE" id="Q88YK2"/>
    <dbReference type="EnsemblBacteria" id="CCC78221">
        <property type="protein sequence ID" value="CCC78221"/>
        <property type="gene ID" value="lp_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0755"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.636"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_0_1_9"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="PhylomeDB" id="Q88YK2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-656-MON"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172619" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <sequence length="282" mass="32318" checksum="A665B97C0DE069CF" modified="2003-06-01" version="1">MNTVLGALNPIALRLGPIQVHWYGVIIASAVVIAVALAVREGQRRGVRPDDIYDMILWALPFTLIAARTYYVIFQWSYYRQNPGEIIRIWDGGIAIYGGLIGAGIVVILFCRSRFIPTWLMLDIAAPTVIMGQGIGRWGNFMNQEAFGRVTSLSFLQGLHLPDWLINQMYIRGAYRQPTFLYESVWDLLGFALLMLTRHRTHWYKQGDVFLTYVAWYAFGRFFTEGMRTDSLMLFNVIRVSQALSVVLFFGSIGLMIWRRHHNPNNRWYLAGSGQKVVAENK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q88YY0</accession>
    <accession>F9UL74</accession>
    <name>SYE_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">lp_0609</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640932.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888603.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88YY0"/>
    <dbReference type="SMR" id="Q88YY0"/>
    <dbReference type="STRING" id="220668.lp_0609"/>
    <dbReference type="PRIDE" id="Q88YY0"/>
    <dbReference type="EnsemblBacteria" id="CCC78089">
        <property type="protein sequence ID" value="CCC78089"/>
        <property type="gene ID" value="lp_0609"/>
    </dbReference>
    <dbReference type="GeneID" id="57024384"/>
    <dbReference type="GeneID" id="66448651"/>
    <dbReference type="KEGG" id="lpl:lp_0609"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.509"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_1_9"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="PhylomeDB" id="Q88YY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-520-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000119585" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="496" mass="56919" checksum="1A157B4045C06A45" modified="2003-06-01" version="1">MAKSKIRVRYAPSPTGHLHIGNARTALFNYLFARHNKGKFILRIEDTDLKRNVKDGEKSQMDNLTWLGIDWDEGPDKGGDFGPYRQSERKSIYDPLIQQLIDEGKAYESYMTEDELSAQREAQKARKEMPHYVYEFAGMTEDEKQAKIAAAKAAGIQPVIRFHVPENTTYAWDDMVKGKVSFESKTVGGDFVIKKRDGMPTYNFAVVVDDHMMEISHVFRGDDHVANTPKQLMIYEAFGWQPPKFGHMSLIINTETGKKLSKRDETVLQFIEQYRELGYLPEAMLNFIILLGWSPVGESELFSKREFIKMYDEKRLSKSPAAFDGKKLEWVNNQYIKKADENEVFAMSIRQLIKAGRLPQRPDMSQIEWTRTLVSLFKNQMSYTGQIVDLADLFFNGPADINDEAKAELDNDTALPVLKEFRQRIEDIDVFEATAIQKTIKSIQKDTKIKGRALYMPIRIAVSHEMHGPELPETIELLGRETTKKHLDAMIAELAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z64</accession>
    <accession>F9UKX7</accession>
    <name>DEOC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">lp_0497</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888506.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z64"/>
    <dbReference type="SMR" id="Q88Z64"/>
    <dbReference type="STRING" id="220668.lp_0497"/>
    <dbReference type="EnsemblBacteria" id="CCC77992">
        <property type="protein sequence ID" value="CCC77992"/>
        <property type="gene ID" value="lp_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0497"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.409"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_9"/>
    <dbReference type="PhylomeDB" id="Q88Z64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-413-MON"/>
    <dbReference type="SABIO-RK" id="Q88Z64"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000057236" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <sequence length="215" mass="22886" checksum="AA5D4B5E3873D71C" modified="2003-06-01" version="1">MKLNRYLDHTLLKPEATEQQIDQVVREALENHFYSVMVNPYWVKHVHAQLAGSDVATACVIGFPLGANTTAIKVAEAKQAIADGVDELDMVINIGELKGDHYDAVQQDIESVVTVGHTADKVVKVIIETALLTDGEIVKASEIVADAHADFVKTSTGFSTRGASVHDISLMKGAVQDRIGVKASGGIHTRDEALAMIDAGATRLGVSASMAIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL09</accession>
    <name>F9UL09_LACPL</name>
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        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643849.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888538.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0535"/>
    <dbReference type="DNASU" id="1061870"/>
    <dbReference type="EnsemblBacteria" id="CCC78024">
        <property type="protein sequence ID" value="CCC78024"/>
        <property type="gene ID" value="lp_0535"/>
    </dbReference>
    <dbReference type="GeneID" id="57024310"/>
    <dbReference type="GeneID" id="66448586"/>
    <dbReference type="KEGG" id="lpl:lp_0535"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.442"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112830_0_0_9"/>
    <dbReference type="OMA" id="IMRNSTK"/>
    <dbReference type="PhylomeDB" id="F9UL09"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-445-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017036">
        <property type="entry name" value="UCP035040_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035040">
        <property type="entry name" value="UCP035040_CBS_Lmo0553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="212" mass="23934" checksum="2D98460BE132B05E" modified="2011-10-19" version="1">MLLKTLVKPKERLVTITADATLEDALKVLEDSGFRCIPILDETGHIFRGNIYKMHIYRHKSRGGDMSLPVTTLLKNATKTIQVDSAFYNIFFSIKDLPYIAVLDEHGYFYGILTHTRLLDMLSQSWNVNVGSYVLTVVSVGERGDLAAMAKIITKYTSIAGCLTLDVQNGTLGYRTLFTLPENVDSEKLKRIIDNLNRKQFKVIEVEDLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL17</accession>
    <name>F9UL17_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, contains ribosomal protein S1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101050.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888546.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0543"/>
    <dbReference type="EnsemblBacteria" id="CCC78032">
        <property type="protein sequence ID" value="CCC78032"/>
        <property type="gene ID" value="lp_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0543"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.450"/>
    <dbReference type="eggNOG" id="COG1098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128762_0_0_9"/>
    <dbReference type="OMA" id="SFMRDAK"/>
    <dbReference type="PhylomeDB" id="F9UL17"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-453-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="19371" checksum="ACE261AE9A9EAB45" modified="2011-10-19" version="1">MAIEVGTKVTGKVSGITNFGAFVNLGNNQTGLVHISEVSDGFVKDIHDVLSVGDDVTVKVLSVGDDGKIGLSIRKAVDKPQGEHEHHGNHQGGNRPNNHQGNNHGHGERQTNGNHHDRSNNFHSRGGNGGGRYQSRQHEPKKQDFDSLMSGFLKDSEDRLATLKRNTEGKRGGRGGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULB7</accession>
    <name>F9ULB7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102221.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891038.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9ULB7"/>
    <dbReference type="STRING" id="220668.lp_3561"/>
    <dbReference type="ESTHER" id="lacpl-LP.3561">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80524">
        <property type="protein sequence ID" value="CCC80524"/>
        <property type="gene ID" value="lp_3561"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3561"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2971"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_2_9"/>
    <dbReference type="OMA" id="TARGITC"/>
    <dbReference type="PhylomeDB" id="F9ULB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3012-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="278" mass="31548" checksum="2065523840C8AC52" modified="2011-10-19" version="1">MRYEQLRLMTPQHFEFKLTCYWKDQLKMDYDPRRWPILLIFPGSGFIQMTEREAEPIALAFSAQGYQTMVVEYNLLDRGPVYPNAIDVGLTALKYAKNQGPPHYGDANKTILMGFSAGSHVAALTNAMGNNTEYLKTHGFGDSPLTSRLQVLGYPVIDLAAGFPKSREEAFKISPDEQYWASQNLVTDQTPPTFLWNTCADAVVPTMNSLLYAEALARHHVEYDIHTFTHGKHGLCLSTVETSRYNYPEDIEPRAANWVPLVLSWLSEMLDLTQVDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULD9</accession>
    <name>F9ULD9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent Clp protease, ATP-binding subunit ClpL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpL</name>
        <name evidence="6" type="ordered locus">lp_3583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642931.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891060.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9ULD9"/>
    <dbReference type="STRING" id="220668.lp_3583"/>
    <dbReference type="EnsemblBacteria" id="CCC80546">
        <property type="protein sequence ID" value="CCC80546"/>
        <property type="gene ID" value="lp_3583"/>
    </dbReference>
    <dbReference type="GeneID" id="57026778"/>
    <dbReference type="KEGG" id="lpl:lp_3583"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2989"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_3_9"/>
    <dbReference type="OMA" id="GRVIQEH"/>
    <dbReference type="PhylomeDB" id="F9ULD9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3033-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="5">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="704" mass="77776" checksum="749C49D36272F484" modified="2011-10-19" version="1">MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTPDEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGRENEIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSSLEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKPALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKHHHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKKLEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPVADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPTGVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTERVRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGNEALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLAKKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADLVDAEIVISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK7</accession>
    <name>F9ULK7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rbsK1</name>
        <name evidence="10" type="synonym">rbsK</name>
        <name evidence="13" type="ordered locus">lp_3660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641604.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891128.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3660"/>
    <dbReference type="EnsemblBacteria" id="CCC80614">
        <property type="protein sequence ID" value="CCC80614"/>
        <property type="gene ID" value="lp_3660"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3660"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3058"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_9"/>
    <dbReference type="OMA" id="TFCGYFA"/>
    <dbReference type="PhylomeDB" id="F9ULK7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3101-MON"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="32040" checksum="6DCF2E9BA79935D3" modified="2011-10-19" version="1">MNTVTVIGSINLDRTIRVENMPKPGETIHTKEIFSAGGGKGANQAVAAQRSGANTHFIGAVGDDAAGKTMLDLLTQEKINLAGITKMTNQSTGQAYVTVDDAGENQIMIHGGANMAFTPADVEAHRDIIETSDFVVAQFESAVDSTVEAFKIAQAAGVRTILNPAPAMEKVPAELLAVTDMIVPNETETETLTGIAITDEVSMLKASAALHALGISAVIITIGSKGAFYDIDGRHGIVPAFKVEAVDTTSAGDTFIGAMSSVLNKDFSNLEDAIRYGNRASSIAVQRFGAQPSIPYKNEITAAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULQ2</accession>
    <name>F9ULQ2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P1 protein 41, scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101114.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888655.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0664"/>
    <dbReference type="EnsemblBacteria" id="CCC78141">
        <property type="protein sequence ID" value="CCC78141"/>
        <property type="gene ID" value="lp_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0664"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.556"/>
    <dbReference type="eggNOG" id="ENOG5032REC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281866_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9ULQ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-575-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025580">
        <property type="entry name" value="DUF4355"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14265">
        <property type="entry name" value="DUF4355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="215" mass="24077" checksum="DE6B364039BA8805" modified="2011-10-19" version="1">MNKEPNNPETNPDGGKPSDEPVTFTDEQQAKIDELIGQQHAKWSKKLDQQQADFKKQLADVQKQAEERAKMTAEQKAEADRKQREADMAKHDQELATQIQEYKTKSMLLDKGISPDMLPLVMGADEETTNDNLGLLQKYVDDQVQAATEKLLTGKQAVTAGDNHTSPLETGTDNPWSEDGWNLTKQTEIYNTDKEQAQKLIASAQPISQSFYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULZ1</accession>
    <name>F9ULZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase/phosphodiesterase, EAL domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643965.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888744.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0765"/>
    <dbReference type="EnsemblBacteria" id="CCC78230">
        <property type="protein sequence ID" value="CCC78230"/>
        <property type="gene ID" value="lp_0765"/>
    </dbReference>
    <dbReference type="GeneID" id="57024471"/>
    <dbReference type="KEGG" id="lpl:lp_0765"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.646"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089605_0_0_9"/>
    <dbReference type="OMA" id="PYASEMK"/>
    <dbReference type="PhylomeDB" id="F9ULZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-665-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="236" mass="27111" checksum="B26BD2360AF72E45" modified="2011-10-19" version="1">MEPIYRYFVQPQLNLLNNTVYGYELLIKQLTPDGWRLPESFAAISSQVTSDLLIATTKILGLKVRYCAVNISREQLMDTTVAKAIIQSQVQLYPAKLVVELTEERSPKDYPDTMLIPHLRGFIEHGMQISLDDVGTGINDFKSIQEILPLASELKFALQNFRSDIKDPKIQQKLHFWRAISSEYGLRLILEGIEDAEDDRLSSHFDINLRQGYYYGKPQLLRLPGDPVNFEYPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM51</accession>
    <name>F9UM51_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101175.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888804.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78290">
        <property type="protein sequence ID" value="CCC78290"/>
        <property type="gene ID" value="lp_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0835"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.710"/>
    <dbReference type="eggNOG" id="ENOG50309KW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064731_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UM51"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-725-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="260" mass="29724" checksum="3D490FBE8B15306F" modified="2011-10-19" version="1">MQKRRFFLKGSAAEVAWLNRQAARGYQLTAIHGLSYQFKEVSQARQLIAEYMPQTTLQAMTTVFQPLTSYTFHDDMTVVYSTVAPKQRVVNNDQQYRLAVYRHARDVALNWLNGWVLVVWLMMSATIVISSQLQATPLLTRLLLLGLALGAGVMVAGIIVGVRTAIRCHREVCRLIRITGDDHETWKPTFHVLFKHQQAAPDTTCWDDLGSWQLALHNQRGDYYFELKTTLSELEITNTLAQRFSKQDFSVVSWLGLYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM53</accession>
    <name>F9UM53_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643998.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888806.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78292">
        <property type="protein sequence ID" value="CCC78292"/>
        <property type="gene ID" value="lp_0837"/>
    </dbReference>
    <dbReference type="GeneID" id="57024534"/>
    <dbReference type="KEGG" id="lpl:lp_0837"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.712"/>
    <dbReference type="eggNOG" id="ENOG5030AEU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2649944_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-728-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="76" mass="8472" checksum="7A0C5CDC01F8B225" modified="2011-10-19" version="1">MSEQDQAAWAIQALAALKTADNQVVVESIIKVIDDQQAEIESLRGSMEGQLWSPTSWHQDQQAQRAAHEDKSTTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM74</accession>
    <name>F9UM74_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxK</name>
        <name evidence="3" type="ordered locus">lp_0863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2009-04" db="PDB data bank">
            <title>Crystal structure of pyridoxal kinase from Lactobacillus plantarum.</title>
            <authorList>
                <person name="Bagaria A."/>
                <person name="Kumaran D."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 2-272</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2009-06" db="PDB data bank">
            <title>Crystal structure of pyridoxal kinase from Lactobacillus plantarum in complex with ADP.</title>
            <authorList>
                <person name="Bagaria A."/>
                <person name="Kumaran D."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-272 IN COMPLEX WITH ADP</scope>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2009-07" db="PDB data bank">
            <title>Crystal structure of pyridoxal kinase from Lactobacillus plantarum in complex with ATP.</title>
            <authorList>
                <person name="Bagaria A."/>
                <person name="Kumaran D."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-272 IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="3 4" key="5">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
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        <property type="chains" value="A=2-272"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="69"/>
            <end position="251"/>
        </location>
    </feature>
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    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
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    <feature type="binding site" evidence="6 7">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
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            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888842.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0885"/>
    <dbReference type="EnsemblBacteria" id="CCC78328">
        <property type="protein sequence ID" value="CCC78328"/>
        <property type="gene ID" value="lp_0885"/>
    </dbReference>
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    <dbReference type="GeneID" id="66448832"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="168"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="32908" checksum="6C6F052E01DB8A1C" modified="2011-10-19" version="1">MRVVKKINNNVVVCLDQHGEELVAFGKGLGFQKVPYELTDMTKVTMTFYKLNYQYYQLLKEIPTEIFDLSAAIVERAQALIPRILNPNMIFSLADHINFAITRLTHYKSAQLPFSYDVEQLYPQETDVGYYAVRLINRRLNIQLPVSEVTAIAMHFVNSQTNDLATNSSVNSDDEMIKIITKIIEQEYELRINQTEFTYNRFVMHLRYYIKRMKKHEQISENDNSKLFNTMRHDEPEIYLVAKRIADYVDSQLDTNSNDDELFYLMIYVKRIVNKINTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM93</accession>
    <name>F9UM93_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888846.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0889"/>
    <dbReference type="EnsemblBacteria" id="CCC78332">
        <property type="protein sequence ID" value="CCC78332"/>
        <property type="gene ID" value="lp_0889"/>
    </dbReference>
    <dbReference type="GeneID" id="57024573"/>
    <dbReference type="KEGG" id="lpl:lp_0889"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.753"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_3_2_9"/>
    <dbReference type="OMA" id="EAYELTF"/>
    <dbReference type="PhylomeDB" id="F9UM93"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-768-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16351" checksum="AB805F85685756F2" modified="2011-10-19" version="1">MKTTTIRPLEDHVCFSTYTTVHAIQRLYQPTLTAHRLTYPQYLVLVALYATPPHAVTVKTLSTQLNLSTGTLTPVLQRMTQAGLITRHRNPQDERSILLTLTPQGTATRLALNDLPDLLTAKGGLNQSEWAQLTQLMTKLMTNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM95</accession>
    <name>F9UM95_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888848.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0892"/>
    <dbReference type="EnsemblBacteria" id="CCC78334">
        <property type="protein sequence ID" value="CCC78334"/>
        <property type="gene ID" value="lp_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0892"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.755"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_9"/>
    <dbReference type="OMA" id="FFLAHEN"/>
    <dbReference type="PhylomeDB" id="F9UM95"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-770-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16953" checksum="32E28089E6C2A024" modified="2011-10-19" version="1">MIKMNHDEMVARQVLILARQIKRRRNQHLRTVGLTTEQADALTFFTDQPGRTVTAFKTYQEITHQTARMIVQRLQTRGYVQLVVSPTDARAKQVVVTPSGRAKREQLRQHGWQTSAQMFAHLDAEQQQVFLDLLRQVNQNLESDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM99</accession>
    <name>F9UM99_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="9" type="ordered locus">lp_0896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641141.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888852.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0896"/>
    <dbReference type="DNASU" id="1062774"/>
    <dbReference type="EnsemblBacteria" id="CCC78338">
        <property type="protein sequence ID" value="CCC78338"/>
        <property type="gene ID" value="lp_0896"/>
    </dbReference>
    <dbReference type="GeneID" id="57024579"/>
    <dbReference type="GeneID" id="66448842"/>
    <dbReference type="KEGG" id="lpl:lp_0896"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.759"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_2_9"/>
    <dbReference type="OMA" id="FNNHAHV"/>
    <dbReference type="PhylomeDB" id="F9UM99"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-774-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="207"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="333"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC78338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="431" mass="47764" checksum="F2514DE3865A4ECF" modified="2011-10-19" version="1">MSETNAQKVQEVIIAGMSKTVANYDYAMSELEALVAANNMHAALRIDQGLEKPNPATFFGKGKVVEIKEVAAANDLHIMVINADLTPSQVRNLEEQTDIQIIDRTGLILEIFGNRARSKEAKLQVKIAQLQYQLPRLRTSISNRLDQQAGAAAGGGGGFTNRGAGETQLELNRRTIQDRISHAKHELKELNKDEVVRRSQRDKAGLPNVALVGYTNAGKSTTMNGLVKLFGKGEDKQVFEKDMLFATLDTSIRQLTFPDNKQLLLSDTVGFVSDLPHNLINAFRSTLAEAANADLLIQVIDYADPHYKEMMATTEKTLKEIGVHDVPMIYAFNKADLTEADYPNQQDDQLIYTARDEASLQALTSMIKAKVFKNYVTTTLLIPFNDGEVVAYLNDHANILKTDYLADGTQLTVELNTVDAQRYEKYVVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMB9</accession>
    <name>F9UMB9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound protease, CAAX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101204.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888872.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0919"/>
    <dbReference type="EnsemblBacteria" id="CCC78358">
        <property type="protein sequence ID" value="CCC78358"/>
        <property type="gene ID" value="lp_0919"/>
    </dbReference>
    <dbReference type="GeneID" id="57024599"/>
    <dbReference type="KEGG" id="lpl:lp_0919"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.778"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218515_0_0_9"/>
    <dbReference type="OMA" id="HFVNNIV"/>
    <dbReference type="PhylomeDB" id="F9UMB9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-794-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="230" mass="25571" checksum="2B24E0FF746214B5" modified="2011-10-19" version="1">MSKSHSTNRTVTWLLNIVKLIGLFALYQLAMIPTMMPAIRHGFSATATLIAGVASLVLLGSLIWWLVTIYRRQAPIVTSLSRPTRPVLTIVGLFILVELGNVLAGLIVKQTPENQVILDKVFTTSPVINVVMMAVLAPIVEELIFRGLMYRWLFPRVTNWVSFTVALVFASLVFALAHTLSFSPALLAYLPIAVVLTFTYVWFNDIRYSIALHIINNSLAMVGMLTLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMD0</accession>
    <name>F9UMD0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
            <ecNumber evidence="2">4.1.1.-</ecNumber>
            <ecNumber evidence="2">5.3.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.-" evidence="2"/>
    <dbReference type="EC" id="5.3.3.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888883.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0931"/>
    <dbReference type="EnsemblBacteria" id="CCC78369">
        <property type="protein sequence ID" value="CCC78369"/>
        <property type="gene ID" value="lp_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0931"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.790"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_0_9"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="PhylomeDB" id="F9UMD0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-805-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="276" mass="29909" checksum="1A77ABA3BE3DBC61" modified="2011-10-19" version="1">MYNNINEVINMKIGMRANRPFIITDEQHGQTVLNAKTVLEALHTPAADRQLGSLETFAPQELAAPITAPRQIFAVGMNYRDHSAEIHITLPKVPSIFTKFSSSLAPANVTMATHGPETDWETELVVMIGKGGRDIATADAMAHVAGVMVGEDLSDRAVQFENDNPQFSIGKSFENYAPVGPWLTTVDELANLDDEVITTTVNGQTMQQAPLSQLIFKVPDLVHYLSTVCELQPGDLIFTGTPSGTGVGRNPQVFLQAGDQLCGQITHLGTLNITIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UME7</accession>
    <name>F9UME7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888900.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0951"/>
    <dbReference type="DNASU" id="1063953"/>
    <dbReference type="EnsemblBacteria" id="CCC78386">
        <property type="protein sequence ID" value="CCC78386"/>
        <property type="gene ID" value="lp_0951"/>
    </dbReference>
    <dbReference type="GeneID" id="57024627"/>
    <dbReference type="KEGG" id="lpl:lp_0951"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.808"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="OMA" id="INDQVIL"/>
    <dbReference type="PhylomeDB" id="F9UME7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-822-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="308" mass="34583" checksum="5B2F38C689570717" modified="2011-10-19" version="1">MENKLLVFLEAIQQHNSMTKAAQSLFISQPYISRTIKSAETHFGTPLIDRGHHPLELTYAGERLLTYLQSDARLHQRMNTELKEISQNKYQSMTIGITPPMANAWFSQTLPAFYQRFPNIRTKILEITTSKAETLLASHQLDFFIGKTIHQTNVKTIPLQTISLSLVIPKTAGIYQSNQFWRPFTPTILTGMTGEPVIRAVGEARFQELVDHYFADKGIQTIPLIEVDNSRFALSLTLQGLGSIVLATAMLARLATEPAKYPINAFKLPTSELSLDFSIAYLPSHVLAKPIAYLVEQACQTFNPAIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMF5</accession>
    <name>F9UMF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_0960a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641199.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888908.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0960a"/>
    <dbReference type="EnsemblBacteria" id="CCC78394">
        <property type="protein sequence ID" value="CCC78394"/>
        <property type="gene ID" value="lp_0960a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0960a"/>
    <dbReference type="eggNOG" id="ENOG5030A89">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465160_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-830-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="10169" checksum="D913F4868DAD2BE1" modified="2011-10-19" version="1">MQSKNLTVKYLNKSKILKLDPFMLYLQVTPLKATEPMPINCIIVKHALTLFYQLQPDAQLALYGHYNTRHQFVITKFMVRSAVQTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMI7</accession>
    <name>F9UMI7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2007-12" db="PDB data bank">
            <title>Crystal structure of putative carboxylesterase (NP_784706.1) from Lactobacillus plantarum at 2.09 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641232.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888940.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3BJR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.09 A"/>
        <property type="chains" value="A=1-264"/>
    </dbReference>
    <dbReference type="PDBsum" id="3BJR"/>
    <dbReference type="SMR" id="F9UMI7"/>
    <dbReference type="STRING" id="220668.lp_1002"/>
    <dbReference type="DNASU" id="1063602"/>
    <dbReference type="EnsemblBacteria" id="CCC78426">
        <property type="protein sequence ID" value="CCC78426"/>
        <property type="gene ID" value="lp_1002"/>
    </dbReference>
    <dbReference type="GeneID" id="57024666"/>
    <dbReference type="KEGG" id="lpl:lp_1002"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.849"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_2_9"/>
    <dbReference type="OMA" id="MYPVISM"/>
    <dbReference type="PhylomeDB" id="F9UMI7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-862-MON"/>
    <dbReference type="BRENDA" id="3.1.1.2">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3BJR"/>
        </source>
    </evidence>
    <sequence length="264" mass="28737" checksum="87C033A4AE3CD69D" modified="2011-10-19" version="1">MQVIKQKLTATCAQLTGYLHQPDTNAHQTNLPAIIIVPGGSYTHIPVAQAESLAMAFAGHGYQAFYLEYTLLTDQQPLGLAPVLDLGRAVNLLRQHAAEWHIDPQQITPAGFSVGGHIVALYNDYWATRVATELNVTPAMLKPNNVVLGYPVISPLLGFPKDDATLATWTPTPNELAADQHVNSDNQPTFIWTTADDPIVPATNTLAYATALATAKIPYELHVFKHGPHGLALANAQTAWKPDANQPHVAHWLTLALEWLADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN05</accession>
    <name>F9UN05_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cps2K</name>
        <name evidence="1" type="ordered locus">lp_1207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101308.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78594">
        <property type="protein sequence ID" value="CCC78594"/>
        <property type="gene ID" value="lp_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1207"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1025"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825729_0_0_9"/>
    <dbReference type="OMA" id="TMFAMRI"/>
    <dbReference type="PhylomeDB" id="F9UN05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1037-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="66" mass="7586" checksum="4340B0BABB6D4F8A" modified="2011-10-19" version="1">MSTDTNDKTMFAMRISKQEKSQLKRLYADLGLDLSTAVNLFFRQSLVENGLPFQPMRASSRENKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN82</accession>
    <name>F9UN82_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell surface SD repeat protein,membrane-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdr</name>
        <name evidence="5" type="ORF">lp_1303a</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1303a"/>
    <dbReference type="EnsemblBacteria" id="CCC78671">
        <property type="protein sequence ID" value="CCC78671"/>
        <property type="gene ID" value="lp_1303a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1303a"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000323_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022263">
        <property type="entry name" value="KxYKxGKxW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19258">
        <property type="entry name" value="KxYKxGKxW_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03715">
        <property type="entry name" value="KxYKxGKxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3343"/>
            <end position="3363"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="3251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3285"/>
            <end position="3339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="3176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3177"/>
            <end position="3251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3299"/>
            <end position="3325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="3378" mass="334906" checksum="6CF54B21DD88F03C" modified="2011-10-19" version="1">MKFLRHKSFRGDPQVHYKMFKVGRTWVFTAMASFVLTAAPQLVSHADTVSADTSSDTASSATSSASSGADTSSAAASAAALAAATASSTSTSTTSDSSTASSSSETASNSNSESSSDSSSSDDSASDASSASETSTTNATSTSSTSSSSVSTASSSASSASSSSSSSSSSATSSSLTDSSSSSAASSSTTSLSSSASVAASTVSTASSVASTTKSASTAASTAAIAAYSSVSAASSHTDSTAAKAASSSASLAGSYATLASSYASLVNNLTTQAAVSAAQSAYQEALNAADLSRHYNSIANMYLDALTNGVGSNVDNAIAYSGANSLAYSAASAASSYAALASTATSTASSAATQGLINLASSNYSAASSAASAATVAASSAAEAANSAYLAMQYDKNNTAVTSAYTVASSTAAAASTAAVNATTAAVAASSAYAAVSSNAANNDYEATSTAYAVTSSAATEALGQYAAGSTASSAASFANSTAISDLASAASSSANVANTAKSTASSAASVAATQTGTQASAYASSAATAASSASSAYAVASTAAKSAVSASDPATADSYARVAQSASSLAASYAATAESNATLAAKFSTDVANEQTVSSNATLTTSTATQSVSTGDTVTITNKVGLDSGYSVSGTPTYVWYVSTDGTTWTTISGATSATYTTTATTSGTYYYQAVVSGKRVTAIILTSSFKAAGNVITIVVTNPEGTYTEIASSYASQANSAASVATSQAVAASSAISLASSSANLTGSLASYYTSQANSSYNAASSYASVASEAASIATMASTSAASYEAEGAYTSANIWAGMASSYASVATEYASSASSAASEAAASLDTALKNAVNEDGGDTAADYLASSYASMAASSANVAGDQASLAASYAANAANAYNVAGSSFNTTATSSYNAAASSAAVAASSYAAAASEAASLAASYAADGNYNSAALQQSYAALRLTYATDQLNAASSAASAITQTVVQAQSSYYNSIATAASSAASAAESAAGNAISVASSLSAKYASNTTLGSSYVAQTNNYAVTTLGAAAAATSAAEMAAQYTSQASSAVAAGDYAMASSYVTNASAAASEATSYAALSTSNAALGSTAASNATNYSNNTNSYKSTNTGNATTILGIVISGGMTSQPAAVTSTVSGGTFTLSASSALGLGGVALSSKTTWYVQVNGTWMTLDKASAYIESYDAVDSAGLLSTSSSLTVTIKAGYTGSLLFQAVQGFSWDLANWFTVYTFASNLAEVDVYSSNIPATNISIAGDDYVINPTNSSSGSNDKVTSQFTSTTNPENATGKITWTTSDSSIATIDDSGLLTVVSNGTVTITATITNADGTSYSSSKTITIGSGLEDTSVDAGSDLTWVPDGSTTGTGTDITYQWYYSSTADGTGTALSGQTGTTLNLSDLTVGQSGYYYLVITGSNTTNGTTTTTTVTLGRAYLTVNAVSTEAADSAASEAANYANQATEYGSVASSYANIAGEYASKNSEASSYAEQATAAASDAQSAATAASTAASNAAAAQSNADSAEAAGENSAASSYAEEAKKKASEASEAKKKASSAADDAGYYADLAANVSEDDSDSDSDGDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDGDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSNSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDADSDSDSDSDSDSNNDSDSDTITDSDSNDGTNSDNGSNSGSDGSSSSNTGSGSGNTTGSTGNNSGTGTGTTTSSTASNNGAASTSTTSLSAAATSGVSATAATLAVTTPSSDGAATTSATAATSVVYAAASAQDVDATSDQTDSDSKSSNDSDKDKKSADTDSADDKVGSSNTDENGKTASDTSNNAGTIFGGLLTAAAAAGLGWWFFLFGRRRKDDDEDDENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNB3</accession>
    <name>F9UNB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101365.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889216.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1348"/>
    <dbReference type="EnsemblBacteria" id="CCC78702">
        <property type="protein sequence ID" value="CCC78702"/>
        <property type="gene ID" value="lp_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1348"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1134"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129906_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1160-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="132" mass="14842" checksum="61BB8F8445B63D03" modified="2011-10-19" version="1">MPFIMAKVNQKITAQQKYQLKSGLGQAIGFVPGKSEEVLMVGIEDQYDLYLHGDDRVNLAYISVAIYGIPHHEGYVNLNLAITKLFYEVLKIHPENIFIDYADIRAWGNSGYFIDGKGVHVPDKNASSSFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNH9</accession>
    <name>F9UNH9_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101404.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889282.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1435"/>
    <dbReference type="EnsemblBacteria" id="CCC78768">
        <property type="protein sequence ID" value="CCC78768"/>
        <property type="gene ID" value="lp_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1435"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1201"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008413_3_0_9"/>
    <dbReference type="PhylomeDB" id="F9UNH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1229-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="33"/>
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    </feature>
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            <end position="411"/>
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            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC78768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="849" mass="95884" checksum="A57931B2CF95FC86" modified="2011-10-19" version="1">MWPNYQTRRWQVAVTAGLLSLAIMGIVFAIWGITPFGNHNLLISDMGGQYLSFFTAYRHAILTHSFQLYSFSQSLGSNALPTIAYYLLSPFNILMLLFPAANLPTGLSLLIMLKISLIAVTMTAFLQTHFQTKRWSTAIFGVAFSLSGFVALNYFTIMWLDALIWLPLVIQGLDHLIATSHPGRFFGWLWVSIVTNYYLGYMTCLFVIYYFIYQLFERKRPQDSLWQTVRHQFSLIRHVVVTMLLSGLSTMFVLIPTGLGMLTTAKSAVKLSSYLPVPQFGLAVLSQFGLGAANFTTRLVHAPTVFSSSLVVLLALSFWVQPNLTKAHKWHSFGLLLALFLSMDIRTLDTIWHMFQTPAGFPYRNAFFFSFVLIMIAFEAWLAGPRRIALRWQWLLPTLMVSALILGWFAQRTAKHPLTTSTLALSLVAVILTAIALFATAKRWQTLSLAGIVALELGTNSTLMMAKSPLGNQAKFVTAYRTEYRQMQAVNDPDGQLYRVENQNTLINQAYNYDSKYRNYNDPMLFNFHDITYYSSTFANQTRLMLKSLGLFSKNARRVSSEGLNPVTDLLLDVKYAVQLNAVGQATTRLRSQNGLGFAVPTAFRQLKLRQNSAIINQERLLQSLRPSKRAYFGNATMLSDHVIQDSQAKRYPYLHTVKLRMTRTGTLYYNDTTRQTKYTTMRVNGHLVPTKFNANGELVLRSLGYFDKGAVVTLTVKRTQPTLGTHVHIASLDQARFNQVKQQLLSTRFTPTYHVSGIHTVVSGQVTNRSKQKWLYVAIPADKGWRATVNGVKVTPKTVIGGMLALPIQPGKNQIQLTYHVPGLLGGLLISIISGLSFILWRQRYRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM0</accession>
    <name>F9UNM0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nitrite extrusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">narK</name>
        <name evidence="11" type="ordered locus">lp_1481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101427.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004889323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1481"/>
    <dbReference type="EnsemblBacteria" id="CCC78809">
        <property type="protein sequence ID" value="CCC78809"/>
        <property type="gene ID" value="lp_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1481"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1243"/>
    <dbReference type="eggNOG" id="COG2223">
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    </dbReference>
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    <dbReference type="OMA" id="DAWWFMF"/>
    <dbReference type="PhylomeDB" id="F9UNM0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1270-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="396" mass="42932" checksum="BF8C2E6332A1A248" modified="2011-10-19" version="1">MTVEDAQTSTRWRAYLALGLATVAMIVCFMSWSNFAPLAGELAIKFHLSVSQRTLLLATPVLLGSIMRIPVGILSDRYGGKKVYLILMAFILIPLLMITKVHTYGMLLVAALLVGMAGTSFAVGVSYASVWFPPEKQGLALGIVSMGNMGNAVAALTLPSISTSYGFNMVYYFLMVLTVILAVLFAIFCREMPVDKTKTVTGALAVAKESSTWYLSLFYFLTFGLFVSFTNLTPLFLEDIFRVPQVTAGLYAALFAGLCTVVRPIGGAAADKWRPMQMLQWIFIGITVFAVIITLTFSNQSLFIFGIVGAGLIAGFGNGVIFKMVPYVLQGNTGAVTGFVGALGGLGGFFPPLLVGWIHTWTGSYRLGIVLLALTGLVCWYALWRRFIHGDVHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNN5</accession>
    <name>F9UNN5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin biosynthesis protein MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moeB</name>
        <name evidence="3" type="ordered locus">lp_1496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101442.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1496"/>
    <dbReference type="EnsemblBacteria" id="CCC78824">
        <property type="protein sequence ID" value="CCC78824"/>
        <property type="gene ID" value="lp_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1496"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1258"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_1_9"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="PhylomeDB" id="F9UNN5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1285-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="344" mass="38415" checksum="126506856F3AB43E" modified="2011-10-19" version="1">MLNRYDRQERVTVIGHDGQRRINAATILIVGVGALGSYAAEQLVRAGVGHLILVDPDTVSLTNLQRQALFTEADVRDQALKVDAAKNHLQAINHHVEITAYPAALDGDLLQTLTFDLVLDCLDNYGTRILINRAALVERFDYIFASCAGTFGTVMPIRAWQHACLNCVYHNLEALQQTDCDLLGVNTALVPIIAGLQVSLALHYLVAPTSVDFEQLTTIDNWQLSQQTFHVRKNPNCPTCQRTDWDLTTAPITNPVQVLCGTATYQARFTQKPNLAAITDWLLDRQFSIKSYASFISFKWEDRPISIFKNGKVMLYNIPDLDAATATFNRLQLYLKSVLEVPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNU7</accession>
    <name>F9UNU7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transpeptidase (Penicillin binding protein 2B)</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbp2x</name>
        <name evidence="8" type="ordered locus">lp_1568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640321.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889400.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1568"/>
    <dbReference type="EnsemblBacteria" id="CCC78886">
        <property type="protein sequence ID" value="CCC78886"/>
        <property type="gene ID" value="lp_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1568"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1320"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_7_0_9"/>
    <dbReference type="OMA" id="YQVVHGS"/>
    <dbReference type="PhylomeDB" id="F9UNU7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1347-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="7">
        <location>
            <begin position="67"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="6">
        <location>
            <begin position="343"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="678" mass="72671" checksum="0DB65D7D0FD7A9AE" modified="2011-10-19" version="1">MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANNTTATGNVQRGSIYDSTGRVLVGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTLTDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYAEKHIINNLTSTQKNAAAIYYKMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVTTEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKKYGGQKGDNVQLTINSKFQKKVQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGASRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGVITPTNSTLTDTPIKLAGTATKSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGYFNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGGQRIAPHIVSAITGTKSNGSQGAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQRTGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYKNPKVVIAVAFPGITATSGDYNMVVAKQIYAAFWKYYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP07</accession>
    <name>F9UP07_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">ffh</name>
        <name evidence="13" type="ordered locus">lp_1635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101484.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1635"/>
    <dbReference type="EnsemblBacteria" id="CCC78946">
        <property type="protein sequence ID" value="CCC78946"/>
        <property type="gene ID" value="lp_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1635"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1382"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_9"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="PhylomeDB" id="F9UP07"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1409-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="100"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="11">
        <location>
            <begin position="101"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCC78946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="484" mass="53902" checksum="EF6EEFAA58961C95" modified="2011-10-19" version="1">MAFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERALGAKVLEGLNPAQQIVKIVDEELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGKLALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPVFQLGTDVDPVEIVRQGMAQAKENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDKLDVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGDMLTLIEKAQQQYDEKQAEEMNLKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANNPAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRRRIAAGSGRPIHEVNRMIKQFNQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP45</accession>
    <name>F9UP45_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fabI</name>
        <name evidence="10" type="ordered locus">lp_1681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645117.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889498.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1681"/>
    <dbReference type="EnsemblBacteria" id="CCC78984">
        <property type="protein sequence ID" value="CCC78984"/>
        <property type="gene ID" value="lp_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1681"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1420"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_9"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="PhylomeDB" id="F9UP45"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1447-MON"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
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        </ligand>
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        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="161"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="252" mass="26881" checksum="E67728C1405991A5" modified="2011-10-19" version="1">MDGILSGKTIVVMGVANQRSIAWGCTEALIAQGAQVILTYQNDRLKQSLQRFVAPDVPLIACDVADDDNVERAFASIKQQYGAIDGIIHAIAYADKATLEGDFVNTTKAGYDLAQNISAYSLIAVARAARPMLKPGASLVTLTYFGSERAVPNYNMMGVAKAALEANVRYLARDLGPQQVRVNAISAGAVKTLAVTGIHEHQQLLKLSRSMTVDGEPVKTREIGNVAAFLLSNLSTGMTGDVVYVDKGVHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP56</accession>
    <name>F9UP56_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Transcription regulator, C-terminal</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78995.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_1693a"/>
    <dbReference type="EnsemblBacteria" id="CCC78995">
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        <property type="gene ID" value="lp_1693a"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1693a"/>
    <dbReference type="HOGENOM" id="CLU_2287942_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1458-MON"/>
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    </dbReference>
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            <dbReference type="EMBL" id="CCC78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="101" mass="11498" checksum="B6ADE3DE3CA9F9D0" modified="2011-10-19" version="1">MLEFIWPHRDKIELLARNDLLVPLLTRHIQTIVALLLSVNVPWRKNGSNDQHYEYMLTYSIGGFGVLLDTLFKKSTPLSPGQISKALSRALNEIAIQVNIK</sequence>
</entry>
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    <accession>F9UP60</accession>
    <name>F9UP60_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Adherence protein, chitin-binding domain</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">lp_1697</name>
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101515.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889513.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UP60"/>
    <dbReference type="STRING" id="220668.lp_1697"/>
    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC78999">
        <property type="protein sequence ID" value="CCC78999"/>
        <property type="gene ID" value="lp_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1697"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1433"/>
    <dbReference type="eggNOG" id="COG3397">
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    <dbReference type="HOGENOM" id="CLU_047929_2_0_9"/>
    <dbReference type="OMA" id="STWDYYI"/>
    <dbReference type="PhylomeDB" id="F9UP60"/>
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    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="201" mass="22229" checksum="4FCD71779D4E2A74" modified="2011-10-19" version="1">MLSTKKNHVLRYLFIIVGMMIAFLGCGVIQVSAHGFVTNPGGRAYLGSTWYPGGPLNTNIGSVMYEPQSIEAPQNTFIDGKIASAGIANFAPLDEQNAKRWYKTPVKAGNLSVTWQLTARHKTSTWDYYITKPSWNPNAPLKFSDFKKIASYNDNGAIPSEFVTHQVNISANEKGYQVLLSVWNIADTGNAFYQVSDIDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP88</accession>
    <name>F9UP88_LACPL</name>
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        <recommendedName>
            <fullName evidence="2">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.4.2</ecNumber>
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    <gene>
        <name evidence="9" type="primary">mvaK2</name>
        <name evidence="9" type="ordered locus">lp_1733</name>
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    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC79027">
        <property type="protein sequence ID" value="CCC79027"/>
        <property type="gene ID" value="lp_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1733"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1462"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_7_0_9"/>
    <dbReference type="OMA" id="ACIVYED"/>
    <dbReference type="PhylomeDB" id="F9UP88"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1490-MON"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphomevalonate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005917">
        <property type="entry name" value="Pmev_kinase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="entry name" value="PTHR31814"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01220">
        <property type="entry name" value="Pmev_kin_Gr_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="7">
        <location>
            <begin position="113"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="8">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="363" mass="39555" checksum="0EA205BAFD01943D" modified="2011-10-19" version="1">MITVKAPGKLYIAGEYAVVESGYPAIIVALNQFVTATISPSETIGSIVSEQYQENSIVWRRQGDAMVFDNRDNPFHYILAAINLTESYAHELGRELGVYHLGINSELDSADGKKYGLGSSAAVTVATVKALCQFYHLPMDKNKLFKLAAIAHLSVQGNGSLGDIAASVYGGWIAYHSFDRQWLHLQQAQSSLSDLLTMPWPDLKIELLTPPAALRLMIGWTGSPASTSHLVDKVALVKAKQRSEYQTFLKASKACLKRMITGFHHSDLHVIQTELRTNRQLLQKLGGFSHVTIETPLLQRMIQLAESAGAAAKTSGAGGGDCGIVLIDQTIDPRPLLTAWAHDGIEQLNLNVHTVQDTVLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP96</accession>
    <name>F9UP96_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication protein DnaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaD</name>
        <name evidence="3" type="ordered locus">lp_1741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644365.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889549.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1741"/>
    <dbReference type="EnsemblBacteria" id="CCC79035">
        <property type="protein sequence ID" value="CCC79035"/>
        <property type="gene ID" value="lp_1741"/>
    </dbReference>
    <dbReference type="GeneID" id="57025363"/>
    <dbReference type="KEGG" id="lpl:lp_1741"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1469"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091656_0_1_9"/>
    <dbReference type="OMA" id="FHYKDIF"/>
    <dbReference type="PhylomeDB" id="F9UP96"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1498-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="241" mass="27375" checksum="3812078F5C395404" modified="2011-10-19" version="1">MESLAAALVNDGQTTIANALLAHYREIGVTNDELLVYLQFKRLIDQGNQFPDAAVIAKSLGESTNAVFQRLHEMLAKKLLTIESITADDQKIHDRYNFDGLYDKLAVALKKQPVSTQASEQATSENSRQKVFRAIQTEFGRDLSPIEMESISKWFDEDHYEPEVIELALREAVLRQVYNLTYMDRILLNWQKRNLKTAAQVEAERQRSIEQRLNSAPQPQRQTGANAGPKIPLFKLGEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPA0</accession>
    <name>F9UPA0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-methionine ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640478.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889553.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1746"/>
    <dbReference type="EnsemblBacteria" id="CCC79039">
        <property type="protein sequence ID" value="CCC79039"/>
        <property type="gene ID" value="lp_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1746"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1472"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_1_2_9"/>
    <dbReference type="OMA" id="PHTIVFG"/>
    <dbReference type="PhylomeDB" id="F9UPA0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1502-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="285" mass="31598" checksum="9B7D7A06828A0C15" modified="2011-10-19" version="1">MKRLAWWLIGIAAIVGICVGLHEITSYSARTQQSATITVGSMGSDYEVWQHIAKSQDAKKMGLTIKVKQITDGVQLNKATADGNVDVNAFQSWSYYQTYNQQNPKAKLAALGTTYLEPMGIYSKKYQSVDEIPDGATIAIADNPSQASRGLLLLQKAGLIKLAANFGVLGSVKDITSNPRHLKFKQIDDTTGPRIIKSVDAVLISNTVALEGHLHVLRDSIFHESLNKSTRDNVNILATAAKNEHRASYLKLVKLYHRADIQKYIKQKYYGTKININKPLSYFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPB3</accession>
    <name>F9UPB3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101537.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889566.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1762"/>
    <dbReference type="DNASU" id="1062611"/>
    <dbReference type="EnsemblBacteria" id="CCC79052">
        <property type="protein sequence ID" value="CCC79052"/>
        <property type="gene ID" value="lp_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1762"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1486"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123773_0_1_9"/>
    <dbReference type="OMA" id="IEKWFCQ"/>
    <dbReference type="PhylomeDB" id="F9UPB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1516-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="135" mass="15850" checksum="4540BA6B889365D9" modified="2011-10-19" version="1">MTEIETALLRDRKAKVQQYFAMWVTRDFEALPRIFAVDCYYQECYGPAYLSLAEVQAWIEHQLRVQRVTAWSIQRLWSATDNMIFAQWSFTAVTDRITQFDGLSAVHFNLAGRIDDLREYQTTTAHDYPYHGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPF5</accession>
    <name>F9UPF5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644407.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889608.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1812"/>
    <dbReference type="EnsemblBacteria" id="CCC79094">
        <property type="protein sequence ID" value="CCC79094"/>
        <property type="gene ID" value="lp_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1812"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1530"/>
    <dbReference type="eggNOG" id="ENOG5032QT1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077106_1_0_9"/>
    <dbReference type="OMA" id="NIRYTSS"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1557-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389045" evidence="2">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="31021" checksum="842A6F268632C128" modified="2011-10-19" version="1">MNYRNLLVLPLAVLLVGCSSPTHQDSKSTSQTTTSAKATVSSTQKKAKATSSTSSRPQTAATRSSRTARERAASAANKSVTQPTATTRLAALNQQLTKTLGKQALVPQVDGLTSGSSKLNMRYSGDAANYTINYSVGQQAQPFNAAAVVDETAYATVTKTTYATTNAAAQQVGYRDNKSTAGLPTVDLGHQITAHIDAGAGQRYIMWNEGRWSLTVHANMMHEDAGVALAKQAVATFEQVYLPAPQSVGAITFDAISSGSGPLDQVIQWQAGKVVYQVKAQEMATAIKMAASMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPL2</accession>
    <name>F9UPL2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein, with LysM peptidoglycan binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101580.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889665.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1884"/>
    <dbReference type="EnsemblBacteria" id="CCC79151">
        <property type="protein sequence ID" value="CCC79151"/>
        <property type="gene ID" value="lp_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1884"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1587"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109308_0_0_9"/>
    <dbReference type="OMA" id="THGMTTD"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1613-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="210" mass="21585" checksum="09068B3ABE0167A6" modified="2011-10-19" version="1">MSQKNDNDKSQADKPWDKTFEDDRDDSGNLSRTQKRKQDSSNSTLTTVLVVLILLLALAPIGYFLVKKNSLNNPQQTEQVASSSSKKSSASVAASKSSTAASKKKAAASSKKAAAKSSSLALASSKAASSNAASSTAASSEESASTDDSSASSSSSSSESSSGTKYVTVEAGQGVYRVATNAGISVDKLLELNGLSSDATISAGQRLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPM1</accession>
    <name>F9UPM1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640600.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1893"/>
    <dbReference type="DNASU" id="1061645"/>
    <dbReference type="EnsemblBacteria" id="CCC79160">
        <property type="protein sequence ID" value="CCC79160"/>
        <property type="gene ID" value="lp_1893"/>
    </dbReference>
    <dbReference type="GeneID" id="57025486"/>
    <dbReference type="KEGG" id="lpl:lp_1893"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1596"/>
    <dbReference type="eggNOG" id="COG2996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064885_0_0_9"/>
    <dbReference type="OMA" id="GAFMDWG"/>
    <dbReference type="PhylomeDB" id="F9UPM1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1622-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CvfB_WH" evidence="3">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="33698" checksum="985D7A1C30F11E76" modified="2011-10-19" version="1">MDSIIGTVVTAKVTDENDEAYFVQIDGQTLWVDKTEPEKPLHIGGLYEGFVYENEDHHLQMTRFVPEISFDHFVWGTVVRTRHDLGVFVDVGLPNKDLVVSLDELPTISRLWPKKDDRLYVKLARDNKQRLWATLAELTDFEAIAKPYDRAQVKNTDTMATVFRLKMAGTSVITDDNHLGFVHPSEREQEPRMGQHVKARVIGFLRDGELNLSLKPRGYEEIGDDAQMLLAALQHQADHALPFWDKSDPDDIRNYFGISKSQFKRAVGNLLKQRLISQQPGEIKLLENADEQADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPN1</accession>
    <name>F9UPN1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_1908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1908"/>
    <dbReference type="EnsemblBacteria" id="CCC79170">
        <property type="protein sequence ID" value="CCC79170"/>
        <property type="gene ID" value="lp_1908"/>
    </dbReference>
    <dbReference type="GeneID" id="57025496"/>
    <dbReference type="KEGG" id="lpl:lp_1908"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1607"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627975_0_0_9"/>
    <dbReference type="OMA" id="PRINAPY"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1632-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="401" mass="46136" checksum="7C2CA184108EF84E" modified="2011-10-19" version="1">MRKRLLTTSPFLTGLKLLAILPPVGIGWLIYLSRWQWLALLKHPRQFSRHDPLLGFIVLLMGITTLNLNHHDYRSVILSVLMLFVLGNLWLLCRESTQSIAWHELRKFIIQFGLYITISGFAFHWLNQVLTLPTWLKFMLGDLLWGYAANQNRLFGSAYNPNDACCLLLIALGLLLTQLSHGSVHPFTRWPLINWFLVGLLCVGVYQTKSRTGLMIMIAILIMTTYQLCRHHRILVTTILIAGSLIVWHVFPRSASTITALQSRLTIWHNSFTVFKQAPYLGVTYFGFARHYLQLTGTYVPHAHDILLMLLASFGILGGAGFIYLVLSSGWHLTKYWHQYRTPNLRYFMMTLPIILAYGLTDFVLSSMQVLIIILLIIACWHHEQQLRPIIGPRKYQSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPP1</accession>
    <name>F9UPP1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-/manganese-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mntA</name>
        <name evidence="7" type="ordered locus">lp_1919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101590.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889694.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1919"/>
    <dbReference type="EnsemblBacteria" id="CCC79180">
        <property type="protein sequence ID" value="CCC79180"/>
        <property type="gene ID" value="lp_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1919"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1617"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_9"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="PhylomeDB" id="F9UPP1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1642-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="758" mass="81540" checksum="0BC625982526B7E5" modified="2011-10-19" version="1">MIEDLTEQQAAAKLAADGFNDVPEPTFNFFKAVVSRLWEPSAWILEGALVIEVVLGKEIQAGFIALMLVFAAVNGAIQSRRAALVLQELAHQLTPTSSVRRAGHWQLIDAKALVVGDLISLQVGSVIPADIRVLTNPIHTDESSITGESVAVIHTSGETAFAGTMVVAGETLARVLATGSHSRAGKTVSLINQNNAPGHLQRLLGKIIGYLALLDSALALIIVGIALIRHADMIQMLPFLAMLFIATIPIAMPSSFAVANSVEARELSRQRILVSELTGIQEAANLNLLLVDKTGTITTNQPQVVQFKNLSARSDHQLLRLAASATDSRHPSVVDQAIVNFAHRYQLKRLPQQEFKPFDASVGYAEALVGEAPTVVRVRIGALSRLYELTTQQPALAIDQLDLTRGRSVAVMINNVLQGVLILQDQPRPDSAAALKRIQHRGVKTIMLTGDNLKTAQAVADAVGLKSQVVSYQTFKTHSRPLAQVAGIAEVVPENKLAIVKAMQRAGYVVGMTGDGVNDAPALKQSEVGIAVDNATDLAKRSAKFVLLTGGLTNILTILDSGHRVYQRMLTWTITKLTRTVELTVLLTIGYLWLDYVPLSLNAMVLVAILNDLVTLVLGTDRTTIRHRPEQWDMPRLSKIAGVLATGWTAVGVGLIVWLHGLGLSAGQLSTSLYVYLIFSAMLTILMTRTSGPFWRGRPSRAVGLTIGLNCLLTIGLASSGWGVPAISGWLTLIVIVLVLMTGIGLTVAGDLWRRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPU3</accession>
    <name>F9UPU3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="synonym">msrA3</name>
        <name evidence="6" type="ordered locus">lp_1979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644477.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889746.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1979"/>
    <dbReference type="EnsemblBacteria" id="CCC79232">
        <property type="protein sequence ID" value="CCC79232"/>
        <property type="gene ID" value="lp_1979"/>
    </dbReference>
    <dbReference type="GeneID" id="57025557"/>
    <dbReference type="KEGG" id="lpl:lp_1979"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1672"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_1_9"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="PhylomeDB" id="F9UPU3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1696-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="176" mass="19778" checksum="9F3A1455562923AC" modified="2011-10-19" version="1">METAIFAGGCFWCMVQPFDSQPGIDSVVSGYTGGHTKNPTYEDVKAHTTGHTEAVKITFDPDIISYTELVNIYWHQTDPTDAMGQFQDRGDNYRPVIFVNGPEQRRIAEASKRALQVSERFSKPIVTAIEDAKPFYPAEARHQRFYKNNPVVFAEQEAGGRADFIAEQWADAPKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPX7</accession>
    <name>F9UPX7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Teichoic acid D-alanyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dltB</name>
        <name evidence="9" type="ordered locus">lp_2018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">O-acyltransferase that catalyzes D-alanylation of both teichoic acid and lipoteichoic acid (LTA). D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Catalyzes D-alanylation from DltC carrier protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; lipoteichoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640706.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889780.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2018"/>
    <dbReference type="EnsemblBacteria" id="CCC79266">
        <property type="protein sequence ID" value="CCC79266"/>
        <property type="gene ID" value="lp_2018"/>
    </dbReference>
    <dbReference type="GeneID" id="57025574"/>
    <dbReference type="KEGG" id="lpl:lp_2018"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1705"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_2_0_9"/>
    <dbReference type="OMA" id="CYSMYLF"/>
    <dbReference type="PhylomeDB" id="F9UPX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1728-MON"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070395">
        <property type="term" value="P:lipoteichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024024">
        <property type="entry name" value="DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500216">
        <property type="entry name" value="DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04091">
        <property type="entry name" value="LTA_dltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="404" mass="47268" checksum="34B02B36001CCEFC" modified="2011-10-19" version="1">MISFDPYGNPTYFVLLFIALLPLMIGLLYGRRSHWYESLISFIFLMLTFGGVKWRTGIALIIYLVYQITLVWLYSKYRQRPDSPNKGWVFVVSVILAIIPLAVVKITPAVAHGANSIIGFLGISYLTFKVVQMIMETRDGVIKEFHPVLFGQFLLFFPTISSGPIDRYRRFVKDYDSVPTREKYLGLVEKGVRYIFLGFLYKFILAYIFGTRMLPVVEHAALQAHGMSWALVGVMYVYSMDLFFDFAGYSLFAVGISYLMGVETPMNFNQPFKSKNIKDFWNRWHMTLSFWFRDFIYMRLVFFMMKHKVFKSRITTANVAYVINMLIMGFWHGETWYYIVYGLFHGLAMVVNDAWLRYKKKHQAQLPSNKFTEYFAIFLTFNVVCFSFLIFSGFLNTLFFGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ04</accession>
    <name>F9UQ04_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_2049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640733.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889807.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2049"/>
    <dbReference type="EnsemblBacteria" id="CCC79293">
        <property type="protein sequence ID" value="CCC79293"/>
        <property type="gene ID" value="lp_2049"/>
    </dbReference>
    <dbReference type="GeneID" id="57025599"/>
    <dbReference type="KEGG" id="lpl:lp_2049"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1734"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_0_9"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="PhylomeDB" id="F9UQ04"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1754-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="425" mass="45841" checksum="E3CAF846F6E18047" modified="2011-10-19" version="1">MIVTIITFIIVFGILVIVHEFGHFYFAKKAGILVREFSVGMGPKAVAFRRNATTYTLRFLPIGGYVRMAGVADDEDEELKPGTPVSLQIGPDGIVHSINASKKTTLFNGIPLSVTATDLEKELWIEGYENGDESEVKHYAVDHDATIVESDGTEVQIAPVDVQFQSAKLWQRMLTNFAGPMNNFILAIITFAILAFMQGGVTSTTTHVAATTADSVARTAGIQKGDQIVAVNGKKMTSAQSISLLIQDSPKQRLTLTINRAGQTKKIAVTPAAKTVSGNRIGQIGVQWATKTDTSLGAKLAYGFTGSWGITKQIFQVLGRMVTHGFSLNDLGGPVAIFATTSQAAKSGVRTVIYLLAVLSINLGIVNLLPIPALDGGKLLLNIVEGIRGKPLRVETESVITLIGFGLLMLLMILVTWNDIQRYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ99</accession>
    <name>F9UQ99_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645925.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889902.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79388">
        <property type="protein sequence ID" value="CCC79388"/>
        <property type="gene ID" value="lp_2160"/>
    </dbReference>
    <dbReference type="GeneID" id="57025694"/>
    <dbReference type="KEGG" id="lpl:lp_2160"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1829"/>
    <dbReference type="eggNOG" id="ENOG5030ADU">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186802_0_0_9"/>
    <dbReference type="OMA" id="MSNKHEI"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1849-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="67" mass="7970" checksum="E7D23EACBEA58FFD" modified="2011-10-19" version="1">MSNRFEILEEYQEANTELDHLRTLAVRQQDRSRVVTIYPHLKERVSHLSRKCEQLDMLLEAINASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQF0</accession>
    <name>F9UQF0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Competence protein/transcription factor,CoiA-like family</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">lp_2226</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101689.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2226"/>
    <dbReference type="EnsemblBacteria" id="CCC79439">
        <property type="protein sequence ID" value="CCC79439"/>
        <property type="gene ID" value="lp_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2226"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1881"/>
    <dbReference type="eggNOG" id="COG4469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057999_1_1_9"/>
    <dbReference type="OMA" id="YYLEINP"/>
    <dbReference type="PhylomeDB" id="F9UQF0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1900-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010330">
        <property type="entry name" value="CoiA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021176">
        <property type="entry name" value="Competence-induced_CoiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06054">
        <property type="entry name" value="CoiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007487">
        <property type="entry name" value="Competence-induced_CoiA_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="361" mass="41693" checksum="0D68D35CBCC4E886" modified="2011-10-19" version="1">MLIAMDAQHQLVNAATADRQIEYYCPGCVQPVRLKRGAVIVPHFAHVHATDCDAFSEGETTEHLRGKQQLATWFAASGYTVRLEAGLPEIHQRPDILVRRGTAQPLALEFQCSPLSVERLAARTQGYRQHGYQVLWLLGRPYQRQLHLNSKALKFLQYQQRWGLFLLFLDTQSTSVRLLHHVLTLDTEPLTYQTIRLDTRSQSVLHFRQLAPKINTPTLPDTHLRHYYQQLMLARLRHQRGFDALQVACYQRGGTIAQLPTWTMPTVPQLPLLSVPYLVWHAHVFFALRQQSGRLAGSQLEALIWAQLRPLLARRACLQARGTLIQQLITTMITMLSEQQVINWQKTEWQVNSDQLRWRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG6</accession>
    <name>F9UQG6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system,adenine-specific methyltransferase subunit</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2243"/>
    <dbReference type="EnsemblBacteria" id="CCC79455">
        <property type="protein sequence ID" value="CCC79455"/>
        <property type="gene ID" value="lp_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2243"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1897"/>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073534_0_0_9"/>
    <dbReference type="OMA" id="HSFAHHL"/>
    <dbReference type="PhylomeDB" id="F9UQG6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1940-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_methylase_A-5"/>
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        <property type="entry name" value="S-AdoMet-dep_Ade-MeTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026567">
        <property type="entry name" value="Adenine_mtase_bact_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="37175" checksum="0D961C09E42CEB98" modified="2011-10-19" version="1">MAQAETETLFQVLDQSVQVLMQQLSVSYVDALIETGDNLLSQSVHVEDGKPNPEQTAALTKLYQTIDLKQLDAETIRRALQLALLKAIHNDHVDPNHQMTPDSIGLLTAYLIAKLVGSTTDLSILDIAVGTGNLLTTVINQLQTDRPRPIQGYGVDNDDNQLAIAAMSMDLQRSAVELFHQDAIDPLVMPKTTVVIGDLPVGYYPLDDRVQGFQTKATNGHSYIHHLMMEQAMAHLLPGGWGVFLVPTTIFQSQESQGLLKWMSTAAYLQGLLNLPTNLFLDEKSRKSIVVLQKHGQRAHQAGKVLLGDFPSFEDQRAFQAFTAQIDAWVDQNIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQM6</accession>
    <name>F9UQM6_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB1</name>
        <name evidence="2" type="synonym">mreB</name>
        <name evidence="3" type="ordered locus">lp_2319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644642.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890029.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2319"/>
    <dbReference type="EnsemblBacteria" id="CCC79515">
        <property type="protein sequence ID" value="CCC79515"/>
        <property type="gene ID" value="lp_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2319"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1960"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_9"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="PhylomeDB" id="F9UQM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1999-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="334" mass="35145" checksum="6AA4D57C44EB7202" modified="2011-10-19" version="1">MFGFGTKNIGIDLGTANTIVYVDGKGIVLREPSVVAKNTKTGEIVSVGSEARDMIGRTPASIVAIRPMKDGVIADYDTTVAMMKYFIQKTLGRSNGKPYVMVCVPSGVTEVEKRAVIDATRVAGARDAYVIEEPFAAAIGAGLPVMDPTGSMVVDIGGGTTDVATISLGGIVSSRSIRMAGDKIDDSIIYHVRQKFNLLIGERTAEQLKIDCGSASLEAAEDLEGSTIRGRDLLSGLPKTVEISSVDVSEAIQEVVSEIISAIKETLEETSPEIASDVIDHGIVLTGGGALLKNLSEVIADETKVPVFIANEPLDCVAVGTGESLKSIDVMKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU1</accession>
    <name>F9UQU1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prophage P2a protein 56, lysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">lp_2401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890094.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2401"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79580">
        <property type="protein sequence ID" value="CCC79580"/>
        <property type="gene ID" value="lp_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2401"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2027"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709497_0_0_9"/>
    <dbReference type="OMA" id="INGYHFA"/>
    <dbReference type="PhylomeDB" id="F9UQU1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2065-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08460">
        <property type="entry name" value="SH3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388958" evidence="4">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC79580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="384" mass="41772" checksum="90F970D926BAAB98" modified="2011-10-19" version="1">MKFKNKLALTGAATMAALFLGLNASAARMDMVDVSNNNGYMSTAEYVSMRNEFGVKAVTVKISEGGTYKDPYAASNIANVQAAGMYINGYHFARYATKSQAIAEADFAGRTAKSAGLPVGAVLATDVESQEANNQSKATNDRNNAAFMQEIQKFGYRADIYTSGSWANNKMTIKGKTGWIAGYPFVPAGKKWYTNNNAWQWSGSAHCRISYGGFDVSQLYTDYYTAGQKSTVKPTNKAAVKANNRKANKHIYRPSASAKWVKESKTYTLKTAVKLRTGASTSSSVITILPAGTTVKTDQAIIQGGYRWVRQPRFNGYAYLATGPASSTLEYVKSGASHTYYTVKSGDSWWAIAQRNGLNMTTLASQNGKTIYTTIYPGQRLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQW1</accession>
    <name>F9UQW1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 36 terminase large subunit TerL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2421"/>
    <dbReference type="EnsemblBacteria" id="CCC79600">
        <property type="protein sequence ID" value="CCC79600"/>
        <property type="gene ID" value="lp_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2421"/>
    <dbReference type="eggNOG" id="COG1783">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035697_0_0_9"/>
    <dbReference type="OMA" id="KANGYER"/>
    <dbReference type="PhylomeDB" id="F9UQW1"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035413">
        <property type="entry name" value="Terminase_L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17288">
        <property type="entry name" value="Terminase_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_3C" evidence="1">
        <location>
            <begin position="65"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="233" mass="26481" checksum="E67B5CB2DBE1B8FF" modified="2011-10-19" version="1">MSSSLTNISSDSIGLYQTNPRRAKTVVDGDWGVAEGLVFEDNIEQIEFNTMDKIQECGQTGFGLDYGFGNDPNAFVAVAVDVRNKQLWVYDEMYTYHQTTPHVAEWLKANGYERARIYADSANPERTAQLNDLGIVNADSVVKTPIEAGIDQLWQYQIHVHPKCKNLWRELNSYVFDSDRMGNTLSKPKDQDNHAIDALRYAVRQYMGDYDGSLGVKWDEQYAIGRQMGVNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR08</accession>
    <name>F9UR08_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage P2b protein 7, DNA replication</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101798.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890161.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2474"/>
    <dbReference type="EnsemblBacteria" id="CCC79647">
        <property type="protein sequence ID" value="CCC79647"/>
        <property type="gene ID" value="lp_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2474"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2085"/>
    <dbReference type="eggNOG" id="COG5519">
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    <dbReference type="HOGENOM" id="CLU_082084_0_0_9"/>
    <dbReference type="OMA" id="NWTSEHA"/>
    <dbReference type="PhylomeDB" id="F9UR08"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2139-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08708">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PriCT_1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="266" mass="29850" checksum="2613CD74A1BC070B" modified="2011-10-19" version="1">MREFSTLDKAIELAQQGYSVYPLIENMKNPPKGVAGYKDATIDQGTIFAWFENHPNYNLGLRLDLSDLLVVDVDMHDQTKNGRNSLAQLFKQGQTLPNDTYIERTANGGVHYFLKYAGAKVRKVDVWPGIDLLSDFTVIAPSEINGKPYEPLDDRTLTDIKPAPQWLVDKLAGQKVNWTSEHAYTTRQKKYTGRLLDEMVTGTTQGNRNAWLTKIAGRMFGVGAAPKTVYNMLSVINDSFVDPALPSKEVNVIFRSILKRESKGVH</sequence>
</entry>
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    <accession>F9UR14</accession>
    <name>F9UR14_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642773.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890167.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79653">
        <property type="protein sequence ID" value="CCC79653"/>
        <property type="gene ID" value="lp_2482"/>
    </dbReference>
    <dbReference type="GeneID" id="57025925"/>
    <dbReference type="GeneID" id="66450207"/>
    <dbReference type="KEGG" id="lpl:lp_2482"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2089"/>
    <dbReference type="eggNOG" id="ENOG5030ABZ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188348_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR14"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2145-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="77" mass="8985" checksum="6ADA2046FA77AF39" modified="2011-10-19" version="1">MLLVYKDVFGIDHNDCHIVQTRHEFNRIFIIENEVGSRFTCIKDDAPLEKKMSGHWKYAKASDAPKNYAVPYKAQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR21</accession>
    <name>F9UR21_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">lp_2488b</name>
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890174.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2488b"/>
    <dbReference type="EnsemblBacteria" id="CCC79660">
        <property type="protein sequence ID" value="CCC79660"/>
        <property type="gene ID" value="lp_2488b"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2488b"/>
    <dbReference type="HOGENOM" id="CLU_3169537_0_0_9"/>
    <dbReference type="PhylomeDB" id="F9UR21"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2152-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="43" mass="4687" checksum="F1874881DF859AE4" modified="2011-10-19" version="1">MSFFNDFHVLPGTHTSSYTSSVSNDIFGGLHSFILNVIKAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR41</accession>
    <name>F9UR41_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate transporter, major facilitator superfamily (MFS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_2514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101811.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890194.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2514"/>
    <dbReference type="EnsemblBacteria" id="CCC79680">
        <property type="protein sequence ID" value="CCC79680"/>
        <property type="gene ID" value="lp_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2514"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2117"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_9"/>
    <dbReference type="OMA" id="EIFPTKD"/>
    <dbReference type="PhylomeDB" id="F9UR41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2173-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="36"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="11"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101844.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="RefSeq" id="YP_004890258.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="EnsemblBacteria" id="CCC79744">
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        <property type="gene ID" value="lp_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2597"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2180"/>
    <dbReference type="eggNOG" id="COG1349">
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    <dbReference type="OMA" id="ANYNCDT"/>
    <dbReference type="PhylomeDB" id="F9URA5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2235-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLACR"/>
    </dbReference>
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        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="251" mass="28305" checksum="3CD072D38078B0D0" modified="2011-10-19" version="1">MNQRNEQLLEIVNQRKKVEVNELASLLEVSKVTIRKDLTELENRGLLQRQHGFAIINNPNNLNFRLAQNYDIKHKIAEAAATLVQDNETIMIESGSTCALLAEELGKSGKHVTIITISFFIANYVRNYDNITVYTLGGQYQSDAQVAVGPLTKTMLANFHTEKLFLGIDGFDRNYGFYGNDIMRTDTVHAMADNADKTCILTDSSKFELTSTVHQLPFQQVDTVITDNQLSKEAHRVLNFQQIKVQTVATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9URD4</accession>
    <name>F9URD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101861.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890287.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79773">
        <property type="protein sequence ID" value="CCC79773"/>
        <property type="gene ID" value="lp_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2636"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2211"/>
    <dbReference type="eggNOG" id="ENOG50309TP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287499_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2264-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="220" mass="23098" checksum="099EAA0F9706095A" modified="2011-10-19" version="1">MKKMLVSSAVIAGIIALGGGYYLEADHQSSQSRVSETQSVVSKTKAKKDASSSAKSTKQSTAAKSSSTKASSVSTTSANESQSEANATTSQGSKTATAASSHGHSNTTATSQTTTGQSASATSSSTSGQQTTNPQQLTASQINDWAWQQVAKDYQQTTANKQNFVFNQYQSGGLVYVEVYENTNADVAHLAGRFRINAQGQLEQQQLAKGNVWQVVATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URE5</accession>
    <name>F9URE5_LACPL</name>
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        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645906.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890298.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2652"/>
    <dbReference type="EnsemblBacteria" id="CCC79784">
        <property type="protein sequence ID" value="CCC79784"/>
        <property type="gene ID" value="lp_2652"/>
    </dbReference>
    <dbReference type="GeneID" id="57026044"/>
    <dbReference type="KEGG" id="lpl:lp_2652"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2222"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_9"/>
    <dbReference type="OMA" id="HLRFGNP"/>
    <dbReference type="PhylomeDB" id="F9URE5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2275-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
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    </dbReference>
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        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="153" mass="16918" checksum="62D3C917C34AC038" modified="2011-10-19" version="1">MLQQYQNILVPVDGSKATDEVLRRGIEVAKRNKTHLDILNVLEVNQFSDTYGGAVSGDVIYKLSEDVQKRLEELKQQTIDAGVTDVDVHVRFGNPKTVIAREFPADHHNELIMIGSTGLSAVERLMVGSVTTYVSRNAICDVLIVKPAAKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9URG5</accession>
    <name>F9URG5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Medium chain degydrogenase/reductase, MDR family</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003645894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890318.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9URG5"/>
    <dbReference type="STRING" id="220668.lp_2677"/>
    <dbReference type="EnsemblBacteria" id="CCC79804">
        <property type="protein sequence ID" value="CCC79804"/>
        <property type="gene ID" value="lp_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2677"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2243"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="IPALTAW"/>
    <dbReference type="PhylomeDB" id="F9URG5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2295-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="314" mass="33182" checksum="4088EDF2D38D8AC9" modified="2011-10-19" version="1">MKTIAINQYGSADEFTMVDMPTTEPQADEVQVAIHAFSLNPMDIAGRMGALSSPFTDLWAFPLVLGWDFAGVITKMGKAVTGFNIGDAVFGSAAPAHAANNGTYGEFITVNTKELAHLPAGLSFDQAAALPIAGLTAYYGMKHNLKLQSGQKILVQGGAGGVGLFAIQIAKAFGAYVATTASANHRDLLTRLGADEVIDYHETDPAAVLHDYDAVFDTVGDIDTGLKVLKADGQLATIAGQPTDEQQHDQQKKVAFQFTQGSSQDLADLAQLVVSGQVKLTVATLPFSVANVIKGHRSIESRHTTGKIVIHVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URR3</accession>
    <name>F9URR3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101920.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890416.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2797"/>
    <dbReference type="EnsemblBacteria" id="CCC79902">
        <property type="protein sequence ID" value="CCC79902"/>
        <property type="gene ID" value="lp_2797"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2797"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2342"/>
    <dbReference type="eggNOG" id="ENOG5030AD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2666528_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2393-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="73" mass="8758" checksum="F2FC266ED9090B21" modified="2011-10-19" version="1">MQWRSFWRHTRTIFETLVIYFLLIQGPYDLWIGKVGYRLSSYLIDIVGITVLLVIVELVYNAIRQIVVKRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT2</accession>
    <name>F9URT2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642106.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890435.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79921">
        <property type="protein sequence ID" value="CCC79921"/>
        <property type="gene ID" value="lp_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2824"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2362"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091606_2_0_9"/>
    <dbReference type="OMA" id="INIVGGH"/>
    <dbReference type="PhylomeDB" id="F9URT2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2418-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="183" mass="19534" checksum="EB7C6DBD2BFFFC09" modified="2011-10-19" version="1">MKRIKTRAITLLALCIALNIVGSNIALMLKLPIYLDSIGTVLAAAVFGPLGGMLAGGATGVIVGATTDLYSLFFMPVQLLTGLVAGLLYRRIKPGTWRSNWWLAGVISLPGTLLSTAITVILFHGITSSGSSMLVQLLLGTGMGKTMAVFLIQVGTDYLDRFITVYVVALVYRALRYKLPQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9URU5</accession>
    <name>F9URU5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_2842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642119.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890448.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2842"/>
    <dbReference type="EnsemblBacteria" id="CCC79934">
        <property type="protein sequence ID" value="CCC79934"/>
        <property type="gene ID" value="lp_2842"/>
    </dbReference>
    <dbReference type="GeneID" id="57026199"/>
    <dbReference type="KEGG" id="lpl:lp_2842"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2376"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="OMA" id="IEGPCHH"/>
    <dbReference type="PhylomeDB" id="F9URU5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2431-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="275" mass="30725" checksum="DC23F85CB9427931" modified="2011-10-19" version="1">MFKQLETFCAVYETRNFSHAAEQLFISQPTVSTQIKQLEADLQTTLLTRNGRQEIVPTASGQLLYQQAQKLLTTWAATKTAVQSPRHLVKVPCRIGASHTTGRLILPTLLANLSAVSDRFDFQVTLANSAEILTAMSQHKLDFGLVEKPLVTDQLNRLPFGHDELVHAGDFASPLWLLREPNSGVRHYTNAFLKARNIQPAQVMVIHSNQIIADLLAHGIGQTIISRHVLSNEIPIEQLSAHYQRQFFLLTNTQPAAALRPVQTAITQYLTTWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV7</accession>
    <name>F9URV7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="4">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapE2</name>
        <name evidence="4" type="ordered locus">lp_2855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642132.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890460.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2855"/>
    <dbReference type="EnsemblBacteria" id="CCC79946">
        <property type="protein sequence ID" value="CCC79946"/>
        <property type="gene ID" value="lp_2855"/>
    </dbReference>
    <dbReference type="GeneID" id="57026211"/>
    <dbReference type="KEGG" id="lpl:lp_2855"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2388"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_9"/>
    <dbReference type="PhylomeDB" id="F9URV7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2443-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="213"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="420" mass="45370" checksum="79E6C9379EB7CD46" modified="2011-10-19" version="1">MNGMAETAQLEAAVQALSDIVKMNTVNNHEQLVADYLVTLLKQHGIEAQSIEYAPGRVNLVAEIGDGHGPVVALDGHEDTVALGDADKWHTDPLAATIKDNRLYGRGVTDMKAGLMAEVFAMIALHDQDAPLHGTVRLLATVGEEVDHLGAEQLTELGYADDIQTLICAEPSGADKQLLLTKSIQAMLGVDGDTAQRMADANPTTEQHFIELAHKGSLTYTIKAQGVAAHSSMPAIGQNAIDMLMTYYQKQTAYFDSFKTIVNPVLGPTVPVVTLISGGEQVNTVPASAEMSVKIRTIPELRNDRLIKDLEAIIAECNADGANLTMDIASSFYPVHTPEDSQLVQLAKKVGEQVLQQRLPYFGAPGGTDASSYIVKSPDMQVIVFGPGNITAHQVNEYVDLDMYGRFIEIYQKMITELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9URX7</accession>
    <name>F9URX7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltose O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">maa</name>
        <name evidence="3" type="ordered locus">lp_2878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.79" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2878"/>
    <dbReference type="EnsemblBacteria" id="CCC79966">
        <property type="protein sequence ID" value="CCC79966"/>
        <property type="gene ID" value="lp_2878"/>
    </dbReference>
    <dbReference type="GeneID" id="57026244"/>
    <dbReference type="KEGG" id="lpl:lp_2878"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2409"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_9"/>
    <dbReference type="OMA" id="FYSGTHP"/>
    <dbReference type="PhylomeDB" id="F9URX7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2463-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC79966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="20853" checksum="6BCA1F5B689E7C66" modified="2011-10-19" version="1">MEIDNDPAYQQMINGELYLESPILQQRRRDVRTKLMQYNQIADNDERNTKMKSLLRSAGDRFFVEPTFEFSYGVNIRIGNHFYANHGVTLCDEGLITIGNDCKFGPKVGLYTPAHPLDPTVRRTEAERTAPITIGNDVWIGGSAVILPGVTLGNNVIVGAGAVVTHSFPDNVIVVGNPARVLKQNAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9URY6</accession>
    <name>F9URY6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101956.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890489.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2890"/>
    <dbReference type="EnsemblBacteria" id="CCC79975">
        <property type="protein sequence ID" value="CCC79975"/>
        <property type="gene ID" value="lp_2890"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2890"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2418"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_9"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="PhylomeDB" id="F9URY6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2472-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="342" mass="38350" checksum="3D4E88DFB24B52B1" modified="2011-10-19" version="1">MQYRQLGTSDLKVSSIALGCMGFGAGTGTALNQRSWAVGQTQANQVLDRAISLGINFFDTAPVYQAGASERVLGQGLKKFQRDQLVLATKFTNRTTQEIENHVSGREHVLRSLDQSLQNLQTDYVDLYIYHIWDWLTPMAEIMAGLNEAVQAGKVRYIGISNAYSWQIAQINALAVRYGYPQFVSIQSHYNLVYREDERELFSYAHENDLATTPYSPLASGRLAHPFGTQTTRRQQDTFADTKYQATSEMDQPIIDRVEELAHQHHVSMAAINLAWLQQRVTAPIIGATKPHHLDAVAEAAGLALTASEIQYLETPYQPHDLEGVMALNRSRTNNWNQYSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9URZ1</accession>
    <name>F9URZ1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101960.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890494.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79980">
        <property type="protein sequence ID" value="CCC79980"/>
        <property type="gene ID" value="lp_2899"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2899"/>
    <dbReference type="HOGENOM" id="CLU_2666537_0_0_9"/>
    <dbReference type="OMA" id="EYCANVL"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2476-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="75" mass="9040" checksum="12B315F1D9A7BAA1" modified="2011-10-19" version="1">MMAVFKSSFKQSMIVFGISVIYFFVLHGGYDFLTQYKYWFTEYCANVLGISIIYFVMSLAFNYVIIIWKLYFRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F9US62</accession>
    <name>F9US62_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hpk1</name>
        <name evidence="15" type="ordered locus">lp_0037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641656.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888123.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0037"/>
    <dbReference type="EnsemblBacteria" id="CCC77609">
        <property type="protein sequence ID" value="CCC77609"/>
        <property type="gene ID" value="lp_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="57026895"/>
    <dbReference type="GeneID" id="66448188"/>
    <dbReference type="KEGG" id="lpl:lp_0037"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.31"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_9"/>
    <dbReference type="OMA" id="LTFWAVN"/>
    <dbReference type="PhylomeDB" id="F9US62"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-31-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="388"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="624" mass="70499" checksum="9B4DE660BEF4A4D3" modified="2011-10-19" version="1">MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDNSLSEQLTVSSTRKANGQIKTILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTDRNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAGNSSQLVGVLYVRANMKSVYSTINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDDELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDFMDVTAEKAIGNSILDILKIRDDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESGFISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSLRSYIEALSDGAWKDPEVAPGFLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNPAKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISISDQGLGIPRADLGHVFDRFFRVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKGSTFYISLPYEPYEEEDLWDDDSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9US72</accession>
    <name>F9US72_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_0052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646169.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888133.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0052"/>
    <dbReference type="EnsemblBacteria" id="CCC77619">
        <property type="protein sequence ID" value="CCC77619"/>
        <property type="gene ID" value="lp_0052"/>
    </dbReference>
    <dbReference type="GeneID" id="66448200"/>
    <dbReference type="KEGG" id="lpl:lp_0052"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.41"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_5_0_9"/>
    <dbReference type="OMA" id="PHTWEII"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-41-MON"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017543">
        <property type="entry name" value="6-PTP_synth_prd_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03112">
        <property type="entry name" value="6_pyr_pter_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="122" mass="13960" checksum="6CFEF5E63D68A183" modified="2011-10-19" version="1">MPTKQRTYKIKSYVNASHAVRWATGSGKKHTHTWEIVCELHTVDAMVAFYDIEKNLHQALDELSGKFLNDLPEFKTVNPTVENVTEYLFTKIDKTLRDNGAQLLRIEVSDSPTRAYCISVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD8</accession>
    <name>F9USD8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbg6</name>
        <name evidence="3" type="ordered locus">lp_3011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890582.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9USD8"/>
    <dbReference type="STRING" id="220668.lp_3011"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80068">
        <property type="protein sequence ID" value="CCC80068"/>
        <property type="gene ID" value="lp_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3011"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2514"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_0_2_9"/>
    <dbReference type="OMA" id="HFDMPLH"/>
    <dbReference type="PhylomeDB" id="F9USD8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2562-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="460" mass="53362" checksum="F69FE51BF093D170" modified="2011-10-19" version="1">MDKERQMPKDFFWGNSVSSMQTEGAWDEDGKGRSVYDVRPATATTSDWHDAIDEYHRYEEDLDLMKDLHLNMYRIQISWSRVVPDGDGEFNAAGIAFYDRLVDAMLARGITPMICLYHFDMPLALAENENGFMSRHTVDAFVRFGEKMIAHFADRVKYWIVFNEHNLYFTDEVFNISGYTKGDQSVNDLYRIFHHTMLAHARLDDFVHQNYDDVKIGGMLAYTPVYPETAKPIDIMAARKSDEFLNNNLNDAYVHGHYSPEVLRYVEQQGIDYDLQPGDEAIIGKMKADFLAFSYYRSTVINGDKIPVNAVPNRYLNYSFEANRFLQANEWGWAIDPLGFRNLITKLYDQYEVPVFPIENGIGLREHWDGQHMIEDDERITYHEEHIKAMKDAMLIDGAKVLGYLGWGLIDIPSSHADIEKRYGVVYVNRSNHDLKDLKRVPKKSYYWLQGVLAKNGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USM3</accession>
    <name>F9USM3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642355.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890667.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3110"/>
    <dbReference type="EnsemblBacteria" id="CCC80153">
        <property type="protein sequence ID" value="CCC80153"/>
        <property type="gene ID" value="lp_3110"/>
    </dbReference>
    <dbReference type="GeneID" id="57026419"/>
    <dbReference type="KEGG" id="lpl:lp_3110"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2599"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_9"/>
    <dbReference type="OMA" id="ANAIMYA"/>
    <dbReference type="PhylomeDB" id="F9USM3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2646-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="26566" checksum="5CCD1AFE931EC4E6" modified="2011-10-19" version="1">MSIKGKVVVITGASSGIGAATAKLLAAKGAKVVLGARREERLQALSQAIGDNAVYQVTDVTDRQQVRALIDLAVSKFGRVDVLYNNAGTMPQGNLSDREYDKWQMMLNVNIMGVLNGIGEVLPIMQKQHDGLIIATDSVAGHVVYPASAVYNGTKYAVRAIMEGLRQEEKEHGIRSTIVSPGAVRTELVNTIGNTQIQAGISELMNADDRQGLALNPEDIANAVLFAIDQPKHVAISEVLVRPAQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9USP0</accession>
    <name>F9USP0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642372.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890684.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3130"/>
    <dbReference type="EnsemblBacteria" id="CCC80170">
        <property type="protein sequence ID" value="CCC80170"/>
        <property type="gene ID" value="lp_3130"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3130"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2618"/>
    <dbReference type="HOGENOM" id="CLU_1048848_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2663-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="265" mass="30177" checksum="18068D5D4FE4A414" modified="2011-10-19" version="1">MRKKKYISQRTRATHTYSFYRQRRNDPNWRADYLAARVCRQRHILISLIIILVLILIGVIGYRNRVVTLLNGSETTSQVTTVKNASGEDSIKDFTKQSVSNEQTKTIDNVQKTVTISDYQRYSAYSGEYGSETQTCSLDFATGELMTTGPQKQQVFYFDKVMLHPDKSLVINMHGNYHYNAYDGKGERYRLVHLSVLFAPRDQKITQNWQTGKSLEDGTNTAVNRFSIALSNDGGKVFQMSPAYTAFETNQTKGDTLAVIYSEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9USR5</accession>
    <name>F9USR5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100874.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888160.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0082"/>
    <dbReference type="DNASU" id="1061260"/>
    <dbReference type="EnsemblBacteria" id="CCC77646">
        <property type="protein sequence ID" value="CCC77646"/>
        <property type="gene ID" value="lp_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0082"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.68"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_9"/>
    <dbReference type="OMA" id="PVVPGWD"/>
    <dbReference type="PhylomeDB" id="F9USR5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-68-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="334" mass="36216" checksum="5E3294BA474ABFE6" modified="2011-10-19" version="1">MKAAIITKYKQITPMVTEVPVPTIAPTDVLVKIVAASVNPIDLKTKDGDLRLLLQYTMPLIMGSDFAGVITAVGDQVPDFKVGDAVYGRAPKDRIGTFAEFIAIDHQAIALKPANLNFEEAAAIPLVGLTSYQALHDIMNIQPGQKVFIPGGSGGIGIIAIQLAKYFGAYVATTTSAKHFDLVQSLGADKIIDYHQQDFTDVLSHYDAVLDTRGGQSLEAAFQIIKPGGQIVSIAGLPNARFGKDYGLPIWKQWLLGLATRKLSRLEQQAQATYSFLFMQPSGQQLVRLRQLIEQGVIKPVVDRIIPLTDINAALEYSHSGHTTGKIIISIQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9USS0</accession>
    <name>F9USS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein, FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2007-11" db="PDB data bank">
            <title>Crystal structure of Pyridoxamine 5'-phosphate oxidase-like protein (NP_783940.1) from Lactobacillus plantarum at 1.55 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641701.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888165.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="3BA3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A/B=1-144"/>
    </dbReference>
    <dbReference type="PDBsum" id="3BA3"/>
    <dbReference type="SMR" id="F9USS0"/>
    <dbReference type="STRING" id="220668.lp_0091"/>
    <dbReference type="DNASU" id="1061380"/>
    <dbReference type="EnsemblBacteria" id="CCC77651">
        <property type="protein sequence ID" value="CCC77651"/>
        <property type="gene ID" value="lp_0091"/>
    </dbReference>
    <dbReference type="GeneID" id="57026936"/>
    <dbReference type="GeneID" id="66448234"/>
    <dbReference type="KEGG" id="lpl:lp_0091"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.74"/>
    <dbReference type="eggNOG" id="ENOG5030W3A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149966_0_0_9"/>
    <dbReference type="OMA" id="CENILYF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-73-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3BA3"/>
        </source>
    </evidence>
    <sequence length="144" mass="16044" checksum="A943270D51BB603E" modified="2011-10-19" version="1">MDISLLKQVVQSTNKIALSTAVNNEADVKIVNFVWYEAQPDTLYFSSVKTSPALKVYDQNPDIAFITIPNDGTAGNPYLRAQHVKLQRSTKTMTDLLPQYLETVPNYQQVWDAIGSTLVVFELKLTDLFVDAGVGGEKQTLTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT41</accession>
    <name>F9UT41_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk</name>
        <name evidence="3" type="ordered locus">lp_0242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100930.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888286.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0242"/>
    <dbReference type="EnsemblBacteria" id="CCC77772">
        <property type="protein sequence ID" value="CCC77772"/>
        <property type="gene ID" value="lp_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="57027062"/>
    <dbReference type="KEGG" id="lpl:lp_0242"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.199"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_9"/>
    <dbReference type="OMA" id="ALWFGEQ"/>
    <dbReference type="PhylomeDB" id="F9UT41"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-194-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="154" mass="16982" checksum="F162E0BE945B329A" modified="2011-10-19" version="1">MANSEKTLVLVKPDGVSEGHIGEVITRLERKGYQIAALKVIKATAEQLQQHYSEKVGKPYFKEIETYMMEGPLVAIIVSGTGVVKAVHRLAGSTRPAEAQPGTIRGDFSHEYPDGILRNVIHTSDSRENAHHEIAIWFPELAVKARKADNKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT45</accession>
    <name>F9UT45_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts3C</name>
        <name evidence="11" type="ordered locus">lp_0247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100933.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888290.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0247"/>
    <dbReference type="EnsemblBacteria" id="CCC77776">
        <property type="protein sequence ID" value="CCC77776"/>
        <property type="gene ID" value="lp_0247"/>
    </dbReference>
    <dbReference type="GeneID" id="57027066"/>
    <dbReference type="KEGG" id="lpl:lp_0247"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.203"/>
    <dbReference type="eggNOG" id="COG1455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029688_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UT45"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-198-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="425" mass="46277" checksum="93C5106181988F73" modified="2011-10-19" version="1">MDNFINMLNAKVLPVANKVGTQRHMTAIRKGIISTLPLTIVGSFFTILNNMPIEAVANFLAPYAEILDVPFRYTVGILALYATFGIASSLAESYQLDKLTNGVLAVLAFLVSTAVPVHVTKNVSGVISSGRYINIANLSASSLFGSIITGLLTVEIFRYLKNRNITIKMPEGVPPEVSNSFVALVPAAVILVLFWGIRYLLDFNISSFLSTLLMPLKGVLVGNSLFGGLLTIFLITGFWTLGIHGAAIMDPVIRPFWEMSIAQNMSEFTSGTSAHNLSTIFTEQFLQWFIWIGGAGGTLALVVLFMFSKSTYLRDLGKLSLLPGLFNINEPIIFGAPIVMNPILGIPFIIGPLITGSLAYVLTITGVVPMMMARLPFTVPGPLGAFISTNWSVPALILSCVNFVIDLVIYYPFFKVFEKQQLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT47</accession>
    <name>F9UT47_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100935.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888292.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0249"/>
    <dbReference type="EnsemblBacteria" id="CCC77778">
        <property type="protein sequence ID" value="CCC77778"/>
        <property type="gene ID" value="lp_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0249"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.205"/>
    <dbReference type="eggNOG" id="COG3589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065324_1_0_9"/>
    <dbReference type="OMA" id="MSNDVEY"/>
    <dbReference type="PhylomeDB" id="F9UT47"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-200-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="MupG"/>
    </dbReference>
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        <property type="entry name" value="MupG_C"/>
    </dbReference>
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        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="247"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="364" mass="41487" checksum="2795530CBBDFC610" modified="2011-10-19" version="1">MTKRTLGISLYPDHSVFERDQAYLKVAASYGFTRLFVSMLEVQDGKERVTEKYQRIIQSAHQRGFTTTLDVSPNIFDQLGVSYQDLSYFASLGADAIRLDAGFDGHQEAWLSYNSQGLNLELNMSNDVEYLSNILSYSANRPFLYGCHNFYPQRGTGLPFDFFVACSRRFKRAGIETAAFVTAPGATIGPWDINDGLPTLEMHRDWPLQVQVQHLFSTGLIDSVLIGNAYAKQEDLQKLGALNRYQITFAVTPSADIQPVERQILLDNLHERRGDINDITIRSTEVRKRYHDFNRVNDDRHTFQRGDVVIGNEQFGKYQHELQIVQQPHTDTRKNLVATINPDQLVLLDAIGPWTKFSFEVAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT49</accession>
    <name>F9UT49_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-seryl-tRNA(Sec) selenium transferase-related protein, pyridoxal phosphate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100937.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888294.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0251"/>
    <dbReference type="DNASU" id="1061210"/>
    <dbReference type="EnsemblBacteria" id="CCC77780">
        <property type="protein sequence ID" value="CCC77780"/>
        <property type="gene ID" value="lp_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="57027070"/>
    <dbReference type="KEGG" id="lpl:lp_0251"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.207"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040896_1_0_9"/>
    <dbReference type="OMA" id="TCAIEHY"/>
    <dbReference type="PhylomeDB" id="F9UT49"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-202-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006337">
        <property type="entry name" value="DgaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01437">
        <property type="entry name" value="selA_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="366" mass="39615" checksum="CA7958E7974A9616" modified="2011-10-19" version="1">MDIYEKYGLKPVINADGKMTILGVSQVSDQVAAAQKQGAQNFFEMAELTVQTGRYLADLIGSEDALIVNSASAGIAQVLAGIIGRGNAYHVTHPYTTQITQREVIMPLGHDVDYGAPVDVMLAVAGAQPVLAGYANRCTAEQLAMQITPQTVAILYIKSHHTVQKSMLTIADALQVAHDHHLPLVLDAAAEGDLRRYLQLGVDVVIYSGAKAISGPASGLVLGRQTYVEWARQQNYGIGRAMKIGKENILGLVAAVEQYLTTGPESGASMKARLAPFIAELQTLPNVQVEMVQDGAGRDIFRASVRIAEAAKICQALRQGRPAIYPREYRVNEGLIEFDIRALTSAEMTQIVERLRTIIEEESTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT79</accession>
    <name>F9UT79_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80197.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC80197">
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        <property type="gene ID" value="lp_3165"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3165"/>
    <dbReference type="eggNOG" id="COG2801">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="54" mass="6511" checksum="02930228FA16BFFC" modified="2011-10-19" version="1">MRENNLLCQAFNRRTKKYNSYKGTVGTVDHNRLNRRFKTDCPFQKIVTDVTEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH6</accession>
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        <submittedName>
            <fullName evidence="2">Transcription regulator, ArsR family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">lp_3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890808.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3287"/>
    <dbReference type="EnsemblBacteria" id="CCC80294">
        <property type="protein sequence ID" value="CCC80294"/>
        <property type="gene ID" value="lp_3287"/>
    </dbReference>
    <dbReference type="GeneID" id="57026557"/>
    <dbReference type="GeneID" id="66450822"/>
    <dbReference type="KEGG" id="lpl:lp_3287"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2744"/>
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    <dbReference type="HOGENOM" id="CLU_097806_7_3_9"/>
    <dbReference type="OMA" id="YHVEHLR"/>
    <dbReference type="PhylomeDB" id="F9UTH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2782-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="114" mass="12616" checksum="3336501D1DE6A93A" modified="2011-10-19" version="1">MENEMDHEMIVKRLAELMPPTDELSRITAIFKALGDPTRARIIYALAVSKLSVGELATGLALTQSNVSHQLTVLKQLKLVVGTRNGRNVHYQLADKHIISIFQQVAAHAEEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ6</accession>
    <name>F9UTQ6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound protease, CAAX family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_0301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0177 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888340.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0301"/>
    <dbReference type="EnsemblBacteria" id="CCC77826">
        <property type="protein sequence ID" value="CCC77826"/>
        <property type="gene ID" value="lp_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="66448393"/>
    <dbReference type="KEGG" id="lpl:lp_0301"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.254"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141434_0_0_9"/>
    <dbReference type="OMA" id="HTVNDFF"/>
    <dbReference type="PhylomeDB" id="F9UTQ6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-248-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:CAAX-box protein processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rce1-like"/>
    </dbReference>
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        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="239" mass="26666" checksum="D0F2D7836C8123A0" modified="2011-10-19" version="1">MRHETKLVITLWGGMLGSMLLIGLIFQLPRLTQLPSSLTTGVEELFFLAIALILNRDWLRQTLKFGVSATWRRQIRPIIPTLIVAALIGLYTLATAQQLTNTLTLLFVAILISLFEETFFRGMLFQASQSTLGVGRAAVFTSILFSLTHLINLGHQTLSLTLLQLGFTFVLGLLLCLITAQTTSLLWPLLIHTVNDFFSMMAPPINLPGITTTSFQIIEIAVIILLILPILRQNHQWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTS1</accession>
    <name>F9UTS1_LACPL</name>
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        <submittedName>
            <fullName evidence="7">Spermidine/putrescine ABC transporter, permease protein</fullName>
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        <name evidence="7" type="primary">potB</name>
        <name evidence="7" type="ordered locus">lp_0317</name>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888355.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0317"/>
    <dbReference type="EnsemblBacteria" id="CCC77841">
        <property type="protein sequence ID" value="CCC77841"/>
        <property type="gene ID" value="lp_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0317"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.269"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_9"/>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="PhylomeDB" id="F9UTS1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-263-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="277" mass="31361" checksum="5A5A9136B0BDF56F" modified="2011-10-19" version="1">MQPKQRLSRNTAYFIPYMLWIILFVIAPVLLLIYQSFFNINGQFTLGNYQTYFSSNTYLMMTLNSVWYAFLITLATLLISYPTAYLLNETKHPQLWLLLIIMPTWINLLLKAYAFIGIFSQAGIANQFLSFIGIGPKQLLFTNFSFIFVAAYIQIPFMVLPIYNSISELNPSYVNASRDLGATNWQTFNRVIFPLTLPGVKAGIQAVFIPSLSLFMLTRLIGGNKVITLGTAIEEHFLTTMNWGMGSTIGVVLIIAMVIIMWLTGSSKKRARKGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW0</accession>
    <name>F9UTW0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine nucleosidase</fullName>
            <ecNumber evidence="4">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_0363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100977.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888394.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0363"/>
    <dbReference type="EnsemblBacteria" id="CCC77880">
        <property type="protein sequence ID" value="CCC77880"/>
        <property type="gene ID" value="lp_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0363"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.307"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_2_2_9"/>
    <dbReference type="OMA" id="AFNKWFL"/>
    <dbReference type="PhylomeDB" id="F9UTW0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-302-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="306" mass="33055" checksum="C9B6DDE2DEF8CA67" modified="2011-10-19" version="1">MSTKIIMDTDPGIDDAAAITFALNHPDLDLQLITTVAGNVTVDKTTLNALKLTRFFNSDVPVAGGAAQPLIKPFEDAVRIHGVSGMPGYDFPTDLAEPLPETAVEALRDYIMAAEQPITLVPTGAYTNIALLFKTYPEVMPHIKEIVAMGGALGKGNMTSAAEFNVFTDPHAAEIMYQSGVPITMVGLDVTMKALLTRKSIEQLPTLGKTGEMLHALFGHYNDRNQTGVAMHDVNTLFYLLHPEAFTTEKMWIDVQTEGPANGETVGDIRGAYHDGKTNATVCVDIDAAAFNKWFLETVAAIDQSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTW9</accession>
    <name>GLPF3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol uptake facilitator protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glpF3</name>
        <name evidence="6" type="ordered locus">lp_0372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to urea and D/L-lactic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641945.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888403.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UTW9"/>
    <dbReference type="SMR" id="F9UTW9"/>
    <dbReference type="STRING" id="220668.lp_0372"/>
    <dbReference type="EnsemblBacteria" id="CCC77889">
        <property type="protein sequence ID" value="CCC77889"/>
        <property type="gene ID" value="lp_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="57027179"/>
    <dbReference type="GeneID" id="66448463"/>
    <dbReference type="KEGG" id="lpl:lp_0372"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.316"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_9"/>
    <dbReference type="OMA" id="MTRTGMF"/>
    <dbReference type="PhylomeDB" id="F9UTW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-311-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441644" description="Glycerol uptake facilitator protein 3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="5">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="240" mass="25054" checksum="13C4D503D6A842CB" modified="2011-10-19" version="1">MMKDPLALQLLGEFLGTFILILLGDGVVAGVTLNKSKAQNAGWVAITLGWGFAVTMGVYASSFMSPAHLNPAVSLGMAVAGKFPWAYVIPYSAAQIAGGVIGGLVVWLHYYPHWQATKDAGAILGIFATGPGIRRYFWNFISEVIGTFVLVFGLLAFTKGQFTAGLNPIVVGILIIAIGLSLGGTTGYAINPARDLGPRIAHAVLPIANKGTSDWAYSWVPIAGPLVGGALGALLFNVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU27</accession>
    <name>F9UU27_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642004.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888461.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0442"/>
    <dbReference type="DNASU" id="1064155"/>
    <dbReference type="EnsemblBacteria" id="CCC77947">
        <property type="protein sequence ID" value="CCC77947"/>
        <property type="gene ID" value="lp_0442"/>
    </dbReference>
    <dbReference type="GeneID" id="57024242"/>
    <dbReference type="KEGG" id="lpl:lp_0442"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.362"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_4_0_9"/>
    <dbReference type="OMA" id="YMRVRDI"/>
    <dbReference type="PhylomeDB" id="F9UU27"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-368-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="101"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="248" mass="28090" checksum="95C5026BC7AD5272" modified="2011-10-19" version="1">MAFFGYKDIDKLSGVDLAIYRFIVEHDEQIPYMRVRELARGAHVSNSSVMRFIRKIGYDSFPEFKVSLRSETPIQKPDAPGIQFVQPSAFPADITKIIRLAAQLMVNADNIVFVGIGASAALGEYASRQTSSLGFNSYVVKDPFYPLLPQLRNTSNNVLVAVSVSGQTSELVEMLNDFVNNPEVNIISITSNLESTIARMSRYALTYRATEERIHQYYDLTSQVPCLYIIEALLRELRHQEVVQHRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU35</accession>
    <name>F9UU35_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642012.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888469.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0450"/>
    <dbReference type="EnsemblBacteria" id="CCC77955">
        <property type="protein sequence ID" value="CCC77955"/>
        <property type="gene ID" value="lp_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="57024250"/>
    <dbReference type="GeneID" id="66448528"/>
    <dbReference type="KEGG" id="lpl:lp_0450"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.370"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_0_9"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="PhylomeDB" id="F9UU35"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-376-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="280" mass="31855" checksum="D493E98A66C5577A" modified="2011-10-19" version="1">MITIGLTTWTEHPSLLGGTEKLTLTEYSGVLPVVEVDTPFYGIPKVTTVAKWQKAVPDKFQFILKANQVMTLHDTYDEGVSMDALKTAYREYRAMLKPLTQHQQLKAVLFQFPPFFERSNRNFHYLQRMVEWLPGVPIAVEFRNQSWYEESVKDAVFSFLKDLGITHVIVDEPHALNDGVSFEPVVTNSKLALLRLHGRNQQGWSAKGANWRSQRTLYRYSDQELAEFKQTVEQLQQQADEVCVIFNNNSGGDAADNAMALKELLGVSFGDLGPHQLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU65</accession>
    <name>F9UU65_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prophage P3 protein 8, DNA primase/helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_3382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890881.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3382"/>
    <dbReference type="DNASU" id="1063844"/>
    <dbReference type="EnsemblBacteria" id="CCC80367">
        <property type="protein sequence ID" value="CCC80367"/>
        <property type="gene ID" value="lp_3382"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3382"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2818"/>
    <dbReference type="eggNOG" id="COG3378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018483_3_0_9"/>
    <dbReference type="OMA" id="KECQEMK"/>
    <dbReference type="PhylomeDB" id="F9UU65"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2855-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="201"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="500" mass="57701" checksum="323555A8D6090180" modified="2011-10-19" version="1">MDDEIKKAITNYDDRPAMTKSTQKVFKNQQEMRTVLRDEVEVWQLIHQTDKQAEANIKPKLPPLAGARIMFRHFDFCLFSHDESERMAAYLPNDGIYTQNYRYLKRLIALMYPSYNLRQALDVIYHLEMMAPVRALTIDRYLVPVNNGIWNLHQHQLIPFSPKYVFTTKIATNYRDNATTPNIKGWTIDNWFDELACGDDEIVELLWEVINDCLNGNYTRKKAIFLFSELGNSGKGTFQELITNLVGMDNVGTLKVNEFDVRFRLAGLVGKTVCIGDDIAPDIYIKDSSNFNSVVTGDLVNIEFKGQDGYTSALRCTIVQSCNGLPNFHNKGGTMRRLVIVPFNNHFQGKGDNWSIRNDYITRKDVLEYVLYKALQLDFDKFSVPEVSKKALADFELDNNPLIGFKVSFFDKLKVDKVPTYYLYEYYKKYCSINGLKALGQSKFIRRFMTCVPLYEKKQAKLSATDINTLDVFKQQDEIIAWPREPLAGKKYNCIVQSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU78</accession>
    <name>F9UU78_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside 2-deoxyribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890894.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3397"/>
    <dbReference type="EnsemblBacteria" id="CCC80380">
        <property type="protein sequence ID" value="CCC80380"/>
        <property type="gene ID" value="lp_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3397"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2830"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117644_0_0_9"/>
    <dbReference type="OMA" id="EWQKATF"/>
    <dbReference type="PhylomeDB" id="F9UU78"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2867-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050144">
        <property type="term" value="F:nucleoside deoxyribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="157" mass="17604" checksum="15E1FB38FE1F6746" modified="2011-10-19" version="1">MNNVYLAAPFFDEAQKERIQQVKSALLANPTINPDGIFIPEEHQFEEEPFGSRAWQQYVYASDMRQVHRADVVVAILDFDMTSATNEPDSGTMFEIGAAVAEKTPVIIVQFDANKELNLMIAQGLTAYFDASKDGLKELSAYNCDDLRSKPAHRPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU85</accession>
    <name>F9UU85_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC80387">
        <property type="protein sequence ID" value="CCC80387"/>
        <property type="gene ID" value="lp_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3406"/>
    <dbReference type="HOGENOM" id="CLU_2246591_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="104" mass="11610" checksum="46E67974D30E0FCC" modified="2011-10-19" version="1">MNTRSNHLIEWLLTLLLIISILINVGWFIFRYGGHYYYMKISSSTGTSPITLPVNVPATGYQYQGLATNSKGEKSIFILIQLLLIQPHSNADKLSESHSIKGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUB8</accession>
    <name>F9UUB8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCC80420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890934.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3442"/>
    <dbReference type="EnsemblBacteria" id="CCC80420">
        <property type="protein sequence ID" value="CCC80420"/>
        <property type="gene ID" value="lp_3442"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3442"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2868"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_134973_10_0_9"/>
    <dbReference type="OMA" id="TCPSCMQ"/>
    <dbReference type="PhylomeDB" id="F9UUB8"/>
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    <dbReference type="Proteomes" id="UP000000432">
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        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388168" evidence="2">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="74" mass="8053" checksum="CAA2AE9CC722F95E" modified="2011-10-19" version="1">MIMKIIMQLGTLTCPSCMTKIEKAVANHDGVENVKVLFNASKVKANFDPEVTNADDLAQVVTGLGYEVENVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH9</accession>
    <name>F9UUH9_LACPL</name>
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        <submittedName>
            <fullName evidence="2">Transcription antiterminator, BlgB family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">bglG4</name>
        <name evidence="2" type="ordered locus">lp_3514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643570.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890995.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3514"/>
    <dbReference type="EnsemblBacteria" id="CCC80481">
        <property type="protein sequence ID" value="CCC80481"/>
        <property type="gene ID" value="lp_3514"/>
    </dbReference>
    <dbReference type="GeneID" id="57026726"/>
    <dbReference type="KEGG" id="lpl:lp_3514"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2929"/>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078802_0_0_9"/>
    <dbReference type="OMA" id="PIRYMEL"/>
    <dbReference type="PhylomeDB" id="F9UUH9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2969-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="64"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="170"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="281" mass="32835" checksum="0ABC9A4B1A972C73" modified="2011-10-19" version="1">MRIKKVFNNNVLLAEKNGREVVLIGKGIGFKKHTGDDVEQQQITKIYTPEGDNWISNFQSLMADIEPEYFEVASQIIELAEQQLQTTFNVYLLISLTDHIHFAVYRHHHQMDIHNEILWETKRIYHREFQVGMQALALIKKHFDVTLLEDEAGFIAMKFVENSMADSNTDQTLAMTKLINDILNIVKYQLSLTMPDESVSLQRFLVHLRFFAERLTLKRPDQSQGADDDFLFEHLSKQYPRAFACVQKIAVFVKKSTEQTVSVNERIYLIMHIQRMLNENQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P80214</accession>
    <accession>F9UU02</accession>
    <name>PLNA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>Bacteriocin plantaricin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">plnA</name>
        <name type="ordered locus">lp_0415</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Appl. Environ. Microbiol." volume="60" first="160" last="166">
            <title>The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system.</title>
            <authorList>
                <person name="Diep B.D."/>
                <person name="Havarstein L.S."/>
                <person name="Nissen-Meyer J."/>
                <person name="Nes F.I."/>
            </authorList>
            <dbReference type="PubMed" id="8117074"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>C11</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4472" last="4483">
            <title>Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.</title>
            <authorList>
                <person name="Diep D.B."/>
                <person name="Havarstein L.S."/>
                <person name="Nes I.F."/>
            </authorList>
            <dbReference type="PubMed" id="8755874"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>C11</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1993" name="J. Gen. Microbiol." volume="139" first="1973" last="1978">
            <title>Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.</title>
            <authorList>
                <person name="Nissen-Meyer J."/>
                <person name="Granly Larsen A.G."/>
                <person name="Sletten K."/>
                <person name="Daeschel M."/>
                <person name="Nes I.F."/>
            </authorList>
            <dbReference type="PubMed" id="8245827"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 26-47</scope>
        <source>
            <strain>C11</strain>
        </source>
    </reference>
    <comment type="function">
        <text>This heat stable bacteriocin inhibits the growth of closely related Lactobacillus species. It may act as a pore-forming protein, creating a channel in the cell membrane through a 'barrel stave' mechanism.</text>
    </comment>
    <comment type="subunit">
        <text>Active plantaricin A is composed of an alpha chain and a beta chain.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The beta chain sequence is shown.</text>
    </comment>
    <dbReference type="EMBL" id="X75323">
        <property type="protein sequence ID" value="CAA53069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X94434">
        <property type="protein sequence ID" value="CAA64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A45913">
        <property type="entry name" value="A45913"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641979.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888436.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="1YTR">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=23-48"/>
    </dbReference>
    <dbReference type="PDBsum" id="1YTR"/>
    <dbReference type="AlphaFoldDB" id="P80214"/>
    <dbReference type="BMRB" id="P80214"/>
    <dbReference type="SMR" id="P80214"/>
    <dbReference type="STRING" id="220668.lp_0415"/>
    <dbReference type="TCDB" id="1.C.22.1.6">
        <property type="family name" value="the lactococcin a (lactococcin a) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77922">
        <property type="protein sequence ID" value="CCC77922"/>
        <property type="gene ID" value="lp_0415"/>
    </dbReference>
    <dbReference type="GeneID" id="57024218"/>
    <dbReference type="KEGG" id="lpl:lp_0415"/>
    <dbReference type="eggNOG" id="ENOG5032N8N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3154236_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-344-MON"/>
    <dbReference type="EvolutionaryTrace" id="P80214"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010133">
        <property type="entry name" value="Bacteriocin_signal_seq"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01847">
        <property type="entry name" value="bacteriocin_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0044">Antibiotic</keyword>
    <keyword id="KW-0929">Antimicrobial</keyword>
    <keyword id="KW-0078">Bacteriocin</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="propeptide" id="PRO_0000002776" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_0000002777" description="Bacteriocin plantaricin-A">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In the alpha chain.">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="8245827"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="1YTR"/>
        </source>
    </evidence>
    <sequence length="48" mass="5458" checksum="6C584810DE50D3F5" modified="1995-11-01" version="2" precursor="true">MKIQIKGMKQLSNKEMQKIVGGKSSAYSLQMGATAIKQVKKLFKKWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q6LWF1</accession>
    <name>Q6LWF1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">traK</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>pWCFS103</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2005" name="Appl. Environ. Microbiol." volume="71" first="1223" last="1230">
            <title>Functional analysis of three plasmids from Lactobacillus plantarum.</title>
            <authorList>
                <person name="van Kranenburg R."/>
                <person name="Golic N."/>
                <person name="Bongers R."/>
                <person name="Leer R.J."/>
                <person name="de Vos W.M."/>
                <person name="Siezen R.J."/>
                <person name="Kleerebezem M."/>
            </authorList>
            <dbReference type="PubMed" id="15746322"/>
            <dbReference type="DOI" id="10.1128/AEM.71.3.1223-1230.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR377166">
        <property type="protein sequence ID" value="CAG17857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011222033.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_133740.1">
        <property type="nucleotide sequence ID" value="NC_006377.1"/>
    </dbReference>
    <dbReference type="STRING" id="220668.45723576"/>
    <dbReference type="EnsemblBacteria" id="CAG17857">
        <property type="protein sequence ID" value="CAG17857"/>
        <property type="gene ID" value="CAG17857"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:CAG17857"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3104"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015347_5_0_9"/>
    <dbReference type="OMA" id="HAVKICL"/>
    <dbReference type="PhylomeDB" id="Q6LWF1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3157-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Plasmid pWCFS103"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG17857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="503" mass="56760" checksum="34F54C9B2156BBDB" modified="2004-07-05" version="1">MNGTILGIVDKRIVYQNNSTKPNRNIFVVGGPGSYKTQSVVITNLFNETENSIVVTDPKGELYEKTAGIKLAQGYQVHVVNFANMAHSDRYNPFDYIQRDIQAETVATKIVQSENSEGKKDVWFSTQRQLLKALILFVMNHRSPEQRNLAGVTQVLQENDVEAEEKGADSPLDTLFLDLTMTDPARRAYELGFKKAKGEMKASIIESLLATISKFVDKEVANFTSFSDFDLKEIGKAKVVMYVIIPVMDNTYESFINLFFSQLFDELYKLAADHHAKLPHQVDFILDEFVNLGKFPKYEEFLATCRGYGIGVTTICQTLTQLQALYGKDKAESILGNHAVKICLNAANDVTAKYFSDLLGKSTVKVETGSESTSHSKEESHSKSDSYSYTSRSLMTPDEIMRMPEDQSLLIFSNARPVKATKAFQFKLFPGADHLVNLSQNEYQGQPEASQETHFKNKVDKWNQTVKAQHQAKKDDQTTDDEEDKLQDNIDQELESRHKKMLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VM6</accession>
    <accession>F9UPX8</accession>
    <name>DLTA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-alanine--D-alanyl carrier protein ligase</fullName>
            <shortName evidence="1">DCL</shortName>
            <ecNumber evidence="1">6.2.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-alanine--poly(phosphoribitol) ligase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">D-alanine-activating enzyme</fullName>
            <shortName evidence="1">DAE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dltA</name>
        <name type="ordered locus">lp_2019</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:55132"/>
            <dbReference type="Rhea" id="RHEA-COMP:14102"/>
            <dbReference type="Rhea" id="RHEA-COMP:14103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138620"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; lipoteichoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.54" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640707.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889781.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VM6"/>
    <dbReference type="SMR" id="Q88VM6"/>
    <dbReference type="STRING" id="220668.lp_2019"/>
    <dbReference type="EnsemblBacteria" id="CCC79267">
        <property type="protein sequence ID" value="CCC79267"/>
        <property type="gene ID" value="lp_2019"/>
    </dbReference>
    <dbReference type="GeneID" id="57025575"/>
    <dbReference type="KEGG" id="lpl:lp_2019"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1706"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_9"/>
    <dbReference type="OMA" id="PNIRFIR"/>
    <dbReference type="PhylomeDB" id="Q88VM6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1729-MON"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047473">
        <property type="term" value="F:D-alanine [D-alanyl carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070395">
        <property type="term" value="P:lipoteichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05945">
        <property type="entry name" value="DltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00593">
        <property type="entry name" value="DltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010072">
        <property type="entry name" value="DltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044507">
        <property type="entry name" value="DltA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01734">
        <property type="entry name" value="D-ala-DACP-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213144" description="D-alanine--D-alanyl carrier protein ligase">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="293"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>D-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="396"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>D-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00593"/>
        </source>
    </evidence>
    <sequence length="508" mass="56081" checksum="F3F6B747A3C59361" modified="2003-06-06" version="1">MIKNIITTIDDYARTQPNNVVYDVQGVTHTYAELKAYSDALAAHLDTLDLPAKDPIIVFGGQTFEMIATFLGVVKSGRAYIPIDTHSPNERLTMINEIAKPAAVIAVADLPTGVGTTPVITPDQLAAIFATPVDYQADHVVSGDDNYYIIFTSGTTGMPKGVQISHDNLVSYVDWMLSDDFGLPDQPNSLSQPPYSFDLSVMDVYPTLALGGTLYALPKAVTDDFKQLFAALPTLPINVWVSTPSFMDICLLEPKFNAENLPTLTHFLFCGEELTHKTAATLKKRFPDARIFNTYGPTETCVAVTQIEITDAALAQYDRLPIGYAKADTRILVVDENGEAVPNGTEGELIIAGPSVSKGYLNNSEKTAKAFFELDGQPAYHSGDIGTMDADGLFRYRGRVDFQIKMHGYRIELEEVDHFLAQQQHIKQAVAVPKYDKEHKVTQMIAYVVPKPNDFESDFALTTAIKKDLQGMMMEYMIPQRFVYQTSLPLTPNGKIDVKSIIKEVNPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-28" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VP9</accession>
    <accession>F9UPV3</accession>
    <name>PRMA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="1">L11 Mtase</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA</name>
        <name type="ordered locus">lp_1990</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101614.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889756.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VP9"/>
    <dbReference type="SMR" id="Q88VP9"/>
    <dbReference type="STRING" id="220668.lp_1990"/>
    <dbReference type="EnsemblBacteria" id="CCC79242">
        <property type="protein sequence ID" value="CCC79242"/>
        <property type="gene ID" value="lp_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1990"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1682"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_9"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="PhylomeDB" id="Q88VP9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1706-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000192271" description="Ribosomal protein L11 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <sequence length="316" mass="34101" checksum="9540D3C86EEBC35B" modified="2003-06-01" version="1">MKWTEVTVSTSNEAVEAVANILMEAGASGVKIDDALDYQNLKPDRYGEIIDLATIPHVTSGAKISAYYPETVFVPEVIPTIKQRVSQLTDFGLNPAPNEVSMTALSDEDWATAWKKYYHPVRVTRYLTIVPSWEQYQPVQSGELVLRLDPGQAFGTGTHPTTKLCLQALETVINGGEHLIDVGTGSGVLSIAAKAMGVGAVEAYDLDDVAVASAQTNLDLNPVAKDVHVAANDLLAGIDTQADIIVANILAEIIIPLVPQARQNLKRGGYFIASGIIDDKFQVVMTTIKEAGFQITQHTQMGDWHGIVAYLPTAED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88W05</accession>
    <accession>F9UPK0</accession>
    <name>TYSY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate synthase</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyA</name>
        <name type="ordered locus">lp_1870</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640579.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889653.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88W05"/>
    <dbReference type="SMR" id="Q88W05"/>
    <dbReference type="STRING" id="220668.lp_1870"/>
    <dbReference type="EnsemblBacteria" id="CCC79139">
        <property type="protein sequence ID" value="CCC79139"/>
        <property type="gene ID" value="lp_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1870"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1576"/>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_9"/>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="PhylomeDB" id="Q88W05"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1601-MON"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000140970" description="Thymidylate synthase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <sequence length="316" mass="36014" checksum="93B673AC977F6EC1" modified="2003-06-01" version="1">MLEDSYLQLARTILEHGTYKDDRTGTGTYSVFGYQMRFDLSQGFPLLTTKKVPFGLIKSELLWFLHGDTNIQYLLQHHNHIWDEWAFKNWVTSADYDGPDMTNFEHRRLDDPDFAPIYQAQMQTFDDQILTDDAFAAKYGNLGDVYGAQWRHWQTRQGKTIDQIANVIEMIKTHPDSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDVFLGVPFNIASYALLTHLIAKETGLAVGEFVHTLGDAHIYTNHVEQVKTQLTRQPRPAPQLTLSGAHDSIFDYQMSDIKLSGYDPAPAIKAPVAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WD3</accession>
    <accession>F9UP70</accession>
    <name>Y1708_LACPL</name>
    <protein>
        <recommendedName>
            <fullName>UPF0337 protein lp_1708</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_1708</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640447.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889523.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WD3"/>
    <dbReference type="SMR" id="Q88WD3"/>
    <dbReference type="EnsemblBacteria" id="CCC79009">
        <property type="protein sequence ID" value="CCC79009"/>
        <property type="gene ID" value="lp_1708"/>
    </dbReference>
    <dbReference type="GeneID" id="57025338"/>
    <dbReference type="GeneID" id="66449573"/>
    <dbReference type="KEGG" id="lpl:lp_1708"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1443"/>
    <dbReference type="eggNOG" id="COG3237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135567_0_2_9"/>
    <dbReference type="OMA" id="MGDESAM"/>
    <dbReference type="PhylomeDB" id="Q88WD3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1472-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000210007" description="UPF0337 protein lp_1708">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="73" mass="7987" checksum="BC0A0B855461830C" modified="2003-06-01" version="1">MSDVNKKFDSKKDQLSGKAKEVEGKVTGDRAREAQGKTQSLMGKAKDKLADAEETVKGVVDEAKDKMKKKSDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XU0</accession>
    <accession>F9UMQ2</accession>
    <name>AROB_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
            <shortName evidence="1">DHQS</shortName>
            <ecNumber evidence="1">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroB</name>
        <name type="ordered locus">lp_1086</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101252.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889005.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XU0"/>
    <dbReference type="SMR" id="Q88XU0"/>
    <dbReference type="STRING" id="220668.lp_1086"/>
    <dbReference type="EnsemblBacteria" id="CCC78491">
        <property type="protein sequence ID" value="CCC78491"/>
        <property type="gene ID" value="lp_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1086"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.920"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_9"/>
    <dbReference type="PhylomeDB" id="Q88XU0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-934-MON"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000140748" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <sequence length="359" mass="38105" checksum="622BC9C7023B6E0C" modified="2011-11-16" version="2">MTNIEVKTRVKQYQIKIMINSLHHLGTLVTKVWCARQVAVVTDTNVGPYYAKLVTDELTAAGFKVRVMTVPAGEESKSWSQVQSLIDQLSAAHFSRSDGVLALGGGVVGDLAGFVASIYMRGIALIQVPTSLLAQVDSSVGGKTAIDLPTGKNLVGSFYQPDLVVIDPAILVTLPPRMLAEGYGEIVKCAALVGGDFWQSLHQITSVAAILPAAPDLIAASVAFKARVVMADEHEQGQRQLLNFGHTIGHAVELLADGQLMHGEAVAIGLVQVCRLFAAHGLAPTSLTSTLKARLMAVGLPTELPPIAPQAVAAVMQHDKKVHGTALTWVYLSAVGQPHLYPIAVTDLATWMGDLWSVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XY0</accession>
    <accession>F9UML1</accession>
    <name>RS3_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">lp_1040</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638066.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888964.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XY0"/>
    <dbReference type="SMR" id="Q88XY0"/>
    <dbReference type="STRING" id="220668.lp_1040"/>
    <dbReference type="EnsemblBacteria" id="CCC78450">
        <property type="protein sequence ID" value="CCC78450"/>
        <property type="gene ID" value="lp_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="49393323"/>
    <dbReference type="GeneID" id="57024697"/>
    <dbReference type="GeneID" id="66448953"/>
    <dbReference type="KEGG" id="lpl:lp_1040"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.877"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_9"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="PhylomeDB" id="Q88XY0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-893-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130135" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <sequence length="217" mass="24208" checksum="3DA7A3E5259C13BB" modified="2003-06-01" version="1">MGQKVNPTGLRVGIIRDWEAKWYAEKDFAAYLNEDLRIRKYIEQRLADASVSTVEIERAANRVNISIHTAKPGMVIGKGGSEVEALRKELNNLTGKRVHINIIEIKKPDLDAKLVGESIARQLEGRVAFRRAMRGAMQRTMRSGAKGIKTQVAGRLNGADMSRVEAYSDGTVPLHTLRADIDYSWVEARTTYGKLGVKTWIYRGEILPEKKSAKGGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q88ZT7</accession>
    <accession>F9UT19</accession>
    <name>CRCB2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB2</name>
        <name type="ordered locus">lp_0214</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641806.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888264.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88ZT7"/>
    <dbReference type="SMR" id="Q88ZT7"/>
    <dbReference type="STRING" id="220668.lp_0214"/>
    <dbReference type="EnsemblBacteria" id="CCC77750">
        <property type="protein sequence ID" value="CCC77750"/>
        <property type="gene ID" value="lp_0214"/>
    </dbReference>
    <dbReference type="GeneID" id="57027038"/>
    <dbReference type="KEGG" id="lpl:lp_0214"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.177"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_1_2_9"/>
    <dbReference type="OMA" id="CGGFTTM"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-172-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000110117" description="Putative fluoride ion transporter CrcB 2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="127" mass="13647" checksum="D9342158A809904C" modified="2003-06-01" version="1">MKKIIAITGFAMLGGGLREGLSLLVTWPQHFWITCLINIVGAFVLSLITNLLPARLPVSEDIVIGMSVGFVGSFTTFSTFTFETLQSFQSGHSVLALSYVAASLGLGLLAGLAGNFLSTYWLPKEEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q890D1</accession>
    <accession>F9USS5</accession>
    <name>LARO_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nickel import ATP-binding protein LarO</fullName>
            <ecNumber evidence="5">7.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Energy-coupling factor transporter ATP-binding protein LarO</fullName>
            <shortName evidence="5">ECF transporter A component LarO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nickel transport ATP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">larO</name>
        <name type="ordered locus">lp_0100</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3615" last="3615">
            <title>Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.</title>
            <authorList>
                <person name="Desguin B."/>
                <person name="Goffin P."/>
                <person name="Viaene E."/>
                <person name="Kleerebezem M."/>
                <person name="Martin-Diaconescu V."/>
                <person name="Maroney M.J."/>
                <person name="Declercq J.P."/>
                <person name="Soumillion P."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="24710389"/>
            <dbReference type="DOI" id="10.1038/NCOMMS4615"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable ATP-binding component of the energy-coupling factor (ECF) transporter complex LarMNQO involved in nickel import. LarO is presumably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, LarO), a transmembrane protein (T component, LarQ) and a fused possible substrate-capture protein (S component, LarMN) of unknown stoichiometry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Induced by L-lactate but not by a racemic mixture of DL-lactate. Makes part of the larR(MN)QO operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Deletion of both larO and larQ leads to a loss of lactate racemase activity. Addition of Ni(2+) (but not Co(2+)) restores lactate racemase activity in this mutant.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888170.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890D1"/>
    <dbReference type="SMR" id="Q890D1"/>
    <dbReference type="STRING" id="220668.lp_0100"/>
    <dbReference type="EnsemblBacteria" id="CCC77656">
        <property type="protein sequence ID" value="CCC77656"/>
        <property type="gene ID" value="lp_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0100"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.80"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="PhylomeDB" id="Q890D1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-78-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015675">
        <property type="term" value="P:nickel cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0921">Nickel transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092023" description="Nickel import ATP-binding protein LarO">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A2RI02"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="24710389"/>
        </source>
    </evidence>
    <sequence length="241" mass="26336" checksum="84E826265AC7A5BC" modified="2011-11-16" version="2">MIKLVNICYDYPDTCGLKDLSLTVNSGDFICLMGPNGSGKSTLLRLLSGLASPTSGAYQFHDQPITTTYLADAQNRQQLHQRIGMVFQNTDVQLFNTSVTEEVAFGPRQLGLSAAMVAQRVADCLQLTDCANLADRVPYQLSGGEKKRVALASVLALNPEILLLDEPLNGLTIAAQQQMLTLLQRLQAAGKTIIMASHNYQQVQAVGERFIIFNSTHQVDADLTRADLDQQPARQAQLMTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q890I8</accession>
    <accession>F9US52</accession>
    <name>GLGA_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA</name>
        <name type="ordered locus">lp_0023</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100853.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888113.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890I8"/>
    <dbReference type="SMR" id="Q890I8"/>
    <dbReference type="STRING" id="220668.lp_0023"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC77599">
        <property type="protein sequence ID" value="CCC77599"/>
        <property type="gene ID" value="lp_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0023"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.21"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_9"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="PhylomeDB" id="Q890I8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-20-MON"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000188622" description="Glycogen synthase">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="479" mass="54400" checksum="FC3B39BCE97EC8E6" modified="2003-06-01" version="1">MTRVLFAAAEAAPFYKTGGLGDVSMALPRALQAEGIETRVVIPYYPHQMPTEYQQQLVPVTHFTVQVGEHAMYCGIKTLTVAHVQYYLIDNLDYFGREGLYGYWDDGARFAFFQMAVCEMMEQIDYIPDILQLNDWHTAFIPVLLAEKYYWIEAYRDIKTVLTIHNLQFQGVYDPIILDSLFRIGTETYTEAGVAFYDQVNWLKGGINFADAVNTVSPTYAQEIQTPAFGERLDGVLRANRYKLSGILNGIDMQLYDPATDLALTANYSAKDLKPKRQNKRALQRRLGLPVKNMPVLAVVSRLTKQKGIDLLLDALNPFLQQQDVQLIVLGTGDPALERALRTYQSAYPQKVVAAIQFDTQLAQQIYAASDIFLMPSAFEPCGLSQMMAMHYGTLPIVHAVGGLRDTVIPYNRYTGQGTGFSFDDYQPAVLRKIMILAVTLYRQHPLVWRQLQHQAMTCDFGWEHSAQQYRATYQKLMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q890J0</accession>
    <accession>F9US50</accession>
    <name>GLGC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgC</name>
        <name type="ordered locus">lp_0021</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641645.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888111.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890J0"/>
    <dbReference type="SMR" id="Q890J0"/>
    <dbReference type="STRING" id="220668.lp_0021"/>
    <dbReference type="EnsemblBacteria" id="CCC77597">
        <property type="protein sequence ID" value="CCC77597"/>
        <property type="gene ID" value="lp_0021"/>
    </dbReference>
    <dbReference type="GeneID" id="57026882"/>
    <dbReference type="KEGG" id="lpl:lp_0021"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.19"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_9"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="PhylomeDB" id="Q890J0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-18-MON"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000195302" description="Glucose-1-phosphate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <sequence length="379" mass="42044" checksum="FD70CA73F8458731" modified="2003-06-01" version="1">MQDEMLGIILAGGQGTRLGKLTKDTAKPAVPFGGRYRIIDFTLSNCANSGVNTVGVITQYQPLELNAHIGSGASWGFDSLNGGVTVLQPYSSSEGEKFFQGTAHAIYQNIEYIDQQDPKYLLVLSGDHIYKMDYDAMLKYHQEKKASLTVGVIHVTNEEAKRFGMMNTDATDRIIEFEEKPEHPKSDKASMGIYIFNWPTLRDYLVKSYATDKSLEDFGKNVIPSYLANNESVYAYAFKGYWRDVGTIKSLWQANMEFLSPHNRLNIGDRYWRIYSKAEVLPPMFLTETSQVNNAMVVDSCYVAGEIDHSILSQRVSVGMGSRVVDSMIMPGATIGKNVVIDHALIGEDAVIGDDAQIIGTTDKIAVVGYHETMGVEQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RE01</accession>
    <accession>F9UQS1</accession>
    <name>UPP_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">lp_2374</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>L. plantarum uracil phosphoribosyltransferase (upp) and uracil permease (pyrP) genes.</title>
            <authorList>
                <person name="Horvath P."/>
                <person name="Hubert J.C."/>
                <person name="Kammerer B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AJ012720">
        <property type="protein sequence ID" value="CAB65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003639227.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890074.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RE01"/>
    <dbReference type="SMR" id="Q9RE01"/>
    <dbReference type="STRING" id="220668.lp_2374"/>
    <dbReference type="EnsemblBacteria" id="CCC79560">
        <property type="protein sequence ID" value="CCC79560"/>
        <property type="gene ID" value="lp_2374"/>
    </dbReference>
    <dbReference type="GeneID" id="49394542"/>
    <dbReference type="GeneID" id="57025904"/>
    <dbReference type="KEGG" id="lpl:lp_2374"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2006"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_9"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="PhylomeDB" id="Q9RE01"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2045-MON"/>
    <dbReference type="BRENDA" id="2.4.2.9">
        <property type="organism ID" value="2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120838" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <sequence length="209" mass="22972" checksum="6F1FF50794905F69" modified="2000-05-01" version="1">MGKFEVLDHPLIQHKLTIIREKNCGTKVFREMVNEISTLMAYEVSRDMPLKDIEIETPIAKSTQKTLAGKKVAIVPILRAGLGMVDGFLNMIPAAKVGHVGMYRDEKTLKPVEYFVKLPSDISQRQLFVVDPMLATGGSAIMAMDMLKKRGASNIKFMCLVAAPEGVKALRDAHPDIDVYTAALDDHLNEDGYIVPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UKX8</accession>
    <name>F9UKX8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">deoP</name>
        <name evidence="9" type="ordered locus">lp_0498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    <dbReference type="eggNOG" id="COG0738">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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            <begin position="29"/>
            <end position="50"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCC77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="57024349"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="144" mass="16158" checksum="B1742116FCBEC806" modified="2011-10-19" version="1">MKKATIQTYMPVLSKVIESTEKMGEELNPSFEKLRQAIDNDAVAKMVPAEFNDIQMEFSDGTEQYQQNLAQLKKVAVPARLMGRHRNLLAAYEAYTNACAAMTASMNIDDQTIDVAAFNQAETDQETEMGRVSNNVQRIMNTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UL67</accession>
    <name>F9UL67_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extracellular zinc metalloproteinase, M10 family</fullName>
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    <gene>
        <name evidence="6" type="primary">zmp2</name>
        <name evidence="6" type="ordered locus">lp_0600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0600"/>
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        <property type="protein sequence ID" value="CCC78082"/>
        <property type="gene ID" value="lp_0600"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ZnMc" evidence="5">
        <location>
            <begin position="77"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="230" mass="26470" checksum="DACE485AC9D0F875" modified="2011-10-19" version="1">MMKHKNLLLLIIMSLGFCGMLLMFAPQISTLINPNASRVEADKASGHDTMHDQVYYNDQMDNYQYDYINNGTKVLNYKARFKSRVITYRITSDSKVYRAIWLRAVERWNNTNAVRLVEAKDQAKAQITLGESEDETETTGSEIGRTWRTYYQSGSQGTTWMDSAKCVIYTNRFPASNHSVEYKLSVATHELGHALGLEHENNKSAVMYYQSHRAAHITTREISTLKQMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULK8</accession>
    <name>F9ULK8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator, LacI family, ribose</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsR</name>
        <name evidence="5" type="ordered locus">lp_3661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643604.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891129.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3661"/>
    <dbReference type="DNASU" id="1061589"/>
    <dbReference type="EnsemblBacteria" id="CCC80615">
        <property type="protein sequence ID" value="CCC80615"/>
        <property type="gene ID" value="lp_3661"/>
    </dbReference>
    <dbReference type="GeneID" id="57026841"/>
    <dbReference type="KEGG" id="lpl:lp_3661"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.3059"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_9"/>
    <dbReference type="OMA" id="CTGIVCG"/>
    <dbReference type="PhylomeDB" id="F9ULK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-3102-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="332" mass="36855" checksum="1B0F7A75B3D827C7" modified="2011-10-19" version="1">MKNKAVTIKDVARLAERSIATVSQILNGHGDKFSAATVAKVEAARDELNYEPDYFAQRMIKKTSKTIGVLVPDIRNPFFGELLRGIENVLYQQNFITMLCNADLDEDKERVYLDELSRRGVDGFIIASSAVSNNAINDILRQKGHPFIVLDQKRAEGFSDSVLTDDYDGGRQAAQHLKDLGHRQVAVLIPAKPSANVQKRLSGFYSVYPRTAVHVIATPLSKVGGRQVVPEILATGVTGIFAVNDEIAFGVYLGMAEHDKRIPDDYSVIGYDDVEMCQYVAPQLTTIAQPIFELGQTTANQLLDRIANPQQPWEEHHLPVKLIERNSTAHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULR8</accession>
    <name>F9ULR8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P1 protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101130.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888671.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0680"/>
    <dbReference type="EnsemblBacteria" id="CCC78157">
        <property type="protein sequence ID" value="CCC78157"/>
        <property type="gene ID" value="lp_0680"/>
    </dbReference>
    <dbReference type="GeneID" id="57025312"/>
    <dbReference type="KEGG" id="lpl:lp_0680"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.572"/>
    <dbReference type="eggNOG" id="ENOG5030BI9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2973822_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-591-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010022">
        <property type="entry name" value="XkdX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09693">
        <property type="entry name" value="Phage_XkdX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="58" mass="6664" checksum="EB263C03FEEF5A55" modified="2011-10-19" version="1">MYIIFKFAYQLWHTMTKEEVSLEVIKGGITPVEYQTITGEAYIEMATGDEQDETTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9ULU4</accession>
    <name>F9ULU4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE1</name>
        <name evidence="10" type="ordered locus">lp_0709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643943.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888697.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0709"/>
    <dbReference type="EnsemblBacteria" id="CCC78183">
        <property type="protein sequence ID" value="CCC78183"/>
        <property type="gene ID" value="lp_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0709"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.596"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_9"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="PhylomeDB" id="F9ULU4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-618-MON"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="331" mass="36150" checksum="D4C4B47C6D252296" modified="2011-10-19" version="1">MSILVLGGAGYIGSHMVDRLVEHGTDVVVVDNLVTGHRAAVNSAAKFYQGDLRDADFLNHVFDTEDIEAVVHFAAFSIVPESMSKPLKYFDNNTGGMITLLETMQAHDVKQIVFSSTAATYGTPKQIPIKETDPQLPINPYGASKLMMEQIMHWADVAYGIKFVALRYFNVAGAKPDGSIGEDHGPETHLVPIILQVAQGKRDELKIFGDDYNTPDGTNVRDYVHVVDLADAHILALKYLAAGNDSNAFNLGSSTGFSNKQMLAAAREVTGQPIPAKLAPRRPGDPDSLVAASDKARDVLGWQPNYDNVNDIIETAWAWTQKHPNGYDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM31</accession>
    <name>F9UM31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">exoA</name>
        <name evidence="4" type="ordered locus">lp_0812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643984.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888784.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0812"/>
    <dbReference type="EnsemblBacteria" id="CCC78270">
        <property type="protein sequence ID" value="CCC78270"/>
        <property type="gene ID" value="lp_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0812"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.687"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_3_9"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="PhylomeDB" id="F9UM31"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-706-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC78270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="254" mass="29603" checksum="58183D3C6898B7DC" modified="2011-10-19" version="1">MKLISWNVNGLRAAVKHGFVTTFNELDADFFCVQETKLQAGQIELDFPGYYQYWNYAERKGYSGTAIFTKHEPLNVTYGIGVPEFDDEGRVITLEYADYYVLTCYTPNSGGELKRLDYRQQWEDAFLTYINSLSANKPLIFCGDLNVAHENIDLKNWRSNHHSAGFTDEERTKFDRLLAAGYTDTFRHFYPDQTDIYSWWSYRGHARDNNSGWRIDYFITSQQLDSQLLNARIHNEIFGSDHCPVELDIILPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM75</accession>
    <name>F9UM75_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644009.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888828.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0864"/>
    <dbReference type="EnsemblBacteria" id="CCC78314">
        <property type="protein sequence ID" value="CCC78314"/>
        <property type="gene ID" value="lp_0864"/>
    </dbReference>
    <dbReference type="GeneID" id="57024555"/>
    <dbReference type="KEGG" id="lpl:lp_0864"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.734"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_14_4_9"/>
    <dbReference type="OMA" id="SCKERRA"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-750-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="Ap4A_hydrolase_human_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="139" mass="15646" checksum="C1DD1F7AC894BE91" modified="2011-10-19" version="1">MSTEVASGAVVYQQKDGHPAYLLLQSATSDFWGFPKGHVEGNETLAEAARREIREETQIEATLDTNFKAYTEYDLPNGNLKQVTLFVSEVPSGVVVTRQQAEISAIGWFDYAAARERLTYDNLKQMLDQANTYIEQHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UM81</accession>
    <name>F9UM81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph1</name>
        <name evidence="1" type="ordered locus">lp_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2006-06" db="PDB data bank">
            <title>Crystal structure of putative phosphoglycolate phosphatase (np_784602.1) from Lactobacillus plantarum at 1.50 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS)</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101186.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888834.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="PDB" id="2HDO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-208"/>
    </dbReference>
    <dbReference type="PDBsum" id="2HDO"/>
    <dbReference type="SMR" id="F9UM81"/>
    <dbReference type="STRING" id="220668.lp_0872"/>
    <dbReference type="DNASU" id="1062260"/>
    <dbReference type="EnsemblBacteria" id="CCC78320">
        <property type="protein sequence ID" value="CCC78320"/>
        <property type="gene ID" value="lp_0872"/>
    </dbReference>
    <dbReference type="GeneID" id="57024560"/>
    <dbReference type="KEGG" id="lpl:lp_0872"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.740"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_9"/>
    <dbReference type="OMA" id="WAVPYGY"/>
    <dbReference type="PhylomeDB" id="F9UM81"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-756-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2HDO"/>
        </source>
    </evidence>
    <sequence length="208" mass="23242" checksum="D04F86435512857E" modified="2011-10-19" version="1">MTYQALMFDIDGTLTNSQPAYTTVMREVLATYGKPFSPAQAQKTFPMAAEQAMTELGIAASEFDHFQAQYEDVMASHYDQIELYPGITSLFEQLPSELRLGIVTSQRRNELESGMRSYPFMMRMAVTISADDTPKRKPDPLPLLTALEKVNVAPQNALFIGDSVSDEQTAQAANVDFGLAVWGMDPNADHQKVAHRFQKPLDILELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMG4</accession>
    <name>F9UMG4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888917.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0970"/>
    <dbReference type="EnsemblBacteria" id="CCC78403">
        <property type="protein sequence ID" value="CCC78403"/>
        <property type="gene ID" value="lp_0970"/>
    </dbReference>
    <dbReference type="GeneID" id="57024644"/>
    <dbReference type="GeneID" id="66448898"/>
    <dbReference type="KEGG" id="lpl:lp_0970"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.826"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087235_2_0_9"/>
    <dbReference type="PhylomeDB" id="F9UMG4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-839-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="189" mass="20464" checksum="5CA8697B71B66C2B" modified="2011-10-19" version="1">MMEIRTAQPQDSAQIAPLIAMIYRDMEMPVLKNVSEADLLAMLTELYQRPANLDGLAQTFVAVMDHKIVGVAFGHLAKNEVAVNDLLRTTSGHHAGFEAPLELGGETRPNEWYLSMLAVDPQAQGHGVGSALLEALPGLVGQLGATKLSLNVDDGNPRAAKLYHRHGFVPDGQLMIGTHPYQHLVKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMQ4</accession>
    <name>F9UMQ4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003596658.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889007.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9UMQ4"/>
    <dbReference type="STRING" id="220668.lp_1088"/>
    <dbReference type="EnsemblBacteria" id="CCC78493">
        <property type="protein sequence ID" value="CCC78493"/>
        <property type="gene ID" value="lp_1088"/>
    </dbReference>
    <dbReference type="GeneID" id="57024739"/>
    <dbReference type="KEGG" id="lpl:lp_1088"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.922"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_0_9"/>
    <dbReference type="OMA" id="PEVAMTI"/>
    <dbReference type="PhylomeDB" id="F9UMQ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-936-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="11698" checksum="7EFA4BBA00D11461" modified="2011-10-19" version="1">MISMDTQSTLKTQALAALSTVIDPELGVNIVDLGLIYDVAYDADLKLCTVTMTLTIMGCPLTGYLNDHIKSALMTVAGIDQVLINLVWEPAWSLDKMSRAAKMTLGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMS7</accession>
    <name>F9UMS7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mleP2</name>
        <name evidence="8" type="ordered locus">lp_1119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101262.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889030.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1119"/>
    <dbReference type="DNASU" id="1063291"/>
    <dbReference type="EnsemblBacteria" id="CCC78516">
        <property type="protein sequence ID" value="CCC78516"/>
        <property type="gene ID" value="lp_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1119"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.946"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_2_9"/>
    <dbReference type="OMA" id="NTVSTWA"/>
    <dbReference type="PhylomeDB" id="F9UMS7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-959-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC78516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="323" mass="35268" checksum="EFAA82DC24941281" modified="2011-10-19" version="1">MGVLWNSIQSVLVVVLIMILGFVLRRAGWFDDKFAGTISKFIKNIALPASIFVSVLSRLTRGQLGSFAGYLAYAFLAVIIGYLIAFALVKVMRVRPGRKGIFINAIVNANTIFIGLPLNIALFGDKSMTYFLVYYIVNTVSTWAFGVFLISNDDPTKSKEKTHNKIDWKKVIPMPLVGFLVALIFLLLNIPIMKVSFVSSTLTYVGNLVTPLSLIYIGIVLADAGLKSIRFDRDTVVALVGRFILSPIVMILVLMVAGNLGASFPTLASQTLIVQSATPMLAVLPILANEAHGDVEYATNIVTTSTVLFIVVVPVLMTLIQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UMZ0</accession>
    <name>F9UMZ0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889093.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1192"/>
    <dbReference type="EnsemblBacteria" id="CCC78579">
        <property type="protein sequence ID" value="CCC78579"/>
        <property type="gene ID" value="lp_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1192"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1010"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_9"/>
    <dbReference type="OMA" id="RSHAVCH"/>
    <dbReference type="PhylomeDB" id="F9UMZ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1022-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="161" mass="18478" checksum="6B136F131B2F5462" modified="2011-10-19" version="1">MVRRVILELGLRCQVRPKKRSRIKQQDQYVRDNLLNQNFDVDAPNQVWLSDSTELAYGVNGEHKIRLGGVMDLYDRRILAYNLSITETSAAEIQVFQRSFATARNVHPMIHTDHGSAYTSGAFNHYLPANLRSHAVCHVTGHHMTMRQWNVGGMNLNYVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UN63</accession>
    <name>F9UN63_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ordered locus">lp_1277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643294.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889166.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1277"/>
    <dbReference type="EnsemblBacteria" id="CCC78652">
        <property type="protein sequence ID" value="CCC78652"/>
        <property type="gene ID" value="lp_1277"/>
    </dbReference>
    <dbReference type="GeneID" id="57024893"/>
    <dbReference type="KEGG" id="lpl:lp_1277"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1084"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039146_0_0_9"/>
    <dbReference type="OMA" id="MKFIIYQ"/>
    <dbReference type="PhylomeDB" id="F9UN63"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1094-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="351" mass="40094" checksum="54B38904230D363D" modified="2011-10-19" version="1">MTRKNIWSLLVMVALGVGISWYSLRNVKLSNLMDDILTLNWWWLLVALGCVGLYFGLEAVVVQKFVRHRYRNYRFKSALRVPLAEQLFNGITPFSSGGQPAQIFVMAQSGIDAGRASSVALMKFVVFQAMVVLNFLFAMLIGFHYLAEKLSYLSLYVLLGFLIHFAVIVGLLLVMYWYNFTKRAVKIVLIPVSWFMKAERFAKFENNISEKIDSFYEESVRMTKDWRMLVEVCIVTFLQLLFYYLIPYFIMRAMGIDDVNLIMVTSLNVLIFLVTSLFPIPGGAGGAEFGFTALFAKFIPSHSKLILAMLIWRILTYYLGLFLGMIAMAMRPEKAEEIPIAAPSRSDSQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNA9</accession>
    <name>F9UNA9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/oxidoreductase,NAD(P)-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101361.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889212.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1342"/>
    <dbReference type="DNASU" id="1062683"/>
    <dbReference type="EnsemblBacteria" id="CCC78698">
        <property type="protein sequence ID" value="CCC78698"/>
        <property type="gene ID" value="lp_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1342"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1130"/>
    <dbReference type="eggNOG" id="COG0702">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293038_0_0_9"/>
    <dbReference type="OMA" id="EFAINRE"/>
    <dbReference type="PhylomeDB" id="F9UNA9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1156-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="213" mass="23756" checksum="560F444A120D3780" modified="2011-10-19" version="1">MNTVLVIGATSPTAQAFIKLMERDYPEMTLKLFVRNRKKVPAYQKREHVIFLGDAAKYTDYVAALEDVDYIYDSVGGLSTGPYVKLLLRAIKETQATIKRIVDISAGGIYGEYLSGNLPYLSAVRTQHPQYTHDQLDKPLLFANSGIPFTIFRPGLIQNGPETKIITHGPEFRAIPESEFAINRETFARAAANALFNDDYHNQSVAISNGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UND4</accession>
    <name>F9UND4_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
            <ecNumber evidence="5">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">lp_1374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889237.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1374"/>
    <dbReference type="EnsemblBacteria" id="CCC78723">
        <property type="protein sequence ID" value="CCC78723"/>
        <property type="gene ID" value="lp_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1374"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1154"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="275"/>
        </location>
        <ligand>
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            <position position="276"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
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    </evidence>
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        <source>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="AL935263">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CCC78764">
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        <property type="gene ID" value="lp_1427"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="F9UNH5"/>
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    <dbReference type="Proteomes" id="UP000000432">
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    </dbReference>
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        <property type="term" value="F:nucleoside deoxyribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="146" mass="16608" checksum="E33D94B52F7BE2A9" modified="2011-10-19" version="1">MAQIYIASPFFSPEQVTRVTQLEEALAQNPTVTDFYSPRLHQDAQAEQFTKTWATEIFHRDMAQIAAAQVIVTVLDFEAKNLDSGTAYELGVATMRDLPIIALQEKDEAVNLMITESLHWYTKQVSDFETYDFQQLPKGDFIGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNM2</accession>
    <name>F9UNM2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101429.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889325.1">
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_1483"/>
    <dbReference type="EnsemblBacteria" id="CCC78811">
        <property type="protein sequence ID" value="CCC78811"/>
        <property type="gene ID" value="lp_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1483"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1245"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053304_2_0_9"/>
    <dbReference type="OMA" id="YMARILL"/>
    <dbReference type="PhylomeDB" id="F9UNM2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1272-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="292" mass="33268" checksum="A98CA1C70E59C49B" modified="2011-10-19" version="1">MDIKKFVARRKALQISQIKLSAGICTQATLSKFERRGRVPSLAILEQLCARLGLTVDELNEDQASSVTQMRQELDHIERQLMMEDYQVVLQALNRIAVSEIAAVPLRMQYYYLSGLLKSLINGAVSDVCFDFDQILDDLDQTHETVFTPLAYVGLGVMYSRLSELAKAQFYFEKVHQAVKQALVNGDDQDYLRLLTMIFYTAEYEATREDFTTSNGLINDGVSLCSEQHVTYYLPRLKYLATANAIQQCQPDEQIQQLLSETVAFARINHNQVVEVKAAALRRRYLQARKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNV2</accession>
    <name>F9UNV2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_1573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644304.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889405.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1573"/>
    <dbReference type="EnsemblBacteria" id="CCC78891">
        <property type="protein sequence ID" value="CCC78891"/>
        <property type="gene ID" value="lp_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1573"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1325"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_9"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="PhylomeDB" id="F9UNV2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1352-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC78891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="33733" checksum="579C32D82FF58C9F" modified="2011-10-19" version="1">MERKLIGVDLGGTTTKFAILTENGDIQQKWSIETTILDEGAHIVPNIIDSINHHIELYKMDRSQFIGIGMGTPGTVDLDNGTVIGAYNLNWKTLQPVKAQIEKGTGIKFTLDNDANVAALGERWKGAGENGSDVVFVTLGTGVGGGIIADGRLLHGIAGGAGEIGHVTVEPNGYMCTCGKKGCLEQYASATGVVHVARDMAEEFSGASKLKQLLDNGEEISSKITFDLAKEGDVLAKRVVDRVSYYLGLALANVGNTMNPSSIIIGGGVSAAGDFLLDQVISYFNQFTFPTIRDTTALKLAVLGNDAGVIGAGSLAQRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY2</accession>
    <name>F9UNY2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine betaine/carnitine/choline ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">opuB</name>
        <name evidence="7" type="ordered locus">lp_1608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644316.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889435.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1608"/>
    <dbReference type="EnsemblBacteria" id="CCC78921">
        <property type="protein sequence ID" value="CCC78921"/>
        <property type="gene ID" value="lp_1608"/>
    </dbReference>
    <dbReference type="GeneID" id="57025191"/>
    <dbReference type="KEGG" id="lpl:lp_1608"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1356"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_9"/>
    <dbReference type="OMA" id="MRYLFTH"/>
    <dbReference type="PhylomeDB" id="F9UNY2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1383-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="209" mass="22387" checksum="467EF7215F94EE76" modified="2011-10-19" version="1">MITFLQNYGMQLLVKTWQHLYISAFSLFLGIIVAVPIGILLTRVKPIANVVMSIASMLQTIPAMALLALMIPFFGIGAIPAIIALFIYSLLPILRNTYLGLEDVDPALIDAAKGMGMTGWQSIVKVELPMAAPVIMAGIRLSATYVIAWAALASYIGAGGLGDFIFNGLNLYRTDLILGGSIPVIILALIVDWLLGKLEAAVTPRTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNY8</accession>
    <name>F9UNY8_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">lp_1614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101473.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889441.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1614"/>
    <dbReference type="EnsemblBacteria" id="CCC78927">
        <property type="protein sequence ID" value="CCC78927"/>
        <property type="gene ID" value="lp_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1614"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1362"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_9"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="PhylomeDB" id="F9UNY8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1389-MON"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="190"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="195"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC78927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="408" mass="43426" checksum="060E00D5AA96DB91" modified="2011-10-19" version="1">MSIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQPVVIDEFTTTDPHHVVHVALADWTEVMILVPATANLIAKVANGLADDAATTTILATTAPKFVVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEGYSGQGRLPEPAVILAWLTDQLIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISATTHLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADHADLTLRLTETPDILKTLAARKHQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKPGVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAIADGAGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F9UNZ1</accession>
    <name>F9UNZ1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sunL</name>
        <name evidence="14" type="ordered locus">lp_1617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="5"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101476.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889444.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1617"/>
    <dbReference type="EnsemblBacteria" id="CCC78930">
        <property type="protein sequence ID" value="CCC78930"/>
        <property type="gene ID" value="lp_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1617"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1365"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_9"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="PhylomeDB" id="F9UNZ1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1392-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="171"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="260"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC78930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="447" mass="50117" checksum="BBC9C9F4021A2545" modified="2011-10-19" version="1">MSTVGNTPRWLAVAALAKIKNGAYSNLQLNQLINDHQMDRRDINLLTNMVYGVIQHRLTLEYWLTPFVRHPHQIDPWVRELLLSALYQWQYLDKIPQRAVFNETIEIAKVKGHPGIRRFVTGVLHQMDRSGLPSFDAIKNPDERLSVTYSMPIWLIQELRRQLGAEKMERILSSLNQPAKQALRVNPALSTVEDVTTALINDGLTITPSEISPLGLIATDGQAINTEAMRYGMFTVQDESAQLVVPALNPQPNDRVLDACAAPGGKTTQIAASLDAEQGGTVVALDIHANKVKLIGQNAARMHVADRVEATELDARKVETQFNAESFDRILVDAPCSGLGLMRRKPEIRYEKQLQDSLNLQRIQLAILTAVAPTLKKGGIMTYSTCTILQQENQDVITKFLADHPDFELQTTPTERDLKTDRTEKTLSIYPDDYLSDGFFIACLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP27</accession>
    <name>F9UP27_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889480.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1662"/>
    <dbReference type="DNASU" id="1061557"/>
    <dbReference type="EnsemblBacteria" id="CCC78966">
        <property type="protein sequence ID" value="CCC78966"/>
        <property type="gene ID" value="lp_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1662"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1402"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_2_2_9"/>
    <dbReference type="OMA" id="RAFSIHY"/>
    <dbReference type="PhylomeDB" id="F9UP27"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1429-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="142" mass="15979" checksum="ADF251AA57F47B7D" modified="2011-10-19" version="1">MIQLVRYSTTRGALKQIQQYQLVNVIYTATPQQVIRACKSDLERTAVMIMNGNQLVGFFCLHVGQGPLSYGETEVNTILLRALSVDDRFKHQRVASDALAELPRYLASHYPMIQTILLAVNHANHVAQHLYLTMVSLIRIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP31</accession>
    <name>F9UP31_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_1667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101498.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889484.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1667"/>
    <dbReference type="EnsemblBacteria" id="CCC78970">
        <property type="protein sequence ID" value="CCC78970"/>
        <property type="gene ID" value="lp_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1667"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1406"/>
    <dbReference type="eggNOG" id="ENOG5030PQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166074_0_0_9"/>
    <dbReference type="OMA" id="RVFTWIV"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1433-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC78970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="120" mass="13096" checksum="F7E5ECB45BB1B5B6" modified="2011-10-19" version="1">MRVFTWIVRTIVAGAVLMCVIMIGLAPQTVVTHFNSAGLADSFGSRWWLVMLPLLVVVTGEVMIKLARQKRRKLGLLQLPTLTGFEGQCLGVMVGFSVLLWVILQSEVQGRLVSGGIGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9UP86</accession>
    <name>F9UP86_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">galM2</name>
        <name evidence="1" type="ordered locus">lp_1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101525.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889539.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1731"/>
    <dbReference type="EnsemblBacteria" id="CCC79025">
        <property type="protein sequence ID" value="CCC79025"/>
        <property type="gene ID" value="lp_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1731"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1460"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_1_1_9"/>
    <dbReference type="OMA" id="AVHPCSG"/>
    <dbReference type="PhylomeDB" id="F9UP86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1488-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="337" mass="37788" checksum="96D574A6D90A7E1E" modified="2011-10-19" version="1">MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDNLADYIETPYQVGKTVGRVAGRIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRARFDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQISYHGVTTADTLFNPTCHVYFNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQETGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALAVELQTLPDAINHHGFGDVVLRAGQPRTYVNRYQYVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPE1</accession>
    <name>F9UPE1_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="4" type="ordered locus">lp_1793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640521.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889594.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1793"/>
    <dbReference type="EnsemblBacteria" id="CCC79080">
        <property type="protein sequence ID" value="CCC79080"/>
        <property type="gene ID" value="lp_1793"/>
    </dbReference>
    <dbReference type="GeneID" id="57025407"/>
    <dbReference type="KEGG" id="lpl:lp_1793"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1514"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022481_2_1_9"/>
    <dbReference type="OMA" id="SKPGFVI"/>
    <dbReference type="PhylomeDB" id="F9UPE1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1543-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="3">
        <location>
            <begin position="449"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="568" mass="64418" checksum="86299C80AD6F8AD8" modified="2011-10-19" version="1">MSFDGLFTHAMVTELRQTLVGGRISKINQPYQNELILTIRANRKNHPVLLSADPTYPRIQTTQIPYVNPAVPTNFAMMMRKYLQGAIVTDVSQVANDRVVHLTVTTRNELGDAETLTLIIEIMARHSNVILVDNQTGKIIDVIKHVGADQNRYRLLLPGATYIEPPKQDKQDPFTPNTDFHTLVTDYPNEDVLAKQLQQHYQGFGRDSAQQLAADLHQPGDLDHHYLAFLAQFDQPQATLITLPNHKTMFAAGPFDHFGKATRQFDSLSSLLDFYYADAAQRERVQQQAGNLIRVVKNNLKKNRNKLKKLEKTLANTKQADELRLKGEILTTYLHEVKRGMTEITLPDYYHDNAPLKIQLSNQLSPSRNAQKYFSRYQKQKNAVGFVGEQISLTQAEIDYLDNIQTQIELASPADITEIREELTQQGYLKQHKTKKKQRSSRKPSQPQEFTASDGTPIFVGKNNRQNDQLTLKTARKSDYWLHTQKIPGSHVIIHSDDPSDQTLTEAANLAAYFSKARDSATVPVDYVQVRRIRKPNGAKPGFVIYEGQKTLYVSPNAELVEQLTPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPF7</accession>
    <name>F9UPF7_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">lp_1814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101559.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1814"/>
    <dbReference type="EnsemblBacteria" id="CCC79096">
        <property type="protein sequence ID" value="CCC79096"/>
        <property type="gene ID" value="lp_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1814"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1532"/>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021628_4_1_9"/>
    <dbReference type="OMA" id="LIVTRIH"/>
    <dbReference type="PhylomeDB" id="F9UPF7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1559-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
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        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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            <begin position="31"/>
            <end position="54"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="186"/>
            <end position="205"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
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            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC79096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="530" mass="56097" checksum="E961DEEDFC596527" modified="2011-10-19" version="1">MIFIASAAIILPLILLGGLNLSATRGMTISALVVIITGYFFWQISPTVLTASILQAIHKALPILWILFGALLMLNCLRATGAIDRINQGFQSLSADMRLQTVLVAFLFGGLIEGVSGFGTPAMVTAPLLIALGFSPMAAVILALVADSTPAAFGAVGTPLTVGLSNVTEKASVLNLIGLRITQLDLFVGALMPAVLILILIMWFGPKAHRLKSWLSVLPWALVIGFVYSLLALLSAWLVGYEFVSIIAPLGTLVIAIITIRLHWLLPKSSQLTPWRTNGMAAQTPAPSPMNLMTAWFPYLLVVVLLLASRVVTPIKQVLTRYANLSWSHILGYSQINSDWELLYSPGTILAVAAIIGLLVQARSLKPLLPTAHSVIRSMGNTAIALGVTLIMVQVFTNSGLNQANLPSMPMYIAKFIATYLAGVWVIMAPFLGQLGAFVTGSTTVSTLTFAQIQADIAANASLKPTIILAAQLVGAAAGNMVCVHNIVAVSSVVGLSGQEGAILRKTLLPGLGYALLIGVAGWLLLRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPG3</accession>
    <name>F9UPG3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101563.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889616.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_1820"/>
    <dbReference type="EnsemblBacteria" id="CCC79102">
        <property type="protein sequence ID" value="CCC79102"/>
        <property type="gene ID" value="lp_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_1820"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1538"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_9"/>
    <dbReference type="OMA" id="QFFFVYF"/>
    <dbReference type="PhylomeDB" id="F9UPG3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1565-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="175" mass="19985" checksum="DEC0B92D1414CE29" modified="2011-10-19" version="1">MSQITTRRLTTADVNKLQQISIETFKDTFGAQNSSENMAAYLQDAYNLPKLTHELAEPESQFYFVERAGESLGYLKLNTGAAQSEAMGPDTLEVERIYIRKAFQHQGLGNQFMQQAIQIAKADHKQKIWLGVWEHNEPAKGFYAKWGFEQFSAHDFVMGDDRQTDLLMIKSLTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW4</accession>
    <name>F9UPW4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ISP1-5C</name>
        <name evidence="2" type="ordered locus">lp_2005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889767.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2005"/>
    <dbReference type="DNASU" id="1062100"/>
    <dbReference type="EnsemblBacteria" id="CCC79253">
        <property type="protein sequence ID" value="CCC79253"/>
        <property type="gene ID" value="lp_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2005"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1694"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_5_3_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1717-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="97" mass="11365" checksum="82C51C084899896A" modified="2011-10-19" version="1">MKAALGHVENVSPQLMTNIKSFIKNRQLIKNMTTGRLSNGPVEGVNRKIKQIKRTAYGYKNWQNFIYRIQIEFKIKIEKRTQFANKLDSKYNFINTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UPW9</accession>
    <name>F9UPW9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889772.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2011"/>
    <dbReference type="EnsemblBacteria" id="CCC79258">
        <property type="protein sequence ID" value="CCC79258"/>
        <property type="gene ID" value="lp_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2011"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1698"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_17_3_9"/>
    <dbReference type="PhylomeDB" id="F9UPW9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1720-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="115" mass="13404" checksum="A682EBB0BE17CC20" modified="2011-10-19" version="1">MTASPSRKQVPKMSRKTTFNERVTIVEWINKGNHSYSEAAEHFNVSYQQARYWALKAQAKGFEVLVDNRGHRKPESELTDLDKANLRIRQLESQSKDQQLLEAFIKKYQALQHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ30</accession>
    <name>F9UQ30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640763.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889833.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CCC79319">
        <property type="protein sequence ID" value="CCC79319"/>
        <property type="gene ID" value="lp_2081"/>
    </dbReference>
    <dbReference type="GeneID" id="66449853"/>
    <dbReference type="KEGG" id="lpl:lp_2081"/>
    <dbReference type="eggNOG" id="ENOG5030ANU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186804_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1780-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="68" mass="7898" checksum="6B79559CF624E195" modified="2011-10-19" version="1">MRIRRPVRFYRSFWFWLSVIFLWVSTAGFPKTLVTVGDVLCYGILFLLSCVGILGSFFVFGQAAREQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQ58</accession>
    <name>F9UQ58_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamine ABC transporter, substrate binding and permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glnPH2</name>
        <name evidence="10" type="ordered locus">lp_2111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003640791.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889861.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2111"/>
    <dbReference type="EnsemblBacteria" id="CCC79347">
        <property type="protein sequence ID" value="CCC79347"/>
        <property type="gene ID" value="lp_2111"/>
    </dbReference>
    <dbReference type="GeneID" id="57025654"/>
    <dbReference type="KEGG" id="lpl:lp_2111"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1788"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_20_4_9"/>
    <dbReference type="PhylomeDB" id="F9UQ58"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1808-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394397" evidence="8">
        <location>
            <begin position="31"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="290"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="491" mass="53848" checksum="A17FDD29C1DFD263" modified="2011-10-19" version="1">MKKRFGWFLAIIVALIMTVVPLGQTQHAQAADNSLEQIQKKGVLVMGTSPDYPPYEFQATVNGKSKIVGMDVQIGKQVAKDLGVKLKIKSMSFDSLLVALQTGKVDMIISGMNPTPSRRKNVDFTHVYYQGGYDIVINKTDKGKYKNKNSFKNGTLGAQTGTTQYNAVKNQTTAKAKGMTSQSDLILALQSHKVDGVAMEKPSAEAYVANNKSLVAIPSDFNMSSSATSSAIAFRKGSTSLVNKVNKTVDRIKKQNLVKKQYLPAAGKYLKTNTVNTSMGHYWKAFATGIEYTLIITVCSVFFGFIIGILLALARMAKGNPLKTAIRWLATAYVEFIRGTPMMVQVMFVYFGLGLFVNLPALTSGIIAISLNSGAYVAEYIRGGINSVDVGQTEAARSLGMSNGETMRYVVLPQALKNIWPSLGNEFITLIKDSSIVSIIGVTELIYQSNIVRSDTYRGVAPIVVIMVLYFILTFTASRILNYFERRMQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQG9</accession>
    <name>F9UQG9_LACPL</name>
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        <submittedName>
            <fullName evidence="5">Bacterial type II secretion/trafficking system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_2247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for transformation and DNA binding.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641549.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889972.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2247"/>
    <dbReference type="EnsemblBacteria" id="CCC79458">
        <property type="protein sequence ID" value="CCC79458"/>
        <property type="gene ID" value="lp_2247"/>
    </dbReference>
    <dbReference type="GeneID" id="57025795"/>
    <dbReference type="KEGG" id="lpl:lp_2247"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1901"/>
    <dbReference type="eggNOG" id="COG4537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_9_3_9"/>
    <dbReference type="OMA" id="ENYFNTE"/>
    <dbReference type="PhylomeDB" id="F9UQG9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1943-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016940">
        <property type="entry name" value="ComGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029928">
        <property type="entry name" value="Late_competence_ComGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0178">Competence</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="118" mass="13127" checksum="7CF2E13C84B1E495" modified="2011-10-19" version="1">MTLLMKRLMKKTAAPQRGFTLIEMVIVLAIISLLMLIVVPNLNQQRKQAAGRQQEALTEVVQNQAEMYANDTGKTVTDDDAMLEELRNKGYINDGQYKQAKSQGISPVRPQPQKVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQJ5</accession>
    <name>F9UQJ5_LACPL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bacilli</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2276"/>
    <dbReference type="EnsemblBacteria" id="CCC79484">
        <property type="protein sequence ID" value="CCC79484"/>
        <property type="gene ID" value="lp_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2276"/>
    <dbReference type="HOGENOM" id="CLU_2117920_0_0_9"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="114" mass="13378" checksum="EA29C758CCE1D277" modified="2011-10-19" version="1">MLWLHILFFMLVSYVKAIKITIKSVLLGRDRSNGTDFLMLWHLVTGLTRRRLGYKGGLLWTSTIRTFETGVCQHMKKQCKSGWICRKRLHSPGYYYECVTSKWIDCTSYGHLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQQ3</accession>
    <name>F9UQQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-Methionine-like ABC transporter,permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">lp_2351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101721.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890056.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2351"/>
    <dbReference type="EnsemblBacteria" id="CCC79542">
        <property type="protein sequence ID" value="CCC79542"/>
        <property type="gene ID" value="lp_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2351"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1987"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_9"/>
    <dbReference type="OMA" id="MTWSEMQ"/>
    <dbReference type="PhylomeDB" id="F9UQQ3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2026-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="230" mass="24818" checksum="2997FC31F69F36E2" modified="2011-10-19" version="1">MNDQGLDSYFKFANVDWGSMMSATWETIWLTIVSMVVVAILGIALGLLLYETAGSQNPLTKALNWIVALFVNVFRSIPFIILIVLLLPVTSKLVGTIIGPRAALPSLIISAAPFYARMVELAFHELDHGVIEAAESMGATRWQIIRKVLLPESMPALVSGITVTTISLIGYTAMAGAIGAGGLGNLAYQDGFQSNNNAITLVATVIIVIIVFIFQFIGDIAVRHIDKRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQS0</accession>
    <name>F9UQS0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrP</name>
        <name evidence="8" type="ordered locus">lp_2371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890073.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2371"/>
    <dbReference type="EnsemblBacteria" id="CCC79559">
        <property type="protein sequence ID" value="CCC79559"/>
        <property type="gene ID" value="lp_2371"/>
    </dbReference>
    <dbReference type="GeneID" id="57025903"/>
    <dbReference type="KEGG" id="lpl:lp_2371"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2004"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_9"/>
    <dbReference type="OMA" id="INHGIGM"/>
    <dbReference type="PhylomeDB" id="F9UQS0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2043-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="426" mass="45228" checksum="89393BD2085D7B65" modified="2011-10-19" version="1">MTKKAAFHNDEVVLDIHDRPKLGSWLGLSVQHLFSMFGSTVLVPILVGLNPGIALFSSGVGTLMYILITRGKIPAYMGSSFSFIVVMQSLMKTAGYPAIAQGTVAVGCVYLLVSLLVTLIGSDWIDKALPPIVVGPIVMVIGLSLAGTAAKDATMNGSSYDIKYFGVAMATMLLTVIFNMYLRGFMSLVPILLGIVCGYIIAVLVGIVDFSGVEKAQWFAMPAFQLPFISYHPGIYWGAILSMAPIAFVTMSEHMGHIMVLNKLTKRNFFKDPGLNHTLAGDGTASIIAGFVGGPPVTSYGENIGVLAITRVHSIYVLGGAAFFAIVFSFVGKLSALIESIPSPVIGGVSFLLFGVIASSGMRILIDNKVDFNQKRNLMIASAILVIGIGNAYLQLGSFQFSGLAVATVLGIVMNLVLPKTAVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQT8</accession>
    <name>F9UQT8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prophage P2a protein 59 extracellular polysaccharide deacetylase, lipid-anchored</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_2397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644667.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890091.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2397"/>
    <dbReference type="EnsemblBacteria" id="CCC79577">
        <property type="protein sequence ID" value="CCC79577"/>
        <property type="gene ID" value="lp_2397"/>
    </dbReference>
    <dbReference type="GeneID" id="57025921"/>
    <dbReference type="KEGG" id="lpl:lp_2397"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2022"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_2_0_9"/>
    <dbReference type="OMA" id="MSFQSHT"/>
    <dbReference type="PhylomeDB" id="F9UQT8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2062-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394298" evidence="2">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="122"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC79577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="283" mass="31628" checksum="7F6CCB42FC2672D4" modified="2011-10-19" version="1">MHMRGINFVLGLGVALGLLAGCQAASPATKQASSQSSKTSAKSVHSSAKHQAQARPYQHWHTVKDVHLPILMYHSISSGNQLRVPAKEFQTEMTYLKAHGYRTLTANEAVYALKHRRIPQKKIVWITLDDSYKDNMTAAWPILKQTHQHATINFITGFTHKKNHLTLADAKRMQASGNIDFQSHTVRHLDLNNLTYQVQLTELSSSKKWLDHNLQQNTQVICYPAGRANQQTIKADKQAGYQYALSTAPGIATSTQNPYNLTRQRVVPGMSLTAFQTLLTSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU0</accession>
    <name>F9UQU0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prophage P2a protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101732.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890093.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2400"/>
    <dbReference type="EnsemblBacteria" id="CCC79579">
        <property type="protein sequence ID" value="CCC79579"/>
        <property type="gene ID" value="lp_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2400"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2026"/>
    <dbReference type="eggNOG" id="ENOG5032EER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2330232_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2064-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="98" mass="11238" checksum="AF18969463A6E9E5" modified="2011-10-19" version="1">MHTLLGLGWDEWGSIVAIVASICVLANWILNKTVRVPLNDLGKRLSRFTDESLKVRQQNADTMNAIENRVIKVEGRLDGHDIELKHLYEKEVKQNEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9UQU8</accession>
    <name>F9UQU8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prophage P2a protein 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101740.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890101.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2408"/>
    <dbReference type="DNASU" id="1062476"/>
    <dbReference type="EnsemblBacteria" id="CCC79587">
        <property type="protein sequence ID" value="CCC79587"/>
        <property type="gene ID" value="lp_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2408"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2034"/>
    <dbReference type="eggNOG" id="ENOG50333IU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081264_0_0_9"/>
    <dbReference type="OMA" id="NEDGSHW"/>
    <dbReference type="PhylomeDB" id="F9UQU8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2072-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008841">
        <property type="entry name" value="Siphovirus-type_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05709">
        <property type="entry name" value="Sipho_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="298" mass="33281" checksum="4266EF195C1C7484" modified="2011-10-19" version="1">MKVFSERADKPHAYLFGEYTNPLGFDPVELALSEDGQAWQSIFDDPNLSNVYLVDFDWLPPVIADTYRTAGTRDGQQLANSRLDQRDIVLKFIAYCRGDADEKLTFQSLSNFLIRRHNYWVAFDNDGSRMYHVREKTITAEYYGDKMMMITVTLNNFTGVAQSIMPSAHINEMPNIGLGLPTDIVNYVFRTSEFDVNNIGELPVDPLVQGDYFDITLTGIGSPTIANTTTGDAITCTKSLTTGDTFKLIGVNPQINGQAAGINTDNGIIRLASGNNHFKITGCQDLNCTVNFYFKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR85</accession>
    <name>F9UR85_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">asd2</name>
        <name evidence="12" type="synonym">asd</name>
        <name evidence="14" type="ordered locus">lp_2570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101830.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890238.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2570"/>
    <dbReference type="EnsemblBacteria" id="CCC79724">
        <property type="protein sequence ID" value="CCC79724"/>
        <property type="gene ID" value="lp_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2570"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2160"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_9"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="PhylomeDB" id="F9UR85"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2216-MON"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC79724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="353" mass="38257" checksum="18970EFAF090E080" modified="2011-10-19" version="1">MSGYNVAIVGATGAVGARMIKMVEQTSLPVNSVKLLASSRSAGKQLQFNGQALTVEETVPESFEGIDLSLFSAGGSVSKKFAPEAVKRGAVVVDNTSAFRMDPKIPLVVPEVNPEALKLHHGIVANPNCSTIQMVVALEPVRKAFGLKRVIVSTYQAVGGAGNRALKELHDEAEAYLKGEEMEAHILPVAGDKKHYPIAFNALPQIDVFEEDGYTHEEWKMIHETKKIMCGGDMDSKDIKVTATCVRIPVPVSHSESVYFEVEDPKATVKGIQDALAAAPGVVLQDDPDNQIYPQAHNAEGSKDTFVGRVRPDQETPQAFHMWNVSDNLLKGAAWNSVQIAETMDKMGLLHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9UR99</accession>
    <name>F9UR99_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family 1 protein</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101839.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890252.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2590"/>
    <dbReference type="DNASU" id="1062814"/>
    <dbReference type="EnsemblBacteria" id="CCC79738">
        <property type="protein sequence ID" value="CCC79738"/>
        <property type="gene ID" value="lp_2590"/>
    </dbReference>
    <dbReference type="GeneID" id="57025999"/>
    <dbReference type="KEGG" id="lpl:lp_2590"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2174"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_5_9"/>
    <dbReference type="OMA" id="DRAVEHQ"/>
    <dbReference type="PhylomeDB" id="F9UR99"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2229-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="186" mass="20059" checksum="4DE473BF9091A34C" modified="2011-10-19" version="1">MTTNSPLEAIMNARHSVRQYDGQTKIGREEMAAMLQTAFLAPTALNQQPIRALVIEDAALRQRLCAATGNTSQLTTASAVVLFVLDRENQHQAPAFQASQGQQFDTGDETIGALDAGLIAMQFMLVAKDHGFDTNPMTGFDAAGFTSILELDAQRYRPLLLVSIGKAAVAGKPADHQPLATLVDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA3</accession>
    <name>F9URA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional protein: transcription regulator sugar kinase, ROK family</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_2595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101842.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890256.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2595"/>
    <dbReference type="DNASU" id="1062821"/>
    <dbReference type="EnsemblBacteria" id="CCC79742">
        <property type="protein sequence ID" value="CCC79742"/>
        <property type="gene ID" value="lp_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2595"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2178"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_9"/>
    <dbReference type="OMA" id="WILERRP"/>
    <dbReference type="PhylomeDB" id="F9URA3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2233-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC79742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="320" mass="34990" checksum="09C2171D395FC9D1" modified="2011-10-19" version="1">MSEEPRYLAVDVGGTNLKYALINRSGQMIKKSRMETPHEGLTQFLEAIEKISDKLKGQLNGVAFSTPGRVDTTTDTIYCRNSTLPYLNEVCLPRKLQKLGLPISVENDGKSAALAESWLGNLNDVKNGMAIVLGTCVGGGIMLDGHLWAGSRRLAGEVSLMPADQTNLADDGLFGKTGSAVRMIEAVNTVIGASCLTDGHCAFAAINAGQAQATQIFRQYAREVAALILNVQTVLDLDRYVIGGGISFQPILIDEINRQYDWILERRPWVKSTIARPEILSSRFHNDANLYGALYRLFNKLDAKHDVPIDLDNLLVNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9URA8</accession>
    <name>F9URA8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tal1</name>
        <name evidence="2" type="ordered locus">lp_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
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            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
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                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
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            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
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        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
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            <end position="52"/>
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    <sequence length="94" mass="10699" checksum="8B5603AA24F27591" modified="2011-10-19" version="1">MKRRLIAAPTGLLLAGWLIGWGLQAMHQPMGTAWTAYAFTLLILYTILATFITSMADAYQGKHGRTVPEKQFYWYMCTLSVILTILAIYWMAHN</sequence>
</entry>
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        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
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                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Azg-like_bact_archaea"/>
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        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="427" mass="45025" checksum="C56B72E4FC039DD8" modified="2011-10-19" version="1">MRENRTSVRRELIGGLTTFLAMSYILAVNPELLGSTGMSKTAVFTATILAAIVGCLLMGLVANFPVALAPGMGLNAFFTYTVVQEWHIPWQTALAGVFVAGILFILLTLSKLRDKLINLIPSALKYAVSAGIGLFIAFSGLQTSGIIVANKSNAVALGNLHSPTVLLAIFGIIVGIMLVTANVTGGIFWGMFITAAVGMIFGIIPLPTGIISGVPSVQPIFGQAVTHLGNINSFQMIIVILTFFIIGLFDTSGTLVGVATEAGMVDKESGEVKGVGKALFSGALATTLGAVFGTSPTTAYVESTSGVAVGARTGLSSVFVALLFAIAAFFSPILTVITSAVTASALIIVGILMLSNVQYIDWTKFEIAVPAFFTMIMMLLTYSISEGLAVGFIFYPITMTVKGRWREVNALMWTMMVVFILYFAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT4</accession>
    <name>F9URT4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642108.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890437.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2826"/>
    <dbReference type="DNASU" id="1063184"/>
    <dbReference type="EnsemblBacteria" id="CCC79923">
        <property type="protein sequence ID" value="CCC79923"/>
        <property type="gene ID" value="lp_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2826"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2364"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_1_9"/>
    <dbReference type="OMA" id="GYIAKPN"/>
    <dbReference type="PhylomeDB" id="F9URT4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2420-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="179" mass="20157" checksum="4E3840BF057461D1" modified="2011-10-19" version="1">MRKVQFYGAISIDGCLATKDNRLDWLFKTAGANDAPTEAFMQQVDTAIMGRHTYEYTMEQTTDQLINPYNPATHNIVMTSHPHTGDERTQFTNTPVTKIVEDLRRTAGKNIWIVGGAGVLMPLLAADLVDELYIQIAPVILGDGIPLFKAIDQQQRFELVDTNRYGQLAEVHYQRLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F9URT5</accession>
    <name>F9URT5_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">napA3</name>
        <name evidence="7" type="ordered locus">lp_2827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101927.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890438.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2827"/>
    <dbReference type="EnsemblBacteria" id="CCC79924">
        <property type="protein sequence ID" value="CCC79924"/>
        <property type="gene ID" value="lp_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2827"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2365"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_9"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="PhylomeDB" id="F9URT5"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2421-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004771">
        <property type="entry name" value="K/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00932">
        <property type="entry name" value="2a37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="9"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC79924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="388" mass="40796" checksum="C0272F88DD84912E" modified="2011-10-19" version="1">MDYVGSLALILIVTAVAGHLSVRMGLPAVIGQLLSGIILGPAVLGWVSATSFIKDFAELGVIILMFMAGLESDLKLLKKYWRPSLLVAVLGVILPVAVIDWCSQLFHLNATESLFLGVTFAATSVSISVAVLKELGALDGKEGTTILGAAVVDDVLAVLILSLMISLFGSEVSGGGSHASTNLGLSLAIQLAFFVALYFVVKWVVPHLMAVGNALLVPTSITLMSLVICFGLSYLADAIGLSAVIGAFFAGIAVGQTDYHEVIDEHIQPIGNAVFIPVFFVSIGLNMSFNGFLNDFWFIVVITVAAIATKLIGAGVGARLAGFNWLSGYEIGAGMVSRGEMALIIAQIGYQGKLLSADRYSAVITAIILTTLIAPLLLRQAVKRQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9URV0</accession>
    <name>F9URV0_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ogt</name>
        <name evidence="2" type="ordered locus">lp_2848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644756.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890453.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2848"/>
    <dbReference type="EnsemblBacteria" id="CCC79939">
        <property type="protein sequence ID" value="CCC79939"/>
        <property type="gene ID" value="lp_2848"/>
    </dbReference>
    <dbReference type="GeneID" id="57026204"/>
    <dbReference type="KEGG" id="lpl:lp_2848"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2381"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_9"/>
    <dbReference type="OMA" id="RFHIAAT"/>
    <dbReference type="PhylomeDB" id="F9URV0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2436-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC79939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18613" checksum="0C7B84C2A30215F0" modified="2011-10-19" version="1">MHLTLTQTTINQQTYWLGTTPTGLAFVGRANGPRDEWQAFFKSANIHYDQQANQQACQELHDYLTGQRQHFDIPLDQTTGTPLQHQVWQALTRIPYGQTATYSQLATMINHPTAVRAVASAVGQNPLLIVIPCHRIRRKDGQLGGYRGGLPMKRALLALENARLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9US30</accession>
    <name>F9US30_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890533.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2952"/>
    <dbReference type="EnsemblBacteria" id="CCC80019">
        <property type="protein sequence ID" value="CCC80019"/>
        <property type="gene ID" value="lp_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2952"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2463"/>
    <dbReference type="eggNOG" id="ENOG5030A7H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2508591_0_0_9"/>
    <dbReference type="OMA" id="MKSEVQG"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2515-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015046">
        <property type="entry name" value="LciA_Immunity-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08951">
        <property type="entry name" value="EntA_Immun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0079">Bacteriocin immunity</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="88" mass="9906" checksum="5A944FCD5B064BB2" modified="2011-10-19" version="1">MCNVKSEVQGIIQDLYQELAPTAANQEIRAALLKAHQQLKQAPQLDHALIKRLTNDVTYNIFTKQLRLTPTENLLVSELLSVSHRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9US77</accession>
    <name>F9US77_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_0057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643641.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888138.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0057"/>
    <dbReference type="EnsemblBacteria" id="CCC77624">
        <property type="protein sequence ID" value="CCC77624"/>
        <property type="gene ID" value="lp_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0057"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.46"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="PhylomeDB" id="F9US77"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-46-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="295" mass="32706" checksum="8A430A6F4BA4B403" modified="2011-10-19" version="1">MNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHRAQLVTTAAGRTLYIKSKQLLKDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFISVDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERATDLRVSILEEHQMQVLANVNSPLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQNVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9US81</accession>
    <name>F9US81_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adc</name>
        <name evidence="4" type="ordered locus">lp_0061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641674.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888142.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="SMR" id="F9US81"/>
    <dbReference type="STRING" id="220668.lp_0061"/>
    <dbReference type="DNASU" id="1061220"/>
    <dbReference type="EnsemblBacteria" id="CCC77628">
        <property type="protein sequence ID" value="CCC77628"/>
        <property type="gene ID" value="lp_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0061"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.50"/>
    <dbReference type="eggNOG" id="COG4689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007961_0_0_9"/>
    <dbReference type="OMA" id="REGACMP"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-50-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC77628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="281" mass="30748" checksum="9B6843EB80A6B9BC" modified="2011-10-19" version="1">MASFIASDQDVKNFLTAPSMNDQEGIGFAYATDEAVLKALIPAPLKLMAPVVCGYVVHMGKPTFSAPYLEESLFALVSYKDKMMGAYPINLLLHGPGAESGVIAGREGAGIPKKLADDIELRRNDNSATATVERHGKTLLNVSWTAGELNDPSIMKQFAGQLALGKEAEMNSFFYKYDIDQHEDGTNHFSNVQLVATQLRSLADQVEPGNLSIQLESTDDDPFGELKVLKPLGAAWFHFDTSVMFNTLKLDEVDAATTMPKLLTGRYDRSFFNPKAATYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F9USA3</accession>
    <name>F9USA3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system N-acetylglucosamine-specific EIICBA component</fullName>
            <ecNumber evidence="16">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pts22CBA</name>
        <name evidence="16" type="ordered locus">lp_2969</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="16"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101986.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890547.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2969"/>
    <dbReference type="EnsemblBacteria" id="CCC80033">
        <property type="protein sequence ID" value="CCC80033"/>
        <property type="gene ID" value="lp_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2969"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2478"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_1_3_9"/>
    <dbReference type="PhylomeDB" id="F9USA3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2529-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010974">
        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="403"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="528"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCC80033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="660" mass="70429" checksum="7FB9360AA818FD81" modified="2011-10-19" version="1">MKNYLQRMGRSLQLPVAVLPAAALLVGIGNWWASASNDIVAHFLQAGGNAVLSQLPLLFAVGLALGMSKDKDGAAALAGLVAFELPTNVLKPESVATLLNIKVATVNPAFGQIGNVFIGIISGLIAAALYNRFHETKLPMALSFFSGKRLVPILAALTMLLVSVALLIVWPPVYDALVTFGKFIVGLGAVGAGLYGFFNRLLIPTGLHQALNSVFWFDVAGINDIGKFLAHKGIKGVTGMYQAGFFPVMMFGLPAGAYAIYRNALPERKVETASLMMAGAFASFFTGVTEPLEFSFMFVAWPLYVLHAIFTGLSLAFAAFMHWTAGFAFSAGLVDYILSLKNPIANQPLMLILQGLVLAVIYYFGFDFAIKKFHLMTPGREPVTADDADDLAIATDADDDKYTRQAKQIYAALGGADNLTVVDNCTTRLRLQLADTSTINEAAIKHSGAAGINKLDDHNLQIIIGTEVQFVADALSRLKLTNAPITKTTTSNEAVATAPTATNITSGVTTDFYSVANGQYVDIENVDDDTFAKKMLGDGFAIDPADGTITAPVDGTVSTVFPTKHAIGFKTDSGLEILLHMGIDTVELNGAPFEVLVQTDQPIHHGEVVAKADLAAIKAAGKATTMMVIITNMDAVNLMKFKMLTNQVKVSDEIMLVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F9USB3</accession>
    <name>F9USB3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter,ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livE</name>
        <name evidence="5" type="ordered locus">lp_2981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646064.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890557.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_2981"/>
    <dbReference type="EnsemblBacteria" id="CCC80043">
        <property type="protein sequence ID" value="CCC80043"/>
        <property type="gene ID" value="lp_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2981"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2488"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="PhylomeDB" id="F9USB3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2538-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="234" mass="25338" checksum="7F97B8585B504D37" modified="2011-10-19" version="1">MLKVRDLVVNYGAIQAVKGVSFDVQQGEIVTLIGANGAGKSTLLHTISGLMRPVSGSIHYLDQPIQKTAAPKIVRAGISQVPEGRHIFPGLSVQENLQMGAFLRQDRGQLAQTYQQVYDYFPILKKRRHQDAATLSGGEQQMLAMGRALMAQPKLMLLDEPSMGLAPIFINEIFEIIKAINQAGTTVLLIEQNANQALKIADRGYVLASGQVKLSGRGSELLANSEVQKAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9USD4</accession>
    <name>F9USD4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">lp_3006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102002.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890578.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1063514"/>
    <dbReference type="EnsemblBacteria" id="CCC80064">
        <property type="protein sequence ID" value="CCC80064"/>
        <property type="gene ID" value="lp_3006"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3006"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2509"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975867_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2558-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="273" mass="30562" checksum="A1F2A3CB88144F3A" modified="2011-10-19" version="1">MQIDKQQVGNRIHQLRIAAGLSMAKLASAIGLAGKSTINDWEKGRTLANADRLAKVAAYFDVSTNYLLYGSLTEYVTAVFQNGGLNHSEFNVLLWEYVDLTTTNPNILSSDLFSSASQTEQGVSDPTKIAAALITPTINNAIRQIVPEIVQHYQQTTTYPEPQAVIQAGCYVFRHRIQIIRRTFTGKYNRIVRLLDNVDLYEKLQPDDDLKAYLNQTTGPKTQVQNGYSLDEKYQRQMNKVITEFHQALNRINDAYQAELMACGQGQAHSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9USI4</accession>
    <name>F9USI4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein, CscA/DUF916 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">lp_3066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80114.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3066"/>
    <dbReference type="EnsemblBacteria" id="CCC80114">
        <property type="protein sequence ID" value="CCC80114"/>
        <property type="gene ID" value="lp_3066"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3066"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2561"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_1_0_9"/>
    <dbReference type="OMA" id="MNIANQY"/>
    <dbReference type="PhylomeDB" id="F9USI4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2607-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF916"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394411" evidence="2">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="3">
        <location>
            <begin position="179"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC80114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="354" mass="38815" checksum="D2AC55B8BE7FF069" modified="2011-10-19" version="1">MQLLKRIMVIVGTLILGLQVSSVSGLAASNASSSSSKTTQSNDIGFSVAAKIPNNQIDQHNSYFDLKMTRGRQQQIQTTIYNVTNADIKVQTAIHTAYTNGNGIIEYVTPTKSYDPSLKYRMDQITKIQGPTTITIPANGSKVVTATVTMPKQAVNGVILGGWYFKRVANKVTGSVKGSMNIANQYSYVIGLKYTAGIVPQPQLKLDTITAGMQNYRRGVFPQLRNVTAVIVPKLTITARLTSKNSGKVIKNFTQKNVQLAPNSVYKVPILTGTNRLQAGSYHVRLVAKNTDHRWVFDKDFVISTAAADKYNQASVDDSGMSVGWFILFGALGMLIIGLIGLLIFFWIKKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Cell surface protein, CscB family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">lp_3073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642324.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890634.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3073"/>
    <dbReference type="EnsemblBacteria" id="CCC80120">
        <property type="protein sequence ID" value="CCC80120"/>
        <property type="gene ID" value="lp_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3073"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2567"/>
    <dbReference type="eggNOG" id="ENOG50309JF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067278_5_0_9"/>
    <dbReference type="OMA" id="WSLNTAP"/>
    <dbReference type="PhylomeDB" id="F9USJ0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2613-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388124" evidence="1">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="202" mass="20464" checksum="89F1296EE4EE17F0" modified="2011-10-19" version="1">MKKTLLGLLFSAALIATSGLTASAADTPQTSNGTVGFTGGDITIDNGDTDLAGASLDFGTNQITAATKDDNYDNTNKSAAVSVVDLRGTAAGWDLRVKQNDVFKNDKAVANKELTGAILTLNGVLDSNASTTGADATANTGVALDTLNSDKVLMTAAVGKGNGKNVADIAKSQLMVPKTTARATGSYSTTLTWSLNTAPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9USQ3</accession>
    <name>F9USQ3_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890697.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3144"/>
    <dbReference type="EnsemblBacteria" id="CCC80183">
        <property type="protein sequence ID" value="CCC80183"/>
        <property type="gene ID" value="lp_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3144"/>
    <dbReference type="HOGENOM" id="CLU_2193617_0_0_9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2676-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="108" mass="11508" checksum="D73BBBE86A136FB3" modified="2011-10-19" version="1">MVNLTGAQTLAASYQVVKRGGRLVSVNGVPDKKQAAALGITAVYALGDLSEDARKAILDLYQQGQLTVTVSKAYPFTLAAVKQAHLDFEQGGNQGKRVIVFDQETTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9UST7</accession>
    <name>F9UST7_LACPL</name>
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        <submittedName>
            <fullName evidence="3">Phosphomethylpyrimidine kinase &amp; hydroxymethylpyrimidine kinase</fullName>
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            <ecNumber evidence="3">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD</name>
        <name evidence="3" type="ordered locus">lp_0114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="3"/>
    <dbReference type="EC" id="2.7.4.7" evidence="3"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646310.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888182.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0114"/>
    <dbReference type="EnsemblBacteria" id="CCC77668">
        <property type="protein sequence ID" value="CCC77668"/>
        <property type="gene ID" value="lp_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0114"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.92"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_0_9"/>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="PhylomeDB" id="F9UST7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-90-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC77668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="274" mass="28324" checksum="45A9973D198AA840" modified="2011-10-19" version="1">MNEFPQVATIAGTDSGGGAGVMADLKTMQARHVFGTAVVVAVTAQNTLGVQDFMAMPTKLIDEQFASLAADLDIRACKTGMLADAEHVHAVVENLKRVDFGPLTVDPVMIAKGGAALLAADAIKTVRDELLPLATVVTPNLPEAERLTGQAITSNQAMVTAGHALQGLGADNVIIKGGHGDNPDLANDFVLLADGTAFWLSAPRIDTVRTHGTGDTLSACITAELAKGRSMAAAIKTAKAYVAGTIQDGIQVGHGHGPLNHWATPSEQVIVHDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY3</accession>
    <name>GLPF2_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol uptake facilitator protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpF2</name>
        <name evidence="6" type="synonym">dhaP</name>
        <name evidence="6" type="ordered locus">lp_0171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Biochem. J." volume="454" first="559" last="570">
            <title>Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria.</title>
            <authorList>
                <person name="Bienert G.P."/>
                <person name="Desguin B."/>
                <person name="Chaumont F."/>
                <person name="Hols P."/>
            </authorList>
            <dbReference type="PubMed" id="23799297"/>
            <dbReference type="DOI" id="10.1042/BJ20130388"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to urea and D/L-lactic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641766.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888228.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9USY3"/>
    <dbReference type="SMR" id="F9USY3"/>
    <dbReference type="STRING" id="220668.lp_0171"/>
    <dbReference type="EnsemblBacteria" id="CCC77714">
        <property type="protein sequence ID" value="CCC77714"/>
        <property type="gene ID" value="lp_0171"/>
    </dbReference>
    <dbReference type="GeneID" id="57027001"/>
    <dbReference type="KEGG" id="lpl:lp_0171"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.139"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_9"/>
    <dbReference type="OMA" id="FTSHHYY"/>
    <dbReference type="PhylomeDB" id="F9USY3"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-136-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000441643" description="Glycerol uptake facilitator protein 2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA 2" evidence="5">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23799297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CCC77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="235" mass="24998" checksum="6B11997E99E37B9D" modified="2011-10-19" version="1">MHGFLGEFLGTMVLIVFGVGSGAAMNLKGNYARHQNWTFICLAWGLAVTFGVYVAGQFGSDGHLNPAVTVGFALFGYLPMANVWPYLLGQFLGAFIGAVIVIIQYYPHFQAAKTAADGNQVGIFATGPAISNPVFNFLSETIATFFFIFVLLNLGNFTQGLKPLMVGLLIVVVGQTLGGTTGFAINPARDWAPRLAYTILPVPNKGLANWGYAWVPMFGPLLGGILAAGLETIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9USY9</accession>
    <name>F9USY9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltodextrin ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdxG</name>
        <name evidence="7" type="ordered locus">lp_0177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641772.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888234.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0177"/>
    <dbReference type="EnsemblBacteria" id="CCC77720">
        <property type="protein sequence ID" value="CCC77720"/>
        <property type="gene ID" value="lp_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0177"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.145"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="OMA" id="NTYLMYG"/>
    <dbReference type="PhylomeDB" id="F9USY9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-142-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC77720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="294" mass="33152" checksum="134F567978493818" modified="2011-10-19" version="1">MDNAQAVAPKNANSKQNSARRHRFWKEFFTYLYMVILGIIIIYPVLITFITAFKDANVQAFVLDFGGKWTLVNFKNLFTQTLYGSWYLNTMIISVSCMVIQVIVVTLAGYVYSRYRFAGKKFSLTFFIVIQMVPTMAALTAYYVLANMLNALDHYWFLTAIYIGGGIPQNTWLMKGYFDNVPYDLDESAKLDGAGNFKIFWSIVLPLVKPMIAVQALWAFMSPVQDYLMAKFLLTSESHYTVAVGLQTFINNAQNQQVVLFSAGAILVALPIAALFFYLQRFFVSGLLAGGSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT07</accession>
    <name>F9UT07_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">lp_0200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100914.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888252.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0200"/>
    <dbReference type="EnsemblBacteria" id="CCC77738">
        <property type="protein sequence ID" value="CCC77738"/>
        <property type="gene ID" value="lp_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0200"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.164"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="OMA" id="GRESDYD"/>
    <dbReference type="PhylomeDB" id="F9UT07"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-160-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389020" evidence="9">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="10">
        <location>
            <begin position="87"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="553" mass="60991" checksum="ABB61ACD2582B66D" modified="2011-10-19" version="1">MKWKVMLTTATAAASTGLLLAACSQGQSKSDNAGNLRAGMAQKQVLNWSENGSELTTLDTSLVTDSISANMINNTMEGLYRIGNNNKITPGIATHTVISKDKKTYTFTLRKDAKWSNGDPVTAQDFVYSWRRTIDPKTASQYAYLYSGIKNADQITNGKAKANSLGIKADGKYKLTVTLDKPMAYFKLLMGFAIFFPQNQHAVQKYGKDYGTTATKMVYDGPFTMKGWKGTNTTWSLNRNPKYWDKKHVYLEKINDQVVKSTTTGFNLFQSNKLDMATLSGEQVKNEKNNPKLVLRKTSRLNYLEFNQKKVPALANAKLRQAMSLTIDRHQLVTDVLADGSAVPKGFVTTGLATDPTTGEDFATENAVSAATTQDTAKAKKLWAEGLKETGKKSLTLTLTHDNIDQTKETAEYVQGQLEKELPGLKITDITLPFKNRLARETSGNFQLAISGWQADFADPISDLGILTSTNDYNFGKWKNADYDAAVKQAEQSTDPTVRWTALGKAEKIIGTDEGVAPLTQTTLAQMVNPKLKGLIYNTSGTNYNFKDAYMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UT64</accession>
    <name>F9UT64_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagD1</name>
        <name evidence="2" type="ordered locus">lp_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.39" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646390.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888309.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0267"/>
    <dbReference type="EnsemblBacteria" id="CCC77795">
        <property type="protein sequence ID" value="CCC77795"/>
        <property type="gene ID" value="lp_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="66448363"/>
    <dbReference type="KEGG" id="lpl:lp_0267"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.222"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_2_9"/>
    <dbReference type="OMA" id="VVYFPYT"/>
    <dbReference type="PhylomeDB" id="F9UT64"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-217-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006409">
        <property type="entry name" value="G3P_cytidylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01518">
        <property type="entry name" value="g3p_cytidyltrns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="134" mass="15809" checksum="8217B2006A581FF0" modified="2011-10-19" version="1">MKRVITYGTFDLLHYGHIELLKRAKSLGDYLIVALSTDEFNWDSKQKKAYFSYEKRKALLEAIRYVDLVIPEKSWDQKVSDVKLYQIDRFVMGDDWTGKFDFVGEQTDAEVIYLPRTPEISTTKIKQDLNFNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTH4</accession>
    <name>F9UTH4_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">qacH</name>
        <name evidence="6" type="ordered locus">lp_3285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642504.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890806.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3285"/>
    <dbReference type="DNASU" id="1062766"/>
    <dbReference type="EnsemblBacteria" id="CCC80292">
        <property type="protein sequence ID" value="CCC80292"/>
        <property type="gene ID" value="lp_3285"/>
    </dbReference>
    <dbReference type="GeneID" id="57026555"/>
    <dbReference type="GeneID" id="66450820"/>
    <dbReference type="KEGG" id="lpl:lp_3285"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2742"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_0_2_9"/>
    <dbReference type="OMA" id="KWKPSAL"/>
    <dbReference type="PhylomeDB" id="F9UTH4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2780-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="102" mass="11072" checksum="959EB56E5EABC921" modified="2011-10-19" version="1">MAYGLLFGGIFMEVLGSFFLKRANGFRNLIPTIMVLVGYFSSLVLVTLAMQRLPLGVTYAMWAGLGTFATVILAVVVYRERLSLSRLSGLIAIVVGAILLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTI1</accession>
    <name>F9UTI1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="2">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tag3</name>
        <name evidence="2" type="ordered locus">lp_3293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642511.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890813.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3293"/>
    <dbReference type="EnsemblBacteria" id="CCC80299">
        <property type="protein sequence ID" value="CCC80299"/>
        <property type="gene ID" value="lp_3293"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3293"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2749"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_9"/>
    <dbReference type="PhylomeDB" id="F9UTI1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2787-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="175" mass="19379" checksum="201EFA4880816779" modified="2011-10-19" version="1">MISPDDFDDITANGVKDYDAYFGTPTYDDHVLFELLVVGILQVGLGWRVAASQLPVLRQHMAGLRVDAVAALDEPDFERLMLTPKVMHNGRKLRAIIQDARAIQQLQAEYGSFSNYLWAFVDATPIIMPAPDDELPTRSPLGARVAKDLHRHGLTFVGPVVTHMFLLAAGLIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTL6</accession>
    <name>F9UTL6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylglycerophosphatase</fullName>
            <ecNumber evidence="2">3.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pgpA</name>
        <name evidence="2" type="ordered locus">lp_3342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890848.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3342"/>
    <dbReference type="EnsemblBacteria" id="CCC80334">
        <property type="protein sequence ID" value="CCC80334"/>
        <property type="gene ID" value="lp_3342"/>
    </dbReference>
    <dbReference type="GeneID" id="57026597"/>
    <dbReference type="GeneID" id="66450860"/>
    <dbReference type="KEGG" id="lpl:lp_3342"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2786"/>
    <dbReference type="eggNOG" id="COG1267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2823-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026038">
        <property type="entry name" value="Put_PGPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019587">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PgpA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC80334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="166" mass="18180" checksum="06BAB1169BB853E5" modified="2011-10-19" version="1">MEKPTFKYPDKAAYEFVIQALAAKGITYHEIAHITYNLQTKYVPNLTIEECEMETQEVLHKRELLNNAMVALELDRLATEGQLNEPLQSIIASDAGVFGVDEGLALNMANIYGTIGVTNYGYVDKVKEGVIKKLDTDKSGVVNTFIDDLVGAIAAAVAAKIAHKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTN9</accession>
    <name>F9UTN9_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp2</name>
        <name evidence="8" type="ordered locus">lp_0283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643714.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888323.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0283"/>
    <dbReference type="EnsemblBacteria" id="CCC77809">
        <property type="protein sequence ID" value="CCC77809"/>
        <property type="gene ID" value="lp_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0283"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.237"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="OMA" id="FTRTEFA"/>
    <dbReference type="PhylomeDB" id="F9UTN9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-231-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC77809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="234" mass="26804" checksum="7E61E00516A93562" modified="2011-10-19" version="1">MKNTILIVEDEGSLSGYLTKELQFEDFNVLVAANGLAAMETYQAHQNELLLILLDWMLPKLDGMEVLRRIRKHDQVPVIIMTARDYVGDKVAGLDNGADDYITKPFEIEELLARIRVIQRRIENQVEPNQVYQLDDVQLDTKAHRVTNGQEEVTLTHREYDLLQFFLAHPDEVFTRDDLLDQVWGADFLGQQNVVDVYVGYLRNKITTTGASPLIQTVRGVGYKLREPMSDAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTQ4</accession>
    <name>F9UTQ4_LACPL</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">lp_0299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
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            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641873.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888338.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0299"/>
    <dbReference type="EnsemblBacteria" id="CCC77824">
        <property type="protein sequence ID" value="CCC77824"/>
        <property type="gene ID" value="lp_0299"/>
    </dbReference>
    <dbReference type="GeneID" id="57027111"/>
    <dbReference type="KEGG" id="lpl:lp_0299"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.252"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="OMA" id="FNWPGHP"/>
    <dbReference type="PhylomeDB" id="F9UTQ4"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-246-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC77824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="219" mass="24740" checksum="AFEB29E210F99981" modified="2011-10-19" version="1">MLKVNDLGYWYDRQENSLFENVNLEFKSGTSYAIVGQSGSGKTTFLSLLAGLDKPRAGQIELNGEPINKIGLTNYRKSKVAIVFQSYNLLTYMSPLNNLMTAMAITNSEHRGDKDYAMKMLRRLGITDDQMKKNVQRLSGGQQQRVAIARTMVCDAKLVVADEPTGNLDEENTKYVIDQFQKIAHEQKKCVIIVTHEPDVADVCDHSYRLEKHKFVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTR1</accession>
    <name>F9UTR1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641880.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888345.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0307"/>
    <dbReference type="EnsemblBacteria" id="CCC77831">
        <property type="protein sequence ID" value="CCC77831"/>
        <property type="gene ID" value="lp_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="57027118"/>
    <dbReference type="KEGG" id="lpl:lp_0307"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.260"/>
    <dbReference type="eggNOG" id="ENOG50338HP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223436_0_0_9"/>
    <dbReference type="OMA" id="VGHYNYF"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-253-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="238" mass="27663" checksum="C786685DA6980C82" modified="2011-10-19" version="1">MKTKLTKQLESTLYQYCLEQGAYVVEEVAMPADKGIVDTLSYQQLPDGQIEWRCYELKVTKADFHSKAKLSFIGHYNYFVLPQQLYLEVQSEIPDHIGVLIYRAFDQRALELAPQPLRTPGFLTVAKKAQRQDLQVEQTPLISHFITSLFREVDKAKRVKKGLQLYSDDQLFKELRKRARTGYDVYDPEQNLYDRFIDDTQNDAVTALQTELDARNAEYQALKLKYQALTAPDLRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9UTU2</accession>
    <name>F9UTU2_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_0340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011100969.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888376.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0340"/>
    <dbReference type="DNASU" id="1062137"/>
    <dbReference type="EnsemblBacteria" id="CCC77862">
        <property type="protein sequence ID" value="CCC77862"/>
        <property type="gene ID" value="lp_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_0340"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.290"/>
    <dbReference type="eggNOG" id="ENOG50309K5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713275_0_0_9"/>
    <dbReference type="OMA" id="DAYLVER"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-284-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC77862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="388" mass="43706" checksum="C93639221F632743" modified="2011-10-19" version="1">MSSIIENLQLAAQQVHLINLYQANSEVVYTGYIDRLAPDGVVVNTYDDAGLQDGAVFMRYDVIDEVEMMSEDLDNMAFRLENATTEGLNSVPQPTVALDDQRPVLTQLVTQAQTDHQVVLLVLEDNENYLEGQVQQVTDQTITFKTFDKFNFKNNGQQEIPLAAIQILEFCGNELLLESAFVKTIHTHRATIKVSEFDDVDHTLNNALNEHQLIAIRSADGSDMFFVGFINALNADSVLLNLIDMTGQFGGYTLCRRSLIESVTTQSDYLQTMRGFIELNRQYELNVQPVLNDERLFDATTDLFDSILRQAATFNNLVHITTENPMLPAMTGYPGTLTNGHFIFYNVDDDNQINHVGTMIELDQVVELSFGYMDAYLLEKRLKSTGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU17</accession>
    <name>F9UU17_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system, antitoxin, HigA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">axe</name>
        <name evidence="2" type="ordered locus">lp_0431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003646479.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888451.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_0431"/>
    <dbReference type="EnsemblBacteria" id="CCC77937">
        <property type="protein sequence ID" value="CCC77937"/>
        <property type="gene ID" value="lp_0431"/>
    </dbReference>
    <dbReference type="GeneID" id="66448506"/>
    <dbReference type="KEGG" id="lpl:lp_0431"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.351"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_2_9"/>
    <dbReference type="OMA" id="GNSAKFW"/>
    <dbReference type="PhylomeDB" id="F9UU17"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-358-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC77937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="97" mass="11320" checksum="5755475EB7918A6E" modified="2011-12-14" version="1">MNEIPTPKISEILEEEFMAPLHISAYFLAQQIGVPTSRIQDLLHDRRQVTVDTSLRLGRFFGVSDRYFLELQNDIEIRNLKQIHGAEYAQIKKYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9UU25</accession>
    <name>F9UU25_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbg1</name>
        <name evidence="6" type="ordered locus">lp_0440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
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            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="4">
        <citation type="journal article" date="2013" name="Acta Crystallogr. D" volume="69" first="451" last="463">
            <title>GH1-family 6-P-beta-glucosidases from human microbiome lactic acid bacteria.</title>
            <authorList>
                <person name="Michalska K."/>
                <person name="Tan K."/>
                <person name="Li H."/>
                <person name="Hatzos-Skintges C."/>
                <person name="Bearden J."/>
                <person name="Babnigg G."/>
                <person name="Joachimiak A."/>
            </authorList>
            <dbReference type="PubMed" id="23519420"/>
            <dbReference type="DOI" id="10.1107/S0907444912049608"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
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        <property type="chains" value="A=1-478"/>
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        <property type="entry name" value="Glyco_hydro_1"/>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
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        <location>
            <position position="375"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC77945.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PDB" id="3QOM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="4GZE"/>
        </source>
    </evidence>
    <sequence length="478" mass="54865" checksum="1E901C470D53908D" modified="2011-10-19" version="1">MTIKGRAFPEGFLWGGAVAAHQLEGGYKEGGKGLSTADIMTLGTNERPREITDGVVAGKYYPNHQAIDFYHRYPEDIELFAEMGFKCFRTSIAWTRIFPNGDESEPNEAGLQFYDDLFDECLKNGIQPVVTLAHFEMPYHLVKQYGGWRNRKLIQFYLNFAKVCFERYRDKVTYWMTFNEINNQTNFESDGAMLTDSGIIHQPGENRERWMYQAAHYELVASAAAVQLGHQINPDFQIGCMIAMCPIYPLTAAPADVLFAQRAMQTRFYFADVHCNGTYPQWLRNRFESEHFNLDITAEDLKILQAGTVDYIGFSYYMSFTVKDTGKLAYNEEHDLVKNPYVKASDWGWQVDPVGLRYAMNWFTDRYHLPLFIVENGLGAIDKKTADNQIHDDYRIDYLTDHLRQIKLAVLEDGVDLIGYTPWGCIDLVAASTGQMSKRYGFIYVDENDDGSGSLKRYKKDSFTWFQHVIATNGAEIE</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein, DUF125 family</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ordered locus">lp_3360</name>
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    <organism evidence="6 7">
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
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            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_004567.2"/>
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    </dbReference>
    <dbReference type="STRING" id="220668.lp_3360"/>
    <dbReference type="EnsemblBacteria" id="CCC80349">
        <property type="protein sequence ID" value="CCC80349"/>
        <property type="gene ID" value="lp_3360"/>
    </dbReference>
    <dbReference type="GeneID" id="57026612"/>
    <dbReference type="KEGG" id="lpl:lp_3360"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2802"/>
    <dbReference type="eggNOG" id="COG1814">
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    <dbReference type="HOGENOM" id="CLU_038957_3_1_9"/>
    <dbReference type="OMA" id="NGGWLRP"/>
    <dbReference type="PhylomeDB" id="F9UU47"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PTHR31851"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="225" mass="23872" checksum="D433B26550665E6D" modified="2011-10-19" version="1">MKKRMSLAQRVNILRASVMGANDGILSVAGIVVGVAGATTNSFSILISGLAGMLAGTISMAMGEYVSVNTQKDSQKMAITKQKAALADDYEAEASLVVQKYVNQGISKPLAQQATREMMAEDALTTTVRERYGFNPNQFISPYAAGIASMIAFPTGSILPLVSITFFPPRVKVLATVLAVGIALMITGYVAAMLGNANRRRGMVRNVVAGLLTMIVTYFIGHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD1</accession>
    <name>F9UUD1_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase, MoxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">lp_3461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643555.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890947.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3461"/>
    <dbReference type="EnsemblBacteria" id="CCC80433">
        <property type="protein sequence ID" value="CCC80433"/>
        <property type="gene ID" value="lp_3461"/>
    </dbReference>
    <dbReference type="GeneID" id="57026679"/>
    <dbReference type="KEGG" id="lpl:lp_3461"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2881"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709380_0_0_9"/>
    <dbReference type="OMA" id="YQVVDMD"/>
    <dbReference type="PhylomeDB" id="F9UUD1"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2921-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="397" mass="43946" checksum="5445EB6473C85ADC" modified="2011-10-19" version="1">MALSYQALLTAVPVVLKAGNVPNIVGEAGIGKSALVAEVAKRMGAQLYTTVVSLSEKGDLAIPVPPLTSDSFIQTKRYGQLADVQFGYAHTLIEIIQYAEQHPQQPILWFLDEFNRGTQAVQSELMNLVLQRTINTLKLPEQVQLIIAENPDASMTGFESSTYGVTAGDAAIKDRTVRLVMRADAADWLAWAKQVDERMNRPNIHPLVQQFISEDVTRLNQADVQADLTATPRAWARVSANLYEIEKLPVHQQTAVALDIFQGDVGTELGLVFEQFLEQQAIHLTPAMIYDSQPVGAVVPAPILKQFTAMNEIQKRTVLASCLALTTTYPLTDDQHAGRFMQLLQTLSQDGQFALVQQIGHERDLLKQLYTANVAKQSPYVTALYQYLQQVASWSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUD7</accession>
    <name>F9UUD7_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription regulator. LacI family, lactose related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lacR</name>
        <name evidence="5" type="ordered locus">lp_3470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102175.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890953.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3470"/>
    <dbReference type="EnsemblBacteria" id="CCC80439">
        <property type="protein sequence ID" value="CCC80439"/>
        <property type="gene ID" value="lp_3470"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3470"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2887"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_1_0_9"/>
    <dbReference type="OMA" id="NPAPELF"/>
    <dbReference type="PhylomeDB" id="F9UUD7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2927-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC80439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="336" mass="37695" checksum="8DE5C36A11C2A419" modified="2011-10-19" version="1">MPTIREIAAKAGYSPATVSRLLNNDPSFSISDHARKKILQTAQNLNYEQPNTTHGLAYQIATIFAVQPKQELEDIYFSNLRQSLVEHGKQANLKLTFYPDIDHIPHDIDGVMAVGEFDSDALHKLRQLTPHRIFVDSNPDPHHFNSVQPNLQAITEQAIDQLIAAGDTPIGLINGGYWNKDQQVTHQQDPRQKYFESRLRELQLFDSRFLFIGGEFSVASGYRLGQQVVQSLSKQALPKGFLVGSDPLAVGVLQAFNENKITVPTDTAIISINDIDIARYVSPPLTTFHIDTDDLAAQAITTLKDTIIFDRSQKRMVLVDTKLIYRKSFVKPTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUH6</accession>
    <name>F9UUH6_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">lp_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011102195.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890992.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3510"/>
    <dbReference type="EnsemblBacteria" id="CCC80478">
        <property type="protein sequence ID" value="CCC80478"/>
        <property type="gene ID" value="lp_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_3510"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2926"/>
    <dbReference type="eggNOG" id="COG3589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065324_1_0_9"/>
    <dbReference type="OMA" id="YQANTPF"/>
    <dbReference type="PhylomeDB" id="F9UUH6"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2966-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC80478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="362" mass="41075" checksum="2B2352E64BE21788" modified="2011-10-19" version="1">MTMRQLGLSIYPDHSDFEENAAYLKLGQHYGFTRIFMSMLEISGTVAETKAKYQKIIDVGNQLGYQTILDVSPRIFKQLGISYKDLKFFADLHVTGIRLDEGFDGATEALLSYNPYGLIIELNMSNDVDYLNNILSYQANVPFIYGCHNFYPQVGTALPYNFFVKCSERFRKFGIHSAAFVASQVGTMGPWNVNDGLPTLEADRRLPIAVQAKHLFASGLIDDVIIGNAYASEAELAALSAINRYQVQFHIEFEAQTNAIERTIALTPQHFRRGDINPNVIRSTMPRVTYKETPNSPHDNDVEFQRGDVLVGNDNFGIYKNELQVVLQPHCEPRKNRIGRIAPEELLLLDFIKPWSKFRFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9UUK8</accession>
    <name>F9UUK8_LACPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system, galactitol-specific EIIC component</fullName>
            <ecNumber evidence="11">2.7.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts35C</name>
        <name evidence="11" type="ordered locus">lp_3546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-06" db="EMBL/GenBank/DDBJ databases">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>WCFS1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.69" evidence="11"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642908.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004891024.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="STRING" id="220668.lp_3546"/>
    <dbReference type="EnsemblBacteria" id="CCC80510">
        <property type="protein sequence ID" value="CCC80510"/>
        <property type="gene ID" value="lp_3546"/>
    </dbReference>
    <dbReference type="GeneID" id="57026746"/>
    <dbReference type="KEGG" id="lpl:lp_3546"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2957"/>
    <dbReference type="eggNOG" id="COG3775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040393_0_0_9"/>
    <dbReference type="OMA" id="VFDMGWP"/>
    <dbReference type="PhylomeDB" id="F9UUK8"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2998-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103111">
        <property type="term" value="F:D-glucosamine PTS permease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015577">
        <property type="term" value="F:galactitol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013853">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37324">
        <property type="entry name" value="PTHR37324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006304">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="10">
        <location>
            <begin position="8"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCC80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000432"/>
        </source>
    </evidence>
    <sequence length="423" mass="45190" checksum="D74C2467A93507AE" modified="2011-10-19" version="1">MKVLSDVVQSIINVGPSVMLPIIIFIVGLIFRVKPGKALTSGITVGIGMIGINLVINLLTTSVGPAAQAMVKRFGFHLTIIDAGWPAVSAGTWAQPISAIMIPIILVVNVGLILLNLTKTLDIDIWNYWHMIAAAATAYVVTKNWWFAILCGIIYEIAVLIIADKTAPKVAEFYGLDGISFPTGSAAAYGLLGIPIGWVVSKIPGIRKWDVDPQTIQKRFGVFGEPMVMGIVIGMLLAALGGYSVPNILKLGMSMGGVMFLMPRMVKILMEGLIPIQEGAQKLLQEKYGNRKIYLGMDAALSTGSPATLATGLLMVPITLFLAIILPGNRVLPFGDLATIPFFAALIVPSRKGNIVHSVLSATIVMVFALLMATDFGPTLTSMMHGIVAFPKGASEVTNLDTGGNILNWLILKLSQLVQPLFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>P59603</accession>
    <accession>F9ULZ9</accession>
    <name>ASSY_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate synthase</fullName>
            <ecNumber evidence="1">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argG</name>
        <name type="ordered locus">lp_0775</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641033.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888752.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P59603"/>
    <dbReference type="SMR" id="P59603"/>
    <dbReference type="STRING" id="220668.lp_0775"/>
    <dbReference type="EnsemblBacteria" id="CCC78238">
        <property type="protein sequence ID" value="CCC78238"/>
        <property type="gene ID" value="lp_0775"/>
    </dbReference>
    <dbReference type="GeneID" id="57024479"/>
    <dbReference type="KEGG" id="lpl:lp_0775"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.655"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_9"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="PhylomeDB" id="P59603"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-673-MON"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148602" description="Argininosuccinate synthase">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <sequence length="411" mass="45154" checksum="4198183D3BFF93E5" modified="2003-04-23" version="1">MVKQNDKIILAYSGGLDTSVAISWLKDKGYDVVACGIDVGEGKDMDAIKEKALKLGAVSSYMIDAKQEFAEEYALIALQGHTLYEGEYPLVSALSRPLIAKKLVTLAKQEHAVAIAHGCTGKGNDQVRFEVAIHALAPDIKIEAPVRDWHWSREEEIDYAKEHNIPVPINLDSPYSIDENLWGRANECGILEDPWQGAPADAFDRTKALADTPDTPTTLEITFEAGVPVALDGESLNLADLIIKLDQIAGEHGIGRIDHIENRLVGIKSREVYEAPAATVLLKAHKDLEDLTFERELAHFKPIIEQKLADTIYNGLWFSPLMEAMVAFLKQTQQVVNGVVRVQLFKGNVITEGRKSPNSLYDTNLATYTSADSFDQQAAVGFIKLWGLPTQVNAQVQAKAQAEAKTDKAHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>P77888</accession>
    <accession>F9URI0</accession>
    <name>PYRF_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">OMP decarboxylase</fullName>
            <shortName evidence="1">OMPDCase</shortName>
            <shortName evidence="1">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrF</name>
        <name type="ordered locus">lp_2698</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="182" first="37" last="43">
            <title>Structure and organisation of the pyrimidine biosynthesis pathway genes in Lactobacillus plantarum: a PCR strategy for sequencing without cloning.</title>
            <authorList>
                <person name="Elagoez A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Kammerer B."/>
            </authorList>
            <dbReference type="PubMed" id="8982065"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00461-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2003-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kammerer B."/>
                <person name="Elagoz A."/>
                <person name="Abdi A."/>
                <person name="Hubert J.-C."/>
                <person name="Bringel F."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="Z54240">
        <property type="protein sequence ID" value="CAA91007.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642610.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004890333.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P77888"/>
    <dbReference type="SMR" id="P77888"/>
    <dbReference type="STRING" id="220668.lp_2698"/>
    <dbReference type="EnsemblBacteria" id="CCC79819">
        <property type="protein sequence ID" value="CCC79819"/>
        <property type="gene ID" value="lp_2698"/>
    </dbReference>
    <dbReference type="GeneID" id="57026079"/>
    <dbReference type="KEGG" id="lpl:lp_2698"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.2258"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_1_1_9"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="PhylomeDB" id="P77888"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-2310-MON"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000134551" description="Orotidine 5'-phosphate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <sequence length="237" mass="24949" checksum="FB3A5D24FD4D47E7" modified="2003-03-25" version="2">MKRPIIIALDFPTAERALAFLDQFPADLHVTVKIGMELFYAAGPSIVTDVQARGHAVFLDLKLHDIPNTVESAMRVIGRLGVTYTTVHAAGGHVMLSAAKRGLVAGAMAAGVTAPKLLAITQLTSTNQAILNQDQQIMGTVRASVVHYAKLARASDCDGVICSAQEVQAIHTAVGADFLGITPGIRPASAQSDDQQRVMTPAAAAKAGSNGLVIGRPITQAAEPVQAYRDIMTEWSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q88V19</accession>
    <accession>F9UQI7</accession>
    <name>MURI_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate racemase</fullName>
            <ecNumber evidence="1">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murI</name>
        <name type="ordered locus">lp_2268</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003644631.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889990.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88V19"/>
    <dbReference type="SMR" id="Q88V19"/>
    <dbReference type="STRING" id="220668.lp_2268"/>
    <dbReference type="EnsemblBacteria" id="CCC79476">
        <property type="protein sequence ID" value="CCC79476"/>
        <property type="gene ID" value="lp_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="lpl:lp_2268"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1919"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_9"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="PhylomeDB" id="Q88V19"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1961-MON"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
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        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000095481" description="Glutamate racemase">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <sequence length="273" mass="29713" checksum="201F79C1A2570763" modified="2003-06-01" version="1">MANEHAIGFMDSGVGGLTVVKQALKQLPRETVYFIGDQARLPYGPRPAEQVRTFSFQMADFLMAKQIKMLVIACNTATAAALPALRQQLSIPVIGVIAPGSRAALKASHRNRIGVIATEGTIRSNAYRDAILTKDPTATVVSQACPKFVPLVESNEYQSTVAKRVVAETLKQLKKQDVDTLVLGCTHYPLLRPLIQNVMGPGVTLIDSGAETVNDVSAVLDYLDIANDRSTKRYPDEYYTTGAADQFEAIARNWLGQPDFHAQHIDLGSEAND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q88VB7</accession>
    <accession>F9UQ88</accession>
    <name>Y2149_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0223 protein lp_2149</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">lp_2149</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0223 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC79377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011101669.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889891.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88VB7"/>
    <dbReference type="SMR" id="Q88VB7"/>
    <dbReference type="STRING" id="220668.lp_2149"/>
    <dbReference type="EnsemblBacteria" id="CCC79377">
        <property type="protein sequence ID" value="CCC79377"/>
        <property type="gene ID" value="lp_2149"/>
    </dbReference>
    <dbReference type="GeneID" id="57025683"/>
    <dbReference type="KEGG" id="lpl:lp_2149"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1818"/>
    <dbReference type="eggNOG" id="COG4476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166693_1_0_9"/>
    <dbReference type="OMA" id="SYDWSTQ"/>
    <dbReference type="PhylomeDB" id="Q88VB7"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1838-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01041">
        <property type="entry name" value="UPF0223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023324">
        <property type="entry name" value="BH2638-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007920">
        <property type="entry name" value="UPF0223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05256">
        <property type="entry name" value="UPF0223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037260">
        <property type="entry name" value="UPF0223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158504">
        <property type="entry name" value="SSF158504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000216678" description="UPF0223 protein lp_2149">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01041"/>
        </source>
    </evidence>
    <sequence length="97" mass="11323" checksum="8E8DEAEB884B5002" modified="2003-06-01" version="1">MKMPKHNDNYQYPLDETWTTAEIIKVTTFYQAIEAANEGTIATADLLAAYRDFKTVVPAKSEEKRLARDYEAASGYRIYQTMRAAQETNKQRFQYRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q88WS9</accession>
    <accession>F9UNS1</accession>
    <name>RL32_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">lp_1535.1</name>
        <name type="ORF">lp_1535A</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003638547.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004889374.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88WS9"/>
    <dbReference type="SMR" id="Q88WS9"/>
    <dbReference type="STRING" id="220668.lp_1535a"/>
    <dbReference type="EnsemblBacteria" id="CCC78860">
        <property type="protein sequence ID" value="CCC78860"/>
        <property type="gene ID" value="lp_1535a"/>
    </dbReference>
    <dbReference type="GeneID" id="49393812"/>
    <dbReference type="GeneID" id="57025131"/>
    <dbReference type="GeneID" id="66449427"/>
    <dbReference type="KEGG" id="lpl:lp_1535a"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.1294"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_9"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="PhylomeDB" id="Q88WS9"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-1321-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000172353" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6635" checksum="9A821B179AEF7E38" modified="2003-06-01" version="1">MAVPARRTSKMRKRNRRGHIKLATPNLAPCPNCGELRVSHRVCPSCGYYNGKQVVKVNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q88XZ2</accession>
    <accession>F9UMJ9</accession>
    <name>RPOC_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">lp_1022</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641247.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888952.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88XZ2"/>
    <dbReference type="SMR" id="Q88XZ2"/>
    <dbReference type="STRING" id="220668.lp_1022"/>
    <dbReference type="PRIDE" id="Q88XZ2"/>
    <dbReference type="EnsemblBacteria" id="CCC78438">
        <property type="protein sequence ID" value="CCC78438"/>
        <property type="gene ID" value="lp_1022"/>
    </dbReference>
    <dbReference type="GeneID" id="57024685"/>
    <dbReference type="GeneID" id="66448939"/>
    <dbReference type="KEGG" id="lpl:lp_1022"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.864"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_9"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="PhylomeDB" id="Q88XZ2"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-881-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000067749" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="892"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135318" checksum="704B67A30398CACC" modified="2003-06-01" version="1">MIDVNKFESMQIGLASPDKIRSWSYGEVKKPETINYRTLKPEKDGLFDERIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRSKVRRERMGHIELAAPVTHIWYFKGIPSRMGLVLDMSPRALEEIIYFASYVVIESGNTPLEKKQLLSEREYREKKAQYGNEFEAAMGAEAIKRLLNNVDLEKEARDLKETLKDASGQKRTRAVRRLDIIEAFVTSGNEPAWMVMDAIPVIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPGIIVQNEKRMLQEAVDALIDNGRRGRPVAGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVGPFLKMNQMGLPRQMALELFKPFIMKELVKRELASNIKNAKRKIEHADDDVWGVLEDVIKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLACEAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAHHILAPKDGKPVVTPSQDMVIGNYYLTTEEIGREGEGMIFKDLNEAQKAYQSGYVHLHSRVGIQVSSMPDKPFTDDQKQAVLVTTVGKAIFNNILPGKFPYLNEPTNDNLIAGTPDKYFLKPGEDIHQFLDAQEIIPPFKKGFLADIIAEVYKQYHVTATSLLLDRMKDLGYNISTKSGLTVGVADITGLKEKPAIIAEAHKQVNTISKQFRRGLITDDERYERVIGVWNDAKDQIQQKLIESFNADNPIFMMSDSGARGNISNFTQLAGMRGLMAAPNGKIMELPILSNFREGLSVLEMFISTHGARKGMTDTALKTANSGYLTRRLVDVAQDVIVREKDCGTDRGLRIHAIMEGNEVIEPLYDRILGRYTMKTVFDPETHDEIVGNNVLIDEDLAHKIVDAGVTEVTIRSAFTCNTKHGVCEHCYGRNMATGDEVEVGEAVGTVAAQSIGEPGTQLTMRNFHTGGVAGDDITQGLPRVQEIVESRNPKGRAEISEVTGTVELIEENPAERTKEVTVKGETDTRTYTLPLTARMAVSEGDFIHRGAALNIGSIDPKQLIQVRDVLSTENYLLREVQKVYRMQGVEIGDKHVEIMIRQMLRKVRVMDPGDTDVLPGTLMDIADFKDENYKTLIAGGIPATSRPVILGITKAALETNSFLSAASFQETTRVLTDAAIRGKNDPLIGLKENVIIGKIIPAGTGMPVYRHIKPKEVGNVADGVYSISDLEKQMQEQDASK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z86</accession>
    <accession>F9UKV3</accession>
    <name>GLMU_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">lp_0467</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003642031.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888482.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z86"/>
    <dbReference type="SMR" id="Q88Z86"/>
    <dbReference type="STRING" id="220668.lp_0467"/>
    <dbReference type="PRIDE" id="Q88Z86"/>
    <dbReference type="EnsemblBacteria" id="CCC77968">
        <property type="protein sequence ID" value="CCC77968"/>
        <property type="gene ID" value="lp_0467"/>
    </dbReference>
    <dbReference type="GeneID" id="57024266"/>
    <dbReference type="KEGG" id="lpl:lp_0467"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.385"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_9"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="PhylomeDB" id="Q88Z86"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-389-MON"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000233787" description="Bifunctional protein GlmU">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="252"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="351"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="366"/>
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            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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            <position position="377"/>
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            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <sequence length="460" mass="50080" checksum="DB764EE9FB7975CD" modified="2003-06-01" version="1">MTTKNAIIMAAGKGTRMKSKLVKVLHQVCGKSMVDHVLTQVEATHMANIVTIVGHGAKDVEAALGDRTEYAVQTEQLGTGHAVLQAESLLKDADGMTLIVSGDTPLFKAETFEELFEYHQAKGAAGTILTSKAPNPQGYGRVVRNRLGIVEKIVEQKDATKEEQEIHEINTGVYCFDNQKLFAALHEVTNDNAQGEYYLTDVIQIMKNQGDVVAAYQMDDFDESMGVNTRAALAQATKVMQQRINAQHMENGVSIINPDDTYIDAGVKIGADTIIEPGVLIKGHTTIGEDCFIGAHSEIHDMVIEDRVRVTASFLEDSIMHADSNIGPYSHLRPQAEIGEHVHLGNFVEVKKAKIGNRTKVGHLTYVGDATLGQDINVGCGVVFVNYDGVNKHHTNVGDSAFIGSNSNIIAPVEVADHSFIAAGSTITDDVNFHDMAIARARQTNKPDFWGRLPHEPENM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q88Z97</accession>
    <accession>F9UU37</accession>
    <name>SYM_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="synonym">metS</name>
        <name type="ordered locus">lp_0454</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003643823.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888471.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q88Z97"/>
    <dbReference type="SMR" id="Q88Z97"/>
    <dbReference type="STRING" id="220668.lp_0454"/>
    <dbReference type="PRIDE" id="Q88Z97"/>
    <dbReference type="EnsemblBacteria" id="CCC77957">
        <property type="protein sequence ID" value="CCC77957"/>
        <property type="gene ID" value="lp_0454"/>
    </dbReference>
    <dbReference type="GeneID" id="57024252"/>
    <dbReference type="KEGG" id="lpl:lp_0454"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.374"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_9"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="PhylomeDB" id="Q88Z97"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-378-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000139224" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="581"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <sequence length="683" mass="76797" checksum="2E68E67D28DA8560" modified="2003-06-01" version="1">MAETKPTYYITTPIYYPSGKLHIGNSYTTIACDTLARYKRAMGYDVYFLTGTDEHGLKIEEKAEKLNTDPKSYVDGMAKQIKDLWQLLEISNDKFIRTTDDYHERAVQEIFDRLLKNGDIYLGEYEGWYSVDDEEYFTETQLAEVFRDDNGKVIGGKAPSGHEVELVKEQSYFFKMSKYADWLLDYYQSHPDFIEPANRMTEMINNFIKPGLEDLAVSRTSFTWGVPVKSDPKHVVYVWIDALTNYITALGYATGDSEDLFNKFWPADVQMVGKEIVRFHTIYWPIILHALGLPLPKKVFGHGWLLMKDGKMSKSKGNVIYPETLVERYGLDALRYYLVKAMPYGNDGLFTPEDFVARVNYDLANDLGNLLNRTIAMINKYEDGQLPAFKAGVTEFDADLEATAATTIKNFNACMDSLHLSDALAEVWKLVSRTNKYIDETAPWQLAKSDDANDADKLASVMAHLAASLRVIASLISPVMTHAPKEIFTQLGLDPATLAIADLQLADLPAGAQVVAKGTPIFPRVDMDAEVEFLKGKMTKSDKQKGRKAMENAKHEAEVEQGWNPAETNLNLTKPAITIDDFDKVELKVAEVITVQKLKGADKLLQFRLDAGDADHRQILSGIAKWYPEPEELIGKKVIIVGNLKPRKLRGEMSQGMLLSAEHDGQVQLITVPDNMVNGSLIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q890K0</accession>
    <accession>F9US41</accession>
    <name>RS18_LACPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">lp_0011</name>
    </gene>
    <organism>
        <name type="scientific">Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)</name>
        <name type="synonym">Lactobacillus plantarum</name>
        <dbReference type="NCBI Taxonomy" id="220668"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Lactobacillales</taxon>
            <taxon>Lactobacillaceae</taxon>
            <taxon>Lactiplantibacillus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1990" last="1995">
            <title>Complete genome sequence of Lactobacillus plantarum WCFS1.</title>
            <authorList>
                <person name="Kleerebezem M."/>
                <person name="Boekhorst J."/>
                <person name="van Kranenburg R."/>
                <person name="Molenaar D."/>
                <person name="Kuipers O.P."/>
                <person name="Leer R."/>
                <person name="Tarchini R."/>
                <person name="Peters S.A."/>
                <person name="Sandbrink H.M."/>
                <person name="Fiers M.W.E.J."/>
                <person name="Stiekema W."/>
                <person name="Klein Lankhorst R.M."/>
                <person name="Bron P.A."/>
                <person name="Hoffer S.M."/>
                <person name="Nierop Groot M.N."/>
                <person name="Kerkhoven R."/>
                <person name="De Vries M."/>
                <person name="Ursing B."/>
                <person name="De Vos W.M."/>
                <person name="Siezen R.J."/>
            </authorList>
            <dbReference type="PubMed" id="12566566"/>
            <dbReference type="DOI" id="10.1073/pnas.0337704100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="J. Bacteriol." volume="194" first="195" last="196">
            <title>Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome.</title>
            <authorList>
                <person name="Siezen R.J."/>
                <person name="Francke C."/>
                <person name="Renckens B."/>
                <person name="Boekhorst J."/>
                <person name="Wels M."/>
                <person name="Kleerebezem M."/>
                <person name="van Hijum S.A.F.T."/>
            </authorList>
            <dbReference type="PubMed" id="22156394"/>
            <dbReference type="DOI" id="10.1128/JB.06275-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>ATCC BAA-793 / NCIMB 8826 / WCFS1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL935263">
        <property type="protein sequence ID" value="CCC77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003641635.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004888102.1">
        <property type="nucleotide sequence ID" value="NC_004567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q890K0"/>
    <dbReference type="SMR" id="Q890K0"/>
    <dbReference type="STRING" id="220668.lp_0011"/>
    <dbReference type="EnsemblBacteria" id="CCC77588">
        <property type="protein sequence ID" value="CCC77588"/>
        <property type="gene ID" value="lp_0011"/>
    </dbReference>
    <dbReference type="GeneID" id="57026872"/>
    <dbReference type="GeneID" id="66448166"/>
    <dbReference type="KEGG" id="lpl:lp_0011"/>
    <dbReference type="PATRIC" id="fig|220668.9.peg.9"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_9"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="PhylomeDB" id="Q890K0"/>
    <dbReference type="BioCyc" id="LPLA220668:G1GW0-9-MON"/>
    <dbReference type="Proteomes" id="UP000000432">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111167" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="78" mass="9103" checksum="4604F8A45CA2262C" modified="2003-06-01" version="1">MAQQRRGGRRRRKVDFIAANHIEYIDYKDTDLLRRFISERGKILPRRVTGTSAKNQRSLTIAIKRARIMGLLAFVSED</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>